Detailed information for compound 799899

Basic information

Technical information
  • TDR Targets ID: 799899
  • Name: BAS 14393799
  • MW: 343.417 | Formula: C20H25NO4
  • H donors: 1 H acceptors: 2 LogP: 2.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1C1CC(=O)NC(=C1C(=O)OC1CCCC1)C
  • InChi: 1S/C20H25NO4/c1-3-24-17-11-7-6-10-15(17)16-12-18(22)21-13(2)19(16)20(23)25-14-8-4-5-9-14/h6-7,10-11,14,16H,3-5,8-9,12H2,1-2H3,(H,21,22)
  • InChiKey: KGPQLJYGTBTVMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • IVK/2009905

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0018 0.0026
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0044 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0612 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0693 0.112
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0163 0.3623 0.5513
Schistosoma mansoni hypothetical protein 0.0015 0.0069 0.008
Echinococcus granulosus solute carrier family 22 0.0014 0.0044 0.0066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0306
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0245 0.3831
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0446 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0158 0.0701
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0044 0.0026
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0245 0.0346
Brugia malayi CHD4 protein 0.0013 0.0017 0.0032
Brugia malayi Heterochromatin protein 1 0.0068 0.1344 0.264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2129 0.5032
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0446 0.0429
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0044 0.0087
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0245 0.0481
Plasmodium falciparum mitogen-activated protein kinase 2 0.0163 0.3623 0.3612
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0245 0.1894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 1 1
Trypanosoma brucei glucose transporter 2A 0.0031 0.0455 0.7373
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0431 0.0987
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0455 0.7373
Plasmodium falciparum hexose transporter 0.0101 0.2129 0.2115
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0158 0.0214
Onchocerca volvulus 0.0151 0.3334 0.5682
Trypanosoma brucei glucose transporter, putative 0.0031 0.0455 0.7373
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0155 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0245 0.3815
Echinococcus granulosus dna polymerase eta 0.0019 0.0158 0.0336
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0155 1
Loa Loa (eye worm) MBCTL1 0.0053 0.098 0.1923
Entamoeba histolytica protein kinase, putative 0.0031 0.0446 1
Echinococcus granulosus chromobox protein 1 0.0068 0.1344 0.3161
Toxoplasma gondii sugar transporter ST2 0.0014 0.0044 0.004
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0245 0.0227
Schistosoma mansoni hypothetical protein 0.0015 0.0063 0.007
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0877 0.2049
Brugia malayi mbt repeat family protein 0.0047 0.0825 0.1621
Echinococcus multilocularis dna polymerase eta 0.0019 0.0158 0.0336
Onchocerca volvulus 0.0255 0.5834 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0431 0.0843
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0044 0.0042
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0044 0.0083
Giardia lamblia Sugar-proton symporter 0.0014 0.0044 0.0634
Schistosoma mansoni hypothetical protein 0.0033 0.0494 0.0724
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0004
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0044 0.0219
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0069 0.0126
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0431 0.1453
Echinococcus granulosus solute carrier family 22 0.0014 0.0044 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0354 0.0578
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0446 0.0876
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0446 0.1023
Schistosoma mansoni protein kinase 0.0031 0.0446 0.0651
Schistosoma mansoni ap endonuclease 0.0019 0.0155 0.021
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0044 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0548 0.1266
Schistosoma mansoni glucose transport protein 0.0101 0.2129 0.3202
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0245 0.0543
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0155 0.0235
Giardia lamblia Hexose transporter 0.0014 0.0044 0.0634
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0446 0.1023
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0446 0.0429
Loa Loa (eye worm) hypothetical protein 0.0049 0.0877 0.172
Brugia malayi mbt repeat family protein 0.0047 0.0825 0.1621
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0446 0.0429
Loa Loa (eye worm) sugar transporter 0.0014 0.0044 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Loa Loa (eye worm) sugar transporter 0.0101 0.2129 0.4181
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0431 0.0847
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.086 0.169
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.086 0.1687
Brugia malayi Thioredoxin reductase 0.0038 0.0612 0.1202
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0455 0.0752
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0431 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0825 0.1225
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1215 0.2853
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0623 0.104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0044 0.0045
Trypanosoma brucei glucose transporter, putative 0.0031 0.0455 0.7373
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0447 0.1026
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0026
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0431 0.9483
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0044 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.2369
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0044 0.0132
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0612 0.2985
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0825 0.1925
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0069 0.0132
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0245 0.1894
Leishmania major protein kinase, putative 0.0031 0.0446 0.3576
Plasmodium falciparum thioredoxin reductase 0.0038 0.0612 0.0595
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0155 0.3316
Schistosoma mansoni sugar transporter 0.0014 0.0044 0.0042
Trypanosoma brucei ISWI complex protein 0.0015 0.0063 0.078
Trypanosoma brucei sugar transporter, putative 0.0014 0.0044 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0548 0.1266
Schistosoma mansoni chromobox protein 0.0068 0.1344 0.2012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0155 0.2325
Brugia malayi Bromodomain containing protein 0.0073 0.1467 0.2883
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0446 0.1023
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0455 0.3656
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0158 0.0336
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1344 0.228
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0446 0.0655
Brugia malayi Pre-SET motif family protein 0.0032 0.0476 0.0935
Echinococcus granulosus solute carrier family 22 0.0014 0.0044 0.0066
Trypanosoma brucei glucose transporter, putative 0.0031 0.0455 0.7373
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.4215 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2129 0.5032
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0455 0.0752
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0158 0.009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0446 0.0873
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0155 0.2305
Leishmania major glucose transporter, lmgt1 0.0031 0.0455 0.3656
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0825 0.1925
Trichomonas vaginalis set domain proteins, putative 0.0255 0.5834 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.2369
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2129 0.363
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.1107 0.2598
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Onchocerca volvulus 0.003 0.0424 0.0656
Schistosoma mansoni sugar transporter 0.0014 0.0044 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2129 0.5032
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0044 0.0219
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0455 0.7366
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0044 0.0066
Schistosoma mansoni glucose transporter 0.0014 0.0044 0.0042
Plasmodium vivax SET domain protein, putative 0.0032 0.0476 0.0458
Brugia malayi major facilitator superfamily protein 0.0014 0.0044 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0455 0.7366
Brugia malayi glutathione reductase 0.0038 0.0612 0.1202
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0158 0.0336
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0446 0.0873
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0044 0.0441
Loa Loa (eye worm) hypothetical protein 0.0038 0.0623 0.122
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0069 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0044 0.0045
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.098 0.2295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.2349
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0455 0.0752
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0044 0.0066
Echinococcus multilocularis GPCR, family 2 0.0015 0.0069 0.0126
Schistosoma mansoni zinc finger protein 0.0019 0.0163 0.0223
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0018 0.0035
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0877 0.2049
Schistosoma mansoni hypothetical protein 0.0015 0.0069 0.008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0069 0.0136
Toxoplasma gondii protein kinase, putative 0.0285 0.6558 1
Leishmania major glucose transporter, lmgt2 0.0031 0.0455 0.3656
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0476 0.07
Brugia malayi major facilitator superfamily protein 0.0014 0.0044 0.0087
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0245 0.0346
Echinococcus multilocularis General substrate transporter 0.0087 0.1788 0.4219
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Brugia malayi Sugar transporter family protein 0.0014 0.0044 0.0087
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.098 0.2295
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0044 0.0441
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0431 0.0987
Trypanosoma cruzi ISWI complex protein 0.0015 0.0063 0.0756
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0044 0.0083
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0158 0.2369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0476 0.0696
Schistosoma mansoni hypothetical protein 0.0015 0.0069 0.008
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2129 0.5032
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0158 0.2349
Schistosoma mansoni sugar transporter 0.0014 0.0044 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0446 0.0651
Echinococcus granulosus General substrate transporter 0.0087 0.1788 0.4219
Echinococcus multilocularis chromobox protein 1 0.0068 0.1344 0.3161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0877 0.1304
Plasmodium falciparum protein kinase 7 0.0285 0.6558 0.6551
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0069 0.0126
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0446 0.1023
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.098 0.2295
Echinococcus multilocularis solute carrier family 22 0.0014 0.0044 0.0066
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0178 0.0275
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0552 0.8983
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2129 0.5032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0155 0.2305
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0044 0.0087
Loa Loa (eye worm) hypothetical protein 0.0047 0.0825 0.1618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0446 0.1023
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0431 0.0628
Entamoeba histolytica protein kinase, putative 0.0031 0.0446 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0044 0.0066
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.2008 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0552 0.0816
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1215 0.183
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.2008 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0119 0.0229
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0612 0.0595
Brugia malayi chromobox protein homolog 3 0.0038 0.0623 0.1224
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Echinococcus granulosus solute carrier family 22 0.0014 0.0044 0.0066
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0155 0.033
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0104 0.0209
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0624 0.1447
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0158 0.024
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0612 0.1199
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0044 0.0219
Echinococcus granulosus dna polymerase kappa 0.0019 0.0158 0.0336
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.2008 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0431 0.0628
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0163 0.0729
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0245 1
Echinococcus multilocularis zinc finger protein 0.0019 0.0163 0.035
Brugia malayi Cam kinase protein 1 0.0031 0.0446 0.0876
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0446 0.0429
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1776 0.8837
Loa Loa (eye worm) glutathione reductase 0.0038 0.0612 0.1199
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0245 0.0346
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0104 0.0133
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.1107 0.2598
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0446 0.0655
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1215 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0623 0.0999
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0877 0.1304
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0354 0.0578
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0552 0.8983
Schistosoma mansoni protein kinase 0.0031 0.0446 0.0651
Trypanosoma brucei unspecified product 0.0019 0.0158 0.2369
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0446 0.1023
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0446 0.0429
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0069 0.0136
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0446 0.7213
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1344 0.2638
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0623 0.104
Schistosoma mansoni ap endonuclease 0.0019 0.0155 0.021
Schistosoma mansoni chromobox protein 0.0068 0.1344 0.2012
Trypanosoma brucei glucose transporter, putative 0.0031 0.0455 0.7373
Plasmodium vivax hexose transporter 0.0101 0.2129 0.2115
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0044 0.0219
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1776 0.8837
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0158 0.1166
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0455 0.7366
Leishmania major DNA polymerase eta, putative 0.0019 0.0158 0.1166
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0155 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0044 0.0045
Echinococcus granulosus chromobox protein 1 0.0068 0.1344 0.3161
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0455 0.0752
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0245 0.5487
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0188 0.0367
Schistosoma mansoni hypothetical protein 0.002 0.0188 0.026
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1344 0.228
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0158 0.024
Trypanosoma brucei glucose transporter, putative 0.0031 0.0455 0.7373
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0017 0.0029
Brugia malayi Bromodomain containing protein 0.0037 0.0604 0.1186
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0233 0.0329
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0552 0.4459
Plasmodium vivax glutathione reductase, putative 0.0038 0.0612 0.0595
Plasmodium vivax sugar transporter, putative 0.0014 0.0044 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0158 0.0309
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.003 0.0431 0.0843
Loa Loa (eye worm) hypothetical protein 0.0042 0.0706 0.1384
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0245 0.0443
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0155 0.0235
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.2349
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0552 0.8986
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0552 0.0534
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0624 0.1447
Mycobacterium ulcerans sugar transporter 0.0014 0.0044 0.0219
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0693 0.116
Brugia malayi hypothetical protein 0.0014 0.0044 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Brugia malayi hypothetical protein 0.0014 0.0044 0.0087
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0825 0.1225
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0455 0.0752
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0446 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0455 0.0752
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0476 0.1093
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.04 0.0913
Leishmania major glucose transporter, lmgt3 0.0031 0.0455 0.3656
Brugia malayi Sugar transporter family protein 0.0014 0.0044 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Onchocerca volvulus 0.0043 0.0744 0.1209
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0155 0.1144
Schistosoma mansoni glucose transport protein 0.0101 0.2129 0.3202
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.086 0.1687
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.098 0.1926
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0455 0.7373
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0477
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1776 0.8837
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0446 0.0873
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0233 0.0516
Schistosoma mansoni protein kinase 0.0031 0.0446 0.0651
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0104 0.0209
Schistosoma mansoni DNA polymerase eta 0.0019 0.0158 0.0214
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1215 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0158 0.0306
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.2369
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0044 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0744 0.1103
Brugia malayi hypothetical protein 0.0014 0.0044 0.0087
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0446 0.0429
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0431 0.071
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.2008 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0446 0.0429
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.2349
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0155 0.0137
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.4215 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2129 0.5032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1215 0.2853
Mycobacterium tuberculosis Probable reductase 0.0086 0.1776 0.8837
Echinococcus granulosus zinc finger protein 0.0019 0.0163 0.035
Trypanosoma cruzi ISWI complex protein 0.0015 0.0063 0.0756
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0158 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0104 0.0133
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.1776 0.8746
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0044 0.0441
Echinococcus multilocularis chromobox protein 1 0.0068 0.1344 0.3161
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1776 0.8837
Schistosoma mansoni hypothetical protein 0.0288 0.6614 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.5089 1
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0114 0.1622
Trypanosoma cruzi hexose transporter 0.0031 0.0455 0.7366
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0455 0.7373
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0163 0.3623 0.3612
Loa Loa (eye worm) hypothetical protein 0.004 0.0661 0.1296
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1215 1
Schistosoma mansoni zinc finger protein 0.0015 0.0063 0.007
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0245 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0155 0.0301
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.04 0.0913
Toxoplasma gondii sugar transporter ST3 0.0014 0.0044 0.004
Brugia malayi Sugar transporter family protein 0.0101 0.2129 0.4183
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0552 0.4459
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Trypanosoma brucei glucose transporter, putative 0.0031 0.0455 0.7373
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0163 0.0729
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0158 0.0309
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0446 0.0429
Brugia malayi PHD-finger family protein 0.0024 0.0289 0.0568
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1215 0.1816
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0552 0.0534
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0044 0.0045
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0494 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0044 0.0045
Brugia malayi hypothetical protein 0.0151 0.3334 0.655
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0446 0.1023
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Toxoplasma gondii sugar transporter ST1 0.0014 0.0044 0.004
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0233 0.0516
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0825 0.1925
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0044 0.0132
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1215 0.1816
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0044 0.1913
Toxoplasma gondii exonuclease III APE 0.0019 0.0155 0.0209
Leishmania major hypothetical protein, conserved 0.0014 0.0044 0.0219
Loa Loa (eye worm) hypothetical protein 0.0151 0.3334 0.6549
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.098 0.2295
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1215 1
Plasmodium falciparum glutathione reductase 0.0038 0.0612 0.0595
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0575
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0245 0.039
Trypanosoma brucei glucose transporter 1E 0.0031 0.0455 0.7373
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0455 0.0752
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0431 0.0847
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0158 0.1166
Loa Loa (eye worm) hypothetical protein 0.0053 0.098 0.1923
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0155 0.1144
Trypanosoma brucei glucose transporter, putative 0.0031 0.0455 0.7373
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0245 0.0543
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0155 0.0688
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0825 0.1925
Schistosoma mansoni hypothetical protein 0.0015 0.0069 0.008
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1776 0.8837
Brugia malayi Pre-SET motif family protein 0.0224 0.5089 1
Toxoplasma gondii thioredoxin reductase 0.0038 0.0612 0.0908
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0446 0.1023
Loa Loa (eye worm) hypothetical protein 0.0069 0.1366 0.2682
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0155 0.0304
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0158 0.1166
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2129 0.3228
Leishmania major DNA polymerase kappa, putative 0.0019 0.0158 0.1166
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0158 0.0214
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2129 0.5032
Giardia lamblia DINP protein human, muc B family 0.0019 0.0158 0.3379
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0245 0.1894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0446 0.0736
Schistosoma mansoni sugar transporter 0.0014 0.0044 0.0042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0069 0.0126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.2349
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0044 0.0465
Loa Loa (eye worm) hypothetical protein 0.0038 0.0606 0.1187
Leishmania major trypanothione reductase 0.0038 0.0612 0.4963
Trypanosoma brucei glucose transporter, putative 0.0031 0.0455 0.7373
Entamoeba histolytica hypothetical protein 0.0023 0.0245 0.3081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0494 0.0968
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0044 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.003 0.0424 0.083
Schistosoma mansoni glucose transport protein 0.0101 0.2129 0.3202
Echinococcus granulosus GPCR family 2 0.0015 0.0069 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.2369
Leishmania major hypothetical protein, conserved 0.0015 0.0063 0.0375
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0825 0.1349
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.086 0.169
Echinococcus multilocularis solute carrier family 22 0.0014 0.0044 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2129 0.5032
Schistosoma mansoni bromodomain containing protein 0.0062 0.1191 0.1781
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0158 0.0336
Onchocerca volvulus 0.0047 0.0825 0.1349
Echinococcus multilocularis solute carrier family 22 0.0014 0.0044 0.0066
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0825 0.1225
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0693 0.116
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0155 0.033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083
Schistosoma mansoni hypothetical protein 0.0101 0.2129 0.3202
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1215 0.6014
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0825 0.1618
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.098 0.1461
Trypanosoma brucei trypanothione reductase 0.0038 0.0612 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0083

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.