TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.41 | Formula: C21H22N2O5
H donors: 1 H acceptors: 3 LogP: 1.86 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COCCN1Cc2c(C1=O)c(ccc2)C(=O)Nc1cccc(c1)C(=O)OCC
InChi: 1S/C21H22N2O5/c1-3-28-21(26)14-6-4-8-16(12-14)22-19(24)17-9-5-7-15-13-23(10-11-27-2)20(25)18(15)17/h4-9,12H,3,10-11,13H2,1-2H3,(H,22,24)
InChiKey: QBWSOBRXKMGOKA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0055	0.014	0.0164
Schistosoma mansoni	amine GPCR	0.0055	0.014	0.0177
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.014	0.0164
Trypanosoma cruzi	cytochrome P450, putative	0.0069	0.0188	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.014	0.0164
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0025	0.0041	0.1274
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0055	0.014	0.0177
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0016	0.0011	0.0003
Onchocerca volvulus		0.0055	0.014	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0025	0.004	0.0031
Onchocerca volvulus		0.0055	0.014	0.0136
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.0255	0.0246
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.014	0.0131
Brugia malayi	CXXC zinc finger family protein	0.0056	0.0143	0.0134
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0016	0.0011	0.0003
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.014	0.0177
Brugia malayi	neuropeptide F receptor	0.0055	0.014	0.0131
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0255	0.0332
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.014	0.0164
Schistosoma mansoni	histamine h1 receptor	0.0055	0.014	0.0177
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0055	0.014	0.0164
Echinococcus granulosus	serotonin receptor	0.0055	0.014	0.0177
Schistosoma mansoni	amine GPCR	0.0055	0.014	0.0177
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	Pre-SET motif family protein	0.0059	0.0155	0.0146
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0055	0.014	0.0177
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.004	0.0031
Echinococcus granulosus	fmrfamide receptor	0.0055	0.014	0.0177
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.004	0.0031
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.004	0.1227
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0025	0.0041	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0025	0.0041	1
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0025	0.0041	1
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.014	0.0164
Onchocerca volvulus		0.046	0.149	0.1964
Brugia malayi	Pre-SET motif family protein	0.0404	0.1305	0.1297
Schistosoma mansoni	amine GPCR	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	7TM GPCR rhodopsin	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	G-protein coupled receptor	0.0055	0.014	0.0131
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0148	0.0453	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0059
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0022	0.0013
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0123	0.0083
Trypanosoma cruzi	cytochrome P450, putative	0.0069	0.0188	0.0148
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0025	0.0041	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0055	0.014	0.0164
Echinococcus granulosus	ubiquitin specific protease 41	0.0148	0.0453	0.0598
Onchocerca volvulus		0.0055	0.014	0.0136
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0055	0.014	0.0131
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0025	0.0041	1
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.014	0.0177
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0148	0.0453	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.154	0.5091	0.5086
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0025	0.0041	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0453	0.0444
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.014	0.0177
Echinococcus multilocularis	G protein coupled receptor 139	0.0055	0.014	0.0164
Leishmania major	cytochrome p450-like protein	0.0069	0.0188	0.0148
Schistosoma mansoni	hypothetical protein	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0025	0.0041	0.1274
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.014	0.0164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.014	0.0164
Schistosoma mansoni	cpg binding protein	0.0059	0.0154	0.0195
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0025	0.0041	1
Trichomonas vaginalis	set domain proteins, putative	0.046	0.149	1
Onchocerca volvulus		0.0055	0.014	0.0136
Echinococcus multilocularis	serotonin receptor	0.0055	0.014	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0148	0.0453	0.3037
Echinococcus granulosus	histone lysine methyltransferase setb	0.0059	0.0155	0.0196
Schistosoma mansoni	adenoreceptor	0.0055	0.014	0.0177
Echinococcus granulosus	dro:myosuppressin receptor	0.0055	0.014	0.0177
Leishmania major	cytochrome p450-like protein	0.0025	0.0041	0.0001
Loa Loa (eye worm)	melatonin receptor type 1A	0.0055	0.014	0.0131
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0025	0.0041	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0025	0.004	0.0031
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0055	0.014	0.0177
Echinococcus multilocularis	allatostatin A receptor	0.0055	0.014	0.0164
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.014	0.0177
Onchocerca volvulus		0.0055	0.014	0.0136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.0255	0.0246
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0025	0.0041	0.1274
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0148	0.0453	0.0414
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0025	0.0041	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0025	0.0041	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.2416	0.801	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0148	0.0453	0.0598
Schistosoma mansoni	biogenic amine receptor	0.0055	0.014	0.0177
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0055	0.014	0.0131
Plasmodium vivax	ataxin-2 like protein, putative	0.0049	0.0123	0.7649
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.001
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	cpg binding protein	0.0059	0.0154	0.0195
Echinococcus granulosus	neuropeptide receptor	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.014	0.0177
Onchocerca volvulus		0.0055	0.014	0.0136
Echinococcus granulosus	7tm_1 domain containing protein	0.0055	0.014	0.0177
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0255	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0041	0.0032
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0055	0.014	0.0164
Schistosoma mansoni	cpg binding protein	0.0056	0.0143	0.0181
Brugia malayi	putative neuropeptide receptor NPR1	0.0055	0.014	0.0131
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0055	0.014	0.0131
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.004	0.9682
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.014	0.0131
Echinococcus granulosus	cytochrome P450 2K1	0.0025	0.0041	0.0043
Echinococcus multilocularis	neuropeptide s receptor	0.0055	0.014	0.0164
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0148	0.0453	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	CYP4Cod1	0.0069	0.0188	0.0179
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0011	0.0003
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Onchocerca volvulus		0.0055	0.014	0.0136
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0255	0.0332
Onchocerca volvulus		0.0055	0.014	0.0136
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.014	0.0164
Brugia malayi	G protein-coupled receptor	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.001
Echinococcus multilocularis	neuropeptide receptor A26	0.0055	0.014	0.0164
Schistosoma mansoni	biogenic amine receptor	0.0055	0.014	0.0177
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0055	0.014	0.0177
Loa Loa (eye worm)	cytochrome P450 family protein	0.0069	0.0188	0.0179
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0059	0.0155	0.4146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.014	0.0177
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.014	0.0177
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0016	0.0011	0.0003
Echinococcus granulosus	somatostatin receptor	0.0055	0.014	0.0177
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.004	0.1227
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Plasmodium vivax	SET domain protein, putative	0.0059	0.0155	1
Onchocerca volvulus		0.0055	0.014	0.0136
Brugia malayi	hypothetical protein	0.0049	0.0123	0.0114
Echinococcus multilocularis	g-protein coupled receptor	0.0055	0.014	0.0164
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0025	0.0041	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0155	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.014	0.0164
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0404	0.1305	0.1297
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0148	0.0453	0.0415
Schistosoma mansoni	hypothetical protein	0.0166	0.0511	0.0676
Schistosoma mansoni	biogenic amine receptor	0.0055	0.014	0.0177
Echinococcus multilocularis	ubiquitin specific protease 41	0.0148	0.0453	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.001
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0025	0.0041	0.1274
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0025	0.0041	0.1274
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.014	0.0131
Schistosoma mansoni	hypothetical protein	0.0022	0.0032	0.0031
Loa Loa (eye worm)	hypothetical protein	0.3014	1	1
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0025	0.0041	0.1274
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0155	0.0146
Mycobacterium leprae	Conserved hypothetical protein	0.0025	0.0041	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.014	0.0164
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0055	0.014	0.0177
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	g-protein coupled receptor	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	neuropeptide FF receptor 2	0.0055	0.014	0.0177
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0255	0.0308
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.014	0.0164
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.014	0.0177
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0055	0.014	0.0177
Schistosoma mansoni	amine GPCR	0.0055	0.014	0.0177
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0055	0.014	0.0177
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0055	0.014	0.0164
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0025	0.0041	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.014	0.0177
Leishmania major	C-8 sterol isomerase-like protein	0.3014	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0025	0.0041	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0123	0.0114
Schistosoma mansoni	hypothetical protein	0.0055	0.014	0.0177
Leishmania major	cytochrome p450-like protein	0.0025	0.0041	0.0001
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0025	0.0041	0.1274
Schistosoma mansoni	hypothetical protein	0.0033	0.0068	0.008
Onchocerca volvulus		0.0056	0.0143	0.014
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.014	0.0177
Brugia malayi	hypothetical protein	0.0032	0.0064	0.0056
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.014	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Onchocerca volvulus		0.0055	0.014	0.0136
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.014	0.0177
Echinococcus granulosus	allatostatin A receptor	0.0055	0.014	0.0177
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.014	0.0177
Brugia malayi	G-protein coupled receptor	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0155	0.0196
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0123	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0105	0.0096
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.014	0.0164
Onchocerca volvulus		0.0059	0.0155	0.0155
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0025	0.0041	0.1274
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.014	0.0177
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Echinococcus granulosus	g protein coupled receptor	0.0055	0.014	0.0177
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0055	0.014	0.0136
Brugia malayi	Cytochrome P450 family protein	0.0069	0.0188	0.0179
Loa Loa (eye worm)	cytochrome P450	0.0025	0.0041	0.0032
Schistosoma mansoni	cytochrome P450	0.0025	0.0041	0.0043
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0255	0.0308
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.0453	0.3037
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0123	0.0083
Brugia malayi	Serotonin receptor	0.0055	0.014	0.0131
Schistosoma mansoni	myosin xvIII	0.0055	0.014	0.0177
Echinococcus multilocularis	vesicular acetylcholine transporter	0.2242	0.7428	0.9273
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0123	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0069	0.0188	0.0179
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.014	0.0131
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0119	0.011
Echinococcus granulosus	vesicular acetylcholine transporter	0.2242	0.7428	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.014	0.0177
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0055	0.014	0.0131
Brugia malayi	GnHR receptor homolog	0.0055	0.014	0.0131
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0119	0.011
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0148	0.0453	0.0598
Schistosoma mansoni	neuropeptide receptor	0.0055	0.014	0.0177
Brugia malayi	sulfakinin receptor protein	0.0055	0.014	0.0131
Brugia malayi	vesicular acetylcholine transporter unc-17	0.2242	0.7428	0.7425
Schistosoma mansoni	hypothetical protein	0.0025	0.0041	0.0043
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.014	0.0164
Echinococcus multilocularis	geminin	0.0166	0.0511	0.0627
Echinococcus granulosus	sex peptide receptor	0.0055	0.014	0.0177
Brugia malayi	ORL1-like opioid receptor	0.0055	0.014	0.0131
Trypanosoma brucei	cytochrome P450, putative	0.0069	0.0188	0.0148
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0148	0.0453	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	g protein coupled receptor	0.0055	0.014	0.0177
Toxoplasma gondii	LsmAD domain-containing protein	0.0049	0.0123	0.2988
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0107	0.0316	1
Echinococcus granulosus	neuropeptide s receptor	0.0055	0.014	0.0177
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.014	0.0164
Schistosoma mansoni	vesicular acetylcholine transporter	0.2242	0.7428	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.014	0.0177
Schistosoma mansoni	hypothetical protein	0.0166	0.0511	0.0676
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0025	0.0041	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0055	0.014	0.0177
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0025	0.0041	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	Dopamine receptor protein 2	0.0055	0.014	0.0131
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0148	0.0453	1
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0025	0.0041	0.1274
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0019	0.1346
Echinococcus granulosus	neuropeptide receptor	0.0055	0.014	0.0177
Onchocerca volvulus		0.0055	0.014	0.0136
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0068	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.014	0.0164
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	follicle stimulating hormone receptor	0.0055	0.014	0.0131
Echinococcus multilocularis	conserved hypothetical protein	0.0742	0.2431	0.3027
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0025	0.0041	0.1274
Echinococcus multilocularis	sex peptide receptor	0.0055	0.014	0.0164
Schistosoma mansoni	opsin-like receptor	0.0055	0.014	0.0177
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0055	0.014	0.0131
Loa Loa (eye worm)	TYRA-2 protein	0.0055	0.014	0.0131
Onchocerca volvulus		0.0055	0.014	0.0136
Schistosoma mansoni	cpg binding protein	0.0059	0.0154	0.0195
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0059	0.0155	0.0182
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0025	0.0041	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.004	0.1227
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0119	0.011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0055	0.014	0.0177
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.014	0.0177
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0148	0.0453	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0022	0.0018
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.014	0.0164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.014	0.0164
Brugia malayi	neuropeptide F receptor	0.0055	0.014	0.0131
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0025	0.0041	1
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.014	0.0164
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0055	0.014	0.0164
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0025	0.0041	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.001
Echinococcus multilocularis	somatostatin receptor	0.0055	0.014	0.0164
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0055	0.014	0.0177
Echinococcus granulosus	neuropeptide receptor A26	0.0055	0.014	0.0177
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0025	0.0041	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.014	0.0177
Schistosoma mansoni	opsin-like receptor	0.0055	0.014	0.0177
Schistosoma mansoni	neuropeptide receptor	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0025	0.004	0.0031
Mycobacterium ulcerans	hypothetical protein	0.0025	0.004	0.1227
Trypanosoma brucei	PAB1-binding protein , putative	0.0049	0.0123	0.0083
Brugia malayi	Dopamine receptor	0.0055	0.014	0.0131
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0056	0.0143	0.0134
Brugia malayi	Dopamine receptor protein 1	0.0055	0.014	0.0131
Schistosoma mansoni	neuropeptide f receptor 76f	0.0055	0.014	0.0177
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0055	0.014	0.0164
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0055	0.014	0.0131
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Trypanosoma brucei	C-8 sterol isomerase, putative	0.3014	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0059	0.0155	0.0196
Onchocerca volvulus		0.0055	0.014	0.0136
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.014	0.0177
Echinococcus granulosus	g protein coupled receptor	0.0055	0.014	0.0177
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.004	0.1227
Leishmania major	hypothetical protein, conserved	0.0049	0.0123	0.0083
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0148	0.0453	0.0414
Echinococcus multilocularis		0.0025	0.0041	0.004
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0025	0.0041	0.1274
Schistosoma mansoni	neuropeptide receptor	0.0055	0.014	0.0177
Schistosoma mansoni	hypothetical protein	0.0055	0.014	0.0177
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0155	0.0196
Mycobacterium leprae	putative cytochrome p450	0.0025	0.0041	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.014	0.0164
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0025	0.0041	0.1274
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0056	0.0144	0.0181
Brugia malayi	Cytochrome P450 family protein	0.0069	0.0188	0.0179
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.014	0.0177
Schistosoma mansoni	hypothetical protein	0.0055	0.014	0.0177
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0025	0.0041	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0148	0.0453	0.0555
Echinococcus multilocularis	orexin receptor type 2	0.0055	0.014	0.0164
Brugia malayi	AKH receptor	0.0055	0.014	0.0131
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.014	0.0164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0255	0.0332
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0032	0.0031
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0055	0.014	0.0164
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.2242	0.7428	1
Schistosoma mansoni	opsin-like receptor	0.0055	0.014	0.0177
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.004	0.9682
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0025	0.0041	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.014	0.0164
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0119	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.014	0.0164
Echinococcus granulosus	G protein coupled receptor 139	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.014	0.0164
Schistosoma mansoni	growth hormone secretagogue receptor	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.014	0.0164
Onchocerca volvulus		0.0055	0.014	0.0136
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.004	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.001
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	cytochrome P450	0.0025	0.0041	0.0032
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.014	0.0177
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0025	0.0041	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0055	0.014	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	putative neuropeptide receptor	0.0055	0.014	0.0131
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0055	0.014	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.014	0.0177
Schistosoma mansoni	neuropeptide receptor	0.0055	0.014	0.0177
Brugia malayi	Melatonin receptor type 1A	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.004	0.1227
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0025	0.0041	0.1274
Onchocerca volvulus		0.0055	0.014	0.0136
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0025	0.0041	0.1274
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.004	0.1227
Echinococcus granulosus	orexin receptor type 2	0.0055	0.014	0.0177
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.014	0.0177
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.014	0.0177
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0032	0.0029
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0069	0.0188	1
Brugia malayi	RE15519p	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0148	0.0453	0.3037
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0025	0.0041	1
Onchocerca volvulus		0.0055	0.014	0.0136
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0016	0.0011	0.0003
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.014	0.0177
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0255	0.0332
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.004	0.0031
Echinococcus multilocularis	serotonin receptor	0.0055	0.014	0.0164
Brugia malayi	Cytochrome P450 family protein	0.0062	0.0166	0.0157
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0025	0.0041	0.1274
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.3014	1	1
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0022	0.0013
Onchocerca volvulus		0.0055	0.014	0.0136
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0022	0.0017
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.014	0.0177
Schistosoma mansoni	amine GPCR	0.0055	0.014	0.0177
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0055	0.014	0.0177
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0055	0.014	0.0164
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.012	0.0358	0.047
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Brugia malayi	Serotonin receptor	0.1867	0.6178	0.6174
Brugia malayi	larval opioid receptor	0.0055	0.014	0.0131
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0055	0.014	0.0136
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0055	0.014	0.0177
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.014	0.0164
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0059	0.0155	0.0182
Loa Loa (eye worm)	cytochrome P450 family protein	0.0062	0.0166	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.014	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	hypothetical protein	0.0797	0.2613	0.351
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0055	0.014	0.0131
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.2242	0.7428	0.7425
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0025	0.0041	1
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0025	0.0041	1
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0025	0.0041	0.1274
Brugia malayi	G protein-coupled receptor F59B2.13	0.0055	0.014	0.0131
Brugia malayi	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0148	0.0453	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.014	0.0177
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.014	0.0177
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0055	0.014	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0055	0.014	0.0164
Echinococcus granulosus	geminin	0.0166	0.0511	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.0131
Echinococcus multilocularis	cpg binding protein	0.0059	0.0154	0.0181

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 801729