Detailed information for compound 807914

Basic information

Technical information
  • TDR Targets ID: 807914
  • Name: (Z)-4-[[4-(6-methyl-1,3-benzothiazol-2-yl)phe nyl]amino]-4-oxobut-2-enoic acid
  • MW: 338.38 | Formula: C18H14N2O3S
  • H donors: 2 H acceptors: 4 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C=CC(=O)Nc1ccc(cc1)c1sc2c(n1)ccc(c2)C
  • InChi: 1S/C18H14N2O3S/c1-11-2-7-14-15(10-11)24-18(20-14)12-3-5-13(6-4-12)19-16(21)8-9-17(22)23/h2-10H,1H3,(H,19,21)(H,22,23)/b9-8-
  • InChiKey: HDYOIHVTWSZHQB-HJWRWDBZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-4-[[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]amino]-4-oxo-but-2-enoic acid
  • (Z)-4-keto-4-[[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]amino]but-2-enoic acid
  • BIM-0013356.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0402 0.6849
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0251 0.0253
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0601 0.0597
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0585 0.06
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0402 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0606 0.1227
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0027 0.0041
Giardia lamblia Sugar-proton symporter 0.0015 0.0205 0.346
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0585 0.06
Schistosoma mansoni cpg binding protein 0.0035 0.0644 0.066
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0704 1
Schistosoma mansoni hypothetical protein 0.0125 0.2612 0.2675
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0585 1
Brugia malayi RNA binding protein 0.0062 0.1219 0.2473
Trypanosoma cruzi ISWI complex protein 0.0015 0.0195 0.2736
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.097 0.099
Schistosoma mansoni glucose transporter 0.0015 0.0205 0.021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0601 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.061 0.108
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0205 0.2874
Schistosoma mansoni hypothetical protein 0.0017 0.0251 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0402 0.0408
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0068 0.007
Trichomonas vaginalis sugar transporter, putative 0.0034 0.061 0.108
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.06 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus multilocularis solute carrier family 22 0.0015 0.0205 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0034 0.061 0.108
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0251 0.0253
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0205 0.041
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0585 0.9752
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.06 0.122
Leishmania major glucose transporter, lmgt2 0.0034 0.061 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Trypanosoma cruzi hexose transporter 0.0034 0.061 0.8651
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0041
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0402 0.5689
Trypanosoma brucei glucose transporter 2A 0.0034 0.061 0.2323
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0601 0.0597
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0601 0.0597
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0585 0.1037
Schistosoma mansoni protein kinase 0.0033 0.06 0.0615
Loa Loa (eye worm) hypothetical protein 0.0037 0.0687 0.1396
Echinococcus granulosus GPCR family 2 0.0017 0.0251 0.0253
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0274 0.386
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0402 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1219 0.1249
Onchocerca volvulus 0.0034 0.0606 0.0742
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Loa Loa (eye worm) RNA binding protein 0.0062 0.1219 0.2478
Schistosoma mansoni bromodomain containing protein 0.0063 0.1257 0.1288
Echinococcus multilocularis smad 0.0009 0.0066 0.0064
Schistosoma mansoni glucose transport protein 0.0109 0.2256 0.2311
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0251 0.0503
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Giardia lamblia Hexose transporter 0.0015 0.0205 0.346
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0555 0.0565
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1219 0.2478
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1219 0.1249
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0205 0.6328
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0205 0.5052
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0205 0.0201
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.06 0.0611
Loa Loa (eye worm) hypothetical protein 0.0027 0.0451 0.0917
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0205 0.0772
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0205 0.2874
Toxoplasma gondii sugar transporter ST3 0.0015 0.0205 0.0305
Schistosoma mansoni protein kinase 0.0033 0.06 0.0615
Schistosoma mansoni zinc finger protein 0.0015 0.0195 0.02
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0066 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.06 0.0611
Mycobacterium ulcerans sugar transporter 0.0015 0.0205 0.5052
Schistosoma mansoni glucose transport protein 0.0109 0.2256 0.2311
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0233 0.0235
Brugia malayi major facilitator superfamily protein 0.0015 0.0205 0.041
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0027 0.0041
Schistosoma mansoni sugar transporter 0.0015 0.0205 0.021
Brugia malayi Sugar transporter family protein 0.0015 0.0205 0.041
Trichomonas vaginalis glucose transporter, putative 0.0034 0.061 0.108
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1262 0.1904
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0402 0.0412
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0322 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1075 0.218
Schistosoma mansoni hypothetical protein 0.0038 0.0694 0.071
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0402 0.0811
Trichomonas vaginalis sugar transporter, putative 0.0034 0.061 0.108
Brugia malayi MH2 domain containing protein 0.0009 0.0066 0.0127
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0601 0.0597
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0205 0.0417
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0402 0.5689
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2256 0.2308
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0246 0.0499
Schistosoma mansoni cpg binding protein 0.0035 0.0644 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Plasmodium vivax SET domain protein, putative 0.0034 0.0606 0.0603
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Schistosoma mansoni sugar transporter 0.0015 0.0205 0.021
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0704 1
Schistosoma mansoni glucose transport protein 0.0109 0.2256 0.2311
Brugia malayi MH1 domain containing protein 0.0009 0.0066 0.0127
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0004 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0606 0.0621
Trypanosoma cruzi hexose transporter, putative 0.0034 0.061 0.8651
Brugia malayi MH2 domain containing protein 0.0009 0.0066 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0606 0.0621
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Trypanosoma brucei glucose transporter, putative 0.0034 0.061 0.2323
Trypanosoma brucei glucose transporter, putative 0.0034 0.061 0.2323
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0704 0.106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.097 0.0993
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0109 0.2256 0.2308
Loa Loa (eye worm) sugar transporter 0.0015 0.0205 0.0417
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0205 0.0417
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0555 0.0565
Echinococcus multilocularis solute carrier family 22 0.0015 0.0205 0.0206
Onchocerca volvulus 0.0262 0.5614 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1219 0.2478
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0111 0.011
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0111 0.0225
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0606 0.0618
Toxoplasma gondii sugar transporter ST2 0.0015 0.0205 0.0305
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0601 0.0597
Brugia malayi TAR-binding protein 0.0062 0.1219 0.2473
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.061 0.2323
Schistosoma mansoni sugar transporter 0.0015 0.0205 0.021
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2256 0.2308
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0205 0.0359
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2256 0.2308
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0205 0.041
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus multilocularis solute carrier family 22 0.0015 0.0205 0.0206
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0066 0.0134
Plasmodium vivax sugar transporter, putative 0.0015 0.0205 0.0201
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0402 0.0399
Loa Loa (eye worm) Smad1 0.0009 0.0066 0.0134
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Leishmania major glucose transporter, lmgt1 0.0034 0.061 0.8651
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0606 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.06 0.0611
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0402 0.071
Loa Loa (eye worm) hypothetical protein 0.004 0.0737 0.1499
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0205 0.6328
Brugia malayi MH2 domain containing protein 0.0132 0.2757 0.5602
Loa Loa (eye worm) hypothetical protein 0.0033 0.0585 0.119
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0041
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0601 0.0597
Schistosoma mansoni smad1 5 8 and 0.0009 0.0066 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1075 0.218
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.061 0.2323
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0205 0.021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.097 0.0993
Loa Loa (eye worm) hypothetical protein 0.0038 0.0694 0.141
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.2757 0.5605
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0585 0.1184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.061 0.108
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0704 1
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0205 0.0359
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0251 0.0503
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0601 0.0597
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.097 0.099
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1369 0.1403
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.4918 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2256 0.2308
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus multilocularis General substrate transporter 0.0093 0.1921 0.1964
Entamoeba histolytica hypothetical protein 0.0024 0.0402 0.6679
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0205 0.2874
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0205 0.0206
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0205 0.5052
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0122 0.2978
Schistosoma mansoni hypothetical protein 0.0451 0.9762 1
Trichomonas vaginalis set domain proteins, putative 0.0262 0.5614 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1219 0.2473
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1219 0.1249
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1219 0.1249
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0322 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus multilocularis zinc finger protein 0.0021 0.0326 0.033
Loa Loa (eye worm) hypothetical protein 0.005 0.097 0.1972
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0122 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0176 0.3726 0.3724
Trypanosoma cruzi hexose transporter, putative 0.0034 0.061 0.8651
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Loa Loa (eye worm) hypothetical protein 0.0033 0.0585 0.119
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0066 0.0064
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2256 0.2308
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0233 0.0238
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Leishmania major hypothetical protein, conserved 0.0015 0.0205 0.2874
Schistosoma mansoni sugar transporter 0.0015 0.0205 0.021
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0402 0.6849
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0585 0.0596
Loa Loa (eye worm) hypothetical protein 0.0043 0.0818 0.1662
Schistosoma mansoni hypothetical protein 0.0017 0.0251 0.0257
Onchocerca volvulus 0.0032 0.0564 0.0664
Loa Loa (eye worm) hypothetical protein 0.0024 0.0402 0.0817
Trichomonas vaginalis helicase, putative 0.0007 0.0027 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Trypanosoma brucei glucose transporter, putative 0.0034 0.061 0.2323
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.061 0.8651
Echinococcus granulosus solute carrier family 22 0.0015 0.0205 0.0206
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.061 0.2323
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0389 0.0395
Brugia malayi hypothetical protein 0.0015 0.0205 0.041
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.06 0.122
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.0122 0.2978
Echinococcus multilocularis Smad4 0.0009 0.0066 0.0064
Schistosoma mansoni cpg binding protein 0.0032 0.0564 0.0578
Echinococcus granulosus tar DNA binding protein 0.0062 0.1219 0.1245
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1219 0.1249
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0068 0.0066
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0402 0.1528
Loa Loa (eye worm) hypothetical protein 0.0055 0.1075 0.2186
Entamoeba histolytica protein kinase, putative 0.0033 0.06 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0402 0.0412
Toxoplasma gondii facilitative glucose transporter GT1 0.0109 0.2256 0.3408
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.06 0.0611
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0585 0.1184
Echinococcus multilocularis cpg binding protein 0.0035 0.0644 0.0656
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0402 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0205 1
Schistosoma mansoni hypothetical protein 0.0017 0.0251 0.0257
Plasmodium falciparum hexose transporter 0.0109 0.2256 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Schistosoma mansoni smad1 5 8 and 0.0009 0.0066 0.0068
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0389 0.0399
Trypanosoma brucei glucose transporter, putative 0.0034 0.061 0.2323
Leishmania major glucose transporter, lmgt3 0.0034 0.061 0.8651
Trypanosoma brucei glucose transporter, putative 0.0034 0.061 0.2323
Echinococcus granulosus cpg binding protein 0.0035 0.0644 0.0656
Brugia malayi PHD-finger family protein 0.0026 0.044 0.0887
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0205 0.0305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0251 0.051
Trypanosoma brucei glucose transporter, putative 0.0034 0.061 0.2323
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0389 0.0395
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.2757 0.5605
Echinococcus granulosus solute carrier family 22 0.0015 0.0205 0.0206
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0601 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0205 0.0359
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0704 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Trypanosoma brucei glucose transporter, putative 0.0034 0.061 0.2323
Brugia malayi Bromodomain containing protein 0.0037 0.0685 0.1387
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0149 0.0295
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1181 0.1206
Trypanosoma brucei sugar transporter, putative 0.0015 0.0205 0.0772
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0066 0.0134
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0068 0.0066
Plasmodium falciparum protein kinase 7 0.0307 0.6613 0.6612
Schistosoma mansoni hypothetical protein 0.0017 0.0251 0.0257
Loa Loa (eye worm) hypothetical protein 0.0033 0.06 0.122
Brugia malayi major facilitator superfamily protein 0.0015 0.0205 0.041
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0004 0.0007
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0233 0.0235
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0066 0.0064
Echinococcus granulosus Smad4 0.0009 0.0066 0.0064
Echinococcus granulosus solute carrier family 22 0.0015 0.0205 0.0206
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.06 0.2287
Brugia malayi Cam kinase protein 1 0.0033 0.06 0.1214
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0322 0.5469
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Trypanosoma cruzi hexose transporter, putative 0.0034 0.061 0.8651
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.06 0.0611
Schistosoma mansoni smad 0.0009 0.0066 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0176 0.3726 0.5632
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0111 0.011
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0205 0.5052
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0309 0.0628
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0205 0.041
Trypanosoma cruzi ISWI complex protein 0.0015 0.0195 0.2736
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0336 0.0593
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0041
Loa Loa (eye worm) sugar transporter 0.0109 0.2256 0.4587
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1181 0.1206
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Brugia malayi Sugar transporter family protein 0.0015 0.0205 0.041
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Plasmodium falciparum mitogen-activated protein kinase 2 0.0176 0.3726 0.3724
Schistosoma mansoni hypothetical protein 0.002 0.0309 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0041
Plasmodium vivax hexose transporter 0.0109 0.2256 0.2253
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0233 0.0238
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0565 0.0575
Plasmodium vivax CDK-related protein kinase 6, putative 0.0462 1 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0205 0.0206
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2256 0.2308
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0205 0.2874
Brugia malayi Smad1 0.0009 0.0066 0.0127
Trypanosoma brucei glucose transporter 1E 0.0034 0.061 0.2323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0041
Leishmania major protein kinase, putative 0.0033 0.06 0.8517
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0066 0.0064
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0601 0.0903
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0251 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.06 0.0611
Echinococcus granulosus General substrate transporter 0.0093 0.1921 0.1964
Schistosoma mansoni hypothetical protein 0.0109 0.2256 0.2311
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1075 0.2186
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0205 0.0359
Schistosoma mansoni Smad4 0.0009 0.0066 0.0068
Schistosoma mansoni protein kinase 0.0033 0.06 0.0615
Trichomonas vaginalis glucose transporter, putative 0.0034 0.061 0.108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0251 0.0253
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0704 0.0701
Leishmania major hypothetical protein, conserved 0.0015 0.0195 0.2736
Brugia malayi hypothetical protein 0.0015 0.0205 0.041
Toxoplasma gondii sugar transporter ST1 0.0015 0.0205 0.0305
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0205 0.0206
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.06 0.1214
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0205 0.0206
Echinococcus granulosus smad 0.0009 0.0066 0.0064
Trypanosoma brucei RNA helicase, putative 0.0125 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1376 0.2798
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0635 0.0647
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1219 0.1245
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0251 0.051
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0205 0.0359
Echinococcus granulosus dnaJ subfamily B 0.0451 0.9762 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0066 0.0068
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0704 0.2686
Brugia malayi CXXC zinc finger family protein 0.0032 0.0564 0.114
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.06 0.1063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0704 1
Schistosoma mansoni hypothetical protein 0.0015 0.0195 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0041
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0564 0.1147
Echinococcus multilocularis solute carrier family 22 0.0015 0.0205 0.0206
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0163 0.0332
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.9762 1
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0205 0.0359
Echinococcus granulosus solute carrier family 22 0.0015 0.0205 0.0206
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0635 0.0647
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0417
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0585 0.0596
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0402 0.0399
Brugia malayi Bromodomain containing protein 0.0075 0.1507 0.3059
Brugia malayi Pre-SET motif family protein 0.023 0.4918 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0402 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0205 0.0359
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0601 0.0597
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0601 0.0903
Brugia malayi Sugar transporter family protein 0.0109 0.2256 0.4583
Trypanosoma brucei ISWI complex protein 0.0015 0.0195 0.0735
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0402 0.0408
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0694 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0205 0.0359
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2256 0.2308
Toxoplasma gondii protein kinase, putative 0.0307 0.6613 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.061 0.2323
Brugia malayi hypothetical protein 0.0015 0.0205 0.041
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0068 0.0066
Echinococcus multilocularis GPCR, family 2 0.0017 0.0251 0.0253
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0004 0.0004
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0585 1
Brugia malayi MH1 domain containing protein 0.0009 0.0066 0.0127
Schistosoma mansoni smad1 5 8 and 0.0009 0.0066 0.0068
Schistosoma mansoni zinc finger protein 0.0021 0.0326 0.0334
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0068 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.2256 0.4015
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0205 0.0359
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.06 0.0611
Echinococcus granulosus zinc finger protein 0.0021 0.0326 0.033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0041
Entamoeba histolytica protein kinase, putative 0.0033 0.06 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.06 0.0615

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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