Detailed information for compound 814487

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.599 | Formula: C23H27FN2O5S2
  • H donors: 0 H acceptors: 3 LogP: 3.7 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN(S(=O)(=O)c1sc2c(c1C(=O)OC)CCN(C2)Cc1ccc(c(c1)OC)F)CC=C
  • InChi: 1S/C23H27FN2O5S2/c1-5-10-26(11-6-2)33(28,29)23-21(22(27)31-4)17-9-12-25(15-20(17)32-23)14-16-7-8-18(24)19(13-16)30-3/h5-8,13H,1-2,9-12,14-15H2,3-4H3
  • InChiKey: SPCNZPLYLWKRLG-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii subtilisin SUB10 0.0111 0.0213 0.0169
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0025 0.0087
Echinococcus granulosus neuroendocrine convertase 2 0.0536 0.1331 0.6509
Echinococcus granulosus aminopeptidase N 0.0121 0.0238 0.1132
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.0041 0.0163
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0111 0.0213 0.155
Plasmodium falciparum plasmepsin II 0.0166 0.0356 0.1067
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0476 0.1171 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0019 0.0062
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0269 0.0774
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0181 0.0398 0.2342
Onchocerca volvulus 0.0111 0.0213 0.8863
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0111 0.0213 0.0199
Plasmodium falciparum plasmepsin VIII, putative 0.0093 0.0165 0.0422
Entamoeba histolytica aminopeptidase, putative 0.0036 0.0014 0.0156
Schistosoma mansoni cathepsin D (A01 family) 0.0352 0.0845 0.0832
Brugia malayi hypothetical protein 0.0058 0.0075 0.0365
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.0041 0.0163
Plasmodium falciparum plasmepsin VI 0.0166 0.0356 0.1067
Toxoplasma gondii subtilisin SUB9 0.0111 0.0213 0.0169
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0014 0.0036
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.014 0.029 0.216
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0043 0.0035 0.0158
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0166 0.0356 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0213 0.1554
Brugia malayi endoprotease bli-4 precursor 0.0806 0.204 1
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0523 0.1295 0.3968
Trypanosoma brucei subtilisin peptidase 0.0111 0.0213 0.1643
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0582 0.4446
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Loa Loa (eye worm) aspartyl protease 6 0.0093 0.0165 0.0807
Loa Loa (eye worm) hypothetical protein 0.0093 0.0165 0.0807
Brugia malayi Guanylate kinase family protein 0.0056 0.0068 0.0332
Toxoplasma gondii subtilisin SUB12 0.0111 0.0213 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0521 0.1291 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0093 0.0165 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0093 0.0165 0.015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0582 0.4446
Trypanosoma brucei N-myristoyltransferase 0.0181 0.0398 0.3069
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0166 0.0356 0.1713
Brugia malayi aspartic protease BmAsp-1, identical 0.0093 0.0165 0.0807
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0014 0.011
Schistosoma mansoni tyrosine kinase 0.0165 0.0355 0.0341
Schistosoma mansoni site-1 peptidase (S08 family) 0.0111 0.0213 0.0199
Trypanosoma brucei unspecified product 0.0033 0.0009 0.0067
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0011 0.0017
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0132 0.0269 0.0255
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0043 0.0035 0.013
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0014 0.003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0111 0.0213 0.1043
Schistosoma mansoni tyrosine kinase 0.0168 0.0363 0.0349
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0523 0.1295 0.4223
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0014 0.007
Plasmodium vivax aspartyl proteinase, putative 0.0166 0.0356 0.1067
Loa Loa (eye worm) hypothetical protein 0.0108 0.0205 0.1007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0582 0.4446
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0111 0.0213 0.1007
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Echinococcus multilocularis adam 0.0058 0.0075 0.0399
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0093 0.0165 0.015
Loa Loa (eye worm) subtilase 0.0111 0.0213 0.1043
Schistosoma mansoni tumor necrosis factor receptor related 0.0043 0.0035 0.002
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0171 0.037 0.289
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0213 0.1554
Echinococcus granulosus membrane bound transcription factor site 1 0.0111 0.0213 0.1007
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0014 0.0036
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0132 0.0269 0.1991
Plasmodium falciparum plasmepsin X 0.0093 0.0165 0.0422
Loa Loa (eye worm) hypothetical protein 0.0166 0.0356 0.1746
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0166 0.0356 0.2093
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0166 0.0356 0.1746
Brugia malayi protein-tyrosine kinase 0.0037 0.0019 0.0091
Plasmodium vivax subtilisin-like protease 1 0.1176 0.3014 1
Schistosoma mansoni cell polarity protein 0.0047 0.0045 0.0031
Schistosoma mansoni N-myristoyltransferase 0.0181 0.0398 0.0384
Plasmodium vivax aspartyl proteinase, putative 0.0093 0.0165 0.0422
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0806 0.204 0.2028
Plasmodium falciparum subtilisin-like protease 1 0.1176 0.3014 1
Brugia malayi SRC-1 0.0046 0.0041 0.0202
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0025 0.0087
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Plasmodium vivax aspartyl protease, putative 0.0093 0.0165 0.0422
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0036 0.0014 0.0036
Loa Loa (eye worm) endoprotease bli-4 0.0806 0.204 1
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0093 0.0165 0.015
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0045 0.0039 0.0213
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0035 0.013
Brugia malayi Peptidase family M1 containing protein 0.0121 0.0238 0.1168
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Echinococcus multilocularis neuroendocrine convertase 2 0.0536 0.1331 0.7955
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0166 0.0356 0.2678
Loa Loa (eye worm) hypothetical protein 0.0806 0.204 1
Schistosoma mansoni tyrosine kinase 0.0312 0.074 0.0727
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0476 0.1171 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0036 0.0014 0.011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0093 0.0165 0.015
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0521 0.1291 0.7718
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0213 0.1554
Echinococcus multilocularis epidermal growth factor receptor 0.0312 0.074 0.4405
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0019 0.0051
Toxoplasma gondii subtilisin SUB1 0.1176 0.3014 1
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0523 0.1295 1
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0476 0.1171 1
Plasmodium falciparum plasmepsin I 0.0166 0.0356 0.1067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Schistosoma mansoni tyrosine kinase 0.0168 0.0363 0.0349
Schistosoma mansoni palmitoyl-protein thioesterase 0.0083 0.0139 0.0125
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0523 0.1295 0.635
Echinococcus granulosus adam 0.0058 0.0075 0.0326
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0009 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Brugia malayi Eukaryotic aspartyl protease family protein 0.0093 0.0165 0.0807
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0111 0.0213 0.123
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0011 0.0014
Echinococcus multilocularis palmitoyl protein thioesterase 1 0.0083 0.0139 0.0789
Toxoplasma gondii subtilisin SUB11 0.0111 0.0213 0.0169
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0093 0.0165 0.015
Plasmodium vivax plasmepsin V, putative 0.0093 0.0165 0.0422
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0041 0.0163
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0041 0.0199
Mycobacterium ulcerans transcriptional regulator NrdR 0.0047 0.0045 0.0264
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0038 0.0181
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0025 0.0196
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0038 0.0024
Schistosoma mansoni tyrosine kinase 0.01 0.0185 0.0171
Toxoplasma gondii subtilisin SUB8 0.0111 0.0213 0.0169
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0132 0.0269 0.2078
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0132 0.0269 0.1991
Brugia malayi hypothetical protein 0.0093 0.0165 0.0807
Echinococcus granulosus furin 0.0806 0.204 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0025 0.0087
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.0041 0.0163
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Plasmodium vivax aspartyl protease, putative 0.0093 0.0165 0.0422
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0269 0.1989
Loa Loa (eye worm) proprotein convertase 2 0.0251 0.0582 0.2853
Trypanosoma cruzi N-myristoyl transferase, putative 0.0181 0.0398 0.2992
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0181 0.0398 0.1916
Trichomonas vaginalis N-myristoyl transferase, putative 0.0181 0.0398 0.3001
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.0041 0.0199
Brugia malayi Furin-like cysteine rich region family protein 0.0312 0.074 0.363
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0111 0.0213 0.1491
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Echinococcus granulosus insulin growth factor 1 receptor beta 0.01 0.0185 0.0869
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0523 0.1295 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0041 0.0199
Echinococcus granulosus Furin 1 0.0251 0.0582 0.2824
Loa Loa (eye worm) TK/EGFR protein kinase 0.0312 0.074 0.363
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Echinococcus multilocularis insulin receptor 0.01 0.0185 0.1062
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0523 0.1295 1
Schistosoma mansoni furin-1 (S08 family) 0.0396 0.0961 0.0948
Giardia lamblia CDC72 0.0181 0.0398 0.3161
Loa Loa (eye worm) guanylate kinase 0.0043 0.0034 0.0166
Loa Loa (eye worm) hypothetical protein 0.0093 0.0165 0.0807
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0025 0.0196
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0521 0.1291 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0019 0.0051
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0111 0.0213 0.155
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0146 0.0304 0.2265
Onchocerca volvulus 0.0093 0.0165 0.671
Plasmodium falciparum plasmepsin VII 0.0093 0.0165 0.0422
Schistosoma mansoni tyrosine kinase 0.0046 0.0041 0.0027
Schistosoma mansoni hypothetical protein 0.014 0.029 0.0276
Echinococcus granulosus palmitoyl protein thioesterase 1 0.0083 0.0139 0.0646
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0476 0.1171 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0582 0.4446
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0014 0.003
Trypanosoma cruzi N-myristoyl transferase, putative 0.0181 0.0398 0.2992
Plasmodium falciparum plasmepsin III 0.0093 0.0165 0.0422
Mycobacterium leprae Possible secreted protease 0.0111 0.0213 0.1536
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Echinococcus multilocularis Furin 1 0.0251 0.0582 0.3451
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0213 0.1554
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0523 0.1295 0.7742
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.014 0.029 0.216
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0025 0.0087
Brugia malayi Subtilase family protein 0.0111 0.0213 0.1043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Echinococcus multilocularis disks large 3 0.0047 0.0045 0.0221
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0025 0.0096
Trichomonas vaginalis N-myristoyl transferase, putative 0.0119 0.0234 0.1721
Echinococcus granulosus epidermal growth factor receptor 0.0168 0.0363 0.1744
Plasmodium falciparum plasmepsin V 0.0093 0.0165 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Echinococcus granulosus insulin receptor 0.01 0.0185 0.0869
Trypanosoma brucei N-myristoyl transferase, putative 0.0181 0.0398 0.3069
Plasmodium vivax subtilisin-like serine protease, putative 0.0111 0.0213 0.0585
Toxoplasma gondii subtilisin SUB5 0.0111 0.0213 0.0169
Plasmodium falciparum subtilisin-like protease 2 0.0111 0.0213 0.0585
Loa Loa (eye worm) aminopeptidase N 0.0036 0.0014 0.007
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0014 0.011
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Echinococcus granulosus disks large 3 0.0047 0.0045 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Brugia malayi aspartic protease BmAsp-2, identical 0.0093 0.0165 0.0807
Echinococcus granulosus tyrosine kinase 0.0037 0.0019 0.0051
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0111 0.0213 0.1643
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.01 0.0185 0.1062
Plasmodium vivax plasmepsin IV, putative 0.0166 0.0356 0.1067
Loa Loa (eye worm) peptidase family M1 containing protein 0.0098 0.0178 0.0871
Toxoplasma gondii subtilisin SUB7 0.0111 0.0213 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Giardia lamblia High cysteine membrane protein Group 2 0.027 0.063 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.0041 0.0199
Loa Loa (eye worm) TK protein kinase 0.0037 0.0019 0.0091
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.014 0.029 0.216
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0014 0.0036
Brugia malayi neuroendocrine convertase 1 precursor 0.0536 0.1331 0.6523
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0269 0.1989
Toxoplasma gondii subtilisin SUB2 0.0111 0.0213 0.0169
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0035 0.0158
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0111 0.0213 0.1716
Schistosoma mansoni cathepsin D (A01 family) 0.0352 0.0845 0.0832
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0111 0.0213 0.1716
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0269 0.2078
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0093 0.0165 0.015
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0111 0.0213 0.1491
Echinococcus multilocularis 0.0666 0.1671 1
Brugia malayi ribonucleotide reductase 2 0.0132 0.0269 0.1319
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0058 0.0075 0.006
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0132 0.0269 0.2078
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0476 0.1171 0.906
Trichomonas vaginalis hypothetical protein 0.014 0.029 0.216
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0045 0.0039 0.03
Toxoplasma gondii subtilisin SUB6 0.0111 0.0213 0.0169
Plasmodium vivax subtilisin-like protease 2, putative 0.0111 0.0213 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Loa Loa (eye worm) reprolysin 0.0045 0.0038 0.0188
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0014 0.003
Plasmodium falciparum plasmepsin IX 0.0093 0.0165 0.0422
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0041 0.0163
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0251 0.0582 0.0568
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0038 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0521 0.1291 0.6315
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Schistosoma mansoni tyrosine kinase 0.0165 0.0355 0.0341
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0045 0.0038 0.0186
Brugia malayi proprotein convertase 2 0.0536 0.1331 0.6523
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0523 0.1295 0.4223
Brugia malayi celfurPC protein 0.0666 0.1671 0.819
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0111 0.0213 0.1536
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0111 0.0213 0.0199
Brugia malayi Palmitoyl-protein thioesterase 1 precursor 0.0083 0.0139 0.0683
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0025 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0025 0.0087
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0181 0.0398 0.1206
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.0041 0.0163
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0111 0.0213 0.1043
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0111 0.0213 0.1536
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0111 0.0213 0.1491
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0132 0.0269 0.1794
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0269 0.1989
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.0041 0.0199
Loa Loa (eye worm) TK/INSR protein kinase 0.01 0.0185 0.0906
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0041 0.0199
Brugia malayi hypothetical protein 0.0036 0.0014 0.007
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.0041 0.0199
Loa Loa (eye worm) TK protein kinase 0.0033 0.0008 0.004
Trichomonas vaginalis conserved hypothetical protein 0.014 0.029 0.216
Brugia malayi N-myristoyltransferase 2 0.0181 0.0398 0.1949
Schistosoma mansoni site-1 peptidase (S08 family) 0.0111 0.0213 0.0199
Plasmodium falciparum subtilisin-like protease 3 0.0111 0.0213 0.0585
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0166 0.0356 0.0673
Loa Loa (eye worm) N-myristoyltransferase 2 0.0181 0.0398 0.1949
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0085 0.0145 0.071
Plasmodium falciparum plasmepsin IV 0.0166 0.0356 0.1067
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0019 0.0062
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.0041 0.0199
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0523 0.1295 0.6335
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0582 0.4446
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0132 0.0269 0.0367
Echinococcus granulosus dna polymerase kappa 0.004 0.0025 0.0085
Brugia malayi hypothetical protein 0.0093 0.0165 0.0807
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0697 0.1753 0.1742
Onchocerca volvulus 0.0121 0.0238 1
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0213 0.1554
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0523 0.1295 0.1283
Leishmania major subtilisin-like serine peptidase 0.0111 0.0213 0.155
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0523 0.1295 0.635
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0019 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0582 0.4446
Brugia malayi Protein kinase domain containing protein 0.01 0.0185 0.0906
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Loa Loa (eye worm) hypothetical protein 0.0111 0.0213 0.1043
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0014 0.0036
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.0041 0.0199
Schistosoma mansoni tyrosine kinase 0.0165 0.0355 0.0341
Toxoplasma gondii subtilisin SUB4 0.0111 0.0213 0.0169
Schistosoma mansoni tyrosine kinase 0.01 0.0185 0.0171
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0111 0.0213 0.1716
Echinococcus multilocularis aminopeptidase N 0.0121 0.0238 0.1384
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0132 0.0269 0.1569
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0041 0.0163
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.0041 0.0163
Trypanosoma cruzi subtilisin peptidase 0.0111 0.0213 0.155
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0025 0.0196
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0181 0.0398 0.1206
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Loa Loa (eye worm) SRC-1 0.0046 0.0041 0.0202
Plasmodium vivax aspartyl protease, putative 0.0093 0.0165 0.0422
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0014 0.003
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0523 0.1295 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.0669 0.3282
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0181 0.0398 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0111 0.0213 0.1491
Schistosoma mansoni memapsin-2 (A01 family) 0.1769 0.4571 0.4563
Loa Loa (eye worm) palmitoyl-protein thioesterase 1 0.0083 0.0139 0.0683
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0523 0.1295 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0025 0.0087
Echinococcus multilocularis 0.0096 0.0174 0.0995
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0045 0.0052
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0093 0.0165 0.0807
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0132 0.0269 0.2078
Toxoplasma gondii aspartyl protease ASP1 0.0166 0.0356 0.0673
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0269 0.0774
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0038 0.0148
Echinococcus granulosus epidermal growth factor receptor 0.0312 0.074 0.3604
Echinococcus multilocularis dna polymerase kappa 0.004 0.0025 0.0103
Echinococcus multilocularis epidermal growth factor receptor 0.0168 0.0363 0.2132
Loa Loa (eye worm) hypothetical protein 0.0045 0.0038 0.0188
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0111 0.0213 0.155
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0132 0.0269 0.1319
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0213 0.1554
Leishmania major N-myristoyl transferase, putative 0.0181 0.0398 0.2992
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0093 0.0165 0.015
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0168 0.0363 0.1744
Brugia malayi Pepsin A precursor 0.0093 0.0165 0.0807
Onchocerca volvulus 0.0093 0.0165 0.671
Echinococcus multilocularis membrane bound transcription factor site 1 0.0111 0.0213 0.123
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0132 0.0269 0.1284
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0269 0.1989
Schistosoma mansoni tyrosine kinase 0.0046 0.0041 0.0027

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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