TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 401.503 | Formula: C21H31N5O3
H donors: 1 H acceptors: 3 LogP: 1.45 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC(C(=O)NCc1nnc2n1CCN(CC2)Cc1cccc(c1OC)OC)C
InChi: 1S/C21H31N5O3/c1-5-15(2)21(27)22-13-19-24-23-18-9-10-25(11-12-26(18)19)14-16-7-6-8-17(28-3)20(16)29-4/h6-8,15H,5,9-14H2,1-4H3,(H,22,27)
InChiKey: SUVDPMBRIAUYAO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Vam6:Vps39 protein	0.0051	0.041	0.041
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0044	0.0044
Brugia malayi	Delta serrate ligand family protein	0.0009	0.0029	0.0138
Trichomonas vaginalis	AAA ATPase, putative	0.0007	0.0017	0.0049
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0044	0.0044
Echinococcus multilocularis	vacuolar protein sorting associated protein 4A	0.0007	0.0017	0.0017
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.1117	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0044	0.0044
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0012	0.006	0.0408
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0044	0.0159
Echinococcus multilocularis	Diacylglycerol kinase zeta	0.0012	0.006	0.006
Brugia malayi	EGF-like domain containing protein	0.0009	0.0029	0.0138
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0163	0.1417	0.6788
Echinococcus granulosus	RUN	0.0197	0.1727	0.1727
Echinococcus granulosus	cpg binding protein	0.0031	0.0229	0.0229
Entamoeba histolytica	hypothetical protein, conserved	0.0311	0.2744	1
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0214	0.1023
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0016	0.0016
Brugia malayi	EGF-like domain containing protein	0.0009	0.0029	0.0138
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0141	0.122	0.122
Plasmodium vivax	multidomain scavenger receptor, putative	0.0197	0.1727	0.3025
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0191	0.0698
Brugia malayi	steroid hormone receptor	0.001	0.0044	0.0209
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0163	0.1417	0.8177
Plasmodium vivax	cell division cycle ATPase, putative	0.0051	0.0411	0.0636
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0044	0.0209
Onchocerca volvulus	Peroxidase homolog	0.0027	0.0191	0.0958
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1502	0.5473
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0044	0.0209
Mycobacterium ulcerans	ATPase	0.0084	0.0711	0.2424
Entamoeba histolytica	diacylglycerol kinase, putative	0.0012	0.006	0.0159
Brugia malayi	valosin containing protein	0.0083	0.0695	0.333
Entamoeba histolytica	diacylglycerol kinase, putative	0.0012	0.006	0.0159
Echinococcus granulosus	lipoxygenase domain containing protein	0.0197	0.1727	0.1727
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0044	0.0159
Loa Loa (eye worm)	ceramide kinase	0.0012	0.006	0.0219
Onchocerca volvulus		0.0027	0.0191	0.0958
Leishmania major	sphingosine kinase A, B, putative	0.0012	0.006	0.0382
Echinococcus multilocularis	GTPase activating Rap:RanGAP domain 3	0.0051	0.041	0.041
Brugia malayi	ecdysteroid receptor	0.001	0.0044	0.0209
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0012	0.006	0.0408
Schistosoma mansoni	diacylglycerol kinase zeta iota	0.0012	0.006	0.006
Echinococcus granulosus	katanin p60 ATPase containing subunit A1	0.0007	0.0017	0.0017
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0044	0.0087
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0032	0.0032
Schistosoma mansoni	laminin gamma-3 chain	0.0009	0.0029	0.0029
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0238	0.2088	0.7609
Schistosoma mansoni	notch	0.0009	0.0029	0.0029
Trypanosoma cruzi	katanin, putative	0.0007	0.0017	0.0000043848
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0044	0.0044
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0184	0.1607	0.1607
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Trypanosoma cruzi	katanin-like protein, putative	0.0007	0.0017	0.0000043848
Brugia malayi	hypothetical protein	0.0197	0.1727	0.827
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0044	0.0209
Brugia malayi	Temporarily assigned gene name protein 59	0.0051	0.041	0.1962
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0044	0.0044
Trypanosoma cruzi	Diacylglycerol kinase catalytic domain containing protein, putative	0.0012	0.006	0.0382
Echinococcus granulosus	protein kinase	0.0123	0.1057	0.1057
Onchocerca volvulus	Dual oxidase homolog	0.0027	0.0191	0.0958
Schistosoma mansoni	hypothetical protein	0.0007	0.0017	0.0017
Echinococcus granulosus	protein jagged 2	0.0009	0.0029	0.0029
Schistosoma mansoni	cpg binding protein	0.0031	0.0229	0.0229
Schistosoma mansoni	microtubule-associated protein tau	0.0701	0.6257	0.6257
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0191	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Schistosoma mansoni	serine/threonine protein kinase	0.0163	0.1417	0.1417
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0044	0.0044
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0044	0.0044
Trichomonas vaginalis	bmru protein, putative	0.0012	0.006	0.0408
Giardia lamblia	AAA family ATPase	0.0084	0.0711	1
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0184	0.1607	0.1607
Schistosoma mansoni	cpg binding protein	0.0029	0.0214	0.0214
Schistosoma mansoni	peroxidasin	0.0027	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Brugia malayi	Ceramide kinase	0.0012	0.006	0.0287
Echinococcus granulosus	Polycystic kidney disease protein	0.0197	0.1727	0.1727
Schistosoma mansoni	coup transcription factor	0.001	0.0044	0.0044
Trichomonas vaginalis	sphingosine kinase, putative	0.0012	0.006	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0044	0.0159
Brugia malayi	Peroxidasin	0.0027	0.0191	0.0917
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0163	0.1417	0.5165
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0163	0.1417	0.1417
Echinococcus multilocularis	cpg binding protein	0.0031	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0159
Brugia malayi	nuclear receptor NHR-88	0.001	0.0044	0.0209
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0625	0.5571	1
Giardia lamblia	High cysteine protein	0.0009	0.0029	0.0177
Loa Loa (eye worm)	fidgetin protein	0.0007	0.0017	0.006
Schistosoma mansoni	lipoxygenase	0.0762	0.6804	0.6804
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0044	0.0209
Brugia malayi	ATPase, AAA family protein	0.0007	0.0017	0.0079
Trichomonas vaginalis	AAA ATPase, putative	0.0007	0.0017	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Onchocerca volvulus		0.0012	0.006	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Schistosoma mansoni	septate junction protein	0.0009	0.0029	0.0029
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0051	0.041	0.3455
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0053	0.0424	0.0424
Brugia malayi	vps4b-prov protein	0.0007	0.0017	0.0079
Schistosoma mansoni	notch	0.0009	0.0029	0.0029
Brugia malayi	Calcium binding EGF domain containing protein	0.0009	0.0029	0.0138
Entamoeba histolytica	transitional endoplasmic reticulum ATPase, putative	0.0134	0.1155	0.4173
Echinococcus multilocularis	slit 2 protein	0.0009	0.0029	0.0029
Onchocerca volvulus	Peroxidasin homolog	0.0027	0.0191	0.0958
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0159
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0044	0.0087
Schistosoma mansoni	peroxidasin	0.0027	0.0191	0.0191
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0044	0.0044
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0044	0.0044
Schistosoma mansoni	diacylglycerol kinase theta	0.0012	0.006	0.006
Echinococcus granulosus	neurogenic locus notch protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	vps4b-prov protein	0.0007	0.0017	0.006
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0123	0.1057	0.3853
Schistosoma mansoni	diacylglycerol kinase theta	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0051	0.041	0.1493
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0051	0.041	0.1493
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0508	0.0508
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0197	0.1727	0.1727
Echinococcus granulosus	neurogenic locus protein delta	0.0009	0.0029	0.0029
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0053	0.0424	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Loa Loa (eye worm)	blistered cuticle protein 3	0.0027	0.0191	0.0698
Echinococcus multilocularis	neurogenic locus protein delta	0.0009	0.0029	0.0029
Echinococcus multilocularis	neurogenic locus notch protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0163	0.1417	0.1417
Loa Loa (eye worm)	vesicle-fusing ATPase	0.0083	0.0695	0.2534
Echinococcus granulosus	fidgetin protein 1	0.0007	0.0017	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0184	0.1607	0.1607
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0009	0.0029	0.0029
Entamoeba histolytica	diacylglycerol kinase, putative	0.0012	0.006	0.0159
Toxoplasma gondii	diacylglycerol kinase, putative	0.0012	0.006	0.0361
Brugia malayi	Doublecortin family protein	0.0197	0.1727	0.827
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0012	0.006	0.0382
Schistosoma mansoni	hypothetical protein	0.0197	0.1727	0.1727
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0044	0.0044
Trypanosoma brucei	Sphingosine kinase	0.0012	0.006	0.0382
Entamoeba histolytica	cdc48-like protein, putative	0.0134	0.1155	0.4173
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Brugia malayi	transitional endoplasmic reticulum ATPase TER94, putative	0.0058	0.0476	0.2279
Echinococcus granulosus	acylglycerol kinase mitochondrial	0.0012	0.006	0.006
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0012	0.006	0.0382
Schistosoma mansoni	hypothetical protein	0.0051	0.041	0.041
Brugia malayi	Blistered cuticle protein 3	0.0027	0.0191	0.0917
Plasmodium vivax	cell division cycle protein 48 homologue, putative	0.0134	0.1155	0.1987
Echinococcus granulosus	fibropellin Ia	0.0009	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.0012	0.006	0.0382
Echinococcus granulosus	dnaJ subfamily B	0.0416	0.3689	0.3689
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0009	0.0029	0.0029
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0032	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.0219
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0058	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Brugia malayi	diacylglycerol kinase	0.0012	0.006	0.0287
Onchocerca volvulus		0.0197	0.1727	1
Schistosoma mansoni	rab6-interacting	0.0197	0.1727	0.1727
Leishmania major	diacylglycerol kinase, putative	0.0012	0.006	0.0382
Schistosoma mansoni	notch	0.0009	0.0029	0.0029
Echinococcus multilocularis	RUN	0.0197	0.1727	0.1727
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0044	0.0044
Brugia malayi	hypothetical protein	0.0012	0.006	0.0287
Echinococcus granulosus	Diacylglycerol kinase zeta	0.0012	0.006	0.006
Schistosoma mansoni	rab6-interacting	0.0197	0.1727	0.1727
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0044	0.0209
Echinococcus granulosus	Diacylglycerol kinase theta	0.0012	0.006	0.006
Onchocerca volvulus		0.0027	0.0191	0.0958
Toxoplasma gondii	EGF family domain-containing protein	0.0009	0.0029	0.0102
Echinococcus granulosus	peroxidasin	0.0027	0.0191	0.0191
Brugia malayi	Cadherin domain containing protein	0.0009	0.0029	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0197	0.1727	0.6293
Onchocerca volvulus		0.0027	0.0191	0.0958
Schistosoma mansoni	vam6/vps39 related	0.0051	0.041	0.041
Brugia malayi	Diacylglycerol kinase protein 2	0.0012	0.006	0.0287
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0159
Echinococcus granulosus	protein jagged 2	0.0009	0.0029	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0044	0.0159
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0051	0.041	0.041
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0044	0.0209
Trichomonas vaginalis	diacylglycerol kinase, epsilon, putative	0.0012	0.006	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0012	0.006	0.0382
Loa Loa (eye worm)	ATPase	0.0007	0.0017	0.006
Echinococcus granulosus	protein jagged 1	0.0009	0.0029	0.0029
Mycobacterium ulcerans	hypothetical protein	0.0311	0.2744	1
Plasmodium falciparum	cell division cycle protein 48 homologue, putative	0.0134	0.1155	0.6655
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0044	0.0209
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0044	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0044	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Trichomonas vaginalis	proteasome-activating nucleotidase, putative	0.0033	0.0251	0.1989
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.0219
Echinococcus multilocularis	protein jagged 1	0.0009	0.0029	0.0029
Brugia malayi	EGF-like domain containing protein	0.0009	0.0029	0.0138
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0044	0.0159
Schistosoma mansoni	notch	0.0009	0.0029	0.0029
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0134	0.1155	0.1155
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.0172	0.1502	0.1502
Schistosoma mansoni	hypothetical protein	0.0012	0.006	0.006
Trypanosoma cruzi	katanin, putative	0.0007	0.0017	0.0000043848
Onchocerca volvulus	Transitional endoplasmic reticulum ATPase homolog	0.0141	0.122	0.7016
Toxoplasma gondii	transitional endoplasmic reticulum ATPase, putative	0.0084	0.0711	0.5767
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0159
Echinococcus multilocularis	microtubule associated protein 2	0.0701	0.6257	0.6257
Brugia malayi	Cadherin domain containing protein	0.0009	0.0029	0.0138
Schistosoma mansoni	protein kinase	0.0123	0.1057	0.1057
Leishmania major	diacylglycerol kinase-like protein	0.0012	0.006	0.0382
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0012	0.006	0.0408
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0163	0.1417	0.5165
Mycobacterium tuberculosis	Putative conserved ATPase	0.0084	0.0711	0.2424
Echinococcus multilocularis	protein jagged 1	0.0009	0.0029	0.0029
Trypanosoma cruzi	Sphingosine kinase	0.0012	0.006	0.0382
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0044	0.0209
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0053	0.0424	0.0424
Brugia malayi	notch-like transmembrane receptor	0.0009	0.0029	0.0138
Loa Loa (eye worm)	notch protein	0.0009	0.0029	0.0105
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0044	0.0209
Entamoeba histolytica	diacylglycerol kinase, putative	0.0012	0.006	0.0159
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0044	0.0209
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0051	0.041	0.041
Trichomonas vaginalis	skd/vacuolar sorting, putative	0.0007	0.0017	0.0049
Schistosoma mansoni	cpg binding protein	0.0031	0.0229	0.0229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0044	0.0159
Loa Loa (eye worm)	eye-specific diacylglycerol kinase	0.0012	0.006	0.0219
Brugia malayi	SAP1 protein	0.0007	0.0017	0.0079
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0044	0.0044
Brugia malayi	vesicle-fusing ATPase	0.0083	0.0695	0.333
Schistosoma mansoni	polycystin 1-related	0.0197	0.1727	0.1727
Brugia malayi	hypothetical protein	0.0051	0.041	0.1962
Echinococcus granulosus	neurogenic locus notch protein	0.0009	0.0029	0.0029
Schistosoma mansoni	sphingosine kinase A B	0.0311	0.2744	0.2744
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0044	0.0044
Trichomonas vaginalis	bmru protein, putative	0.0012	0.006	0.0408
Brugia malayi	hypothetical protein	0.0197	0.1727	0.827
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0044	0.0209
Onchocerca volvulus		0.0029	0.0214	0.1088
Plasmodium falciparum	diacylglycerol kinase, putative	0.0012	0.006	0.0254
Schistosoma mansoni	loxhd1	0.0197	0.1727	0.1727
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0012	0.006	0.006
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0012	0.006	0.0408
Brugia malayi	map kinase activated protein kinase protein 2	0.0184	0.1607	0.7693
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0012	0.006	0.006
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0051	0.041	0.3455
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0053	0.0424	0.1544
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0448	0.3588
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0197	0.1727	0.1727
Brugia malayi	GCC2 and GCC3 family protein	0.0009	0.0029	0.0138
Loa Loa (eye worm)	Notch2	0.0009	0.0029	0.0105
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0424	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0159
Echinococcus granulosus	neurogenic locus notch protein 4	0.0009	0.0029	0.0029
Trypanosoma brucei	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0051	0.041	0.3455
Brugia malayi	Calcium binding EGF domain containing protein	0.0009	0.0029	0.0138
Trypanosoma cruzi	vesicular transport protein (CDC48 homologue), putative	0.0007	0.0017	0.0000043848
Echinococcus granulosus	microtubule associated protein 2	0.0701	0.6257	0.6257
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Brugia malayi	Protein kinase domain containing protein	0.0163	0.1417	0.6788
Mycobacterium tuberculosis	Conserved protein	0.0311	0.2744	1
Trypanosoma cruzi	vacuolar protein sorting-associated protein 4, putative	0.0007	0.0017	0.0000043848
Echinococcus multilocularis	peroxidasin	0.0027	0.0191	0.0191
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0191	0.0698
Toxoplasma gondii	diacylglycerol kinase catalytic domain-containing protein	0.0012	0.006	0.0361
Leishmania major	hypothetical protein, conserved	0.0012	0.006	0.0382
Schistosoma mansoni	cell polarity protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	katanin p60 ATPase containing subunit A1	0.0007	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Onchocerca volvulus		0.0051	0.041	0.2244
Echinococcus multilocularis	protein jagged 2	0.0009	0.0029	0.0029
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0191	0.0917
Echinococcus granulosus	vacuolar protein sorting associated protein 4A	0.0007	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Trypanosoma cruzi	Valosin-containing protein, putative	0.0134	0.1155	1
Loa Loa (eye worm)	hypothetical protein	0.0197	0.1727	0.6293
Plasmodium falciparum	LCCL domain-containing protein	0.0197	0.1727	1
Schistosoma mansoni	protein kinase	0.0053	0.0424	0.0424
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0009	0.0029	0.0138
Brugia malayi	EGF-like domain containing protein	0.0009	0.0029	0.0138
Echinococcus multilocularis	ceramide kinase	0.0012	0.006	0.006
Loa Loa (eye worm)	VCP protein	0.0058	0.0476	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0191	0.0698
Echinococcus multilocularis	Polycystic kidney disease protein	0.0197	0.1727	0.1727
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0141	0.122	0.122
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0016	0.0016
Onchocerca volvulus		0.0197	0.1727	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0032	0.0032
Onchocerca volvulus		0.001	0.0044	0.0087
Onchocerca volvulus	Ceramide kinase 1 homolog	0.0012	0.006	0.0184
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0424	0.0424
Leishmania major	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	0.0134	0.1155	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0044	0.0087
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0424	0.203
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0044	0.0044
Trichomonas vaginalis	sphingosine kinase, putative	0.0012	0.006	0.0408
Echinococcus granulosus	GTPase activating Rap:RanGAP domain 3	0.0051	0.041	0.041
Trichomonas vaginalis	skd/vacuolar sorting, putative	0.0007	0.0017	0.0049
Echinococcus granulosus	protein jagged 1	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Trypanosoma brucei	Valosin-containing protein	0.0134	0.1155	1
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0044	0.0044
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0044	0.0044
Echinococcus granulosus	slit 2 protein	0.0009	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0044	0.0044
Trypanosoma cruzi	metalloprotease, putative	0.0007	0.0017	0.0000043848
Schistosoma mansoni	notch	0.0009	0.0029	0.0029
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0191	0.0917
Brugia malayi	probable protein kinase	0.0174	0.1516	0.726
Onchocerca volvulus	Chorion peroxidase homolog	0.0027	0.0191	0.0958
Trichomonas vaginalis	spermatogenesis associated factor, putative	0.0141	0.122	1
Brugia malayi	nuclear hormone receptor	0.001	0.0044	0.0209
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0214	0.0778
Brugia malayi	EGF-like domain containing protein	0.0009	0.0029	0.0138
Schistosoma mansoni	lipoxygenase	0.1117	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0044	0.0044
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0044	0.0209
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0191	0.0698
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0053	0.0424	0.0424
Echinococcus multilocularis	neural cadherin	0.0009	0.0029	0.0029
Schistosoma mansoni	skd/vacuolar sorting	0.0007	0.0017	0.0017
Echinococcus multilocularis	sphingosine kinase 1	0.0311	0.2744	0.2744
Echinococcus granulosus	transitional endoplasmic reticulum atpase	0.0141	0.122	0.122
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0044	0.0209
Onchocerca volvulus	Peroxidasin homolog	0.0027	0.0191	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0044	0.0044
Plasmodium falciparum	diacylglycerol kinase, putative	0.0012	0.006	0.0254
Brugia malayi	fidgetin protein	0.0007	0.0017	0.0079
Echinococcus multilocularis	fidgetin protein 1	0.0007	0.0017	0.0017
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0191	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0044	0.0044
Trypanosoma brucei	diacylglycerol kinase, putative	0.0012	0.006	0.0382
Trypanosoma cruzi	katanin, putative	0.0007	0.0017	0.0000043848
Schistosoma mansoni	rap gtpase-activating protein	0.0051	0.041	0.041
Schistosoma mansoni	slit	0.0009	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.006	0.0408
Loa Loa (eye worm)	diacylglycerol kinase 2	0.0012	0.006	0.0219
Echinococcus multilocularis	notch	0.0009	0.0029	0.0029
Trypanosoma brucei	Diacylglycerol kinase catalytic domain containing protein, putative	0.0012	0.006	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0044	0.0044
Echinococcus multilocularis	fibropellin Ia	0.0009	0.0029	0.0029
Toxoplasma gondii	cell division protein CDC48CY	0.0141	0.122	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0009	0.0029	0.0029
Toxoplasma gondii	diacylglycerol kinase accessory domain (presumed) domain-containing protein	0.0012	0.006	0.0361
Brugia malayi	diacylglycerol kinase	0.0012	0.006	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.0219
Toxoplasma gondii	cell division protein CDC48AP	0.0084	0.0711	0.5767
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Schistosoma mansoni	hypothetical protein	0.0416	0.3689	0.3689
Brugia malayi	hypothetical protein	0.0027	0.0191	0.0917
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0044	0.0044
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0044	0.0044
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0053	0.0424	0.0424
Trypanosoma cruzi	vacuolar transport protein 4A, putative	0.0007	0.0017	0.0000043848
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus granulosus	notch	0.0009	0.0029	0.0029
Echinococcus multilocularis	dnaJ subfamily B	0.0416	0.3689	0.3689
Brugia malayi	Calcium binding EGF domain containing protein	0.0009	0.0029	0.0138
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0029
Trypanosoma cruzi	Sphingosine kinase	0.0012	0.006	0.0382
Brugia malayi	Muscle positioning protein 4	0.0009	0.0029	0.0138
Echinococcus multilocularis	neurogenic locus notch protein	0.0009	0.0029	0.0029
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0031	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0044	0.0209
Echinococcus granulosus	ceramide kinase	0.0012	0.006	0.006
Echinococcus granulosus	neural cadherin	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0051	0.041	0.1493
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Trichomonas vaginalis	26S protease regulatory subunit S10b, putative	0.0033	0.0251	0.1989
Echinococcus granulosus	sphingosine kinase 1	0.0311	0.2744	0.2744
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0044	0.0044
Brugia malayi	EGF-like domain containing protein	0.0009	0.0029	0.0138
Loa Loa (eye worm)	doublecortin family protein	0.0197	0.1727	0.6293
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	acylglycerol kinase, mitochondrial	0.0012	0.006	0.006
Schistosoma mansoni	sphingoid long chain base kinase	0.0311	0.2744	0.2744
Trypanosoma brucei	hypothetical protein, conserved	0.0012	0.006	0.0382
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0012	0.006	0.0382
Trypanosoma cruzi	katanin, putative	0.0007	0.0017	0.0000043848
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0695	0.2534
Trichomonas vaginalis	spastin, putative	0.0007	0.0017	0.0049
Echinococcus granulosus	delta-like protein 1	0.0009	0.0029	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0044	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0044	0.0209
Echinococcus granulosus	lipoxygenase domain containing protein	0.0197	0.1727	0.1727
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0184	0.1607	0.5854
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0009	0.0029	0.0029
Brugia malayi	EGF-like domain containing protein	0.0009	0.0029	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0191	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0311	0.2744	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0191	0.0698
Schistosoma mansoni	protein kinase	0.0174	0.1516	0.1516
Onchocerca volvulus	Peroxidase homolog	0.0027	0.0191	0.0958
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0058	0.0476	0.0476
Echinococcus multilocularis		0.0123	0.1057	0.1057
Brugia malayi	Eye-specific diacylglycerol kinase	0.0012	0.006	0.0287
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0053	0.0424	0.0424
Schistosoma mansoni	notch	0.0009	0.0029	0.0029
Trypanosoma cruzi	katanin, putative	0.0007	0.0017	0.0000043848
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.006	0.0382
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0105
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0016	0.0016
Brugia malayi	follicle stimulating hormone receptor	0.0238	0.2088	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 817771