TDR Targets

Basic information

Technical information

TDR Targets ID: 840160
Name: ethyl 4-(4-ethoxyphenyl)-2-oxo-6-(phenylsulfo nylmethyl)-3,4-dihydro-1H-pyrimidine-5-carbox ylate
MW: 444.501 | Formula: C22H24N2O6S
H donors: 2 H acceptors: 4 LogP: 2.08 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(NC(=O)NC1c1ccc(cc1)OCC)CS(=O)(=O)c1ccccc1
InChi: 1S/C22H24N2O6S/c1-3-29-16-12-10-15(11-13-16)20-19(21(25)30-4-2)18(23-22(26)24-20)14-31(27,28)17-8-6-5-7-9-17/h5-13,20H,3-4,14H2,1-2H3,(H2,23,24,26)
InChiKey: KVCNAGMPDZBJBN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(4-ethoxyphenyl)-2-oxo-6-(phenylsulfonylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
4-(4-ethoxyphenyl)-2-keto-6-(phenylsulfonylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.0514	0.3532
Trichomonas vaginalis	importin beta-1, putative	0.0042	0.0139	0.0237
Toxoplasma gondii	aldehyde dehydrogenase	0.0109	0.0573	1
Mycobacterium leprae	Probable lipase LipE	0.01	0.0511	0.9697
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0038	0.0111	0.0189
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.01	0.0511	0.1094
Leishmania major	hypothetical protein, conserved	0.0047	0.017	0.0568
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0051	0.0197	0.0357
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0038	0.0111	0.0189
Echinococcus granulosus	survival motor neuron protein 1	0.0213	0.1247	0.2262
Brugia malayi	hypothetical protein	0.0116	0.0617	0.1058
Schistosoma mansoni	hypothetical protein	0.0162	0.0921	0.246
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0051	0.0197	0.0357
Loa Loa (eye worm)	glutathione reductase	0.004	0.0123	0.0158
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0221	0.1305	0.3483
Brugia malayi	diacylglycerol acyltransferase	0.0051	0.0197	0.0292
Onchocerca volvulus		0.01	0.0511	0.3912
Leishmania major	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Mycobacterium ulcerans	hypothetical protein	0.01	0.0511	0.6033
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0051	0.0197	0.0197
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0051	0.0197	0.0197
Toxoplasma gondii	exonuclease III APE	0.0056	0.0227	0.3544
Entamoeba histolytica	hypothetical protein	0.0162	0.0921	1
Echinococcus multilocularis	sterol O acyltransferase 1	0.0051	0.0197	0.0197
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0559	0.3504	0.6331
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0636	0.401	1
Entamoeba histolytica	hypothetical protein	0.0051	0.0197	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0052	0.0027
Plasmodium falciparum	importin beta, putative	0.0052	0.0203	0.8264
Trypanosoma brucei	cytochrome P450, putative	0.0049	0.0181	0.0642
Echinococcus multilocularis	microtubule associated protein 2	0.0589	0.3699	0.3699
Echinococcus multilocularis	beta LACTamase domain containing family member	0.01	0.0511	0.0511
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0027	0.0037	0.0099
Plasmodium vivax	glutathione reductase, putative	0.004	0.0123	0.1823
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.01	0.0514	0.2788
Trypanosoma brucei	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0027	0.0037	0.0099
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0056	0.0227	0.2039
Trypanosoma cruzi	hypothetical protein, conserved	0.01	0.0511	0.2773
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0617	0.1058
Mycobacterium ulcerans	lipase LipD	0.01	0.0511	0.6033
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0039	0.0113	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0213	0.1247	0.221
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.01	0.0514	0.5091
Trypanosoma cruzi	hypothetical protein, conserved	0.01	0.0511	0.2773
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0027	0.0037	0.0099
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0109	0.0573	0.1039
Leishmania major	importin beta-1 subunit, putative	0.0042	0.0139	0.0369
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0056	0.0227	0.0937
Leishmania major	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Entamoeba histolytica	vacuolar protein sorting 26	0.0051	0.0197	0.1274
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.0123	0.027
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.01	0.0514	0.0514
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0197	0.0747
Leishmania major	GTP-binding protein, putative	0.0039	0.0113	0.0204
Leishmania major	trypanothione reductase	0.004	0.0123	0.027
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0109	0.0573	0.6897
Loa Loa (eye worm)	hypothetical protein	0.01	0.0511	0.0866
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0102	0.0525	0.1128
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0051	0.0197	0.0525
Mycobacterium ulcerans	esterase/lipase LipP	0.01	0.0511	0.6033
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0038	0.0112	0.1576
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0197	0.0292
Loa Loa (eye worm)	hypothetical protein	0.01	0.0511	0.0866
Loa Loa (eye worm)	cytochrome P450	0.0034	0.0082	0.0082
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0051	0.0197	0.0525
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0106	0.0553	0.1003
Entamoeba histolytica	hypothetical protein	0.0162	0.0921	1
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0051	0.0197	0.0197
Schistosoma mansoni	lipoxygenase	0.0106	0.0553	0.1476
Brugia malayi	cytochrome P450	0.0034	0.0082	0.0082
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0109	0.0573	0.125
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0221	0.1305	0.1305
Brugia malayi	beta-lactamase family protein	0.01	0.0511	0.0866
Mycobacterium tuberculosis	Conserved protein	0.01	0.0511	0.1094
Trypanosoma brucei	hypothetical protein, conserved	0.01	0.0511	0.2773
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0038	0.0112	0.1395
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0042	0.0139	0.0369
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.01	0.0511	0.1365
Brugia malayi	Cytochrome P450 family protein	0.0034	0.0082	0.0082
Schistosoma mansoni	hypothetical protein	0.0029	0.0052	0.0138
Schistosoma mansoni	importin beta-1	0.0052	0.0203	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0347	0.0566
Toxoplasma gondii	hypothetical protein	0.0051	0.0197	0.2982
Plasmodium falciparum	glutathione reductase	0.004	0.0123	0.2392
Brugia malayi	latrophilin 2 splice variant baaae	0.0029	0.0052	0.0027
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0051	0.0197	0.1274
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0221	0.1305	0.2314
Brugia malayi	Hhat protein	0.0051	0.0197	0.0292
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0109	0.0573	0.317
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0102	0.0525	0.1128
Trichomonas vaginalis	penicillin-binding protein, putative	0.01	0.0511	0.3512
Trichomonas vaginalis	D-aminoacylase, putative	0.01	0.0511	0.3512
Onchocerca volvulus		0.01	0.0511	0.3912
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0056	0.0227	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0139	0.0187
Brugia malayi	Thioredoxin reductase	0.004	0.0123	0.0158
Loa Loa (eye worm)	MBOAT family protein	0.0051	0.0197	0.0292
Trypanosoma cruzi	PAB1-binding protein , putative	0.0047	0.017	0.0568
Leishmania major	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0181	0.0263
Plasmodium falciparum	ataxin-2 like protein, putative	0.0047	0.017	0.579
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0051	0.0197	0.0525
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0051	0.0197	0.0525
Echinococcus granulosus	importin subunit beta 1	0.0052	0.0203	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0203	0.0304
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0051	0.0197	0.2982
Schistosoma mansoni	cytochrome P450	0.0034	0.0082	0.0218
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0039	0.0113	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0347	0.0566
Schistosoma mansoni	hypothetical protein	0.0559	0.3504	0.9357
Echinococcus multilocularis	ubiquitin specific protease 41	0.01	0.0514	0.0514
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0043	0.0145	0.0197
Toxoplasma gondii	hypothetical protein	0.0044	0.0147	0.2061
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0034	0.0082	0.0833
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0051	0.0197	0.3368
Brugia malayi	MBOAT family protein	0.0596	0.3745	0.6771
Mycobacterium tuberculosis	Probable esterase LipL	0.01	0.0511	0.1094
Trypanosoma cruzi	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Onchocerca volvulus		0.0051	0.0197	0.1318
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0049	0.0181	0.1398
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.004	0.0123	0.0106
Brugia malayi	Muscleblind-like protein	0.0867	0.5514	1
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0596	0.3745	0.3745
Leishmania major	hypothetical protein, conserved	0.0051	0.0197	0.0743
Leishmania major	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Echinococcus granulosus	muscleblind protein	0.0867	0.5514	1
Brugia malayi	acetyltransferase, GNAT family protein	0.013	0.0711	0.1231
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0271	0.1631	1
Trichomonas vaginalis	set domain proteins, putative	0.0213	0.125	1
Loa Loa (eye worm)	hypothetical protein	0.0867	0.5514	1
Entamoeba histolytica	Ran family GTPase	0.0039	0.0113	0.0268
Schistosoma mansoni	hypothetical protein	0.0165	0.0939	0.2508
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0091	0.0458	0.0959
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0221	0.1305	0.1305
Trypanosoma cruzi	GUP1, putative	0.0051	0.0197	0.0743
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0038	0.0112	0.1395
Brugia malayi	hypothetical protein	0.0213	0.1247	0.221
Echinococcus granulosus	geminin	0.0165	0.0939	0.1704
Echinococcus multilocularis	muscleblind protein	0.0867	0.5514	0.5514
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0102	0.0525	1
Echinococcus granulosus	ubiquitin specific protease 41	0.01	0.0514	0.0931
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0056	0.0227	1
Schistosoma mansoni	ran	0.0039	0.0113	0.0302
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0221	0.1305	0.2314
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0056	0.0227	0.1637
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.0123	0.0158
Leishmania major	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0221	0.1305	0.3483
Brugia malayi	MBOAT family protein	0.0051	0.0197	0.0292
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.01	0.0514	1
Brugia malayi	hypothetical protein	0.0047	0.017	0.0242
Trypanosoma cruzi	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0197	0.0292
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.013	0.0711	0.1898
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.013	0.0711	0.0711
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0143	0.0794	0.1813
Loa Loa (eye worm)	hypothetical protein	0.01	0.0511	0.0866
Schistosoma mansoni	sterol O-acyltransferase 1	0.0051	0.0197	0.0525
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.01	0.0514	0.0514
Plasmodium falciparum	ataxin-2 like protein, putative	0.0047	0.017	0.579
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0039	0.0113	0.0204
Echinococcus multilocularis	muscleblind protein 1	0.0867	0.5514	0.5514
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0051	0.0197	0.0525
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0128	0.0699	0.3986
Entamoeba histolytica	hypothetical protein	0.0042	0.0139	0.0576
Onchocerca volvulus		0.0213	0.125	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.01	0.0514	0.0931
Loa Loa (eye worm)	hhat protein	0.0051	0.0197	0.0292
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0187	0.1081	0.1907
Echinococcus multilocularis	zinc finger protein	0.0544	0.3411	0.3411
Mycobacterium ulcerans	hypothetical protein	0.0143	0.0794	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0181	0.0263
Loa Loa (eye worm)	MBOAT family protein	0.0051	0.0197	0.0292
Mycobacterium tuberculosis	Probable hydrolase	0.01	0.0511	0.1094
Echinococcus granulosus	snurportin 1	0.0559	0.3504	0.6355
Echinococcus multilocularis	geminin	0.0165	0.0939	0.0939
Brugia malayi	hypothetical protein	0.0074	0.0347	0.0566
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0051	0.0197	0.0357
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0128	0.0699	0.3986
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0038	0.0111	0.0189
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0091	0.0458	0.0959
Brugia malayi	beta-lactamase	0.01	0.0511	0.0866
Brugia malayi	Importin beta-1 subunit	0.0052	0.0203	0.0304
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0027	0.0037	0.0037
Onchocerca volvulus	Huntingtin homolog	0.0116	0.0617	0.478
Trypanosoma brucei	importin beta-1 subunit, putative	0.0052	0.0203	0.0785
Entamoeba histolytica	hypothetical protein	0.0162	0.0921	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0051	0.0197	0.0197
Schistosoma mansoni	aldehyde dehydrogenase	0.0109	0.0573	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0197	0.0292
Trichomonas vaginalis	porcupine, putative	0.0051	0.0197	0.0747
Mycobacterium leprae	conserved hypothetical protein	0.01	0.0511	0.9697
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.01	0.0511	0.0866
Schistosoma mansoni	ran	0.0039	0.0113	0.0302
Echinococcus granulosus	beta LACTamase domain containing family member	0.01	0.0511	0.0927
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0051	0.0197	0.0525
Echinococcus granulosus	sterol O acyltransferase 1	0.0051	0.0197	0.0357
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.01	0.0514	0.2788
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0039	0.0113	0.1607
Loa Loa (eye worm)	beta-lactamase	0.01	0.0511	0.0866
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0051	0.0197	0.0197
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0221	0.1305	0.2366
Echinococcus granulosus	thioredoxin glutathione reductase	0.004	0.0123	0.0224
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0056	0.0227	0.0411
Mycobacterium tuberculosis	Probable lipase LipE	0.01	0.0511	0.1094
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0162	0.0921	0.1671
Brugia malayi	MBOAT family protein	0.0051	0.0197	0.0292
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0056	0.0227	0.3216
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0617	0.1058
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0039	0.0113	0.0139
Entamoeba histolytica	hypothetical protein	0.0162	0.0921	1
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0051	0.0197	0.0292
Mycobacterium tuberculosis	Conserved protein	0.01	0.0511	0.1094
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0109	0.0573	0.0573
Brugia malayi	MBOAT family protein	0.0051	0.0197	0.0292
Brugia malayi	beta-lactamase family protein	0.01	0.0511	0.0866
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0039	0.0113	0.0205
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0051	0.0197	0.2982
Mycobacterium tuberculosis	Probable reductase	0.0091	0.0458	0.0959
Trichomonas vaginalis	ap endonuclease, putative	0.0056	0.0227	0.1012
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0039	0.0113	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0197	0.0747
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0056	0.0227	0.0937
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0056	0.0227	0.4003
Brugia malayi	RNA, U transporter 1	0.0149	0.0832	0.1452
Trypanosoma cruzi	PAB1-binding protein , putative	0.0047	0.017	0.0568
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0043	0.0139	0.0187
Brugia malayi	MBOAT family protein	0.0051	0.0197	0.0292
Echinococcus granulosus	cytochrome P450 2K1	0.0034	0.0082	0.0148
Schistosoma mansoni	hypothetical protein	0.0043	0.0145	0.0386
Onchocerca volvulus		0.01	0.0511	0.3912
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0056	0.0227	0.0937
Brugia malayi	Cytochrome P450 family protein	0.0133	0.0726	0.1258
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0051	0.0197	0.7783
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0039	0.0113	0.1638
Trypanosoma brucei	trypanothione reductase	0.004	0.0123	0.027
Toxoplasma gondii	HEAT repeat-containing protein	0.0052	0.0203	0.3104
Trichomonas vaginalis	ap endonuclease, putative	0.0056	0.0227	0.1012
Schistosoma mansoni	zinc finger protein	0.0596	0.3745	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0221	0.1305	0.2366
Plasmodium vivax	hypothetical protein, conserved	0.01	0.0511	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0043	0.0139	0.0187
Echinococcus granulosus	microtubule associated protein 2	0.0589	0.3699	0.6709
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.0123	0.1823
Mycobacterium tuberculosis	Conserved protein	0.01	0.0511	0.1094
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.01	0.0514	0.1371
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0221	0.1305	0.3483
Schistosoma mansoni	lipoxygenase	0.0074	0.0345	0.0921
Brugia malayi	Pre-SET motif family protein	0.0187	0.1081	0.1907
Schistosoma mansoni	ap endonuclease	0.0056	0.0227	0.0606
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0042	0.0139	0.0237
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0056	0.0227	0.0227
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.01	0.0514	0.087
Schistosoma mansoni	microtubule-associated protein tau	0.0589	0.3699	0.9877
Echinococcus multilocularis		0.0034	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.01	0.0511	0.0866
Trypanosoma cruzi	cytochrome P450, putative	0.0049	0.0181	0.0642
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0039	0.0113	0.0527
Trichomonas vaginalis	D-aminoacylase, putative	0.01	0.0511	0.3512
Onchocerca volvulus		0.0043	0.0145	0.0888
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0091	0.0458	0.0959
Echinococcus multilocularis	survival motor neuron protein 1	0.0213	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.01	0.0514	0.087
Toxoplasma gondii	ABC1 family protein	0.01	0.0511	0.8852
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0051	0.0197	0.0357
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0596	0.3745	0.6792
Mycobacterium ulcerans	beta-lactamase	0.01	0.0511	0.6033
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.01	0.0514	0.2788
Trypanosoma cruzi	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.01	0.0511	0.1094
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0056	0.0227	0.5
Echinococcus multilocularis	snurportin 1	0.0559	0.3504	0.3504
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0051	0.0197	0.0747
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.01	0.0514	0.3532
Trypanosoma cruzi	GUP1, putative	0.0051	0.0197	0.0743
Loa Loa (eye worm)	MBOAT family protein	0.0596	0.3745	0.6771
Brugia malayi	glutathione reductase	0.004	0.0123	0.0158
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.01	0.0514	0.2788
Schistosoma mansoni	transcription factor LCR-F1	0.0162	0.0921	0.246
Echinococcus granulosus	zinc finger protein	0.0544	0.3411	0.6186
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0181	0.0263
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0039	0.0113	0.0204
Brugia malayi	exodeoxyribonuclease III family protein	0.0056	0.0227	0.0347
Loa Loa (eye worm)	hhat protein	0.0051	0.0197	0.0292
Echinococcus multilocularis	importin subunit beta 1	0.0052	0.0203	0.0203
Loa Loa (eye worm)	CYP4Cod1	0.0049	0.0181	0.0263
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.01	0.0514	0.0931
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0039	0.0113	0.0139
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0091	0.0458	0.0959
Mycobacterium tuberculosis	Probable dehydrogenase	0.0091	0.0458	0.0959
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0162	0.0921	0.0921
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0197	0.0747
Trichomonas vaginalis	ran, putative	0.0039	0.0113	0.0013
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0056	0.0227	0.0347
Leishmania major	mitochondrial DNA polymerase beta	0.0271	0.1631	1
Leishmania major	cytochrome p450-like protein	0.0049	0.0181	0.0642
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0038	0.0112	0.0203
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0051	0.0197	0.0292
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0181	0.0263
Plasmodium vivax	ataxin-2 like protein, putative	0.0047	0.017	0.2797
Trichomonas vaginalis	esterase, putative	0.01	0.0511	0.3512
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.01	0.0511	0.0866
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.01	0.0511	0.1094
Echinococcus granulosus	histone lysine methyltransferase setb	0.0027	0.0037	0.0067
Schistosoma mansoni	eyes absent homolog	0.0074	0.0347	0.0927
Entamoeba histolytica	hypothetical protein, conserved	0.0051	0.0197	0.1274
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0042	0.0139	0.0237
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0047	0.0165	0.054
Mycobacterium tuberculosis	Probable oxidoreductase	0.0102	0.0525	0.1128
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0051	0.0197	0.0357
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0038	0.0111	0.0189
Loa Loa (eye worm)	cytochrome P450 family protein	0.0133	0.0726	0.1258
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0106	0.0553	0.0553
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0027	0.0037	0.0037
Schistosoma mansoni	ap endonuclease	0.0056	0.0227	0.0606
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0056	0.0227	0.0937
Loa Loa (eye worm)	acetyltransferase	0.013	0.0711	0.1231
Loa Loa (eye worm)	hypothetical protein	0.01	0.0511	0.0866
Brugia malayi	hypothetical protein	0.003	0.0061	0.0043
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0026	0.003	0.0055
Trypanosoma brucei	importin beta-1 subunit, putative	0.0052	0.0203	0.0785
Schistosoma mansoni	survival motor neuron protein	0.0043	0.0145	0.0386
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0109	0.0573	0.6897
Plasmodium falciparum	thioredoxin reductase	0.004	0.0123	0.2392
Schistosoma mansoni	hypothetical protein	0.0165	0.0939	0.2508
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0043	0.0139	0.0187
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.01	0.0511	0.1365
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0109	0.0573	0.6897
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.01	0.0514	0.3532
Trypanosoma brucei	glycerol uptake protein, putative	0.0051	0.0197	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0047	0.017	0.0242
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.01	0.0514	0.1371
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.01	0.0511	0.6033
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0027	0.0037	0.0099
Plasmodium vivax	importin-beta 2, putative	0.0052	0.0203	0.3506
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0051	0.0197	0.0197
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0051	0.0197	0.0357
Schistosoma mansoni	hypothetical protein	0.0051	0.0197	0.0525
Schistosoma mansoni	aldehyde dehydrogenase	0.0109	0.0573	0.1529
Onchocerca volvulus	Huntingtin homolog	0.0116	0.0617	0.478
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0091	0.0458	0.8499
Loa Loa (eye worm)	hypothetical protein	0.01	0.0511	0.0866
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0051	0.0197	0.0197
Toxoplasma gondii	thioredoxin reductase	0.004	0.0123	0.1614
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0128	0.0699	0.3986
Mycobacterium tuberculosis	Probable lipase LipD	0.01	0.0511	0.1094
Toxoplasma gondii	LsmAD domain-containing protein	0.0047	0.017	0.2476
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0056	0.0227	0.037
Trypanosoma brucei	PAB1-binding protein , putative	0.0047	0.017	0.0568
Trichomonas vaginalis	D-aminoacylase, putative	0.01	0.0511	0.3512
Trichomonas vaginalis	penicillin-binding protein, putative	0.01	0.0511	0.3512
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0051	0.0197	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0197	0.0292
Echinococcus multilocularis	thioredoxin glutathione reductase	0.004	0.0123	0.0123
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0271	0.1631	1
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0051	0.0197	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0867	0.5514	1
Leishmania major	hypothetical protein, conserved	0.01	0.0511	0.2773
Schistosoma mansoni	hypothetical protein	0.0034	0.0082	0.0218
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0127	0.0687	0.1246
Brugia malayi	hypothetical protein	0.0162	0.0921	0.1615
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0271	0.1631	1
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0051	0.0197	0.1274
Trypanosoma cruzi	cytochrome P450, putative	0.0049	0.0181	0.0642

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 840160