TDR Targets

Basic information

Technical information

TDR Targets ID: 843446
Name: ethyl 4-[(9-methyl4H-thieno[4,5-c]chromene-2- carbonyl)amino]benzoate
MW: 393.456 | Formula: C22H19NO4S
H donors: 1 H acceptors: 2 LogP: 4.56 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1ccc(cc1)NC(=O)c1cc2c(s1)c1c(C)cccc1OC2
InChi: 1S/C22H19NO4S/c1-3-26-22(25)14-7-9-16(10-8-14)23-21(24)18-11-15-12-27-17-6-4-5-13(2)19(17)20(15)28-18/h4-11H,3,12H2,1-2H3,(H,23,24)
InChiKey: MIZNUBVNGSYAEO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[(9-methyl-4H-thieno[4,5-c]chromen-2-yl)-oxomethyl]amino]benzoic acid ethyl ester
4-[(9-methyl4H-thieno[4,5-c]chromene-2-carbonyl)amino]benzoic acid ethyl ester
ethyl 4-[(9-methyl-4H-thieno[4,5-c]chromen-2-yl)carbonylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	beta tubulin	0.0345	0.663	1
Echinococcus multilocularis	tubulin alpha	0.0193	0.3539	0.5338
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Trichomonas vaginalis	tubulin gamma chain, putative	0.0193	0.3539	0.5203
Loa Loa (eye worm)	tubulin alpha 2	0.0191	0.3504	0.5286
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0274	0.5199	0.7779
Brugia malayi	beta-tubulin, identical	0.0345	0.663	1
Echinococcus granulosus	tubulin alpha chain	0.0274	0.5199	0.7841
Loa Loa (eye worm)	blistered cuticle protein 3	0.0086	0.137	0.2066
Leishmania major	beta tubulin	0.0345	0.663	1
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.137	0.2066
Schistosoma mansoni	alpha tubulin	0.0274	0.5199	0.7841
Echinococcus granulosus	tubulin gamma 1 chain	0.0193	0.3539	0.5338
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.137	0.2066
Trypanosoma cruzi	tubulin delta chain	0.0084	0.1331	0.2007
Echinococcus granulosus	tubulin epsilon chain	0.0193	0.3539	0.5338
Echinococcus multilocularis	tubulin beta 1 chain	0.0345	0.663	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0274	0.5199	0.7841
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0274	0.5199	0.7779
Toxoplasma gondii	beta-1 tubulin, putative	0.0345	0.663	1
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Echinococcus granulosus	peroxisome assembly protein 26	0.0274	0.5199	0.7841
Brugia malayi	Tubulin beta chain	0.0109	0.1845	0.2783
Entamoeba histolytica	tubulin gamma chain	0.0193	0.3539	0.5203
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0062	0.0894	0.1098
Trichomonas vaginalis	tubulin, putative	0.0109	0.1845	0.2574
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0274	0.5199	0.7841
Trypanosoma brucei	zeta tubulin	0.0084	0.1331	0.2007
Echinococcus multilocularis	beta tubulin	0.0345	0.663	1
Plasmodium falciparum	tubulin delta chain, putative	0.0084	0.1331	0.2007
Trypanosoma cruzi	calmodulin, putative	0.0027	0.0186	0.028
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Leishmania major	delta tubulin, putative	0.0084	0.1331	0.2007
Echinococcus granulosus	Protein patched homolog 1	0.0054	0.074	0.1116
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0191	0.3504	0.5286
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Echinococcus multilocularis	tubulin alpha 1C chain	0.0274	0.5199	0.7841
Leishmania major	beta tubulin	0.0345	0.663	1
Schistosoma mansoni	peroxidasin	0.0086	0.137	0.2066
Echinococcus multilocularis	Tubulin beta 2C chain	0.0345	0.663	1
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0132	0.2316	1
Loa Loa (eye worm)	tubulin alpha 2	0.0082	0.1297	0.1956
Trypanosoma brucei	beta tubulin	0.0345	0.663	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0345	0.663	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0345	0.663	1
Schistosoma mansoni	hypothetical protein	0.0192	0.3534	0.5331
Loa Loa (eye worm)	hypothetical protein	0.0166	0.2991	0.4511
Trichomonas vaginalis	tubulin alpha chain, putative	0.0193	0.3539	0.5203
Leishmania major	beta tubulin	0.0345	0.663	1
Echinococcus granulosus	tubulin subunit TubB	0.0274	0.5199	0.7841
Loa Loa (eye worm)	tubulin beta chain	0.0084	0.1331	0.2008
Toxoplasma gondii	beta tubulin	0.0345	0.663	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	0.2383	0.3594
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Trypanosoma brucei	tubulin delta chain	0.0084	0.1331	0.2007
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0001	0.0001
Loa Loa (eye worm)	tubulin gamma chain	0.0193	0.3539	0.5338
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	0.2383	0.3594
Plasmodium falciparum	tubulin beta chain	0.0345	0.663	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0191	0.3504	0.515
Onchocerca volvulus	Calmodulin homolog	0.0027	0.0186	0.0002
Schistosoma mansoni	peroxidasin	0.0086	0.137	0.2066
Brugia malayi	Tubulin alpha-2 chain	0.0274	0.5199	0.7841
Plasmodium vivax	tubulin alpha chain, putative	0.0274	0.5199	0.7841
Echinococcus granulosus	tubulin subunit beta	0.0345	0.663	1
Brugia malayi	Tubulin gamma chain	0.0193	0.3539	0.5338
Echinococcus granulosus	geminin	0.0192	0.3534	0.5331
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.137	0.2066
Leishmania major	beta tubulin	0.0345	0.663	1
Brugia malayi	Blistered cuticle protein 3	0.0086	0.137	0.2066
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.137	0.2066
Echinococcus granulosus	tubulin delta chain	0.0084	0.1331	0.2008
Echinococcus granulosus	tubulin alpha 1C chain	0.0274	0.5199	0.7841
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0001	0.0001
Echinococcus granulosus	tubulin alpha 3 chain	0.0274	0.5199	0.7841
Trypanosoma brucei	alpha tubulin	0.0274	0.5199	0.7841
Trichomonas vaginalis	tubulin alpha chain, putative	0.0109	0.1845	0.2574
Trichomonas vaginalis	tubulin beta chain, putative	0.0274	0.5199	0.7779
Echinococcus granulosus	tubulin alpha chain	0.0274	0.5199	0.7841
Schistosoma mansoni	tubulin subunit beta	0.0084	0.1331	0.2008
Echinococcus granulosus	beta tubulin	0.0345	0.663	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0345	0.663	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0193	0.3539	0.5338
Leishmania major	beta tubulin	0.0345	0.663	1
Brugia malayi	alpha-tubulin	0.0274	0.5199	0.7841
Plasmodium vivax	tubulin epsilon chain, putative	0.0193	0.3539	0.5338
Trichomonas vaginalis	tubulin gamma chain, putative	0.0084	0.1331	0.1777
Trypanosoma brucei	tubulin gamma chain	0.0193	0.3539	0.5338
Schistosoma mansoni	calmodulin	0.0027	0.0186	0.0281
Loa Loa (eye worm)	tubulin alpha 2	0.0191	0.3504	0.5286
Echinococcus granulosus	tubulin beta 4A class IVa	0.0345	0.663	1
Plasmodium falciparum	calmodulin	0.0027	0.0186	0.028
Schistosoma mansoni	tubulin subunit beta	0.0345	0.663	1
Trypanosoma cruzi	calmodulin, putative	0.0027	0.0186	0.028
Toxoplasma gondii	alpha-tubulin I, putative	0.0274	0.5199	0.7841
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0345	0.663	1
Plasmodium vivax	tubulin gamma chain, putative	0.0193	0.3539	0.5338
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0084	0.1331	0.2007
Brugia malayi	Tubulin beta chain	0.0084	0.1331	0.2008
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0073	0.1108	0.1671
Loa Loa (eye worm)	tubulin beta chain	0.0345	0.663	1
Trypanosoma brucei	alpha tubulin	0.0274	0.5199	0.7841
Echinococcus multilocularis	calmodulin	0.0027	0.0186	0.0281
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0132	0.2316	0.3492
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.1331	0.1777
Echinococcus multilocularis	protein dispatched 1	0.0054	0.074	0.1116
Trypanosoma brucei	calmodulin	0.0027	0.0186	0.028
Echinococcus granulosus	beta tubulin	0.0345	0.663	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.074	0.1116
Entamoeba histolytica	tubulin family protein	0.0345	0.663	1
Onchocerca volvulus		0.0109	0.1845	0.5669
Schistosoma mansoni	tubulin subunit alpha	0.0274	0.5199	0.7841
Loa Loa (eye worm)	BEN-1 protein	0.0345	0.663	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0193	0.3539	0.5203
Mycobacterium leprae	cell division protein FtsZ	0.0084	0.1331	0.5
Trypanosoma brucei	calmodulin	0.0027	0.0186	0.028
Giardia lamblia	Alpha-tubulin	0.0274	0.5199	0.7779
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0073	0.1108	0.1671
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0784	0.1182
Schistosoma mansoni	tubulin subunit beta	0.0345	0.663	1
Schistosoma mansoni	alpha tubulin	0.0274	0.5199	0.7841
Trypanosoma cruzi	zeta tubulin, putative	0.0084	0.1331	0.2007
Trypanosoma cruzi	beta tubulin, putative	0.0345	0.663	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0193	0.3539	0.5338
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0132	0.2316	0.3492
Leishmania major	gamma-tubulin	0.0193	0.3539	0.5338
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0132	0.2316	0.3492
Leishmania major	beta tubulin	0.0345	0.663	1
Trichomonas vaginalis	tubulin, putative	0.0345	0.663	1
Leishmania major	beta tubulin	0.0345	0.663	1
Echinococcus multilocularis	tubulin alpha chain	0.0274	0.5199	0.7841
Toxoplasma gondii	calmodulin, putative	0.0027	0.0186	0.028
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0274	0.5199	0.7841
Schistosoma mansoni	hypothetical protein	0.0039	0.0421	0.0635
Plasmodium vivax	delta tubulin, putative	0.0084	0.1331	0.2007
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0132	0.2316	0.3492
Leishmania major	calmodulin, putative	0.0027	0.0186	0.028
Echinococcus granulosus	sterol regulatory element binding protein	0.0054	0.074	0.1116
Echinococcus multilocularis	tubulin alpha chain	0.0274	0.5199	0.7841
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.137	0.2066
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0274	0.5199	0.7841
Trichomonas vaginalis	tubulin beta chain, putative	0.0345	0.663	1
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0084	0.1331	0.1777
Onchocerca volvulus	Dual oxidase homolog	0.0086	0.137	0.4046
Echinococcus multilocularis	tubulin epsilon chain	0.0193	0.3539	0.5338
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0345	0.663	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0345	0.663	1
Echinococcus multilocularis	peroxidasin	0.0086	0.137	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0784	0.1182
Echinococcus multilocularis	calmodulin	0.0027	0.0186	0.0281
Giardia lamblia	Alpha-tubulin	0.0274	0.5199	0.7779
Brugia malayi	hypothetical protein	0.0172	0.3113	0.4695
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0193	0.3539	0.5338
Brugia malayi	MH2 domain containing protein	0.0136	0.2383	0.3594
Echinococcus multilocularis	calmodulin	0.0027	0.0186	0.0281
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Onchocerca volvulus		0.0086	0.137	0.4046
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0345	0.663	1
Leishmania major	calmodulin, putative	0.0027	0.0186	0.028
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0001	0.0001
Onchocerca volvulus	Chorion peroxidase homolog	0.0086	0.137	0.4046
Echinococcus granulosus	CalModulin family member cmd 1	0.0027	0.0186	0.0281
Echinococcus granulosus	calmodulin	0.0027	0.0186	0.0281
Trichomonas vaginalis	tubulin, putative	0.0084	0.1331	0.1777
Brugia malayi	hypothetical protein	0.0086	0.137	0.2066
Brugia malayi	Tubulin alpha chain	0.0084	0.1331	0.2008
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Echinococcus multilocularis	calmodulin	0.0027	0.0186	0.0281
Plasmodium falciparum	tubulin gamma chain	0.0193	0.3539	0.5338
Echinococcus multilocularis	tubulin alpha chain	0.0274	0.5199	0.7841
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0132	0.2316	0.3493
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0166	0.2991	0.4352
Echinococcus multilocularis	tubulin delta chain	0.0084	0.1331	0.2008
Leishmania major	beta tubulin	0.0345	0.663	1
Echinococcus granulosus	calmodulin	0.0027	0.0186	0.0281
Plasmodium falciparum	alpha tubulin 1	0.0274	0.5199	0.7841
Echinococcus granulosus	peroxidasin	0.0086	0.137	0.2066
Plasmodium vivax	tubulin beta chain, putative	0.0345	0.663	1
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0001	0.0001
Trichomonas vaginalis	tubulin beta chain, putative	0.0274	0.5199	0.7779
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.137	0.2066
Loa Loa (eye worm)	tubulin alpha chain	0.0274	0.5199	0.7841
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0084	0.1331	0.2007
Leishmania major	beta tubulin	0.0345	0.663	1
Trypanosoma cruzi	zeta tubulin, putative	0.0084	0.1331	0.2007
Schistosoma mansoni	tubulin subunit gamma	0.0193	0.3539	0.5338
Loa Loa (eye worm)	hypothetical protein	0.0132	0.2316	0.3493
Leishmania major	beta tubulin	0.0345	0.663	1
Echinococcus multilocularis	tubulin alpha chain	0.0274	0.5199	0.7841
Onchocerca volvulus		0.0086	0.137	0.4046
Trypanosoma brucei	alpha tubulin, putative	0.0109	0.1845	0.2782
Echinococcus multilocularis	calmodulin	0.0027	0.0186	0.028
Echinococcus multilocularis	tubulin alpha chain	0.0274	0.5199	0.7841
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0784	0.1182
Loa Loa (eye worm)	alpha-tubulin	0.0274	0.5199	0.7841
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0132	0.2316	0.3493
Loa Loa (eye worm)	beta-tubulin	0.0345	0.663	1
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0132	0.2316	0.3493
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0109	0.1845	0.2574
Echinococcus multilocularis	CalModulin family member (cmd 1)	0.0027	0.0186	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Leishmania major	beta tubulin	0.0345	0.663	1
Leishmania major	calmodulin, putative	0.0027	0.0186	0.028
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Trypanosoma brucei	beta tubulin	0.0345	0.663	1
Brugia malayi	calmodulin	0.0027	0.0186	0.0281
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0166	0.2991	0.4511
Trichomonas vaginalis	tubulin beta chain, putative	0.0109	0.1845	0.2574
Trypanosoma brucei	epsilon tubulin	0.0193	0.3539	0.5338
Trypanosoma brucei	zeta tubulin, putative	0.0084	0.1331	0.2007
Onchocerca volvulus	Peroxidase homolog	0.0086	0.137	0.4046
Schistosoma mansoni	tubulin subunit alpha	0.0274	0.5199	0.7841
Echinococcus multilocularis	hypothetical protein	0.0274	0.5199	0.7841
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0784	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Echinococcus multilocularis	Tubulin beta 2C chain	0.0345	0.663	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0345	0.663	1
Giardia lamblia	Delta tubulin	0.0084	0.1331	0.1777
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0062	0.0894	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3113	0.4695
Schistosoma mansoni	tubulin subunit delta	0.0084	0.1331	0.2008
Echinococcus granulosus	Tubulin beta 2C chain	0.0345	0.663	1
Schistosoma mansoni	hypothetical protein	0.0192	0.3534	0.5331
Brugia malayi	Peroxidasin	0.0086	0.137	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0421	0.0635
Leishmania major	beta tubulin	0.0345	0.663	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0109	0.1845	0.2574
Trichomonas vaginalis	tubulin beta chain, putative	0.0274	0.5199	0.7779
Echinococcus granulosus	tubulin alpha 1C chain	0.0274	0.5199	0.7841
Trichomonas vaginalis	tubulin beta chain, putative	0.0274	0.5199	0.7779
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0001	0.0001
Trypanosoma brucei	alpha tubulin	0.0274	0.5199	0.7841
Schistosoma mansoni	patched 1	0.0054	0.074	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0186	0.0281
Trypanosoma cruzi	tubulin delta chain	0.0084	0.1331	0.2007
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0001	0.0001
Echinococcus multilocularis	Tubulin beta 2C chain	0.0345	0.663	1
Trypanosoma brucei	beta tubulin	0.0345	0.663	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0274	0.5199	0.7779
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.137	0.2066
Leishmania major	beta tubulin	0.0345	0.663	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.3504	0.5286
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5199	0.7841
Toxoplasma gondii	alpha tubulin TUBA1	0.0274	0.5199	0.7841
Giardia lamblia	Beta tubulin	0.0345	0.663	1
Echinococcus granulosus	tubulin alpha chain	0.0274	0.5199	0.7841
Echinococcus granulosus	calmodulin	0.0027	0.0186	0.028
Schistosoma mansoni	tubulin subunit alpha	0.0274	0.5199	0.7841
Loa Loa (eye worm)	alpha-tubulin	0.0274	0.5199	0.7841
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.137	0.2066
Trichomonas vaginalis	tubulin alpha chain, putative	0.0345	0.663	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0054	0.074	0.1116
Echinococcus multilocularis	tubulin alpha 3 chain	0.0274	0.5199	0.7841
Onchocerca volvulus		0.0172	0.3113	1
Brugia malayi	Tubulin alpha chain	0.0274	0.5199	0.7841
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0054	0.074	0.1116
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0054	0.074	0.1116
Echinococcus multilocularis	beta tubulin	0.0345	0.663	1
Trypanosoma brucei	beta tubulin	0.0345	0.663	1
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Loa Loa (eye worm)	tubulin alpha chain	0.0274	0.5199	0.7841
Brugia malayi	tubulin alpha-2 chain	0.0274	0.5199	0.7841
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Echinococcus granulosus	tubulin alpha	0.0193	0.3539	0.5338
Leishmania major	beta tubulin	0.0345	0.663	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Schistosoma mansoni	tubulin subunit beta	0.0345	0.663	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Leishmania major	beta tubulin	0.0345	0.663	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0274	0.5199	0.7841
Echinococcus multilocularis	Niemann Pick C1 protein	0.0054	0.074	0.1116
Echinococcus multilocularis	tubulin subunit beta	0.0345	0.663	1
Schistosoma mansoni	tubulin subunit alpha	0.0084	0.1331	0.2008
Echinococcus multilocularis	Tubulin beta 2C chain	0.0345	0.663	1
Plasmodium vivax	tubulin alpha chain, putative	0.0274	0.5199	0.7841
Echinococcus multilocularis	calmodulin	0.0027	0.0186	0.0281
Echinococcus granulosus	tubulin alpha chain	0.0274	0.5199	0.7841
Onchocerca volvulus	Peroxidasin homolog	0.0086	0.137	0.4046
Onchocerca volvulus	Peroxidase homolog	0.0086	0.137	0.4046
Trichomonas vaginalis	tubulin beta chain, putative	0.0274	0.5199	0.7779
Trypanosoma cruzi	calmodulin, putative	0.0027	0.0186	0.028
Onchocerca volvulus		0.0086	0.137	0.4046
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0062	0.0894	0.1098
Echinococcus granulosus	alpha tubulin	0.0274	0.5199	0.7841
Echinococcus granulosus	Tubulin alpha 1 chain	0.0274	0.5199	0.7841
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Schistosoma mansoni	tubulin subunit beta	0.0345	0.663	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0274	0.5199	0.7841
Leishmania major	epsilon tubulin, putative	0.0193	0.3539	0.5338
Echinococcus granulosus	tubulin beta 1 chain	0.0345	0.663	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0193	0.3539	0.5338
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Loa Loa (eye worm)	BEN-1 protein	0.0345	0.663	1
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.1331	0.1777
Leishmania major	zeta tubulin, putative	0.0084	0.1331	0.2007
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0084	0.1331	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0274	0.5199	0.7841
Trypanosoma brucei	calmodulin	0.0027	0.0186	0.028
Trypanosoma cruzi	tubulin gamma chain	0.0193	0.3539	0.5338
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0084	0.1331	0.1777
Trichomonas vaginalis	tubulin, putative	0.0109	0.1845	0.2574
Trypanosoma cruzi	calmodulin	0.0027	0.0186	0.028
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0001	0.0001
Entamoeba histolytica	tubulin alpha chain, putative	0.0274	0.5199	0.7779
Echinococcus multilocularis	tubulin subunit TubB	0.0274	0.5199	0.7841
Echinococcus multilocularis	protein patched	0.0054	0.074	0.1116
Toxoplasma gondii	beta-tubulin, putative	0.0345	0.663	1
Brugia malayi	Cell division protein ftsZ	0.0084	0.1331	0.2008
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Echinococcus granulosus	tubulin alpha chain	0.0274	0.5199	0.7841
Trypanosoma cruzi	calmodulin	0.0027	0.0186	0.028
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0001	0.0001
Trypanosoma brucei	epsilon tubulin	0.0193	0.3539	0.5338
Echinococcus multilocularis	Tubulin beta 2C chain	0.0345	0.663	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0274	0.5199	0.7779
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Echinococcus granulosus	Niemann Pick C1 protein	0.0054	0.074	0.1116
Brugia malayi	CHE-14 protein	0.0054	0.074	0.1116
Onchocerca volvulus	Peroxidasin homolog	0.0086	0.137	0.4046
Giardia lamblia	Beta tubulin	0.0345	0.663	1
Echinococcus multilocularis	geminin	0.0192	0.3534	0.5331
Trypanosoma brucei	alpha tubulin	0.0274	0.5199	0.7841
Echinococcus granulosus	Tubulin beta 2C chain	0.0345	0.663	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Trypanosoma brucei	epsilon tubulin	0.0193	0.3539	0.5338
Trichomonas vaginalis	tubulin alpha chain, putative	0.0109	0.1845	0.2574
Trypanosoma cruzi	alpha tubulin, putative	0.0274	0.5199	0.7841
Brugia malayi	Tubulin beta-1 chain	0.0345	0.663	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.137	0.2066
Plasmodium vivax	calmodulin, putative	0.0027	0.0186	0.028
Entamoeba histolytica	tubulin family protein	0.0345	0.663	1
Echinococcus granulosus	calmodulin	0.0027	0.0186	0.0281
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0274	0.5199	0.7841
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0001	0.0001
Echinococcus granulosus	Tubulin beta 2C chain	0.0345	0.663	1
Brugia malayi	Tubulin alpha-2 chain	0.0274	0.5199	0.7841
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Giardia lamblia	Epsilon tubulin	0.0084	0.1331	0.1777
Schistosoma mansoni	tubulin subunit beta	0.0345	0.663	1
Trypanosoma brucei	calmodulin	0.0027	0.0186	0.028
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.074	0.0859
Trypanosoma cruzi	epsilon tubulin, putative	0.0193	0.3539	0.5338
Trichomonas vaginalis	tubulin beta chain, putative	0.0274	0.5199	0.7779
Trypanosoma brucei	beta tubulin	0.0193	0.3539	0.5338
Giardia lamblia	Gamma tubulin	0.0193	0.3539	0.5203
Brugia malayi	tubulin alpha chain - mouse	0.0274	0.5199	0.7841
Schistosoma mansoni	alpha tubulin	0.0274	0.5199	0.7841
Loa Loa (eye worm)	tubulin beta-1 chain	0.0345	0.663	1
Giardia lamblia	Beta tubulin	0.0345	0.663	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0274	0.5199	0.7841
Echinococcus granulosus	Tubulin alpha 1 chain	0.0274	0.5199	0.7841
Schistosoma mansoni	tubulin subunit beta	0.0345	0.663	1
Leishmania major	beta tubulin	0.0345	0.663	1
Leishmania major	beta tubulin	0.0345	0.663	1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0062	0.0894	0.1098
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0421	0.0635
Leishmania major	alpha tubulin	0.0274	0.5199	0.7841
Schistosoma mansoni	tubulin subunit epsilon	0.0193	0.3539	0.5338
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0132	0.2316	0.3493
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.137	0.2066
Plasmodium falciparum	alpha tubulin 2	0.0274	0.5199	0.7841
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0084	0.1331	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 843446