Detailed information for compound 846879

Basic information

Technical information
  • TDR Targets ID: 846879
  • Name: CBMicro_019815
  • MW: 255.269 | Formula: C15H13NO3
  • H donors: 0 H acceptors: 2 LogP: 0.89 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(c2ccccc2)C(=O)C2C1C1C=CC2(O1)C
  • InChi: 1S/C15H13NO3/c1-15-8-7-10(19-15)11-12(15)14(18)16(13(11)17)9-5-3-2-4-6-9/h2-8,10-12H,1H3
  • InChiKey: JXNRULRHASYXOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_526773
  • BIM-0019590.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0116 0.0326 0.2936
Loa Loa (eye worm) ctsf protein 0.0019 0.0023 0.002
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0049 0.0117 0.1055
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0023 0.0094
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0189 0.077
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0135 0.0384 0.3459
Onchocerca volvulus 0.0179 0.0523 0.5699
Brugia malayi conserved hypotetical protein 0.0016 0.0013 0.001
Leishmania major cathepsin L-like protease 0.0019 0.0023 0.1072
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0072 0.019 0.0187
Loa Loa (eye worm) hypothetical protein 0.0051 0.0121 0.0119
Brugia malayi Cathepsin L-like precursor 0.0019 0.0023 0.002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0024 0.0098
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0036
Brugia malayi hypothetical protein 0.0016 0.0013 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0068 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0013 0.0051
Schistosoma mansoni hypothetical protein 0.0072 0.019 0.0187
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Echinococcus granulosus voltage dependent calcium channel 0.0024 0.0039 0.0353
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Onchocerca volvulus 0.0019 0.0023 0.0217
Leishmania major cathepsin L-like protease 0.0019 0.0023 0.1072
Toxoplasma gondii transporter, cation channel family protein 0.0024 0.0039 0.2995
Leishmania major cathepsin L-like protease 0.0019 0.0023 0.1072
Entamoeba histolytica cysteine protease, putative 0.0019 0.0023 0.1977
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0068 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Leishmania major cathepsin L-like protease 0.0073 0.0191 1
Schistosoma mansoni hypothetical protein 0.0367 0.1112 0.1109
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0024 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0068 0.0611
Brugia malayi ecdysteroid receptor 0.0033 0.0068 0.0065
Brugia malayi nuclear hormone receptor 0.0033 0.0068 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0065
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0116 0.0326 0.2936
Schistosoma mansoni zinc finger protein 0.0016 0.0013 0.001
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0071 0.0184 0.9599
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0068 0.0709
Brugia malayi nuclear receptor NHR-67 0.0016 0.0013 0.001
Loa Loa (eye worm) fibroinase 0.0019 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0065
Onchocerca volvulus 0.0019 0.0023 0.0217
Brugia malayi Bromodomain containing protein 0.0048 0.0113 0.011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0065
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0018 0.0166
Entamoeba histolytica hypothetical protein 0.0035 0.0074 0.7055
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.019 0.0187
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0068 0.0611
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0074 0.0664
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0013 0.001
Brugia malayi hypothetical protein 0.0023 0.0034 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0081 0.0216 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0068 0.0065
Schistosoma mansoni voltage-gated cation channel 0.0116 0.0326 0.0324
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0068 0.0065
Brugia malayi hypothetical protein 0.0179 0.0523 0.052
Brugia malayi nuclear receptor RXR 0.0016 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Echinococcus multilocularis GPCR, family 2 0.0034 0.0068 0.0278
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0023 0.002
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0116 0.0326 0.1329
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0034 0.0137
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0013 0.001
Onchocerca volvulus 0.0019 0.0023 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0023 0.0217
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0068 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0068 0.0065
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0013 0.0113
Schistosoma mansoni hypothetical protein 0.0024 0.0037 0.0034
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0116 0.0326 0.1329
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0013 0.001
Schistosoma mansoni polycystin 1-related 0.0023 0.0034 0.0031
Echinococcus granulosus cGMP dependent protein kinase 1 0.0013 0.0003 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0068 0.0065
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0127 0.0124
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0052 0.0124 1
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0013 0.001
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0142 0.7185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0013 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.0405 0.0403
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0068 0.0276
Brugia malayi N-terminal motif family protein 0.0177 0.0518 0.0515
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0065
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0295 0.0292
Schistosoma mansoni rab6-interacting 0.0023 0.0034 0.0031
Brugia malayi hypothetical protein 0.0018 0.0018 0.0016
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0052 0.0124 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0068 0.0065
Brugia malayi Bromodomain containing protein 0.009 0.0244 0.0241
Brugia malayi hypothetical protein 0.0995 0.3077 0.3075
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0068 0.0709
Echinococcus multilocularis Cyclin dependent kinase 2 associated protein 0.0304 0.0915 0.3726
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0068 0.0065
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0013 0.0113
Brugia malayi hypothetical protein 0.0023 0.0034 0.0031
Brugia malayi Cathepsin L-like precursor 0.0019 0.0023 0.002
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0018 0.0075
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0068 0.0065
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.3207 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0068 0.0611
Echinococcus granulosus voltage dependent calcium channel 0.0116 0.0326 0.2936
Brugia malayi tailless protein 0.0016 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0068 0.0065
Echinococcus multilocularis voltage dependent calcium channel 0.0116 0.0326 0.1329
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0034 0.0137
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0013 0.001
Echinococcus multilocularis expressed conserved protein 0.0013 0.0003 0.0011
Brugia malayi nuclear hormone receptor 0.0016 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0068 0.0065
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0013 0.0103
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0191 1
Brugia malayi Doublecortin family protein 0.0023 0.0034 0.0031
Entamoeba histolytica hypothetical protein 0.0035 0.0074 0.7055
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0023 0.0217
Schistosoma mansoni bromodomain containing protein 0.0076 0.0202 0.0199
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0068 0.0065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0068 0.0611
Loa Loa (eye worm) cysteine protease 0.0019 0.0023 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0074 0.03
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0018 0.0016
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0116 0.0326 0.1329
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0023 0.1632
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0171 0.8859
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0021
Echinococcus multilocularis RUN 0.0023 0.0034 0.0137
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0013 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0068 0.0611
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0116 0.0326 0.0324
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0068 0.0065
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0191 1
Onchocerca volvulus 0.0023 0.0034 0.0333
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0039 0.0036
Brugia malayi nuclear receptor NHR-88 0.0016 0.0013 0.001
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0068 0.0065
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0023 0.201
Loa Loa (eye worm) hypothetical protein 0.0106 0.0295 0.0292
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0068 0.0276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0127 0.0515
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.2456 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0326 0.0324
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0034 0.1047
Echinococcus granulosus cathepsin l1 0.0013 0.0003 0.0029
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0023 0.0207
Toxoplasma gondii cathepsin CPL 0.0019 0.0023 0.166
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Schistosoma mansoni coup transcription factor 0.0033 0.0068 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0191 1
Schistosoma mansoni serine/threonine protein kinase 0.3207 1 1
Loa Loa (eye worm) acetyltransferase 0.0169 0.0491 0.0488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0127 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0068 0.0065
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0068 0.0611
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0068 0.0065
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0068 0.0611
Brugia malayi hypothetical protein 0.0035 0.0074 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0023 0.1632
Brugia malayi nuclear receptor NHR-88 0.0033 0.0068 0.0065
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0068 0.0613
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0016
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0034 0.3067
Echinococcus granulosus cathepsin l1 0.0019 0.0023 0.0207
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0023 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0023 0.002
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0023 0.0207
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.002
Leishmania major cathepsin L-like protease 0.0019 0.0023 0.1072
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0013 0.001
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.0518 0.5647
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0068 0.0065
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0068 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0068 0.0065
Toxoplasma gondii hypothetical protein 0.0021 0.003 0.224
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0024 0.0021
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0023 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0068 0.0065
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0034 0.0302
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0013 0.0051
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0103 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0068 0.0065
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0018 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0127 0.0515
Brugia malayi ecdysone receptor 0.0016 0.0013 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0068 0.0065
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0023 0.0094
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0013 0.001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0044 0.0178
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0068 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0068 0.0065
Onchocerca volvulus 0.0016 0.0013 0.0103
Echinococcus granulosus cGMP dependent protein kinase 0.0013 0.0003 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0116 0.0326 0.0324
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0068 0.0065
Echinococcus granulosus Cyclin dependent kinase 2 associated protein 0.0304 0.0915 0.823
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0016
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0068 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0116 0.0326 0.1329
Echinococcus multilocularis cysteine protease 0.0019 0.0023 0.0094
Echinococcus granulosus zinc finger protein 0.0026 0.0046 0.0412
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0127 0.1139
Schistosoma mansoni rab6-interacting 0.0023 0.0034 0.0031
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.0491 0.0488
Echinococcus multilocularis cysteine protease 0.0019 0.0023 0.0094
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0071 0.0184 0.9599
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0116 0.0326 0.0324
Brugia malayi PHD-finger family protein 0.0032 0.0065 0.0062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0295 0.0292
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0074 0.0071
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0127 0.1139
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0023 0.201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0023 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0068 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Brugia malayi hypothetical protein 0.0018 0.0018 0.0016
Leishmania major hypothetical protein, conserved 0.0017 0.0018 0.0798
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0068 0.0065
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0013 0.0103
Schistosoma mansoni deleted in oral cancer 1/cdk2-associated protein-like 0.0304 0.0915 0.0912
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0013 0.0113
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0013 0.0003 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0024 0.0021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.0491 0.2
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0034 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Schistosoma mansoni lipoxygenase 0.0135 0.0384 0.0382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0127 0.0124
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0023 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Echinococcus multilocularis geminin 0.0367 0.1112 0.4527
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0068 0.0065
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0013 0.0113
Brugia malayi steroid hormone receptor 0.0033 0.0068 0.0065
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0018 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Schistosoma mansoni lipoxygenase 0.0094 0.0258 0.0255
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0044 0.0041
Brugia malayi hypothetical protein 0.0016 0.0013 0.001
Brugia malayi Cathepsin L-like precursor 0.0019 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0013 0.0051
Echinococcus granulosus histone acetyltransferase KAT2B 0.0052 0.0124 0.1119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0068 0.0065
Onchocerca volvulus 0.0019 0.0023 0.0217
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0024 0.0217
Loa Loa (eye worm) voltage-dependent calcium channel 0.0024 0.0039 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0023 0.0298
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0013 0.0051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0068 0.0276
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0024 0.0217
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0044 0.0393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0068 0.0065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0068 0.0276
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0097
Onchocerca volvulus 0.0033 0.0068 0.0709
Loa Loa (eye worm) calcium channel 0.0116 0.0326 0.0324
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0068 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0177 0.0518 0.0515
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0016
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0052 0.0124 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0052 0.0124 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0018 0.0016
Echinococcus multilocularis voltage dependent calcium channel 0.0116 0.0326 0.1329
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0135 0.0384 0.1566
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0023 0.1977
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Schistosoma mansoni loxhd1 0.0023 0.0034 0.0031
Brugia malayi nuclear receptor RXR 0.0018 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0031
Schistosoma mansoni zinc finger protein 0.0026 0.0046 0.0043
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0023 0.1072
Echinococcus multilocularis sodium channel protein 0.0049 0.0117 0.0477
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0068 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Echinococcus multilocularis zinc finger protein 0.0026 0.0046 0.0187
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0027
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0034 0.0302
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0023 0.201
Schistosoma mansoni hypothetical protein 0.0023 0.0034 0.0031
Schistosoma mansoni nuclear receptor 0.0016 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0013 0.0113
Echinococcus granulosus RUN 0.0023 0.0034 0.0302
Echinococcus granulosus GPCR family 2 0.0034 0.0068 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0018 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0068 0.0611
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.0405 0.0403
Brugia malayi Cathepsin L-like precursor 0.0019 0.0023 0.002
Brugia malayi MH2 domain containing protein 0.0141 0.0405 0.0403
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0092 0.0373
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0189 0.1702
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0116 0.0326 0.2936
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0179 0.0523 0.052
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0023 0.0217
Loa Loa (eye worm) hypothetical protein 0.0053 0.0128 0.0125
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.0491 0.0488
Echinococcus granulosus cGMP dependent protein kinase 1 0.0013 0.0003 0.0025
Brugia malayi Cathepsin L-like precursor 0.0019 0.0023 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0013 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0127 0.0124
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0103 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0024 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.0052 0.0124 1
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0065
Echinococcus granulosus geminin 0.0367 0.1112 1
Onchocerca volvulus 0.0019 0.0023 0.0217
Onchocerca volvulus 0.0019 0.0023 0.0217
Loa Loa (eye worm) DR-78 0.0016 0.0013 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0024 0.0098
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0023 0.1977
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0068 0.0709
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0013 0.001
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0068 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0191 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0068 0.0278
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0034 0.0302
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0031
Entamoeba histolytica hypothetical protein 0.0035 0.0074 0.7055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0295 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0023 0.0094
Onchocerca volvulus 0.0023 0.0034 0.0333
Leishmania major cathepsin L-like protease 0.0019 0.0023 0.1072
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.0468 0.4211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0068 0.0613
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0023 0.1632
Onchocerca volvulus 0.0019 0.0023 0.0217
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0013 0.0051
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0068 0.0276
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0103 0.5
Schistosoma mansoni nuclear receptor 0.0016 0.0013 0.001
Leishmania major cathepsin L-like protease 0.0073 0.0191 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0127 0.0124
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0013 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0035 0.0074 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0068 0.0065
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0068 0.0065
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0023 0.1632
Onchocerca volvulus Diphthamide biosynthesis protein 7 homolog 0.0304 0.0915 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.0915 0.0912
Entamoeba histolytica hypothetical protein 0.0035 0.0074 0.7055
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0013 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Leishmania major cathepsin L-like protease 0.0073 0.0191 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0092 0.0823
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0013 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0013 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0191 1
Schistosoma mansoni zinc finger protein 0.0017 0.0018 0.0015
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0034 0.0137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0068 0.0276
Schistosoma mansoni hypothetical protein 0.0367 0.1112 0.1109
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0065
Onchocerca volvulus 0.0016 0.0013 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0068 0.0065

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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