Detailed information for compound 863539

Basic information

Technical information
  • TDR Targets ID: 863539
  • Name: 5-[(4-methylphenyl)sulfinylmethyl]-N-(2-thiop hen-2-ylethyl)furan-2-carboxamide
  • MW: 373.489 | Formula: C19H19NO3S2
  • H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)Cc1ccc(o1)C(=O)NCCc1cccs1
  • InChi: 1S/C19H19NO3S2/c1-14-4-7-17(8-5-14)25(22)13-15-6-9-18(23-15)19(21)20-11-10-16-3-2-12-24-16/h2-9,12H,10-11,13H2,1H3,(H,20,21)
  • InChiKey: OLYPQCJMQJNVQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4-methylphenyl)sulfinylmethyl]-N-[2-(2-thienyl)ethyl]furan-2-carboxamide
  • 5-[(4-methylphenyl)sulfinylmethyl]-N-[2-(2-thienyl)ethyl]-2-furancarboxamide
  • 5-[(4-methylphenyl)sulfinylmethyl]-N-[2-(2-thienyl)ethyl]-2-furamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0119 0.0769 0.2176
Echinococcus multilocularis vesicular acetylcholine transporter 0.0481 0.3327 0.942
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0769 0.4263
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0165 0.1132
Schistosoma mansoni myst-related protein 0.0011 0.0006 0.0016
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0146 0.0003
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0219 0.1477 0.6252
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0177 0.05
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0076 0.038
Toxoplasma gondii exonuclease III APE 0.0021 0.0076 0.0643
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0177
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0342 0.235 0.235
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.01 0.0301
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0235 0.0922
Echinococcus multilocularis heat shock protein 90 0.0039 0.0208 0.059
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0119 0.1021
Entamoeba histolytica peptidase, C54 family 0.0119 0.0769 0.3183
Echinococcus multilocularis survival motor neuron protein 1 0.0254 0.1724 0.4881
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0043 0.0235 1
Onchocerca volvulus 0.0342 0.235 0.224
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0168 0.0476
Schistosoma mansoni survival motor neuron protein 0.0052 0.0296 0.0837
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0177 0.05
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.1028 0.309
Onchocerca volvulus 0.0342 0.235 0.224
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0188 0.0532
Toxoplasma gondii heat shock protein 90, putative 0.0046 0.0255 0.2154
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0143 0.0404
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0481 0.3327 0.323
Plasmodium vivax endoplasmin, putative 0.0046 0.0255 0.1926
Brugia malayi vesicular acetylcholine transporter unc-17 0.0481 0.3327 1
Echinococcus granulosus heat shock protein 90 0.0046 0.0255 0.0723
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0639
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.021 0.0595
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0143 0.1204
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0165 0.0468
Schistosoma mansoni hypothetical protein 0.0297 0.2032 0.5753
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0146 0.0414
Entamoeba histolytica hypothetical protein 0.004 0.021 0.0854
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.008 0.0683
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0074 0.023
Brugia malayi Pre-SET motif family protein 0.0035 0.0177 0.0531
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0189 0.1016
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0177 0.05
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0177 0.05
Toxoplasma gondii Hsp90 domain-containing protein 0.0175 0.1165 0.982
Schistosoma mansoni hypothetical protein 0.0049 0.0277 0.0784
Echinococcus multilocularis endoplasmin 0.0043 0.0235 0.0667
Plasmodium vivax heat shock protein, putative 0.0175 0.1165 1
Schistosoma mansoni vesicular acetylcholine transporter 0.0481 0.3327 0.942
Plasmodium falciparum phd finger protein, putative 0.003 0.0143 0.1226
Trypanosoma cruzi lanosterol synthase, putative 0.0198 0.1332 0.5628
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0189 0.7092
Brugia malayi hypothetical protein 0.0254 0.1724 0.5182
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0143 0.0404
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0031 0.0087
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.031
Schistosoma mansoni hypothetical protein 0.003 0.0143 0.0404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0165 0.0468
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0146 0.0414
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0074 0.0211
Onchocerca volvulus Phospholipase A2 homolog 0.1425 1 1
Plasmodium vivax heat shock protein 86, putative 0.0046 0.0255 0.1926
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0132 0.0862 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0628 0.1779
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0208 0.0867
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0255 0.1008
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0831 0.2352
Giardia lamblia Grp94/Hsp90 0.0043 0.0235 0.098
Entamoeba histolytica hypothetical protein 0.004 0.021 0.0854
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0076 0.038
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0208 0.1123
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Schistosoma mansoni myst-related protein 0.0011 0.0006 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0189 0.1016
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0208 0.0805
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0098 0.0278
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0575 0.0575
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0217 0.186
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0126 0.0454
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0243 0.1814
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0119 0.0622
Schistosoma mansoni importin beta-1 0.0028 0.0126 0.0358
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.0143
Echinococcus granulosus heat shock protein 0.0046 0.0255 0.0723
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0076 0.038
Entamoeba histolytica peptidase, C54 family 0.0046 0.0257 0.1048
Entamoeba histolytica peptidase, C54 family 0.0046 0.0257 0.1048
Brugia malayi jmjC domain containing protein 0.0042 0.0224 0.0675
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.2032 0.2032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0165 0.0468
Brugia malayi Phospholipase A2 family protein 0.0375 0.2579 0.7751
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0076 0.038
Brugia malayi jmjC domain containing protein 0.0099 0.0628 0.1888
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0138 0.0138
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0255 0.1063
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0303 0.2605
Schistosoma mansoni hypothetical protein 0.0049 0.0277 0.0784
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0165 0.0468
Schistosoma mansoni inositol monophosphatase 0.0037 0.0189 0.0536
Onchocerca volvulus 0.0137 0.0898 0.0766
Loa Loa (eye worm) RNA binding protein 0.0127 0.0831 0.0831
Echinococcus multilocularis heat shock protein 0.0046 0.0255 0.0723
Loa Loa (eye worm) heat shock protein 90 0.0046 0.0255 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0046 0.0257 0.1013
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0165 0.062
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0205 0.0616
Entamoeba histolytica hypothetical protein 0.004 0.021 0.0854
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0165 0.1393
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0224 0.0224
Echinococcus multilocularis Peptidase C54 0.0119 0.0769 0.2176
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0303 0.2352
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0723
Loa Loa (eye worm) hypothetical protein 0.0122 0.0789 0.0789
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0076 0.0655
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0076 0.0318
Echinococcus multilocularis peregrin 0.0034 0.0169 0.0478
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0165 0.1393
Brugia malayi CXXC zinc finger family protein 0.0091 0.0575 0.1727
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0074 0.0628
Loa Loa (eye worm) inositol-1 0.0037 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.01 0.0633 0.2618
Entamoeba histolytica hypothetical protein 0.0023 0.0089 0.0349
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0076 0.0216
Trypanosoma brucei heat shock protein, putative 0.0046 0.0255 0.1008
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0107 0.0684 0.2055
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0243 0.2047
Trypanosoma brucei heat shock protein, putative 0.0046 0.0255 0.1008
Schistosoma mansoni hypothetical protein 0.0052 0.0296 0.0837
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0076 0.0238
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0769 0.4263
Echinococcus multilocularis bloom syndrome protein 0.0024 0.01 0.0284
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0098 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0177 0.05
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.01 0.0633 0.2618
Trichomonas vaginalis ran, putative 0.0021 0.0074 0.0373
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Entamoeba histolytica hypothetical protein 0.004 0.021 0.0854
Trypanosoma cruzi lanosterol synthase, putative 0.0198 0.1332 0.5628
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0277 0.0784
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.1186 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0126 0.0454
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0146 0.1231
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0165 0.062
Plasmodium falciparum cysteine protease ATG4, putative 0.0046 0.0257 0.2204
Trypanosoma cruzi phospholipase A1, putative 0.0342 0.235 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0143 0.0404
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0046 0.0257 0.1013
Schistosoma mansoni hypothetical protein 0.0049 0.0277 0.0784
Schistosoma mansoni cpg binding protein 0.0096 0.0611 0.1731
Echinococcus granulosus vesicular acetylcholine transporter 0.0481 0.3327 0.942
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0189 0.7092
Loa Loa (eye worm) RecQ helicase 0.0024 0.01 0.01
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0098 0.0278
Entamoeba histolytica Ran family GTPase 0.0021 0.0074 0.0287
Schistosoma mansoni ap endonuclease 0.0021 0.0076 0.0216
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0165 0.1124
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0074 0.0211
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0277 0.0784
Loa Loa (eye worm) hypothetical protein 0.0254 0.1724 0.1724
Brugia malayi PHD-finger family protein 0.003 0.0143 0.0429
Brugia malayi PHD-finger family protein 0.0015 0.0036 0.0108
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0074 0.023
Trypanosoma brucei heat shock protein, putative 0.0046 0.0255 0.1008
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0831 0.2352
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0226 0.0641
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.0898 0.3767
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0226 0.0641
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0021 0.0063
Trichomonas vaginalis helicase, putative 0.0021 0.0076 0.038
Brugia malayi Peptidase family C54 containing protein 0.0119 0.0769 0.231
Onchocerca volvulus 0.0264 0.1792 0.1673
Brugia malayi isocitrate dehydrogenase 0.0033 0.0165 0.0497
Echinococcus granulosus cpg binding protein 0.0096 0.0611 0.1731
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0295 0.0295
Schistosoma mansoni ran 0.0021 0.0074 0.0211
Plasmodium vivax importin-beta 2, putative 0.0028 0.0126 0.078
Plasmodium falciparum importin beta, putative 0.0028 0.0126 0.1085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0224 0.0636
Schistosoma mansoni transcription factor LCR-F1 0.004 0.021 0.0595
Schistosoma mansoni hypothetical protein 0.0049 0.0277 0.0784
Onchocerca volvulus 0.0342 0.235 0.224
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0769 0.4263
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0831 0.2352
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0995 0.2817
Brugia malayi heat shock protein 90 0.0046 0.0255 0.0768
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0255 0.1008
Echinococcus multilocularis cysteine protease atg4b 0.0119 0.0769 0.2176
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0243 0.1316
Echinococcus multilocularis GPCR, family 2 0.0049 0.0277 0.0784
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0277 0.0277
Echinococcus granulosus heat shock protein 90 0.0039 0.0208 0.059
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.0898 0.3767
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0303 0.1213
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0481 0.3327 0.3327
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Echinococcus multilocularis dnaJ subfamily B 0.0452 0.3122 0.884
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0046 0.0257 0.2164
Echinococcus granulosus geminin 0.051 0.3532 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0074 0.0319
Brugia malayi RNA binding protein 0.0127 0.0831 0.2497
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0166 0.0886
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0769 0.321
Leishmania major sterol 24-c-methyltransferase, putative 0.0219 0.1477 0.6252
Brugia malayi Endoplasmin precursor 0.0046 0.0255 0.0768
Echinococcus granulosus dnaJ subfamily B 0.0452 0.3122 0.884
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0035 0.0099
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.0208 0.059
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0189 0.0766
Echinococcus multilocularis cpg binding protein 0.0096 0.0611 0.1731
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0064 0.0182
Trypanosoma brucei Sterol methyltransferase, putative 0.0219 0.1477 0.6252
Echinococcus granulosus endoplasmin 0.0043 0.0235 0.0667
Plasmodium falciparum heat shock protein 90, putative 0.0175 0.1165 1
Trypanosoma brucei Heat shock protein 83, putative 0.0046 0.0255 0.1008
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0189 0.1595
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0089 0.0455
Trichomonas vaginalis set domain proteins, putative 0.0264 0.1792 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0303 0.2605
Loa Loa (eye worm) acetyltransferase 0.0151 0.0995 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0076 0.0295
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Onchocerca volvulus 0.0052 0.0296 0.0155
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0138 0.039
Trypanosoma brucei heat shock protein, putative 0.0046 0.0255 0.1008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.021 0.0595
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0219 0.1477 0.6252
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0157 0.104 0.4374
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0723
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0089 0.0455
Schistosoma mansoni heat shock protein 0.0046 0.0255 0.0723
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0303 0.1213
Brugia malayi Pre-SET motif family protein 0.0232 0.1568 0.4713
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0076 0.038
Plasmodium vivax hypothetical protein, conserved 0.003 0.0143 0.0926
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0126 0.1066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0024 0.0097 0.0275
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0076 0.0216
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0074 0.023
Echinococcus granulosus Peptidase C54 0.0119 0.0769 0.2176
Loa Loa (eye worm) endoplasmin 0.0046 0.0255 0.0255
Entamoeba histolytica peptidase, C54 family 0.0046 0.0257 0.1048
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Loa Loa (eye worm) hypothetical protein 0.0375 0.2579 0.2579
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.035 0.2403 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0177 0.05
Leishmania major hypothetical protein, conserved 0.0053 0.0303 0.1213
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0146 0.0538
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0045 0.0057
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0154 0.0436
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0208 0.0805
Leishmania major lanosterol synthase, putative 0.0198 0.1332 0.5628
Schistosoma mansoni autophagin-1 (C54 family) 0.0119 0.0769 0.2176
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0165 0.0497
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0015 0.0039 0.0331
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0177 0.1489
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0089 0.0455
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0723
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0165 0.062
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0277 0.0833
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0831 0.2497
Schistosoma mansoni inositol monophosphatase 0.0037 0.0189 0.0536
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0157 0.104 0.4374
Loa Loa (eye worm) hypothetical protein 0.0049 0.0277 0.0277
Schistosoma mansoni ap endonuclease 0.0021 0.0076 0.0216
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0066 0.0194
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0485 0.1372
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0303 0.2558
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0076 0.0383
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0255 0.1042
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0277 0.0833
Leishmania major heat shock protein, putative 0.0031 0.0146 0.0538
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0255 0.1008
Onchocerca volvulus 0.0091 0.0575 0.0438
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0195 0.1306 0.3699
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0831 0.0831
Plasmodium falciparum heat shock protein 90 0.0046 0.0255 0.2193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0217 0.0881
Trypanosoma brucei heat shock protein, putative 0.0046 0.0255 0.1008
Schistosoma mansoni heat shock protein 0.0031 0.0146 0.0414
Echinococcus granulosus importin subunit beta 1 0.0028 0.0126 0.0358
Schistosoma mansoni hypothetical protein 0.051 0.3532 1
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0342 0.235 0.7065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0277 0.0784
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0177 0.05
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0166 0.0886
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0995 0.2991
Echinococcus granulosus survival motor neuron protein 1 0.0254 0.1724 0.4881
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0076 0.0238
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0165 0.062
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.068 0.2045
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0126 0.0358
Brugia malayi Hsp90 protein 0.0031 0.0146 0.0439
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0076 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0146 0.0146
Echinococcus granulosus snurportin 1 0.0297 0.2032 0.5753
Leishmania major GTP-binding protein, putative 0.0021 0.0074 0.023
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0831 0.2352
Brugia malayi RNA, U transporter 1 0.0079 0.0489 0.1471
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0219 0.1477 0.6252
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0243 0.2047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0076 0.0238
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Trypanosoma cruzi Heat shock protein 83, putative 0.0046 0.0255 0.1008
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0162 0.1091
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0097 0.0275
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0255 0.1387
Onchocerca volvulus Phospholipase A2 homolog 0.0375 0.2579 0.2471
Loa Loa (eye worm) hypothetical protein 0.0053 0.0303 0.0303
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0255 0.1008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0008 0.00000000016289
Echinococcus multilocularis heat shock protein 90 0.0046 0.0255 0.0723
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0255 0.1008
Trypanosoma cruzi Emopamil binding protein, putative 0.0137 0.0898 0.3767
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0769 0.4263
Schistosoma mansoni hypothetical protein 0.0452 0.3122 0.884
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0076 0.038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.1568 0.1568
Schistosoma mansoni cpg binding protein 0.0091 0.0575 0.1627
Trypanosoma brucei heat shock protein, putative 0.0046 0.0255 0.1008
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0046 0.0257 0.1013
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0097 0.0275
Trypanosoma brucei phospholipase A1, putative 0.0342 0.235 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0165 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0831 0.2352
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0046 0.0257 0.1013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.1028 0.1028
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0146 0.0586
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0165 0.0468
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0044 0.0368
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0076 0.038
Treponema pallidum heat shock protein 90 0.0043 0.0235 1
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.0898 0.3767
Trypanosoma brucei Emopamil binding protein, putative 0.0137 0.0898 0.3767
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.037 0.037
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0165 0.1418
Trypanosoma cruzi Emopamil binding protein, putative 0.0137 0.0898 0.3767
Loa Loa (eye worm) hypothetical protein 0.0107 0.0684 0.0684
Toxoplasma gondii heat shock protein HSP90 0.0046 0.0255 0.2154
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Giardia lamblia DNA repair protein RAD52 0.035 0.2403 1
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0303 0.1213
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0143 0.0143
Entamoeba histolytica peptidase, C54 family 0.0046 0.0257 0.1048
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0098 0.0278
Echinococcus granulosus tar DNA binding protein 0.0127 0.0831 0.2352
Trypanosoma brucei lanosterol synthase 0.0198 0.1332 0.5628
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0628 0.1779
Schistosoma mansoni endoplasmin 0.0046 0.0255 0.0723
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0189 0.0536
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.1028 0.309
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0146 0.0954
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0235 0.1275
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0224
Schistosoma mansoni hypothetical protein 0.004 0.021 0.0595
Schistosoma mansoni hypothetical protein 0.0106 0.068 0.1926
Trypanosoma brucei heat shock protein, putative 0.0046 0.0255 0.1008
Brugia malayi Inositol-1 0.0037 0.0189 0.0569
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0769 0.321
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.01 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Loa Loa (eye worm) hypothetical protein 0.0155 0.1028 0.1028
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0089 0.0294
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0277 0.0784
Echinococcus multilocularis snurportin 1 0.0297 0.2032 0.5753
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0119 0.0769 0.2176
Loa Loa (eye worm) hypothetical protein 0.0106 0.068 0.068
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0296 0.0888
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0217 0.0902
Onchocerca volvulus 0.0035 0.0177 0.0034
Leishmania major sterol 24-c-methyltransferase, putative 0.0219 0.1477 0.6252
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0035 0.0099
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0769 0.4263
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0965 0.2733
Loa Loa (eye worm) hypothetical protein 0.0119 0.0769 0.0769
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0165 0.0468
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Brugia malayi TAR-binding protein 0.0127 0.0831 0.2497
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0114 0.0737 0.3073
Brugia malayi Importin beta-1 subunit 0.0028 0.0126 0.038
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0189 0.0723
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0189 0.0536
Leishmania major hypothetical protein, conserved 0.0137 0.0898 0.3767
Plasmodium vivax SET domain protein, putative 0.0035 0.0177 0.1226
Brugia malayi Bromodomain containing protein 0.0034 0.0169 0.0508
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0224 0.0636
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0235 0.2026
Echinococcus granulosus cysteine protease atg4b 0.0119 0.0769 0.2176
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0076 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0831 0.2352
Giardia lamblia PHD finger protein 15 0.003 0.0143 0.0594
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0134 0.0134
Echinococcus granulosus GPCR family 2 0.0049 0.0277 0.0784
Schistosoma mansoni heat shock protein 0.0046 0.0255 0.0723
Echinococcus granulosus bloom syndrome protein 0.0024 0.01 0.0284
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0235 1
Echinococcus multilocularis geminin 0.051 0.3532 1
Plasmodium falciparum zinc finger protein, putative 0.0011 0.0006 0.0048
Leishmania major importin beta-1 subunit, putative 0.0023 0.0089 0.0294
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0021 0.0072
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0224 0.0636
Plasmodium falciparum endoplasmin, putative 0.0033 0.0166 0.1426
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0235 0.1275
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0165 0.062
Brugia malayi Cytochrome P450 family protein 0.0029 0.0134 0.0402
Brugia malayi hypothetical protein 0.0034 0.0171 0.0514
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0043 0.0235 1
Brugia malayi hypothetical protein 0.0053 0.0303 0.0912
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0143 0.1204
Schistosoma mansoni cpg binding protein 0.0096 0.0611 0.1731
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.01 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0138 0.039
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0831 0.0831
Schistosoma mansoni endoplasmin 0.0046 0.0255 0.0723
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0243 0.0688
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0255 0.1042
Schistosoma mansoni hypothetical protein 0.051 0.3532 1
Schistosoma mansoni ran 0.0021 0.0074 0.0211
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0189 0.1016
Brugia malayi hypothetical protein 0.004 0.021 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0995 0.2817
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0219 0.1477 0.6252
Leishmania major heat shock protein 83-1 0.0046 0.0255 0.1008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0243 0.1316
Echinococcus granulosus peregrin 0.0034 0.0169 0.0478
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0255 0.1008
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0165 0.0468
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0219 0.1477 0.6252
Leishmania major phospholipase A1, putative 0.0342 0.235 1
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0146 0.0538
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0769 0.321
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0076 0.0076
Trypanosoma cruzi phospholipase A1, putative 0.0342 0.235 1
Trypanosoma brucei heat shock protein, putative 0.0046 0.0255 0.1008
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0076 0.0383
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0076 0.0229
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0076 0.0238

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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