Detailed information for compound 87198

Basic information

Technical information
  • TDR Targets ID: 87198
  • Name: 8-methoxy-2,2,4-trimethyl-1H-quinoline
  • MW: 203.28 | Formula: C13H17NO
  • H donors: 1 H acceptors: 0 LogP: 2.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1NC(C)(C)C=C2C
  • InChi: 1S/C13H17NO/c1-9-8-13(2,3)14-12-10(9)6-5-7-11(12)15-4/h5-8,14H,1-4H3
  • InChiKey: KRUCENDXMOILSL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • A2843/0119957
  • Oprea1_164957
  • ZINC04035939
  • ChemDiv2_002318
  • 8-Methoxy-2,2,4-trimethyl-1,2-dihydro-quinoline
  • Methyl 2,2,4-trimethyl-1,2-dihydro-8-quinolinyl ether

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0038 0.0019 0.0022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0063 0.0183 0.0177
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0038 0.0019 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0183 0.0436
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0183 0.0321
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus serotonin receptor 0.0063 0.0183 0.0436
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0038 0.0019 0.0022
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0621 0.3756 0.9249
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0048 0.0086 0.0104
Onchocerca volvulus 0.0063 0.0183 0.0751
Onchocerca volvulus 0.0063 0.0183 0.0751
Echinococcus multilocularis serotonin receptor 0.0063 0.0183 0.0177
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0038 0.0019 0.0022
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0076 1
Brugia malayi ORL1-like opioid receptor 0.0063 0.0183 0.047
Leishmania major cytochrome p450-like protein 0.0048 0.0086 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0061 0.0133
Echinococcus granulosus tar DNA binding protein 0.0063 0.0182 0.0433
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0076 0.0068
Onchocerca volvulus 0.0063 0.0183 0.0751
Loa Loa (eye worm) cytochrome P450 0.0038 0.0019 0.0033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0061 0.0106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0777 0.0931
Echinococcus granulosus somatostatin receptor 0.0063 0.0183 0.0436
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.138 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0038 0.0019 0.0022
Echinococcus multilocularis orexin receptor type 2 0.0063 0.0183 0.0177
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0063 0.0183 0.0435
Echinococcus multilocularis G protein coupled receptor 139 0.0063 0.0183 0.0177
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0038 0.0019 0.0022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0183 0.0435
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0621 0.3756 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0183 0.0436
Echinococcus multilocularis sex peptide receptor 0.0063 0.0183 0.0177
Onchocerca volvulus 0.0063 0.0183 0.0751
Onchocerca volvulus 0.0063 0.0183 0.0751
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0087
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0063 0.0183 0.047
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0038 0.0019 0.0022
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0038 0.0019 0.0022
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0612 0.3697 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0076 0.0091
Echinococcus granulosus g-protein coupled receptor 0.0063 0.0183 0.0436
Onchocerca volvulus 0.0063 0.0183 0.0751
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Brugia malayi GnHR receptor homolog 0.0063 0.0183 0.047
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0065
Brugia malayi Melatonin receptor type 1A 0.0063 0.0183 0.047
Mycobacterium ulcerans TetR family transcriptional regulator 0.1337 0.8346 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0209 0.0538
Schistosoma mansoni opsin-like receptor 0.0063 0.0183 0.0435
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0038 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0183 0.0436
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0038 0.0019 0.0022
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0183 0.0321
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Brugia malayi G protein-coupled receptor 0.0063 0.0183 0.047
Echinococcus granulosus 7tm_1 domain containing protein 0.0063 0.0183 0.0436
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0044 0.0067
Onchocerca volvulus 0.0063 0.0183 0.0751
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0038 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0067 0.0209 0.0366
Echinococcus granulosus cytochrome P450 2K1 0.0038 0.0019 0.003
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Brugia malayi RNA binding protein 0.0063 0.0182 0.0467
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0183 0.0177
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Echinococcus multilocularis 0.0038 0.0019 0.0012
Onchocerca volvulus 0.0063 0.0183 0.0751
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Schistosoma mansoni biogenic amine receptor 0.0063 0.0183 0.0435
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0063 0.0183 0.0321
Echinococcus granulosus neuropeptide receptor 0.0063 0.0183 0.0436
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0063 0.0183 0.0321
Schistosoma mansoni opsin-like receptor 0.0063 0.0183 0.0435
Echinococcus multilocularis neuropeptide receptor A26 0.0063 0.0183 0.0177
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0183 0.0321
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0183 0.0436
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0182 0.0467
Loa Loa (eye worm) hypothetical protein 0.0047 0.0076 0.0132
Schistosoma mansoni alpha-1 adrenergic receptor 0.0063 0.0183 0.0435
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Echinococcus granulosus fmrfamide receptor 0.0063 0.0183 0.0436
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0063 0.0183 0.047
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0063 0.0183 0.0436
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.028 0.1568 0.186
Echinococcus granulosus tachykinin peptides receptor 99D 0.0063 0.0183 0.0436
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0061 0.0133
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0044 0.0067
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Brugia malayi Cytochrome P450 family protein 0.0048 0.0086 0.0212
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.138 1
Brugia malayi G-protein coupled receptor 0.0063 0.0183 0.047
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Schistosoma mansoni amine GPCR 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0038 0.0019 0.0022
Onchocerca volvulus 0.0063 0.0183 0.0751
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0183 0.0177
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0063 0.0183 0.0435
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0061 0.0054
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.138 0.3663
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0182 0.0432
Echinococcus granulosus geminin 0.0333 0.1913 0.4703
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0621 0.3756 0.4501
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0063 0.0183 0.0435
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0409 0.1072
Brugia malayi Bromodomain containing protein 0.0075 0.0257 0.0666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Schistosoma mansoni biogenic amine receptor 0.0063 0.0183 0.0435
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0183 0.0436
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0409 0.0716
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Schistosoma mansoni hypothetical protein 0.0333 0.1913 0.4702
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0621 0.3756 0.4488
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus g protein coupled receptor 0.0063 0.0183 0.0436
Brugia malayi sulfakinin receptor protein 0.0063 0.0183 0.047
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0183 0.0177
Brugia malayi TAR-binding protein 0.0063 0.0182 0.0467
Brugia malayi Dopamine receptor protein 2 0.0063 0.0183 0.047
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0086 0.0181
Schistosoma mansoni neuropeptide receptor 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0119 0.0537 0.0941
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0183 0.0177
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0038 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0047 0.0076 0.0132
Onchocerca volvulus 0.0063 0.0183 0.0751
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0183 0.0177
Echinococcus granulosus hypothetical protein 0.0063 0.0183 0.0436
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0038 0.0019 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0063 0.0183 0.0177
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.138 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0076 0.0091
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.138 0.2417
Brugia malayi putative neuropeptide receptor NPR1 0.0063 0.0183 0.047
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0183 0.0177
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0183 0.0177
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0612 0.3697 0.443
Schistosoma mansoni amine GPCR 0.0063 0.0183 0.0435
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0183 0.0436
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0038 0.0019 0.0022
Brugia malayi GMP reductase 0.027 0.1509 0.4006
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0038 0.0019 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0061 0.0143
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0 0.5
Schistosoma mansoni opsin-like receptor 0.0063 0.0183 0.0435
Brugia malayi Serotonin receptor 0.0063 0.0183 0.047
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0621 0.3756 0.4501
Leishmania major inosine-5-monophosphate dehydrogenase 0.0621 0.3756 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0063 0.0183 0.0435
Schistosoma mansoni neuropeptide receptor 0.0063 0.0183 0.0435
Onchocerca volvulus Huntingtin homolog 0.0119 0.0537 0.3221
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0044 0.0067
Brugia malayi Bromodomain containing protein 0.0038 0.0022 0.004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0063 0.0183 0.0751
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0063 0.0183 0.0177
Loa Loa (eye worm) cytochrome P450 family protein 0.0128 0.0597 0.1046
Schistosoma mansoni hypothetical protein 0.0038 0.0019 0.0029
Schistosoma mansoni hypothetical protein 0.0067 0.0209 0.0498
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0183 0.0177
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.3756 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0182 0.0432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0183 0.0177
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0076 0.0183
Schistosoma mansoni hypothetical protein 0.0063 0.0183 0.0435
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0183 0.0435
Brugia malayi Dopamine receptor 0.0063 0.0183 0.047
Toxoplasma gondii hypothetical protein 0.0048 0.0083 0.0172
Echinococcus multilocularis neuropeptide s receptor 0.0063 0.0183 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0183 0.0177
Echinococcus granulosus dro:myosuppressin receptor 0.0063 0.0183 0.0436
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0183 0.0436
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0038 0.0019 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.1675 0.4432
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0063 0.0183 0.047
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0183 0.0436
Loa Loa (eye worm) RNA binding protein 0.0063 0.0182 0.0319
Trypanosoma cruzi GMP reductase 0.0621 0.3756 1
Brugia malayi Cytochrome P450 family protein 0.0048 0.0086 0.0212
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0885 0.1027
Schistosoma mansoni hypothetical protein 0.0063 0.0183 0.0435
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0076 0.0091
Toxoplasma gondii IMP dehydrogenas 0.0621 0.3756 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0183 0.0177
Onchocerca volvulus 0.0063 0.0183 0.0751
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0183 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0183 0.0177
Brugia malayi neuropeptide F receptor 0.0063 0.0183 0.047
Echinococcus granulosus G protein coupled receptor 139 0.0063 0.0183 0.0436
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Loa Loa (eye worm) IMP dehydrogenase 1 0.0621 0.3756 0.6577
Brugia malayi Cytochrome P450 family protein 0.0128 0.0597 0.1575
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0038 0.0019 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0038 0.0019 0.0022
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0342 0.1965 0.2337
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0038 0.0019 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0038 0.0019 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0183 0.0177
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0182 0.0432
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0086 0.0151
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0063 0.0183 0.0321
Brugia malayi neuropeptide F receptor 0.0063 0.0183 0.047
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0885 0.1027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0022 0.0039
Schistosoma mansoni amine GPCR 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus sex peptide receptor 0.0063 0.0183 0.0436
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.406 0.4056
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0063 0.0183 0.0321
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0038 0.0019 0.0022
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0038 0.0019 0.0022
Schistosoma mansoni cytochrome P450 0.0038 0.0019 0.0029
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0038 0.0019 0.0022
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1337 0.8346 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0183 0.0435
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0159 0.0152
Echinococcus granulosus 7TM GPCR rhodopsin 0.0063 0.0183 0.0436
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0076 0.0152
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0063 0.0183 0.047
Loa Loa (eye worm) hypothetical protein 0.0926 0.5711 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0076 0.0091
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0076 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0076 0.0091
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0063 0.0183 0.0177
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0038 0.0019 0.0022
Schistosoma mansoni hypothetical protein 0.0063 0.0183 0.0435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0061 0.0133
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0675 0.1757
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0183 0.0436
Echinococcus multilocularis g-protein coupled receptor 0.0063 0.0183 0.0177
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0063 0.0183 0.0436
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0675 0.1757
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0063 0.0183 0.0177
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0038 0.0019 0.0022
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.028 0.1568 0.1878
Brugia malayi putative neuropeptide receptor 0.0063 0.0183 0.047
Schistosoma mansoni amine GPCR 0.0063 0.0183 0.0435
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0038 0.0019 0.0022
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0621 0.3756 0.9249
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0612 0.3697 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0076 0.0091
Schistosoma mansoni hypothetical protein 0.0333 0.1913 0.4702
Schistosoma mansoni growth hormone secretagogue receptor 0.0063 0.0183 0.0435
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.027 0.1509 0.4006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Echinococcus granulosus allatostatin A receptor 0.0063 0.0183 0.0436
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0076 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0182 0.0432
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0063 0.0183 0.0177
Mycobacterium ulcerans transcriptional regulator 0.1337 0.8346 1
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0183 0.0436
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0342 0.1965 0.2355
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0086 0.0181
Brugia malayi larval opioid receptor 0.0063 0.0183 0.047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0076 1
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0829 0.5255
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0183 0.0435
Schistosoma mansoni neuropeptide receptor 0.0063 0.0183 0.0435
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0038 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus g protein coupled receptor 0.0063 0.0183 0.0436
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0183 0.0177
Loa Loa (eye worm) TYRA-2 protein 0.0063 0.0183 0.0321
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0159 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Echinococcus granulosus neuropeptide receptor A26 0.0063 0.0183 0.0436
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0183 0.0435
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0038 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0182 0.0319
Echinococcus granulosus neuropeptide FF receptor 2 0.0063 0.0183 0.0436
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0038 0.0019 0.0022
Mycobacterium ulcerans hypothetical protein 0.0156 0.0777 0.0931
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0063 0.0183 0.0436
Schistosoma mansoni adenoreceptor 0.0063 0.0183 0.0435
Onchocerca volvulus 0.0063 0.0183 0.0751
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0076 0.0091
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.3756 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.138 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.138 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0076 0.0091
Brugia malayi AKH receptor 0.0063 0.0183 0.047
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus orexin receptor type 2 0.0063 0.0183 0.0436
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0038 0.0019 0.0022
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.3756 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0063 0.0183 0.047
Loa Loa (eye worm) GMP reductase 0.027 0.1509 0.2642
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0183 0.0435
Schistosoma mansoni bromodomain containing protein 0.0063 0.0182 0.0431
Loa Loa (eye worm) hypothetical protein 0.0926 0.5711 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0038 0.0019 0.0022
Schistosoma mansoni myosin xvIII 0.0063 0.0183 0.0435
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0183 0.0436
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0038 0.0019 0.0022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0183 0.0436
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0038 0.0019 0.0022
Schistosoma mansoni neuropeptide f receptor 76f 0.0063 0.0183 0.0435
Leishmania major guanosine monophosphate reductase 0.0621 0.3756 1
Schistosoma mansoni amine GPCR 0.0063 0.0183 0.0435
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0063 0.0183 0.0177
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0102 0.0223
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0183 0.0436
Onchocerca volvulus 0.0063 0.0183 0.0751
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Brugia malayi G-protein coupled receptor 0.0063 0.0183 0.047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0119 0.0537 0.0941
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0063 0.0183 0.0177
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0038 0.0019 0.0022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0409 0.1072
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1337 0.8346 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.138 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0076 0.0132
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0063 0.0183 0.047
Schistosoma mansoni biogenic amine receptor 0.0063 0.0183 0.0435
Echinococcus granulosus g protein coupled receptor 0.0063 0.0183 0.0436
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0183 0.0177
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.1675 0.4432
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0183 0.0177
Loa Loa (eye worm) melatonin receptor type 1A 0.0063 0.0183 0.0321
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Brugia malayi RE15519p 0.0063 0.0183 0.047
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0038 0.0019 0.0022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0076 0.0068
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0076 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0076 0.0183
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus multilocularis geminin 0.0333 0.1913 0.1908
Trypanosoma cruzi GMP reductase 0.0621 0.3756 1
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0183 0.0436
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.406 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0621 0.3756 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0063 0.0183 0.0436
Onchocerca volvulus 0.0063 0.0183 0.0751
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0038 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus multilocularis allatostatin A receptor 0.0063 0.0183 0.0177
Brugia malayi Cytochrome P450 family protein 0.0038 0.0019 0.0031
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0063 0.0183 0.0751
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0061 0.0133
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0076 0.0152
Loa Loa (eye worm) hypothetical protein 0.0071 0.0229 0.0401
Onchocerca volvulus Huntingtin homolog 0.0119 0.0537 0.3221
Schistosoma mansoni neuropeptide receptor 0.0063 0.0183 0.0435
Brugia malayi hypothetical protein 0.0119 0.0537 0.1414
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.1675 0.4432
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0063 0.0183 0.0177
Echinococcus multilocularis dro:myosuppressin receptor 0.0063 0.0183 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0183 0.0177
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0038 0.0019 0.0022
Brugia malayi follicle stimulating hormone receptor 0.0063 0.0183 0.047
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0621 0.3756 0.3752
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0675 0.1757
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0086 0.0181
Onchocerca volvulus 0.0063 0.0183 0.0751
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0182 0.0176
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0183 0.0436
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0183 0.0436
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0063 0.0183 0.0435
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Echinococcus multilocularis serotonin receptor 0.0063 0.0183 0.0177
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0182 0.0432
Onchocerca volvulus 0.0063 0.0183 0.0751
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0086 0.0151
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0183 0.0435
Onchocerca volvulus 0.0063 0.0183 0.0751
Schistosoma mansoni hypothetical protein 0.0063 0.0183 0.0435
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0038 0.0019 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.0063 0.0183 0.0177
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0182 0.0319
Brugia malayi Serotonin receptor 0.0063 0.0183 0.047
Brugia malayi cytochrome P450 0.0038 0.0019 0.0031
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0183 0.0436
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0183 0.0177
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0183 0.0436
Echinococcus granulosus microtubule associated protein 2 0.0669 0.406 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.1675 0.4432
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0183 0.0436
Echinococcus granulosus neuropeptide receptor 0.0063 0.0183 0.0436
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0621 0.3756 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Schistosoma mansoni histamine h1 receptor 0.0063 0.0183 0.0435
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0183 0.0177
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0063 0.0183 0.0321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0007 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus neuropeptide s receptor 0.0063 0.0183 0.0436
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0063 0.0183 0.0435
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Brugia malayi Dopamine receptor protein 1 0.0063 0.0183 0.047
Trypanosoma brucei GMP reductase 0.0621 0.3756 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0183 0.0321
Brugia malayi G protein-coupled receptor F59B2.13 0.0063 0.0183 0.047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Echinococcus granulosus peptide allatostatin:somatostatin 0.0063 0.0183 0.0436
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0183 0.0177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Brugia malayi hypothetical protein 0.0063 0.0183 0.047
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0076 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0183 0.0177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0183 0.0435
Mycobacterium ulcerans hypothetical protein 0.0047 0.0076 0.0091
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0038 0.0019 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0061 0.0133
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0183 0.0177
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Loa Loa (eye worm) hypothetical protein 0.0063 0.0183 0.0321
Loa Loa (eye worm) hypothetical protein 0.0099 0.0409 0.0716
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1337 0.8346 1
Echinococcus multilocularis somatostatin receptor 0.0063 0.0183 0.0177
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0183 0.0177
Onchocerca volvulus Putative GMP reductase 0.027 0.1509 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0061 0.0054
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0183 0.0177
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0044 0.0067
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.027 0.1509 0.4006
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0086 0.0151

Activities

Activity type Activity value Assay description Source Reference
pKa = 3.36 Dissociation constant of compound at 20 degree C ChEMBL. 2666668

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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