Detailed information for compound 87278

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 545.611 | Formula: C24H31N7O6S
  • H donors: 3 H acceptors: 6 LogP: 0.6 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C(NS(=O)(=O)NCCc1cccc(c1)[N+](=O)[O-])Cc1cccc(c1)C(=N)N)N1CCN(CC1)C(=O)C
  • InChi: 1S/C24H31N7O6S/c1-17(32)29-10-12-30(13-11-29)24(33)22(16-19-5-2-6-20(14-19)23(25)26)28-38(36,37)27-9-8-18-4-3-7-21(15-18)31(34)35/h2-7,14-15,22,27-28H,8-13,16H2,1H3,(H3,25,26)
  • InChiKey: YFURVHHJGCZMTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipD 0.0144 0.0552 0.0584
Brugia malayi MH2 domain containing protein 0.0364 0.1507 0.8947
Toxoplasma gondii exonuclease III APE 0.0079 0.0267 0.3752
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0144 0.0282
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0415 0.0439
Brugia malayi hypothetical protein 0.0024 0.0029 0.0172
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0087 0.017
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0776 0.152
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0144 0.0552 0.0584
Mycobacterium leprae Probable lipase LipE 0.0144 0.0552 0.1942
Trichomonas vaginalis penicillin-binding protein, putative 0.0144 0.0552 0.0552
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0521 0.2183 0.4278
Mycobacterium ulcerans beta-lactamase 0.0144 0.0552 0.0552
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.01 0.0197
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0129 0.2592
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0513 0.3049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.014 0.0274
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0547
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.2195 0.9447 1
Trichomonas vaginalis DNA polymerase eta, putative 0.003 0.0055 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.1006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0144 0.0552 0.0584
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0117 0.0434 0.046
Echinococcus granulosus tar DNA binding protein 0.0196 0.0776 0.152
Schistosoma mansoni rab6-interacting 0.0024 0.0029 0.0057
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0007 0.0057
Schistosoma mansoni hypothetical protein 0.0024 0.0029 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.01 0.01
Brugia malayi RNA binding protein 0.0196 0.0776 0.4607
Echinococcus granulosus carbonic anhydrase 0.0181 0.0711 0.1394
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.0552 0.0552
Mycobacterium ulcerans lipase LipD 0.0144 0.0552 0.0552
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0181 0.0711 0.4224
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0129 0.0254
Brugia malayi Inositol-1 0.0036 0.0081 0.0482
Plasmodium falciparum carbonic anhydrase 0.0181 0.0711 1
Mycobacterium tuberculosis Probable reductase 0.0113 0.0415 0.0439
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.003 0.0055 0.0055
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0029 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0082 0.0281 0.1659
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0007 0.0014
Schistosoma mansoni DNA polymerase eta 0.0023 0.0027 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0077 0.0077
Trypanosoma brucei hypothetical protein, conserved 0.0144 0.0552 0.4381
Onchocerca volvulus 0.0144 0.0552 0.239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0077 0.0077
Echinococcus multilocularis endothelin converting enzyme 1 0.0117 0.0434 0.0851
Trichomonas vaginalis conserved hypothetical protein 0.2323 1 1
Onchocerca volvulus 0.0528 0.2217 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0129 0.1027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0088 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0267 0.0267
Loa Loa (eye worm) peptidase family M13 containing protein 0.0087 0.0301 0.1782
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0027 0.0053
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0059 0.0182 0.0357
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0456 0.0893
Loa Loa (eye worm) hypothetical protein 0.0087 0.0301 0.1782
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0308 0.126 0.7482
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0029 0.0408
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0033 0.0066
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0084 0.0291 0.0291
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0007 0.0057
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0081 0.1569
Loa Loa (eye worm) RNA binding protein 0.0196 0.0776 0.4601
Echinococcus multilocularis calpain 5 0.0019 0.0007 0.0014
Schistosoma mansoni carbonic anhydrase 0.0181 0.0711 0.1394
Brugia malayi Latrophilin receptor protein 2 0.005 0.0144 0.0853
Brugia malayi hypothetical protein 0.0037 0.0087 0.0515
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0081 0.0644
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0129 0.0769
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0084 0.0291 0.2308
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0163 0.2285
Loa Loa (eye worm) hypothetical protein 0.004 0.01 0.0586
Echinococcus granulosus dna polymerase eta 0.0023 0.0027 0.0053
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0144 0.0552 0.0584
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0144 0.0552 0.3271
Schistosoma mansoni lamin 0.0083 0.0287 0.0563
Mycobacterium tuberculosis Probable esterase LipL 0.0144 0.0552 0.0584
Toxoplasma gondii hypothetical protein 0.0181 0.0711 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0002 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0079 0.0267 0.1576
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0088 0.0698
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0776 0.152
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0118 0.0691
Loa Loa (eye worm) hypothetical protein 0.0144 0.0552 0.3271
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0199 0.0391
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0129 0.1027
Loa Loa (eye worm) hypothetical protein 0.0063 0.0199 0.1176
Leishmania major DNA polymerase kappa, putative 0.0025 0.0034 0.0269
Loa Loa (eye worm) hypothetical protein 0.0089 0.031 0.1834
Toxoplasma gondii peptidase family M13 protein 0.0117 0.0434 0.6103
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0308 0.126 0.748
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0415 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0036 0.0036
Schistosoma mansoni sodium-bile acid cotransporter related 0.0041 0.0105 0.0206
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0007 0.0057
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0144 0.0282
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0114
Loa Loa (eye worm) calpain 0.0019 0.0007 0.0032
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0079 0.0267 0.0267
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0163 0.129
Brugia malayi Sodium Bile acid symporter family protein 0.0102 0.0369 0.2189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0007 0.0057
Onchocerca volvulus Putative sulfate transporter 0.0528 0.2217 1
Leishmania major trypanothione reductase 0.0049 0.014 0.1112
Schistosoma mansoni carbonic anhydrase-related 0.0181 0.0711 0.1394
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.0711 0.4224
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0092 0.0324 0.0636
Onchocerca volvulus 0.0058 0.0178 0.0679
Schistosoma mansoni neprilysin-2 (M13 family) 0.0059 0.0182 0.0357
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0181 0.0711 0.4218
Echinococcus granulosus endothelin converting enzyme 1 0.0117 0.0434 0.0851
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0776 0.152
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0308 0.126 0.2469
Treponema pallidum exodeoxyribonuclease (exoA) 0.0079 0.0267 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0267 0.4835
Onchocerca volvulus 0.0044 0.0118 0.0407
Loa Loa (eye worm) hypothetical protein 0.0144 0.0552 0.3271
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0002 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0196 0.0776 0.4601
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0007 0.0014
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0007 0.0057
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0065 0.0069
Echinococcus granulosus lamin dm0 0.0083 0.0287 0.0563
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0007 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0084 0.0164
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0027 0.0149
Giardia lamblia DINP protein human, muc B family 0.0025 0.0034 0.1272
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0084 0.0291 0.4088
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0029 0.0162
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0002 0.0031
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0033 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Loa Loa (eye worm) hypothetical protein 0.0144 0.0552 0.3271
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0254 0.1028 0.61
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0079 0.0267 1
Mycobacterium leprae probable zinc metalloprotease 0.0117 0.0434 0.1472
Loa Loa (eye worm) hypothetical protein 0.0089 0.031 0.1834
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0117 0.0434 0.0851
Mycobacterium ulcerans esterase/lipase LipP 0.0144 0.0552 0.0552
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0456 0.0893
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0088 0.0698
Echinococcus multilocularis sodium bile acid cotransporter 0.0102 0.0369 0.0722
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0129 0.1027
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0031 0.0058 0.0114
Loa Loa (eye worm) hypothetical protein 0.0087 0.0301 0.1782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0047 0.0047
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0002 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0027 0.016
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0027 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.2323 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0088 0.0088
Brugia malayi calpain family protein 1 0.0063 0.0199 0.1185
Schistosoma mansoni loxhd1 0.0024 0.0029 0.0057
Echinococcus granulosus calpain 5 0.0019 0.0007 0.0014
Brugia malayi MH2 domain containing protein 0.0025 0.0033 0.0199
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0002 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0144 0.0552 0.1081
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0084 0.1178
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0029 0.0057
Mycobacterium ulcerans zinc metalloprotease 0.0117 0.0434 0.0434
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0163 0.2285
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0081 0.3042
Schistosoma mansoni lamin 0.0083 0.0287 0.0563
Schistosoma mansoni smad1 5 8 and 0.0025 0.0033 0.0066
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0178 0.0697 0.0697
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0162
Toxoplasma gondii ABC1 family protein 0.0144 0.0552 0.776
Brugia malayi jmjC domain containing protein 0.0024 0.0028 0.0169
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.0615 0.365
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0162
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0144 0.0282
Echinococcus granulosus lysine specific demethylase 5A 0.0024 0.0028 0.0056
Schistosoma mansoni hypothetical protein 0.0037 0.0087 0.017
Brugia malayi beta-lactamase family protein 0.0144 0.0552 0.3278
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0029 0.0057
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0029 0.005 0.0097
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.014 0.0822
Echinococcus multilocularis hypothetical protein 0.0019 0.0007 0.0014
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0017 0 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0364 0.1507 0.8946
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0415 0.0439
Brugia malayi isocitrate dehydrogenase 0.0018 0.0002 0.001
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0738 0.3125 0.3308
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0128 0.0479 0.165
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.2854 0.5593
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0129 0.0254
Chlamydia trachomatis sulfate transporter 0.0084 0.0291 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0057 0.0172 0.0336
Schistosoma mansoni endothelin-converting enzyme-related 0.0029 0.005 0.0097
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.01 0.0197
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0144 0.0282
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0034 0.0269
Echinococcus multilocularis geminin 0.1194 0.5104 1
Loa Loa (eye worm) zinc metallopeptidase 4 0.0029 0.005 0.0284
Echinococcus multilocularis sodium bile acid cotransporter 0.0102 0.0369 0.0722
Leishmania major carbonic anhydrase-like protein 0.0308 0.126 1
Schistosoma mansoni hypothetical protein 0.005 0.0144 0.0282
Echinococcus granulosus carbonic anhydrase 0.0181 0.0711 0.1394
Trypanosoma brucei kinesin, putative 0.0019 0.0007 0.0057
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0029 0.0057
Trypanosoma brucei trypanothione reductase 0.0049 0.014 0.1112
Echinococcus multilocularis dna polymerase eta 0.0023 0.0027 0.0053
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0415 0.0439
Trypanosoma brucei carbonic anhydrase-like protein 0.0308 0.126 1
Echinococcus multilocularis carbonic anhydrase 0.0181 0.0711 0.1394
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0055 0.044
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.0711 0.4224
Schistosoma mansoni Smad4 0.0025 0.0033 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0488
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0287 0.1699
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Schistosoma mansoni carbonic anhydrase 0.0128 0.0479 0.0938
Echinococcus granulosus sodium bile acid cotransporter 0.0102 0.0369 0.0722
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0776 0.152
Loa Loa (eye worm) hypothetical protein 0.0144 0.0552 0.3271
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.0776 0.4607
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0002 0.0014
Schistosoma mansoni ap endonuclease 0.0079 0.0267 0.0523
Loa Loa (eye worm) glutathione reductase 0.0049 0.014 0.0822
Echinococcus multilocularis dna polymerase kappa 0.003 0.0055 0.0109
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0027 0.0213
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0002 0.0014
Echinococcus multilocularis carbonic anhydrase 0.0181 0.0711 0.1394
Leishmania major kinesin, putative 0.0019 0.0007 0.0057
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0415 0.1395
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0003 0.002
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.014 0.1112
Loa Loa (eye worm) hypothetical protein 0.0087 0.0301 0.1782
Entamoeba histolytica carbonic anhydrase, putative 0.0128 0.0479 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0088 0.0088
Onchocerca volvulus 0.0144 0.0552 0.239
Loa Loa (eye worm) hypothetical protein 0.005 0.0144 0.0844
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0007 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0129 0.0129
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0007 0.0057
Mycobacterium leprae Probable transmembrane transport protein 0.061 0.2572 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0077 0.0077
Brugia malayi follicle stimulating hormone receptor 0.0225 0.0903 0.536
Brugia malayi acetyltransferase, GNAT family protein 0.0058 0.0179 0.1062
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0117 0.0434 0.2578
Echinococcus multilocularis lamin dm0 0.0083 0.0287 0.0563
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0287 0.1173 0.6961
Loa Loa (eye worm) Smad1 0.0025 0.0033 0.0189
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0087 0.017
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.014 0.0274
Loa Loa (eye worm) hypothetical protein 0.0089 0.031 0.1834
Onchocerca volvulus 0.0144 0.0552 0.239
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.012 0.071
Brugia malayi calpain 5 0.0019 0.0007 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0088 0.0088
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0002 0.0024
Schistosoma mansoni hypothetical protein 0.1194 0.5104 1
Echinococcus multilocularis carbonic anhydrase II 0.0308 0.126 0.2469
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0029 0.0057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0081 0.0644
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0397 0.2355
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0059 0.0182 0.0357
Echinococcus granulosus sodium bile acid cotransporter 0.0102 0.0369 0.0722
Trypanosoma cruzi hypothetical protein, conserved 0.0144 0.0552 0.4381
Onchocerca volvulus 0.0289 0.118 0.526
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0002 0.0014
Trichomonas vaginalis set domain proteins, putative 0.0289 0.118 0.118
Echinococcus multilocularis smad 0.0025 0.0033 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0002 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0055 0.0055
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0163 0.2945
Schistosoma mansoni neprilysin 0.0031 0.0058 0.0114
Echinococcus multilocularis carbonic anhydrase 0.0181 0.0711 0.1394
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0007 0.0014
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0469 0.0497
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0084 0.0164
Echinococcus granulosus intermediate filament protein 0.0083 0.0287 0.0563
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.014 0.2537
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0469 0.0497
Trypanosoma brucei unspecified product 0.0028 0.0048 0.0383
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0032 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0077 0.0077
Brugia malayi Peptidase family M13 containing protein 0.0117 0.0434 0.2578
Echinococcus granulosus tumor protein p63 0.1057 0.4509 0.8835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.1006
Loa Loa (eye worm) hypothetical protein 0.0055 0.0163 0.0956
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.0552 0.0552
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0002 0.0014
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0267 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0077 0.0077
Echinococcus granulosus smad 0.0025 0.0033 0.0066
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0308 0.126 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0308 0.126 0.748
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0079 0.0267 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0047 0.0047
Brugia malayi beta-lactamase 0.0144 0.0552 0.3278
Schistosoma mansoni jumonji/arid domain-containing protein 0.0024 0.0028 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0084 0.0164
Trypanosoma brucei DNA polymerase IV, putative 0.0028 0.0048 0.0383
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0144 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0117 0.0434 0.2571
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0513 0.1006
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0081 0.1141
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0084 0.0291 0.0291
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0078 0.0153
Echinococcus granulosus GPCR family 2 0.005 0.0144 0.0282
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0081 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0003 0.002
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.061 0.2572 0.2723
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0213 0.0418
Loa Loa (eye worm) peptidase family M13 containing protein 0.0087 0.0301 0.1782
Echinococcus granulosus RUN 0.0024 0.0029 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0003 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0002 0.0003
Brugia malayi TAR-binding protein 0.0196 0.0776 0.4607
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0007 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0087 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0007 0.0057
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0058 0.0179 0.035
Brugia malayi MH1 domain containing protein 0.0025 0.0033 0.0199
Schistosoma mansoni carbonic anhydrase-related 0.0181 0.0711 0.1394
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0007 0.0057
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0415 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0036 0.0036
Brugia malayi beta-lactamase family protein 0.0144 0.0552 0.3278
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0129 0.0759
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0144 0.0552 0.3278
Mycobacterium ulcerans carbonic anhydrase 0.0128 0.0479 0.0479
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0144 0.0844
Schistosoma mansoni sodium-bile acid cotransporter 0.0061 0.0189 0.037
Echinococcus granulosus Smad4 0.0025 0.0033 0.0066
Brugia malayi Thioredoxin reductase 0.0049 0.014 0.0832
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0084 0.0291 0.2308
Brugia malayi jmjC domain containing protein 0.0024 0.0028 0.0169
Loa Loa (eye worm) hypothetical protein 0.0117 0.0434 0.2571
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.001 0.0082
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0129 0.1027
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0081 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0144 0.0552 0.3271
Schistosoma mansoni inositol monophosphatase 0.0036 0.0081 0.0159
Echinococcus granulosus carbonic anhydrase 0.0181 0.0711 0.1394
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0007 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0055 0.044
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0277 0.1125 0.2205
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0034 0.0269
Brugia malayi hypothetical protein 0.0055 0.0163 0.0965
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0469 0.1612
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0084 0.0164
Brugia malayi glutathione reductase 0.0049 0.014 0.0832
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0084 0.0164
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0308 0.126 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.0615 0.3643
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0513 0.1006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0144 0.0552 0.1081
Loa Loa (eye worm) hypothetical protein 0.0181 0.0711 0.4218
Plasmodium vivax glutathione reductase, putative 0.0049 0.014 0.2537
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0213 0.0418
Plasmodium vivax calpain, putative 0.0019 0.0007 0.013
Echinococcus granulosus beta LACTamase domain containing family member 0.0144 0.0552 0.1081
Leishmania major DNA polymerase eta, putative 0.0023 0.0027 0.0213
Plasmodium vivax sulfate transporter, putative 0.0084 0.0291 0.5268
Mycobacterium tuberculosis Conserved protein 0.0144 0.0552 0.0584
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0498 0.0976
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.0776 0.4601
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0521 0.2183 0.4278
Echinococcus multilocularis Smad4 0.0025 0.0033 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0055 0.044
Loa Loa (eye worm) hypothetical protein 0.0063 0.0199 0.1176
Schistosoma mansoni smad1 5 8 and 0.0025 0.0033 0.0066
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0114
Brugia malayi calpain 7 0.0019 0.0007 0.0043
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.012 0.07
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.014 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0062 0.0062
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0084 0.0291 0.4088
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0028 0.0159
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0287 0.1699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0036 0.0036
Schistosoma mansoni smad1 5 8 and 0.0025 0.0033 0.0066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0033 0.0066
Schistosoma mansoni ap endonuclease 0.0079 0.0267 0.0523
Echinococcus granulosus dna polymerase kappa 0.003 0.0055 0.0109
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0084 0.0164
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0032 0.0063
Schistosoma mansoni hypothetical protein 0.0024 0.0032 0.0063
Echinococcus granulosus geminin 0.1194 0.5104 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.005 0.0144 0.0282
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0088 0.0698
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0033 0.0066
Echinococcus granulosus calpain A 0.0066 0.0213 0.0418
Schistosoma mansoni jumonji/arid domain-containing protein 0.0024 0.0028 0.0056
Leishmania major hypothetical protein, conserved 0.0144 0.0552 0.4381
Schistosoma mansoni hypothetical protein 0.1194 0.5104 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0308 0.126 0.2469
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0027 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0079 0.0267 0.2118
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0081 0.0159
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0079 0.0267 1
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0163 0.129
Schistosoma mansoni polycystin 1-related 0.0024 0.0029 0.0057
Loa Loa (eye worm) inositol-1 0.0036 0.0081 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0088 0.0088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0079 0.0267 0.0282
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0181 0.0711 0.4224
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0027 0.0417
Brugia malayi Angiotensin-converting enzyme family protein 0.0287 0.1173 0.6964
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0024 0.0028 0.0056
Entamoeba histolytica hypothetical protein 0.0037 0.0087 0.1687
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0077 0.1086
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0002 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0498 0.0976
Onchocerca volvulus 0.0036 0.0084 0.025
Plasmodium falciparum thioredoxin reductase 0.0049 0.014 0.1969
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0007 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0144 0.0552 0.1081
Echinococcus granulosus carbonic anhydrase II 0.0308 0.126 0.2469
Schistosoma mansoni hypothetical protein 0.0109 0.0397 0.0777
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.0615 0.3643
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0129 0.0254
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0029 0.005 0.0097
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0081 0.0644
Mycobacterium leprae conserved hypothetical protein 0.0144 0.0552 0.1942
Loa Loa (eye worm) hypothetical protein 0.0058 0.0178 0.1046
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0059 0.0182 0.0357
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0199 0.1176
Plasmodium vivax SET domain protein, putative 0.0036 0.0084 0.1518
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0149
Loa Loa (eye worm) calpain 5 0.0019 0.0007 0.0032
Schistosoma mansoni lipoxygenase 0.0092 0.0324 0.0636
Schistosoma mansoni hypothetical protein 0.005 0.0144 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0776 0.152
Onchocerca volvulus 0.0102 0.0369 0.1552
Entamoeba histolytica hypothetical protein 0.0037 0.0087 0.1687
Loa Loa (eye worm) hypothetical protein 0.0089 0.031 0.1834
Brugia malayi exodeoxyribonuclease III family protein 0.0079 0.0267 0.1585
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0092 0.0324 0.0636
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.0117 0.0434 0.2571
Loa Loa (eye worm) hypothetical protein 0.0155 0.0597 0.3537
Plasmodium vivax hypothetical protein, conserved 0.0144 0.0552 1
Schistosoma mansoni smad 0.0025 0.0033 0.0066
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0059 0.0182 0.0357
Echinococcus granulosus sodium bile acid cotransporter 0.0102 0.0369 0.0722
Loa Loa (eye worm) hypothetical protein 0.0109 0.0397 0.2348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.0144 0.0552 0.0584
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0033 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0047 0.0047
Schistosoma mansoni jumonji domain containing protein 0.0024 0.0028 0.0056
Trypanosoma brucei antigen, putative 0.0019 0.0007 0.0057
Echinococcus multilocularis tar DNA binding protein 0.0196 0.0776 0.152
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0081 0.0644
Leishmania major hypothetical protein, conserved 0.0055 0.0163 0.129
Schistosoma mansoni inositol monophosphatase 0.0036 0.0081 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0055 0.044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0513 0.1006
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0081 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0046 0.0046
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0029 0.005 0.0097
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0079 0.0267 0.2118
Brugia malayi peptidase family M13 containing protein 0.0029 0.005 0.0294
Loa Loa (eye worm) hypothetical protein 0.0044 0.0118 0.0691
Schistosoma mansoni hypothetical protein 0.0181 0.0711 0.1394
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0079 0.0267 0.2118
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0114
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0027 0.016
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0002 0.0003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.0903 0.5356
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0007 0.0014
Loa Loa (eye worm) beta-lactamase 0.0144 0.0552 0.3271
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0024 0.0028 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0144 0.0552 0.0552
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.3451 0.6761
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0513 0.3042
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0084 0.0291 0.2308
Brugia malayi MH1 domain containing protein 0.0025 0.0033 0.0199
Schistosoma mansoni intermediate filament proteins 0.0083 0.0287 0.0563
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0081 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0036 0.0036
Echinococcus granulosus calpain 0.0019 0.0007 0.0014
Brugia malayi intermediate filament protein 0.0083 0.0287 0.1707
Mycobacterium tuberculosis Probable hydrolase 0.0144 0.0552 0.0584
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0055 0.0055
Schistosoma mansoni cellular tumor antigen P53 0.0155 0.0597 0.1169
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0084 0.0164
Schistosoma mansoni hypothetical protein 0.005 0.0144 0.0282
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0213 0.0418
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0213 0.0418
Brugia malayi hypothetical protein 0.0035 0.0079 0.0467
Mycobacterium ulcerans hypothetical protein 0.0144 0.0552 0.0552
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0007 0.0057
Schistosoma mansoni carbonic anhydrase-related 0.0181 0.0711 0.1394
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0027 0.0213
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.0615 0.365
Entamoeba histolytica hypothetical protein 0.0037 0.0087 0.1687
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0129 0.2592
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0017 0 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0122 0.0456 0.0893
Loa Loa (eye worm) hypothetical protein 0.0181 0.0711 0.4218
Schistosoma mansoni calpain (C02 family) 0.0019 0.0007 0.0014
Echinococcus multilocularis lysine specific demethylase 5A 0.0024 0.0028 0.0056
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0267 0.3752
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0114
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0058 0.0179 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0058 0.0058
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0007 0.0057
Plasmodium falciparum glutathione reductase 0.0049 0.014 0.1969
Onchocerca volvulus 0.0083 0.0287 0.1181
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0007 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.1006
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Loa Loa (eye worm) hypothetical protein 0.0089 0.031 0.1834
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0079 0.0267 0.5506
Echinococcus multilocularis sodium bile acid cotransporter 0.0102 0.0369 0.0722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0077 0.0077
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0081 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0163 0.129
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0002 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0513 0.1006
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0033 0.0189
Loa Loa (eye worm) hypothetical protein 0.0083 0.0287 0.1699
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0181 0.0711 0.4218
Onchocerca volvulus 0.0083 0.0287 0.1181
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.0711 0.4224
Entamoeba histolytica hypothetical protein 0.0037 0.0087 0.1687
Schistosoma mansoni lipoxygenase 0.0049 0.0139 0.0271
Schistosoma mansoni hypothetical protein 0.005 0.0144 0.0282
Schistosoma mansoni sodium-bile acid cotransporter related 0.0102 0.0369 0.0722
Leishmania major carbonic anhydrase family protein, putative 0.0128 0.0479 0.38
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0144 0.0853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0036 0.0036
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0007 0.0014
Toxoplasma gondii thioredoxin reductase 0.0049 0.014 0.1969
Trypanosoma cruzi hypothetical protein, conserved 0.0144 0.0552 0.4381
Echinococcus granulosus lamin 0.0083 0.0287 0.0563
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0129 0.1027
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0017 0 0.0002
Onchocerca volvulus 0.0155 0.0597 0.2594
Brugia malayi Pre-SET motif family protein 0.0254 0.1028 0.6104
Mycobacterium ulcerans integral membrane transporter 0.0084 0.0291 0.0291
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0007 0.0057
Trypanosoma cruzi kinesin, putative 0.0019 0.0007 0.0057
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0469 0.0497
Echinococcus multilocularis GPCR, family 2 0.005 0.0144 0.0282
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0027 0.0053
Brugia malayi hypothetical protein 0.0024 0.0029 0.0172
Giardia lamblia GTOR 0.0047 0.0129 0.485
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0163 0.2285
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0287 0.1707
Mycobacterium ulcerans alpha-L-fucosidase 0.0521 0.2183 0.2183
Brugia malayi Smad1 0.0025 0.0033 0.0199
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0002 0.0024
Echinococcus multilocularis RUN 0.0024 0.0029 0.0057
Trypanosoma cruzi kinesin, putative 0.0019 0.0007 0.0057
Brugia malayi Doublecortin family protein 0.0024 0.0029 0.0172
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0129 0.1027
Brugia malayi Alpha-L-fucosidase family protein 0.0405 0.1684 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0034 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0079 0.0267 0.0523
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0178 0.0697 0.0697
Brugia malayi MH2 domain containing protein 0.0025 0.0033 0.0199
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0308 0.126 0.7482
Echinococcus multilocularis calpain 0.0019 0.0007 0.0014
Echinococcus granulosus calpain A 0.0019 0.0007 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0498 0.0976
Mycobacterium tuberculosis Probable lipase LipE 0.0144 0.0552 0.0584
Mycobacterium tuberculosis Conserved protein 0.0144 0.0552 0.0584
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0114
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0007 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Brugia malayi calpain family protein 1 0.0063 0.0199 0.1185
Loa Loa (eye worm) hypothetical protein 0.0044 0.0118 0.0691
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0055 0.044
Echinococcus multilocularis calpain A 0.0066 0.0213 0.0418
Echinococcus multilocularis musashi 0.0083 0.0287 0.0563
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0033 0.0189
Trichomonas vaginalis esterase, putative 0.0144 0.0552 0.0552
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0922 0.3926 0.4156
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0547
Schistosoma mansoni alpha-l-fucosidase 0.0405 0.1684 0.3299
Echinococcus multilocularis lamin 0.0083 0.0287 0.0563
Loa Loa (eye worm) acetyltransferase 0.0058 0.0179 0.1053
Brugia malayi Pre-SET motif family protein 0.0036 0.0084 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0055 0.044
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.2854 0.5593
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0007 0.0057
Loa Loa (eye worm) hypothetical protein 0.0144 0.0552 0.3271
Loa Loa (eye worm) MH2 domain-containing protein 0.0364 0.1507 0.8946
Loa Loa (eye worm) hypothetical protein 0.0089 0.031 0.1834
Loa Loa (eye worm) hypothetical protein 0.0087 0.0301 0.1782
Echinococcus multilocularis tumor protein p63 0.1057 0.4509 0.8835
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0002 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0079 0.0267 0.2118
Loa Loa (eye worm) alpha-L-fucosidase 0.0405 0.1684 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0369 0.2181
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0029 0.0057
Schistosoma mansoni rab6-interacting 0.0024 0.0029 0.0057
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0029 0.005 0.0097
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0029 0.005 0.0097
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0118 0.0231
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0114
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0007 0.0057
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0029 0.0526
Echinococcus granulosus microtubule associated protein 2 0.0675 0.2854 0.5593
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0022 0.0175
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0055 0.044

Activities

Activity type Activity value Assay description Source Reference
Log ESA (functional) = -0.688 Everted sac permeability (ESA) of rat small intestine, after addition of thrombin inhibitor ChEMBL. 10987422

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.