Detailed information for compound 878295

Basic information

Technical information
  • TDR Targets ID: 878295
  • Name: N-(2-bromo-4-methylphenyl)-2-cyano-3-(4-metho xyphenyl)prop-2-enamide
  • MW: 371.228 | Formula: C18H15BrN2O2
  • H donors: 1 H acceptors: 2 LogP: 4.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1ccc(cc1)OC)C(=O)Nc1ccc(cc1Br)C
  • InChi: 1S/C18H15BrN2O2/c1-12-3-8-17(16(19)9-12)21-18(22)14(11-20)10-13-4-6-15(23-2)7-5-13/h3-10H,1-2H3,(H,21,22)/b14-10+
  • InChiKey: HMFZOZDZOUXPPA-GXDHUFHOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-(2-bromo-4-methylphenyl)-2-cyano-3-(4-methoxyphenyl)prop-2-enamide
  • N-(2-bromo-4-methyl-phenyl)-2-cyano-3-(4-methoxyphenyl)prop-2-enamide
  • (E)-N-(2-bromo-4-methyl-phenyl)-2-cyano-3-(4-methoxyphenyl)prop-2-enamide
  • (E)-N-(2-bromo-4-methyl-phenyl)-2-cyano-3-(4-methoxyphenyl)acrylamide
  • N-(2-bromo-4-methyl-phenyl)-2-cyano-3-(4-methoxyphenyl)acrylamide
  • ST5185985
  • ZINC00942027

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0275 0.0275
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0393 0.0934
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0089
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0142 0.1045 0.2484
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.0096 0.0229
Mycobacterium ulcerans hypothetical protein 0.0074 0.0475 0.2052
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0049 0.0262 0.0623
Loa Loa (eye worm) hypothetical protein 0.0074 0.0475 0.0475
Giardia lamblia Hypothetical protein 0.0142 0.1045 0.243
Brugia malayi Death domain containing protein 0.0029 0.0096 0.0096
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0291 0.0692
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1262 0.3
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.003 0.0072
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0263 0.206 0.4862
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0064 0.0393 0.0934
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0049 0.0262 0.0623
Mycobacterium tuberculosis Conserved protein 0.0074 0.0475 0.1173
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1262 0.3
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0475 0.1128
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.041 0.0974
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0475 0.1128
Toxoplasma gondii aspartyl protease ASP3 0.0028 0.0089 0.1879
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0475 0.1128
Plasmodium vivax glutathione reductase, putative 0.0048 0.0254 0.0603
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0049 0.0262 0.0623
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.0262 0.0623
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1338 0.318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0262 0.0623
Plasmodium falciparum glutathione reductase 0.0048 0.0254 0.0603
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0846 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0142 0.1045 0.2484
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0049 0.0262 0.0555
Plasmodium falciparum plasmepsin VI 0.0064 0.0393 0.0934
Schistosoma mansoni netrin receptor unc5 0.0029 0.0096 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0475 0.1128
Trypanosoma cruzi N-myristoyl transferase, putative 0.0518 0.4206 1
Plasmodium falciparum plasmepsin V 0.0028 0.0089 0.0212
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0262 0.0623
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0475 0.1173
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.003 0.0072
Plasmodium vivax aspartyl proteinase, putative 0.0064 0.0393 0.0934
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.041 0.0974
Trichomonas vaginalis esterase, putative 0.0074 0.0475 0.1128
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0263 0.206 0.4899
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0475 0.1173
Plasmodium vivax aspartyl protease, putative 0.0028 0.0089 0.0212
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0475 0.1173
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2 0.4754
Plasmodium falciparum plasmepsin IV 0.0064 0.0393 0.0934
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0475 0.1128
Schistosoma mansoni N-myristoyltransferase 0.0518 0.4206 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0275 0.0654
Toxoplasma gondii exonuclease III APE 0.0021 0.003 0.0635
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0262 0.0623
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0475 0.1128
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.003 0.0072
Trypanosoma brucei N-myristoyltransferase 0.0518 0.4206 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0475 0.1128
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.003 0.003
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0263 0.206 0.4899
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0475 0.1173
Brugia malayi NAD-dependent deacetylase SIRT1 0.0263 0.206 0.206
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0096 0.0096
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0142 0.1045 0.2484
Leishmania major N-myristoyl transferase, putative 0.0518 0.4206 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0275 0.0654
Mycobacterium ulcerans Sir2-like regulatory protein 0.0049 0.0262 0.107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.003 0.0072
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.0262 0.0262
Mycobacterium tuberculosis Conserved protein 0.0074 0.0475 0.1173
Schistosoma mansoni ap endonuclease 0.0021 0.003 0.0072
Brugia malayi aspartic protease BmAsp-1, identical 0.0028 0.0089 0.0089
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1262 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0275 0.0654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0275 0.0654
Plasmodium vivax NAD-dependent deacetylase, putative 0.0049 0.0262 0.0623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0096 0.0096
Brugia malayi beta-lactamase family protein 0.0074 0.0475 0.0475
Schistosoma mansoni chromatin regulatory protein sir2 0.0142 0.1045 0.2484
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0262 0.0623
Echinococcus granulosus Ankyrin 0.0029 0.0096 0.0229
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0765 0.1941
Toxoplasma gondii aspartyl protease ASP1 0.0064 0.0393 0.8276
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0765 0.1941
Schistosoma mansoni cathepsin D (A01 family) 0.0156 0.1167 0.2776
Leishmania major cathepsin L-like protease 0.0066 0.041 0.0974
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0475 0.1173
Brugia malayi hypothetical protein 0.0028 0.0089 0.0089
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.003 0.5
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0049 0.0262 0.0623
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0064 0.0393 0.0934
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0089
Plasmodium vivax aspartyl protease, putative 0.0028 0.0089 0.0212
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0254 0.0603
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0089 0.0212
Onchocerca volvulus 0.0074 0.0475 0.3761
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0475 0.1128
Plasmodium vivax plasmepsin V, putative 0.0028 0.0089 0.0212
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.0262 0.0262
Brugia malayi glutaminase DH11.1 0.0279 0.2196 0.2196
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0262 0.0623
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1262 0.3
Loa Loa (eye worm) hypothetical protein 0.0064 0.0393 0.0393
Plasmodium falciparum plasmepsin I 0.0064 0.0393 0.0934
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0049 0.0262 0.0612
Loa Loa (eye worm) transcriptional regulator 0.0049 0.0262 0.0262
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0049 0.0262 0.0623
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1338 0.318
Loa Loa (eye worm) hypothetical protein 0.0074 0.0475 0.0475
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0089 0.0212
Loa Loa (eye worm) glutaminase 2 0.0279 0.2196 0.2196
Schistosoma mansoni memapsin-2 (A01 family) 0.0429 0.3459 0.8224
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0044 0.0224 0.0532
Trypanosoma brucei N-myristoyl transferase, putative 0.0518 0.4206 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0475 0.0475
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0049 0.0262 0.0623
Loa Loa (eye worm) hypothetical protein 0.0214 0.1653 0.1653
Mycobacterium ulcerans glutaminase 0.0279 0.2196 1
Echinococcus multilocularis chromatin regulatory protein sir2 0.0142 0.1045 0.2484
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0089 0.0212
Brugia malayi Thioredoxin reductase 0.0048 0.0254 0.0254
Loa Loa (eye worm) glutaminase 0.0279 0.2196 0.2196
Loa Loa (eye worm) glutathione reductase 0.0048 0.0254 0.0254
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0028 0.0089 0.1879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1209 1 1
Echinococcus granulosus death domain containing protein 0.0029 0.0096 0.0229
Brugia malayi aspartic protease BmAsp-2, identical 0.0028 0.0089 0.0089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0275 0.0654
Brugia malayi Pepsin A precursor 0.0028 0.0089 0.0089
Leishmania major cathepsin L-like protease 0.0066 0.041 0.0974
Loa Loa (eye worm) hypothetical protein 0.0074 0.0475 0.0475
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0475 0.1128
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0262 0.0623
Loa Loa (eye worm) transcriptional regulator 0.0142 0.1045 0.1045
Trypanosoma brucei SIR2-like protein 4, putative 0.0049 0.0262 0.0555
Plasmodium falciparum thioredoxin reductase 0.0048 0.0254 0.0603
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0475 0.1128
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0475 0.2052
Plasmodium vivax plasmepsin IV, putative 0.0064 0.0393 0.0934
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0142 0.1045 0.2484
Schistosoma mansoni chromatin regulatory protein sir2 0.0142 0.1045 0.2484
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0254 0.0603
Schistosoma mansoni tumor necrosis factor receptor related 0.0044 0.0224 0.0532
Loa Loa (eye worm) hypothetical protein 0.0074 0.0475 0.0475
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0089 0.0212
Brugia malayi MH2 domain containing protein 0.0118 0.0846 0.0846
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0475 0.1173
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0254 0.059
Mycobacterium tuberculosis Conserved protein 0.0074 0.0475 0.1173
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0142 0.1045 0.2484
Schistosoma mansoni ap endonuclease 0.0021 0.003 0.0072
Loa Loa (eye worm) transcriptional regulator 0.0049 0.0262 0.0262
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.003 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2 0.4754
Schistosoma mansoni chromatin regulatory protein sir2 0.0263 0.206 0.4899
Mycobacterium tuberculosis Probable reductase 0.0109 0.0765 0.1941
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0262 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Echinococcus multilocularis netrin receptor unc 5 0.0029 0.0096 0.0229
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0475 0.0475
Leishmania major silent information regulator 2, putative 0.0142 0.1045 0.2484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Leishmania major sir2-family protein-like protein 0.0049 0.0262 0.0623
Loa Loa (eye worm) hypothetical protein 0.0074 0.0475 0.0475
Trypanosoma cruzi N-myristoyl transferase, putative 0.0518 0.4206 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0089 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0275 0.0654
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1262 0.3
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0254 0.0603
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0254 0.0254
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0262 0.0623
Brugia malayi N-myristoyltransferase 2 0.0518 0.4206 0.4206
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.3818 1
Mycobacterium ulcerans NAD-dependent deacetylase 0.0049 0.0262 0.107
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0044 0.0224 0.0532
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0142 0.1045 0.243
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1262 0.3
Loa Loa (eye worm) beta-lactamase 0.0074 0.0475 0.0475
Plasmodium falciparum plasmepsin IX 0.0028 0.0089 0.0212
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0475 0.1064
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0263 0.206 0.4899
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0096
Toxoplasma gondii aspartyl protease 0.0028 0.0089 0.1879
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2 0.4754
Plasmodium falciparum plasmepsin VIII, putative 0.0028 0.0089 0.0212
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0099 0.0682 0.1621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.003 0.0072
Mycobacterium ulcerans lipase LipD 0.0074 0.0475 0.2052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0867 0.221
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0475 0.0475
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.003 0.0072
Mycobacterium ulcerans beta-lactamase 0.0074 0.0475 0.2052
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.0262 0.0623
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0867 0.221
Loa Loa (eye worm) subtilase 0.0263 0.2065 0.2065
Giardia lamblia Transcriptional regulator, Sir2 family 0.0049 0.0262 0.0555
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0765 0.7409
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1262 0.3
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.041 0.0974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0846 0.0846
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0475 0.1128
Toxoplasma gondii thioredoxin reductase 0.0048 0.0254 0.5344
Brugia malayi beta-lactamase family protein 0.0074 0.0475 0.0475
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0049 0.0262 0.0623
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0765 0.1941
Echinococcus multilocularis Ankyrin 0.0029 0.0096 0.0229
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0099 0.0682 0.1621
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0867 0.221
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.003 0.003
Onchocerca volvulus 0.0028 0.0089 0.0707
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0044 0.0224 0.0532
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0275 0.0275
Giardia lamblia Sirtuin type 2 0.0049 0.0262 0.0555
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.041 0.0974
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.003 0.0072
Echinococcus granulosus chromatin regulatory protein sir2 0.0142 0.1045 0.2484
Trypanosoma brucei trypanothione reductase 0.0048 0.0254 0.0535
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0765 0.1941
Loa Loa (eye worm) hypothetical protein 0.0263 0.206 0.206
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2 0.4754
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0518 0.4206 1
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2 0.4754
Loa Loa (eye worm) N-myristoyltransferase 2 0.0518 0.4206 0.4206
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0263 0.206 0.4899
Schistosoma mansoni glutaminase 0.0279 0.2196 0.5222
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0263 0.2065 0.4909
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0064 0.0393 0.0393
Plasmodium vivax aspartyl protease, putative 0.0028 0.0089 0.0212
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0049 0.0262 0.0623
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0089 0.0212
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0142 0.1045 0.2484
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0518 0.4206 1
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0518 0.4206 1
Brugia malayi Uncoordinated protein 44 0.0029 0.0096 0.0096
Giardia lamblia CDC72 0.0518 0.4206 1
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0064 0.0393 0.0934
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0518 0.4206 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0096
Echinococcus granulosus netrin receptor unc 5 0.0029 0.0096 0.0229
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0475 0.1128
Trichomonas vaginalis N-myristoyl transferase, putative 0.0518 0.4206 1
Brugia malayi hypothetical protein 0.0028 0.0089 0.0089
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.003 0.5
Leishmania major hypothetical protein, conserved 0.0074 0.0475 0.1128
Loa Loa (eye worm) sirtuin 4 0.0049 0.0262 0.0262
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.0096 0.0229
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0049 0.0262 0.0623
Brugia malayi glutathione reductase 0.0048 0.0254 0.0254
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.0096 0.0229
Loa Loa (eye worm) aspartyl protease 6 0.0028 0.0089 0.0089
Toxoplasma gondii histone deacetylase SIR2 0.0049 0.0262 0.5519
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.003 0.0072
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0362 0.086
Onchocerca volvulus 0.0074 0.0475 0.3761
Brugia malayi beta-lactamase 0.0074 0.0475 0.0475
Plasmodium vivax aspartyl proteinase, putative 0.0028 0.0089 0.0212
Plasmodium falciparum plasmepsin X 0.0028 0.0089 0.0212
Onchocerca volvulus 0.0028 0.0089 0.0707
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0867 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0096 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0765 0.1941
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0064 0.0393 0.8276
Onchocerca volvulus Netrin receptor homolog 0.0029 0.0096 0.0764
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0263 0.206 0.4899
Plasmodium falciparum plasmepsin III 0.0028 0.0089 0.0212
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0089 0.0212
Plasmodium falciparum plasmepsin II 0.0064 0.0393 0.0934
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.2 0.2
Trichomonas vaginalis N-myristoyl transferase, putative 0.0341 0.2713 0.6451
Toxoplasma gondii histone deacetylase SIR2-like 0.0049 0.0262 0.5519
Leishmania major cathepsin L-like protease 0.0066 0.041 0.0974
Brugia malayi transcriptional regulator, Sir2 family protein 0.0142 0.1045 0.1045
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.2 0.2
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0262 0.0623
Trichomonas vaginalis glutaminase, putative 0.0279 0.2196 0.5222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.041 0.0909
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2 0.4754
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0142 0.1045 0.2484
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.003 0.0072
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0089 0.0212
Schistosoma mansoni cathepsin D (A01 family) 0.0156 0.1167 0.2776
Onchocerca volvulus 0.0074 0.0475 0.3761
Schistosoma mansoni hypothetical protein 0.0029 0.0096 0.0229
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0044 0.0224 0.0532
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0518 0.4206 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0028 0.0089 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1262 0.3
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0142 0.1045 0.2484
Schistosoma mansoni chromatin regulatory protein sir2 0.0142 0.1045 0.2484
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0475 0.1173
Brugia malayi Protein kinase domain containing protein 0.0029 0.0096 0.0096
Leishmania major trypanothione reductase 0.0048 0.0254 0.0603
Plasmodium falciparum plasmepsin VII 0.0028 0.0089 0.0212
Brugia malayi Subtilase family protein 0.0263 0.2065 0.2065
Brugia malayi Eukaryotic aspartyl protease family protein 0.0028 0.0089 0.0089
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0475 0.2052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0275 0.0654
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0263 0.206 0.4899
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0254 0.0603
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0262 0.0623
Toxoplasma gondii ABC1 family protein 0.0074 0.0475 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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