Detailed information for compound 881786

Basic information

Technical information
  • TDR Targets ID: 881786
  • Name: 1-(5-chloro-1,3-dimethylpyrazol-4-yl)sulfonyl -4-(4-methoxyphenyl)piperazine
  • MW: 384.881 | Formula: C16H21ClN4O3S
  • H donors: 0 H acceptors: 3 LogP: 2.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1c(C)nn(c1Cl)C
  • InChi: 1S/C16H21ClN4O3S/c1-12-15(16(17)19(2)18-12)25(22,23)21-10-8-20(9-11-21)13-4-6-14(24-3)7-5-13/h4-7H,8-11H2,1-3H3
  • InChiKey: IJVVQGVVEBIVLI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(5-chloro-1,3-dimethyl-pyrazol-4-yl)sulfonyl-4-(4-methoxyphenyl)piperazine
  • 1-[(5-chloro-1,3-dimethyl-4-pyrazolyl)sulfonyl]-4-(4-methoxyphenyl)piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.025 0.0778
Echinococcus granulosus serotonin receptor 0.0049 0.0273 0.0696
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0071 0.0335
Loa Loa (eye worm) hypothetical protein 0.0107 0.0679 0.065
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.0723
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0273 0.0243
Entamoeba histolytica hypothetical protein 0.01 0.0628 0.2618
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0273 0.0696
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.025 0.1042
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0219 0.0621
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0273 0.0696
Echinococcus multilocularis heat shock protein 90 0.0039 0.0203 0.0495
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0298 0.1213
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0141 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Echinococcus multilocularis serotonin receptor 0.0049 0.0273 0.0696
Echinococcus granulosus heat shock protein 90 0.0039 0.0203 0.0495
Trichomonas vaginalis heat shock protein, putative 0.0046 0.025 0.1387
Schistosoma mansoni adenoreceptor 0.0049 0.0273 0.0774
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.016 0.0453
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.01 0.0628 0.2618
Schistosoma mansoni histamine h1 receptor 0.0049 0.0273 0.0774
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.025 0.1008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0272 0.0692
Schistosoma mansoni amine GPCR 0.0049 0.0273 0.0774
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0184 0.1016
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0071 0.0122
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0273 0.0774
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0046 0.0251 0.1013
Trypanosoma cruzi Emopamil binding protein, putative 0.0137 0.0893 0.3767
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0272 0.0242
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0273 0.0696
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Trypanosoma brucei lanosterol synthase 0.0198 0.1327 0.5628
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0273 0.0243
Onchocerca volvulus 0.0049 0.0273 0.0138
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0273 0.0696
Brugia malayi neuropeptide F receptor 0.0049 0.0273 0.0737
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.016 0.1064
Schistosoma mansoni hypothetical protein 0.0049 0.0272 0.077
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0069 0.0112
Brugia malayi GnHR receptor homolog 0.0049 0.0273 0.0737
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0372
Echinococcus granulosus Peptidase C54 0.0119 0.0763 0.2098
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.099 0.2745
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0273 0.0138
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0043 0.023 1
Onchocerca volvulus 0.0049 0.0273 0.0138
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0171 0.1164
Echinococcus granulosus g protein coupled receptor 0.0049 0.0273 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Echinococcus multilocularis dnaJ subfamily B 0.0452 0.3118 0.8828
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0272 0.0692
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0095 0.0518
Echinococcus granulosus cpg binding protein 0.0096 0.0606 0.1648
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0273 0.0774
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0763 0.4263
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0219 0.0542
Plasmodium vivax SET domain protein, putative 0.0035 0.0171 0.1226
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0273 0.0737
Brugia malayi Serotonin receptor 0.0049 0.0273 0.0737
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0137 0.0308
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0237 0.1744
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.016 0.1124
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0826 0.0798
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0184 0.1016
Trypanosoma cruzi phospholipase A1, putative 0.0342 0.2346 1
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0763 0.321
Onchocerca volvulus 0.0049 0.0273 0.0138
Echinococcus multilocularis somatostatin receptor 0.0049 0.0273 0.0696
Trypanosoma brucei Sterol methyltransferase, putative 0.0219 0.1472 0.6252
Schistosoma mansoni ran 0.0021 0.0069 0.0195
Entamoeba histolytica peptidase, C54 family 0.0046 0.0251 0.1048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0084 0.0455
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0093 0.0181
Schistosoma mansoni amine GPCR 0.0049 0.0273 0.0774
Schistosoma mansoni hypothetical protein 0.003 0.0137 0.0389
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0273 0.0696
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0069 0.0117
Brugia malayi TAR-binding protein 0.0127 0.0826 0.2415
Trypanosoma brucei heat shock protein, putative 0.0046 0.025 0.1008
Schistosoma mansoni hypothetical protein 0.051 0.3528 1
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.025 0.1008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Entamoeba histolytica hypothetical protein 0.004 0.0205 0.0854
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0219 0.1472 0.6252
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Echinococcus multilocularis cpg binding protein 0.0096 0.0606 0.1648
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0203 0.0805
Trichomonas vaginalis helicase, putative 0.0021 0.007 0.038
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.016 0.062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Brugia malayi hypothetical protein 0.0034 0.0165 0.041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0211 0.0881
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0137 0.0308
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Leishmania major phospholipase A1, putative 0.0342 0.2346 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0171 0.0485
Loa Loa (eye worm) hypothetical protein 0.0052 0.029 0.026
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Onchocerca volvulus 0.0342 0.2346 0.224
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.1023 0.3014
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus granulosus vesicular acetylcholine transporter 0.0481 0.3323 0.9414
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.025 0.1008
Echinococcus granulosus cysteine protease atg4b 0.0119 0.0763 0.2098
Echinococcus multilocularis GPCR, family 2 0.0049 0.0272 0.0692
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0141 0.0317
Brugia malayi Isocitrate dehydrogenase 0.0033 0.016 0.0393
Echinococcus multilocularis endoplasmin 0.0043 0.023 0.0573
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0219 0.1472 0.6252
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0273 0.0737
Onchocerca volvulus 0.0049 0.0273 0.0138
Schistosoma mansoni hypothetical protein 0.0049 0.0273 0.0774
Echinococcus multilocularis survival motor neuron protein 1 0.0254 0.1719 0.483
Trypanosoma brucei heat shock protein, putative 0.0046 0.025 0.1008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0763 0.321
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0273 0.0774
Brugia malayi Bromodomain containing protein 0.0034 0.0163 0.0404
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0084 0.0455
Plasmodium vivax heat shock protein, putative 0.0175 0.116 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis neuropeptide s receptor 0.0049 0.0273 0.0696
Toxoplasma gondii Hsp90 domain-containing protein 0.0175 0.116 0.9814
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.007 0.038
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0273 0.0243
Toxoplasma gondii exonuclease III APE 0.0021 0.0071 0.0286
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0092 0.0178
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0273 0.0696
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.016 0.0372
Echinococcus multilocularis peregrin 0.0034 0.0163 0.0383
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0071 0.061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0272 0.0692
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0148 0.034
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0273 0.0243
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.007 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0046 0.0251 0.1013
Schistosoma mansoni ap endonuclease 0.0021 0.0071 0.02
Schistosoma mansoni neuropeptide receptor 0.0049 0.0273 0.0774
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0273 0.0696
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0093 0.0181
Entamoeba histolytica hypothetical protein 0.004 0.0205 0.0854
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0046 0.0251 0.1013
Schistosoma mansoni importin beta-1 0.0028 0.0121 0.0343
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.007 0.038
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0273 0.0774
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0273 0.0774
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0156 0.1091
Schistosoma mansoni endoplasmin 0.0046 0.025 0.0709
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0203 0.1123
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0184 0.1274
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0623 0.1696
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0273 0.0696
Leishmania major heat shock protein, putative 0.0031 0.0141 0.0538
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0137 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0826 0.234
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0273 0.0243
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0272 0.0242
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.007 0.038
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Loa Loa (eye worm) hypothetical protein 0.0375 0.2574 0.2552
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0182 0.0436
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0623 0.1696
Brugia malayi Serotonin receptor 0.0049 0.0273 0.0737
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0184 0.7092
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0826 0.2415
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0071 0.0238
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0113 0.0622
Brugia malayi G-protein coupled receptor 0.0049 0.0273 0.0737
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0141 0.0897
Brugia malayi isocitrate dehydrogenase 0.0033 0.016 0.0393
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0273 0.0138
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0205 0.0581
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0015 0.0063
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0273 0.0696
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0273 0.0696
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.025 0.1008
Loa Loa (eye worm) hypothetical protein 0.003 0.0137 0.0107
Echinococcus multilocularis snurportin 1 0.0297 0.2027 0.571
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0273 0.0774
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0071 0.0118
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0184 0.7092
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0184 0.1016
Trypanosoma cruzi lanosterol synthase, putative 0.0198 0.1327 0.5628
Schistosoma mansoni hypothetical protein 0.0024 0.0092 0.026
Plasmodium falciparum phd finger protein, putative 0.003 0.0137 0.1184
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0372
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.0203 0.0495
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.0893 0.3767
Echinococcus granulosus GPCR family 2 0.0049 0.0272 0.0692
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0046 0.0251 0.1865
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0365 0.0335
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0237 0.1316
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.035 0.2398 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Giardia lamblia PHD finger protein 15 0.003 0.0137 0.0294
Onchocerca volvulus 0.0052 0.029 0.0155
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.096 0.266
Brugia malayi heat shock protein 90 0.0046 0.025 0.0667
Echinococcus multilocularis cysteine protease atg4b 0.0119 0.0763 0.2098
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.025 0.1008
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0273 0.0696
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0114 0.0731 0.3073
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0161 0.0886
Onchocerca volvulus 0.0049 0.0273 0.0138
Brugia malayi larval opioid receptor 0.0049 0.0273 0.0737
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.016 0.013
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0015 0.0033 0.0284
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0273 0.0737
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0273 0.0696
Loa Loa (eye worm) RNA binding protein 0.0127 0.0826 0.0798
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0171 0.0405
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0273 0.0774
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0273 0.0696
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0205 0.0501
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0069 0.0039
Echinococcus granulosus tar DNA binding protein 0.0127 0.0826 0.2276
Loa Loa (eye worm) RecQ helicase 0.0024 0.0095 0.0065
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0273 0.0696
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0273 0.0774
Schistosoma mansoni biogenic amine receptor 0.0049 0.0273 0.0774
Schistosoma mansoni hypothetical protein 0.0049 0.0273 0.0774
Trypanosoma brucei phospholipase A1, putative 0.0342 0.2346 1
Leishmania major sterol 24-c-methyltransferase, putative 0.0219 0.1472 0.6252
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0128 0.0098
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0095 0.0186
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0141 0.0538
Echinococcus granulosus neuropeptide receptor A26 0.0049 0.0273 0.0696
Trypanosoma cruzi phospholipase A1, putative 0.0342 0.2346 1
Plasmodium vivax heat shock protein 86, putative 0.0046 0.025 0.1926
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0071 0.0118
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0273 0.0696
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.099 0.2806
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis geminin 0.051 0.3528 1
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Onchocerca volvulus 0.0049 0.0273 0.0138
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0219 0.1472 0.6252
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0273 0.0696
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0272 0.0732
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0273 0.0774
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0273 0.0696
Onchocerca volvulus 0.0049 0.0273 0.0138
Echinococcus granulosus hypothetical protein 0.0049 0.0273 0.0696
Leishmania major sterol 24-c-methyltransferase, putative 0.0219 0.1472 0.6252
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0137 0.0389
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.1563 0.1538
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0298 0.2569
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0273 0.0774
Trypanosoma brucei heat shock protein, putative 0.0046 0.025 0.1008
Schistosoma mansoni inositol monophosphatase 0.0037 0.0184 0.0521
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.016 0.1377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0298 0.2352
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Brugia malayi RNA, U transporter 1 0.0079 0.0484 0.1378
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Echinococcus granulosus neuropeptide receptor 0.0049 0.0273 0.0696
Echinococcus granulosus somatostatin receptor 0.0049 0.0273 0.0696
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Schistosoma mansoni neuropeptide receptor 0.0049 0.0273 0.0774
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0093 0.0181
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0195 0.1301 0.3689
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0273 0.0696
Brugia malayi CXXC zinc finger family protein 0.0091 0.0569 0.1636
Brugia malayi Pre-SET motif family protein 0.0035 0.0171 0.0427
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Toxoplasma gondii heat shock protein HSP90 0.0046 0.025 0.1854
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0237 0.1814
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0171 0.0405
Brugia malayi RNA binding protein 0.0127 0.0826 0.2415
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0171 0.0485
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Onchocerca volvulus 0.0049 0.0273 0.0138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0171 0.0405
Schistosoma mansoni hypothetical protein 0.0049 0.0272 0.077
Schistosoma mansoni hypothetical protein 0.0106 0.0675 0.1914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0273 0.0737
Giardia lamblia Grp94/Hsp90 0.0043 0.023 0.0692
Loa Loa (eye worm) acetyltransferase 0.0151 0.099 0.0962
Echinococcus granulosus survival motor neuron protein 1 0.0254 0.1719 0.483
Schistosoma mansoni opsin-like receptor 0.0049 0.0273 0.0774
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0826 0.234
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0071 0.0238
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0137 0.0868
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0273 0.0774
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0273 0.0696
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0071 0.0383
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0221 0.0547
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.023 0.2026
Loa Loa (eye worm) heat shock protein 90 0.0046 0.025 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0273 0.0696
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0121 0.0725
Schistosoma mansoni hypothetical protein 0.051 0.3528 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0121 0.078
Brugia malayi AKH receptor 0.0049 0.0273 0.0737
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0119 0.0763 0.321
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Onchocerca volvulus 0.0342 0.2346 0.224
Brugia malayi neuropeptide F receptor 0.0049 0.0273 0.0737
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0273 0.0696
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0069 0.023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.007 0.038
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0028 0.0121 0.0091
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0272 0.0732
Loa Loa (eye worm) hypothetical protein 0.0155 0.1023 0.0995
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.007 0.038
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0092 0.0178
Schistosoma mansoni amine GPCR 0.0049 0.0273 0.0774
Onchocerca volvulus 0.0049 0.0273 0.0138
Echinococcus granulosus fmrfamide receptor 0.0049 0.0273 0.0696
Brugia malayi Phospholipase A2 family protein 0.0375 0.2574 0.7726
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0298 0.2569
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0273 0.0696
Brugia malayi jmjC domain containing protein 0.0042 0.0219 0.0573
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0273 0.0696
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.029 0.0789
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0273 0.0737
Entamoeba histolytica peptidase, C54 family 0.0119 0.0763 0.3183
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0069 0.023
Toxoplasma gondii heat shock protein 90, putative 0.0046 0.025 0.1854
Schistosoma mansoni biogenic amine receptor 0.0049 0.0273 0.0774
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.0723
Entamoeba histolytica Ran family GTPase 0.0021 0.0069 0.0287
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Brugia malayi Cytochrome P450 family protein 0.0029 0.0128 0.0297
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0763 0.4263
Schistosoma mansoni cpg binding protein 0.0091 0.0569 0.1613
Plasmodium vivax endoplasmin, putative 0.0046 0.025 0.1926
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0273 0.0243
Schistosoma mansoni heat shock protein 0.0046 0.025 0.0709
Loa Loa (eye worm) hypothetical protein 0.0122 0.0784 0.0756
Brugia malayi Dopamine receptor 0.0049 0.0273 0.0737
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0071 0.0238
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0273 0.0696
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0237 0.0594
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Schistosoma mansoni hypothetical protein 0.0049 0.0272 0.077
Loa Loa (eye worm) hypothetical protein 0.0254 0.1719 0.1694
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0826 0.234
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.062
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0273 0.0774
Trypanosoma brucei heat shock protein, putative 0.0046 0.025 0.1008
Echinococcus granulosus orexin receptor type 2 0.0049 0.0273 0.0696
Onchocerca volvulus 0.0342 0.2346 0.224
Plasmodium falciparum endoplasmin, putative 0.0033 0.0161 0.1384
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0046 0.0251 0.1013
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0221 0.0547
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.1181 1
Entamoeba histolytica hypothetical protein 0.004 0.0205 0.0854
Schistosoma mansoni cpg binding protein 0.0096 0.0606 0.1718
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0273 0.0696
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.007 0.038
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0237 0.1316
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0273 0.0696
Brugia malayi Dopamine receptor protein 1 0.0049 0.0273 0.0737
Echinococcus granulosus peregrin 0.0034 0.0163 0.0383
Schistosoma mansoni vesicular acetylcholine transporter 0.0481 0.3323 0.9419
Onchocerca volvulus 0.0049 0.0273 0.0138
Trypanosoma brucei Emopamil binding protein, putative 0.0137 0.0893 0.3767
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Onchocerca volvulus 0.0049 0.0273 0.0138
Brugia malayi vesicular acetylcholine transporter unc-17 0.0481 0.3323 1
Brugia malayi hypothetical protein 0.0053 0.0298 0.0813
Trichomonas vaginalis ran, putative 0.0021 0.0069 0.0373
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0132 0.0293
Schistosoma mansoni survival motor neuron protein 0.0052 0.029 0.0822
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0095 0.0518
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0025 0.0071
Onchocerca volvulus 0.0049 0.0273 0.0138
Onchocerca volvulus 0.0264 0.1788 0.1673
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0049 0.0273 0.0243
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0069 0.027
Brugia malayi PHD-finger family protein 0.003 0.0137 0.0325
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0211 0.0611
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0069 0.023
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0071 0.0383
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0141 0.0954
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0298 0.1213
Trichomonas vaginalis set domain proteins, putative 0.0264 0.1788 1
Brugia malayi Dopamine receptor protein 2 0.0049 0.0273 0.0737
Echinococcus multilocularis neuropeptide receptor A26 0.0049 0.0273 0.0696
Plasmodium falciparum heat shock protein 90, putative 0.0175 0.116 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0273 0.0774
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.099 0.2914
Echinococcus granulosus importin subunit beta 1 0.0028 0.0121 0.0261
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0132 0.0293
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.062
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.0723
Echinococcus multilocularis heat shock protein 0.0046 0.025 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Trypanosoma brucei heat shock protein, putative 0.0046 0.025 0.1008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0084 0.0294
Onchocerca volvulus 0.0049 0.0273 0.0138
Echinococcus granulosus dnaJ subfamily B 0.0452 0.3118 0.8828
Trichomonas vaginalis heat shock protein, putative 0.0043 0.023 0.1275
Echinococcus multilocularis Peptidase C54 0.0119 0.0763 0.2098
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Echinococcus granulosus bloom syndrome protein 0.0024 0.0095 0.0186
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0039 0.0057
Schistosoma mansoni heat shock protein 0.0046 0.025 0.0709
Schistosoma mansoni autophagin-1 (C54 family) 0.0119 0.0763 0.2164
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0141 0.0538
Trypanosoma brucei heat shock protein, putative 0.0046 0.025 0.1008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0273 0.0696
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.023 0.0922
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0342 0.2346 0.2323
Brugia malayi Importin beta-1 subunit 0.0028 0.0121 0.0275
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0059 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Schistosoma mansoni amine GPCR 0.0049 0.0273 0.0774
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0273 0.0696
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0273 0.0696
Entamoeba histolytica hypothetical protein 0.004 0.0205 0.0854
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0219 0.0189
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0481 0.3323 0.323
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0273 0.0774
Brugia malayi hypothetical protein 0.0254 0.1719 0.5129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0171 0.0485
Leishmania major lanosterol synthase, putative 0.0198 0.1327 0.5628
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Brugia malayi Inositol-1 0.0037 0.0184 0.0465
Echinococcus granulosus endoplasmin 0.0043 0.023 0.0573
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0205 0.0501
Echinococcus multilocularis vesicular acetylcholine transporter 0.0481 0.3323 0.9414
Echinococcus granulosus g protein coupled receptor 0.0049 0.0273 0.0696
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0273 0.0774
Echinococcus granulosus sex peptide receptor 0.0049 0.0273 0.0696
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0481 0.3323 0.3303
Echinococcus granulosus heat shock protein 0.0046 0.025 0.063
Echinococcus granulosus snurportin 1 0.0297 0.2027 0.571
Brugia malayi RE15519p 0.0049 0.0273 0.0737
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0273 0.0774
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0132 0.0102
Onchocerca volvulus 0.0049 0.0273 0.0138
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0273 0.0243
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0273 0.0737
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0273 0.0243
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0184 0.0441
Onchocerca volvulus 0.0091 0.0569 0.0438
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0273 0.0696
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0069 0.0319
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Entamoeba histolytica hypothetical protein 0.0023 0.0084 0.0349
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.0723
Entamoeba histolytica peptidase, C54 family 0.0046 0.0251 0.1048
Schistosoma mansoni ran 0.0021 0.0069 0.0195
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0113 0.0978
Plasmodium vivax hypothetical protein, conserved 0.003 0.0137 0.0926
Leishmania major GTP-binding protein, putative 0.0021 0.0069 0.023
Schistosoma mansoni hypothetical protein 0.0049 0.0273 0.0774
Schistosoma mansoni hypothetical protein 0.0049 0.0272 0.077
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.007 0.038
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0203 0.0805
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0132 0.0857 1
Onchocerca volvulus Phospholipase A2 homolog 0.1425 1 1
Loa Loa (eye worm) endoplasmin 0.0046 0.025 0.022
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0273 0.0696
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0298 0.1213
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0069 0.0112
Onchocerca volvulus 0.0035 0.0171 0.0034
Trypanosoma cruzi Emopamil binding protein, putative 0.0137 0.0893 0.3767
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0273 0.0696
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0163 0.0461
Echinococcus granulosus g protein coupled receptor 0.0049 0.0273 0.0696
Onchocerca volvulus 0.0049 0.0273 0.0138
Plasmodium falciparum importin beta, putative 0.0028 0.0121 0.1042
Schistosoma mansoni myosin xvIII 0.0049 0.0273 0.0774
Schistosoma mansoni opsin-like receptor 0.0049 0.0273 0.0774
Brugia malayi Melatonin receptor type 1A 0.0049 0.0273 0.0737
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.016 0.062
Trypanosoma brucei heat shock protein, putative 0.0046 0.025 0.1008
Onchocerca volvulus 0.0049 0.0273 0.0138
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0372
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0273 0.0696
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0121 0.0261
Brugia malayi jmjC domain containing protein 0.0099 0.0623 0.18
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0826 0.234
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0141 0.0586
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.1023 0.3014
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0273 0.0696
Brugia malayi putative neuropeptide receptor 0.0049 0.0273 0.0737
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.016 0.1064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0071 0.0238
Loa Loa (eye worm) hypothetical protein 0.0106 0.0675 0.0647
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0273 0.0696
Trypanosoma brucei Heat shock protein 83, putative 0.0046 0.025 0.1008
Plasmodium falciparum cysteine protease ATG4, putative 0.0046 0.0251 0.2166
Brugia malayi hypothetical protein 0.004 0.0205 0.053
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0161 0.0886
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0203 0.0575
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.0893 0.3767
Schistosoma mansoni inositol monophosphatase 0.0037 0.0184 0.0521
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0141 0.0317
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0107 0.0679 0.1969
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Onchocerca volvulus 0.0137 0.0893 0.0766
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0273 0.0774
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0298 0.2274
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0219 0.1472 0.6252
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0273 0.0696
Mycobacterium ulcerans heat shock protein 90 0.0043 0.023 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.016 0.1132
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0675 0.1958
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0763 0.4263
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0273 0.0696
Leishmania major importin beta-1 subunit, putative 0.0023 0.0084 0.0294
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0826 0.0798
Schistosoma mansoni neuropeptide receptor 0.0049 0.0273 0.0774
Brugia malayi Hsp90 protein 0.0031 0.0141 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0763 0.4263
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0121 0.0454
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.1023 0.0995
Plasmodium falciparum heat shock protein 90 0.0046 0.025 0.2155
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.006 0.0194
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0119 0.0763 0.4263
Schistosoma mansoni hypothetical protein 0.0297 0.2027 0.5746
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0273 0.0696
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0273 0.0774
Entamoeba histolytica peptidase, C54 family 0.0046 0.0251 0.1048
Echinococcus granulosus geminin 0.051 0.3528 1
Brugia malayi Endoplasmin precursor 0.0046 0.025 0.0667
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0273 0.0696
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0273 0.0696
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0071 0.004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Loa Loa (eye worm) hypothetical protein 0.0053 0.0298 0.0268
Brugia malayi G protein-coupled receptor 0.0049 0.0273 0.0737
Entamoeba histolytica peptidase, C54 family 0.0046 0.0251 0.1048
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0237 0.1744
Loa Loa (eye worm) inositol-1 0.0037 0.0184 0.0154
Brugia malayi sulfakinin receptor protein 0.0049 0.0273 0.0737
Brugia malayi follicle stimulating hormone receptor 0.0049 0.0273 0.0737
Schistosoma mansoni cpg binding protein 0.0096 0.0606 0.1718
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Schistosoma mansoni hypothetical protein 0.0049 0.0273 0.0774
Leishmania major hypothetical protein, conserved 0.0137 0.0893 0.3767
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0211 0.1821
Loa Loa (eye worm) hypothetical protein 0.0119 0.0763 0.0735
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0273 0.0243
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0372
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0093 0.0181
Trichomonas vaginalis heat shock protein, putative 0.0043 0.023 0.1275
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0119 0.0763 0.2164
Trypanosoma brucei heat shock protein, putative 0.0046 0.025 0.1008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0171 0.0485
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0137 0.0868
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0273 0.0696
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0273 0.0696
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0084 0.0455
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0273 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0121 0.0454
Trypanosoma cruzi Heat shock protein 83, putative 0.0046 0.025 0.1008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0069 0.0594
Echinococcus granulosus neuropeptide receptor 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0071 0.0008
Schistosoma mansoni heat shock protein 0.0031 0.0141 0.0398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0273 0.0774
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0273 0.0774
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0015 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Brugia malayi Peptidase family C54 containing protein 0.0119 0.0763 0.2226
Echinococcus multilocularis heat shock protein 90 0.0046 0.025 0.063
Leishmania major hypothetical protein, conserved 0.0053 0.0298 0.1213
Giardia lamblia DNA repair protein RAD52 0.035 0.2398 1
Onchocerca volvulus Phospholipase A2 homolog 0.0375 0.2574 0.2471
Brugia malayi hypothetical protein 0.0049 0.0273 0.0737
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Schistosoma mansoni hypothetical protein 0.0052 0.029 0.0822
Echinococcus multilocularis serotonin receptor 0.0049 0.0273 0.0696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0243
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0074 0.0638
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0273 0.0696
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0157 0.1035 0.4374
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0273 0.0696
Schistosoma mansoni hypothetical protein 0.004 0.0205 0.0581
Schistosoma mansoni biogenic amine receptor 0.0049 0.0273 0.0774
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.025 0.1008
Echinococcus granulosus allatostatin A receptor 0.0049 0.0273 0.0696
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0157 0.1035 0.4374
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0141 0.011
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0826 0.234
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0071 0.0295
Trypanosoma cruzi lanosterol synthase, putative 0.0198 0.1327 0.5628
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0272 0.0692
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0119 0.0763 0.2164
Brugia malayi G-protein coupled receptor 0.0049 0.0273 0.0737
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0273 0.0737
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0273 0.0696
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0273 0.0243
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0184 0.0441
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0273 0.0696
Brugia malayi ORL1-like opioid receptor 0.0049 0.0273 0.0737
Onchocerca volvulus 0.0049 0.0273 0.0138
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0273 0.0696
Schistosoma mansoni neuropeptide receptor 0.0049 0.0273 0.0774
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0219 0.0621
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.2027 0.2003
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0219 0.1472 0.6252
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0479 0.1358
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.038
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.025 0.1042
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.016 0.0372
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0273 0.0696
Schistosoma mansoni ap endonuclease 0.0021 0.0071 0.02
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0002 0.00000000016289
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0342 0.2346 0.7033
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0199 0.0513
Echinococcus multilocularis sex peptide receptor 0.0049 0.0273 0.0696
Treponema pallidum heat shock protein 90 0.0043 0.023 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0569 0.054
Schistosoma mansoni opsin-like receptor 0.0049 0.0273 0.0774
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.062
Schistosoma mansoni hypothetical protein 0.0452 0.3118 0.8838
Brugia malayi Pre-SET motif family protein 0.0232 0.1563 0.4655
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0095 0.0195
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0826 0.2276
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0043 0.023 1
Leishmania major heat shock protein 83-1 0.0046 0.025 0.1008
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0273 0.0696
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0184 0.0766
Schistosoma mansoni amine GPCR 0.0049 0.0273 0.0774
Echinococcus granulosus neuropeptide s receptor 0.0049 0.0273 0.0696
Schistosoma mansoni endoplasmin 0.0046 0.025 0.0709
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0273 0.0696
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0273 0.0737
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.0893 0.3767
Echinococcus granulosus heat shock protein 90 0.0046 0.025 0.063

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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