Detailed information for compound 891695

Basic information

Technical information
  • TDR Targets ID: 891695
  • Name: 2-(2,8-dimethyl-4-oxoquinolin-1-yl)-N-(3-meth ylphenyl)acetamide
  • MW: 320.385 | Formula: C20H20N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1c(C)cc(=O)c2c1c(C)ccc2)Nc1cccc(c1)C
  • InChi: 1S/C20H20N2O2/c1-13-6-4-8-16(10-13)21-19(24)12-22-15(3)11-18(23)17-9-5-7-14(2)20(17)22/h4-11H,12H2,1-3H3,(H,21,24)
  • InChiKey: HJTDCWCLADCBGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,8-dimethyl-4-oxo-1-quinolyl)-N-(3-methylphenyl)acetamide
  • 2-(4-keto-2,8-dimethyl-1-quinolyl)-N-(3-methylphenyl)acetamide
  • 2-(2,8-dimethyl-4-oxo-quinolin-1-yl)-N-(3-methylphenyl)ethanamide
  • STOCK3S-28814
  • ZINC00552275

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0421 0.1718 0.2066
Echinococcus multilocularis myotubularin protein 13 0.0082 0.0019 0.0001
Schistosoma mansoni kinase 0.0566 0.2446 0.4208
Trypanosoma cruzi p21-activated kinase 3, putative 0.0082 0.0019 0.0086
Echinococcus granulosus tyrosine kinase 0.0246 0.0843 0.0825
Schistosoma mansoni vav2 0.0143 0.0326 0.0531
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0222 0.072 0.3193
Giardia lamblia Kinase, NEK 0.0251 0.0864 0.3754
Echinococcus granulosus casein kinase I alpha 0.0116 0.0187 0.0168
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0211 0.0666 0.0704
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0293 0.1077 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0142 0.0321 0.1423
Onchocerca volvulus 0.0125 0.0235 0.0457
Echinococcus granulosus cyclin dependent kinase 5 0.0215 0.0684 0.0667
Schistosoma mansoni protein kinase 0.0084 0.0029 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Loa Loa (eye worm) sex muscle abnormal protein 5 0.011 0.0161 0.0155
Loa Loa (eye worm) AGC/AKT protein kinase 0.0533 0.2279 0.2457
Onchocerca volvulus 0.0132 0.0271 0.0528
Echinococcus multilocularis tyrosine protein kinase Abl 0.0339 0.1304 0.1562
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0491 0.2086
Trypanosoma cruzi cdc2-related kinase 3 0.0215 0.0684 0.3036
Echinococcus granulosus calcium activated potassium channel 0.0164 0.0428 0.041
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0332 0.127 0.1253
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.0209 0.0191
Echinococcus multilocularis tyrosine protein kinase shark 0.0125 0.0235 0.0262
Entamoeba histolytica protein kinase, putative 0.0114 0.0177 0.0658
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0321 0.0523
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Trichomonas vaginalis CK1 family protein kinase 0.0116 0.0187 0.0742
Schistosoma mansoni growth factor receptor-bound protein 0.011 0.0161 0.0246
Leishmania major protein kinase A catalytic subunit isoform 1 0.012 0.0209 0.0813
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0147 0.0344 0.0326
Entamoeba histolytica serine/threonine protein kinase, putative 0.0528 0.2255 0.9894
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0138 0.0297 0.0303
Trypanosoma cruzi Protein kinase B 0.0305 0.1134 0.5028
Echinococcus multilocularis 0.0359 0.1408 0.1688
Echinococcus granulosus protein kinase C gamma type 0.035 0.1364 0.1347
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Echinococcus multilocularis Immunoglobulin 0.0156 0.0392 0.0453
Entamoeba histolytica PH domain containing protein kinase, putative 0.0305 0.1134 0.4911
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0266 0.0939 0.1119
Plasmodium falciparum protein kinase, putative 0.0101 0.0115 0.0829
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0298 0.1102 0.1178
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0785 0.3539 0.3827
Echinococcus multilocularis epidermal growth factor receptor 0.1233 0.5786 0.7009
Echinococcus granulosus tyrosine protein kinase Fyn 0.0296 0.109 0.1073
Brugia malayi hypothetical protein 0.0125 0.0235 0.0234
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0156 0.0392 0.0646
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0187 0.0291
Leishmania major casein kinase, putative 0.0116 0.0187 0.0711
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0084 0.0029 0.0011
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0101 0.0115 0.0396
Echinococcus multilocularis mitogen activated protein kinase 3 0.0142 0.0321 0.0367
Schistosoma mansoni tyrosine kinase 0.0137 0.0292 0.0472
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0215 0.0684 0.2946
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0084 0.0029 0.0002
Leishmania major protein kinase, putative 0.0144 0.033 0.1356
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0084 0.0029 0.0005
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.0209 0.0232
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0246 0.0843 0.1001
Echinococcus multilocularis protein kinase shaggy 0.0235 0.0787 0.0933
Echinococcus granulosus epidermal growth factor receptor 0.0802 0.3628 0.3616
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Echinococcus granulosus aurora kinase A 0.027 0.0961 0.0944
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0368 0.1451 0.1435
Loa Loa (eye worm) hypothetical protein 0.0178 0.0498 0.0521
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0125 0.0235 0.0916
Schistosoma mansoni tyrosine kinase 0.0175 0.0482 0.0802
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0246 0.0843 0.0825
Loa Loa (eye worm) hypothetical protein 0.0228 0.0751 0.0796
Trichomonas vaginalis AGC family protein kinase 0.027 0.0961 0.4168
Echinococcus multilocularis tyrosine protein kinase Blk 0.0246 0.0843 0.1001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0296 0.109 0.1073
Plasmodium falciparum calcium-dependent protein kinase 2 0.0084 0.0029 0.0005
Echinococcus multilocularis aurora kinase A 0.027 0.0961 0.1145
Trypanosoma cruzi casein kinase, putative 0.0116 0.0187 0.0829
Trichomonas vaginalis AGC family protein kinase 0.0533 0.2279 1
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0205 0.0636 0.0671
Schistosoma mansoni serine/threonine protein kinase 0.0339 0.1307 0.2234
Trichomonas vaginalis AGC family protein kinase 0.0533 0.2279 1
Entamoeba histolytica protein kinase domain containing protein 0.0222 0.072 0.3073
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0084 0.0029 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Brugia malayi protein kinase C II. 0.0339 0.1307 0.14
Entamoeba histolytica casein kinase, putative 0.0116 0.0187 0.0704
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.0209 0.0232
Echinococcus granulosus Immunoglobulin 0.0156 0.0392 0.0374
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0266 0.0939 0.1001
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0293 0.1077 0.106
Schistosoma mansoni protein kinase 0.0147 0.0344 0.0564
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0084 0.0029 0.0013
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.011 0.0161 0.0246
Trichomonas vaginalis STE family protein kinase 0.0147 0.0344 0.1439
Plasmodium falciparum protein kinase 5 0.0215 0.0684 0.6259
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0293 0.1077 1
Entamoeba histolytica protein kinase 2, putative 0.0293 0.1077 0.4658
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0298 0.1102 0.4824
Echinococcus multilocularis c src tyrosine kinase 0.0175 0.0482 0.0563
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0296 0.109 0.1302
Trichomonas vaginalis CAMK family protein kinase 0.0528 0.2255 0.9895
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0029 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0785 0.3539 0.3527
Echinococcus multilocularis tyrosine protein kinase HCK 0.0185 0.0536 0.0629
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0902 0.4126 0.4991
Schistosoma mansoni tyrosine kinase 0.0802 0.3628 0.6258
Loa Loa (eye worm) hypothetical protein 0.0358 0.1401 0.1503
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0296 0.109 0.1302
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0084 0.0029 0.0013
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.044 0.1811 0.2179
Echinococcus granulosus tyrosine protein kinase Srms 0.0125 0.0235 0.0216
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0215 0.0684 0.2946
Echinococcus multilocularis N chimaerin 0.0132 0.0268 0.0304
Trichomonas vaginalis STE family protein kinase 0.0147 0.0344 0.1439
Brugia malayi Temporarily assigned gene name protein 59 0.0267 0.0945 0.1006
Echinococcus granulosus tyrosine kinase 0.0125 0.0235 0.0216
Entamoeba histolytica cell division protein kinase 2, putative 0.0215 0.0684 0.2915
Giardia lamblia Kinase, CMGC GSK 0.0235 0.0787 0.3406
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0266 0.0939 0.0923
Echinococcus multilocularis cyclin dependent kinase 0.0215 0.0684 0.0809
Echinococcus granulosus fibroblast growth factor receptor 4 0.0474 0.1984 0.1969
Onchocerca volvulus Serine\/threonine kinase homolog 0.0528 0.2255 0.4389
Giardia lamblia Kinase, NEK 0.0251 0.0864 0.3754
Trichomonas vaginalis AGC family protein kinase 0.0277 0.0997 0.4325
Trichomonas vaginalis AGC family protein kinase 0.0533 0.2279 1
Trypanosoma brucei protein kinase, putative 0.0142 0.0321 0.1299
Toxoplasma gondii AGC kinase 0.012 0.0209 0.0825
Plasmodium falciparum glycogen synthase kinase 3 0.0235 0.0787 0.7235
Echinococcus multilocularis casein kinase I alpha 0.0116 0.0187 0.0204
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0491 0.2086
Schistosoma mansoni protein kinase 0.0423 0.1727 0.2962
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0144 0.033 0.1465
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Echinococcus granulosus tyrosine protein kinase ABL1 0.0554 0.2385 0.2371
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0116 0.0187 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0421 0.1718 0.2946
Trichomonas vaginalis AGC family protein kinase 0.0266 0.0939 0.4073
Trypanosoma brucei cdc2-related kinase 3 0.0215 0.0684 0.2915
Schistosoma mansoni serine/threonine-protein kinase 0.0305 0.1134 0.1932
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.0684 0.1153
Schistosoma mansoni ste20-related kinase 0.0393 0.1579 0.2705
Onchocerca volvulus 0.0169 0.0454 0.0883
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0209 0.033
Brugia malayi Protein kinase domain containing protein 0.0897 0.4101 0.4437
Schistosoma mansoni tyrosine kinase 0.0474 0.1984 0.3407
Brugia malayi protein kinase C3,putative 0.028 0.1009 0.1076
Trichomonas vaginalis CK1 family protein kinase 0.0116 0.0187 0.0742
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0235 0.0787 0.0835
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0231 0.0764 0.0747
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0283 0.1028 0.1096
Echinococcus granulosus growth factor receptor bound protein 2 0.011 0.0161 0.0143
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0115 0.0183 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Echinococcus multilocularis serine threonine protein kinase 0.035 0.1364 0.1634
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.012 0.0209 0.0929
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0209 0.033
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0116 0.0187 0.0205
Loa Loa (eye worm) variant SH3 domain-containing protein 0.011 0.0161 0.0155
Loa Loa (eye worm) AGC/PKA protein kinase 0.012 0.0209 0.0207
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0099 0.0102 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.127 0.2168
Leishmania major casein kinase II, putative 0.0176 0.0491 0.2076
Trichomonas vaginalis CAMK family protein kinase 0.0528 0.2255 0.9895
Schistosoma mansoni serine/threonine-protein kinase 0.0305 0.1134 0.1932
Schistosoma mansoni serine/threonine protein kinase 0.0718 0.3206 0.5526
Entamoeba histolytica protein kinase, putative 0.0098 0.0101 0.032
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0132 0.0268 0.0304
Loa Loa (eye worm) hypothetical protein 0.0229 0.0755 0.08
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0142 0.0321 0.1423
Schistosoma mansoni vesicular amine transporter 0.0156 0.0392 0.0646
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0222 0.072 0.0762
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0142 0.0321 0.1423
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.044 0.1811 0.1796
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0297 0.1231
Entamoeba histolytica protein kinase, putative 0.0138 0.0297 0.1195
Echinococcus granulosus tyrosine protein kinase Btk29A 0.045 0.1865 0.185
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.045 0.1865 0.2243
Schistosoma mansoni serine/threonine protein kinase 0.0516 0.2192 0.3768
Brugia malayi serine/threonine-protein kinase plk-2 0.0528 0.2255 0.243
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.0684 0.1153
Giardia lamblia Kinase, AGC PKA 0.0293 0.1077 0.4708
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0235 0.0787 0.3489
Loa Loa (eye worm) hypothetical protein 0.0185 0.0533 0.0559
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.027 0.0961 0.1145
Brugia malayi p70 ribosomal S6 kinase beta 0.0522 0.2222 0.2394
Trichomonas vaginalis AGC family protein kinase 0.0533 0.2279 1
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0939 0.1596
Echinococcus multilocularis casein kinase i 0.0116 0.0187 0.0204
Giardia lamblia Kinase, CMGC CDK 0.0215 0.0684 0.2946
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.0764 0.1291
Echinococcus multilocularis cyclin dependent kinase 1 0.0215 0.0684 0.0809
Brugia malayi serine/threonine-protein kinase 6 0.027 0.0961 0.1024
Trypanosoma brucei polo-like protein kinase 0.0528 0.2255 0.9894
Echinococcus granulosus serine:threonine protein kinase 0.0205 0.0636 0.0618
Echinococcus granulosus serine:threonine protein kinase 0.0205 0.0636 0.0618
Entamoeba histolytica protein kinase, putative 0.027 0.0961 0.4144
Echinococcus granulosus cyclin dependent kinase 1 0.0215 0.0684 0.0667
Trichomonas vaginalis CAMK family protein kinase 0.0528 0.2255 0.9895
Trichomonas vaginalis STE family protein kinase 0.0102 0.012 0.0444
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0164 0.0428 0.0445
Loa Loa (eye worm) TK/EPH protein kinase 0.0233 0.0774 0.0821
Schistosoma mansoni protein kinase 0.0101 0.0115 0.0167
Trichomonas vaginalis STE family protein kinase 0.0251 0.0864 0.374
Brugia malayi serine/threonine-protein kinase PAK 7 0.0449 0.1859 0.2
Schistosoma mansoni protein kinase 0.0423 0.1727 0.2962
Giardia lamblia Kinase, CMGC GSK 0.0235 0.0787 0.3406
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Giardia lamblia Kinase, CMGC CK2 0.0176 0.0491 0.2076
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0474 0.1984 0.2388
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0522 0.2222 0.2395
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0939 0.1596
Brugia malayi Furin-like cysteine rich region family protein 0.1233 0.5786 0.6269
Loa Loa (eye worm) hypothetical protein 0.0132 0.0271 0.0275
Trichomonas vaginalis STE family protein kinase 0.0147 0.0344 0.1439
Trichomonas vaginalis CAMK family protein kinase 0.0528 0.2255 0.9895
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0235 0.0787 0.3406
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0215 0.0684 0.2991
Schistosoma mansoni tyrosine kinase 0.1233 0.5786 1
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Schistosoma mansoni ephrin receptor 0.0196 0.0592 0.0994
Echinococcus granulosus tyrosine protein kinase shark 0.0125 0.0235 0.0216
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0101 0.0115 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1263 0.5938 0.6435
Schistosoma mansoni protein kinase C mu 0.0277 0.0995 0.1693
Echinococcus multilocularis serine:threonine protein kinase 3 0.05 0.2115 0.2548
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.027 0.0961 0.4144
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0283 0.0458
Schistosoma mansoni protein kinase 0.0176 0.0491 0.0817
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0368 0.1451 0.1557
Echinococcus granulosus protein kinase c epsilon type 0.0339 0.1307 0.1291
Echinococcus granulosus mitogen activated protein kinase 0.0142 0.0321 0.0303
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0083 0.0023 0.0004
Trichomonas vaginalis AGC family protein kinase 0.027 0.0961 0.4168
Schistosoma mansoni tyrosine kinase 0.0401 0.1617 0.2771
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0083 0.0023 0.0005
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0235 0.0787 0.3457
Trichomonas vaginalis AGC family protein kinase 0.012 0.0209 0.0842
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0296 0.109 0.1302
Echinococcus granulosus dual specificity 0.0222 0.072 0.0703
Schistosoma mansoni serine/threonine protein kinase 0.0642 0.2823 0.4862
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0269 0.0954 0.1137
Echinococcus granulosus casein kinase i 0.0116 0.0187 0.0168
Trypanosoma brucei protein kinase, putative 0.0235 0.0787 0.337
Schistosoma mansoni serine/threonine protein kinase 0.0528 0.2255 0.3876
Onchocerca volvulus 0.0251 0.0866 0.1685
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0298 0.1102 0.4889
Echinococcus granulosus raf serine:threonine protein kinase 0.0135 0.0283 0.0265
Entamoeba histolytica protein kinase, putative 0.0114 0.0177 0.0658
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0332 0.127 0.152
Trichomonas vaginalis CAMK family protein kinase 0.0231 0.0763 0.3292
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0215 0.0684 0.0724
Loa Loa (eye worm) hypothetical protein 0.012 0.0209 0.0207
Echinococcus multilocularis tyrosine protein kinase Srms 0.0246 0.0843 0.1001
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0449 0.1859 0.2
Giardia lamblia Kinase, CMGC MAPK 0.0142 0.0321 0.1313
Brugia malayi phosphoinositide-dependent protein kinase I 0.0138 0.0297 0.0302
Echinococcus granulosus serine:threonine kinase SAD 1 0.0084 0.0029 0.001
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0283 0.1028 0.1097
Loa Loa (eye worm) hypothetical protein 0.0082 0.0019 0.0001
Onchocerca volvulus 0.0125 0.0235 0.0457
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Brugia malayi Cam kinase protein 1 0.0084 0.0029 0.0011
Echinococcus multilocularis mitogen activated protein kinase 11 0.0298 0.1102 0.1317
Echinococcus multilocularis epidermal growth factor receptor 0.0802 0.3628 0.4386
Echinococcus multilocularis raf serine:threonine protein kinase 0.0135 0.0283 0.0322
Echinococcus multilocularis mitogen activated protein kinase 14 0.0298 0.1102 0.1317
Brugia malayi SH2 domain containing protein 0.0125 0.0235 0.0234
Echinococcus multilocularis serine:threonine protein kinase 0.0205 0.0636 0.075
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0176 0.0491 0.0513
Entamoeba histolytica hypothetical protein 0.0222 0.072 0.3073
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0084 0.0029 0.0005
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0084 0.0029 0.0127
Echinococcus granulosus epidermal growth factor receptor 0.1233 0.5786 0.5778
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0296 0.109 0.1302
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0298 0.1102 0.4773
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.012 0.0209 0.1727
Brugia malayi Protein kinase domain containing protein 0.0164 0.0428 0.0445
Plasmodium falciparum calcium-dependent protein kinase 4 0.0084 0.0029 0.0005
Echinococcus multilocularis NCK adaptor protein 0.011 0.0161 0.0173
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0296 0.109 0.1073
Echinococcus multilocularis protein kinase c iota type 0.0508 0.2154 0.2595
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0215 0.0684 0.0667
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0474 0.1984 0.1969
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0554 0.2385 0.2875
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.012 0.0209 0.0207
Toxoplasma gondii aurora kinase 0.027 0.0961 0.4252
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0684 0.2944
Echinococcus multilocularis casein kinase I delta 0.0116 0.0187 0.0204
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0144 0.033 0.1342
Brugia malayi Protein kinase domain containing protein 0.0205 0.0636 0.067
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0147 0.0344 0.0326
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0101 0.0115 0.0386
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0182 0.0522 0.0611
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0116 0.0187 0.0205
Schistosoma mansoni protein kinase 0.0102 0.012 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0939 0.1596
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0082 0.0019 0.0001
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0251 0.0864 0.7974
Brugia malayi Hr1 repeat family protein 0.0266 0.0939 0.1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0293 0.1077 0.1285
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0116 0.0187 0.0169
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0084 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.0287 0.1046 0.1117
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0235 0.0787 0.1331
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0283 0.1028 0.1226
Loa Loa (eye worm) TK/ABL protein kinase 0.0554 0.2385 0.2572
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0228 0.0753 0.3246
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0144 0.033 0.1342
Echinococcus granulosus neuroglian 0.0191 0.0565 0.0547
Loa Loa (eye worm) hypothetical protein 0.0156 0.0392 0.0405
Brugia malayi Protein kinase domain containing protein 0.0266 0.0939 0.1
Schistosoma mansoni protein kinase 0.027 0.0961 0.1633
Echinococcus granulosus casein kinase I alpha 0.0116 0.0187 0.0168
Echinococcus granulosus tyrosine protein kinase Blk 0.0246 0.0843 0.0825
Entamoeba histolytica PH domain containing protein kinase, putative 0.0305 0.1134 0.4911
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0491 0.2086
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0235 0.0787 0.0933
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.0209 0.0191
Entamoeba histolytica protein kinase, putative 0.0116 0.0187 0.0705
Loa Loa (eye worm) AUR protein kinase 0.027 0.0961 0.1024
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.012 0.0209 0.0929
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0339 0.1307 0.1401
Leishmania major protein kinase, putative 0.0084 0.0029 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0533 0.2279 1
Echinococcus multilocularis mitogen activated protein kinase 0.0142 0.0321 0.0367
Brugia malayi Kinase associated domain 1 family protein 0.0126 0.0241 0.0241
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0138 0.0297 0.0339
Echinococcus granulosus Protein kinase C brain isozyme 0.0421 0.1718 0.1703
Echinococcus granulosus nervana 2 0.0256 0.089 0.0873
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Echinococcus granulosus myotubularin protein 13 0.0082 0.0019 0.0001
Schistosoma mansoni tyrosine kinase 0.0129 0.0254 0.0407
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0684 0.2944
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0043
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0147 0.0344 0.0396
Loa Loa (eye worm) TK/ROR protein kinase 0.0099 0.0102 0.0091
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0116 0.0187 0.0183
Loa Loa (eye worm) TK protein kinase 0.0185 0.0536 0.0563
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0516 0.2192 0.2363
Loa Loa (eye worm) hypothetical protein 0.011 0.0161 0.0155
Plasmodium falciparum casein kinase 2, alpha subunit 0.0176 0.0491 0.4409
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0115 0.0386
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0474 0.1984 0.2388
Brugia malayi Protein kinase domain containing protein 0.0368 0.1451 0.1557
Schistosoma mansoni serine/threonine kinase 0.0164 0.0428 0.0709
Echinococcus multilocularis rho associated protein kinase 0.0642 0.2823 0.3408
Echinococcus granulosus mitogen activated protein kinase 11 0.0298 0.1102 0.1086
Loa Loa (eye worm) hypothetical protein 0.0157 0.0394 0.0408
Plasmodium vivax casein kinase 1, putative 0.0116 0.0187 0.1511
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0368 0.1451 0.2825
Onchocerca volvulus 0.0125 0.0235 0.0457
Toxoplasma gondii CMGC kinase, CK2 family 0.0176 0.0491 0.2107
Echinococcus granulosus tyrosine protein kinase Lyn 0.0333 0.1277 0.1261
Trypanosoma cruzi casein kinase, putative 0.0116 0.0187 0.0829
Brugia malayi Protein kinase domain containing protein 0.0125 0.0235 0.0234
Echinococcus multilocularis nervana 2 0.0256 0.089 0.1058
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0158 0.0612
Giardia lamblia Kinase, STE STE20 0.0147 0.0344 0.1419
Echinococcus multilocularis casein kinase I alpha 0.0116 0.0187 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0297 0.0482
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0235 0.0787 0.0769
Trypanosoma cruzi casein kinase, putative 0.0116 0.0187 0.0829
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0491 0.2086
Brugia malayi SH2 domain containing protein 0.0125 0.0235 0.0234
Loa Loa (eye worm) AGC/PKA protein kinase 0.012 0.0209 0.0207
Echinococcus multilocularis serine:threonine protein kinase N2 0.0266 0.0939 0.1119
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0231 0.0764 0.0906
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0296 0.109 0.1073
Echinococcus granulosus NDR protein kinase 0.0266 0.0939 0.0923
Onchocerca volvulus 0.1005 0.4643 0.9038
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0222 0.072 0.3106
Echinococcus granulosus tyrosine protein kinase Src42A 0.0296 0.109 0.1073
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0283 0.1028 0.1011
Entamoeba histolytica protein kinase domain containing protein 0.0235 0.0787 0.337
Schistosoma mansoni serine/threonine protein kinase 0.0368 0.1451 0.2483
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0297 0.1231
Entamoeba histolytica protein kinase, putative 0.0102 0.012 0.0405
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0528 0.2255 0.2431
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0516 0.2192 0.2641
Onchocerca volvulus 0.0604 0.2637 0.5132
Plasmodium vivax unspecified product 0.0176 0.0491 0.4409
Echinococcus granulosus insulin receptor 0.0897 0.4101 0.409
Schistosoma mansoni serine/threonine protein kinase 0.044 0.1811 0.3108
Loa Loa (eye worm) TK/EGFR protein kinase 0.1233 0.5786 0.627
Plasmodium falciparum calcium-dependent protein kinase 1 0.0084 0.0029 0.0005
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0305 0.1134 0.5028
Echinococcus granulosus defective proboscis extension response 0.0156 0.0392 0.0374
Echinococcus granulosus tyrosine protein kinase HCK 0.0185 0.0536 0.0519
Echinococcus multilocularis ephrin type A receptor 4 A 0.0196 0.0592 0.0697
Echinococcus multilocularis hypothetical protein 0.0126 0.0241 0.0271
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0142 0.0321 0.1313
Brugia malayi SRC-1 0.0296 0.109 0.1164
Giardia lamblia Kinase, CMGC CDK 0.0215 0.0684 0.2946
Brugia malayi Protein kinase domain containing protein 0.0533 0.2279 0.2456
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.012 0.0209 0.0804
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0321 0.1335
Loa Loa (eye worm) hypothetical protein 0.0153 0.0374 0.0386
Echinococcus granulosus serine threonine protein kinase nrc 0.0293 0.1077 0.106
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0298 0.1102 0.4889
Echinococcus multilocularis mitogen activated protein kinase 14 0.0298 0.1102 0.1317
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0384 0.1534 0.1518
Onchocerca volvulus Tyrosine kinase homolog 0.1104 0.5138 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0029 0.0011
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0175 0.0482 0.0802
Entamoeba histolytica protein kinase, putative 0.0185 0.0536 0.2258
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0256 0.089 0.0873
Giardia lamblia Aurora kinase 0.027 0.0961 0.4189
Trichomonas vaginalis AGC family protein kinase 0.027 0.0961 0.4168
Giardia lamblia Kinase, AGC AKT 0.0211 0.0666 0.2866
Loa Loa (eye worm) TK protein kinase 0.0246 0.0843 0.0896
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0297 0.1231
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0277 0.0995 0.1061
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.012 0.0209 0.1727
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0633 0.2779 0.3001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0296 0.109 0.1073
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0084 0.0029 0.001
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0142 0.0321 0.1313
Brugia malayi Tyrosine-protein kinase abl-1 0.0339 0.1304 0.1397
Echinococcus granulosus cyclin dependent kinase 0.0215 0.0684 0.0667
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0084 0.0029 0.0012
Brugia malayi serine/threonine protein kinase 6 0.027 0.0961 0.1024
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0138 0.0297 0.0279
Echinococcus granulosus tyrosine protein kinase Src42A 0.0182 0.0522 0.0504
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0428 0.0709
Entamoeba histolytica protein kinase, putative 0.0087 0.0042 0.0061
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0368 0.1451 0.1557
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0144 0.033 0.1465
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0296 0.109 0.1302
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1918 0.9218 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0866 0.0921
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0266 0.0939 0.1119
Loa Loa (eye worm) AGC/PKN protein kinase 0.0266 0.0939 0.1001
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0222 0.072 0.3193
Schistosoma mansoni growth factor receptor-bound protein 0.011 0.0161 0.0246
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0147 0.0344 0.0396
Echinococcus multilocularis tyrosine kinase 0.0125 0.0235 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0029 0.0016
Brugia malayi ephrin receptor 1 precursor 0.0126 0.0241 0.0241
Trichomonas vaginalis CK1 family protein kinase 0.0116 0.0187 0.0742
Trypanosoma cruzi casein kinase, putative 0.0116 0.0187 0.0829
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0099 0.0102 0.0101
Echinococcus multilocularis myosin iiia 0.0144 0.033 0.0379
Onchocerca volvulus 0.0116 0.0187 0.0364
Brugia malayi Protein kinase domain containing protein 0.0138 0.0297 0.0302
Schistosoma mansoni cell adhesion molecule 0.0199 0.0606 0.1018
Entamoeba histolytica cell division protein kinase 2, putative 0.0215 0.0684 0.2915
Echinococcus granulosus N chimaerin 0.0132 0.0268 0.025
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0491 0.2086
Schistosoma mansoni serine/threonine protein kinase 0.0421 0.1718 0.2946
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0084 0.0029 0.0011
Entamoeba histolytica protein kinase, putative 0.0147 0.0344 0.1404
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0082 0.0019 0.0086
Echinococcus granulosus NCK adaptor protein 0.011 0.0161 0.0143
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0215 0.0684 0.0724
Echinococcus multilocularis Glutaredoxin protein 5 0.0256 0.089 0.1058
Schistosoma mansoni protein kinase 0.0147 0.0344 0.0564
Giardia lamblia Kinase, NEK 0.0251 0.0864 0.3754
Trichomonas vaginalis STE family protein kinase 0.0147 0.0344 0.1439
Schistosoma mansoni tyrosine kinase 0.0296 0.109 0.1857
Trypanosoma brucei Casein kinase II 0.0176 0.0491 0.2054
Loa Loa (eye worm) hypothetical protein 0.024 0.0809 0.0859
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0147 0.0344 0.0326
Toxoplasma gondii AGC kinase 0.012 0.0209 0.0825
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0718 0.3206 0.3465
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0132 0.0268 0.0432
Plasmodium falciparum calcium-dependent protein kinase 3 0.0084 0.0029 0.0005
Entamoeba histolytica protein kinase, putative 0.0266 0.0939 0.4049
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Schistosoma mansoni protein kinase 0.0084 0.0029 0.0017
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.012 0.0209 0.0804
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0084 0.0029 0.0011
Plasmodium vivax serine/threonine protein kinase 6, putative 0.027 0.0961 0.8898
Loa Loa (eye worm) hypothetical protein 0.0126 0.0241 0.0242
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0147 0.0344 0.0396
Loa Loa (eye worm) hypothetical protein 0.0084 0.0029 0.0011
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0116 0.0187 0.0183
Echinococcus multilocularis calcium activated potassium channel 0.0164 0.0428 0.0498
Loa Loa (eye worm) hypothetical protein 0.0287 0.1046 0.1117
Entamoeba histolytica casein kinase 1, putative 0.0116 0.0187 0.0704
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0156 0.0392 0.0646
Brugia malayi Protein kinase domain containing protein 0.0222 0.072 0.0762
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.127 0.2168
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0084 0.0029 0.001
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0132 0.0268 0.025
Entamoeba histolytica protein kinase, putative 0.0116 0.0187 0.0705
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0082 0.0019 0.0001
Toxoplasma gondii casein kinase I 0.0116 0.0187 0.0722
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0125 0.0235 0.0216
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0802 0.3628 0.3616
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0902 0.4126 0.4115
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0206 0.0641 0.0676
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.0417 0.0432
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Trypanosoma brucei casein kinase I, isoform 2 0.0116 0.0187 0.0704
Schistosoma mansoni hypothetical protein 0.0126 0.0241 0.0385
Loa Loa (eye worm) hypothetical protein 0.0161 0.0417 0.0433
Loa Loa (eye worm) hypothetical protein 0.0229 0.0755 0.08
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0332 0.127 0.1253
Brugia malayi cell division control protein 2 homolog 0.0215 0.0684 0.0723
Entamoeba histolytica protein kinase domain containing protein 0.0235 0.0787 0.337
Leishmania major protein kinase, putative 0.0101 0.0115 0.039
Trypanosoma cruzi cdc2-related kinase 1 0.0215 0.0684 0.3036
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0269 0.0954 0.0937
Onchocerca volvulus 0.0125 0.0235 0.0457
Entamoeba histolytica PH domain containing protein kinase, putative 0.0131 0.0267 0.1058
Echinococcus multilocularis mitogen activated protein kinase 11 0.0298 0.1102 0.1317
Schistosoma mansoni protein kinase 0.0084 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0185 0.0533 0.0559
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.0209 0.0232
Echinococcus granulosus rho-associated protein kinase 1 0.0642 0.2823 0.281
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0296 0.109 0.1302
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0235 0.0787 0.0835
Toxoplasma gondii AGC kinase 0.0522 0.2222 1
Loa Loa (eye worm) TK protein kinase 0.0509 0.2157 0.2325
Plasmodium vivax protein kinase Crk2 0.0215 0.0684 0.6259
Plasmodium vivax glycogen synthase kinase 3, putative 0.0235 0.0787 0.7235
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.012 0.0209 0.0929
Brugia malayi Protein kinase c protein 2 0.0193 0.0573 0.0602
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0084 0.0029 0.0011
Brugia malayi MAP kinase sur-1 0.0142 0.0321 0.0328
Onchocerca volvulus 0.0125 0.0235 0.0457
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0223 0.0723 0.3122
Brugia malayi Protein kinase domain containing protein 0.0125 0.0235 0.0234
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0785 0.3539 0.4278
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0142 0.0321 0.0328
Echinococcus multilocularis cyclin dependent kinase 1 0.0215 0.0684 0.0809
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0528 0.2255 0.2717
Entamoeba histolytica protein kinase, putative 0.0222 0.072 0.3073
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Echinococcus granulosus casein kinase I alpha 0.0116 0.0187 0.0168
Onchocerca volvulus 0.0091 0.0063 0.0122
Giardia lamblia Kinase, STE STE20 0.0144 0.033 0.1356
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0144 0.033 0.1342
Loa Loa (eye worm) SRC-1 0.0296 0.109 0.1165
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.0209 0.0191
Echinococcus granulosus serine:threonine protein kinase 12 B 0.027 0.0961 0.0944
Brugia malayi Protein kinase domain containing protein 0.0361 0.1417 0.1519
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Brugia malayi Sex muscle abnormal protein 5 0.011 0.0161 0.0154
Loa Loa (eye worm) hypothetical protein 0.0161 0.0417 0.0433
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Echinococcus granulosus mitogen activated protein kinase 3 0.0142 0.0321 0.0303
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0296 0.109 0.1302
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0084 0.0029 0.0002
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0256 0.089 0.1058
Brugia malayi Fibronectin type III domain containing protein 0.0161 0.0417 0.0432
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0084 0.0029 0.0013
Trypanosoma cruzi casein kinase II, putative 0.0176 0.0491 0.2176
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0122 0.0219 0.0217
Leishmania major protein kinase, putative 0.027 0.0961 0.4189
Trypanosoma brucei rac serine-threonine kinase, putative 0.0533 0.2279 1
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0029 0.0016
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0116 0.0187 0.0829
Trichomonas vaginalis AGC family protein kinase 0.0266 0.0939 0.4073
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.05 0.2115 0.2279
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0368 0.1451 0.1557
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0321 0.1335
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0098 0.0101 0.032
Echinococcus granulosus roundabout 2 0.0234 0.078 0.0763
Giardia lamblia Kinase, AGC PKA 0.012 0.0209 0.0813
Echinococcus multilocularis casein kinase I delta 0.0116 0.0187 0.0204
Brugia malayi Immunoglobulin I-set domain containing protein 0.1263 0.5938 0.6434
Echinococcus granulosus serine:threonine protein kinase 3 0.05 0.2115 0.2101
Plasmodium falciparum calcium-dependent protein kinase 5 0.0084 0.0029 0.0005
Schistosoma mansoni hypothetical protein 0.0126 0.0241 0.0385
Echinococcus multilocularis death associated protein kinase 1 0.1724 0.8248 1
Onchocerca volvulus 0.0642 0.2823 0.5496
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.044 0.1811 0.1949
Schistosoma mansoni adapter molecule crk 0.011 0.0161 0.0246
Echinococcus multilocularis nervana 2 0.0256 0.089 0.1058
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0491 0.2086
Trypanosoma cruzi casein kinase, putative 0.0116 0.0187 0.0829
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0176 0.0491 0.4409
Echinococcus granulosus casein kinase I delta 0.0116 0.0187 0.0168
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0384 0.1534 0.1841
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0116 0.0187 0.0169
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0029 0.0016
Echinococcus granulosus serine:threonine protein kinase N2 0.0266 0.0939 0.0923
Brugia malayi Casein kinase II, alpha chain 0.0176 0.0491 0.0512
Echinococcus multilocularis roundabout 2 0.0234 0.078 0.0925
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0684 0.2944
Trypanosoma cruzi polo-like protein kinase, putative 0.0528 0.2255 1
Trichomonas vaginalis STE family protein kinase 0.0144 0.033 0.1377
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0084 0.0029 0.0005
Echinococcus multilocularis insulin receptor 0.0897 0.4101 0.4961
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0215 0.0684 0.0724
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0142 0.0321 0.1423
Onchocerca volvulus 0.0235 0.0787 0.1531
Plasmodium falciparum casein kinase 1 0.0116 0.0187 0.1511
Loa Loa (eye worm) hypothetical protein 0.0156 0.0392 0.0405
Schistosoma mansoni nephrin 0.0196 0.059 0.099
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0266 0.0939 0.0923
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0296 0.109 0.1302
Leishmania major protein kinase A catalytic subunit 0.012 0.0209 0.0813
Trichomonas vaginalis AGC family protein kinase 0.027 0.0961 0.4168
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0187 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0533 0.2279 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0423 0.1727 0.2076
Trichomonas vaginalis CMGC family protein kinase 0.0235 0.0787 0.3397
Echinococcus multilocularis casein kinase ii subunit alpha 0.0176 0.0491 0.0574
Loa Loa (eye worm) hypothetical protein 0.0246 0.0841 0.0894
Brugia malayi Stress-activated protein kinase jnk-1 0.0516 0.2192 0.2362
Entamoeba histolytica protein kinase, putative 0.0222 0.072 0.3073
Echinococcus multilocularis rac serine:threonine kinase 0.0305 0.1134 0.1355
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0142 0.0321 0.1333
Echinococcus multilocularis PAK box P21 Rho binding 0.0102 0.012 0.0123
Loa Loa (eye worm) AUR protein kinase 0.027 0.0961 0.1024
Brugia malayi casein kinase 1, delta 0.0116 0.0187 0.0182
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0222 0.072 0.3073
Schistosoma mansoni tyrosine kinase 0.0493 0.2079 0.3571
Entamoeba histolytica protein kinase, putative 0.0533 0.2279 1
Echinococcus granulosus serine/threonine protein kinase 0.0305 0.1134 0.1117
Trichomonas vaginalis CAMK family protein kinase 0.0164 0.0428 0.181
Plasmodium falciparum NIMA related kinase 1 0.0251 0.0864 0.7974
Brugia malayi STE20-like kinase MST 0.05 0.2115 0.2279
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0084 0.0029 0.0002
Brugia malayi C1-like domain containing protein 0.0277 0.0995 0.1061
Loa Loa (eye worm) hypothetical protein 0.0553 0.2378 0.2565
Schistosoma mansoni tyrosine kinase 0.0897 0.4101 0.7078
Schistosoma mansoni tyrosine kinase 0.0802 0.3628 0.6258
Echinococcus granulosus protein kinase shaggy 0.0235 0.0787 0.0769
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.027 0.0961 0.4144
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.0764 0.1291
Giardia lamblia Kinase, PLK 0.0528 0.2255 1
Echinococcus granulosus Glutaredoxin protein 5 0.0256 0.089 0.0873
Onchocerca volvulus 0.024 0.0809 0.1574
Entamoeba histolytica protein kinase domain containing protein 0.0176 0.0491 0.2054
Brugia malayi Protein kinase domain containing protein 0.0125 0.0235 0.0234
Echinococcus granulosus activin receptor type 0.0101 0.0115 0.0097
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0296 0.109 0.1302
Schistosoma mansoni serine/threonine protein kinase 0.027 0.0961 0.1633
Echinococcus granulosus tyrosine protein kinase Src64B 0.0296 0.109 0.1073
Schistosoma mansoni serine/threonine kinase 0.0266 0.0939 0.1596
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0528 0.2255 0.224
Echinococcus multilocularis activin receptor type 0.0101 0.0115 0.0118
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0194 0.0581 0.0564
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0084 0.0029 0.0002
Brugia malayi serine/threonine kinase 12 0.027 0.0961 0.1024
Brugia malayi casein kinase I 0.0116 0.0187 0.0182
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.012 0.0209 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0509 0.2157 0.2324
Loa Loa (eye worm) hypothetical protein 0.011 0.0158 0.0151
Brugia malayi map kinase activated protein kinase protein 2 0.0785 0.3539 0.3827
Echinococcus multilocularis serine:threonine protein kinase N2 0.0266 0.0939 0.1119
Echinococcus granulosus nervana 2 0.0256 0.089 0.0873
Trypanosoma cruzi cdc2-related kinase 1 0.0215 0.0684 0.3036
Echinococcus granulosus c-Jun N-terminal kinases 0.0516 0.2192 0.2178
Entamoeba histolytica casein kinase, putative 0.0176 0.0491 0.2054
Brugia malayi Protein kinase domain containing protein 0.0266 0.0939 0.1
Echinococcus granulosus protein kinase c iota type 0.0508 0.2154 0.2139
Trypanosoma cruzi polo-like protein kinase, putative 0.0528 0.2255 1
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Echinococcus multilocularis dual specificity 0.0222 0.072 0.0852
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0101 0.0115 0.0512
Echinococcus multilocularis Immunoglobulin 0.0156 0.0392 0.0453
Brugia malayi Tyrosine-protein kinase abl-1 0.0265 0.0936 0.0996
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0084 0.0029 0.0127
Brugia malayi RhoGAP domain containing protein 0.0132 0.0268 0.0271
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.1028 0.1749
Trypanosoma brucei protein kinase, putative 0.0101 0.0115 0.0386
Echinococcus granulosus ephrin type A receptor 4 A 0.0196 0.0592 0.0575
Loa Loa (eye worm) hypothetical protein 0.0125 0.0235 0.0235
Echinococcus multilocularis neuroglian 0.0191 0.0565 0.0664
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0636 0.2729
Loa Loa (eye worm) AUR protein kinase 0.027 0.0961 0.1024
Brugia malayi intracellular kinase 0.0235 0.0787 0.0834
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0321 0.1335
Entamoeba histolytica protein kinase, putative 0.027 0.0961 0.4144
Echinococcus multilocularis cyclin dependent kinase 5 0.0215 0.0684 0.0809
Trypanosoma cruzi aurora B kinase, putative 0.027 0.0961 0.4262
Loa Loa (eye worm) hypothetical protein 0.0169 0.0454 0.0473
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0156 0.0392 0.0453
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0423 0.1727 0.1712
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0528 0.2255 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.011 0.0161 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0528 0.2255 0.9895
Onchocerca volvulus 0.0125 0.0235 0.0457
Brugia malayi Protein kinase domain containing protein 0.1918 0.9218 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.0209 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0321 0.1335
Trypanosoma brucei aurora B kinase 0.027 0.0961 0.4144
Schistosoma mansoni tyrosine kinase 0.0738 0.3307 0.5701
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.012 0.0209 0.0929
Trichomonas vaginalis AGC family protein kinase 0.0251 0.0864 0.374
Echinococcus multilocularis casein kinase I alpha 0.0116 0.0187 0.0204
Loa Loa (eye worm) hypothetical protein 0.0297 0.1096 0.1171
Brugia malayi hypothetical protein 0.0161 0.0417 0.0432
Schistosoma mansoni tyrosine kinase 0.0897 0.4101 0.7078
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.012 0.0209 0.0825
Brugia malayi Protein kinase domain containing protein 0.0215 0.0684 0.0723
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0491 0.2086
Echinococcus granulosus twitchin 0.0228 0.0752 0.0735
Entamoeba histolytica PH domain containing protein kinase, putative 0.0131 0.0267 0.1058
Entamoeba histolytica p21-activated kinase 0.0158 0.0402 0.1658
Echinococcus granulosus casein kinase ii subunit alpha 0.0176 0.0491 0.0473
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0368 0.1451 0.1741
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0084 0.0029 0.001
Loa Loa (eye worm) TK/INSR protein kinase 0.0897 0.4101 0.4438
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0292 0.1072 0.1145
Loa Loa (eye worm) hypothetical protein 0.0205 0.0636 0.0671
Echinococcus multilocularis serine:threonine protein kinase 0.0205 0.0636 0.075
Brugia malayi Variant SH3 domain containing protein 0.011 0.0161 0.0154
Brugia malayi Protein kinase domain containing protein 0.0125 0.0235 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0533 0.2279 1
Trypanosoma brucei cdc2-related kinase 1 0.0215 0.0684 0.2915
Giardia lamblia Kinase, CK1 Casein kinase 0.0116 0.0187 0.0711
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0277 0.0995 0.1062
Trichomonas vaginalis CAMK family protein kinase 0.0528 0.2255 0.9895
Trichomonas vaginalis CAMK family protein kinase 0.0231 0.0763 0.3292
Brugia malayi Protein kinase domain containing protein 0.0125 0.0235 0.0234
Loa Loa (eye worm) AGC/NDR protein kinase 0.0266 0.0939 0.1001
Schistosoma mansoni atypical protein kinase C 0.0521 0.2217 0.3811
Loa Loa (eye worm) TK/FER protein kinase 0.0125 0.0235 0.0235
Brugia malayi putative serine/threonine kinase SADA gamma 0.0084 0.0029 0.001
Schistosoma mansoni tyrosine kinase 0.0738 0.3307 0.5701
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0332 0.127 0.152
Schistosoma mansoni tyrosine kinase 0.0296 0.109 0.1857
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0501 0.0836
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0209 0.033
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0428 0.0709
Loa Loa (eye worm) hypothetical protein 0.0194 0.0581 0.0612
Plasmodium vivax calcium-dependent protein kinase, putative 0.0084 0.0029 0.0005
Echinococcus multilocularis serine:threonine protein kinase 38 0.0266 0.0939 0.1119
Entamoeba histolytica protein kinase, putative 0.0533 0.2279 1
Onchocerca volvulus 0.0287 0.1046 0.2037
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0138 0.0297 0.0303
Echinococcus granulosus mitogen activated protein kinase 14 0.0298 0.1102 0.1086
Leishmania major protein kinase A catalytic subunit isoform 2 0.012 0.0209 0.0813
Echinococcus granulosus casein kinase I delta 0.0116 0.0187 0.0168
Entamoeba histolytica protein kinase, putative 0.0235 0.0787 0.337
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0293 0.1077 0.4775
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.072 0.1215
Brugia malayi P38 map kinase family protein 2 0.0298 0.1102 0.1177
Trichomonas vaginalis CMGC family protein kinase 0.0235 0.0787 0.3397
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.027 0.0961 0.4144
Brugia malayi Variant SH3 domain containing protein 0.011 0.0161 0.0154
Schistosoma mansoni tyrosine kinase 0.0125 0.0235 0.0373
Brugia malayi Variant SH3 domain containing protein 0.0132 0.0268 0.0271
Loa Loa (eye worm) hypothetical protein 0.0287 0.1046 0.1117
Trichomonas vaginalis AGC family protein kinase 0.0266 0.0939 0.4073
Schistosoma mansoni serine/threonine protein kinase 0.0785 0.3539 0.6104
Entamoeba histolytica protein kinase, putative 0.0522 0.2222 0.9747
Brugia malayi protein-tyrosine kinase 0.0246 0.0843 0.0895
Plasmodium falciparum serine/threonine protein kinase, putative 0.027 0.0961 0.8898
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0132 0.0268 0.0272
Schistosoma mansoni protein kinase 0.0116 0.0187 0.0291
Echinococcus multilocularis protein kinase c epsilon type 0.0339 0.1307 0.1566
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0142 0.0321 0.1299
Trypanosoma cruzi cdc2-related kinase 3 0.0215 0.0684 0.3036
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0132 0.0268 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0029 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0528 0.2255 0.9895
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0251 0.0864 0.3811
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0428 0.0709
Loa Loa (eye worm) hypothetical protein 0.0169 0.0454 0.0473
Entamoeba histolytica protein kinase, putative 0.0084 0.0029 0.0002
Brugia malayi Protein kinase domain 0.0147 0.0344 0.0354
Brugia malayi Protein kinase domain containing protein 0.0354 0.1383 0.1482
Loa Loa (eye worm) hypothetical protein 0.0161 0.0417 0.0433
Schistosoma mansoni tyrosine kinase 0.0738 0.3307 0.5701
Brugia malayi Protein kinase domain containing protein 0.0718 0.3206 0.3464
Schistosoma mansoni tyrosine kinase 0.0175 0.0482 0.0802
Entamoeba histolytica protein kinase , putative 0.027 0.0961 0.4144
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0125 0.0235 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0029 0.0016
Echinococcus granulosus c src tyrosine kinase 0.0175 0.0482 0.0464
Schistosoma mansoni nck2/grb4 0.011 0.0161 0.0246
Entamoeba histolytica protein kinase domain containing protein 0.027 0.0961 0.4144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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