Detailed information for compound 892920

Basic information

Technical information
  • TDR Targets ID: 892920
  • Name: 4-(2-methoxy-5-methylphenyl)-4-oxobutanoic ac id
  • MW: 222.237 | Formula: C12H14O4
  • H donors: 1 H acceptors: 3 LogP: 1.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)CCC(=O)O)C
  • InChi: 1S/C12H14O4/c1-8-3-5-11(16-2)9(7-8)10(13)4-6-12(14)15/h3,5,7H,4,6H2,1-2H3,(H,14,15)
  • InChiKey: DAVYMGMWMJJLHA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-(2-methoxy-5-methyl-phenyl)-4-oxo-butanoic acid
  • 4-keto-4-(2-methoxy-5-methyl-phenyl)butyric acid
  • Oprea1_522932
  • ST5002199
  • BIM-0006327.P001
  • CBMicro_006356
  • Oprea1_580790
  • NSC171278
  • 4-(2-Methoxy-5-methyl-phenyl)-4-oxo-butyric acid
  • BAS 00406004

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0119 0.2978
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2253 1
Schistosoma mansoni atpase class VI type 11c 0.0008 0.0024 0.0107
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.0024 0.0045
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.2648
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0024 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0399 0.5689
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0701 1
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0201 0.2874
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.2543 1
Leishmania major P-type H -ATPase, putative 0.0008 0.0024 0.0345
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0024 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.1134
Trypanosoma cruzi P-type H+-ATPase, putative 0.0008 0.0024 0.0345
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0024 0.0045
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0119 0.0222
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.0597 0.0597
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0008 0.0024 0.0345
Trypanosoma cruzi hexose transporter 0.0039 0.0606 0.8651
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0582 0.2583
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0008 0.0024 0.0037
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0606 0.8651
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.006 0.1009 0.2677
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2253 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.0024 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Treponema pallidum cation-transporting ATPase, P-type 0.0008 0.0024 0.0045
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0399 0.5689
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Brugia malayi major facilitator superfamily protein 0.0018 0.0201 0.0535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.5346 1
Echinococcus granulosus General substrate transporter 0.0108 0.1918 0.851
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0024 0.0107
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0008 0.0024 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Brugia malayi hypothetical protein 0.0018 0.0201 0.0535
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.3768 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0377
Leishmania major hypothetical protein, conserved 0.0018 0.0201 0.2874
Plasmodium falciparum mitogen-activated protein kinase 2 0.0203 0.3724 0.3724
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0201 0.0305
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.0535
Loa Loa (eye worm) hypothetical protein 0.0096 0.1686 0.4473
Loa Loa (eye worm) hypothetical protein 0.0032 0.0482 0.1279
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.2648
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0038 0.0597 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0597 0.2648
Leishmania major calcium-translocating P-type ATPase 0.0008 0.0024 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0008 0.0024 0.0095
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0161 0.0428
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0399 0.0746
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0008 0.0024 0.0107
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0201 0.0792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.5346 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0024 0.0045
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0008 0.0024 0.0107
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0038 0.0597 0.8517
Trypanosoma cruzi P-type H+-ATPase, putative 0.0008 0.0024 0.0345
Schistosoma mansoni protein kinase 0.0038 0.0597 0.2648
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0399 0.1769
Onchocerca volvulus 0.0018 0.0201 0.0414
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 1
Schistosoma mansoni transient receptor potential channel 0.0063 0.1069 0.4746
Trypanosoma brucei cation-transporting ATPase, putative 0.0008 0.0024 0.0345
Trypanosoma brucei glucose transporter 2A 0.0039 0.0606 0.8651
Plasmodium falciparum copper-transporting ATPase 0.0008 0.0024 0.0024
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0008 0.0024 0.0345
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.0024 0.0107
Schistosoma mansoni hypothetical protein 0.0034 0.0505 0.2239
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.08 0.2124
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0701 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.5346 1
Schistosoma mansoni ATPase 0.0008 0.0024 0.0107
Schistosoma mansoni hypothetical protein 0.0016 0.0161 0.0716
Echinococcus granulosus cation transporting ATPase 13A3 0.0008 0.0024 0.0107
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0201 0.0894
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0552 0.2448
Onchocerca volvulus 0.0018 0.0201 0.0414
Echinococcus granulosus copper transporting ATPase 1 0.0008 0.0024 0.0107
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0505 0.1339
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0201 0.0792
Onchocerca volvulus 0.0018 0.0201 0.0414
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0582 0.2583
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.016 0.0424
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.0894
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0008 0.0024 0.0095
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Loa Loa (eye worm) hypothetical protein 0.0049 0.08 0.2124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.5346 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0203 0.3724 0.3724
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0008 0.0024 0.0095
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0333 0.0623
Schistosoma mansoni glucose transport protein 0.0125 0.2253 1
Onchocerca volvulus 0.0018 0.0201 0.0414
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0201 0.0377
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0161 0.0716
Toxoplasma gondii protein kinase, putative 0.0354 0.6612 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.5346 1
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0008 0.0024 0.0095
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.1686 0.748
Loa Loa (eye worm) hypothetical protein 0.0087 0.1518 0.4028
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0008 0.0024 0.0045
Schistosoma mansoni hypothetical protein 0.0016 0.0161 0.0716
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0008 0.0024 0.0064
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.1686 0.748
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0008 0.0024 0.0345
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0008 0.0024 0.0095
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.08 0.2124
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0024 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.5346 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0582 0.2583
Loa Loa (eye worm) calcium ATPase 0.0008 0.0024 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Brugia malayi major facilitator superfamily protein 0.0018 0.0201 0.0535
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0399 0.1568
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.0024 0.0045
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0064
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0582 0.1545
Leishmania major copper-transporting ATPase-like protein, putative 0.0008 0.0024 0.0345
Toxoplasma gondii facilitative glucose transporter GT1 0.0125 0.2253 0.3408
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0201 0.2874
Entamoeba histolytica protein kinase, putative 0.0038 0.0597 0.1116
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0399 0.1568
Toxoplasma gondii P-type ATPase PMA1 0.0008 0.0024 0.0037
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0024 0.0045
Onchocerca volvulus 0.0018 0.0201 0.0414
Plasmodium vivax calcium-transporting ATPase, putative 0.0008 0.0024 0.0024
Plasmodium falciparum calcium-dependent protein kinase 4 0.0038 0.0597 0.0597
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0543 0.2408
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0201 0.0535
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0425 0.1888
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0606 0.1134
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0606 0.1134
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0024 0.0107
Trichomonas vaginalis set domain proteins, putative 0.0233 0.4307 0.8057
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0024 0.0107
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0024 0.0107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.08 0.2124
Plasmodium vivax sugar transporter, putative 0.0018 0.0201 0.0201
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0161 0.0716
Loa Loa (eye worm) hypothetical protein 0.0036 0.0543 0.144
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Echinococcus multilocularis General substrate transporter 0.0108 0.1918 0.851
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0425 0.1888
Onchocerca volvulus 0.0018 0.0201 0.0414
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0008 0.0024 0.0345
Onchocerca volvulus 0.0018 0.0201 0.0414
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.0024 0.0107
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0008 0.0024 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Trypanosoma cruzi proton motive ATPase 1, putative 0.0008 0.0024 0.0345
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0008 0.0024 0.0045
Giardia lamblia Hexose transporter 0.0018 0.0201 0.0377
Leishmania major proton motive ATPase, putative 0.0008 0.0024 0.0345
Loa Loa (eye worm) hypothetical protein 0.0038 0.0582 0.1545
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0038 0.0597 0.0903
Giardia lamblia Copper-transporting P-type ATPase 0.0008 0.0024 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0582 0.2289
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0008 0.0024 0.0045
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0201 0.0792
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0582 0.1089
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0377
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0038 0.0597 0.0903
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0038 0.0597 0.1584
Echinococcus granulosus cation transporting atpase worm 0.0008 0.0024 0.0107
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0399 0.1058
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0008 0.0024 0.0045
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.0894
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0008 0.0024 0.0045
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0038 0.0597 0.0597
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0008 0.0024 0.0345
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0008 0.0024 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Loa Loa (eye worm) E1-E2 ATPase 0.0008 0.0024 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0425 0.1888
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0425 0.1888
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0161 0.0428
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.2648
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0543 0.2408
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Schistosoma mansoni glucose transport protein 0.0125 0.2253 1
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0008 0.0024 0.0345
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.2543 1
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0399 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.1625 0.7211
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0582 0.2583
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0201 0.2874
Brugia malayi hypothetical protein 0.0087 0.1518 0.4028
Trypanosoma brucei sugar transporter, putative 0.0018 0.0201 0.2874
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0399 0.5689
Schistosoma mansoni eyes absent homolog 0.0087 0.1518 0.6736
Toxoplasma gondii cation-transporting atpase family protein 0.0008 0.0024 0.0037
Brugia malayi Na,K-ATPase alpha subunit 0.0008 0.0024 0.0064
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0008 0.0024 0.0107
Onchocerca volvulus 0.0018 0.0201 0.0414
Brugia malayi Sugar transporter family protein 0.0018 0.0201 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0377
Toxoplasma gondii sugar transporter ST2 0.0018 0.0201 0.0305
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Plasmodium falciparum calcium-dependent protein kinase 1 0.0038 0.0597 0.0597
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0399 0.1769
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0024 0.0045
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Loa Loa (eye worm) hypothetical protein 0.0087 0.1518 0.4028
Mycobacterium ulcerans sugar transporter 0.0018 0.0201 0.0792
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Trypanosoma brucei P-type H+-ATPase, putative 0.0008 0.0024 0.0345
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0008 0.0024 0.0095
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0582 0.1089
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0377
Schistosoma mansoni hypothetical protein 0.0016 0.0161 0.0716
Entamoeba histolytica protein kinase, putative 0.0038 0.0597 0.1116
Brugia malayi hypothetical protein 0.0018 0.0201 0.0535
Onchocerca volvulus 0.0018 0.0201 0.0414
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Brugia malayi Sugar transporter family protein 0.0125 0.2253 0.5981
Echinococcus multilocularis GPCR, family 2 0.0016 0.0161 0.0716
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Loa Loa (eye worm) sugar transporter 0.0125 0.2253 0.5981
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0038 0.0597 0.2648
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0399 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0377
Plasmodium vivax copper-transporting ATPase, putative 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.0024 0.0045
Trypanosoma cruzi cation-transporting ATPase, putative 0.0008 0.0024 0.0345
Schistosoma mansoni protein kinase 0.0038 0.0597 0.2648
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.1069 0.4746
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0701 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0008 0.0024 0.0095
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0008 0.0024 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2253 1
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.0535
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0008 0.0024 0.0095
Onchocerca volvulus 0.0018 0.0201 0.0414
Onchocerca volvulus 0.0029 0.0425 0.0937
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0024 0.0045
Brugia malayi Pre-SET motif family protein 0.0029 0.0425 0.1129
Plasmodium falciparum hexose transporter 0.0125 0.2253 0.2253
Plasmodium vivax P-type ATPase4, putative 0.0008 0.0024 0.0024
Schistosoma mansoni transient receptor potential channel 0.0063 0.1069 0.4746
Toxoplasma gondii sugar transporter ST1 0.0018 0.0201 0.0305
Loa Loa (eye worm) hypothetical protein 0.0038 0.0582 0.1545
Plasmodium vivax hexose transporter 0.0125 0.2253 0.2253
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0008 0.0024 0.0345
Echinococcus granulosus cation transporting ATPase 13A1 0.0008 0.0024 0.0107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0038 0.0597 0.1584
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0582 0.1089
Schistosoma mansoni hypothetical protein 0.0016 0.0161 0.0716
Plasmodium vivax cation transporting ATPase, putative 0.0008 0.0024 0.0024
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0008 0.0024 0.0045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0161 0.0716
Onchocerca volvulus 0.0018 0.0201 0.0414
Schistosoma mansoni copper ABC transporter ATPase 0.0008 0.0024 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.1134
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0064
Echinococcus multilocularis cation transporting ATPase 13A3 0.0008 0.0024 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Brugia malayi Pre-SET motif family protein 0.0205 0.3768 1
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0024 0.0064
Brugia malayi Cam kinase protein 1 0.0038 0.0597 0.1584
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0428
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.5346 1
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.1686 0.748
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0606 0.1134
Schistosoma mansoni glucose transport protein 0.0125 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Plasmodium falciparum calcium-dependent protein kinase 3 0.0038 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0701 0.106
Trypanosoma brucei P-type H+-ATPase, putative 0.0008 0.0024 0.0345
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0425 0.1888
Echinococcus multilocularis cation transporting atpase worm 0.0008 0.0024 0.0107
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0405 0.1796
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0701 0.0701
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0008 0.0024 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0161 0.0428
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0201 0.0792
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0008 0.0024 0.0064
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0008 0.0024 0.0095
Plasmodium falciparum protein kinase 7 0.0354 0.6612 0.6612
Echinococcus granulosus GPCR family 2 0.0016 0.0161 0.0716
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Chlamydia trachomatis metal transport ATPase 0.0008 0.0024 0.0606
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.0024 0.0045
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0008 0.0024 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2253 0.4215
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0038 0.0597 0.0903
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0008 0.0024 0.0107
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0008 0.0024 0.0045
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0201 0.0535
Entamoeba histolytica hypothetical protein 0.0028 0.0399 0.0746
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0201 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0425 0.1888
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0543 0.144
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0125 0.2253 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.5346 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0399 0.1058
Toxoplasma gondii sugar transporter ST3 0.0018 0.0201 0.0305
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2253 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.5346 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0399 0.0399
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0201 0.0894
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0008 0.0024 0.0107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.2648
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0008 0.0024 0.0345
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0203 0.3724 0.5632
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0024 0.0107
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0201 0.2874
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0008 0.0024 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0008 0.0024 0.0095
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0582 0.1545
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0064
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0552 0.2448
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.0038 0.0597 0.1584
Onchocerca volvulus 0.0018 0.0201 0.0414
Echinococcus multilocularis copper transporting ATPase 1 0.0008 0.0024 0.0107
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0008 0.0024 0.0107
Treponema pallidum hypothetical protein 0.0008 0.0024 0.0045
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0008 0.0024 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Loa Loa (eye worm) hypothetical protein 0.0029 0.0425 0.1129
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0318 0.1252
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0024 0.0045
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.0024 0.0045
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.2648
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 1
Leishmania major glucose transporter, lmgt1 0.0039 0.0606 0.8651
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0597 0.1116
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0024 0.0064
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0201 0.0201
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0008 0.0024 0.0045
Trypanosoma cruzi copper-transporting ATPase, putative 0.0008 0.0024 0.0345
Leishmania major protein kinase, putative 0.0038 0.0597 0.8517
Toxoplasma gondii P-type ATPase4, putative 0.0008 0.0024 0.0037
Echinococcus multilocularis cation transporting ATPase 13A1 0.0008 0.0024 0.0107
Leishmania major P-type H -ATPase, putative 0.0008 0.0024 0.0345
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.0535
Trypanosoma cruzi hexose transporter, putative 0.0021 0.027 0.386
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.2648
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0119 0.0467
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0008 0.0024 0.0095
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.1069 0.4746
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0399 0.0746
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0038 0.0597 0.1584
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0318 0.1252
Schistosoma mansoni glucose transporter 0.0018 0.0201 0.0894
Schistosoma mansoni transient receptor potential channel 0.0096 0.1686 0.748
Plasmodium vivax SET domain protein, putative 0.0029 0.0425 0.0425
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.0894
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.1625 0.7211
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0024 0.0045
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2253 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.2648
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0008 0.0024 0.0037
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0008 0.0024 0.0045
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2253 1
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0201 0.0377
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0894
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0008 0.0024 0.0095
Trypanosoma brucei glucose transporter 1E 0.0039 0.0606 0.8651
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0318 0.1252
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0024 0.0045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0425 0.0643
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0399 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.1134
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0399 0.1769
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0201 0.0894
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0024 0.0045
Plasmodium vivax calcium-dependent protein kinase, putative 0.0038 0.0597 0.0597
Leishmania major glucose transporter, lmgt3 0.0039 0.0606 0.8651
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0606 0.1134
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0399 0.1769
Brugia malayi hypothetical protein 0.0018 0.0201 0.0535
Onchocerca volvulus 0.0233 0.4307 1
Giardia lamblia Sugar-proton symporter 0.0018 0.0201 0.0377
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Brugia malayi hypothetical protein 0.0008 0.0024 0.0064
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Loa Loa (eye worm) sugar transporter 0.0018 0.0201 0.0535
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0008 0.0024 0.0095
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.1069 0.4746
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0008 0.0024 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0425 0.1888
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Leishmania major glucose transporter, lmgt2 0.0039 0.0606 0.8651
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0008 0.0024 0.0037
Plasmodium falciparum calcium-dependent protein kinase 5 0.0038 0.0597 0.0597
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.0024 0.0107
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0064
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0024 0.0064
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.5346 1
Onchocerca volvulus 0.0018 0.0201 0.0414
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0505 0.1339
Loa Loa (eye worm) hypothetical protein 0.0031 0.0448 0.1188
Onchocerca volvulus 0.0018 0.0201 0.0414
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0008 0.0024 0.0045
Onchocerca volvulus 0.0018 0.0201 0.0414
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0008 0.0024 0.0345
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0008 0.0024 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0161 0.0716
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0008 0.0024 0.0095
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0008 0.0024 0.0037
Schistosoma mansoni protein kinase 0.0038 0.0597 0.2648
Plasmodium falciparum calcium-dependent protein kinase 2 0.0038 0.0597 0.0597
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0008 0.0024 0.0037
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0024 0.0107
Schistosoma mansoni ATPase 0.0008 0.0024 0.0107
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0008 0.0024 0.0095
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0201 0.0377
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0008 0.0024 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0008 0.0024 0.0345
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0008 0.0024 0.0095
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.5346 1
Onchocerca volvulus Putative transporter 0.0018 0.0201 0.0414
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0008 0.0024 0.0345
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.1069 0.4746
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.2543 1
Schistosoma mansoni cation-transporting ATPase 0.0008 0.0024 0.0107
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0024 0.0107
Schistosoma mansoni hypothetical protein 0.0125 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0377
Onchocerca volvulus 0.0018 0.0201 0.0414
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0399 0.1568
Plasmodium vivax CDK-related protein kinase 6, putative 0.0532 1 1
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0024 0.0107
Brugia malayi Sugar transporter family protein 0.0018 0.0201 0.0535
Schistosoma mansoni type V p-type atpase isoform 0.0008 0.0024 0.0107
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0535
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0201 0.0792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.5346 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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