Detailed information for compound 893663

Basic information

Technical information
  • TDR Targets ID: 893663
  • Name: ZINC01144726
  • MW: 404.083 | Formula: C16H13BrCl2O3
  • H donors: 0 H acceptors: 1 LogP: 5.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C=O)cc(c1OCc1c(Cl)cccc1Cl)Br
  • InChi: 1S/C16H13BrCl2O3/c1-2-21-15-7-10(8-20)6-12(17)16(15)22-9-11-13(18)4-3-5-14(11)19/h3-8H,2,9H2,1H3
  • InChiKey: WERFWZZIVYKAEP-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ets 0.0011 0.0249 0.0296
Entamoeba histolytica hypothetical protein 0.0037 0.1223 0.3535
Trypanosoma cruzi glyoxalase II 0.0016 0.0459 0.0526
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0459 0.0292
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0459 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0459 0.1078
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0249 0.0147
Schistosoma mansoni ferritin 0.0009 0.0172 0.0202
Schistosoma mansoni gabp alpha 0.0074 0.2617 0.3166
Schistosoma mansoni hypothetical protein 0.0016 0.0459 0.055
Echinococcus multilocularis expressed protein 0.0009 0.0172 0.0059
Brugia malayi Muscleblind-like protein 0.0153 0.5561 0.6246
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.1262 0.1301
Onchocerca volvulus Huntingtin homolog 0.0125 0.4534 0.7884
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.1262 0.2675
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0183 0.0184
Entamoeba histolytica hypothetical protein 0.0037 0.1223 0.3535
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3461 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.2617 0.2928
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0459 0.0386
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0158 0.0157
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0158 0.0044
Trichomonas vaginalis A-type flavoprotein 0.0016 0.0459 0.1078
Trypanosoma cruzi glyoxalase II 0.0016 0.0459 0.0526
Loa Loa (eye worm) hypothetical protein 0.0153 0.5561 0.6246
Brugia malayi hypothetical protein 0.0037 0.1223 0.1357
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0249 0.0259
Schistosoma mansoni smad1 5 8 and 0.0008 0.0158 0.0186
Loa Loa (eye worm) hypothetical protein 0.0016 0.0459 0.0495
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.3461 0.3878
Schistosoma mansoni hypothetical protein 0.0016 0.0459 0.055
Echinococcus granulosus muscleblind protein 0.0153 0.5561 0.6202
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0698 0.0916
Echinococcus granulosus ferritin 0.0009 0.0172 0.0059
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0459 0.1078
Loa Loa (eye worm) hypothetical protein 0.0154 0.5627 0.632
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.051 0.0444
Entamoeba histolytica hypothetical protein 0.0012 0.0292 0.0844
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0459 0.1326
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0459 0.1326
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.1223 0.1258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0447 0.0482
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0459 0.1078
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0459 0.1326
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0249 0.0259
Schistosoma mansoni cpg binding protein 0.0029 0.0946 0.114
Entamoeba histolytica hypothetical protein 0.0037 0.1223 0.3535
Echinococcus granulosus kelch ECH associated protein 1 like 0.0097 0.346 0.3807
Mycobacterium ulcerans glyoxalase II, GloB 0.0016 0.0459 0.0292
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.2097 0.2253
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0459 0.0495
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0447 0.0482
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0158 0.0186
Mycobacterium ulcerans hypothetical protein 0.0016 0.0459 0.0292
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.1262 0.1301
Leishmania major metallo-beta-lactamase family protein-like protein 0.0016 0.0459 0.0038
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.1262 0.1523
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0249 0.0147
Trypanosoma brucei polo-like protein kinase 0.0097 0.3461 0.7155
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0447 0.0489
Schistosoma mansoni hypothetical protein 0.0016 0.0459 0.055
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0459 0.1326
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1692 0.1885
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0447 0.0536
Brugia malayi hypothetical protein 0.0016 0.0459 0.0495
Echinococcus multilocularis ETHE1 protein 0.0016 0.0459 0.0386
Plasmodium vivax unspecified product 0.0016 0.0459 1
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.216 0.2325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.012 0.014
Echinococcus multilocularis kelch ECH associated protein 1 0.0097 0.346 0.3807
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.1262 0.219
Chlamydia trachomatis ribonuclease Z 0.0016 0.0459 0.5
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0459 0.0526
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.4414 0.4953
Schistosoma mansoni apoferritin-2 0.0009 0.0172 0.0202
Schistosoma mansoni hypothetical protein 0.0037 0.1223 0.1477
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.3461 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0459 0.0386
Echinococcus multilocularis smad 0.0008 0.0158 0.0044
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0459 0.1078
Brugia malayi transcription factor E74 isoform 0.0011 0.0249 0.0259
Echinococcus multilocularis Smad4 0.0008 0.0158 0.0044
Brugia malayi jmjC domain containing protein 0.0016 0.0447 0.0482
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.2097 0.2253
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0016 0.0459 0.0386
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.1262 0.306
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0459 0.1078
Entamoeba histolytica hypothetical protein 0.0037 0.1223 0.3535
Onchocerca volvulus 0.0049 0.1692 0.2386
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.1223 0.1258
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0459 0.0292
Schistosoma mansoni ferritin 0.0009 0.0172 0.0202
Schistosoma mansoni jumonji domain containing protein 0.006 0.2097 0.2535
Trypanosoma cruzi glyoxalase II 0.0016 0.0459 0.0526
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0158 0.0044
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0249 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3461 1
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0447 0.0536
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0459 0.1326
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.051 0.0444
Brugia malayi jmjC domain containing protein 0.006 0.2097 0.2341
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.216 0.2611
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0459 0.0386
Mycobacterium tuberculosis Conserved protein 0.0016 0.0459 0.0292
Echinococcus multilocularis cpg binding protein 0.0031 0.1008 0.1013
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0447 0.0482
Schistosoma mansoni ets-related 0.0011 0.0249 0.0296
Schistosoma mansoni cpg binding protein 0.0031 0.1008 0.1216
Mycobacterium ulcerans hypothetical protein 0.0016 0.0459 0.0292
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0016 0.0459 0.0495
Loa Loa (eye worm) hypothetical protein 0.0011 0.0249 0.0259
Schistosoma mansoni hypothetical protein 0.0011 0.0249 0.0296
Mycobacterium ulcerans hypothetical protein 0.0016 0.0459 0.0292
Leishmania major hypothetical protein, conserved 0.0023 0.0698 0.0832
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0016 0.0459 0.0078
Echinococcus multilocularis ferritin 0.0009 0.0172 0.0059
Loa Loa (eye worm) hypothetical protein 0.0063 0.2216 0.2475
Echinococcus multilocularis Kelch repeat type 1 0.0097 0.347 0.3819
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.216 0.2611
Brugia malayi hypothetical protein 0.0125 0.4534 0.5087
Mycobacterium tuberculosis Conserved protein 0.0016 0.0459 0.0292
Echinococcus granulosus protein C ets 2 0.0011 0.0249 0.0147
Brugia malayi jmjC domain containing protein 0.0016 0.0447 0.0482
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0249 0.0147
Onchocerca volvulus Huntingtin homolog 0.0125 0.4534 0.7884
Schistosoma mansoni ferritin light chain 0.0009 0.0172 0.0202
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0459 0.055
Mycobacterium ulcerans hydrolase 0.0016 0.0459 0.0292
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0271 1 1
Echinococcus multilocularis kelch ECH associated protein 1 0.0097 0.346 0.3807
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0459 0.1078
Brugia malayi MH1 domain containing protein 0.0008 0.0158 0.0157
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0249 0.0147
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.013 0.4721 0.4628
Schistosoma mansoni smad 0.0008 0.0158 0.0186
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.013 0.4721 1
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0459 0.0292
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0459 0.0526
Brugia malayi hypothetical protein 0.0154 0.5627 0.632
Mycobacterium tuberculosis Conserved protein 0.0016 0.0459 0.0292
Echinococcus multilocularis protein C ets 2 0.0011 0.0249 0.0147
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.1262 0.1301
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.3461 1
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0459 0.0631
Loa Loa (eye worm) hypothetical protein 0.0016 0.0459 0.0495
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0016 0.0459 0.0495
Loa Loa (eye worm) hypothetical protein 0.0125 0.4534 0.5087
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0447 0.0536
Brugia malayi Smad1 0.0008 0.0158 0.0157
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0459 0.1078
Mycobacterium leprae POSSIBLE HYDROLASE 0.0016 0.0459 0.0631
Leishmania major hypothetical protein, conserved 0.0016 0.0459 0.0038
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0016 0.0459 0.0292
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.1223 0.1477
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0249 0.0296
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0016 0.0459 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0459 0.1078
Schistosoma mansoni ferritin 0.0009 0.0172 0.0202
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0016 0.0459 0.0495
Echinococcus multilocularis ets variant gene 4 0.0011 0.0249 0.0147
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0249 0.0259
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0249 0.0147
Echinococcus granulosus cpg binding protein 0.0031 0.1008 0.1013
Brugia malayi jmjC domain containing protein 0.0016 0.0447 0.0482
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.1262 0.3646
Loa Loa (eye worm) hypothetical protein 0.0071 0.2507 0.2804
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1636 0.4577
Trypanosoma brucei glyoxalase II 0.0016 0.0459 0.0376
Brugia malayi Ets-domain containing protein 0.0074 0.2617 0.2928
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0459 0.1078
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1636 0.4577
Entamoeba histolytica hypothetical protein 0.0012 0.0292 0.0844
Treponema pallidum ribonuclease Z 0.0016 0.0459 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0459 0.0386
Echinococcus granulosus smad 0.0008 0.0158 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0459 0.1078
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0459 0.0526
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0459 0.1326
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0187 0.0076
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.2097 0.2253
Onchocerca volvulus 0.0029 0.0946 0.0942
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0447 0.0536
Loa Loa (eye worm) Smad1 0.0008 0.0158 0.0157
Schistosoma mansoni kinase 0.0049 0.1684 0.2034
Schistosoma mansoni ferritin 0.0009 0.0172 0.0202
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0447 0.0373
Schistosoma mansoni tsg101-related 0.0048 0.1657 0.2002
Loa Loa (eye worm) hypothetical protein 0.0038 0.1262 0.14
Schistosoma mansoni hypothetical protein 0.0049 0.1692 0.2045
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.1262 0.2703
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0459 0.0292
Echinococcus granulosus expressed protein 0.0009 0.0172 0.0059
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.1262 0.1301
Schistosoma mansoni cpg binding protein 0.0031 0.1008 0.1216
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0447 0.0489
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.3461 0.5808
Schistosoma mansoni survival motor neuron protein 0.0049 0.1692 0.2045
Mycobacterium leprae Beta-lactamase-like protein 0.0016 0.0459 0.0631
Brugia malayi MH2 domain containing protein 0.0122 0.4414 0.4953
Schistosoma mansoni tsg101-related 0.0059 0.2062 0.2493
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0447 0.0373
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0447 0.0373
Schistosoma mansoni hypothetical protein 0.0011 0.0249 0.0296
Entamoeba histolytica hypothetical protein 0.0012 0.0292 0.0844
Schistosoma mansoni hypothetical protein 0.0097 0.347 0.4199
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1929 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.1262 0.1301
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0187 0.0189
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.1262 0.1523
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0016 0.0459 0.0386
Leishmania major metallo-beta-lactamase family-like protein 0.0016 0.0459 0.0038
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0016 0.0459 0.0495
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.3461 1
Brugia malayi ethe1-prov protein 0.0016 0.0459 0.0495
Echinococcus multilocularis muscleblind protein 0.0153 0.5561 0.6202
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0016 0.0459 0.0038
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0016 0.0459 0.0078
Brugia malayi Fli-1 protein 0.0225 0.8257 0.9284
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.3461 0.3808
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.2177 0.2633
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0187 0.0076
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0459 0.1326
Giardia lamblia Kinase, PLK 0.0097 0.3461 1
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0459 0.1326
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0292 0.0583
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0459 0.1078
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.1262 0.14
Brugia malayi MH2 domain containing protein 0.0008 0.0158 0.0157
Echinococcus multilocularis zinc phosphodiesterase 0.0016 0.0459 0.0386
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0459 0.0526
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0249 0.0147
Mycobacterium ulcerans hydrolase 0.0016 0.0459 0.0292
Loa Loa (eye worm) hypothetical protein 0.0153 0.5561 0.6246
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0158 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3461 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1262 0.3465
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0016 0.0459 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0459 0.1078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0459 0.0495
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.216 0.2412
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0698 0.1281
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0447 0.0482
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3461 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0158 0.0044
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0016 0.0459 0.055
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.1262 0.1301
Echinococcus granulosus Smad4 0.0008 0.0158 0.0044
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0447 0.0373
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0016 0.0459 0.0038
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0459 0.0495
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3461 1
Echinococcus granulosus ETHE1 protein 0.0016 0.0459 0.0386
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.1262 0.306
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0249 0.0259
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0459 0.1326
Mycobacterium ulcerans hypothetical protein 0.0016 0.0459 0.0292
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0158 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0249 0.0259
Mycobacterium tuberculosis Beta lactamase like protein 0.0016 0.0459 0.0292
Loa Loa (eye worm) fli-1 protein 0.0225 0.8257 0.9284
Brugia malayi hypothetical protein 0.0071 0.2507 0.2804
Brugia malayi Ets-domain containing protein 0.0074 0.2617 0.2928
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.2617 0.2847
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0946 0.1044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0447 0.0482
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0249 0.0147
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.3461 0.3878
Brugia malayi jmjC domain containing protein 0.0016 0.0447 0.0482
Mycobacterium ulcerans beta lactamase-like protein 0.0016 0.0459 0.0292
Mycobacterium ulcerans lipoprotein LpqF 0.013 0.4721 0.4628
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.2507 0.2721
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3461 1
Schistosoma mansoni ferritin light chain 0.0009 0.0172 0.0202
Brugia malayi jmjC domain containing protein 0.0062 0.216 0.2412
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0459 0.0631
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0459 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.3461 0.4188
Trypanosoma brucei beta lactamase 0.013 0.4721 1
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0249 0.0147
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.2617 0.2847
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0016 0.0459 0.0376
Schistosoma mansoni tsg101-related 0.0059 0.2062 0.2493
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.1262 0.3465
Mycobacterium ulcerans hydrolase 0.0016 0.0459 0.0292
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0459 0.1326
Loa Loa (eye worm) hypothetical protein 0.0016 0.0447 0.0482
Brugia malayi MH2 domain containing protein 0.0008 0.0158 0.0157
Entamoeba histolytica hypothetical protein 0.0012 0.0292 0.0844
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.4414 0.4953
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0447 0.0373
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0447 0.035
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0459 0.0526
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0447 0.0536
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0459 0.055
Schistosoma mansoni smad1 5 8 and 0.0008 0.0158 0.0186
Trichomonas vaginalis hypothetical protein 0.0035 0.1143 0.3111
Loa Loa (eye worm) hypothetical protein 0.0016 0.0459 0.0495
Brugia malayi CXXC zinc finger family protein 0.0029 0.0946 0.1044
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0249 0.0147
Plasmodium falciparum cytosolic glyoxalase II 0.0016 0.0459 1
Brugia malayi MH1 domain containing protein 0.0008 0.0158 0.0157
Schistosoma mansoni apoferritin-2 0.0009 0.0172 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0292 0.0583
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0249 0.0147
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0249 0.0259
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0016 0.0459 1
Schistosoma mansoni Smad4 0.0008 0.0158 0.0186
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0249 0.0147
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0447 0.0373
Schistosoma mansoni ets-related 0.0225 0.8257 1
Brugia malayi hypothetical protein 0.0242 0.8893 1
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.2507 0.2721
Brugia malayi Ets-domain containing protein 0.0011 0.0249 0.0259
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.8893 1
Echinococcus multilocularis muscleblind protein 1 0.0153 0.5561 0.6202
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0447 0.0373
Schistosoma mansoni elf1 0.0011 0.0249 0.0296
Trichomonas vaginalis ferritin, putative 0.0009 0.0172 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0459 0.1078
Echinococcus granulosus phd:f box containing protein 0.0016 0.0447 0.0373
Onchocerca volvulus 0.0154 0.5627 1
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0016 0.0459 0.0376
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.1262 0.3465
Echinococcus granulosus zinc phosphodiesterase 0.0016 0.0459 0.0386
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.3461 0.3808
Loa Loa (eye worm) hypothetical protein 0.0242 0.8893 1
Echinococcus granulosus kelch ECH associated protein 1 like 0.0097 0.346 0.3807
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.1657 0.4787
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.8893 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3461 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.4534 0.5087
Echinococcus granulosus kelch ECH associated protein 1 0.0097 0.346 0.3807
Schistosoma mansoni smad1 5 8 and 0.0008 0.0158 0.0186
Trichomonas vaginalis apoptosis inducing factor, putative 0.0016 0.0459 0.1078
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.3461 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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