Detailed information for compound 900512

Basic information

Technical information
  • TDR Targets ID: 900512
  • Name: 4-[2-(2,3-dihydroindol-1-yl)-2-oxoethoxy]-3-e thoxybenzaldehyde
  • MW: 325.358 | Formula: C19H19NO4
  • H donors: 0 H acceptors: 2 LogP: 2.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C=O)ccc1OCC(=O)N1CCc2c1cccc2
  • InChi: 1S/C19H19NO4/c1-2-23-18-11-14(12-21)7-8-17(18)24-13-19(22)20-10-9-15-5-3-4-6-16(15)20/h3-8,11-12H,2,9-10,13H2,1H3
  • InChiKey: YKYHXHSGSLCTQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-ethoxy-4-(2-indolin-1-yl-2-oxo-ethoxy)benzaldehyde
  • 3-ethoxy-4-[2-(1-indolinyl)-2-oxoethoxy]benzaldehyde
  • 3-ethoxy-4-(2-indolin-1-yl-2-keto-ethoxy)benzaldehyde
  • 4-[2-(2,3-dihydroindol-1-yl)-2-oxo-ethoxy]-3-ethoxy-benzaldehyde
  • ZINC00796145
  • 4-[2-(2,3-Dihydro-indol-1-yl)-2-oxo-ethoxy]-3-ethoxy-benzaldehyde
  • BAS 05889274

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0099 0.039 0.0645
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0002 0.0005
Echinococcus multilocularis purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Brugia malayi MTAP 0.0855 0.4775 0.5251
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0847 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0195 0.0215
Loa Loa (eye worm) hypothetical protein 0.0036 0.0026 0.0028
Echinococcus granulosus SET and MYND domain containing protein 3 0.0077 0.0266 0.044
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0099 0.039 0.0645
Echinococcus multilocularis purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0237 0.1193 0.1312
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0002 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.0343 0.0567
Echinococcus granulosus purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Brugia malayi PHD-finger family protein 0.0032 0.0002 0.0002
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0655 0.3619 0.5982
Loa Loa (eye worm) hypothetical protein 0.0986 0.5537 0.609
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0424 0.0701
Schistosoma mansoni hypothetical protein 0.0057 0.0148 0.0309
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0158 0.0735 0.1214
Trypanosoma brucei histone-lysine n-methyltransferase 0.0099 0.039 0.0645
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0424 0.0701
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0037 0.0032 0.0053
Onchocerca volvulus 0.0303 0.1576 0.1575
Mycobacterium ulcerans spermidine synthase 0.0847 0.473 0.9889
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0319 0.1669 0.2755
Echinococcus granulosus PWWP domain containing protein 2A 0.0091 0.0343 0.0567
Echinococcus multilocularis purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Echinococcus granulosus protein arginine N methyltransferase 8 0.0034 0.0012 0.002
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0443 0.2385 0.3941
Loa Loa (eye worm) spermidine synthase 0.1074 0.605 0.6654
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0091 0.0343 0.0567
Echinococcus granulosus purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Echinococcus multilocularis PWWP domain containing protein 2A 0.0091 0.0343 0.0567
Brugia malayi jmjC domain containing protein 0.0105 0.0424 0.0467
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0036 0.0026 0.0043
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.0735 0.0735
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0855 0.4775 0.5251
Brugia malayi PWWP domain containing protein 0.0091 0.0343 0.0377
Trypanosoma brucei uridine phosphorylase 0.0158 0.0735 0.1214
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0052 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1599 0.9092 1
Plasmodium vivax spermidine synthase, putative 0.1074 0.605 1
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0855 0.4775 1
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0036 0.0026 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0237 0.1193 0.2498
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0655 0.3619 0.5982
Echinococcus multilocularis microtubule associated protein 2 0.0761 0.4234 0.6998
Echinococcus granulosus purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Loa Loa (eye worm) hypothetical protein 0.0124 0.0537 0.0591
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0034 0.0012 0.002
Schistosoma mansoni methylthioadenosine phosphorylase 0.0855 0.4775 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0172 0.0814 0.1345
Onchocerca volvulus 0.029 0.15 0.1498
Echinococcus granulosus metastasis associated protein 1 mta1 0.0036 0.0026 0.0043
Leishmania major S-adenosylmethionine decarboxylase 0.0655 0.3619 0.5982
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0443 0.2385 0.4994
Echinococcus granulosus peregrin 0.0123 0.0529 0.0874
Echinococcus multilocularis peregrin 0.0123 0.0529 0.0874
Loa Loa (eye worm) CXXC zinc finger family protein 0.0303 0.1576 0.1734
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0158 0.0735 0.0733
Treponema pallidum uridine phosphorylase (udp) 0.0158 0.0735 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0002 0.0004
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.016 0.0742 0.1227
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0034 0.0012 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0052 0.0108
Echinococcus granulosus cpg binding protein 0.0305 0.1587 0.2623
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0158 0.0735 1
Schistosoma mansoni purine nucleoside phosphorylase 0.0158 0.0735 0.1539
Loa Loa (eye worm) hypothetical protein 0.0779 0.4334 0.4767
Brugia malayi polybromodomain protein 0.0036 0.0026 0.0028
Schistosoma mansoni purine nucleoside phosphorylase 0.0158 0.0735 0.1539
Schistosoma mansoni hypothetical protein 0.0032 0.0002 0.0005
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0158 0.0735 0.1214
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0158 0.0735 0.3081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0026 0.0028
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.0735 0.0735
Mycobacterium leprae probable uridine phosphorylase 0.0158 0.0735 0.5
Onchocerca volvulus 0.0128 0.0559 0.0557
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0036 0.0026 0.0054
Schistosoma mansoni SET domain protein 0.0108 0.0443 0.0928
Leishmania major histone-lysine N-methyltransferase, putative 0.0099 0.039 0.0645
Schistosoma mansoni suppressor of variegation 4-20-related 0.0151 0.069 0.1446
Brugia malayi Bromodomain containing protein 0.0032 0.0002 0.0002
Chlamydia trachomatis AMP nucleosidase 0.0158 0.0735 0.5
Echinococcus granulosus spermidine synthase 0.1074 0.605 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Echinococcus granulosus disco interacting protein 2 0.0312 0.1628 0.2692
Plasmodium falciparum purine nucleoside phosphorylase 0.0158 0.0735 0.1211
Brugia malayi hypothetical protein 0.0091 0.0343 0.0377
Trypanosoma cruzi spermidine synthase, putative 0.1074 0.605 1
Schistosoma mansoni cpg binding protein 0.0303 0.1576 0.3302
Echinococcus multilocularis uridine phosphorylase 1 0.0158 0.0735 0.1214
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0036 0.0026 0.0043
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0065 0.0195 0.0323
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0855 0.4775 0.7892
Toxoplasma gondii hypothetical protein 0.0686 0.3797 1
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0655 0.3619 0.398
Brugia malayi Carm1-pending protein 0.016 0.0742 0.0816
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0855 0.4775 0.7892
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.004
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0158 0.0735 0.3081
Trypanosoma brucei transcription elongation factor s-II, putative 0.0091 0.0343 0.0567
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.0735 0.0735
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0158 0.0735 0.3081
Schistosoma mansoni cpg binding protein 0.0305 0.1587 0.3324
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0093 0.0356 0.0584
Loa Loa (eye worm) hypothetical protein 0.0362 0.1918 0.211
Brugia malayi SET domain containing protein 0.0053 0.0126 0.0138
Schistosoma mansoni histone J3 methyltransferase 0.0779 0.4334 0.9077
Trypanosoma cruzi spermidine synthase, putative 0.1074 0.605 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0158 0.0735 1
Schistosoma mansoni hypothetical protein 0.0186 0.0895 0.1874
Toxoplasma gondii hypothetical protein 0.0099 0.039 0.1028
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0319 0.1669 0.2755
Loa Loa (eye worm) Carm1-pending protein 0.016 0.0742 0.0816
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0172 0.0814 0.2143
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0025
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0686 0.3797 0.6274
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.0735 0.0735
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0075 0.0124
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0034 0.0012 0.0016
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0655 0.3619 0.5982
Echinococcus granulosus metastasis associated protein MTA1 0.0036 0.0026 0.0043
Schistosoma mansoni bromo adjacent homology domain containing 0.0036 0.0026 0.0054
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0099 0.039 0.0645
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0041 0.0068
Leishmania major hypothetical protein, conserved 0.0099 0.039 0.0645
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0036 0.0026 0.0054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0002
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0099 0.039 0.0645
Loa Loa (eye worm) hypothetical protein 0.0055 0.0135 0.0148
Echinococcus granulosus polybromo 1 0.0036 0.0026 0.0043
Toxoplasma gondii hypothetical protein 0.0091 0.0343 0.0904
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0036 0.0026 0.0043
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0002 0.0002
Brugia malayi SET domain containing protein 0.0151 0.069 0.0759
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0855 0.4775 0.7892
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0065 0.0195 0.0323
Brugia malayi hypothetical protein 0.0362 0.1918 0.211
Echinococcus granulosus protein arginine methyltransferase 0.0034 0.0012 0.002
Echinococcus granulosus geminin 0.0186 0.0895 0.1479
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.02 0.022
Echinococcus multilocularis hepatoma derived growth factor protein 0.0091 0.0343 0.0567
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0312 0.1628 0.3411
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Echinococcus granulosus purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0158 0.0735 0.5
Echinococcus granulosus hepatoma derived growth factor protein 0.0091 0.0343 0.0567
Loa Loa (eye worm) hypothetical protein 0.0362 0.1918 0.211
Echinococcus multilocularis metastasis associated protein MTA1 0.0036 0.0026 0.0043
Echinococcus granulosus PWWP domain containing protein 2A 0.0091 0.0343 0.0567
Schistosoma mansoni hypothetical protein 0.0186 0.0895 0.1874
Schistosoma mansoni enhancer of zeste ezh 0.0313 0.1633 0.3421
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0313 0.1633 0.27
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0655 0.3619 0.5982
Brugia malayi Pre-SET motif family protein 0.0209 0.1029 0.1132
Echinococcus granulosus microtubule associated protein 2 0.0761 0.4234 0.6998
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0655 0.3619 0.398
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0106 0.0433 0.0715
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0037 0.0032 0.0053
Schistosoma mansoni microtubule-associated protein tau 0.0761 0.4234 0.8868
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.029 0.15 0.3141
Leishmania major hypothetical protein, conserved 0.0099 0.039 0.0645
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0091 0.0343 0.0567
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0091 0.0343 0.0567
Brugia malayi GATA zinc finger family protein 0.0036 0.0026 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0237 0.1193 0.2498
Toxoplasma gondii phosphorylase family protein 0.0158 0.0735 0.1935
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0158 0.0735 0.0808
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0443 0.2385 0.3939
Echinococcus multilocularis histone h3 methyltransferase 0.0779 0.4334 0.7163
Echinococcus multilocularis spermidine synthase 0.1074 0.605 1
Loa Loa (eye worm) hypothetical protein 0.0362 0.1918 0.211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0172 0.0814 0.1704
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0099 0.039 0.0645
Schistosoma mansoni hypothetical protein 0.0036 0.0026 0.0054
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.016 0.0742 0.1955
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0696 0.3857 0.7815
Brugia malayi SET domain containing protein 0.0134 0.0592 0.0651
Onchocerca volvulus 0.0091 0.0343 0.0341
Echinococcus multilocularis polybromo 1 0.0036 0.0026 0.0043
Echinococcus granulosus purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Echinococcus granulosus uridine phosphorylase 1 0.0158 0.0735 0.1214
Loa Loa (eye worm) hypothetical protein 0.0075 0.0255 0.028
Brugia malayi uridine phosphorylase family protein 0.0158 0.0735 0.0808
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0151 0.069 0.1141
Onchocerca volvulus 0.0091 0.0343 0.0341
Loa Loa (eye worm) SET domain-containing protein 0.0313 0.1633 0.1797
Trichomonas vaginalis set domain proteins, putative 0.1755 1 1
Schistosoma mansoni cpg binding protein 0.0305 0.1587 0.3324
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0034 0.0012 0.0016
Brugia malayi Pre-SET motif family protein 0.1599 0.9092 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.0735 0.0735
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0052 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.0735 0.0735
Echinococcus multilocularis purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Loa Loa (eye worm) hypothetical protein 0.0036 0.0026 0.0028
Brugia malayi hypothetical protein 0.0065 0.0195 0.0215
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0036 0.0026 0.0043
Treponema pallidum pfs protein (pfs) 0.0158 0.0735 0.5
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.0735 0.0735
Echinococcus multilocularis purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0158 0.0735 0.1214
Giardia lamblia UPL-1 0.0158 0.0735 1
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0099 0.039 0.0645
Brugia malayi NNMT/PNMT/TEMT family protein 0.0986 0.5537 0.609
Loa Loa (eye worm) hypothetical protein 0.0312 0.1628 0.1791
Toxoplasma gondii DNA methyltransferase 2, putative 0.0443 0.2385 0.6281
Entamoeba histolytica hypothetical protein 0.0091 0.0343 0.1439
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0855 0.4775 0.7892
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0002 0.0004
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0093 0.0356 0.0584
Loa Loa (eye worm) SET domain-containing protein 0.0151 0.069 0.0759
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0052 0.0085
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0655 0.3619 0.5982
Toxoplasma gondii Purine nucleoside phosphorylase 0.0158 0.0735 0.1935
Plasmodium falciparum spermidine synthase 0.1074 0.605 1
Brugia malayi CXXC zinc finger family protein 0.0303 0.1576 0.1734
Schistosoma mansoni hypothetical protein 0.0091 0.0343 0.0719
Echinococcus multilocularis disco interacting protein 2 0.0312 0.1628 0.2692
Echinococcus granulosus methylthioadenosine phosphorylase 0.0855 0.4775 0.7892
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0036 0.0026 0.0054
Brugia malayi hypothetical protein 0.0091 0.0343 0.0377
Onchocerca volvulus 0.0362 0.1918 0.1917
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.0343 0.0567
Echinococcus granulosus histone arginine methyltransferase CARMER 0.016 0.0742 0.1227
Toxoplasma gondii phosphorylase family protein 0.0158 0.0735 0.1935
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0075 0.025 0.0659
Schistosoma mansoni protein arginine n-methyltransferase 0.016 0.0742 0.1554
Echinococcus granulosus bromo adjacent y domain containing 1 0.0036 0.0026 0.0043
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0158 0.0735 0.3081
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0025
Leishmania major hypothetical protein, conserved 0.0091 0.0343 0.0567
Brugia malayi SET domain containing protein 0.0313 0.1633 0.1797
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0158 0.0735 0.3081
Trichomonas vaginalis origin recognition complex subunit, putative 0.0036 0.0026 0.0026
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0075 0.0124
Leishmania major nucleoside phosphorylase-like protein 0.0158 0.0735 0.1214
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0158 0.0735 1
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0986 0.5537 0.609
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0443 0.2385 0.3941
Echinococcus granulosus purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Loa Loa (eye worm) hypothetical protein 0.0091 0.0343 0.0377
Echinococcus granulosus histone h3 methyltransferase 0.0779 0.4334 0.7163
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0779 0.4334 0.4767
Schistosoma mansoni polybromo-1 0.0036 0.0026 0.0054
Trypanosoma cruzi spermidine synthase, putative 0.1074 0.605 1
Brugia malayi ELM2 domain containing protein 0.0036 0.0026 0.0028
Echinococcus multilocularis cpg binding protein 0.0305 0.1587 0.2623
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0655 0.3619 0.5982
Echinococcus granulosus histone lysine methyltransferase setb 0.0237 0.1193 0.1972
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0443 0.2385 1
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0158 0.0735 0.5
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0299 0.0627
Loa Loa (eye worm) hypothetical protein 0.0037 0.0032 0.0035
Schistosoma mansoni hepatoma derived growth factor 0.0091 0.0343 0.0719
Echinococcus multilocularis geminin 0.0186 0.0895 0.1479
Schistosoma mansoni hypothetical protein 0.0091 0.0343 0.0719
Echinococcus multilocularis protein arginine methyltransferase 0.0034 0.0012 0.002
Echinococcus granulosus purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Leishmania major modification methylase-like protein 0.0443 0.2385 0.3941
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.0735 0.0735
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0065 0.0195 0.0819
Schistosoma mansoni methylthioadenosine phosphorylase 0.0855 0.4775 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0158 0.0735 0.1214
Echinococcus granulosus DNA methyltransferase 2, putative 0.0443 0.2385 0.3941
Entamoeba histolytica hypothetical protein 0.0158 0.0735 0.3081
Schistosoma mansoni hepatoma derived growth factor 0.0091 0.0343 0.0719
Trypanosoma brucei spermidine synthase 0.1074 0.605 1
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0158 0.0735 0.1211
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0002 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0194 0.094 0.1553
Brugia malayi Spermidine synthase 0.1074 0.605 0.6654
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0158 0.0735 0.3081
Schistosoma mansoni uridine phosphorylase 0.0158 0.0735 0.1539
Trichomonas vaginalis CDC6, putative 0.0036 0.0026 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0008 0.0017
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0443 0.2385 0.3939
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0077 0.0266 0.044
Schistosoma mansoni phd finger protein 0.0091 0.0343 0.0719
Leishmania major spermidine synthase 0.1074 0.605 1
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0151 0.069 0.1141
Schistosoma mansoni uridine phosphorylase 0.0158 0.0735 0.1539
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0106 0.0433 0.0715
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0065 0.0195 0.0323
Brugia malayi jmjC domain containing protein 0.004 0.0052 0.0057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0292 0.0611
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0158 0.0735 0.0735
Brugia malayi hypothetical protein 0.0362 0.1918 0.211
Leishmania major arginine N-methyltransferase-like protein 0.0034 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0091 0.0343 0.0719
Loa Loa (eye worm) hypothetical protein 0.0986 0.5537 0.609
Loa Loa (eye worm) hypothetical protein 0.0118 0.0502 0.0553
Echinococcus multilocularis PWWP domain containing protein 2A 0.0091 0.0343 0.0567
Brugia malayi Disco-interacting protein 2 homolog 0.0312 0.1628 0.1791
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0313 0.1633 0.27
Entamoeba histolytica hypothetical protein 0.0065 0.0195 0.0819
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0655 0.3619 0.5982
Schistosoma mansoni methylthioadenosine phosphorylase 0.0158 0.0735 0.1539
Leishmania major methylthioadenosine phosphorylase, putative 0.0855 0.4775 0.7892
Loa Loa (eye worm) uridine phosphorylase 0.0158 0.0735 0.0808
Loa Loa (eye worm) PWWP domain-containing protein 0.0091 0.0343 0.0377
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0237 0.1193 0.1972
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0443 0.2385 0.6281
Trypanosoma cruzi spermidine synthase, putative 0.1074 0.605 1
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0019 0.0021
Onchocerca volvulus 0.0312 0.1628 0.1627
Plasmodium vivax SET domain protein, putative 0.0172 0.0814 0.1342

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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