TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 458.852 | Formula: C21H19ClN4O6
H donors: 1 H acceptors: 4 LogP: 1.22 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(nc1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1c2ccc(c1)N1CCOCC1=O
InChi: 1S/C21H19ClN4O6/c22-12-1-3-14(23-8-12)20(28)24-9-18-16-10-31-17-7-13(25-5-6-30-11-19(25)27)2-4-15(17)26(16)21(29)32-18/h1-4,7-8,16,18H,5-6,9-11H2,(H,24,28)/t16-,18-/m0/s1
InChiKey: ITFNTOJZTHVFBN-WMZOPIPTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor X	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0546	0.7657	0.7451
Loa Loa (eye worm)	hypothetical protein	0.0444	0.6175	0.6124
Trypanosoma brucei	beta tubulin	0.0388	0.5357	0.5355
Echinococcus granulosus	tubulin alpha chain	0.0546	0.7657	0.7656
Echinococcus granulosus	alpha tubulin	0.0546	0.7657	0.7656
Leishmania major	gamma-tubulin	0.0388	0.5357	0.5355
Brugia malayi	MH2 domain containing protein	0.0118	0.144	0.1326
Schistosoma mansoni	alpha tubulin	0.0546	0.7657	0.7656
Loa Loa (eye worm)	tubulin alpha chain	0.0546	0.7657	0.7626
Schistosoma mansoni	acetylcholinesterase	0.0075	0.081	0.0807
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Onchocerca volvulus		0.0075	0.081	0.2442
Loa Loa (eye worm)	BEN-1 protein	0.0707	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0546	0.7657	0.7656
Trypanosoma cruzi	tubulin delta chain	0.0168	0.2167	0.2164
Trichomonas vaginalis	tubulin beta chain, putative	0.0546	0.7657	0.7451
Toxoplasma gondii	beta-1 tubulin, putative	0.0707	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0707	1	1
Echinococcus granulosus	acetylcholinesterase	0.0444	0.6175	0.6173
Echinococcus granulosus	tubulin alpha chain	0.0546	0.7657	0.7656
Loa Loa (eye worm)	tubulin beta-1 chain	0.0707	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0707	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0546	0.7657	0.7656
Echinococcus multilocularis	tubulin alpha chain	0.0546	0.7657	0.7656
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0388	0.5357	0.5355
Brugia malayi	Tubulin alpha chain	0.0546	0.7657	0.7626
Trypanosoma brucei	epsilon tubulin	0.0388	0.5357	0.5355
Trypanosoma cruzi	tubulin gamma chain	0.0388	0.5357	0.5355
Echinococcus granulosus	peroxisome assembly protein 26	0.0546	0.7657	0.7656
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0075	0.081	0.0807
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0075	0.081	0.0807
Loa Loa (eye worm)	acetylcholinesterase 1	0.0444	0.6175	0.6124
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0168	0.2167	0.2164
Trypanosoma brucei	tubulin gamma chain	0.0388	0.5357	0.5355
Schistosoma mansoni	tubulin subunit epsilon	0.0388	0.5357	0.5355
Leishmania major	beta tubulin	0.0707	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0378	0.5209	0.4787
Plasmodium falciparum	tubulin delta chain, putative	0.0168	0.2167	0.2164
Loa Loa (eye worm)	tubulin beta-2A chain	0.0707	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0168	0.2167	0.1477
Echinococcus multilocularis	carboxylesterase 5A	0.0444	0.6175	0.6173
Echinococcus granulosus	geminin	0.0168	0.2161	0.2159
Loa Loa (eye worm)	alpha-tubulin	0.0546	0.7657	0.7626
Onchocerca volvulus		0.0075	0.081	0.2442
Echinococcus multilocularis	tubulin alpha 1C chain	0.0546	0.7657	0.7656
Brugia malayi	Tubulin alpha-2 chain	0.0546	0.7657	0.7626
Trichomonas vaginalis	tubulin beta chain, putative	0.0546	0.7657	0.7451
Schistosoma mansoni	tubulin subunit beta	0.0707	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0546	0.7657	0.7451
Leishmania major	epsilon tubulin, putative	0.0388	0.5357	0.5355
Trichomonas vaginalis	tubulin gamma chain, putative	0.0388	0.5357	0.4947
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.021	0.008
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Giardia lamblia	Epsilon tubulin	0.0168	0.2167	0.2167
Leishmania major	beta tubulin	0.0707	1	1
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.0043	0.0349	0.0345
Trichomonas vaginalis	conserved hypothetical protein	0.0168	0.2167	0.1477
Loa Loa (eye worm)	carboxylesterase	0.0075	0.081	0.0687
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0028	0.0132	0.0128
Trypanosoma brucei	alpha tubulin	0.0546	0.7657	0.7656
Brugia malayi	alpha-tubulin	0.0546	0.7657	0.7626
Leishmania major	beta tubulin	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Loa Loa (eye worm)	carboxylesterase	0.0075	0.081	0.0687
Trichomonas vaginalis	tubulin alpha chain, putative	0.0388	0.5357	0.4947
Loa Loa (eye worm)	hypothetical protein	0.0327	0.4467	0.4394
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0546	0.7657	0.7656
Echinococcus granulosus	tubulin alpha chain	0.0546	0.7657	0.7656
Echinococcus granulosus	beta tubulin	0.0707	1	1
Echinococcus multilocularis	Ankyrin	0.0028	0.0132	0.0128
Echinococcus granulosus	tubulin epsilon chain	0.0388	0.5357	0.5355
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0075	0.081	0.0807
Plasmodium falciparum	alpha tubulin 1	0.0546	0.7657	0.7656
Schistosoma mansoni	tubulin subunit beta	0.0707	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0378	0.5209	0.5146
Loa Loa (eye worm)	beta-tubulin	0.0707	1	1
Loa Loa (eye worm)	hypothetical protein	0.0444	0.6175	0.6124
Echinococcus granulosus	carboxylesterase 5A	0.0444	0.6175	0.6173
Giardia lamblia	Beta tubulin	0.0707	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0707	1	1
Echinococcus granulosus	tubulin subunit TubB	0.0546	0.7657	0.7656
Echinococcus multilocularis	tubulin gamma 1 chain	0.0388	0.5357	0.5355
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Brugia malayi	Tubulin beta chain	0.0168	0.2167	0.2062
Brugia malayi	beta-tubulin, identical	0.0707	1	1
Loa Loa (eye worm)	hypothetical protein	0.0546	0.7657	0.7626
Schistosoma mansoni	ankyrin 23/unc44	0.0028	0.0132	0.0128
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0444	0.6175	0.6173
Echinococcus multilocularis	beta tubulin	0.0707	1	1
Schistosoma mansoni	hypothetical protein	0.0028	0.0132	0.0128
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0707	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0707	1	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.081	0.0687
Schistosoma mansoni	alpha tubulin	0.0546	0.7657	0.7656
Leishmania major	zeta tubulin, putative	0.0168	0.2167	0.2164
Echinococcus multilocularis	tubulin alpha	0.0388	0.5357	0.5355
Echinococcus granulosus	tubulin beta 4A class IVa	0.0707	1	1
Trypanosoma brucei	alpha tubulin	0.0546	0.7657	0.7656
Loa Loa (eye worm)	BEN-1 protein	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0546	0.7657	0.7656
Schistosoma mansoni	tubulin subunit alpha	0.0168	0.2167	0.2164
Leishmania major	beta tubulin	0.0707	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.144	0.1326
Mycobacterium leprae	cell division protein FtsZ	0.0168	0.2167	0.5
Trypanosoma brucei	beta tubulin	0.0707	1	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.081	0.0687
Echinococcus granulosus	tubulin alpha	0.0388	0.5357	0.5355
Entamoeba histolytica	tubulin family protein	0.0707	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0707	1	1
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Trypanosoma brucei	alpha tubulin	0.0546	0.7657	0.7656
Loa Loa (eye worm)	hypothetical protein	0.0075	0.081	0.0687
Trichomonas vaginalis	tubulin beta chain, putative	0.0707	1	1
Schistosoma mansoni	tubulin subunit beta	0.0707	1	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0546	0.7657	0.7656
Leishmania major	delta tubulin, putative	0.0168	0.2167	0.2164
Echinococcus multilocularis	acetylcholinesterase	0.0444	0.6175	0.6173
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0707	1	1
Echinococcus granulosus	death domain containing protein	0.0028	0.0132	0.0128
Trypanosoma brucei	zeta tubulin, putative	0.0168	0.2167	0.2164
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Giardia lamblia	Delta tubulin	0.0168	0.2167	0.2167
Leishmania major	beta tubulin	0.0707	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0546	0.7657	0.7451
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Echinococcus granulosus	neuroligin	0.0075	0.081	0.0807
Giardia lamblia	Alpha-tubulin	0.0546	0.7657	0.7657
Echinococcus granulosus	tubulin alpha 3 chain	0.0546	0.7657	0.7656
Schistosoma mansoni	BC026374 protein (S09 family)	0.0075	0.081	0.0807
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0168	0.2167	0.2164
Plasmodium vivax	tubulin epsilon chain, putative	0.0388	0.5357	0.5355
Leishmania major	beta tubulin	0.0707	1	1
Schistosoma mansoni	tubulin subunit delta	0.0168	0.2167	0.2164
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0438	0.031
Onchocerca volvulus		0.0075	0.081	0.2442
Echinococcus multilocularis	acetylcholinesterase	0.0444	0.6175	0.6173
Brugia malayi	Carboxylesterase family protein	0.0444	0.6175	0.6124
Echinococcus granulosus	beta tubulin	0.0707	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0546	0.7657	0.7656
Echinococcus multilocularis	neuroligin	0.0075	0.081	0.0807
Schistosoma mansoni	netrin receptor unc5	0.0028	0.0132	0.0128
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0075	0.081	0.0807
Echinococcus multilocularis	tubulin epsilon chain	0.0388	0.5357	0.5355
Trichomonas vaginalis	tubulin beta chain, putative	0.0219	0.2909	0.2284
Echinococcus multilocularis	Tubulin beta 2C chain	0.0707	1	1
Echinococcus multilocularis	hypothetical protein	0.0546	0.7657	0.7656
Loa Loa (eye worm)	hypothetical protein	0.0075	0.081	0.0687
Echinococcus granulosus	Ankyrin	0.0028	0.0132	0.0128
Echinococcus granulosus	acetylcholinesterase	0.0444	0.6175	0.6173
Echinococcus granulosus	tubulin alpha chain	0.0546	0.7657	0.7656
Echinococcus multilocularis	Tubulin beta 2C chain	0.0707	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0075	0.081	0.0807
Brugia malayi	Tubulin alpha chain	0.0168	0.2167	0.2062
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.0043	0.0349	0.0345
Trypanosoma brucei	beta tubulin	0.0707	1	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0438	0.031
Loa Loa (eye worm)	hypothetical protein	0.0075	0.081	0.0687
Brugia malayi	Carboxylesterase family protein	0.0444	0.6175	0.6124
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0028	0.0132	0.0128
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.144	0.1326
Trichomonas vaginalis	tubulin, putative	0.0219	0.2909	0.2284
Echinococcus granulosus	tubulin alpha 1C chain	0.0546	0.7657	0.7656
Brugia malayi	Carboxylesterase family protein	0.0075	0.081	0.0687
Schistosoma mansoni	lipoxygenase	0.0115	0.1397	0.1394
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0168	0.2167	1
Loa Loa (eye worm)	carboxylesterase	0.0444	0.6175	0.6124
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0115	0.1397	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0075	0.081	0.0687
Plasmodium falciparum	alpha tubulin 2	0.0546	0.7657	0.7656
Echinococcus granulosus	Tubulin beta 2C chain	0.0707	1	1
Echinococcus multilocularis	geminin	0.0168	0.2161	0.2159
Plasmodium falciparum	tubulin gamma chain	0.0388	0.5357	0.5355
Echinococcus granulosus	netrin receptor unc 5	0.0028	0.0132	0.0128
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0438	0.031
Trichomonas vaginalis	conserved hypothetical protein	0.0168	0.2167	0.1477
Plasmodium vivax	tubulin gamma chain, putative	0.0388	0.5357	0.5355
Loa Loa (eye worm)	tubulin alpha 2	0.0158	0.202	0.1913
Schistosoma mansoni	tubulin subunit beta	0.0707	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0168	0.2167	0.1477
Brugia malayi	Carboxylesterase family protein	0.0075	0.081	0.0687
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Trypanosoma cruzi	zeta tubulin, putative	0.0168	0.2167	0.2164
Trypanosoma cruzi	zeta tubulin, putative	0.0168	0.2167	0.2164
Echinococcus multilocularis	tubulin alpha 3 chain	0.0546	0.7657	0.7656
Onchocerca volvulus		0.0075	0.081	0.2442
Echinococcus multilocularis	tubulin alpha chain	0.0546	0.7657	0.7656
Trypanosoma cruzi	tubulin delta chain	0.0168	0.2167	0.2164
Echinococcus multilocularis	tubulin alpha 1C chain	0.0546	0.7657	0.7656
Echinococcus multilocularis	tubulin alpha chain	0.0546	0.7657	0.7656
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0546	0.7657	0.7656
Loa Loa (eye worm)	hypothetical protein	0.0075	0.081	0.0687
Schistosoma mansoni	hypothetical protein	0.0168	0.2161	0.2159
Echinococcus granulosus	Tubulin beta 2C chain	0.0707	1	1
Trypanosoma brucei	zeta tubulin	0.0168	0.2167	0.2164
Schistosoma mansoni	tubulin subunit gamma	0.0388	0.5357	0.5355
Entamoeba histolytica	tubulin gamma chain	0.0388	0.5357	0.5355
Loa Loa (eye worm)	hypothetical protein	0.0034	0.021	0.008
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0075	0.081	0.0807
Trypanosoma brucei	epsilon tubulin	0.0388	0.5357	0.5355
Onchocerca volvulus		0.0075	0.081	0.2442
Toxoplasma gondii	alpha-tubulin I, putative	0.0546	0.7657	0.7656
Leishmania major	beta tubulin	0.0707	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0707	1	1
Trichomonas vaginalis	tubulin, putative	0.0219	0.2909	0.2284
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0219	0.2909	0.2284
Brugia malayi	Tubulin gamma chain	0.0388	0.5357	0.5295
Plasmodium falciparum	tubulin beta chain	0.0707	1	1
Brugia malayi	Cell division protein ftsZ	0.0168	0.2167	0.2062
Loa Loa (eye worm)	tubulin gamma chain	0.0388	0.5357	0.5295
Giardia lamblia	Gamma tubulin	0.0388	0.5357	0.5357
Echinococcus granulosus	Tubulin beta 2C chain	0.0707	1	1
Echinococcus multilocularis	tubulin subunit beta	0.0707	1	1
Loa Loa (eye worm)	hypothetical protein	0.0378	0.5209	0.5146
Trichomonas vaginalis	tubulin gamma chain, putative	0.0707	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0546	0.7657	0.7626
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0546	0.7657	0.7451
Plasmodium vivax	tubulin alpha chain, putative	0.0546	0.7657	0.7656
Echinococcus multilocularis	tubulin alpha 3 chain	0.0546	0.7657	0.7656
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0028	0.0132	0.0128
Echinococcus granulosus	tubulin alpha 3 chain	0.0546	0.7657	0.7656
Schistosoma mansoni	gliotactin	0.0075	0.081	0.0807
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0378	0.5209	0.5146
Loa Loa (eye worm)	tubulin alpha 2	0.0378	0.5209	0.5146
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0075	0.081	0.0807
Loa Loa (eye worm)	alpha-tubulin	0.0546	0.7657	0.7626
Schistosoma mansoni	tumor necrosis factor receptor related	0.0043	0.0349	0.0345
Giardia lamblia	Alpha-tubulin	0.0546	0.7657	0.7657
Echinococcus multilocularis	beta tubulin	0.0707	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0546	0.7657	0.7656
Schistosoma mansoni	alpha tubulin	0.0546	0.7657	0.7656
Schistosoma mansoni	tubulin subunit beta	0.0168	0.2167	0.2164
Trichomonas vaginalis	tubulin, putative	0.0168	0.2167	0.1477
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.0043	0.0349	0.0345
Echinococcus granulosus	tubulin alpha chain	0.0546	0.7657	0.7656
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0168	0.2167	0.5
Echinococcus granulosus	tubulin subunit beta	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0388	0.5357	0.5355
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0327	0.4467	0.4394
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0546	0.7657	0.7626
Trypanosoma cruzi	epsilon tubulin, putative	0.0388	0.5357	0.5355
Toxoplasma gondii	beta tubulin	0.0707	1	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0075	0.081	0.3728
Trypanosoma brucei	alpha tubulin, putative	0.0219	0.2909	0.2906
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Entamoeba histolytica	tubulin family protein	0.0707	1	1
Trichomonas vaginalis	tubulin, putative	0.0707	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0438	0.031
Schistosoma mansoni	tubulin subunit beta	0.0707	1	1
Trypanosoma brucei	alpha tubulin	0.0546	0.7657	0.7656
Toxoplasma gondii	alpha tubulin TUBA1	0.0546	0.7657	0.7656
Echinococcus granulosus	tubulin beta 1 chain	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0219	0.2909	0.2284
Trichomonas vaginalis	tubulin gamma chain, putative	0.0388	0.5357	0.4947
Loa Loa (eye worm)	tubulin beta chain	0.0168	0.2167	0.2062
Schistosoma mansoni	hypothetical protein	0.0034	0.021	0.0207
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0327	0.4467	0.398
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0546	0.7657	0.7656
Schistosoma mansoni	tubulin subunit alpha	0.0546	0.7657	0.7656
Schistosoma mansoni	tubulin subunit alpha	0.0546	0.7657	0.7656
Trypanosoma brucei	beta tubulin	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0115	0.1397	0.1394
Trichomonas vaginalis	tubulin beta chain, putative	0.0546	0.7657	0.7451
Schistosoma mansoni	tubulin subunit beta	0.0707	1	1
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Leishmania major	beta tubulin	0.0707	1	1
Echinococcus multilocularis	tubulin delta chain	0.0168	0.2167	0.2164
Onchocerca volvulus		0.0219	0.2909	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0388	0.5357	0.5355
Schistosoma mansoni	hypothetical protein	0.0168	0.2161	0.2159
Giardia lamblia	Beta tubulin	0.0707	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0546	0.7657	0.7656
Echinococcus multilocularis	Tubulin beta 2C chain	0.0707	1	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0168	0.2167	1
Toxoplasma gondii	beta-tubulin, putative	0.0707	1	1
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Loa Loa (eye worm)	tubulin beta-4 chain	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Plasmodium vivax	delta tubulin, putative	0.0168	0.2167	0.2164
Echinococcus multilocularis	Tubulin beta 2C chain	0.0707	1	1
Leishmania major	beta tubulin	0.0707	1	1
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0168	0.2167	0.1477
Trichomonas vaginalis	tubulin alpha chain, putative	0.0707	1	1
Brugia malayi	Tubulin beta chain	0.0219	0.2909	0.2814
Echinococcus granulosus	Tubulin alpha 1 chain	0.0546	0.7657	0.7656
Trypanosoma cruzi	alpha tubulin, putative	0.0546	0.7657	0.7656
Brugia malayi	tubulin alpha-2 chain	0.0546	0.7657	0.7626
Treponema pallidum	cell division protein FtsZ	0.0168	0.2167	0.5
Echinococcus multilocularis	tubulin subunit TubB	0.0546	0.7657	0.7656
Echinococcus granulosus	BC026374 protein S09 family	0.0075	0.081	0.0807
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Giardia lamblia	Beta tubulin	0.0707	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0546	0.7657	0.7451
Echinococcus multilocularis	netrin receptor unc 5	0.0028	0.0132	0.0128
Brugia malayi	Carboxylesterase family protein	0.0075	0.081	0.0687
Echinococcus multilocularis	tubulin alpha chain	0.0546	0.7657	0.7656
Trypanosoma brucei	beta tubulin	0.0707	1	1
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.0043	0.0349	0.0345
Brugia malayi	tubulin alpha chain - mouse	0.0546	0.7657	0.7626
Leishmania major	alpha tubulin	0.0546	0.7657	0.7656
Echinococcus granulosus	para nitrobenzyl esterase	0.0075	0.081	0.0807
Echinococcus granulosus	tubulin delta chain	0.0168	0.2167	0.2164
Trichomonas vaginalis	tubulin beta chain, putative	0.0546	0.7657	0.7451
Trichomonas vaginalis	tubulin alpha chain, putative	0.0219	0.2909	0.2284
Leishmania major	beta tubulin	0.0707	1	1
Brugia malayi	hypothetical protein	0.0075	0.081	0.0687
Echinococcus multilocularis	para nitrobenzyl esterase	0.0075	0.081	0.0807
Echinococcus granulosus	Tubulin alpha 1 chain	0.0546	0.7657	0.7656
Trypanosoma brucei	tubulin delta chain	0.0168	0.2167	0.2164
Schistosoma mansoni	lipoxygenase	0.0081	0.0892	0.0889
Echinococcus multilocularis	tubulin alpha chain	0.0546	0.7657	0.7656
Trichomonas vaginalis	tubulin alpha chain, putative	0.0219	0.2909	0.2284
Trypanosoma cruzi	beta tubulin, putative	0.0707	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0707	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0546	0.7657	0.7626
Trypanosoma cruzi	epsilon tubulin, putative	0.0388	0.5357	0.5355
Trypanosoma brucei	epsilon tubulin	0.0388	0.5357	0.5355
Brugia malayi	Carboxylesterase family protein	0.0075	0.081	0.0687

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 710 nM	Inhibition of human factor 10a using N-Z-D-Arg-Gly-Arg-pNA, S-2765 chromogenic substrate	ChEMBL.	25179681

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3330464

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 928884