TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 462.538 | Formula: C27H30N2O5
H donors: 2 H acceptors: 2 LogP: 5.73 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C(C)(C)C)cc(c1OC)OC
InChi: 1S/C27H30N2O5/c1-27(2,3)18-13-11-17(12-14-18)25(30)29-21-10-8-7-9-20(21)26(31)28-19-15-22(32-4)24(34-6)23(16-19)33-5/h7-16H,1-6H3,(H,28,31)(H,29,30)
InChiKey: BOGAMOPRQOBJII-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0034	0.0199	0.1483
Plasmodium falciparum	cysteine proteinase falcipain 3	0.011	0.0704	1
Brugia malayi	cathepsin L-like precursor	0.008	0.0499	0.1262
Loa Loa (eye worm)	hypothetical protein	0.008	0.0499	0.1262
Trichomonas vaginalis	helicase, putative	0.0008	0.0021	0.0153
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0034	0.0199	0.1483
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0052	0.0316	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0052	0.0316	0.5
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0052	0.0316	0.0378
Entamoeba histolytica	cysteine proteinase 1, putative	0.0065	0.0404	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0704	1
Schistosoma mansoni	tyrosinase precursor	0.0094	0.0594	0.0592
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0034	0.0199	0.2816
Echinococcus granulosus	cpg binding protein	0.0035	0.0204	0.0195
Echinococcus multilocularis	cathepsin L	0.0065	0.0404	0.0395
Onchocerca volvulus		0.011	0.0704	1
Trypanosoma cruzi	cysteine peptidase, putative	0.011	0.0704	0.1422
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Schistosoma mansoni	cathepsin F (C01 family)	0.011	0.0704	0.0702
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.059	0.3892	0.3891
Loa Loa (eye worm)	cytochrome P450 family protein	0.0138	0.0887	0.226
Schistosoma mansoni	cathepsin C	0.0034	0.0199	0.0197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.011	0.0704	0.5247
Brugia malayi	cytochrome P450	0.0052	0.0316	0.079
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0021	0.0153
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0021	0.0153
Loa Loa (eye worm)	hypothetical protein	0.011	0.0704	0.1789
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0052	0.0316	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0052	0.0316	0.5
Plasmodium vivax	unspecified product	0.0031	0.0175	0.2477
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0034	0.0199	0.0197
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0303	0.0301
Echinococcus granulosus	cathepsin l cysteine peptidase	0.011	0.0704	0.0695
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0052	0.0316	0.1021
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0039	0.003
Schistosoma mansoni	cpg binding protein	0.0035	0.0204	0.0202
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Loa Loa (eye worm)	acetyltransferase	0.0158	0.1024	0.2614
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0199	0.0489
Brugia malayi	cathepsin F-like cysteine proteinase	0.0034	0.0199	0.0489
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.0404	0.0401
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Brugia malayi	Cathepsin L-like precursor	0.011	0.0704	0.1789
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0254	0.11
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Loa Loa (eye worm)	cysteine protease	0.011	0.0704	0.1789
Onchocerca volvulus		0.011	0.0704	1
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0704	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0065	0.0404	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.011	0.0704	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0199	0.0489
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0206	0.1341	0.3137
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0082	0.0514	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0594	0.1506
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Brugia malayi	Cathepsin L-like precursor	0.011	0.0704	0.1789
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0404	0.0615
Schistosoma mansoni	cpg binding protein	0.0033	0.0192	0.0189
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0199	0.0489
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0158	0.1024	0.1016
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0052	0.0316	0.5
Leishmania major	cathepsin L-like protease	0.011	0.0704	0.3784
Echinococcus multilocularis	cysteine protease	0.011	0.0704	0.0695
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0199	0.1483
Schistosoma mansoni	microtubule-associated protein tau	0.1509	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0199	0.0197
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0052	0.0316	0.5
Echinococcus multilocularis	microtubule associated protein 2	0.1509	1	1
Leishmania major	cysteine peptidase A (CPA)	0.011	0.0704	0.3784
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0065	0.0404	0.4054
Echinococcus multilocularis		0.0052	0.0316	0.0307
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0034	0.0199	0.0489
Schistosoma mansoni	hypothetical protein	0.0052	0.0316	0.0313
Schistosoma mansoni	cathepsin F (C01 family)	0.008	0.0499	0.0497
Loa Loa (eye worm)	CYP4Cod1	0.0082	0.0514	0.1301
Onchocerca volvulus		0.0094	0.0594	0.7854
Loa Loa (eye worm)	cytochrome P450 family protein	0.0082	0.0514	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0199	0.0489
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.0594	0.1506
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.028	0.0272
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0192	0.0471
Trypanosoma cruzi	cysteine protease, putative	0.0065	0.0404	0.0615
Echinococcus multilocularis	dnaJ subfamily B	0.0474	0.312	0.3114
Trypanosoma cruzi	cytochrome P450, putative	0.0082	0.0514	0.0912
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0009	0.0007
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.011	0.0704	0.0695
Brugia malayi	Common central domain of tyrosinase family protein	0.0094	0.0594	0.1506
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0034	0.0199	0.0197
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0303	0.0757
Loa Loa (eye worm)	hypothetical protein	0.008	0.0499	0.1262
Trypanosoma cruzi	cruzipain precursor, putative	0.011	0.0704	0.1422
Echinococcus granulosus	cathepsin L	0.0065	0.0404	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.011	0.0704	0.5247
Leishmania major	cathepsin L-like protease	0.011	0.0704	0.3784
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0031	0.0175	0.0428
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0254	0.11
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.011	0.0704	1
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0052	0.0316	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0067	0.0415	0.1894
Schistosoma mansoni	cathepsin F (C01 family)	0.011	0.0704	0.0702
Brugia malayi	Cathepsin L-like precursor	0.011	0.0704	0.1789
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.059	0.3892	0.3891
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0199	0.0489
Echinococcus granulosus	cathepsin l1	0.011	0.0704	0.0695
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0199	0.0197
Onchocerca volvulus		0.011	0.0704	1
Toxoplasma gondii	cathepsin B	0.0206	0.1341	1
Leishmania major	cathepsin L-like protease	0.011	0.0704	0.3784
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0052	0.0316	0.5
Plasmodium vivax	serine-repeat antigen (SERA)	0.0034	0.0199	0.2816
Brugia malayi	Cathepsin L-like precursor	0.008	0.0499	0.1262
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.059	0.3892	0.3891
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0065	0.0404	0.3009
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0047	0.028	0.2089
Onchocerca volvulus		0.011	0.0704	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0025	0.0017
Echinococcus granulosus	cysteine protease	0.0065	0.0404	0.0395
Onchocerca volvulus	Cathepsin F homolog	0.011	0.0704	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0199	0.0197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0594	0.1506
Onchocerca volvulus	Cathepsin L homolog	0.0034	0.0199	0.0143
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0199	0.0197
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0052	0.0316	0.5
Loa Loa (eye worm)	fibroinase	0.011	0.0704	0.1789
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0052	0.0316	0.0378
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0052	0.0316	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0404	0.0858
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.0199	0.1483
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0025	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0021	0.0153
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.008	0.0499	0.3721
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0052	0.0316	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.011	0.0704	0.1789
Schistosoma mansoni	hypothetical protein	0.0474	0.312	0.3118
Plasmodium vivax	vivapain-1	0.0065	0.0404	0.5728
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0052	0.0316	0.5
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.028	0.3973
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0021	0.0153
Brugia malayi	ShTK domain containing protein	0.0094	0.0594	0.1506
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0052	0.0316	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0199	0.0489
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Echinococcus multilocularis	cathepsin b	0.059	0.3892	0.3887
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0034	0.0199	0.0197
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0025	0.0017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0199	0.1483
Brugia malayi	cathepsin L-like cysteine proteinase	0.0034	0.0199	0.0489
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Mycobacterium leprae	putative cytochrome p450	0.0052	0.0316	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0199	0.1483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0175	0.0428
Loa Loa (eye worm)	cytochrome P450 family protein	0.0082	0.0514	0.1301
Brugia malayi	acetyltransferase, GNAT family protein	0.0158	0.1024	0.2614
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0404	0.0858
Echinococcus granulosus	cathepsin b	0.059	0.3892	0.3887
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0052	0.0316	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.011	0.0704	0.0695
Onchocerca volvulus		0.0094	0.0594	0.7854
Brugia malayi	Cytochrome P450 family protein	0.0082	0.0514	0.1301
Schistosoma mansoni	tyrosinase precursor	0.0094	0.0594	0.0592
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0303	0.0301
Toxoplasma gondii	cathepsin CPL	0.011	0.0704	0.4419
Schistosoma mansoni	zinc finger protein	0.0006	0.0009	0.0007
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0206	0.1341	1
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0052	0.0316	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Schistosoma mansoni	cathepsin B (C01 family)	0.0034	0.0199	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0199	0.1483
Loa Loa (eye worm)	hypothetical protein	0.059	0.3892	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0065	0.0404	0.0395
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0052	0.0316	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0021	0.0153
Echinococcus granulosus	cytochrome P450 2K1	0.0052	0.0316	0.0307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0199	0.1483
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.044	0.0437
Brugia malayi	cathepsin F-like cysteine proteinase	0.0031	0.0175	0.0428
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0052	0.0316	0.5
Loa Loa (eye worm)	ctsf protein	0.011	0.0704	0.1789
Echinococcus multilocularis	cathepsin L	0.0034	0.0199	0.019
Brugia malayi	Cathepsin L-like precursor	0.008	0.0499	0.1262
Brugia malayi	fibroinase precursor	0.0034	0.0199	0.0489
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0199	0.1483
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0034	0.0199	0.0489
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.059	0.3892	1
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0094	0.0594	0.1506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0025	0.0023
Entamoeba histolytica	cysteine proteinase, putative	0.0065	0.0404	0.4054
Plasmodium vivax	unspecified product	0.0065	0.0404	0.5728
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0303	0.0757
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0031	0.0175	0.0428
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0021	0.0153
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.008	0.0499	0.3721
Mycobacterium leprae	Conserved hypothetical protein	0.0052	0.0316	0.5
Onchocerca volvulus		0.011	0.0704	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0034	0.0199	0.0489
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0206	0.1341	1
Entamoeba histolytica	cysteine proteinase, putative	0.0065	0.0404	0.4054
Echinococcus multilocularis	cysteine protease	0.011	0.0704	0.0695
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0038	0.0075
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0034	0.0199	0.0197
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0052	0.0316	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.011	0.0704	0.0695
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0158	0.1024	0.1022
Echinococcus multilocularis	cathepsin L cysteine protease	0.011	0.0704	0.0695
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0199	0.1483
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.0254	0.0486
Leishmania major	cathepsin L-like protease	0.011	0.0704	0.3784
Loa Loa (eye worm)	hypothetical protein	0.003	0.0169	0.0413
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0034	0.0199	0.2816
Schistosoma mansoni	cytochrome P450	0.0052	0.0316	0.0313
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0034	0.0199	0.1483
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0154	0.0994	0.0986
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0052	0.0316	0.5
Giardia lamblia	Cathepsin B precursor	0.0206	0.1341	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0065	0.0404	0.0615
Trypanosoma cruzi	major cysteine proteinase, putative	0.0034	0.0199	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0175	0.0428
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0199	0.0489
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.008	0.0499	0.0871
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Trypanosoma cruzi	cysteine proteinase, putative	0.0065	0.0404	0.0615
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.0594	0.1506
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0034	0.0199	0.2816
Brugia malayi	Cathepsin L-like precursor	0.011	0.0704	0.1789
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0034	0.0199	0.2816
Leishmania major	cathepsin L-like protease	0.011	0.0704	0.3784
Leishmania major	cytochrome p450-like protein	0.0082	0.0514	0.1936
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0065	0.0404	0.4054
Plasmodium vivax	vivapain-2	0.011	0.0704	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0034	0.0199	0.1483
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.011	0.0704	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0034	0.0199	0.1483
Onchocerca volvulus	Cathepsin L homolog	0.011	0.0704	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0034	0.0199	0.0489
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0039	0.003
Trypanosoma cruzi	cysteine peptidase, putative	0.011	0.0704	0.1422
Brugia malayi	cathepsin L precursor	0.0034	0.0199	0.0489
Brugia malayi	Cathepsin L-like cysteine proteinase	0.008	0.0499	0.1262
Echinococcus granulosus	cathepsin l1	0.008	0.0499	0.0491
Onchocerca volvulus		0.008	0.0499	0.6004
Schistosoma mansoni	cathepsin S (C01 family)	0.0034	0.0199	0.0197
Leishmania major	cathepsin L-like protease	0.011	0.0704	0.3784
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0303	0.0301
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.011	0.0704	0.1789
Loa Loa (eye worm)	cathepsin B	0.0206	0.1341	0.3431
Brugia malayi	Papain family cysteine protease containing protein	0.0065	0.0404	0.1016
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0052	0.0316	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0199	0.0489
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Onchocerca volvulus		0.0094	0.0594	0.7854
Brugia malayi	Cathepsin L-like precursor	0.011	0.0704	0.1789
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0039	0.0077
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0052	0.0316	0.0378
Echinococcus granulosus	dnaJ subfamily B	0.0474	0.312	0.3114
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0206	0.1341	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0034	0.0199	0.2816
Brugia malayi	Cathepsin L-like precursor	0.011	0.0704	0.1789
Entamoeba histolytica	cysteine protease, putative	0.011	0.0704	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0034	0.0199	0.1483
Giardia lamblia	Cathepsin B precursor	0.0206	0.1341	1
Echinococcus granulosus	cathepsin L	0.0034	0.0199	0.019
Trypanosoma cruzi	cysteine peptidase, putative	0.011	0.0704	0.1422
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0034	0.0199	0.2816
Brugia malayi	cathepsin B-like cysteine proteinase	0.059	0.3892	1
Onchocerca volvulus		0.0094	0.0594	0.7854
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.028	0.0712
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0886	0.5863	0.586
Trypanosoma brucei	cytochrome P450, putative	0.0082	0.0514	0.1936
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.028	0.0712
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0316	0.079
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0021	0.0153
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0175	0.0428
Giardia lamblia	Cathepsin B precursor	0.0206	0.1341	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0199	0.1483
Plasmodium vivax	unspecified product	0.0034	0.0199	0.2816
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Leishmania major	cathepsin L-like protease	0.011	0.0704	0.3784
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Echinococcus granulosus	cathepsin b	0.059	0.3892	0.3887
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0303	0.0294
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0206	0.1341	0.1339
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0034	0.0199	0.0489
Plasmodium vivax	vivapain-3	0.0065	0.0404	0.5728
Plasmodium vivax	vivapain-2	0.011	0.0704	1
Leishmania major	cathepsin L-like protease	0.011	0.0704	0.3784
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0034	0.0199	0.1483
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0594	0.1506
Trypanosoma cruzi	cytochrome P450, putative	0.0082	0.0514	0.0912
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0021	0.0153
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Echinococcus multilocularis	cpg binding protein	0.0035	0.0204	0.0195
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Entamoeba histolytica	cysteine proteinase, putative	0.0065	0.0404	0.4054
Loa Loa (eye worm)	hypothetical protein	0.008	0.0499	0.1262
Onchocerca volvulus		0.011	0.0704	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0034	0.0199	0.0064
Brugia malayi	Cytochrome P450 family protein	0.0082	0.0514	0.1301
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0404	0.4054
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0034	0.0199	0.2816
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0704	0.3784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Loa Loa (eye worm)	cytochrome P450	0.0052	0.0316	0.079
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0594	0.1506
Loa Loa (eye worm)	tyrosinase 1	0.0094	0.0594	0.1506
Echinococcus multilocularis	cathepsin b	0.059	0.3892	0.3887
Schistosoma mansoni	cathepsin s	0.0031	0.0175	0.0173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0065	0.0404	0.3009
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0034	0.0199	0.2816
Onchocerca volvulus		0.0034	0.0199	0.0143
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.0404	0.0401
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0303	0.0294
Onchocerca volvulus		0.011	0.0704	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0199	0.0489
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0034	0.0199	0.2816
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0199	0.0197
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.0199	0.1483
Onchocerca volvulus	Cathepsin L homolog	0.011	0.0704	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0594	0.1506
Trypanosoma cruzi	cysteine peptidase, putative	0.011	0.0704	0.1422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0704	0.5247
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.0404	0.0401
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0034	0.0199	0.2816
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0009	0.0007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0704	0.5247
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0021	0.0153
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0303	0.0294
Trypanosoma cruzi	cysteine proteinase, putative	0.0065	0.0404	0.0615
Schistosoma mansoni	cpg binding protein	0.0035	0.0204	0.0202
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0034	0.0199	0.0489
Brugia malayi	Papain family cysteine protease containing protein	0.0065	0.0404	0.1016
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0047	0.028	0.2089
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0303	0.0294
Brugia malayi	Cytochrome P450 family protein	0.0138	0.0887	0.226
Plasmodium vivax	serine-repeat antigen (SERA)	0.0034	0.0199	0.2816
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0192	0.0471
Echinococcus granulosus	cathepsin L cysteine proteinase	0.011	0.0704	0.0695
Entamoeba histolytica	cysteine proteinase, putative	0.008	0.0499	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0034	0.0199	0.1483
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0175	0.0428
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.0199	0.1483
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.059	0.3892	0.3891
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0025	0.0017

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3335652

Bibliographic References

No literature references available for this target.

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Detailed information for compound 930717