Detailed information for compound 935419

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.151 | Formula: C16H10BrFO3
  • H donors: 0 H acceptors: 1 LogP: 4.15 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(oc2c(c1=O)cccc2)c1cc(Br)ccc1F
  • InChi: 1S/C16H10BrFO3/c1-20-16-14(19)10-4-2-3-5-13(10)21-15(16)11-8-9(17)6-7-12(11)18/h2-8H,1H3
  • InChiKey: WHTOGUGUIDGIIX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclin dependent kinase 5 0.0129 0.0225 0.0257
Echinococcus granulosus serine:threonine protein kinase N2 0.0089 0.0022 0.0048
Echinococcus granulosus dual specificity mitogen activated protein 0.0358 0.1394 0.3099
Schistosoma mansoni cell adhesion molecule 0.0094 0.0044 0.0117
Brugia malayi bone morphogenetic protein type 1 receptor 0.0218 0.068 0.068
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.013 0.0228 0.0228
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0129 0.0225 0.1304
Echinococcus multilocularis peroxidasin 0.0087 0.001 0.0011
Echinococcus granulosus tyrosine protein kinase shark 0.011 0.0129 0.0286
Brugia malayi hypothetical protein 0.011 0.0125 0.0125
Echinococcus granulosus TGF-beta receptor type-1 0.0192 0.0545 0.1212
Schistosoma mansoni septate junction protein 0.0086 0.0004 0.0011
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0327 0.1234 0.1405
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0387 0.1539 0.3422
Loa Loa (eye worm) SRC-1 0.0234 0.076 0.076
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.021 0.0637 0.1416
Onchocerca volvulus 0.0118 0.0169 0.0165
Giardia lamblia Kinase, CMGC CDK 0.0129 0.0225 0.1055
Trypanosoma cruzi cdc2-related kinase 3 0.0129 0.0225 0.1304
Schistosoma mansoni protein kinase 0.0463 0.193 0.5138
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.031 0.1148 0.6641
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0129 0.0225 0.0225
Entamoeba histolytica protein kinase, putative 0.0327 0.1234 0.714
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0348 0.1341 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0094 0.0044 0.005
Loa Loa (eye worm) hypothetical protein 0.0133 0.0244 0.0244
Echinococcus multilocularis death associated protein kinase 1 0.1806 0.8783 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0146 0.0312 0.083
Schistosoma mansoni protein kinase 0.0463 0.193 0.5138
Schistosoma mansoni serine/threonine protein kinase 0.0603 0.2645 0.7042
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0383 0.152 0.152
Toxoplasma gondii AGC kinase 0.021 0.0637 0.4748
Brugia malayi Protein kinase domain containing protein 0.011 0.0129 0.0129
Trichomonas vaginalis STE family protein kinase 0.0358 0.1394 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0174 0.0453 0.1007
Echinococcus granulosus neuroglian 0.0094 0.0044 0.0098
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0192 0.0545 0.0621
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.013 0.0231 0.0263
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0066 0.047
Echinococcus granulosus roundabout 2 0.0094 0.0044 0.0098
Entamoeba histolytica protein kinase domain containing protein 0.0099 0.0069 0.0399
Loa Loa (eye worm) hypothetical protein 0.0268 0.0932 0.0932
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0333 0.1264 0.1264
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0234 0.076 0.0866
Echinococcus multilocularis mitogen activated protein kinase 14 0.031 0.1148 0.1307
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0099 0.0069 0.0399
Trichomonas vaginalis CK1 family protein kinase 0.0118 0.0169 0.1214
Schistosoma mansoni serine/threonine protein kinase 0.021 0.0637 0.1696
Loa Loa (eye worm) hypothetical protein 0.024 0.0791 0.0791
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.011 0.0125 0.0722
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.013 0.0231 0.0231
Echinococcus multilocularis casein kinase I delta 0.0118 0.0169 0.0193
Loa Loa (eye worm) AUR protein kinase 0.0327 0.1234 0.1234
Echinococcus multilocularis serine:threonine protein kinase N2 0.0089 0.0022 0.0025
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.026 0.0893 0.6424
Toxoplasma gondii AGC kinase 0.0089 0.0022 0.0161
Schistosoma mansoni roundabout 0.0086 0.0004 0.0011
Echinococcus granulosus casein kinase I delta 0.0118 0.0169 0.0376
Echinococcus multilocularis tyrosine protein kinase Srms 0.0198 0.0577 0.0657
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0044 0.0044
Brugia malayi p70 ribosomal S6 kinase beta 0.0089 0.0022 0.0022
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0094 0.0044 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.021 0.0637 0.3686
Echinococcus multilocularis protein tyrosine kinase 0.0821 0.3756 0.4276
Echinococcus granulosus casein kinase I alpha 0.0118 0.0169 0.0376
Schistosoma mansoni protein kinase 0.0118 0.0169 0.045
Echinococcus granulosus Vam6:Vps39 protein 0.011 0.0125 0.0277
Toxoplasma gondii aurora kinase 0.0327 0.1234 0.9198
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.031 0.1148 0.6641
Brugia malayi P38 map kinase family protein 2 0.031 0.1148 0.1148
Echinococcus multilocularis tyrosine kinase 0.011 0.0129 0.0146
Onchocerca volvulus 0.0098 0.0063 0.0059
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0066 0.047
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0004 0.0004
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.013 0.0231 0.0231
Onchocerca volvulus 0.011 0.0129 0.0125
Brugia malayi Fibronectin type III domain containing protein 0.019 0.0533 0.0533
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0383 0.152 0.152
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0225 0.1617
Echinococcus granulosus tyrosine protein kinase Src42A 0.0139 0.0276 0.0613
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0129 0.0225 0.168
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0242 0.0644
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.021 0.0637 0.0725
Echinococcus granulosus tyrosine kinase 0.0198 0.0577 0.1283
Brugia malayi Immunoglobulin I-set domain containing protein 0.019 0.0533 0.0533
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.011 0.0125 0.0722
Loa Loa (eye worm) hypothetical protein 0.011 0.0125 0.0125
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.021 0.0637 0.1416
Echinococcus granulosus cyclin dependent kinase 0.0129 0.0225 0.0501
Echinococcus multilocularis cyclin dependent kinase 1 0.0129 0.0225 0.0257
Echinococcus multilocularis twitchin 0.009 0.0023 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.0603 0.1605
Echinococcus multilocularis tyrosine protein kinase shark 0.011 0.0129 0.0146
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0244 0.081 0.081
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0198 0.0577 0.1283
Brugia malayi SH2 domain containing protein 0.011 0.0129 0.0129
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0234 0.076 0.0866
Schistosoma mansoni protein kinase 0.0167 0.0416 0.1107
Brugia malayi Protein kinase domain containing protein 0.011 0.0129 0.0129
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0044 0.0044
Brugia malayi intracellular kinase 0.0244 0.081 0.081
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0086 0.0004 0.0004
Echinococcus granulosus tyrosine protein kinase Fyn 0.0234 0.076 0.1691
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.021 0.0637 0.3686
Echinococcus multilocularis tyrosine protein kinase HCK 0.015 0.0333 0.0379
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0294 0.1068 0.2374
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0094 0.0044 0.0044
Echinococcus granulosus peroxidasin 0.0087 0.001 0.0021
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.081 0.5814
Brugia malayi hypothetical protein 0.019 0.0533 0.0533
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.013 0.0231 0.0263
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0358 0.1394 0.8065
Trypanosoma brucei rac serine-threonine kinase, putative 0.0098 0.0066 0.0379
Echinococcus granulosus protein kinase C gamma type 0.0089 0.0022 0.0048
Loa Loa (eye worm) TK/ROR protein kinase 0.0116 0.0158 0.0158
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0089 0.0022 0.0025
Entamoeba histolytica protein kinase, putative 0.0244 0.081 0.4689
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0234 0.076 0.0866
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0066 0.047
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0463 0.193 0.2197
Loa Loa (eye worm) hypothetical protein 0.0166 0.0412 0.0412
Giardia lamblia Kinase, AGC AKT 0.0219 0.0682 0.4549
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.013 0.0231 0.1339
Echinococcus multilocularis casein kinase I alpha 0.0118 0.0169 0.0193
Loa Loa (eye worm) hypothetical protein 0.011 0.0129 0.0129
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0198 0.0577 0.0657
Echinococcus granulosus c src tyrosine kinase 0.0146 0.0312 0.0693
Loa Loa (eye worm) hypothetical protein 0.0139 0.0274 0.0274
Schistosoma mansoni protein kinase 0.0327 0.1234 0.3285
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0098 0.0063 0.0063
Echinococcus multilocularis cyclin dependent kinase 7 0.0203 0.0603 0.0686
Echinococcus multilocularis protein KINase family member (kin 25) 0.0201 0.0593 0.0675
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0122 0.019 0.019
Echinococcus granulosus cyclin dependent kinase 1 0.0129 0.0225 0.0501
Loa Loa (eye worm) hypothetical protein 0.011 0.0125 0.0125
Leishmania major protein kinase, putative 0.0099 0.0069 0.0399
Schistosoma mansoni serine/threonine protein kinase 0.0538 0.2312 0.6156
Brugia malayi hypothetical protein 0.0133 0.0244 0.0244
Loa Loa (eye worm) AGC/NDR protein kinase 0.0089 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0086 0.0004 0.0004
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0179 0.0477 0.1061
Loa Loa (eye worm) hypothetical protein 0.0087 0.001 0.001
Loa Loa (eye worm) TK/INSR protein kinase 0.0346 0.1332 0.1332
Echinococcus granulosus defective proboscis extension response 0.0182 0.0493 0.1097
Echinococcus granulosus casein kinase I alpha 0.0118 0.0169 0.0376
Entamoeba histolytica protein kinase, putative 0.015 0.0333 0.1929
Plasmodium falciparum casein kinase 1 0.0118 0.0169 0.1261
Brugia malayi Protein kinase domain containing protein 0.011 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.019 0.0533 0.0533
Echinococcus multilocularis epidermal growth factor receptor 0.019 0.0537 0.0611
Schistosoma mansoni protein kinase C mu 0.0202 0.0596 0.1588
Brugia malayi plexin A 0.009 0.0025 0.0025
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.011 0.0125 0.0722
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0424 0.1728 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.0244 0.0244
Brugia malayi Immunoglobulin I-set domain containing protein 0.0955 0.4437 0.4437
Schistosoma mansoni protein kinase 0.0387 0.1539 0.4097
Giardia lamblia Kinase, CMGC GSK 0.0244 0.081 0.5533
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0348 0.1341 0.7763
Echinococcus granulosus tyrosine protein kinase Fyn 0.0234 0.076 0.1691
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.011 0.0125 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0474 0.1985 0.5284
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0004 0.0004
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0099 0.0069 0.0399
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0358 0.1394 0.1394
Echinococcus multilocularis tyrosine protein kinase Blk 0.0198 0.0577 0.0657
Toxoplasma gondii AGC kinase 0.021 0.0637 0.4748
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0603 0.2645 0.3011
Schistosoma mansoni tyrosine kinase 0.0278 0.0983 0.2617
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0022 0.0058
Plasmodium falciparum calcium-dependent protein kinase 4 0.013 0.0231 0.1724
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.013 0.0231 0.0231
Leishmania major protein kinase A catalytic subunit isoform 1 0.021 0.0637 0.3686
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0086 0.0004 0.0005
Brugia malayi Hr1 repeat family protein 0.0089 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0346 0.1332 0.1332
Echinococcus granulosus tyrosine protein kinase Lyn 0.027 0.0945 0.21
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0348 0.1341 0.7763
Plasmodium falciparum calcium-dependent protein kinase 3 0.013 0.0231 0.1724
Loa Loa (eye worm) AUR protein kinase 0.0327 0.1234 0.1234
Brugia malayi serine/threonine protein kinase 6 0.0327 0.1234 0.1234
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.021 0.0637 0.0637
Echinococcus multilocularis aurora kinase A 0.0327 0.1234 0.1405
Giardia lamblia Kinase, CK1 Casein kinase 0.0118 0.0169 0.0624
Brugia malayi EGF-like domain containing protein 0.0086 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0225 0.06
Loa Loa (eye worm) hypothetical protein 0.0183 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0156 0.0361 0.0361
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0118 0.0169 0.0169
Echinococcus granulosus hypothetical protein 0.0312 0.1157 0.2573
Loa Loa (eye worm) hypothetical protein 0.0139 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0301 0.1103 0.1103
Echinococcus granulosus neuroglian 0.0235 0.0767 0.1705
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0272 0.0953 0.1086
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0561 0.2426 0.2762
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0129 0.0225 0.0225
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0202 0.0596 0.0596
Schistosoma mansoni tyrosine kinase 0.011 0.0129 0.0342
Loa Loa (eye worm) AGC/PKN protein kinase 0.0089 0.0022 0.0022
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0094 0.0044 0.0098
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0348 0.1341 0.7763
Trypanosoma cruzi cdc2-related kinase 1 0.0129 0.0225 0.1304
Loa Loa (eye worm) TK protein kinase 0.0331 0.1256 0.1256
Brugia malayi Protein kinase domain containing protein 0.011 0.0129 0.0129
Onchocerca volvulus Tyrosine kinase homolog 0.0794 0.3618 0.3615
Schistosoma mansoni titin 0.0098 0.0063 0.0169
Onchocerca volvulus 0.0093 0.0039 0.0035
Brugia malayi C1-like domain containing protein 0.0202 0.0596 0.0596
Echinococcus granulosus insulin receptor 0.0346 0.1332 0.2961
Brugia malayi Peroxidasin 0.0087 0.001 0.001
Echinococcus multilocularis protein kinase shaggy 0.0244 0.081 0.0922
Schistosoma mansoni neuroglian 0.0094 0.0044 0.0117
Brugia malayi cell division control protein 2 homolog 0.0129 0.0225 0.0225
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0167 0.0416 0.0416
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0244 0.081 0.1802
Trichomonas vaginalis AGC family protein kinase 0.0327 0.1234 0.8854
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0066 0.047
Entamoeba histolytica protein kinase domain containing protein 0.0244 0.081 0.4689
Trypanosoma cruzi casein kinase, putative 0.0118 0.0169 0.0979
Entamoeba histolytica protein kinase, putative 0.0327 0.1234 0.714
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.014 0.0278 0.0278
Echinococcus granulosus contactin 0.0094 0.0044 0.0098
Echinococcus granulosus plexin a4 0.009 0.0025 0.0055
Echinococcus multilocularis roundabout 2 0.0275 0.0972 0.1106
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Onchocerca volvulus 0.2045 1 1
Schistosoma mansoni tyrosine kinase 0.0128 0.0218 0.0579
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.0603 0.1605
Loa Loa (eye worm) IKK protein kinase 0.2045 1 1
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0219 0.0682 0.0682
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.011 0.0125 0.0332
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0129 0.0225 0.0501
Loa Loa (eye worm) TK/FAK protein kinase 0.083 0.3802 0.3802
Brugia malayi Stress-activated protein kinase jnk-1 0.0538 0.2312 0.2312
Onchocerca volvulus 0.0133 0.0244 0.024
Trichomonas vaginalis STE family protein kinase 0.0358 0.1394 1
Echinococcus granulosus protein kinase c epsilon type 0.0122 0.019 0.0422
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.011 0.0125 0.0277
Echinococcus multilocularis neuroglian 0.0235 0.0767 0.0873
Brugia malayi Furin-like cysteine rich region family protein 0.019 0.0537 0.0537
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0022 0.0058
Echinococcus multilocularis c src tyrosine kinase 0.0146 0.0312 0.0355
Schistosoma mansoni protein kinase 0.0276 0.0975 0.2595
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0044 0.0044
Echinococcus multilocularis serine:threonine protein kinase N2 0.0089 0.0022 0.0025
Echinococcus multilocularis dual specificity protein kinase clk2 0.0348 0.1341 0.1527
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0348 0.1341 0.7763
Echinococcus multilocularis roundabout 2 0.0094 0.0044 0.005
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0272 0.0953 0.212
Schistosoma mansoni serine/threonine protein kinase 0.0272 0.0953 0.2539
Echinococcus granulosus tyrosine protein kinase Src42A 0.0234 0.076 0.1691
Onchocerca volvulus 0.011 0.0129 0.0125
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0383 0.152 0.1517
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0327 0.1234 0.714
Entamoeba histolytica protein kinase domain containing protein 0.0424 0.1728 1
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0358 0.1394 0.1394
Schistosoma mansoni septate junction protein 0.0086 0.0004 0.0011
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0099 0.0069 0.0514
Loa Loa (eye worm) hypothetical protein 0.0094 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0383 0.152 0.152
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0463 0.193 0.4291
Entamoeba histolytica protein kinase, putative 0.0424 0.1728 1
Echinococcus granulosus rho-associated protein kinase 1 0.0474 0.1985 0.4413
Echinococcus granulosus serine:threonine protein kinase mig 15 0.024 0.0791 0.1758
Echinococcus granulosus mitogen activated protein kinase 14 0.031 0.1148 0.2552
Brugia malayi Protein kinase domain containing protein 0.0089 0.0022 0.0022
Echinococcus granulosus casein kinase i 0.0118 0.0169 0.0376
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0234 0.076 0.1691
Echinococcus granulosus casein kinase I alpha 0.0118 0.0169 0.0376
Schistosoma mansoni protein kinase 0.0192 0.0545 0.1451
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.098 0.2609
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0234 0.076 0.0866
Loa Loa (eye worm) TK protein kinase 0.0198 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0214 0.0658 0.0658
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0424 0.1728 1
Schistosoma mansoni tyrosine kinase 0.0128 0.0218 0.0579
Loa Loa (eye worm) hypothetical protein 0.013 0.0231 0.0231
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0348 0.1341 0.1341
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0169 0.0428 0.0428
Schistosoma mansoni rap gtpase-activating protein 0.011 0.0125 0.0332
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0066 0.047
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0327 0.1234 0.714
Loa Loa (eye worm) TK/ABL protein kinase 0.0561 0.2426 0.2426
Echinococcus multilocularis hemicentin 1 0.0086 0.0004 0.0005
Brugia malayi casein kinase I 0.0118 0.0169 0.0169
Echinococcus granulosus tyrosine protein kinase HCK 0.015 0.0333 0.0741
Schistosoma mansoni protein kinase 0.0099 0.0069 0.0184
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0116 0.0158 0.018
Loa Loa (eye worm) AGC/PKA protein kinase 0.021 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.0133 0.0244 0.0244
Entamoeba histolytica SH2-protein kinase domain containing protein 0.011 0.0129 0.0744
Entamoeba histolytica PH domain containing protein kinase, putative 0.0219 0.0681 0.394
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.019 0.0537 0.1193
Brugia malayi Protein kinase domain containing protein 0.1375 0.658 0.658
Echinococcus granulosus activated cdc42 kinase 1 0.0423 0.1724 0.3834
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0174 0.0453 0.0515
Entamoeba histolytica protein kinase, putative 0.0098 0.0066 0.0379
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Loa Loa (eye worm) AGC/PKA protein kinase 0.021 0.0637 0.0637
Schistosoma mansoni tyrosine kinase 0.019 0.0537 0.1429
Giardia lamblia Kinase, NEK 0.026 0.0893 0.6167
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0244 0.081 0.4689
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0225 0.1617
Entamoeba histolytica protein kinase, putative 0.0424 0.1728 1
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Echinococcus multilocularis 0.0167 0.0416 0.0473
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.081 0.5814
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0089 0.0022 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0022 0.0155
Brugia malayi Protein kinase domain containing protein 0.0089 0.0022 0.0022
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0182 0.0493 0.1313
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.013 0.0231 0.1146
Schistosoma mansoni protein kinase 0.0436 0.1792 0.477
Loa Loa (eye worm) CAMK protein kinase 0.0098 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0086 0.0004 0.0004
Brugia malayi hypothetical protein 0.011 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.1227 0.5825 0.5825
Echinococcus multilocularis casein kinase i 0.0118 0.0169 0.0193
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0004 0.0004
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0164 0.0401 0.0457
Echinococcus granulosus tyrosine protein kinase Fps85D 0.011 0.0129 0.0286
Entamoeba histolytica protein kinase , putative 0.0327 0.1234 0.714
Trichomonas vaginalis AGC family protein kinase 0.021 0.0637 0.457
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.021 0.0637 0.4748
Schistosoma mansoni tyrosine kinase 0.0201 0.0593 0.1578
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0109 0.0784
Trichomonas vaginalis STE family protein kinase 0.026 0.0893 0.6408
Schistosoma mansoni serine/threonine protein kinase 0.0315 0.1174 0.3124
Schistosoma mansoni vav2 0.0089 0.0022 0.0058
Echinococcus granulosus twitchin 0.0271 0.0951 0.2114
Schistosoma mansoni serine/threonine protein kinase 0.021 0.0637 0.1696
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.031 0.1148 0.1148
Plasmodium falciparum serine/threonine protein kinase, putative 0.0327 0.1234 0.9198
Loa Loa (eye worm) hypothetical protein 0.011 0.0125 0.0125
Brugia malayi Protein kinase domain containing protein 0.0218 0.068 0.068
Trichomonas vaginalis CMGC family protein kinase 0.0348 0.1341 0.9626
Echinococcus granulosus cyclin dependent kinase 7 0.0203 0.0603 0.134
Entamoeba histolytica protein kinase, putative 0.0098 0.0066 0.0379
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0333 0.1264 0.1264
Brugia malayi Protein kinase domain containing protein 0.0424 0.1728 0.1728
Echinococcus multilocularis Immunoglobulin 0.0182 0.0493 0.0561
Echinococcus multilocularis neuroglian 0.0094 0.0044 0.005
Plasmodium falciparum protein serine/threonine kinase-1 0.0348 0.1341 1
Giardia lamblia Kinase, NEK 0.026 0.0893 0.6167
Loa Loa (eye worm) TK/ALK protein kinase 0.1374 0.6578 0.6578
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0538 0.2312 0.2633
Loa Loa (eye worm) hypothetical protein 0.0086 0.0004 0.0004
Brugia malayi protein kinase C II. 0.0122 0.019 0.019
Echinococcus granulosus tyrosine protein kinase Src64B 0.0234 0.076 0.1691
Loa Loa (eye worm) hypothetical protein 0.0201 0.0593 0.0593
Giardia lamblia Kinase, NEK 0.026 0.0893 0.6167
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.011 0.0129 0.0146
Brugia malayi Protein kinase domain containing protein 0.0129 0.0225 0.0225
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0089 0.0022 0.0022
Plasmodium vivax protein kinase Crk2 0.0129 0.0225 0.1099
Loa Loa (eye worm) hypothetical protein 0.0093 0.0041 0.0041
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0354 0.1372 0.305
Brugia malayi cyclin-dependent kinase 7 homolog 0.022 0.069 0.069
Entamoeba histolytica protein kinase domain containing protein 0.0244 0.081 0.4689
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0118 0.0169 0.0169
Trichomonas vaginalis AGC family protein kinase 0.0327 0.1234 0.8854
Trypanosoma brucei cdc2-related kinase 1 0.0129 0.0225 0.1304
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.026 0.0893 0.6657
Brugia malayi serine/threonine kinase 12 0.0327 0.1234 0.1234
Schistosoma mansoni vesicular amine transporter 0.0182 0.0493 0.1313
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0358 0.1394 0.8065
Trichomonas vaginalis STE family protein kinase 0.0358 0.1394 1
Brugia malayi SRC-1 0.0234 0.076 0.076
Schistosoma mansoni tyrosine kinase 0.019 0.0537 0.1429
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0278 0.0983 0.1119
Echinococcus granulosus cyclin dependent kinase 9 0.0134 0.025 0.0555
Schistosoma mansoni protein kinase 0.0218 0.068 0.181
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.019 0.0506
Echinococcus multilocularis tyrosine protein kinase Abl 0.0318 0.119 0.1355
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0244 0.081 0.0922
Echinococcus multilocularis slit 2 protein 0.0086 0.0004 0.0005
Trypanosoma brucei aurora B kinase 0.0327 0.1234 0.714
Brugia malayi hypothetical protein 0.0603 0.2645 0.2645
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0169 0.045
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.013 0.0231 0.0514
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0234 0.076 0.0866
Plasmodium falciparum protein kinase, putative 0.0099 0.0069 0.0514
Echinococcus multilocularis cyclin dependent kinase 9 0.0134 0.025 0.0284
Loa Loa (eye worm) hypothetical protein 0.0388 0.1544 0.1544
Onchocerca volvulus 0.0244 0.081 0.0807
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0327 0.1234 0.2744
Entamoeba histolytica protein kinase domain containing protein 0.0134 0.025 0.1445
Entamoeba histolytica casein kinase, putative 0.0118 0.0169 0.0979
Brugia malayi serine/threonine-protein kinase 6 0.0327 0.1234 0.1234
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0234 0.076 0.1691
Schistosoma mansoni tyrosine kinase 0.0514 0.2187 0.5822
Trypanosoma cruzi casein kinase, putative 0.0118 0.0169 0.0979
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.021 0.0637 0.3686
Leishmania major protein kinase, putative 0.013 0.0231 0.1339
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.031 0.1148 0.6641
Echinococcus multilocularis dual specificity 0.0424 0.1728 0.1967
Plasmodium falciparum calcium-dependent protein kinase 5 0.013 0.0231 0.1724
Schistosoma mansoni nephrin 0.0094 0.0044 0.0117
Loa Loa (eye worm) hypothetical protein 0.0388 0.1544 0.1544
Giardia lamblia Kinase, AGC PKA 0.021 0.0637 0.4206
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0063 0.0169
Trypanosoma cruzi cdc2-related kinase 1 0.0129 0.0225 0.1304
Leishmania major protein kinase A catalytic subunit isoform 2 0.021 0.0637 0.3686
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0146 0.0309 0.0352
Plasmodium vivax glycogen synthase kinase 3, putative 0.0244 0.081 0.5763
Schistosoma mansoni tyrosine kinase 0.0346 0.1332 0.3546
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.021 0.0637 0.3686
Entamoeba histolytica protein kinase, putative 0.0089 0.0022 0.0125
Entamoeba histolytica protein kinase, putative 0.0089 0.0022 0.0125
Trypanosoma cruzi casein kinase, putative 0.0118 0.0169 0.0979
Brugia malayi Protein kinase domain containing protein 0.1399 0.6703 0.6703
Onchocerca volvulus 0.011 0.0129 0.0125
Schistosoma mansoni tyrosine kinase 0.0513 0.2183 0.5811
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0094 0.0044 0.0117
Schistosoma mansoni tyrosine kinase 0.0234 0.076 0.2024
Plasmodium vivax serine/threonine kinase-1, putative 0.0348 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.1157 0.1157
Onchocerca volvulus 0.0678 0.3025 0.3022
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.021 0.0637 0.0725
Plasmodium falciparum calcium-dependent protein kinase 1 0.013 0.0231 0.1724
Brugia malayi Protein kinase domain containing protein 0.083 0.3802 0.3802
Echinococcus granulosus dual specificity protein kinase clk2 0.0348 0.1341 0.2983
Brugia malayi Tyrosine-protein kinase abl-1 0.0278 0.0985 0.0985
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0603 0.2645 0.2645
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0287 0.1031 0.1031
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.013 0.0231 0.1146
Echinococcus multilocularis calcium dependent protein kinase 0.0094 0.0047 0.0054
Brugia malayi Protein kinase domain containing protein 0.0387 0.1539 0.1539
Schistosoma mansoni kinase 0.0134 0.025 0.0665
Echinococcus granulosus NDR protein kinase 0.0089 0.0022 0.0048
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0546 0.2352 0.2678
Schistosoma mansoni titin 0.0086 0.0004 0.0011
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0424 0.1728 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0218 0.068 0.068
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0429 0.1756 0.1756
Entamoeba histolytica protein kinase, putative 0.013 0.0231 0.1339
Brugia malayi protein unc-22 0.0098 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.0164 0.0401 0.0401
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0089 0.0022 0.0022
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.011 0.0125 0.0332
Schistosoma mansoni cell adhesion molecule 0.0086 0.0004 0.0011
Giardia lamblia Kinase, CMGC CLK 0.0348 0.1341 0.96
Brugia malayi Protein kinase domain containing protein 0.0098 0.0066 0.0066
Echinococcus granulosus roundabout 2 0.0275 0.0972 0.216
Echinococcus multilocularis mitogen activated protein kinase 14 0.031 0.1148 0.1307
Schistosoma mansoni protein kinase 0.0436 0.1792 0.477
Plasmodium falciparum glycogen synthase kinase 3 0.0244 0.081 0.604
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0182 0.0493 0.1313
Brugia malayi protein-tyrosine kinase 0.0198 0.0577 0.0577
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0225 0.1617
Schistosoma mansoni tyrosine kinase 0.019 0.0537 0.1429
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0099 0.0069 0.0399
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0225 0.06
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.013 0.0231 0.0514
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0294 0.1068 0.1068
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0348 0.1341 0.7763
Echinococcus granulosus aurora kinase A 0.0327 0.1234 0.2744
Brugia malayi Protein kinase domain containing protein 0.0169 0.0428 0.0428
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0089 0.0022 0.0048
Entamoeba histolytica protein kinase, putative 0.013 0.0231 0.1339
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.1068 0.2843
Schistosoma mansoni serine/threonine kinase 0.0089 0.0022 0.0058
Echinococcus granulosus tyrosine protein kinase ABL1 0.0561 0.2426 0.5395
Brugia malayi Protein kinase domain containing protein 0.0348 0.1341 0.1341
Echinococcus granulosus c-Jun N-terminal kinases 0.0538 0.2312 0.5142
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0179 0.0477 0.0543
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0164 0.0401 0.0891
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0244 0.081 0.2157
Echinococcus multilocularis raf serine:threonine protein kinase 0.0096 0.0053 0.006
Plasmodium vivax casein kinase 1, putative 0.0118 0.0169 0.065
Echinococcus multilocularis mitogen activated protein kinase 11 0.031 0.1148 0.1307
Trypanosoma brucei protein kinase, putative 0.0099 0.0069 0.0399
Echinococcus granulosus cyclin dependent kinase 5 0.0129 0.0225 0.0501
Echinococcus granulosus calcium dependent protein kinase 0.0094 0.0047 0.0105
Entamoeba histolytica cell division protein kinase 2, putative 0.0146 0.0313 0.1812
Entamoeba histolytica hypothetical protein 0.0424 0.1728 1
Loa Loa (eye worm) TK protein kinase 0.015 0.0333 0.0333
Onchocerca volvulus 0.0301 0.1103 0.11
Loa Loa (eye worm) hypothetical protein 0.0182 0.0493 0.0493
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.021 0.0637 0.3686
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0358 0.1394 0.8065
Schistosoma mansoni serine/threonine protein kinase 0.021 0.0637 0.1696
Schistosoma mansoni tyrosine kinase 0.0346 0.1332 0.3546
Schistosoma mansoni tyrosine kinase 0.0097 0.0058 0.0156
Schistosoma mansoni protein kinase 0.0463 0.193 0.5138
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.021 0.0637 0.3686
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0118 0.0169 0.0979
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0234 0.076 0.0866
Brugia malayi Cam kinase protein 1 0.013 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0301 0.1103 0.1103
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0066 0.047
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1399 0.6703 0.6703
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0004 0.0004
Echinococcus granulosus epidermal growth factor receptor 0.019 0.0537 0.1193
Echinococcus multilocularis lachesin 0.0086 0.0004 0.0005
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0122 0.019 0.0216
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0203 0.0603 0.0603
Echinococcus multilocularis titin 0.0098 0.0063 0.0072
Onchocerca volvulus 0.0166 0.0412 0.0408
Loa Loa (eye worm) hypothetical protein 0.036 0.1405 0.1405
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.021 0.0637 0.0725
Echinococcus granulosus casein kinase I delta 0.0118 0.0169 0.0376
Echinococcus granulosus protein kinase shaggy 0.0244 0.081 0.1802
Echinococcus granulosus Protein kinase C brain isozyme 0.0122 0.019 0.0422
Brugia malayi Prion-like- 0.0086 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0182 0.0493 0.0493
Echinococcus multilocularis Immunoglobulin 0.0182 0.0493 0.0561
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0094 0.0044 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0022 0.0058
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0327 0.1234 0.9142
Loa Loa (eye worm) hypothetical protein 0.0391 0.1559 0.1559
Loa Loa (eye worm) hypothetical protein 0.0086 0.0004 0.0004
Trypanosoma cruzi casein kinase, putative 0.0118 0.0169 0.0979
Echinococcus multilocularis cyclin dependent kinase 9 0.0151 0.0337 0.0384
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0287 0.1031 0.2293
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0164 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.019 0.0533 0.0533
Brugia malayi Serine/threonine-protein kinase SULU 0.0603 0.2645 0.2645
Echinococcus multilocularis serine threonine protein kinase 0.0089 0.0022 0.0025
Brugia malayi Temporarily assigned gene name protein 59 0.011 0.0125 0.0125
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0436 0.1792 0.3984
Loa Loa (eye worm) hypothetical protein 0.019 0.0533 0.0533
Echinococcus granulosus protein kinase 0.0167 0.0416 0.0924
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0169 0.0428 0.0428
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.021 0.0637 0.0725
Schistosoma mansoni cell adhesion molecule 0.0094 0.0044 0.0117
Trichomonas vaginalis AGC family protein kinase 0.0327 0.1234 0.8854
Echinococcus granulosus TGF beta receptor type 1 0.0192 0.0545 0.1212
Schistosoma mansoni nephrin 0.0243 0.0807 0.2148
Brugia malayi protein C17H12.11 0.0133 0.0244 0.0244
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0278 0.0278
Brugia malayi cyclin-dependent kinase 9 0.0134 0.025 0.025
Echinococcus multilocularis cyclin dependent kinase 1 0.0129 0.0225 0.0257
Brugia malayi casein kinase 1, delta 0.0118 0.0169 0.0169
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0477 0.1271
Brugia malayi Tyrosine-protein kinase abl-1 0.0318 0.119 0.119
Echinococcus granulosus lachesin 0.0086 0.0004 0.0009
Echinococcus granulosus tyrosine protein kinase Blk 0.0198 0.0577 0.1283
Echinococcus multilocularis activin receptor type 0.0895 0.413 0.4703
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0004 0.0004
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.04 0.1609 0.1609
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0354 0.1372 0.1562
Echinococcus multilocularis tyrosine protein kinase otk 0.0086 0.0004 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0234 0.076 0.1691
Echinococcus granulosus tyrosine protein kinase otk 0.0086 0.0004 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0348 0.1341 0.3571
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0086 0.0004 0.0004
Echinococcus granulosus titin 0.0098 0.0063 0.0141
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.031 0.1148 0.6641
Echinococcus multilocularis cyclin dependent kinase 0.0129 0.0225 0.0257
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.04 0.1608 0.1831
Schistosoma mansoni serine/threonine protein kinase 0.0429 0.1756 0.4675
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0139 0.0276 0.0314
Toxoplasma gondii casein kinase I 0.0118 0.0169 0.1261
Trypanosoma cruzi casein kinase, putative 0.0118 0.0169 0.0979
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0477 0.1271
Leishmania major protein kinase A catalytic subunit 0.021 0.0637 0.3686
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0294 0.1068 0.1068
Schistosoma mansoni tyrosine kinase 0.0146 0.0312 0.083
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.013 0.0231 0.1724
Trypanosoma cruzi aurora B kinase, putative 0.0327 0.1234 0.714
Echinococcus granulosus mitogen activated protein kinase 11 0.031 0.1148 0.2552
Echinococcus granulosus tyrosine protein kinase Srms 0.011 0.0129 0.0286
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.013 0.0231 0.0514
Trypanosoma brucei cdc2-related kinase 3 0.0129 0.0225 0.1304
Echinococcus granulosus slit 2 protein 0.0086 0.0004 0.001
Leishmania major protein kinase, putative 0.0348 0.1341 0.7763
Brugia malayi Immunoglobulin I-set domain containing protein 0.0331 0.1256 0.1256
Schistosoma mansoni tyrosine kinase 0.0234 0.076 0.2024
Schistosoma mansoni tyrosine kinase 0.0148 0.0323 0.086
Brugia malayi Protein kinase domain containing protein 0.011 0.0129 0.0129
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0234 0.076 0.0866
Echinococcus granulosus Immunoglobulin 0.0182 0.0493 0.1097
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0129 0.0225 0.0225
Entamoeba histolytica protein kinase domain containing protein 0.0327 0.1234 0.714
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.013 0.0231 0.1724
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0094 0.0044 0.005
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0315 0.1174 0.1174
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Loa Loa (eye worm) gastrulation defective protein 1 0.0393 0.1572 0.1572
Onchocerca volvulus 0.011 0.0129 0.0125
Echinococcus granulosus activated cdc42 kinase 1 0.0423 0.1724 0.3834
Loa Loa (eye worm) AGC/AKT protein kinase 0.0098 0.0066 0.0066
Onchocerca volvulus 0.0174 0.0456 0.0452
Echinococcus granulosus tyrosine kinase 0.011 0.0129 0.0286
Plasmodium falciparum protein kinase 5 0.0129 0.0225 0.168
Brugia malayi SH2 domain containing protein 0.011 0.0129 0.0129
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0434 0.1782 0.1782
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0023 0.0062
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.013 0.0231 0.1724
Echinococcus granulosus dual specificity 0.0424 0.1728 0.3842
Loa Loa (eye worm) hypothetical protein 0.0301 0.1103 0.1103
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0169 0.0428 0.0428
Onchocerca volvulus 0.0474 0.1985 0.1981
Echinococcus multilocularis dual specificity mitogen activated protein 0.0358 0.1394 0.1587
Schistosoma mansoni growth factor receptor-bound protein 0.0087 0.0011 0.0028
Echinococcus multilocularis 0.0312 0.1157 0.1318
Entamoeba histolytica cell division protein kinase 2, putative 0.0129 0.0225 0.1304
Leishmania major casein kinase, putative 0.0118 0.0169 0.0979
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0227 0.0726 0.4199
Plasmodium falciparum calcium-dependent protein kinase 2 0.013 0.0231 0.1724
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Loa Loa (eye worm) TK/EGFR protein kinase 0.019 0.0537 0.0537
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0202 0.0596 0.0596
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0129 0.0225 0.1304
Leishmania major protein kinase, putative 0.0327 0.1234 0.714
Echinococcus multilocularis serine:threonine protein kinase 38 0.0089 0.0022 0.0025
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0287 0.1031 0.1031
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0234 0.076 0.0866
Brugia malayi Protein kinase domain containing protein 0.0423 0.1724 0.1724
Echinococcus multilocularis plexin a4 0.009 0.0025 0.0028
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0089 0.0022 0.0048
Echinococcus multilocularis NCK adaptor protein 0.0087 0.0011 0.0012
Echinococcus multilocularis casein kinase I alpha 0.0118 0.0169 0.0193
Echinococcus multilocularis rho associated protein kinase 0.0474 0.1985 0.226
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Brugia malayi serine/threonine-protein kinase PAK 7 0.0434 0.1782 0.1782
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0294 0.1068 0.1216
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0004 0.0004
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0387 0.1539 0.1752
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0231 0.0616
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0315 0.1174 0.1174
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0546 0.2352 0.5231
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.021 0.0637 0.4381
Entamoeba histolytica casein kinase 1, putative 0.0118 0.0169 0.0979
Echinococcus granulosus roundabout 2 0.0094 0.0044 0.0098
Giardia lamblia Kinase, CMGC GSK 0.0244 0.081 0.5533
Schistosoma mansoni serine/threonine protein kinase 0.0383 0.152 0.4048
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0244 0.081 0.4689
Echinococcus multilocularis TGF beta receptor type 1 0.0192 0.0545 0.0621
Trichomonas vaginalis AGC family protein kinase 0.026 0.0893 0.6408
Echinococcus multilocularis activated cdc42 kinase 1 0.0423 0.1724 0.1963
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0146 0.0312 0.083
Schistosoma mansoni serine/threonine protein kinase 0.0348 0.1341 0.3571
Entamoeba histolytica PH domain containing protein kinase, putative 0.0219 0.0681 0.394
Onchocerca volvulus 0.011 0.0129 0.0125
Echinococcus granulosus epidermal growth factor receptor 0.019 0.0537 0.1193
Brugia malayi probable protein kinase 0.0276 0.0975 0.0975
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0053 0.0141
Onchocerca volvulus 0.011 0.0129 0.0125
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0116 0.0158 0.0352
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0278 0.0983 0.2186
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0383 0.152 0.1731
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0201 0.0593 0.1318
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.021 0.0637 0.1416
Onchocerca volvulus 0.011 0.0125 0.0121
Echinococcus granulosus cyclin dependent kinase 19 0.0429 0.1756 0.3904
Trichomonas vaginalis CAMK family protein kinase 0.013 0.0231 0.166
Giardia lamblia Kinase, STE STE20 0.0358 0.1394 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.013 0.0231 0.1146
Plasmodium vivax calcium-dependent protein kinase, putative 0.013 0.0231 0.1146
Loa Loa (eye worm) hypothetical protein 0.0086 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0334 0.1272 0.1272
Echinococcus granulosus raf serine:threonine protein kinase 0.0096 0.0053 0.0118
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.021 0.0637 0.4748
Schistosoma mansoni tyrosine kinase 0.0821 0.3756 1
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0287 0.1031 0.1031
Loa Loa (eye worm) hypothetical protein 0.0268 0.0932 0.0932
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0146 0.0309 0.0687
Echinococcus multilocularis mitogen activated protein kinase 11 0.031 0.1148 0.1307
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.04 0.1608 0.3576
Echinococcus multilocularis transfer RNA-Thr 0.0423 0.1724 0.1963
Echinococcus granulosus growth factor receptor bound protein 2 0.0087 0.0011 0.0023
Loa Loa (eye worm) AUR protein kinase 0.0327 0.1234 0.1234
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0118 0.0169 0.0169
Echinococcus granulosus titin 0.0098 0.0063 0.0141
Trichomonas vaginalis CK1 family protein kinase 0.0118 0.0169 0.1214
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.021 0.0637 0.3686
Echinococcus multilocularis insulin receptor 0.0346 0.1332 0.1516
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0383 0.152 0.152
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0234 0.076 0.0866
Echinococcus multilocularis casein kinase I delta 0.0118 0.0169 0.0193
Brugia malayi Protein kinase domain containing protein 0.0429 0.1756 0.1756
Trichomonas vaginalis CK1 family protein kinase 0.0118 0.0169 0.1214
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0955 0.4437 0.4437
Trypanosoma cruzi cdc2-related kinase 3 0.0129 0.0225 0.1304
Echinococcus multilocularis epidermal growth factor receptor 0.019 0.0537 0.0611
Trypanosoma brucei casein kinase I, isoform 2 0.0118 0.0169 0.0979
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0244 0.081 0.081
Plasmodium falciparum NIMA related kinase 1 0.026 0.0893 0.6657
Echinococcus granulosus hemicentin 1 0.0086 0.0004 0.0009
Trypanosoma brucei protein kinase, putative 0.0244 0.081 0.4689
Schistosoma mansoni vam6/vps39 related 0.011 0.0125 0.0332
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0603 0.2645 0.5881
Echinococcus multilocularis protein kinase c epsilon type 0.0122 0.019 0.0216
Echinococcus multilocularis cyclin dependent kinase 19 0.0429 0.1756 0.1999
Trichomonas vaginalis AGC family protein kinase 0.0327 0.1234 0.8854
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0066 0.047
Schistosoma mansoni atypical protein kinase C 0.0122 0.019 0.0506
Giardia lamblia Aurora kinase 0.0327 0.1234 0.8777
Schistosoma mansoni hypothetical protein 0.011 0.0125 0.0332
Echinococcus multilocularis casein kinase I alpha 0.0118 0.0169 0.0193
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0086 0.0004 0.0011
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0538 0.2312 0.2312
Schistosoma mansoni cell adhesion molecule 0.0222 0.0698 0.1859
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0134 0.025 0.025
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0966 0.4497 1
Echinococcus granulosus protein kinase c iota type 0.0122 0.019 0.0422
Echinococcus granulosus cyclin dependent kinase 9 0.0151 0.0337 0.075
Schistosoma mansoni serine/threonine protein kinase 0.04 0.1609 0.4283
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0383 0.152 0.338
Schistosoma mansoni serine/threonine protein kinase 0.0424 0.1728 0.4601
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0327 0.1234 0.714
Loa Loa (eye worm) hypothetical protein 0.0235 0.0763 0.0763
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.025 0.0665
Onchocerca volvulus 0.0438 0.18 0.1797
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0287 0.1031 0.1174
Giardia lamblia Kinase, CMGC CDK 0.0129 0.0225 0.1055
Schistosoma mansoni protein kinase 0.0358 0.1394 0.371
Echinococcus multilocularis protein kinase c iota type 0.0122 0.019 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.1234 0.3285
Echinococcus granulosus protein tyrosine kinase 0.0821 0.3756 0.8352
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.019 0.0506
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0182 0.0493 0.0561
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0424 0.1728 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0348 0.1341 0.7763
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0278 0.0983 0.1119
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0424 0.1728 0.1728
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0272 0.0953 0.0953
Loa Loa (eye worm) hypothetical protein 0.021 0.0637 0.0637
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0066 0.047
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0214 0.0658 0.1463
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0244 0.081 0.604
Echinococcus multilocularis roundabout 2 0.0094 0.0044 0.005
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0089 0.0022 0.0025
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.013 0.0231 0.0263
Loa Loa (eye worm) hypothetical protein 0.0174 0.0456 0.0456
Loa Loa (eye worm) plexin A 0.009 0.0025 0.0025
Leishmania major protein kinase, putative 0.0348 0.1341 0.7763
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0022 0.0155
Schistosoma mansoni tyrosine kinase 0.0128 0.0218 0.0579
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0086 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0423 0.1724 0.1724
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.019 0.0506
Echinococcus multilocularis hemicentin 1 0.0086 0.0004 0.0005
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0436 0.1792 0.204
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0387 0.1539 0.1539
Brugia malayi Immunoglobulin I-set domain containing protein 0.0098 0.0063 0.0063
Echinococcus granulosus activin receptor type 0.0895 0.413 0.9184
Echinococcus granulosus fibroblast growth factor receptor 4 0.0278 0.0983 0.2186
Brugia malayi Protein kinase domain containing protein 0.04 0.1609 0.1609

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Agonist activity at human PTH receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human D1 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at mouse MC3 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human D5 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human NPY5 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human Glu receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human A3 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human MCH1 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human A1 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human 5HT2C receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human NMU1 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human orexin 2 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human M1 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human MC4 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at mouse MC4 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at mouse MC1 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human C5a receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human MC3 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human MC1 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at mouse MC5 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human A2a receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at human MC2 receptor at 100 uM to 5 mM ChEMBL. 25262941
Activity (binding) Agonist activity at mouse MC2 receptor at 100 uM to 5 mM ChEMBL. 25262941
EC50 (binding) Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay ChEMBL. 25262941

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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