TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 445.51 | Formula: C21H24FN5O3S
H donors: 1 H acceptors: 5 LogP: 2.93 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCc1cc(c(cc1O[C@H]1CCC[C@@H]1c1ccnn1C)F)S(=O)(=O)Nc1ccncn1
InChi: 1S/C21H24FN5O3S/c1-3-14-11-20(31(28,29)26-21-8-9-23-13-24-21)16(22)12-19(14)30-18-6-4-5-15(18)17-7-10-25-27(17)2/h7-13,15,18H,3-6H2,1-2H3,(H,23,24,26)/t15-,18+/m1/s1
InChiKey: PTIFTJFHUAIOAS-QAPCUYQASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0033	0.0163	0.5
Echinococcus multilocularis	muscleblind protein 1	0.0533	0.7041	0.9698
Brugia malayi	beta-lactamase family protein	0.0117	0.132	0.1818
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0231	0.0318
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0034	0.0182	0.0251
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.0628	0.0865
Trichomonas vaginalis	phosphofructokinase, putative	0.0122	0.1389	0.1913
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0033	0.0163	0.0225
Trichomonas vaginalis	D-aminoacylase, putative	0.0117	0.132	0.1818
Mycobacterium tuberculosis	Probable aminopeptidase PepC	0.0549	0.726	0.726
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0023	0.0026	0.0036
Onchocerca volvulus		0.0034	0.0182	0.1205
Echinococcus granulosus	beta LACTamase domain containing family member	0.0117	0.132	0.1818
Loa Loa (eye worm)	beta-lactamase	0.0117	0.132	0.1818
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0549	0.726	1
Plasmodium falciparum	basic transcription factor 3b, putative	0.0024	0.0035	0.0048
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0117	0.132	0.132
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0151	0.1785	0.2458
Echinococcus multilocularis	muscleblind protein	0.0533	0.7041	0.9698
Loa Loa (eye worm)	transcription factor SMAD2	0.0081	0.0821	0.1131
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0257	0.3248	0.4474
Brugia malayi	methionyl-tRNA synthetase	0.0037	0.0221	0.0305
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0257	0.3248	0.4474
Leishmania major	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	0.0549	0.726	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.0363	0.2747
Loa Loa (eye worm)	hypothetical protein	0.0117	0.132	0.1818
Entamoeba histolytica	transcription factor BTF3, putative	0.0024	0.0035	0.0048
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0163	0.0225
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0035	0.0048
Plasmodium vivax	M18 aspartyl aminopeptidase, putative	0.0549	0.726	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0168	0.2019	0.2019
Entamoeba histolytica	aspartyl aminopeptidase, putative	0.0549	0.726	1
Echinococcus granulosus	transcription factor btf3	0.0024	0.0035	0.0048
Mycobacterium leprae	conserved hypothetical protein	0.0117	0.132	0.1561
Entamoeba histolytica	phosphofructokinase, putative	0.0122	0.1389	0.1913
Mycobacterium tuberculosis	Probable esterase LipL	0.0117	0.132	0.132
Brugia malayi	MH2 domain containing protein	0.0081	0.0821	0.1131
Schistosoma mansoni	survival motor neuron protein	0.0034	0.0182	0.0251
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0037	0.0221	1
Mycobacterium tuberculosis	Probable hydrolase	0.0117	0.132	0.132
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0549	0.726	1
Loa Loa (eye worm)	hypothetical protein	0.0168	0.2026	0.2791
Trypanosoma cruzi	metallo-peptidase, Clan MH, Family M20	0.0549	0.726	1
Echinococcus multilocularis	zinc finger protein	0.0024	0.0045	0.0062
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.0363	0.2747
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.0363	0.0499
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.0163	0.0225
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0151	0.1785	0.2458
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0427	0.0589
Echinococcus multilocularis	transcription factor btf3	0.0024	0.0035	0.0048
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0037	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0736	0.1014
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0117	0.132	0.132
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0117	0.132	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0117	0.132	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0533	0.7041	0.9698
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0319	0.4094	0.564
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0117	0.132	0.6538
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.0277	0.0381
Brugia malayi	phosphofructokinase	0.0122	0.1389	0.1913
Brugia malayi	hypothetical protein	0.0168	0.2026	0.2791
Toxoplasma gondii	hypothetical protein	0.0051	0.0417	0.3156
Loa Loa (eye worm)	hypothetical protein	0.0117	0.132	0.1818
Onchocerca volvulus		0.0117	0.132	1
Loa Loa (eye worm)	acetyltransferase	0.0155	0.1848	0.2546
Echinococcus multilocularis	aspartyl aminopeptidase	0.0549	0.726	1
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0549	0.726	1
Schistosoma mansoni	methionine-tRNA synthetase	0.0037	0.0221	0.0305
Trichomonas vaginalis	esterase, putative	0.0117	0.132	0.1818
Toxoplasma gondii	phosphofructokinase PFKII	0.0033	0.0163	0.1236
Echinococcus multilocularis	geminin	0.0179	0.217	0.2988
Echinococcus granulosus	microtubule associated protein 2	0.0467	0.6135	0.845
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0427	0.0589
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0045	0.0326	0.0449
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0033	0.0163	0.1175
Trichomonas vaginalis	conserved hypothetical protein	0.0257	0.3248	0.4474
Trypanosoma cruzi	hypothetical protein, conserved	0.0117	0.132	0.1818
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0427	0.0589
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0549	0.726	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.132	0.1818
Loa Loa (eye worm)	MH2 domain-containing protein	0.0081	0.0821	0.1131
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0033	0.0163	0.0225
Trichomonas vaginalis	conserved hypothetical protein	0.0257	0.3248	0.4474
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0037	0.0051
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0427	0.0589
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0037	0.0051
Giardia lamblia	Methionyl-tRNA synthetase	0.0037	0.0221	0.7998
Mycobacterium tuberculosis	Probable lipase LipD	0.0117	0.132	0.132
Schistosoma mansoni	6-phosphofructokinase	0.0122	0.1389	0.1913
Brugia malayi	PHD-finger family protein	0.003	0.0123	0.0169
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0037	0.0221	0.0305
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.0163	0.0225
Plasmodium vivax	methionine--tRNA ligase, putative	0.0037	0.0221	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0352	0.0485
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0549	0.726	1
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0035	0.0048
Mycobacterium ulcerans	beta-lactamase	0.0117	0.132	0.6538
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0163	0.0225
Toxoplasma gondii	methionyl-tRNA synthetase	0.0037	0.0221	0.1676
Brugia malayi	6-phosphofructokinase	0.0122	0.1389	0.1913
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0037	0.0221	0.0221
Echinococcus multilocularis	sodium channel protein	0.0045	0.0333	0.0459
Schistosoma mansoni	hypothetical protein	0.0022	0.0009	0.0012
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.0628	0.0865
Entamoeba histolytica	acetyltransferase, GNAT family	0.0041	0.0277	0.0381
Loa Loa (eye worm)	aspartyl aminopeptidase	0.0549	0.726	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0427	0.0589
Schistosoma mansoni	6-phosphofructokinase	0.0122	0.1389	0.1913
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0163	0.0225
Plasmodium falciparum	methionine--tRNA ligase	0.0037	0.0221	0.0305
Echinococcus multilocularis	6 phosphofructokinase	0.0122	0.1389	0.1913
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0163	0.0225
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0035	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0049	0.038	0.0524
Trypanosoma brucei	hypothetical protein, conserved	0.0117	0.132	0.1818
Brugia malayi	Muscleblind-like protein	0.0533	0.7041	0.9698
Loa Loa (eye worm)	6-phosphofructokinase	0.0122	0.1389	0.1913
Echinococcus granulosus	6 phosphofructokinase	0.0122	0.1389	0.1913
Trichomonas vaginalis	conserved hypothetical protein	0.0257	0.3248	0.4474
Echinococcus granulosus	muscleblind protein	0.0533	0.7041	0.9698
Mycobacterium ulcerans	6-phosphofructokinase	0.0122	0.1389	0.688
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0427	0.0589
Plasmodium falciparum	M18 aspartyl aminopeptidase	0.0549	0.726	1
Schistosoma mansoni	bromodomain containing protein	0.007	0.068	0.0936
Brugia malayi	beta-NAC-like protein	0.0024	0.0035	0.0048
Schistosoma mansoni	transcription factor btf3	0.0024	0.0035	0.0048
Schistosoma mansoni	hypothetical protein	0.0179	0.217	0.2988
Trichomonas vaginalis	D-aminoacylase, putative	0.0117	0.132	0.1818
Mycobacterium ulcerans	hypothetical protein	0.0117	0.132	0.6538
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.0363	0.0499
Echinococcus multilocularis	methionine tRNA synthetase	0.0037	0.0221	0.0305
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0037	0.0221	0.0305
Mycobacterium leprae	PROBABLE AMINOPEPTIDASE PEPC	0.0549	0.726	1
Onchocerca volvulus		0.0117	0.132	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0151	0.1785	0.2458
Brugia malayi	acetyltransferase, GNAT family protein	0.0155	0.1848	0.2546
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0037	0.0221	0.0305
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0122	0.1389	0.1913
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.0277	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0045	0.0333	0.0459
Loa Loa (eye worm)	phosphofructokinase	0.0122	0.1389	0.1913
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0033	0.0163	0.1236
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0045	0.0333	0.0459
Loa Loa (eye worm)	bromodomain containing protein	0.0022	0.0017	0.0024
Brugia malayi	beta-lactamase	0.0117	0.132	0.1818
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0037	0.0221	0.1096
Brugia malayi	Bromodomain containing protein	0.0083	0.085	0.1171
Mycobacterium tuberculosis	Conserved protein	0.0117	0.132	0.132
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0117	0.132	0.1818
Trichomonas vaginalis	penicillin-binding protein, putative	0.0117	0.132	0.1818
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0117	0.132	0.1818
Trichomonas vaginalis	D-aminoacylase, putative	0.0117	0.132	0.1818
Loa Loa (eye worm)	6-phosphofructokinase	0.0122	0.1389	0.1913
Entamoeba histolytica	phosphofructokinase, putative	0.0122	0.1389	0.1913
Trichomonas vaginalis	hypothetical protein	0.0257	0.3248	0.4474
Echinococcus granulosus	methionine tRNA synthetase	0.0037	0.0221	0.0305
Toxoplasma gondii	NAC domain-containing protein	0.0024	0.0035	0.0264
Mycobacterium tuberculosis	Conserved protein	0.0117	0.132	0.132
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.0163	0.0225
Mycobacterium ulcerans	hypothetical protein	0.0168	0.2019	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0117	0.132	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0533	0.7041	0.9698
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0549	0.726	1
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0122	0.1389	0.1659
Mycobacterium ulcerans	lipase LipD	0.0117	0.132	0.6538
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0549	0.726	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0155	0.1848	0.2546
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0319	0.4094	0.564
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0122	0.1389	1
Entamoeba histolytica	phosphofructokinase, putative	0.0122	0.1389	0.1913
Leishmania major	ATP-dependent phosphofructokinase	0.0122	0.1389	0.1913
Mycobacterium tuberculosis	Probable lipase LipE	0.0117	0.132	0.132
Echinococcus multilocularis	survival motor neuron protein 1	0.0168	0.2026	0.2791
Leishmania major	methionyl-tRNA synthetase, putative	0.0037	0.0221	0.0305
Trichomonas vaginalis	penicillin-binding protein, putative	0.0117	0.132	0.1818
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0427	0.0589
Plasmodium vivax	basic transcription factor 3b, putative	0.0024	0.0035	0.0048
Loa Loa (eye worm)	hypothetical protein	0.004	0.0266	0.0367
Loa Loa (eye worm)	ICD-1 protein	0.0024	0.0035	0.0048
Echinococcus granulosus	aspartyl aminopeptidase	0.0549	0.726	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0231	0.0318
Schistosoma mansoni	hypothetical protein	0.0179	0.217	0.2988
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0122	0.1389	0.1913
Loa Loa (eye worm)	hypothetical protein	0.0549	0.726	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0122	0.1389	0.1389
Trypanosoma cruzi	transcription factor btf3, putative	0.0024	0.0035	0.0048
Trypanosoma brucei	transcription factor BTF3, putative	0.0024	0.0035	0.0048
Plasmodium vivax	hypothetical protein, conserved	0.0117	0.132	0.1818
Brugia malayi	beta-lactamase family protein	0.0117	0.132	0.1818
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0033	0.0163	0.5898
Trichomonas vaginalis	phosphofructokinase, putative	0.0122	0.1389	0.1913
Schistosoma mansoni	zinc finger protein	0.0024	0.0045	0.0062
Trypanosoma cruzi	hypothetical protein, conserved	0.0117	0.132	0.1818
Trichomonas vaginalis	phosphofructokinase, putative	0.0122	0.1389	0.1913
Brugia malayi	Aspartyl aminopeptidase	0.0549	0.726	1
Leishmania major	mitochondrial DNA polymerase beta	0.0319	0.4094	0.564
Echinococcus granulosus	geminin	0.0179	0.217	0.2988
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0155	0.1848	0.2546
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0427	0.0589
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0427	0.0589
Toxoplasma gondii	ABC1 family protein	0.0117	0.132	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0117	0.132	0.1818
Mycobacterium tuberculosis	Conserved protein	0.0117	0.132	0.132
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0326	0.0449
Mycobacterium leprae	Probable lipase LipE	0.0117	0.132	0.1561
Echinococcus multilocularis	microtubule associated protein 2	0.0467	0.6135	0.845
Trichomonas vaginalis	phosphofructokinase, putative	0.0122	0.1389	0.1913
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.0326	0.0449
Brugia malayi	Bromodomain containing protein	0.0044	0.0317	0.0437
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0047	0.0363	0.0499
Mycobacterium ulcerans	esterase/lipase LipP	0.0117	0.132	0.6538
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0047	0.0363	0.0499
Onchocerca volvulus		0.0117	0.132	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.0163	0.0225
Leishmania major	hypothetical protein, conserved	0.0117	0.132	0.1818
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0163	0.0225
Entamoeba histolytica	aminopeptidase, putative	0.0549	0.726	1
Trypanosoma cruzi	transcription factor btf3, putative	0.0024	0.0035	0.0048
Brugia malayi	6-phosphofructokinase	0.0122	0.1389	0.1913
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0037	0.0221	0.0305
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0163	0.0225
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0117	0.132	0.132
Entamoeba histolytica	hypothetical protein	0.0024	0.0035	0.0048
Schistosoma mansoni	hypothetical protein	0.0034	0.0182	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0117	0.132	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0117	0.132	0.1818
Leishmania major	basic transcription factor 3a, putative	0.0024	0.0035	0.0048
Echinococcus granulosus	sodium channel protein	0.0045	0.0333	0.0459
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0326	0.0449
Schistosoma mansoni	microtubule-associated protein tau	0.0467	0.6135	0.845
Loa Loa (eye worm)	hypothetical protein	0.0549	0.726	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0033	0.0163	0.5
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0319	0.4094	0.564
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0149	0.1755	0.2417
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.0461	0.0635
Trypanosoma cruzi	aspartyl aminopeptidase, putative	0.0549	0.726	1
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0257	0.3248	0.4474
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0009	0.0012
Echinococcus granulosus	survival motor neuron protein 1	0.0168	0.2026	0.2791
Echinococcus granulosus	zinc finger protein	0.0024	0.0045	0.0062
Toxoplasma gondii	6-phosphofructokinase	0.0033	0.0163	0.1236

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.0026 uM	Inhibition of human Nav1.7 expressed in HEK293 cells by PatchXpress method	ChEMBL.	25060923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3341987

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 935635