TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 666.839 | Formula: C36H58O11
H donors: 8 H acceptors: 9 LogP: 2.69 Rotable bonds: 5
Rule of 5 violations (Lipinski): 3
SMILES: OC[C@H]1O[C@@H](OC(=O)[C@@]23CCC(C[C@H]3C3=CC[C@H]4[C@@]([C@@]3(CC2)C)(C)C[C@@H](O)[C@@H]2[C@]4(C)C[C@H]([C@@H]([C@@]2(C)CO)O)O)(C)C)[C@@H]([C@H]([C@@H]1O)O)O
InChi: 1S/C36H58O11/c1-31(2)9-11-36(30(45)47-29-26(43)25(42)24(41)22(16-37)46-29)12-10-34(5)18(19(36)13-31)7-8-23-32(3)14-21(40)28(44)33(4,17-38)27(32)20(39)15-35(23,34)6/h7,19-29,37-44H,8-17H2,1-6H3/t19-,20+,21+,22+,23+,24+,25-,26+,27+,28-,29-,32+,33-,34+,35+,36-/m0/s1
InChiKey: DZVIFFMYEULLBY-ZBNHRINCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.1048	0.1031
Plasmodium falciparum	proliferation-associated protein 2g4, putative	0.0076	0.0812	0.0714
Toxoplasma gondii	hypothetical protein	0.0035	0.0105	0.0086
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0119	0.1542	0.1527
Onchocerca volvulus		0.0076	0.0812	0.0795
Echinococcus multilocularis	xaa Pro dipeptidase	0.0076	0.0812	0.0795
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.1198	0.1182
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0076	0.0812	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1347	0.1331
Echinococcus multilocularis	serotonin transporter	0.0205	0.3018	0.3005
Brugia malayi	hypothetical protein	0.0035	0.0105	0.0086
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0035	0.0105	0.0086
Echinococcus granulosus	methionyl aminopeptidase 2	0.0613	1	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.306	0.3047
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0119	0.1542	0.1542
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0664	0.0646
Onchocerca volvulus		0.0035	0.0105	0.0086
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0588	0.057
Loa Loa (eye worm)	serotonin transporter b	0.0205	0.3018	0.3005
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0194	0.0175
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0198	0.2903	0.2889
Mycobacterium ulcerans	beta-lactamase	0.004	0.0194	0.1121
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0119	0.1542	0.1527
Brugia malayi	beta-lactamase family protein	0.004	0.0194	0.0175
Mycobacterium ulcerans	hypothetical protein	0.004	0.0194	0.1121
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0076	0.0812	0.0714
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0613	1	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0035	0.0105	0.0105
Brugia malayi	Pre-SET motif family protein	0.0207	0.306	0.3047
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0194	0.1121
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0044	0.0025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1048	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1198	0.1182
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0194	0.0175
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0588	0.0588
Onchocerca volvulus		0.0035	0.0105	0.0086
Plasmodium falciparum	FACT complex subunit SPT16, putative	0.0076	0.0812	0.0714
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0588	0.057
Schistosoma mansoni	hypothetical protein	0.0031	0.0044	0.0025
Echinococcus multilocularis	FACT complex subunit SPT16	0.0076	0.0812	0.0795
Echinococcus multilocularis	xaa Pro dipeptidase	0.0076	0.0812	0.0795
Chlamydia trachomatis	aminopeptidase P	0.0076	0.0812	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0035	0.0105	0.0086
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0119	0.1542	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0194	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0105	0.0086
Plasmodium vivax	proliferation-associated protein 2g4, putative	0.0076	0.0812	0.0795
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0198	0.2903	0.2889
Trypanosoma brucei	carbonic anhydrase-like protein	0.0198	0.2903	0.2886
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Plasmodium vivax	ataxin-2 like protein, putative	0.0054	0.0427	0.0409
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0613	1	1
Mycobacterium ulcerans	dipeptidase PepE	0.0076	0.0812	0.519
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0076	0.0812	0.1676
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3018	0.3005
Leishmania major	hypothetical protein, conserved	0.0054	0.0427	0.0405
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1048	0.1031
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0035	0.0105	0.0086
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0613	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0588	0.057
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.1198	0.1182
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0035	0.0105	0.0086
Leishmania major	methionine aminopeptidase 2, putative	0.0613	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0044	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0588	0.057
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0613	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0044	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0588	0.057
Trypanosoma cruzi	aminopeptidase P1, putative	0.0076	0.0812	0.079
Toxoplasma gondii	methionine aminopeptidase	0.0076	0.0812	0.0795
Onchocerca volvulus		0.004	0.0194	0.0175
Plasmodium vivax	amine transporter, putative	0.0035	0.0105	0.0086
Loa Loa (eye worm)	hypothetical protein	0.004	0.0194	0.0175
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0107	0.1347	0.1331
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0194	0.0175
Brugia malayi	hypothetical protein	0.0054	0.0427	0.0409
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0613	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0198	0.2903	0.2889
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0076	0.0812	0.079
Mycobacterium tuberculosis	Dipeptidase PepE	0.0076	0.0812	0.1676
Schistosoma mansoni	carbonic anhydrase-related	0.0107	0.1347	0.1331
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0076	0.0812	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0076	0.0812	0.0795
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0076	0.0812	0.079
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0035	0.0105	0.0086
Brugia malayi	metallopeptidase family M24 containing protein	0.0076	0.0812	0.0795
Loa Loa (eye worm)	hypothetical protein	0.004	0.0194	0.0175
Loa Loa (eye worm)	norepinephrine transporter	0.0205	0.3018	0.3005
Loa Loa (eye worm)	hypothetical protein	0.004	0.0194	0.0175
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0545	0.3436
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3018	0.3005
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0076	0.0812	0.519
Schistosoma mansoni	hypothetical protein	0.0522	0.8442	0.8439
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0035	0.0105	0.0086
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0076	0.0812	0.0795
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.1048	0.1031
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0076	0.0812	0.0714
Echinococcus multilocularis	carbonic anhydrase	0.0107	0.1347	0.1331
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0613	1	1
Plasmodium falciparum	methionine aminopeptidase 2	0.0613	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.1198	0.1182
Toxoplasma gondii	hypothetical protein	0.0107	0.1347	0.1331
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Schistosoma mansoni	carbonic anhydrase	0.0107	0.1347	0.1331
Echinococcus granulosus	xaa Pro dipeptidase	0.0076	0.0812	0.0812
Onchocerca volvulus		0.0205	0.3018	0.3005
Echinococcus multilocularis	carbonic anhydrase	0.0107	0.1347	0.1331
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.0522	0.0504
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0076	0.0812	0.0795
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.1048	0.1048
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0035	0.0105	0.0086
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0513	0.0495
Leishmania major	aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0545	0.0528
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0105	0.0086
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0076	0.0812	0.0795
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0076	0.0812	1
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0513	0.0495
Echinococcus granulosus	geminin	0.0522	0.8442	0.8442
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0119	0.1542	0.1523
Loa Loa (eye worm)	CYP4Cod1	0.003	0.0023	0.0005
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0076	0.0812	0.0795
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0545	0.0545
Plasmodium vivax	FACT complex subunit SPT16, putative	0.0076	0.0812	0.0795
Wolbachia endosymbiont of Brugia malayi	Xaa-Pro aminopeptidase	0.0076	0.0812	0.5
Brugia malayi	Cytochrome P450 family protein	0.003	0.0023	0.0005
Brugia malayi	metallopeptidase family M24 containing protein	0.0076	0.0812	0.0795
Echinococcus granulosus	methionine aminopeptidase type I	0.0076	0.0812	0.0812
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0545	0.0528
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0107	0.1347	0.1331
Brugia malayi	TAR-binding protein	0.0063	0.0588	0.057
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0105	0.0086
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0613	1	1
Treponema pallidum	sodium- and chloride- dependent transporter	0.0205	0.3018	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0194	0.0175
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0194	0.0175
Schistosoma mansoni	sodium/chloride dependent transporter	0.0035	0.0105	0.0086
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0035	0.0105	0.0086
Echinococcus multilocularis	ankyrin repeat protein	0.0336	0.5268	0.5259
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Schistosoma mansoni	hypothetical protein	0.0067	0.0664	0.0646
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0044	0.0044
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0035	0.0105	0.0086
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0076	0.0812	0.079
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0545	0.0528
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0194	0.0175
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0076	0.0812	0.079
Toxoplasma gondii	ABC1 family protein	0.004	0.0194	0.0175
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.0513	0.0495
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0194	0.0171
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0076	0.0812	0.0795
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0427	0.0405
Echinococcus multilocularis	transient receptor potential cation channel	0.0347	0.5453	0.5444
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0076	0.0812	0.0795
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0588	0.057
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0513	0.0495
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Mycobacterium ulcerans	aminopeptidase	0.0076	0.0812	0.519
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0545	0.0523
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0035	0.0105	0.0086
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0076	0.0812	0.1676
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0613	1	1
Toxoplasma gondii	proliferation-associated protein 2G4, putative	0.0076	0.0812	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0664	0.0646
Loa Loa (eye worm)	carbonic anhydrase 3	0.0198	0.2903	0.2889
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Plasmodium vivax	peptidase, putative	0.0076	0.0812	0.0795
Brugia malayi	metallopeptidase family M24 containing protein	0.0076	0.0812	0.0795
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0076	0.0812	0.0795
Plasmodium falciparum	carbonic anhydrase	0.0107	0.1347	0.1255
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0198	0.2903	0.2886
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0023	0.0005
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0076	0.0812	0.0795
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.1048	0.1031
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0076	0.0812	0.079
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0035	0.0105	0.0086
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0076	0.0812	0.079
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0035	0.0105	0.0086
Echinococcus granulosus	FACT complex subunit SPT16	0.0076	0.0812	0.0812
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0076	0.0812	0.0795
Plasmodium vivax	methionine aminopeptidase 1c, putative	0.0076	0.0812	0.0795
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0076	0.0812	0.0795
Brugia malayi	beta-lactamase	0.004	0.0194	0.0175
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0255	0.3882	1
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Brugia malayi	Cytochrome P450 family protein	0.003	0.0023	0.0005
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0035	0.0105	0.0086
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0198	0.2903	0.2889
Mycobacterium ulcerans	dipeptidase	0.0076	0.0812	0.519
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.1048	0.1048
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0119	0.1542	0.3657
Trypanosoma brucei	methionine aminopeptidase, putative	0.0076	0.0812	0.079
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0105	0.0086
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0545	0.3436
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0613	1	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0035	0.0105	0.0086
Echinococcus granulosus	xaa Pro dipeptidase	0.0076	0.0812	0.0812
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.3551	0.3423
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0076	0.0812	0.0795
Leishmania major	hypothetical protein, conserved	0.0076	0.0812	0.079
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0588	0.057
Toxoplasma gondii	creatinase domain-containing protein	0.0076	0.0812	0.0795
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0035	0.0105	0.0105
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0076	0.0812	0.5
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0076	0.0812	0.0795
Leishmania major	hypothetical protein, conserved	0.004	0.0194	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0427	0.0409
Giardia lamblia	Methionine aminopeptidase	0.0613	1	1
Brugia malayi	hypothetical protein	0.0035	0.0102	0.0083
Schistosoma mansoni	hypothetical protein	0.0107	0.1347	0.1331
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0035	0.0105	0.0086
Plasmodium falciparum	aminopeptidase P	0.0076	0.0812	0.0714
Onchocerca volvulus	Dipeptidase C homolog	0.0076	0.0812	0.0795
Echinococcus granulosus	sodium and chloride dependent glycine	0.0035	0.0105	0.0105
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0427	0.0326
Mycobacterium leprae	Probable cytoplasmic peptidase PepQ	0.0076	0.0812	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0035	0.0105	0.0086
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0513	0.0495
Trypanosoma brucei	PAB1-binding protein , putative	0.0054	0.0427	0.0405
Echinococcus multilocularis	xaa pro aminopeptidase	0.0076	0.0812	0.0795
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.0076	0.0812	0.079
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1347	0.1331
Schistosoma mansoni	hypothetical protein	0.0031	0.0044	0.0025
Brugia malayi	jmjC domain containing protein	0.0059	0.0513	0.0495
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0035	0.0105	0.0086
Toxoplasma gondii	methionine aminopeptidase	0.0076	0.0812	0.0795
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0545	0.0528
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0545	0.0954
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0035	0.0105	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0105	0.0086
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0076	0.0812	0.079
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0076	0.0812	0.0795
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0194	0.0194
Onchocerca volvulus		0.004	0.0194	0.0175
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0545	0.3436
Schistosoma mansoni	sodium/chloride dependent transporter	0.0205	0.3018	0.3005
Echinococcus granulosus	carbonic anhydrase	0.0107	0.1347	0.1347
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0107	0.1347	0.1331
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0035	0.0105	0.0105
Toxoplasma gondii	peptidase D, putative	0.0076	0.0812	0.0795
Echinococcus multilocularis	carbonic anhydrase	0.0107	0.1347	0.1331
Onchocerca volvulus	FACT complex subunit SPT16 homolog	0.0076	0.0812	0.0795
Brugia malayi	Cytochrome P450 family protein	0.0059	0.0522	0.0504
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0198	0.2903	0.2886
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0035	0.0105	0.0105
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0035	0.0105	0.0086
Brugia malayi	jmjC domain containing protein	0.0059	0.0513	0.0495
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0076	0.0812	0.0795
Schistosoma mansoni	carbonic anhydrase-related	0.0107	0.1347	0.1331
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0107	0.1347	0.1331
Echinococcus granulosus	GPCR family 2	0.0031	0.0044	0.0044
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0076	0.0812	0.0795
Mycobacterium ulcerans	lipase LipD	0.004	0.0194	0.1121
Echinococcus granulosus	serotonin transporter	0.0205	0.3018	0.3018
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0105	0.0086
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0613	1	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0198	0.2903	0.2889
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0194	0.0175
Echinococcus multilocularis	geminin	0.0522	0.8442	0.8439
Loa Loa (eye worm)	DNA-binding protein	0.0076	0.0812	0.0795
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0107	0.1347	0.1331
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0588	0.057
Mycobacterium tuberculosis	Probable cytoplasmic peptidase PepQ	0.0076	0.0812	0.1676
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0035	0.0105	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1347	0.1331
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1048	0.1031
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0205	0.3018	0.3005
Loa Loa (eye worm)	hypothetical protein	0.004	0.0194	0.0175
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0107	0.1344	0.1328
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0019	0.0019
Toxoplasma gondii	hypothetical protein	0.0035	0.0105	0.0086
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0588	0.057
Mycobacterium ulcerans	methionine aminopeptidase	0.0076	0.0812	0.519
Toxoplasma gondii	LsmAD domain-containing protein	0.0054	0.0427	0.0409
Echinococcus granulosus	carbonic anhydrase	0.0107	0.1347	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0812	0.0795
Toxoplasma gondii	transcriptional elongation factor FACT140	0.0076	0.0812	0.0795
Schistosoma mansoni	peptidase	0.0076	0.0812	0.0795
Mycobacterium ulcerans	cytoplasmic peptidase PepQ	0.0076	0.0812	0.519
Onchocerca volvulus		0.0237	0.356	0.3548
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0427	0.0326
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0035	0.0105	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3018	0.3005
Echinococcus multilocularis	carbonic anhydrase II	0.0198	0.2903	0.2889
Echinococcus granulosus	carbonic anhydrase II	0.0198	0.2903	0.2903
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0076	0.0812	0.0812
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0194	0.0171
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0336	0.5268	0.5259
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.0513	0.0513
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0194	0.0171
Schistosoma mansoni	carbonic anhydrase-related	0.0107	0.1347	0.1331
Loa Loa (eye worm)	beta-lactamase	0.004	0.0194	0.0175
Echinococcus granulosus	ankyrin repeat protein	0.0336	0.5268	0.5268
Brugia malayi	beta-lactamase family protein	0.004	0.0194	0.0175
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0119	0.1542	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0812	0.0795
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0076	0.0812	0.0812
Echinococcus granulosus	carbonic anhydrase	0.0107	0.1347	0.1347
Leishmania major	transcription factor-like protein	0.0076	0.0812	0.079
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.0513	0.0513
Trypanosoma cruzi	aminopeptidase P, putative	0.0076	0.0812	0.079
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0613	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0044	0.0025
Schistosoma mansoni	hypothetical protein	0.0031	0.0044	0.0025
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0427	0.0405
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0076	0.0812	0.079
Brugia malayi	Methionine aminopeptidase protein type I	0.0076	0.0812	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0105	0.0086
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0044	0.0025
Schistosoma mansoni	sodium/chloride dependent transporter	0.0035	0.0105	0.0086
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0205	0.3018	0.3005
Schistosoma mansoni	hypothetical protein	0.0031	0.0044	0.0025
Onchocerca volvulus		0.0035	0.0105	0.0086
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0119	0.1542	0.1527
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0044	0.0025
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.0513	0.0495
Echinococcus granulosus	sodium and chloride dependent glycine	0.0035	0.0105	0.0105
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.1048	0.1031
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0613	1	1
Plasmodium falciparum	methionine aminopeptidase 1c, putative	0.0076	0.0812	0.0714
Schistosoma mansoni	hypothetical protein	0.0522	0.8442	0.8439
Echinococcus granulosus	xaa pro aminopeptidase	0.0076	0.0812	0.0812
Onchocerca volvulus		0.004	0.0194	0.0175
Echinococcus granulosus	Proliferation associated protein 2G4	0.0076	0.0812	0.0812
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0107	0.1347	0.1331
Echinococcus granulosus	transient receptor potential cation channel	0.0347	0.5444	0.5444
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0076	0.0812	0.079
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0812	0.0795
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0076	0.0812	0.0795
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0205	0.3018	0.3005
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0023	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0105	0.0086
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0076	0.0812	0.0795
Leishmania major	carbonic anhydrase-like protein	0.0198	0.2903	0.2886
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0194	0.1121
Chlamydia trachomatis	methionine aminopeptidase	0.0076	0.0812	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0044	0.0044
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0035	0.0105	0.0086
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0613	1	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0076	0.0812	0.063
Entamoeba histolytica	methionine aminopeptidase, putative	0.0613	1	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0035	0.0105	0.0086
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0044	0.0025
Brugia malayi	RNA binding protein	0.0063	0.0588	0.057
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0613	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0588	0.057

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 50 ug ml-1	Antifungal activity against Candida albicans ATCC 90028	ChEMBL.	12502337
IC50 (functional)	> 50 ug ml-1	Antifungal activity against Cryptococcus neoformans ATCC 90113	ChEMBL.	12502337

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL391767

Bibliographic References

No literature references available for this target.

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Detailed information for compound 938155