Detailed information for compound 941356

Basic information

Technical information
  • TDR Targets ID: 941356
  • Name: MOLI000230
  • MW: 294.442 | Formula: C19H21NS
  • H donors: 0 H acceptors: 0 LogP: 4.28 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [11CH3]Sc1ccc(cc1)[C@@H]1CN2CCC[C@@H]2c2c1cccc2
  • InChi: 1S/C19H21NS/c1-21-15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3/t18-,19+/m0/s1/i1-1
  • InChiKey: YVKDUIAAPBKHMJ-AANZQFEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MOLI001657

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide s receptor 0.0684 0.2487 0.3582
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Trypanosoma cruzi ion transport protein, putative 0.0054 0.0092 0.0293
Entamoeba histolytica hypothetical protein 0.0073 0.0164 1
Schistosoma mansoni biogenic amine receptor 0.0136 0.0403 0.0733
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0054 0.0092 0.0132
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0136 0.0405 0.0584
Brugia malayi CLC chloride channel protein 0.0037 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis fibrillin 1 0.0081 0.0194 0.0279
Schistosoma mansoni growth hormone secretagogue receptor 0.0136 0.0403 0.0733
Brugia malayi EGF-like domain containing protein 0.0081 0.0194 0.0194
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0136 0.0403 0.058
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0655 0.5831
Echinococcus multilocularis geminin 0.017 0.0532 0.0766
Brugia malayi EGF-like domain containing protein 0.0081 0.0194 0.0194
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0037 0.0027 0.0012
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0136 0.0405 0.0584
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0136 0.0405 0.0405
Brugia malayi G-protein coupled receptor 0.0136 0.0403 0.0403
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0024 0.0035
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0037 0.0027 0.0039
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0136 0.0403 0.0403
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0037 0.0027 0.0049
Schistosoma mansoni chloride channel protein 0.0037 0.0027 0.0049
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0136 0.0403 0.0403
Plasmodium vivax amine transporter, putative 0.0136 0.0405 0.1835
Echinococcus multilocularis adam 0.0081 0.0194 0.0279
Onchocerca volvulus 0.0136 0.0403 0.1369
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0054 0.0092 0.0092
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0136 0.0403 0.0733
Toxoplasma gondii ion channel protein 0.0054 0.0092 0.0305
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis dro:myosuppressin receptor 0.0136 0.0403 0.058
Schistosoma mansoni opsin-like receptor 0.0136 0.0403 0.0733
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0136 0.0403 0.058
Echinococcus multilocularis sodium and chloride dependent glycine 0.0136 0.0405 0.0584
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.012 0.0173
Echinococcus granulosus sodium and chloride dependent glycine 0.0136 0.0405 0.0584
Echinococcus granulosus tachykinin peptides receptor 99D 0.0136 0.0403 0.058
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0619 0.2243 0.2243
Giardia lamblia Tenascin-37 0.0081 0.0194 1
Schistosoma mansoni hypothetical protein 0.0136 0.0403 0.0733
Schistosoma mansoni hypothetical protein 0.0073 0.0164 0.0298
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0091 0.0091
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0081 0.0194 0.1057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.012 0.0421
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0136 0.0405 0.0738
Echinococcus granulosus tm gpcr rhodopsin 0.0136 0.0403 0.058
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0136 0.0405 0.0405
Brugia malayi EGF-like domain containing protein 0.0081 0.0194 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0136 0.0405 0.0584
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.0403 0.058
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0149 0.0149
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0136 0.0403 0.058
Giardia lamblia Neurogenic locus Notch protein precursor 0.0081 0.0194 1
Schistosoma mansoni myosin xvIII 0.0136 0.0403 0.0733
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0136 0.0403 0.0733
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Schistosoma mansoni twik family of potassium channels-related 0.0054 0.0092 0.0167
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0149 0.0149
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0136 0.0403 0.0733
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0583 0.2103 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0405 0.0405
Loa Loa (eye worm) TWK-7 protein 0.0054 0.0092 0.0092
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.012 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Loa Loa (eye worm) hypothetical protein 0.0237 0.0787 0.0787
Schistosoma mansoni biogenic amine receptor 0.0136 0.0403 0.0733
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0136 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0136 0.0405 0.0405
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0619 0.2243 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Echinococcus granulosus geminin 0.017 0.0532 0.0766
Echinococcus granulosus neuropeptides capa receptor 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0027 0.0027
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.012 0.0421
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Toxoplasma gondii IMP dehydrogenas 0.0619 0.2243 1
Loa Loa (eye worm) hypothetical protein 0.0554 0.1994 0.1994
Echinococcus granulosus biogenic amine 5HT receptor 0.0136 0.0403 0.058
Schistosoma mansoni neuropeptide receptor 0.0136 0.0403 0.0733
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0024 0.0035
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0257 0.0866 0.0866
Entamoeba histolytica hypothetical protein 0.0073 0.0164 1
Echinococcus granulosus tm gpcr rhodopsin 0.0136 0.0403 0.058
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0054 0.0092 0.0092
Echinococcus multilocularis somatostatin receptor 0.0136 0.0403 0.058
Echinococcus multilocularis neuropeptide FF receptor 2 0.0136 0.0403 0.058
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0037 0.0027 0.0049
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1057 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0027 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0136 0.0403 0.0403
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0162 0.0233
Brugia malayi ancient conserved domain protein 4 0.0037 0.0027 0.0027
Brugia malayi follicle stimulating hormone receptor 0.0136 0.0403 0.0403
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.0403 0.058
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.0403 0.058
Loa Loa (eye worm) kelch domain-containing protein family protein 0.038 0.1334 0.1334
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0136 0.0405 0.0405
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0619 0.2243 0.323
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0162 0.061
Echinococcus granulosus neuropeptide Y receptor 0.0136 0.0403 0.058
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0054 0.0092 0.0132
Echinococcus granulosus orexin receptor type 2 0.0136 0.0403 0.058
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0164 0.0298
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0162 0.061
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1057 1
Loa Loa (eye worm) norepinephrine transporter 0.0803 0.2941 0.2941
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Schistosoma mansoni twik family of potassium channels-related 0.0054 0.0092 0.0167
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0843 0.0843
Brugia malayi chloride channel protein 7 0.0037 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Schistosoma mansoni amine GPCR 0.0136 0.0403 0.0733
Brugia malayi hypothetical protein 0.0054 0.0092 0.0092
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0619 0.2243 1
Schistosoma mansoni amine GPCR 0.0136 0.0403 0.0733
Brugia malayi Voltage gated chloride channel family protein 0.0037 0.0027 0.0027
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0136 0.0403 0.0733
Echinococcus granulosus g-protein coupled receptor 0.0136 0.0403 0.058
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0136 0.0403 0.0403
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.0403 0.058
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0136 0.0403 0.058
Brugia malayi Melatonin receptor type 1A 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0069 0.0149 0.0149
Onchocerca volvulus 0.0136 0.0403 0.1369
Echinococcus granulosus hypothetical protein 0.0136 0.0403 0.058
Loa Loa (eye worm) uncoordinated protein 58 0.0054 0.0092 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0092 0.0293
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Echinococcus granulosus somatostatin receptor 0.0136 0.0403 0.058
Onchocerca volvulus 0.0136 0.0405 0.1378
Mycobacterium ulcerans ion transport protein 0.0054 0.0092 0.0293
Echinococcus multilocularis serotonin transporter 0.0803 0.2941 0.4237
Schistosoma mansoni twik family of potassium channels-related 0.0054 0.0092 0.0167
Loa Loa (eye worm) hypothetical protein 0.0136 0.0405 0.0405
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0024 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.0403 0.058
Echinococcus multilocularis fmrfamide receptor 0.0136 0.0403 0.058
Loa Loa (eye worm) chloride channel protein 7 0.0037 0.0027 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0162 0.0295
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Trichomonas vaginalis hypothetical protein 0.0081 0.0194 0.1057
Schistosoma mansoni hypothetical protein 0.0054 0.0092 0.0167
Loa Loa (eye worm) TWK-28 protein 0.0054 0.0092 0.0092
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0136 0.0403 0.0733
Echinococcus granulosus neuropeptide receptor 0.0136 0.0403 0.058
Schistosoma mansoni hypothetical protein 0.0136 0.0403 0.0733
Onchocerca volvulus Neuropeptide F receptor homolog 0.0136 0.0403 0.1369
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0164 0.0236
Echinococcus multilocularis twik family of potassium channels 0.0054 0.0092 0.0132
Echinococcus multilocularis small conductance calcium activated potassium 0.1227 0.4555 0.6561
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0136 0.0405 0.0738
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0054 0.0092 0.0092
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0136 0.0403 0.0403
Echinococcus multilocularis GPCR, family 2 0.0069 0.0149 0.0215
Schistosoma mansoni opsin-like receptor 0.0136 0.0403 0.0733
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0149 0.0215
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0.0223 0.1356
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0149 0.0215
Echinococcus granulosus GPCR family 2 0.0069 0.0149 0.0215
Brugia malayi ORL1-like opioid receptor 0.0136 0.0403 0.0403
Onchocerca volvulus 0.0136 0.0403 0.1369
Onchocerca volvulus Glucosylceramidase homolog 0.0202 0.0655 0.2226
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0308 0.1057 0.1057
Schistosoma mansoni hypothetical protein 0.1227 0.4555 0.8289
Loa Loa (eye worm) hypothetical protein 0.0081 0.0194 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Echinococcus granulosus peptide allatostatin:somatostatin 0.0136 0.0403 0.058
Echinococcus granulosus potassium channel subfamily K 8 0.0054 0.0092 0.0132
Schistosoma mansoni twik family of potassium channels-related 0.0054 0.0092 0.0167
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0054 0.0092 0.0092
Loa Loa (eye worm) neuropeptide F receptor 0.0136 0.0403 0.0403
Schistosoma mansoni voltage-gated potassium channel 0.004 0.004 0.0072
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0619 0.2243 1
Loa Loa (eye worm) integrin beta-2 0.2504 0.9412 0.9412
Onchocerca volvulus 0.0136 0.0403 0.1369
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0325 0.1124 0.4951
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Leishmania major inosine-5-monophosphate dehydrogenase 0.0619 0.2243 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0136 0.0403 0.058
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0619 0.2243 0.323
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0136 0.0403 0.0403
Brugia malayi Serotonin receptor 0.0136 0.0403 0.0403
Onchocerca volvulus 0.0136 0.0403 0.1369
Brugia malayi Dopamine receptor protein 1 0.0136 0.0403 0.0403
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0.0223 0.1356
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0696 0.626
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0655 0.5831
Echinococcus granulosus fibrillin 2 0.0081 0.0194 0.0279
Onchocerca volvulus 0.0054 0.0092 0.0312
Onchocerca volvulus 0.0054 0.0092 0.0312
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0069 0.0149 0.0272
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.012 0.0421
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1057 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0111 0.016
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0081 0.0194 0.0194
Leishmania major calcium/potassium channel (CAKC), putative 0.0054 0.0092 0.0293
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0111 0.0202
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0037 0.0027 0.0039
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0136 0.0405 1
Schistosoma mansoni hypothetical protein 0.017 0.0532 0.0968
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0136 0.0405 0.0584
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Brugia malayi neuropeptide F receptor 0.0136 0.0403 0.0403
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.0403 0.058
Brugia malayi Kelch motif family protein 0.038 0.1334 0.1334
Loa Loa (eye worm) hypothetical protein 0.038 0.1334 0.1334
Plasmodium falciparum potassium channel 0.0054 0.0092 0.0313
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis g protein coupled receptor 0.0136 0.0403 0.058
Schistosoma mansoni hypothetical protein 0.0052 0.0084 0.0152
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Schistosoma mansoni integrin beta subunit 0.1474 0.5496 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0024 0.0024
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0136 0.0405 0.0738
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0136 0.0405 0.1719
Echinococcus granulosus potassium channel subfamily K 0.0054 0.0092 0.0132
Schistosoma mansoni twik family of potassium channels-related 0.0054 0.0092 0.0167
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0655 0.5831
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0054 0.0092 0.0092
Echinococcus multilocularis protein jagged 2 0.0081 0.0194 0.0279
Onchocerca volvulus 0.0136 0.0403 0.1369
Echinococcus multilocularis g protein coupled receptor 0.0136 0.0403 0.058
Onchocerca volvulus 0.0048 0.0071 0.024
Schistosoma mansoni neuropeptide F-like receptor 0.0136 0.0403 0.0733
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0054 0.0092 0.0092
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0294 0.1006 0.4418
Giardia lamblia Tenascin-like 0.0081 0.0194 1
Echinococcus multilocularis twik family of potassium channels 0.0054 0.0092 0.0132
Onchocerca volvulus 0.0803 0.2941 1
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0162 0.0622
Schistosoma mansoni amine GPCR 0.0136 0.0403 0.0733
Schistosoma mansoni hypothetical protein 0.0136 0.0403 0.0733
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0136 0.0405 0.1719
Brugia malayi Pre-SET motif family protein 0.0036 0.0024 0.0024
Echinococcus multilocularis sex peptide receptor 0.0136 0.0403 0.058
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0136 0.0403 0.058
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0136 0.0405 0.0738
Loa Loa (eye worm) hypothetical protein 0.0037 0.0027 0.0027
Schistosoma mansoni adenoreceptor 0.0136 0.0403 0.0733
Brugia malayi ancient conserved domain protein 2 0.0037 0.0027 0.0027
Echinococcus granulosus calcium activated potassium channel variant 0.0054 0.0092 0.0132
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0164 0.0236
Onchocerca volvulus 0.0136 0.0403 0.1369
Echinococcus multilocularis neuropeptides capa receptor 0.0136 0.0403 0.058
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0655 0.5831
Echinococcus multilocularis calcium activated potassium channel variant 0.0054 0.0092 0.0132
Schistosoma mansoni sodium/chloride dependent transporter 0.0803 0.2941 0.5352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0136 0.0405 0.0584
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.012 0.0173
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0167 0.0241
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0136 0.0403 0.058
Loa Loa (eye worm) TYRA-2 protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0136 0.0405 0.0405
Schistosoma mansoni neuropeptide F-like receptor 0.0136 0.0403 0.0733
Onchocerca volvulus 0.0136 0.0403 0.1369
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0655 0.5831
Loa Loa (eye worm) G-protein coupled receptor 0.0136 0.0403 0.0403
Schistosoma mansoni hypothetical protein 0.0069 0.0149 0.0272
Echinococcus granulosus tm gpcr rhodopsin 0.0136 0.0403 0.058
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0294 0.1006 0.4418
Giardia lamblia hypothetical protein 0.0081 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0111 0.016
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.012 0.0421
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Schistosoma mansoni hypothetical protein 0.0069 0.0149 0.0272
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0054 0.0092 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.0403 0.058
Leishmania major potassium channel subunit-like protein 0.0054 0.0092 0.0293
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0054 0.0092 0.0132
Schistosoma mansoni neuropeptide receptor 0.0136 0.0403 0.0733
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Entamoeba histolytica hypothetical protein 0.0073 0.0164 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0619 0.2243 1
Brugia malayi G protein-coupled receptor 0.0136 0.0403 0.0403
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.0717 0.0717
Toxoplasma gondii CBS domain-containing protein 0.0037 0.0027 0.0012
Echinococcus multilocularis potassium channel subfamily K 8 0.0054 0.0092 0.0132
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi hypothetical protein 0.0136 0.0405 0.0405
Loa Loa (eye worm) loechrig isoform VII 0.0037 0.0027 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.0403 0.058
Onchocerca volvulus 0.0037 0.0027 0.0091
Brugia malayi Dopamine receptor 0.0136 0.0403 0.0403
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0136 0.0405 0.0738
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0054 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Onchocerca volvulus 0.0136 0.0403 0.1369
Loa Loa (eye worm) hypothetical protein 0.0136 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.0027 0.0027
Brugia malayi jmjC domain containing protein 0.0059 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.0454 0.0454
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0054 0.0092 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.0403 0.058
Echinococcus multilocularis potassium channel subfamily K 8 0.0054 0.0092 0.0132
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0054 0.0092 0.0092
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0037 0.0027 0.0039
Brugia malayi RE15519p 0.0136 0.0403 0.0403
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis sodium and chloride dependent glycine 0.0136 0.0405 0.0584
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0092 0.0293
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Trypanosoma cruzi GMP reductase 0.0619 0.2243 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0136 0.0403 0.058
Onchocerca volvulus 0.0136 0.0403 0.1369
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0136 0.0403 0.0733
Giardia lamblia Tenascin precursor 0.0081 0.0194 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0024 0.0044
Leishmania major hypothetical protein, conserved 0.0054 0.0092 0.0293
Echinococcus granulosus sex peptide receptor 0.0136 0.0403 0.058
Echinococcus granulosus twik family of potassium channels 0.0054 0.0092 0.0132
Echinococcus granulosus g protein coupled receptor 0.0136 0.0403 0.058
Echinococcus granulosus neuropeptide Y receptor 0.0136 0.0403 0.058
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0054 0.0092 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1057 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.0403 0.058
Brugia malayi hypothetical protein 0.038 0.1334 0.1334
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0162 0.0233
Plasmodium falciparum potassium channel 0.0054 0.0092 0.0313
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Echinococcus multilocularis potassium channel subfamily K 0.0054 0.0092 0.0132
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0136 0.0403 0.058
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0037 0.0027 0.0039
Schistosoma mansoni calcium-activated potassium channel 0.0906 0.3334 0.6066
Onchocerca volvulus 0.0054 0.0092 0.0312
Echinococcus granulosus potassium channel subfamily K 8 0.0054 0.0092 0.0132
Brugia malayi EGF-like domain containing protein 0.0081 0.0194 0.0194
Brugia malayi Pre-SET motif family protein 0.0251 0.0843 0.0843
Echinococcus multilocularis integrin beta 2 0.1855 0.6943 1
Echinococcus multilocularis fmrfamide receptor 0.0136 0.0403 0.058
Schistosoma mansoni hypothetical protein 0.0069 0.0149 0.0272
Schistosoma mansoni calcium-activated potassium channel 0.0054 0.0092 0.0167
Schistosoma mansoni neuropeptide receptor 0.0136 0.0403 0.0733
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Toxoplasma gondii CBS family protein 0.0037 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Entamoeba histolytica hypothetical protein 0.0073 0.0164 1
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.0787 0.1134
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Schistosoma mansoni hypothetical protein 0.0149 0.0454 0.0826
Plasmodium vivax potassium channel, putative 0.0054 0.0092 0.0326
Echinococcus multilocularis neuropeptide Y receptor 0.0136 0.0403 0.058
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0037 0.0027 0.0039
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0054 0.0092 0.0293
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0136 0.0405 0.1719
Echinococcus granulosus fmrfamide receptor 0.0136 0.0403 0.058
Echinococcus granulosus g protein coupled receptor 0.0136 0.0403 0.058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0136 0.0403 0.0733
Brugia malayi CBS domain containing protein 0.0037 0.0027 0.0027
Onchocerca volvulus 0.0136 0.0405 0.1378
Toxoplasma gondii CBS domain-containing protein 0.0037 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis G-protein coupled receptor, putative 0.0136 0.0403 0.058
Onchocerca volvulus 0.0054 0.0092 0.0312
Echinococcus granulosus dro:myosuppressin receptor 0.0136 0.0403 0.058
Schistosoma mansoni neuropeptide receptor 0.0136 0.0403 0.0733
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0136 0.0405 0.0738
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.0717 0.0717
Echinococcus granulosus G protein coupled receptor 139 0.0136 0.0403 0.058
Echinococcus multilocularis fibrillin 2 0.0081 0.0194 0.0279
Echinococcus multilocularis serotonin receptor 0.0136 0.0403 0.058
Brugia malayi hypothetical protein 0.0237 0.0787 0.0787
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0619 0.2243 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0405 0.0405
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0136 0.0403 0.058
Toxoplasma gondii hypothetical protein 0.0136 0.0405 0.1719
Onchocerca volvulus Putative GMP reductase 0.0257 0.0866 0.2944
Brugia malayi neuropeptide F receptor 0.0136 0.0403 0.0403
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.0787 0.1134
Loa Loa (eye worm) hypothetical protein 0.0803 0.2941 0.2941
Brugia malayi GnHR receptor homolog 0.0136 0.0403 0.0403
Echinococcus granulosus small conductance calcium activated potassium 0.1227 0.4555 0.6561
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0136 0.0403 0.0403
Brugia malayi putative neuropeptide receptor NPR1 0.0136 0.0403 0.0403
Brugia malayi GMP reductase 0.0257 0.0866 0.0866
Onchocerca volvulus 0.0136 0.0403 0.1369
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0136 0.0403 0.0733
Echinococcus granulosus biogenic amine 5HT receptor 0.0136 0.0403 0.058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0149 0.0215
Echinococcus granulosus fibrillin 1 0.0081 0.0194 0.0279
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.0717 0.0717
Echinococcus granulosus alpha 1A adrenergic receptor 0.0136 0.0403 0.058
Echinococcus multilocularis neuropeptides capa receptor 0.0136 0.0403 0.058
Brugia malayi hypothetical protein 0.0054 0.0092 0.0092
Echinococcus multilocularis orexin receptor type 2 0.0136 0.0403 0.058
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0111 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0149 0.0215
Schistosoma mansoni twik family of potassium channels-related 0.0054 0.0092 0.0167
Loa Loa (eye worm) hypothetical protein 0.0081 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0037 0.0027 0.0027
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0583 0.2103 0.9369
Plasmodium falciparum amino acid transporter, putative 0.0136 0.0405 0.1824
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0136 0.0403 0.058
Schistosoma mansoni calcium-activated potassium channel 0.0054 0.0092 0.0167
Echinococcus granulosus neuropeptide receptor A26 0.0684 0.2487 0.3582
Schistosoma mansoni hypothetical protein 0.0048 0.0071 0.0128
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0136 0.0403 0.058
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0037 0.0027 0.0039
Onchocerca volvulus 0.0054 0.0092 0.0312
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0136 0.0403 0.0733
Echinococcus granulosus H:Cl exchange transporter 7 0.0037 0.0027 0.0039
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0136 0.0403 0.0733
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0136 0.0403 0.0733
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0975 0.915
Echinococcus multilocularis neuropeptide receptor A26 0.0684 0.2487 0.3582
Treponema pallidum sodium- and chloride- dependent transporter 0.0803 0.2941 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0054 0.0092 0.0092
Onchocerca volvulus 0.0136 0.0405 0.1378
Giardia lamblia Hypothetical protein 0.0054 0.0092 0.3892
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0054 0.0092 0.0293
Brugia malayi loechrig isoform VII 0.0037 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Onchocerca volvulus 0.0054 0.0092 0.0312
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0167 0.0241
Brugia malayi hypothetical protein 0.0136 0.0403 0.0403
Schistosoma mansoni alpha-1 adrenergic receptor 0.0136 0.0403 0.0733
Plasmodium falciparum transporter, putative 0.0136 0.0405 0.1824
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0136 0.0403 0.058
Loa Loa (eye worm) solute carrier family 6 member 4 0.0803 0.2941 0.2941
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0162 0.061
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0308 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0803 0.2941 0.2941
Brugia malayi larval opioid receptor 0.0136 0.0403 0.0403
Echinococcus granulosus neuropeptide FF receptor 2 0.0136 0.0403 0.058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Schistosoma mansoni hypothetical protein 0.017 0.0532 0.0968
Echinococcus granulosus g protein coupled receptor 0.0136 0.0403 0.058
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0054 0.0092 0.0293
Schistosoma mansoni histamine h1 receptor 0.0136 0.0403 0.0733
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0325 0.1124 0.4951
Mycobacterium ulcerans transmembrane cation transporter 0.0054 0.0092 0.0293
Echinococcus granulosus adam 0.0081 0.0194 0.0279
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0037 0.0027 0.0039
Loa Loa (eye worm) hypothetical protein 0.0352 0.1227 0.1227
Echinococcus granulosus sodium and chloride dependent glycine 0.0136 0.0405 0.0584
Schistosoma mansoni amine GPCR 0.0136 0.0403 0.0733
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0136 0.0403 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0024 0.0044
Onchocerca volvulus 0.0081 0.0194 0.0659
Loa Loa (eye worm) hypothetical protein 0.0037 0.0027 0.0027
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0619 0.2243 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0194 0.0194
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0054 0.0092 0.0092
Onchocerca volvulus 0.0136 0.0403 0.1369
Brugia malayi Integrin beta pat-3 precursor 0.2504 0.9412 0.9412
Brugia malayi hypothetical protein 0.0073 0.0164 0.0164
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0111 0.0202
Echinococcus granulosus integrin beta 2 0.1855 0.6943 1
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0054 0.0092 0.0092
Echinococcus granulosus allatostatin A receptor 0.0136 0.0403 0.058
Schistosoma mansoni twik family of potassium channels-related 0.0054 0.0092 0.0167
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Onchocerca volvulus 0.0054 0.0092 0.0312
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1057 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0136 0.0405 0.0738
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0136 0.0403 0.058
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0037 0.0027 0.0039
Brugia malayi putative neuropeptide receptor 0.0136 0.0403 0.0403
Onchocerca volvulus 0.0136 0.0403 0.1369
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0037 0.0027 0.0049
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0059 0.011 0.0192
Brugia malayi jmjC domain containing protein 0.0059 0.0111 0.0111
Loa Loa (eye worm) IMP dehydrogenase 1 0.0619 0.2243 0.2243
Giardia lamblia High cysteine protein 0.0081 0.0194 1
Plasmodium vivax hypothetical protein, conserved 0.0136 0.0405 0.1835
Toxoplasma gondii ion channel protein 0.0054 0.0092 0.0305
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0619 0.2243 1
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0696 0.626
Echinococcus granulosus neuropeptide receptor 0.0136 0.0403 0.058
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0655 0.5831
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.0403 0.058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.0403 0.0733
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0027 0.0039
Brugia malayi AKH receptor 0.0136 0.0403 0.0403
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0136 0.0405 0.0738
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0136 0.0403 0.0403
Echinococcus granulosus 7tm_1 domain containing protein 0.0136 0.0403 0.058
Echinococcus granulosus 7TM GPCR rhodopsin 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Echinococcus granulosus neuropeptides capa receptor 0.0136 0.0403 0.058
Onchocerca volvulus 0.0136 0.0403 0.1369
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Leishmania major hypothetical protein, conserved 0.0054 0.0092 0.0293
Onchocerca volvulus 0.0136 0.0403 0.1369
Trypanosoma brucei calcium-activated potassium channel, putative 0.0054 0.0092 0.0293
Brugia malayi Dopamine receptor protein 2 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0054 0.0092 0.0293
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0054 0.0092 0.0293
Onchocerca volvulus 0.0036 0.0024 0.0082
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0054 0.0092 0.0293
Echinococcus granulosus twik family of potassium channels 0.0054 0.0092 0.0132
Toxoplasma gondii hypothetical protein 0.0136 0.0405 0.1719
Schistosoma mansoni twik family of potassium channels-related 0.0054 0.0092 0.0167
Schistosoma mansoni sodium/chloride dependent transporter 0.0136 0.0405 0.0738
Schistosoma mansoni neuropeptide f receptor 76f 0.0136 0.0403 0.0733
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0136 0.0405 0.0738
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0054 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0149 0.0454 0.0454
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0054 0.0092 0.0092
Echinococcus granulosus serotonin transporter 0.0803 0.2941 0.4237
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0162 0.0295
Echinococcus multilocularis serotonin receptor 0.0136 0.0403 0.058
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0619 0.2243 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0803 0.2941 0.2941
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0136 0.0405 0.0584
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0111 0.016
Giardia lamblia High cysteine protein 0.0081 0.0194 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0136 0.0403 0.0403
Leishmania major ion transport protein-like protein 0.0054 0.0092 0.0293
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0019 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.0403 0.058
Brugia malayi Serotonin receptor 0.0136 0.0403 0.0403
Onchocerca volvulus 0.0136 0.0403 0.1369
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0803 0.2941 0.5352
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Toxoplasma gondii hypothetical protein 0.0081 0.0194 0.0765
Echinococcus granulosus H:Cl exchange transporter 4 0.0037 0.0027 0.0039
Loa Loa (eye worm) chloride channel 3 0.0037 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0267 0.0903 0.0903
Schistosoma mansoni voltage-gated potassium channel 0.004 0.004 0.0072
Giardia lamblia Neurogenic locus notch-like protein 0.0081 0.0194 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0111 0.0202
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0583 0.2103 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0136 0.0403 0.0733
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0027 0.0039
Loa Loa (eye worm) hypothetical protein 0.2659 1 1
Echinococcus multilocularis allatostatin A receptor 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0136 0.0403 0.0733
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0619 0.2243 0.4081
Loa Loa (eye worm) hypothetical protein 0.0136 0.0405 0.0405
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0136 0.0405 0.0584
Leishmania major guanosine monophosphate reductase 0.0619 0.2243 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0136 0.0403 0.0733
Echinococcus multilocularis neuropeptide Y receptor 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0054 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0136 0.0403 0.0733
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0136 0.0403 0.058
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0136 0.0403 0.058
Plasmodium vivax potassium channel, putative 0.0054 0.0092 0.0326
Echinococcus granulosus serotonin receptor 0.0136 0.0403 0.058
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0257 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0655 0.5831
Schistosoma mansoni chloride channel protein 0.0037 0.0027 0.0049
Loa Loa (eye worm) hypothetical protein 0.1227 0.4555 0.4555
Loa Loa (eye worm) serotonin transporter b 0.0803 0.2941 0.2941
Loa Loa (eye worm) hypothetical protein 0.0218 0.0717 0.0717
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0162 0.061
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1057 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0136 0.0405 0.0405
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0136 0.0403 0.1369
Schistosoma mansoni sodium-dependent amino acid transporter 0.0136 0.0405 0.0738
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0136 0.0403 0.0403
Onchocerca volvulus 0.0286 0.0975 0.3316
Trypanosoma cruzi GMP reductase 0.0619 0.2243 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Onchocerca volvulus 0.0054 0.0092 0.0312
Echinococcus multilocularis g-protein coupled receptor 0.0136 0.0403 0.058
Schistosoma mansoni amine GPCR 0.0136 0.0403 0.0733
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0149 0.0149
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0136 0.0405 0.0405
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0054 0.0092 0.0092
Schistosoma mansoni protein kinase subunit gamma 0.0037 0.0027 0.0049
Echinococcus granulosus neuropeptide s receptor 0.0684 0.2487 0.3582
Schistosoma mansoni chloride channel protein 0.0037 0.0027 0.0049
Schistosoma mansoni biogenic amine receptor 0.0136 0.0403 0.0733
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0136 0.0403 0.058
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0054 0.0092 0.0092
Schistosoma mansoni calcium-activated potassium channel 0.1227 0.4555 0.8289
Onchocerca volvulus 0.0136 0.0403 0.1369
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0054 0.0092 0.0092
Echinococcus multilocularis G protein coupled receptor 139 0.0136 0.0403 0.058
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0054 0.0092 0.0092
Echinococcus multilocularis neuropeptide receptor 0.0136 0.0403 0.058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0162 0.061
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0136 0.0403 0.0733
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0136 0.0403 0.0403
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.0403 0.058
Brugia malayi G-protein coupled receptor 0.0136 0.0403 0.0403
Loa Loa (eye worm) neuropeptide F receptor 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0059 0.011 0.0192
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0803 0.2941 0.2941
Echinococcus multilocularis neuropeptide receptor 0.0136 0.0403 0.058
Loa Loa (eye worm) melatonin receptor type 1A 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0403
Trypanosoma cruzi ion transport protein, putative 0.0054 0.0092 0.0293
Schistosoma mansoni survival motor neuron protein 0.0048 0.0071 0.0128
Schistosoma mansoni opsin-like receptor 0.0136 0.0403 0.0733
Trypanosoma brucei GMP reductase 0.0619 0.2243 1
Loa Loa (eye worm) GMP reductase 0.0257 0.0866 0.0866
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.012 0.0218
Echinococcus multilocularis g protein coupled receptor 0.0136 0.0403 0.058
Echinococcus granulosus H:Cl exchange transporter 3 0.0037 0.0027 0.0039
Giardia lamblia Tenascin-X 0.0081 0.0194 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0136 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Brugia malayi sulfakinin receptor protein 0.2659 1 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.4 nM Inhibition of 5-HT reuptake (SERT) in rat brain synaptosomes. ChEMBL. 12361398
Ki (binding) = 1.82 nM Selectivity of the compound for norepinephrine transporter ChEMBL. 12361398
Ki (binding) = 23.5 nM Selectivity of the compound for Dopamine transporter ChEMBL. 12361398

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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