Detailed information for compound 950003

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 245.105 | Formula: C10H10Cl2N2O
  • H donors: 1 H acceptors: 2 LogP: 2.25 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc2c(cc1Cl)nc(n2C)C(O)C
  • InChi: 1S/C10H10Cl2N2O/c1-5(15)10-13-8-3-6(11)7(12)4-9(8)14(10)2/h3-5,15H,1-2H3
  • InChiKey: FXDXVQPKKQXEHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) doublecortin family protein 0.00201093 0.00703856 0.0195528
Giardia lamblia High cysteine protein 0.00928125 0.0767465 1
Echinococcus granulosus tm gpcr rhodopsin 0.00145452 0.00170369 0.00170369
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus neuropeptides capa receptor 0.00145452 0.00170369 0.00170369
Schistosoma mansoni amine GPCR 0.00145452 0.00170369 0.00180538
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.00216398 0.00850605 0.250548
Echinococcus granulosus G protein coupled receptor 139 0.00145452 0.00170369 0.00170369
Leishmania major p450 reductase, putative 0.00216398 0.00850605 0.0366671
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.00287493 0.0153226 0.0758952
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0196228 0.175901 0.580548
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.00183716 0.00537248 0.0140103
Echinococcus multilocularis neuropeptide receptor 0.00145452 0.00170369 0.00564584
Onchocerca volvulus 0.00415175 0.0275648 0.0861874
Echinococcus granulosus tm gpcr rhodopsin 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis neuropeptides capa receptor 0.00145452 0.00170369 0.00564584
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni hypothetical protein 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.00216398 0.00850605 0.250548
Onchocerca volvulus 0.00415175 0.0275648 0.0861874
Mycobacterium tuberculosis Probable oxidoreductase 0.00415175 0.0275648 0.0977267
Onchocerca volvulus Putative organic anion transporter 0.00284374 0.0150235 0.0443911
Echinococcus multilocularis Solute carrier organic anion transporter family 0.00284374 0.0150235 0.0497863
Schistosoma mansoni myosin xvIII 0.00145452 0.00170369 0.00180538
Brugia malayi flavodoxin family protein 0.00216398 0.00850605 0.0244347
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Trichomonas vaginalis sulfite reductase, putative 0.00216398 0.00850605 0.0699128
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.00351913 0.0214992 0.0676587
Trypanosoma cruzi aldo/keto reductase, putative 0.00415175 0.0275648 0.146347
Echinococcus multilocularis G-protein coupled receptor, putative 0.00145452 0.00170369 0.00564584
Brugia malayi neuropeptide F receptor 0.00145452 0.00170369 0.00180538
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Echinococcus granulosus sex peptide receptor 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis neuropeptides capa receptor 0.00145452 0.00170369 0.00564584
Echinococcus multilocularis rhodopsin orphan GPCR 0.00145452 0.00170369 0.00564584
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00145452 0.00170369 0.00564584
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00145452 0.00170369 0.00180538
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00145452 0.00170369 0.00180538
Echinococcus granulosus Solute carrier organic anion transporter family 0.00284374 0.0150235 0.0150235
Loa Loa (eye worm) hypothetical protein 0.00284374 0.0150235 0.0461163
Entamoeba histolytica alcohol dehydrogenase, putative 0.00287493 0.0153226 0.518596
Echinococcus granulosus allatostatin A receptor 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis fatty acid binding protein FABP2 0.00351913 0.0214992 0.0712458
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus protein jagged 1 0.00928125 0.0767465 0.0767465
Entamoeba histolytica aldose reductase, putative 0.00415175 0.0275648 1
Brugia malayi lactoylglutathione lyase 0.0196228 0.175901 0.581305
Onchocerca volvulus 0.0327495 0.301761 1
Brugia malayi ABC transporter transmembrane region family protein 0.00149945 0.00213454 0.00323867
Brugia malayi G-protein coupled receptor 0.00145452 0.00170369 0.00180538
Brugia malayi Serotonin receptor 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Brugia malayi Animal haem peroxidase family protein 0.0327495 0.301761 1
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Echinococcus granulosus aldo keto reductase 0.00415175 0.0275648 0.0275648
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.00284374 0.0150235 0.0497863
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Mycobacterium ulcerans hypothetical protein 0.00454081 0.0312951 0.172531
Brugia malayi Dopamine receptor protein 1 0.00145452 0.00170369 0.00180538
Brugia malayi dehydrogenases, short chain protein 2 0.00330361 0.0194328 0.0607846
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00183716 0.00537248 0.0140103
Schistosoma mansoni alpha-1 adrenergic receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Brugia malayi Doublecortin family protein 0.00201093 0.00703856 0.0195528
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Brugia malayi sodium-independent organic anion transporter family protein 0.00284374 0.0150235 0.0461163
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0196228 0.175901 1
Loa Loa (eye worm) TYRA-2 protein 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00145452 0.00170369 0.00564584
Toxoplasma gondii protease inhibitor PI2 0.00183716 0.00537248 0.0186339
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00145452 0.00170369 0.00170369
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Entamoeba histolytica aldose reductase, putative 0.00415175 0.0275648 1
Brugia malayi Delta serrate ligand family protein 0.00928125 0.0767465 0.251449
Brugia malayi FAD binding domain containing protein 0.00216398 0.00850605 0.0244347
Echinococcus granulosus notch 0.00928125 0.0767465 0.0767465
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.00287493 0.0153226 0.0758952
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni histamine h1 receptor 0.00145452 0.00170369 0.00180538
Echinococcus granulosus neurogenic locus protein delta 0.00928125 0.0767465 0.0767465
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.00454081 0.0312951 0.100246
Schistosoma mansoni fatty acid binding protein 0.00351913 0.0214992 0.0676587
Echinococcus multilocularis g protein coupled receptor 0.00145452 0.00170369 0.00564584
Onchocerca volvulus 0.00415175 0.0275648 0.0861874
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Echinococcus granulosus hypothetical protein 0.00415175 0.0275648 0.0275648
Onchocerca volvulus 0.00330361 0.0194328 0.0590859
Echinococcus granulosus g-protein coupled receptor 0.00145452 0.00170369 0.00170369
Schistosoma mansoni notch 0.00928125 0.0767465 0.251449
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048606 0.0343613 0.113869
Echinococcus multilocularis multidrug resistance associated protein 7 0.00149945 0.00213454 0.00707361
Brugia malayi Blistered cuticle protein 3 0.0327495 0.301761 1
Schistosoma mansoni peroxidasin 0.0327495 0.301761 1
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Echinococcus granulosus neurogenic locus notch protein 0.00928125 0.0767465 0.0767465
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.00330361 0.0194328 0.0827243
Onchocerca volvulus 0.00928125 0.0767465 0.250095
Echinococcus multilocularis aldo keto reductase 0.00415175 0.0275648 0.0913466
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus protein jagged 2 0.00928125 0.0767465 0.0767465
Brugia malayi Peroxidasin 0.0327495 0.301761 1
Schistosoma mansoni cell polarity protein 0.00928125 0.0767465 0.251449
Brugia malayi Dopamine receptor protein 2 0.00145452 0.00170369 0.00180538
Mycobacterium ulcerans hypothetical protein 0.00454081 0.0312951 0.172531
Echinococcus granulosus fibropellin Ia 0.00928125 0.0767465 0.0767465
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Schistosoma mansoni lipoxygenase 0.00775525 0.0621152 0.202775
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00145452 0.00170369 0.00564584
Brugia malayi sodium-independent organic anion transporter family protein 0.00284374 0.0150235 0.0461163
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.00287493 0.0153226 0.0504384
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00145452 0.00170369 0.00180538
Onchocerca volvulus Chorion peroxidase homolog 0.0327495 0.301761 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00145452 0.00170369 0.00564584
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Brugia malayi Animal haem peroxidase family protein 0.0327495 0.301761 1
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.00415175 0.0275648 0.847758
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.00454081 0.0312951 0.172531
Echinococcus multilocularis serotonin receptor 0.00145452 0.00170369 0.00564584
Brugia malayi EGF-like domain containing protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Giardia lamblia MRP-like ABC transporter 0.00149945 0.00213454 0.00073493
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Loa Loa (eye worm) hypothetical protein 0.00216398 0.00850605 0.0244347
Trypanosoma brucei prostaglandin f synthase 0.00415175 0.0275648 1
Plasmodium falciparum nitric oxide synthase, putative 0.00216398 0.00850605 0.0086904
Brugia malayi EGF-like domain containing protein 0.00928125 0.0767465 0.251449
Plasmodium falciparum aldo-keto reductase, putative 0.00287493 0.0153226 0.0490577
Schistosoma mansoni notch 0.00928125 0.0767465 0.251449
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Mycobacterium ulcerans oxidoreductase 0.00415175 0.0275648 0.14429
Brugia malayi Serotonin receptor 0.00145452 0.00170369 0.00180538
Brugia malayi Animal haem peroxidase family protein 0.0327495 0.301761 1
Echinococcus granulosus g protein coupled receptor 0.00145452 0.00170369 0.00170369
Echinococcus granulosus organic anion transporting polypeptide 30B 0.00284374 0.0150235 0.0150235
Plasmodium falciparum glyoxalase I 0.0196228 0.175901 1
Echinococcus granulosus serotonin receptor 0.00145452 0.00170369 0.00170369
Brugia malayi Dopamine receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus Solute carrier family 22 5 0.105574 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.00201093 0.00703856 0.00703856
Mycobacterium tuberculosis Conserved protein TB27.3 0.00454081 0.0312951 0.127504
Onchocerca volvulus 0.00201093 0.00703856 0.0177795
Schistosoma mansoni neuropeptide f receptor 76f 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis rhodopsin orphan GPCR 0.00145452 0.00170369 0.00564584
Echinococcus multilocularis protein jagged 1 0.00928125 0.0767465 0.254329
Brugia malayi ORL1-like opioid receptor 0.00145452 0.00170369 0.00180538
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.00216398 0.00850605 0.00850605
Echinococcus multilocularis insulin receptor 0.0048606 0.0343613 0.113869
Brugia malayi GnHR receptor homolog 0.00145452 0.00170369 0.00180538
Schistosoma mansoni rab6-interacting 0.00201093 0.00703856 0.0195528
Schistosoma mansoni amine GPCR 0.00145452 0.00170369 0.00180538
Brugia malayi sodium-independent organic anion transporter family protein 0.00284374 0.0150235 0.0461163
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00145452 0.00170369 0.00180538
Echinococcus granulosus aldo keto reductase family 1, member B4 0.00287493 0.0153226 0.0153226
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.00817272 0.0661179 0.0661179
Echinococcus multilocularis epidermal growth factor receptor 0.015211 0.133601 0.442737
Brugia malayi Muscle positioning protein 4 0.00928125 0.0767465 0.251449
Schistosoma mansoni notch 0.00928125 0.0767465 0.251449
Echinococcus granulosus fmrfamide receptor 0.00145452 0.00170369 0.00170369
Schistosoma mansoni multidrug resistance protein 0.00149945 0.00213454 0.00323867
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00145452 0.00170369 0.00564584
Echinococcus granulosus insulin receptor 0.0048606 0.0343613 0.0343613
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Brugia malayi EGF-like domain containing protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni biogenic amine receptor 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis neuropeptide receptor A26 0.00145452 0.00170369 0.00564584
Echinococcus multilocularis sex peptide receptor 0.00145452 0.00170369 0.00564584
Brugia malayi putative neuropeptide receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Schistosoma mansoni neuropeptide F-like receptor 0.00145452 0.00170369 0.00180538
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni aldo-keto reductase 0.00415175 0.0275648 0.0878372
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.00183716 0.00537248 0.0140103
Echinococcus multilocularis neurogenic locus protein delta 0.00928125 0.0767465 0.254329
Onchocerca volvulus Peroxidasin homolog 0.0327495 0.301761 1
Brugia malayi SPARC precursor 0.00183716 0.00537248 0.0140103
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.00216398 0.00850605 0.0281881
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Brugia malayi hypothetical protein 0.00201093 0.00703856 0.0195528
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00145452 0.00170369 0.00180538
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.00415175 0.0275648 0.847758
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus protein jagged 2 0.00928125 0.0767465 0.0767465
Echinococcus granulosus orexin receptor type 2 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Toxoplasma gondii EGF family domain-containing protein 0.00928125 0.0767465 0.42938
Schistosoma mansoni tyrosine kinase 0.0048606 0.0343613 0.110447
Onchocerca volvulus 0.00928125 0.0767465 0.250095
Loa Loa (eye worm) hypothetical protein 0.00314538 0.0179157 0.0557375
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00145452 0.00170369 0.00180538
Chlamydia trachomatis sulfite reductase 0.00139792 0.00116099 0.5
Schistosoma mansoni potassium channel beta 0.00287493 0.0153226 0.0471111
Schistosoma mansoni hypothetical protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis rhodopsin orphan GPCR 0.00145452 0.00170369 0.00564584
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.00415175 0.0275648 0.880804
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Onchocerca volvulus 0.00330361 0.0194328 0.0590859
Mycobacterium tuberculosis Conserved protein 0.00454081 0.0312951 0.127504
Echinococcus multilocularis rhodopsin orphan GPCR 0.00145452 0.00170369 0.00564584
Trichomonas vaginalis conserved hypothetical protein 0.00454081 0.0312951 1
Echinococcus multilocularis epidermal growth factor receptor 0.00817272 0.0661179 0.219107
Echinococcus granulosus follistatin 0.00183716 0.00537248 0.00537248
Echinococcus multilocularis 0.00470813 0.0328994 0.109025
Schistosoma mansoni adenoreceptor 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis protein jagged 1 0.00928125 0.0767465 0.254329
Echinococcus multilocularis fat cadherin tumor suppressor 0.00928125 0.0767465 0.254329
Onchocerca volvulus 0.00330361 0.0194328 0.0590859
Schistosoma mansoni hypothetical protein 0.00928125 0.0767465 0.251449
Giardia lamblia Aldose reductase 0.00415175 0.0275648 0.341318
Brugia malayi hypothetical protein 0.00284374 0.0150235 0.0461163
Mycobacterium ulcerans glyoxalase GloA 0.00454081 0.0312951 0.172531
Entamoeba histolytica alcohol dehydrogenase, putative 0.00287493 0.0153226 0.518596
Echinococcus granulosus neurogenic locus notch protein 4 0.00928125 0.0767465 0.0767465
Toxoplasma gondii glyoxalase I, putative 0.0196228 0.175901 1
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni notch 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.00330361 0.0194328 0.099549
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.00928125 0.0767465 0.251449
Echinococcus multilocularis slit 2 protein 0.00928125 0.0767465 0.254329
Loa Loa (eye worm) hypothetical protein 0.00284374 0.0150235 0.0461163
Loa Loa (eye worm) blistered cuticle protein 3 0.0327495 0.301761 1
Onchocerca volvulus Putative organic anion transporter 0.00284374 0.0150235 0.0443911
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.00415175 0.0275648 0.847758
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Giardia lamblia Nitric oxide synthase, inducible 0.00198532 0.00679304 0.0631255
Loa Loa (eye worm) hypothetical protein 0.00149373 0.00207966 0.00305611
Loa Loa (eye worm) oxidoreductase 0.00415175 0.0275648 0.0878372
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.00216398 0.00850605 0.250548
Echinococcus granulosus epidermal growth factor receptor 0.00817272 0.0661179 0.0661179
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00145452 0.00170369 0.00564584
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.00454081 0.0312951 0.100246
Echinococcus granulosus voltage gated potassium channel subunit 0.00287493 0.0153226 0.0153226
Leishmania major aldo-keto reductase-like protein 0.00415175 0.0275648 0.146347
Onchocerca volvulus 0.00928125 0.0767465 0.250095
Echinococcus granulosus neuropeptide Y receptor 0.00145452 0.00170369 0.00170369
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00145452 0.00170369 0.00180538
Echinococcus granulosus g protein coupled receptor 0.00145452 0.00170369 0.00170369
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.00183716 0.00537248 0.0140103
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00145452 0.00170369 0.00564584
Echinococcus granulosus 7TM GPCR rhodopsin 0.00145452 0.00170369 0.00170369
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Echinococcus multilocularis aldo keto reductase 0.00415175 0.0275648 0.0913466
Toxoplasma gondii transporter, major facilitator family protein 0.00284374 0.0150235 0.0741743
Mycobacterium ulcerans epoxide hydrolase EphA 0.0159402 0.140593 1
Schistosoma mansoni hypothetical protein 0.00201093 0.00703856 0.0195528
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Onchocerca volvulus 0.00928125 0.0767465 0.250095
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus tm gpcr rhodopsin 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis g protein coupled receptor 0.00145452 0.00170369 0.00564584
Onchocerca volvulus 0.0327495 0.301761 1
Echinococcus multilocularis fibropellin Ia 0.00928125 0.0767465 0.254329
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Echinococcus granulosus dro:myosuppressin receptor 0.00145452 0.00170369 0.00170369
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.00351913 0.0214992 0.0676587
Echinococcus multilocularis G protein coupled receptor 139 0.00145452 0.00170369 0.00564584
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00145452 0.00170369 0.00180538
Brugia malayi G-protein coupled receptor 0.00145452 0.00170369 0.00180538
Schistosoma mansoni aldo-keto reductase 0.00415175 0.0275648 0.0878372
Schistosoma mansoni biogenic amine (5HT) receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) animal heme peroxidase 0.0327495 0.301761 1
Loa Loa (eye worm) neuropeptide F receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00314538 0.0179157 0.0557375
Brugia malayi RE15519p 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00183716 0.00537248 0.0140103
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) sodium-independent organic anion transporter 0.00284374 0.0150235 0.0461163
Echinococcus granulosus alpha 1A adrenergic receptor 0.00145452 0.00170369 0.00170369
Loa Loa (eye worm) hypothetical protein 0.00284374 0.0150235 0.0461163
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Schistosoma mansoni laminin gamma-3 chain 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.00149945 0.00213454 0.00323867
Schistosoma mansoni septate junction protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni tyrosine kinase 0.0048606 0.0343613 0.110447
Brugia malayi Animal haem peroxidase family protein 0.0327495 0.301761 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni lipoxygenase 0.0113749 0.0968206 0.318229
Loa Loa (eye worm) hypothetical protein 0.00284374 0.0150235 0.0461163
Brugia malayi G protein-coupled receptor F59B2.13 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) FAD binding domain-containing protein 0.00216398 0.00850605 0.0244347
Loa Loa (eye worm) oxidoreductase 0.00330361 0.0194328 0.0607846
Schistosoma mansoni hypothetical protein 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Mycobacterium leprae Possible oxidoreductase 0.00287493 0.0153226 0.489617
Brugia malayi hypothetical protein 0.00284374 0.0150235 0.0461163
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0113749 0.0968206 0.0968206
Echinococcus granulosus neuropeptide Y receptor 0.00145452 0.00170369 0.00170369
Echinococcus granulosus hypothetical protein 0.00145452 0.00170369 0.00170369
Loa Loa (eye worm) hypothetical protein 0.00183716 0.00537248 0.0140103
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00145452 0.00170369 0.00564584
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Onchocerca volvulus 0.00183716 0.00537248 0.012227
Onchocerca volvulus Peroxidasin homolog 0.0327495 0.301761 1
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Giardia lamblia Hypothetical protein 0.00198532 0.00679304 0.0631255
Loa Loa (eye worm) animal heme peroxidase 0.0327495 0.301761 1
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis fmrfamide receptor 0.00145452 0.00170369 0.00564584
Trypanosoma cruzi aldo-keto reductase 0.00415175 0.0275648 0.146347
Brugia malayi hypothetical protein 0.0327495 0.301761 1
Loa Loa (eye worm) hypothetical protein 0.00149945 0.00213454 0.00323867
Echinococcus multilocularis neurogenic locus protein delta 0.00928125 0.0767465 0.254329
Trypanosoma cruzi aldo/keto reductase, putative 0.00287493 0.0153226 0.0758952
Echinococcus multilocularis lipoxygenase domain containing protein 0.00201093 0.00703856 0.023325
Brugia malayi Melatonin receptor type 1A 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis multidrug resistance associated protein 1 0.00149945 0.00213454 0.00707361
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00145452 0.00170369 0.00564584
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni cytochrome P450 reductase 0.00216398 0.00850605 0.0244347
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Onchocerca volvulus 0.00287493 0.0153226 0.0453877
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.00183716 0.00537248 0.0140103
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Schistosoma mansoni hypothetical protein 0.00928125 0.0767465 0.251449
Echinococcus multilocularis neuropeptide FF receptor 2 0.00145452 0.00170369 0.00564584
Echinococcus granulosus neuropeptide receptor A26 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00145452 0.00170369 0.00564584
Onchocerca volvulus Putative cubilin 0.00928125 0.0767465 0.250095
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0113749 0.0968206 0.320852
Loa Loa (eye worm) animal heme peroxidase 0.0327495 0.301761 1
Brugia malayi Animal haem peroxidase family protein 0.0327495 0.301761 1
Onchocerca volvulus 0.00415175 0.0275648 0.0861874
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Echinococcus granulosus rhodopsin orphan GPCR 0.00145452 0.00170369 0.00170369
Brugia malayi hypothetical protein 0.00330361 0.0194328 0.0607846
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.00415175 0.0275648 0.146347
Loa Loa (eye worm) hypothetical protein 0.0196228 0.175901 0.581305
Trichomonas vaginalis aldo/keto reductase, putative 0.00415175 0.0275648 0.847758
Echinococcus granulosus peroxidasin 0.0327495 0.301761 0.301761
Loa Loa (eye worm) oxidoreductase 0.00415175 0.0275648 0.0878372
Schistosoma mansoni hypothetical protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni polycystin 1-related 0.00201093 0.00703856 0.0195528
Echinococcus granulosus rhodopsin orphan GPCR 0.00145452 0.00170369 0.00170369
Trichomonas vaginalis aldo-keto reductase, putative 0.00287493 0.0153226 0.348116
Onchocerca volvulus 0.00284374 0.0150235 0.0443911
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.00415175 0.0275648 0.146347
Echinococcus granulosus rhodopsin orphan GPCR 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00145452 0.00170369 0.00564584
Echinococcus multilocularis somatostatin receptor 0.00145452 0.00170369 0.00564584
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni opsin-like receptor 0.00145452 0.00170369 0.00180538
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.00183716 0.00537248 0.0186339
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) G-protein coupled receptor 0.00145452 0.00170369 0.00180538
Brugia malayi putative neuropeptide receptor NPR1 0.00145452 0.00170369 0.00180538
Schistosoma mansoni opsin-like receptor 0.00145452 0.00170369 0.00180538
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.00928125 0.0767465 0.251449
Schistosoma mansoni tyrosine kinase 0.00808649 0.0652912 0.213341
Echinococcus multilocularis orexin receptor type 2 0.00145452 0.00170369 0.00564584
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.00183716 0.00537248 0.0140103
Schistosoma mansoni hypothetical protein 0.00145452 0.00170369 0.00180538
Brugia malayi Calcium binding EGF domain containing protein 0.00928125 0.0767465 0.251449
Echinococcus granulosus neural cadherin 0.00928125 0.0767465 0.0767465
Echinococcus granulosus peptide allatostatin:somatostatin 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis neurogenic locus notch protein 0.00928125 0.0767465 0.254329
Echinococcus multilocularis neuropeptide Y receptor 0.00145452 0.00170369 0.00564584
Loa Loa (eye worm) hypothetical protein 0.00314538 0.0179157 0.0557375
Mycobacterium ulcerans hypothetical protein 0.00454081 0.0312951 0.172531
Schistosoma mansoni amine GPCR 0.00145452 0.00170369 0.00180538
Echinococcus granulosus epidermal growth factor receptor 0.015211 0.133601 0.133601
Loa Loa (eye worm) TK/EGFR protein kinase 0.015211 0.133601 0.440585
Loa Loa (eye worm) hypothetical protein 0.00284374 0.0150235 0.0461163
Schistosoma mansoni hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni slit 0.00928125 0.0767465 0.251449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus tachykinin peptides receptor 99D 0.00145452 0.00170369 0.00170369
Echinococcus granulosus fatty acid binding protein FABP2 0.00351913 0.0214992 0.0214992
Brugia malayi Protein kinase domain containing protein 0.0048606 0.0343613 0.110447
Brugia malayi G protein-coupled receptor 0.00145452 0.00170369 0.00180538
Schistosoma mansoni loxhd1 0.00201093 0.00703856 0.0195528
Echinococcus multilocularis serotonin receptor 0.00145452 0.00170369 0.00564584
Brugia malayi Tachykinin-like peptides receptor 99D 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Trypanosoma brucei aldo-keto reductase, putative 0.00415175 0.0275648 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00145452 0.00170369 0.00564584
Mycobacterium ulcerans hypothetical protein 0.00287493 0.0153226 0.0516065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Loa Loa (eye worm) hypothetical protein 0.00284374 0.0150235 0.0461163
Schistosoma mansoni opsin-like receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis aldo keto reductase 0.00415175 0.0275648 0.0913466
Mycobacterium ulcerans glyoxalase GloA 0.00454081 0.0312951 0.172531
Schistosoma mansoni hypothetical protein 0.00928125 0.0767465 0.251449
Echinococcus granulosus fatty acid binding protein FABP2 0.00351913 0.0214992 0.0214992
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.00216398 0.00850605 0.0281881
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.00216398 0.00850605 0.0366671
Schistosoma mansoni peroxidasin 0.0327495 0.301761 1
Brugia malayi larval opioid receptor 0.00145452 0.00170369 0.00180538
Schistosoma mansoni multidrug resistance protein 0.00149945 0.00213454 0.00323867
Echinococcus multilocularis RUN 0.00201093 0.00703856 0.023325
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.00454081 0.0312951 0.127504
Mycobacterium tuberculosis Conserved protein 0.00454081 0.0312951 0.127504
Trichomonas vaginalis aldo-keto reductase, putative 0.00287493 0.0153226 0.348116
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00145452 0.00170369 0.00180538
Trypanosoma cruzi cytochrome P450 reductase, putative 0.00216398 0.00850605 0.0366671
Loa Loa (eye worm) neuropeptide F receptor 0.00145452 0.00170369 0.00180538
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00145452 0.00170369 0.00180538
Onchocerca volvulus 0.00201093 0.00703856 0.0177795
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00145452 0.00170369 0.00564584
Brugia malayi sulfakinin receptor protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.00454081 0.0312951 0.100246
Echinococcus granulosus multidrug resistance associated protein 7 0.00149945 0.00213454 0.00213454
Plasmodium vivax glyoxalase I, putative 0.00454081 0.0312951 0.14489
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni amine GPCR 0.00145452 0.00170369 0.00180538
Echinococcus granulosus protein jagged 1 0.00928125 0.0767465 0.0767465
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Echinococcus multilocularis aldo keto reductase 0.00415175 0.0275648 0.0913466
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.00287493 0.0153226 0.0471111
Echinococcus granulosus rhodopsin orphan GPCR 0.00145452 0.00170369 0.00170369
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.00415175 0.0275648 0.0878372
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00145452 0.00170369 0.00180538
Trichomonas vaginalis conserved hypothetical protein 0.00454081 0.0312951 1
Brugia malayi secreted modular calcium-binding protein 1 0.00183716 0.00537248 0.0140103
Echinococcus multilocularis peroxidasin 0.0327495 0.301761 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0048606 0.0343613 0.110447
Schistosoma mansoni organic anion transporter 0.00284374 0.0150235 0.0461163
Echinococcus multilocularis fmrfamide receptor 0.00145452 0.00170369 0.00564584
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Brugia malayi EGF-like domain containing protein 0.00928125 0.0767465 0.251449
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) oxidoreductase 0.00415175 0.0275648 0.0878372
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Schistosoma mansoni amine GPCR 0.00145452 0.00170369 0.00180538
Echinococcus granulosus neuropeptide receptor 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis Polycystic kidney disease protein 0.00201093 0.00703856 0.023325
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Onchocerca volvulus Putative protein 0.00454081 0.0312951 0.0986192
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00145452 0.00170369 0.00564584
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.00330361 0.0194328 0.0607846
Onchocerca volvulus Slit protein homolog 0.00928125 0.0767465 0.250095
Echinococcus multilocularis neuropeptide receptor 0.00145452 0.00170369 0.00564584
Trichomonas vaginalis alcohol dehydrogenase, putative 0.00287493 0.0153226 0.348116
Echinococcus multilocularis rhodopsin orphan GPCR 0.00145452 0.00170369 0.00564584
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni neuropeptide receptor 0.00145452 0.00170369 0.00180538
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0196228 0.175901 1
Schistosoma mansoni biogenic amine receptor 0.00145452 0.00170369 0.00180538
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Schistosoma mansoni multidrug resistance protein 0.00149945 0.00213454 0.00323867
Mycobacterium tuberculosis Conserved hypothetical protein 0.00454081 0.0312951 0.127504
Plasmodium vivax aldehyde reductase, putative 0.00287493 0.0153226 0.0504384
Schistosoma mansoni neuropeptide F-like receptor 0.00145452 0.00170369 0.00180538
Schistosoma mansoni biogenic amine receptor 0.00145452 0.00170369 0.00180538
Schistosoma mansoni fatty acid binding protein 0.00351913 0.0214992 0.0676587
Loa Loa (eye worm) Notch2 0.00928125 0.0767465 0.251449
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus rhodopsin orphan GPCR 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis allatostatin A receptor 0.00145452 0.00170369 0.00564584
Onchocerca volvulus 0.00284374 0.0150235 0.0443911
Schistosoma mansoni growth hormone secretagogue receptor 0.00145452 0.00170369 0.00180538
Brugia malayi Cadherin domain containing protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Onchocerca volvulus 0.00415175 0.0275648 0.0861874
Trichomonas vaginalis aldo/keto reductase, putative 0.00415175 0.0275648 0.847758
Echinococcus granulosus g protein coupled receptor 0.00145452 0.00170369 0.00170369
Brugia malayi follicle stimulating hormone receptor 0.00145452 0.00170369 0.00180538
Brugia malayi GCC2 and GCC3 family protein 0.00928125 0.0767465 0.251449
Echinococcus granulosus aldo keto reductase 0.00415175 0.0275648 0.0275648
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) hypothetical protein 0.00201093 0.00703856 0.0195528
Echinococcus granulosus biogenic amine 5HT receptor 0.00145452 0.00170369 0.00170369
Echinococcus granulosus neuropeptide receptor 0.00145452 0.00170369 0.00170369
Echinococcus granulosus somatostatin receptor 0.00145452 0.00170369 0.00170369
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.00415175 0.0275648 0.0878372
Schistosoma mansoni tyrosine kinase 0.00817272 0.0661179 0.216091
Trichomonas vaginalis aldo/keto reductase, putative 0.00415175 0.0275648 0.847758
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0196228 0.175901 1
Mycobacterium ulcerans hypothetical protein 0.00454081 0.0312951 0.172531
Echinococcus granulosus RUN 0.00201093 0.00703856 0.00703856
Echinococcus granulosus delta-like protein 1 0.00928125 0.0767465 0.0767465
Brugia malayi AKH receptor 0.00145452 0.00170369 0.00180538
Onchocerca volvulus Neurogenic locus notch homolog 0.00928125 0.0767465 0.250095
Schistosoma mansoni follistatin 0.00183716 0.00537248 0.0140103
Echinococcus multilocularis neuropeptide Y receptor 0.00145452 0.00170369 0.00564584
Echinococcus multilocularis fatty acid binding protein FABP2 0.00351913 0.0214992 0.0712458
Echinococcus multilocularis neurogenic locus notch protein 0.00928125 0.0767465 0.254329
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048606 0.0343613 0.0343613
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00145452 0.00170369 0.00180538
Onchocerca volvulus Peroxidase homolog 0.0327495 0.301761 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Mycobacterium ulcerans hypothetical protein 0.00454081 0.0312951 0.172531
Trichomonas vaginalis conserved hypothetical protein 0.00287493 0.0153226 0.348116
Echinococcus multilocularis agrin 0.00183716 0.00537248 0.0178038
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus slit 2 protein 0.00928125 0.0767465 0.0767465
Schistosoma mansoni rab6-interacting 0.00201093 0.00703856 0.0195528
Echinococcus multilocularis expressed protein 0.00183716 0.00537248 0.0178038
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) G-protein coupled receptor 0.00145452 0.00170369 0.00180538
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.00216398 0.00850605 0.0101297
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Brugia malayi prostaglandin transporter 0.00284374 0.0150235 0.0461163
Trypanosoma cruzi cytochrome P450 reductase, putative 0.00216398 0.00850605 0.0366671
Trypanosoma cruzi p450 reductase, putative 0.00216398 0.00850605 0.0366671
Plasmodium falciparum aldehyde reductase, putative 0.00287493 0.0153226 0.0490577
Echinococcus granulosus 7tm_1 domain containing protein 0.00145452 0.00170369 0.00170369
Onchocerca volvulus 0.00330361 0.0194328 0.0590859
Schistosoma mansoni neuropeptide receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) oxidoreductase 0.00415175 0.0275648 0.0878372
Echinococcus multilocularis follistatin 0.00183716 0.00537248 0.0178038
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.00287493 0.0153226 0.0758952
Leishmania major prostaglandin f synthase, putative 0.00415175 0.0275648 0.146347
Plasmodium falciparum glyoxalase I 0.00454081 0.0312951 0.143646
Loa Loa (eye worm) notch protein 0.00928125 0.0767465 0.251449
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Loa Loa (eye worm) hypothetical protein 0.00201093 0.00703856 0.0195528
Loa Loa (eye worm) melatonin receptor type 1A 0.00145452 0.00170369 0.00180538
Toxoplasma gondii glyoxalase family protein 0.00454081 0.0312951 0.167814
Brugia malayi glutamate-cysteine ligase modifier subunit 0.00287493 0.0153226 0.0471111
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis voltage gated potassium channel subunit 0.00287493 0.0153226 0.0507772
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Loa Loa (eye worm) hypothetical protein 0.00183716 0.00537248 0.0140103
Schistosoma mansoni tyrosine kinase 0.00808649 0.0652912 0.213341
Schistosoma mansoni tyrosine kinase 0.00808649 0.0652912 0.213341
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00145452 0.00170369 0.00564584
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni gynecophoral canal protein 0.00454081 0.0312951 0.100246
Brugia malayi multidrug resistance related protein 1 0.00149945 0.00213454 0.00323867
Echinococcus granulosus aldo keto reductase 0.00415175 0.0275648 0.0275648
Mycobacterium leprae conserved hypothetical protein 0.00454081 0.0312951 1
Trypanosoma brucei aldo/keto reductase, putative 0.00287493 0.0153226 0.518596
Schistosoma mansoni tyrosine kinase 0.00817272 0.0661179 0.216091
Loa Loa (eye worm) agrin synaptic family protein 0.00183716 0.00537248 0.0140103
Echinococcus multilocularis rhodopsin orphan GPCR 0.00145452 0.00170369 0.00564584
Brugia malayi hypothetical protein 0.00201093 0.00703856 0.0195528
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Onchocerca volvulus Putative organic anion transporter 0.00284374 0.0150235 0.0443911
Echinococcus granulosus agrin 0.00183716 0.00537248 0.00537248
Schistosoma mansoni agrin 0.00183716 0.00537248 0.0140103
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Leishmania major cytochrome P450 reductase, putative 0.00198532 0.00679304 0.026809
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Echinococcus granulosus neuropeptides capa receptor 0.00145452 0.00170369 0.00170369
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00145452 0.00170369 0.00180538
Trypanosoma cruzi MFS transporter, putative 0.00284374 0.0150235 0.0741743
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.00330361 0.0194328 0.0607846
Brugia malayi neuropeptide F receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Schistosoma mansoni pol-related 0.00415175 0.0275648 0.0878372
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0159402 0.140593 1
Schistosoma mansoni neuropeptide receptor 0.00145452 0.00170369 0.00180538
Trichomonas vaginalis aldo-keto reductase, putative 0.00287493 0.0153226 0.348116
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.00216398 0.00850605 0.0366671
Echinococcus multilocularis lipoxygenase domain containing protein 0.00201093 0.00703856 0.023325
Onchocerca volvulus 0.00330361 0.0194328 0.0590859
Onchocerca volvulus 0.00415175 0.0275648 0.0861874
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.00330361 0.0194328 0.0607846
Echinococcus multilocularis dro:myosuppressin receptor 0.00145452 0.00170369 0.00564584
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.00330361 0.0194328 0.0607846
Echinococcus multilocularis notch 0.00928125 0.0767465 0.254329
Brugia malayi EGF-like domain containing protein 0.00928125 0.0767465 0.251449
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.00415175 0.0275648 0.0878372
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Echinococcus granulosus neuropeptide s receptor 0.00145452 0.00170369 0.00170369
Onchocerca volvulus Peroxidase homolog 0.0327495 0.301761 1
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00145452 0.00170369 0.00180538
Echinococcus multilocularis protein jagged 2 0.00928125 0.0767465 0.254329
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Schistosoma mansoni tyrosine kinase 0.015211 0.133601 0.440585
Echinococcus granulosus lipoxygenase domain containing protein 0.00201093 0.00703856 0.00703856
Schistosoma mansoni notch 0.00928125 0.0767465 0.251449
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Toxoplasma gondii aldose reductase, putative 0.00415175 0.0275648 0.146347
Echinococcus multilocularis g protein coupled receptor 0.00145452 0.00170369 0.00564584
Echinococcus granulosus neuropeptide FF receptor 2 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis neurogenic locus notch protein 4 0.00928125 0.0767465 0.254329
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.00183716 0.00537248 0.0186339
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00145452 0.00170369 0.00180538
Schistosoma mansoni organic anion transporter 0.00284374 0.0150235 0.0461163
Echinococcus multilocularis neural cadherin 0.00928125 0.0767465 0.254329
Loa Loa (eye worm) oxidoreductase 0.00415175 0.0275648 0.0878372
Plasmodium vivax multidomain scavenger receptor, putative 0.00201093 0.00703856 0.00145187
Schistosoma mansoni hypothetical protein 0.00145452 0.00170369 0.00180538
Giardia lamblia ABC transporter, putative 0.00149945 0.00213454 0.00073493
Echinococcus multilocularis neuropeptide s receptor 0.00145452 0.00170369 0.00564584
Brugia malayi Calcium binding EGF domain containing protein 0.00928125 0.0767465 0.251449
Brugia malayi NADH-dependent xylose reductase 0.00287493 0.0153226 0.0471111
Plasmodium vivax glyoxalase I, putative 0.0196228 0.175901 1
Giardia lamblia Multidrug resistance-associated protein 1 0.00149945 0.00213454 0.00073493
Brugia malayi Furin-like cysteine rich region family protein 0.015211 0.133601 0.440585
Onchocerca volvulus 0.00928125 0.0767465 0.250095
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Giardia lamblia Multidrug resistance-associated protein 1 0.00149945 0.00213454 0.00073493
Schistosoma mansoni notch 0.00928125 0.0767465 0.251449
Echinococcus granulosus multidrug resistance associated protein 1 0.00149945 0.00213454 0.00213454
Echinococcus granulosus rhodopsin orphan GPCR 0.00145452 0.00170369 0.00170369
Brugia malayi notch-like transmembrane receptor 0.00928125 0.0767465 0.251449
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.00415175 0.0275648 0.0913466
Onchocerca volvulus Dual oxidase homolog 0.0327495 0.301761 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.00415175 0.0275648 0.0878372
Brugia malayi EGF-like domain containing protein 0.00928125 0.0767465 0.251449
Brugia malayi hypothetical protein 0.00145452 0.00170369 0.00180538
Echinococcus granulosus methionine synthase reductase 0.00139792 0.00116099 0.00116099
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00928125 0.0767465 0.251449
Onchocerca volvulus 0.00284374 0.0150235 0.0443911
Loa Loa (eye worm) animal heme peroxidase 0.0327495 0.301761 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00145452 0.00170369 0.00170369
Echinococcus multilocularis methionine synthase reductase 0.00139792 0.00116099 0.0038474
Mycobacterium ulcerans short chain dehydrogenase 0.00330361 0.0194328 0.0827243
Echinococcus multilocularis g-protein coupled receptor 0.00145452 0.00170369 0.00564584
Entamoeba histolytica aldose reductase, putative 0.00415175 0.0275648 1
Onchocerca volvulus 0.00284374 0.0150235 0.0443911
Brugia malayi EGF-like domain containing protein 0.00928125 0.0767465 0.251449
Mycobacterium ulcerans hypothetical protein 0.00454081 0.0312951 0.172531
Loa Loa (eye worm) hypothetical protein 0.00314538 0.0179157 0.0557375
Echinococcus granulosus NADPH cytochrome P450 reductase 0.00216398 0.00850605 0.00850605
Schistosoma mansoni neuropeptide receptor 0.00145452 0.00170369 0.00180538
Echinococcus granulosus neurogenic locus notch protein 0.00928125 0.0767465 0.0767465
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Echinococcus granulosus biogenic amine 5HT receptor 0.00145452 0.00170369 0.00170369
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Brugia malayi Cadherin domain containing protein 0.00928125 0.0767465 0.251449
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00145452 0.00170369 0.00170369
Loa Loa (eye worm) hypothetical protein 0.00149945 0.00213454 0.00323867
Trichomonas vaginalis aldo-keto reductase, putative 0.00415175 0.0275648 0.847758
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00145452 0.00170369 0.00180538
Giardia lamblia Aldose reductase 0.00415175 0.0275648 0.341318
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00145452 0.00170369 0.00170369
Loa Loa (eye worm) hypothetical protein 0.0327495 0.301761 1
Schistosoma mansoni multidrug resistance protein 0.00149945 0.00213454 0.00323867
Schistosoma mansoni hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00415175 0.0275648 0.0878372
Brugia malayi Calcium binding EGF domain containing protein 0.00928125 0.0767465 0.251449
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00145452 0.00170369 0.00170369
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.00216398 0.00850605 0.250548
Onchocerca volvulus 0.00330361 0.0194328 0.0590859
Loa Loa (eye worm) hypothetical protein 0.00284374 0.0150235 0.0461163
Echinococcus granulosus aldo keto reductase family 1 member B4 0.00415175 0.0275648 0.0275648
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) hypothetical protein 0.00145452 0.00170369 0.00180538
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00145452 0.00170369 0.00180538
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.00183716 0.00537248 0.0186339
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00145452 0.00170369 0.00564584
Echinococcus granulosus lipoxygenase domain containing protein 0.00201093 0.00703856 0.00703856
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00145452 0.00170369 0.00170369
Onchocerca volvulus 0.0327495 0.301761 1
Onchocerca volvulus 0.00284374 0.0150235 0.0443911
Toxoplasma gondii aldo-keto reductase 0.00287493 0.0153226 0.0758952
Onchocerca volvulus Neurogenic locus notch protein homolog 0.00928125 0.0767465 0.250095
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.00183716 0.00537248 0.0186339

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.0407 uM Antiprotozoal activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs ChEMBL. 19186059

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trichomonas vaginalis ChEMBL23 19186059

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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