Detailed information for compound 987226

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 490.526 | Formula: C27H27FN4O4
  • H donors: 2 H acceptors: 4 LogP: 2.5 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCc1cccnc1)NCc1ccc(cc1)c1ccc(cc1F)N1C[C@@H](OC1=O)CNC(=O)C
  • InChi: 1S/C27H27FN4O4/c1-18(33)30-16-23-17-32(27(35)36-23)22-9-10-24(25(28)13-22)21-7-4-20(5-8-21)15-31-26(34)11-6-19-3-2-12-29-14-19/h2-5,7-10,12-14,23H,6,11,15-17H2,1H3,(H,30,33)(H,31,34)/t23-/m0/s1
  • InChiKey: SPVYPLKURXLGGV-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0037 0.0037
Giardia lamblia Beta tubulin 0.2796 1 1
Schistosoma mansoni tubulin subunit gamma 0.1713 0.6111 0.6111
Leishmania major beta tubulin 0.2796 1 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.0264 0.0264
Trypanosoma cruzi alpha tubulin, putative 0.2098 0.7493 0.7479
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0028 0.0028
Trichomonas vaginalis tubulin gamma chain, putative 0.2796 1 1
Brugia malayi Cell division protein ftsZ 0.0719 0.2541 0.2541
Trypanosoma brucei tubulin gamma chain 0.1713 0.6111 0.6089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0028 0.0028
Onchocerca volvulus 0.0019 0.0028 0.0033
Leishmania major beta tubulin 0.2796 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Brugia malayi beta-tubulin, identical 0.2796 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0106 0.0106
Brugia malayi nuclear hormone receptor 0.0019 0.0028 0.0028
Plasmodium vivax tubulin alpha chain, putative 0.2098 0.7493 0.6639
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0018 0.0018
Mycobacterium leprae cell division protein FtsZ 0.0719 0.2541 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0097 0.0307 0.0307
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.2098 0.7493 0.7469
Schistosoma mansoni tubulin subunit beta 0.2796 1 1
Plasmodium falciparum alpha tubulin 2 0.2098 0.7493 0.6639
Brugia malayi Protein kinase domain containing protein 0.0018 0.0022 0.0022
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0111 0.0359 0.0305
Loa Loa (eye worm) tubulin beta-1 chain 0.2796 1 1
Trichomonas vaginalis tubulin, putative 0.0849 0.301 0.2945
Brugia malayi tubulin alpha-2 chain 0.2098 0.7493 0.7493
Giardia lamblia Delta tubulin 0.0719 0.2541 0.2263
Leishmania major beta tubulin 0.2796 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.2098 0.7493 0.7493
Echinococcus granulosus mitogen activated protein kinase 3 0.0111 0.0359 0.0359
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1379 0.4911 0.4911
Leishmania major beta tubulin 0.2796 1 1
Leishmania major delta tubulin, putative 0.1612 0.5749 0.5726
Echinococcus granulosus Tubulin alpha 1 chain 0.2098 0.7493 0.7493
Giardia lamblia Epsilon tubulin 0.0861 0.3052 0.2794
Leishmania major beta tubulin 0.2796 1 1
Toxoplasma gondii beta-1 tubulin, putative 0.2796 1 1
Brugia malayi tubulin alpha chain - mouse 0.2098 0.7493 0.7493
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0106 0.0106
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Brugia malayi Muscleblind-like protein 0.0145 0.048 0.048
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0111 0.0359 0.0359
Brugia malayi Tubulin beta chain 0.0719 0.2541 0.2541
Echinococcus granulosus tubulin alpha chain 0.2098 0.7493 0.7493
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0106 0.0294
Plasmodium falciparum alpha tubulin 1 0.2098 0.7493 0.6639
Echinococcus granulosus Tubulin beta 2C chain 0.2796 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.2098 0.7493 0.7493
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Brugia malayi Tubulin alpha chain 0.2098 0.7493 0.7493
Echinococcus granulosus tubulin alpha 1C chain 0.2098 0.7493 0.7493
Echinococcus multilocularis Tubulin beta 2C chain 0.2796 1 1
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0018 0.0018
Echinococcus multilocularis tubulin alpha chain 0.2098 0.7493 0.7493
Giardia lamblia Beta tubulin 0.2796 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0106 0.0106
Brugia malayi nuclear receptor NHR-67 0.0019 0.0028 0.0028
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0028 0.0028
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0028 0.0028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0163 0.0545 0.0545
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Leishmania major beta tubulin 0.2796 1 1
Echinococcus multilocularis muscleblind protein 0.0145 0.048 0.048
Loa Loa (eye worm) tubulin alpha-2 chain 0.2098 0.7493 0.7493
Trypanosoma cruzi epsilon tubulin, putative 0.1711 0.6103 0.6082
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0028 0.0028
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0018 0.0018
Leishmania major beta tubulin 0.2796 1 1
Loa Loa (eye worm) tubulin alpha 2 0.1379 0.4911 0.4911
Echinococcus granulosus Tubulin beta 2C chain 0.2796 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0106
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0106 0.0106
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0122 0.0398 0.0398
Trypanosoma brucei alpha tubulin, putative 0.0849 0.301 0.2971
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Leishmania major beta tubulin 0.2796 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0028 0.0028
Brugia malayi bZIP transcription factor family protein 0.0097 0.0307 0.0307
Toxoplasma gondii beta-tubulin, putative 0.2796 1 1
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0055 0.0055
Brugia malayi Cytochrome P450 family protein 0.0027 0.0055 0.0055
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0106 0.0106
Brugia malayi Tubulin beta chain 0.0849 0.301 0.301
Echinococcus granulosus alpha tubulin 0.2098 0.7493 0.7493
Echinococcus multilocularis tubulin alpha chain 0.2098 0.7493 0.7493
Echinococcus granulosus tubulin epsilon chain 0.1711 0.6103 0.6103
Trichomonas vaginalis conserved hypothetical protein 0.0719 0.2541 0.2472
Entamoeba histolytica tubulin alpha-1 chain 0.2098 0.7493 0.7438
Trypanosoma brucei epsilon tubulin 0.1711 0.6103 0.6082
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0028 0.0033
Echinococcus granulosus tubulin subunit TubB 0.2098 0.7493 0.7493
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0037
Loa Loa (eye worm) DR-78 0.0019 0.0028 0.0028
Trichomonas vaginalis tubulin beta chain, putative 0.2098 0.7493 0.7469
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0037 0.0037
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0213 0.0159
Loa Loa (eye worm) tubulin alpha chain 0.2098 0.7493 0.7493
Giardia lamblia Alpha-tubulin 0.2098 0.7493 0.7399
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.0264 0.0264
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0106 0.0106
Echinococcus multilocularis mitogen activated protein kinase 0.0111 0.0359 0.0359
Schistosoma mansoni thyroid hormone receptor 0.0163 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0019
Schistosoma mansoni alpha tubulin 0.2098 0.7493 0.7493
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0111 0.0359 0.0305
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0028 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0037 0.0037
Brugia malayi hypothetical protein 0.0019 0.0028 0.0028
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0028 0.0028
Schistosoma mansoni tubulin subunit alpha 0.2098 0.7493 0.7493
Brugia malayi hypothetical protein 0.0019 0.0028 0.0028
Trichomonas vaginalis tubulin beta chain, putative 0.2098 0.7493 0.7469
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0106 0.0106
Echinococcus granulosus tubulin alpha chain 0.2098 0.7493 0.7493
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0106 0.0106
Schistosoma mansoni jun-related protein 0.0079 0.0242 0.0242
Echinococcus multilocularis Tubulin alpha 1 chain 0.2098 0.7493 0.7493
Echinococcus multilocularis peroxisome assembly protein 26 0.2098 0.7493 0.7493
Plasmodium vivax tubulin epsilon chain, putative 0.1711 0.6103 0.4776
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0106 0.0106
Echinococcus multilocularis Tubulin beta 2C chain 0.2796 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0028 0.0028
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1612 0.5749 0.5591
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0861 0.3052 0.2794
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0106 0.0294
Echinococcus granulosus mitogen activated protein kinase 0.0111 0.0359 0.0359
Trypanosoma cruzi epsilon tubulin, putative 0.1711 0.6103 0.6082
Trypanosoma brucei zeta tubulin 0.2212 0.7905 0.7893
Schistosoma mansoni alpha tubulin 0.2098 0.7493 0.7493
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0101 0.0101
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0106 0.0106
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0106 0.0106
Mycobacterium tuberculosis Cell division protein FtsZ 0.0719 0.2541 0.5
Schistosoma mansoni thyroid hormone receptor 0.0163 0.0545 0.0545
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0106 0.0106
Echinococcus granulosus beta tubulin 0.2796 1 1
Brugia malayi conserved hypotetical protein 0.0019 0.0028 0.0028
Loa Loa (eye worm) tubulin alpha-3 chain 0.1248 0.4442 0.4442
Echinococcus multilocularis Ankyrin 0.0017 0.0019 0.0019
Trichomonas vaginalis tubulin beta chain, putative 0.0849 0.301 0.2945
Onchocerca volvulus 0.0849 0.301 1
Echinococcus granulosus jun protein 0.0097 0.0307 0.0307
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0019 0.0019
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0111 0.0359 0.0305
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0055 0.0055
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0028 0.0028
Trichomonas vaginalis tubulin alpha chain, putative 0.0849 0.301 0.2945
Schistosoma mansoni tubulin subunit epsilon 0.1711 0.6103 0.6103
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0028 0.0028
Plasmodium falciparum tubulin gamma chain 0.1713 0.6111 0.4786
Echinococcus granulosus tubulin alpha chain 0.2098 0.7493 0.7493
Toxoplasma gondii tubulin, putative 0.0143 0.0471 0.0116
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0101 0.0101
Mycobacterium ulcerans cell division protein FtsZ 0.0719 0.2541 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0106 0.0106
Brugia malayi nuclear receptor NHR-88 0.0041 0.0106 0.0106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0106
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0028 0.0028
Giardia lamblia Gamma tubulin 0.1713 0.6111 0.5966
Brugia malayi Tubulin alpha chain 0.0719 0.2541 0.2541
Loa Loa (eye worm) tubulin alpha chain 0.2098 0.7493 0.7493
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0359 0.027
Echinococcus multilocularis mitogen activated protein kinase 3 0.0111 0.0359 0.0359
Brugia malayi MAP kinase sur-1 0.0111 0.0359 0.0359
Brugia malayi nuclear receptor RXR 0.0019 0.0028 0.0028
Trypanosoma cruzi zeta tubulin, putative 0.2212 0.7905 0.7893
Trichomonas vaginalis tubulin alpha chain, putative 0.0849 0.301 0.2945
Leishmania major beta tubulin 0.2796 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.2098 0.7493 0.7469
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0359 0.0359
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0213 0.0213
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Echinococcus multilocularis tubulin beta 1 chain 0.2796 1 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0213 0.0213
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0028 0.0028
Leishmania major beta tubulin 0.2796 1 1
Entamoeba histolytica tubulin family protein 0.2796 1 1
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0106 0.0106
Brugia malayi hypothetical protein 0.0076 0.0232 0.0232
Trichomonas vaginalis tubulin epsilon chain, putative 0.0719 0.2541 0.2472
Plasmodium vivax tubulin beta chain, putative 0.2796 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0106 0.0106
Leishmania major beta tubulin 0.2796 1 1
Schistosoma mansoni tubulin subunit beta 0.2796 1 1
Trypanosoma brucei beta tubulin 0.1568 0.5591 0.5567
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0106 0.0106
Trichomonas vaginalis tubulin, putative 0.0849 0.301 0.2945
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0111 0.0359 0.0305
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0106
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0359 0.027
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0359 0.027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0106 0.0106
Echinococcus granulosus Tubulin beta 2C chain 0.2796 1 1
Loa Loa (eye worm) hypothetical protein 0.1248 0.4442 0.4442
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0018
Toxoplasma gondii beta tubulin 0.2796 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0028 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0106 0.0106
Echinococcus multilocularis tubulin subunit beta 0.2796 1 1
Schistosoma mansoni tubulin subunit alpha 0.0719 0.2541 0.2541
Leishmania major beta tubulin 0.2796 1 1
Schistosoma mansoni tubulin subunit beta 0.2796 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0106 0.0106
Echinococcus multilocularis hypothetical protein 0.2098 0.7493 0.7493
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0106 0.0106
Trichomonas vaginalis tubulin epsilon chain, putative 0.2796 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0114 0.0114
Loa Loa (eye worm) tubulin beta-2A chain 0.2796 1 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0018 0.0018
Echinococcus granulosus tubulin alpha chain 0.2098 0.7493 0.7493
Echinococcus granulosus death domain containing protein 0.0017 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0106 0.0106
Trypanosoma brucei alpha tubulin 0.2098 0.7493 0.7479
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0082
Echinococcus multilocularis beta tubulin 0.2796 1 1
Echinococcus granulosus tubulin subunit beta 0.2796 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0101 0.0101
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0111 0.0359 0.0305
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0719 0.2541 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.2098 0.7493 0.7469
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0213 0.0159
Loa Loa (eye worm) BEN-1 protein 0.2796 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.2796 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0106 0.0294
Schistosoma mansoni tubulin subunit beta 0.2796 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.1711 0.6103 0.6067
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0028 0.0028
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0028 0.0028
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0028 0.0028
Brugia malayi ecdysone receptor 0.0019 0.0028 0.0028
Echinococcus granulosus Tubulin alpha 1 chain 0.2098 0.7493 0.7493
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0398 0.0398
Trypanosoma brucei protein kinase, putative 0.0111 0.0359 0.0305
Loa Loa (eye worm) tubulin beta-4 chain 0.2796 1 1
Onchocerca volvulus 0.0019 0.0028 0.0033
Echinococcus multilocularis tubulin, beta 4A class IVa 0.2796 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0028 0.0028
Echinococcus granulosus tubulin delta chain 0.0719 0.2541 0.2541
Echinococcus multilocularis tubulin epsilon chain 0.1711 0.6103 0.6103
Schistosoma mansoni tubulin subunit beta 0.0719 0.2541 0.2541
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0106 0.0106
Trypanosoma cruzi tubulin delta chain 0.1612 0.5749 0.5726
Echinococcus granulosus beta tubulin 0.2796 1 1
Loa Loa (eye worm) tubulin beta chain 0.0719 0.2541 0.2541
Echinococcus multilocularis tubulin gamma 1 chain 0.1713 0.6111 0.6111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0106 0.0106
Echinococcus granulosus muscleblind protein 0.0145 0.048 0.048
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0851 0.0851
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0101 0.0101
Plasmodium vivax tubulin gamma chain, putative 0.1713 0.6111 0.4786
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0037 0.0037
Echinococcus granulosus Ankyrin 0.0017 0.0019 0.0019
Brugia malayi Uncoordinated protein 44 0.0017 0.0018 0.0018
Loa Loa (eye worm) BEN-1 protein 0.2796 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0529 0.186 0.186
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0028 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0055 0.0055
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0106 0.0106
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0719 0.2541 0.2472
Schistosoma mansoni coup transcription factor 0.0041 0.0106 0.0106
Trypanosoma brucei alpha tubulin 0.2098 0.7493 0.7479
Brugia malayi Death domain containing protein 0.0017 0.0018 0.0018
Trichomonas vaginalis tubulin epsilon chain, putative 0.2098 0.7493 0.7469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0106 0.0106
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0106 0.0106
Echinococcus multilocularis tubulin alpha 1C chain 0.2098 0.7493 0.7493
Trichomonas vaginalis tubulin gamma chain, putative 0.0719 0.2541 0.2472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0106 0.0106
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0106 0.0106
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0213 0.0159
Echinococcus multilocularis tubulin delta chain 0.0719 0.2541 0.2541
Schistosoma mansoni tubulin subunit alpha 0.2098 0.7493 0.7493
Loa Loa (eye worm) hypothetical protein 0.0145 0.048 0.048
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0213 0.0213
Leishmania major beta tubulin 0.2796 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0097 0.0307 0.0307
Brugia malayi alpha-tubulin 0.2098 0.7493 0.7493
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0106 0.0106
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0106 0.0106
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0028 0.0028
Schistosoma mansoni nuclear receptor 0.0019 0.0028 0.0028
Toxoplasma gondii alpha-tubulin I, putative 0.2098 0.7493 0.7399
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0106
Echinococcus granulosus tubulin alpha 1C chain 0.2098 0.7493 0.7493
Trypanosoma cruzi beta tubulin, putative 0.2796 1 1
Echinococcus multilocularis tubulin alpha chain 0.2098 0.7493 0.7493
Echinococcus multilocularis muscleblind protein 1 0.0145 0.048 0.048
Trichomonas vaginalis tubulin beta chain, putative 0.2098 0.7493 0.7469
Trichomonas vaginalis tubulin, putative 0.2796 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0106 0.0106
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0106 0.0106
Echinococcus granulosus peroxisome assembly protein 26 0.2098 0.7493 0.7493
Trichomonas vaginalis tubulin beta chain, putative 0.2098 0.7493 0.7469
Leishmania major gamma-tubulin 0.1713 0.6111 0.6089
Onchocerca volvulus 0.0076 0.0232 0.0714
Brugia malayi hypothetical protein 0.0022 0.0037 0.0037
Echinococcus granulosus tubulin alpha chain 0.2098 0.7493 0.7493
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0037 0.0037
Trichomonas vaginalis tubulin beta chain, putative 0.2098 0.7493 0.7469
Echinococcus granulosus Tubulin beta 2C chain 0.2796 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0028 0.0028
Trypanosoma brucei beta tubulin 0.2796 1 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0111 0.0359 0.0305
Entamoeba histolytica tubulin family protein 0.2796 1 1
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Trypanosoma brucei epsilon tubulin 0.1711 0.6103 0.6082
Trypanosoma brucei alpha tubulin 0.2098 0.7493 0.7479
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0359 0.027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Trypanosoma brucei alpha tubulin 0.2098 0.7493 0.7479
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0851 0.0851
Leishmania major beta tubulin 0.2796 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0106 0.0106
Leishmania major beta tubulin 0.2796 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0106 0.0106
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Trichomonas vaginalis conserved hypothetical protein 0.0719 0.2541 0.2472
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0028 0.0028
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0028 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0106 0.0106
Trypanosoma cruzi zeta tubulin, putative 0.2212 0.7905 0.7893
Entamoeba histolytica tubulin gamma chain 0.1713 0.6111 0.6026
Echinococcus multilocularis Tubulin alpha 1 chain 0.2098 0.7493 0.7493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0106 0.0106
Brugia malayi nuclear receptor RXR 0.0022 0.0037 0.0037
Trichomonas vaginalis tubulin alpha chain, putative 0.0849 0.301 0.2945
Echinococcus multilocularis tubulin alpha 0.1568 0.5591 0.5591
Trypanosoma cruzi tubulin gamma chain 0.1713 0.6111 0.6089
Echinococcus granulosus tubulin alpha 3 chain 0.2098 0.7493 0.7493
Leishmania major beta tubulin 0.2796 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.2796 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0037 0.0037
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1248 0.4442 0.439
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0106
Schistosoma mansoni tubulin subunit beta 0.2796 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.2098 0.7493 0.7493
Loa Loa (eye worm) beta-tubulin 0.2796 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Entamoeba histolytica tubulin alpha chain, putative 0.2098 0.7493 0.7438
Trichomonas vaginalis tubulin epsilon chain, putative 0.2796 1 1
Brugia malayi Tubulin gamma chain 0.1713 0.6111 0.6111
Schistosoma mansoni netrin receptor unc5 0.0017 0.0018 0.0018
Leishmania major beta tubulin 0.2796 1 1
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0106 0.0106
Plasmodium vivax tubulin alpha chain, putative 0.2098 0.7493 0.6639
Loa Loa (eye worm) tubulin alpha 2 0.1379 0.4911 0.4911
Trichomonas vaginalis tubulin alpha chain, putative 0.1568 0.5591 0.5551
Onchocerca volvulus 0.0041 0.0106 0.0294
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0037
Trichomonas vaginalis tubulin gamma chain, putative 0.1713 0.6111 0.6075
Trypanosoma cruzi tubulin delta chain 0.1612 0.5749 0.5726
Leishmania major zeta tubulin, putative 0.2212 0.7905 0.7893
Echinococcus multilocularis tubulin alpha 1C chain 0.2098 0.7493 0.7493
Echinococcus multilocularis Tubulin beta 2C chain 0.2796 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0849 0.301 0.2945
Brugia malayi Cytochrome P450 family protein 0.0027 0.0055 0.0055
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0018 0.0018
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1379 0.4911 0.4864
Loa Loa (eye worm) hypothetical protein 0.1379 0.4911 0.4911
Plasmodium falciparum tubulin beta chain 0.2796 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.2796 1 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0028 0.0028
Schistosoma mansoni tubulin subunit alpha 0.2098 0.7493 0.7493
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Brugia malayi steroid hormone receptor 0.0041 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0106 0.0106
Loa Loa (eye worm) alpha-tubulin 0.2098 0.7493 0.7493
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0213 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0106 0.0106
Echinococcus multilocularis tubulin alpha 3 chain 0.2098 0.7493 0.7493
Treponema pallidum cell division protein FtsZ 0.0719 0.2541 0.5
Echinococcus granulosus tubulin beta 4A class IVa 0.2796 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0028 0.0033
Brugia malayi nuclear hormone receptor 0.0041 0.0106 0.0106
Schistosoma mansoni zinc finger protein 0.0019 0.0028 0.0028
Loa Loa (eye worm) alpha-tubulin 0.2098 0.7493 0.7493
Giardia lamblia Beta tubulin 0.2796 1 1
Trypanosoma brucei epsilon tubulin 0.1568 0.5591 0.5567
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0018
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0028 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0106 0.0106
Trichomonas vaginalis tubulin alpha chain, putative 0.2796 1 1
Loa Loa (eye worm) tubulin beta chain 0.2796 1 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.048 0.048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0106 0.0106
Loa Loa (eye worm) tubulin gamma chain 0.1713 0.6111 0.6111
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1568 0.5591 0.5427
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.2098 0.7493 0.7493
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0028 0.0028
Brugia malayi Tubulin alpha-2 chain 0.2098 0.7493 0.7493
Trypanosoma brucei tubulin delta chain 0.1612 0.5749 0.5726
Trypanosoma brucei beta tubulin 0.2796 1 1
Brugia malayi tailless protein 0.0019 0.0028 0.0028
Echinococcus multilocularis tubulin subunit TubB 0.2098 0.7493 0.7493
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Brugia malayi Tubulin alpha-2 chain 0.2098 0.7493 0.7493
Trichomonas vaginalis tubulin, putative 0.0863 0.306 0.2996
Leishmania major beta tubulin 0.2796 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.2098 0.7493 0.7493
Toxoplasma gondii alpha tubulin TUBA1 0.2098 0.7493 0.7399
Schistosoma mansoni nuclear receptor 0.0019 0.0028 0.0028
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0111 0.0359 0.0305
Trypanosoma brucei beta tubulin 0.2796 1 1
Giardia lamblia Alpha-tubulin 0.2098 0.7493 0.7399
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0094 0.0297 0.0297
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0106 0.0106
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Schistosoma mansoni hypothetical protein 0.0079 0.0242 0.0242
Trypanosoma brucei zeta tubulin, putative 0.2212 0.7905 0.7893
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0028 0.0028
Brugia malayi ecdysteroid receptor 0.0041 0.0106 0.0106
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0213 0.0213
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0106
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0037
Plasmodium falciparum tubulin epsilon chain, putative 0.1711 0.6103 0.4776
Echinococcus multilocularis tubulin alpha chain 0.2098 0.7493 0.7493
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0114 0.0114
Echinococcus multilocularis beta tubulin 0.2796 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.2796 1 1
Schistosoma mansoni tubulin subunit delta 0.0719 0.2541 0.2541
Echinococcus granulosus tubulin alpha 0.1568 0.5591 0.5591
Schistosoma mansoni alpha tubulin 0.2098 0.7493 0.7493
Schistosoma mansoni tubulin subunit beta 0.2796 1 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0398 0.0398
Leishmania major epsilon tubulin, putative 0.1711 0.6103 0.6082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0106
Leishmania major alpha tubulin 0.2098 0.7493 0.7479
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0028
Trypanosoma brucei beta tubulin 0.2796 1 1
Echinococcus multilocularis jun protein 0.0097 0.0307 0.0307
Echinococcus multilocularis tubulin alpha chain 0.2098 0.7493 0.7493
Echinococcus granulosus tubulin beta 1 chain 0.2796 1 1
Brugia malayi hypothetical protein 0.0022 0.0037 0.0037
Echinococcus granulosus tubulin gamma 1 chain 0.1713 0.6111 0.6111

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.58 uM Inhibition of protein synthesis in Escherichia coli S30 extract by translation assay ChEMBL. 18951792

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Escherichia coli ChEMBL23 18951792

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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