Detailed information for compound 992713

Basic information

Technical information
  • TDR Targets ID: 992713
  • Name: [(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl] (4a S,6aR,6aS,6bR,8R,8aR,9R,10R,11S,12aR,14bS)-8, 10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b, 9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12 ,13,14b-tetradecahydropicene-4a-carboxylate
  • MW: 636.813 | Formula: C35H56O10
  • H donors: 7 H acceptors: 8 LogP: 2.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@]1(C)[C@@H](O)[C@@H](O)C[C@]2([C@H]1[C@H](O)C[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(CC1)(C)C)C(=O)O[C@@H]1OC[C@@H]([C@@H]([C@H]1O)O)O)C)C
  • InChi: 1S/C35H56O10/c1-30(2)9-11-35(29(43)45-28-25(41)24(40)22(39)16-44-28)12-10-33(5)18(19(35)13-30)7-8-23-31(3)14-21(38)27(42)32(4,17-36)26(31)20(37)15-34(23,33)6/h7,19-28,36-42H,8-17H2,1-6H3/t19-,20+,21-,22-,23+,24-,25+,26+,27-,28-,31+,32-,33+,34+,35-/m0/s1
  • InChiKey: LHEBDLOFQQYJHH-FTTCVYLCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2S,3R,4S,5S)-3,4,5-trihydroxytetrahydropyran-2-yl] (4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11S,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
  • (4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11S,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid [(2S,3R,4S,5S)-3,4,5-trihydroxy-2-tetrahydropyranyl] ester
  • (4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11S,12aR,14bS)-8,10,11-trihydroxy-2,2,6a,6b,9,12a-hexamethyl-9-methylol-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid [(2S,3R,4S,5S)-3,4,5-trihydroxytetrahydropyran-2-yl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis carbonic anhydrase 0.0107 0.1347 0.1331
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0522 0.0504
Onchocerca volvulus 0.0205 0.3018 0.3005
Echinococcus granulosus xaa Pro dipeptidase 0.0076 0.0812 0.0812
Schistosoma mansoni carbonic anhydrase 0.0107 0.1347 0.1331
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0076 0.0812 0.0795
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0076 0.0812 1
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0513 0.0495
Echinococcus granulosus geminin 0.0522 0.8442 0.8442
Loa Loa (eye worm) CYP4Cod1 0.003 0.0023 0.0005
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0119 0.1542 0.1523
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0076 0.0812 0.0795
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0076 0.0812 0.0795
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0035 0.0105 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1048 0.1048
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0545 0.0528
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0513 0.0495
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0105 0.0086
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0076 0.0812 0.5
Brugia malayi Cytochrome P450 family protein 0.003 0.0023 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0545 0.0545
Plasmodium vivax FACT complex subunit SPT16, putative 0.0076 0.0812 0.0795
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0545 0.0528
Brugia malayi metallopeptidase family M24 containing protein 0.0076 0.0812 0.0795
Echinococcus granulosus methionine aminopeptidase type I 0.0076 0.0812 0.0812
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Brugia malayi metallopeptidase family M24 containing protein 0.0076 0.0812 0.0795
Loa Loa (eye worm) norepinephrine transporter 0.0205 0.3018 0.3005
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0545 0.3436
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0076 0.0812 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0076 0.0812 0.0795
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0076 0.0812 0.079
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Loa Loa (eye worm) hypothetical protein 0.0205 0.3018 0.3005
Schistosoma mansoni hypothetical protein 0.0522 0.8442 0.8439
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0076 0.0812 0.519
Echinococcus multilocularis carbonic anhydrase 0.0107 0.1347 0.1331
Plasmodium vivax methionine aminopeptidase 2, putative 0.0613 1 1
Plasmodium falciparum methionine aminopeptidase 2 0.0613 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1198 0.1182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1048 0.1031
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0076 0.0812 0.0795
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0076 0.0812 0.0714
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Toxoplasma gondii hypothetical protein 0.0107 0.1347 0.1331
Echinococcus multilocularis transient receptor potential cation channel 0.0347 0.5453 0.5444
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0427 0.0405
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0076 0.0812 0.0795
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0513 0.0495
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0194 0.0171
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0076 0.0812 0.0795
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0076 0.0812 0.1676
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0513 0.0495
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0588 0.057
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Mycobacterium ulcerans aminopeptidase 0.0076 0.0812 0.519
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0545 0.0523
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Brugia malayi metallopeptidase family M24 containing protein 0.0076 0.0812 0.0795
Plasmodium vivax peptidase, putative 0.0076 0.0812 0.0795
Echinococcus multilocularis Proliferation associated protein 2G4 0.0076 0.0812 0.0795
Plasmodium falciparum carbonic anhydrase 0.0107 0.1347 0.1255
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0613 1 1
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0076 0.0812 0.0795
Loa Loa (eye worm) hypothetical protein 0.0067 0.0664 0.0646
Loa Loa (eye worm) carbonic anhydrase 3 0.0198 0.2903 0.2889
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0076 0.0812 0.0795
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.2903 0.2886
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0023 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0194 0.0175
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.1347 0.1331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Brugia malayi TAR-binding protein 0.0063 0.0588 0.057
Treponema pallidum sodium- and chloride- dependent transporter 0.0205 0.3018 1
Loa Loa (eye worm) initiation factor 2-associated protein 0.0613 1 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.0105 0.0086
Echinococcus multilocularis ankyrin repeat protein 0.0336 0.5268 0.5259
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0067 0.0664 0.0646
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0076 0.0812 0.079
Toxoplasma gondii ABC1 family protein 0.004 0.0194 0.0175
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0035 0.0105 0.0086
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0076 0.0812 0.079
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0545 0.0528
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0194 0.0175
Loa Loa (eye worm) serotonin transporter b 0.0205 0.3018 0.3005
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0194 0.0175
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0198 0.2903 0.2889
Mycobacterium ulcerans beta-lactamase 0.004 0.0194 0.1121
Onchocerca volvulus 0.0035 0.0105 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0076 0.0812 0.0714
Echinococcus multilocularis methionyl aminopeptidase 2 0.0613 1 1
Brugia malayi Pre-SET motif family protein 0.0207 0.306 0.3047
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0035 0.0105 0.0105
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0044 0.0025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0194 0.1121
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0119 0.1542 0.1527
Mycobacterium ulcerans hypothetical protein 0.004 0.0194 0.1121
Brugia malayi beta-lactamase family protein 0.004 0.0194 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1048 0.1031
Onchocerca volvulus 0.0035 0.0105 0.0086
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0076 0.0812 0.0714
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0025
Loa Loa (eye worm) hypothetical protein 0.0099 0.1198 0.1182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0194 0.0175
Echinococcus granulosus tar DNA binding protein 0.0063 0.0588 0.0588
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1048 0.1031
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0076 0.0812 0.0714
Toxoplasma gondii hypothetical protein 0.0035 0.0105 0.0086
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0119 0.1542 0.1527
Echinococcus multilocularis xaa Pro dipeptidase 0.0076 0.0812 0.0795
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1198 0.1182
Loa Loa (eye worm) methionine aminopeptidase type I 0.0076 0.0812 0.0795
Loa Loa (eye worm) hypothetical protein 0.0107 0.1347 0.1331
Onchocerca volvulus 0.0076 0.0812 0.0795
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.1542 0.1542
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0664 0.0646
Echinococcus multilocularis serotonin transporter 0.0205 0.3018 0.3005
Brugia malayi hypothetical protein 0.0035 0.0105 0.0086
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Echinococcus granulosus methionyl aminopeptidase 2 0.0613 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.306 0.3047
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Leishmania major methionine aminopeptidase 2, putative 0.0613 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0044 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1198 0.1182
Plasmodium vivax amine transporter, putative 0.0035 0.0105 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0613 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0025
Trypanosoma cruzi aminopeptidase P1, putative 0.0076 0.0812 0.079
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Toxoplasma gondii methionine aminopeptidase 0.0076 0.0812 0.0795
Onchocerca volvulus 0.004 0.0194 0.0175
Plasmodium vivax hypothetical protein, conserved 0.004 0.0194 0.0175
Brugia malayi hypothetical protein 0.0054 0.0427 0.0409
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.1347 0.1331
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0076 0.0812 0.079
Mycobacterium tuberculosis Dipeptidase PepE 0.0076 0.0812 0.1676
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.1347 0.1331
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0613 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0198 0.2903 0.2889
Echinococcus multilocularis xaa Pro dipeptidase 0.0076 0.0812 0.0795
Chlamydia trachomatis aminopeptidase P 0.0076 0.0812 1
Echinococcus multilocularis FACT complex subunit SPT16 0.0076 0.0812 0.0795
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.1542 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0076 0.0812 0.0795
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0613 1 1
Mycobacterium ulcerans dipeptidase PepE 0.0076 0.0812 0.519
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0076 0.0812 0.1676
Trypanosoma brucei carbonic anhydrase-like protein 0.0198 0.2903 0.2886
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.2903 0.2889
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0427 0.0409
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0613 1 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.3018 0.3005
Leishmania major hypothetical protein, conserved 0.0054 0.0427 0.0405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1048 0.1031
Loa Loa (eye worm) beta-lactamase 0.004 0.0194 0.0175
Brugia malayi beta-lactamase family protein 0.004 0.0194 0.0175
Echinococcus granulosus ankyrin repeat protein 0.0336 0.5268 0.5268
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0336 0.5268 0.5259
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0194 0.0171
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0513 0.0513
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.1347 0.1331
Loa Loa (eye worm) hypothetical protein 0.0076 0.0812 0.0795
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0076 0.0812 0.0812
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.1542 1
Echinococcus granulosus carbonic anhydrase 0.0107 0.1347 0.1347
Trypanosoma cruzi aminopeptidase P, putative 0.0076 0.0812 0.079
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0613 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0513 0.0513
Leishmania major transcription factor-like protein 0.0076 0.0812 0.079
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0427 0.0409
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0588 0.057
Mycobacterium ulcerans methionine aminopeptidase 0.0076 0.0812 0.519
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.0035 0.0105 0.0086
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.1344 0.1328
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Toxoplasma gondii transcriptional elongation factor FACT140 0.0076 0.0812 0.0795
Schistosoma mansoni peptidase 0.0076 0.0812 0.0795
Echinococcus granulosus carbonic anhydrase 0.0107 0.1347 0.1347
Loa Loa (eye worm) hypothetical protein 0.0076 0.0812 0.0795
Echinococcus multilocularis carbonic anhydrase II 0.0198 0.2903 0.2889
Echinococcus granulosus carbonic anhydrase II 0.0198 0.2903 0.2903
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0194 0.0171
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0076 0.0812 0.0812
Onchocerca volvulus 0.0237 0.356 0.3548
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0076 0.0812 0.519
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0427 0.0326
Loa Loa (eye worm) hypothetical protein 0.0205 0.3018 0.3005
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0035 0.0105 0.0086
Loa Loa (eye worm) solute carrier family 6 member 4 0.0205 0.3018 0.3005
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0194 0.1121
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0023 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0076 0.0812 0.0795
Leishmania major carbonic anhydrase-like protein 0.0198 0.2903 0.2886
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0044 0.0044
Chlamydia trachomatis methionine aminopeptidase 0.0076 0.0812 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0035 0.0105 0.0086
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0613 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0613 1 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0588 0.057
Entamoeba histolytica methionine aminopeptidase, putative 0.0613 1 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0044 0.0025
Echinococcus multilocularis sodium and chloride dependent glycine 0.0035 0.0105 0.0086
Brugia malayi RNA binding protein 0.0063 0.0588 0.057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0044 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0044 0.0025
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0427 0.0405
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0076 0.0812 0.079
Brugia malayi Methionine aminopeptidase protein type I 0.0076 0.0812 0.0795
Onchocerca volvulus 0.0035 0.0105 0.0086
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.0105 0.0086
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0205 0.3018 0.3005
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0025
Echinococcus granulosus sodium and chloride dependent glycine 0.0035 0.0105 0.0105
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0613 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1048 0.1031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.1542 0.1527
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0044 0.0025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0513 0.0495
Echinococcus granulosus transient receptor potential cation channel 0.0347 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0076 0.0812 0.0795
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0076 0.0812 0.0795
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0076 0.0812 0.0714
Echinococcus granulosus Proliferation associated protein 2G4 0.0076 0.0812 0.0812
Echinococcus granulosus xaa pro aminopeptidase 0.0076 0.0812 0.0812
Schistosoma mansoni hypothetical protein 0.0522 0.8442 0.8439
Onchocerca volvulus 0.004 0.0194 0.0175
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.1347 0.1331
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0545 0.3436
Trypanosoma brucei methionine aminopeptidase, putative 0.0076 0.0812 0.079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0613 1 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0035 0.0105 0.0086
Echinococcus granulosus xaa Pro dipeptidase 0.0076 0.0812 0.0812
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0076 0.0812 0.0795
Leishmania major hypothetical protein, conserved 0.0076 0.0812 0.079
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0588 0.057
Trichomonas vaginalis set domain proteins, putative 0.0236 0.3551 0.3423
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0076 0.0812 0.5
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0035 0.0105 0.0105
Leishmania major hypothetical protein, conserved 0.004 0.0194 0.0171
Echinococcus multilocularis methionine aminopeptidase, type I 0.0076 0.0812 0.0795
Loa Loa (eye worm) hypothetical protein 0.0054 0.0427 0.0409
Giardia lamblia Methionine aminopeptidase 0.0613 1 1
Brugia malayi hypothetical protein 0.0035 0.0102 0.0083
Schistosoma mansoni hypothetical protein 0.0107 0.1347 0.1331
Toxoplasma gondii creatinase domain-containing protein 0.0076 0.0812 0.0795
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0076 0.0812 0.079
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Echinococcus granulosus FACT complex subunit SPT16 0.0076 0.0812 0.0812
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1048 0.1031
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0076 0.0812 0.079
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.3882 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0076 0.0812 0.0795
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0076 0.0812 0.0795
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0076 0.0812 0.0795
Brugia malayi beta-lactamase 0.004 0.0194 0.0175
Brugia malayi Cytochrome P450 family protein 0.003 0.0023 0.0005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1048 0.1048
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0119 0.1542 0.3657
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0198 0.2903 0.2889
Mycobacterium ulcerans dipeptidase 0.0076 0.0812 0.519
Onchocerca volvulus 0.004 0.0194 0.0175
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0545 0.3436
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0194 0.0194
Echinococcus granulosus carbonic anhydrase 0.0107 0.1347 0.1347
Schistosoma mansoni sodium/chloride dependent transporter 0.0205 0.3018 0.3005
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0107 0.1347 0.1331
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0035 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Trypanosoma brucei Metallopeptidase family M24, putative 0.0076 0.0812 0.079
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0076 0.0812 0.0795
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.2903 0.2886
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0035 0.0105 0.0105
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Brugia malayi jmjC domain containing protein 0.0059 0.0513 0.0495
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0076 0.0812 0.0795
Toxoplasma gondii peptidase D, putative 0.0076 0.0812 0.0795
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0076 0.0812 0.0795
Echinococcus multilocularis carbonic anhydrase 0.0107 0.1347 0.1331
Brugia malayi Cytochrome P450 family protein 0.0059 0.0522 0.0504
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0076 0.0812 0.0795
Mycobacterium ulcerans lipase LipD 0.004 0.0194 0.1121
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Echinococcus granulosus serotonin transporter 0.0205 0.3018 0.3018
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.2903 0.2889
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0613 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0194 0.0175
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.1347 0.1331
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0107 0.1347 0.1331
Echinococcus granulosus GPCR family 2 0.0031 0.0044 0.0044
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0076 0.0812 0.1676
Loa Loa (eye worm) RNA binding protein 0.0063 0.0588 0.057
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1048 0.1031
Loa Loa (eye worm) hypothetical protein 0.0107 0.1347 0.1331
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0205 0.3018 0.3005
Echinococcus multilocularis geminin 0.0522 0.8442 0.8439
Loa Loa (eye worm) DNA-binding protein 0.0076 0.0812 0.0795
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0107 0.1347 0.1331
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Plasmodium falciparum aminopeptidase P 0.0076 0.0812 0.0714
Onchocerca volvulus Dipeptidase C homolog 0.0076 0.0812 0.0795
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0427 0.0326
Echinococcus granulosus sodium and chloride dependent glycine 0.0035 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0107 0.1347 0.1331
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0076 0.0812 0.079
Brugia malayi jmjC domain containing protein 0.0059 0.0513 0.0495
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0025
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0076 0.0812 1
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0513 0.0495
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0427 0.0405
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Echinococcus multilocularis xaa pro aminopeptidase 0.0076 0.0812 0.0795
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Echinococcus multilocularis sodium and chloride dependent glycine 0.0035 0.0105 0.0086
Toxoplasma gondii methionine aminopeptidase 0.0076 0.0812 0.0795
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0035 0.0105 0.0086
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0545 0.0528
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0545 0.0954

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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