Detailed view for LOAG_00060

Basic information

TDR Targets ID: 935269
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.1767 | Length (AA): 415 | MW (Da): 47789 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF16499   Alpha galactosidase A

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0003824   catalytic activity  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 412 4nzj (A) 106 500 32.00 0 1 1.25147 0.12
20 409 1ktb (A) 1 385 48.00 0 1 1.54116 -0.92
20 409 3hg3 (A) 32 418 44.00 0 1 1.50516 -1.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127620)

Species Accession Gene Product
Arabidopsis thaliana AT3G56310   melibiase family protein
Arabidopsis thaliana AT5G08380   alpha-galactosidase 1
Arabidopsis thaliana AT5G08370   alpha-galactosidase 2
Brugia malayi Bm1_51545   Melibiase family protein
Caenorhabditis elegans CELE_R07B7.11   Protein GANA-1
Dictyostelium discoideum DDB_G0271490   hypothetical protein
Dictyostelium discoideum DDB_G0291524   glycoside hydrolase family 27 protein
Drosophila melanogaster Dmel_CG7997   CG7997 gene product from transcript CG7997-RB
Drosophila melanogaster Dmel_CG5731   CG5731 gene product from transcript CG5731-RA
Echinococcus granulosus EgrG_000340500   Alpha N acetylgalactosaminidase
Echinococcus multilocularis EmuJ_000340500   Alpha N acetylgalactosaminidase
Echinococcus multilocularis EmuJ_000340400   Glycoside hydrolase, family 27
Homo sapiens ENSG00000102393   galactosidase, alpha
Homo sapiens ENSG00000198951   N-acetylgalactosaminidase, alpha-
Loa Loa (eye worm) LOAG_00060   hypothetical protein
Mus musculus ENSMUSG00000031266   galactosidase, alpha
Mus musculus ENSMUSG00000022453   N-acetyl galactosaminidase, alpha
Neospora caninum NCLIV_054050   hypothetical protein
Oryza sativa 4348988   Os10g0493600
Oryza sativa 4348984   Os10g0492900
Oryza sativa 4344290   Os07g0679300
Schistosoma japonicum Sjp_0023240   Alpha-N-acetylgalactosaminidase precursor, putative
Schistosoma japonicum Sjp_0023210   expressed protein
Schistosoma japonicum Sjp_0023250   Alpha-N-acetylgalactosaminidase, putative
Schistosoma japonicum Sjp_0023260   ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative
Schistosoma japonicum Sjp_0107620   Alpha-N-acetylgalactosaminidase, putative
Schistosoma japonicum Sjp_0023220   Alpha-N-acetylgalactosaminidase, putative
Schistosoma mansoni Smp_089290   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_179260   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_179250   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_186710   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_170830   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_170840   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schmidtea mediterranea mk4.003634.02  
Schmidtea mediterranea mk4.005290.02  
Schmidtea mediterranea mk4.000843.06  
Toxoplasma gondii TGME49_309930   melibiase subfamily protein
Trichomonas vaginalis TVAG_145340   alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative

Essentiality

LOAG_00060 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_309930 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens galactosidase, alpha Compounds References
Coffea arabica Alpha-galactosidase Compounds References
Rattus norvegicus Alpha-galactosidase A Compounds References
Coffea arabica Alpha-galactosidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0082 0.259 0.8091
0.0082 0.5919 1
0.0071 0.3077 0.4255
0.0358 0.4952 0.4951
0.0082 0.3989 0.279
0.0072 0.2902 0.7757
0.0079 0.4205 0.465
0.0077 0.5839 0.571
0.0075 0.3909 0.3471
0.0082 0.6062 1
0.0066 0.315 0.3087
0.008 0.2693 0.2693
0.0071 0.3863 0.4136
0.0082 0.3144 1
0.0082 0.3939 0.3881
0.0153 0.3366 0.9085
0.0069 0.3002 0.3146
0.0337 0.6122 0.6121
0.0082 0.5343 1
0.0067 0.2929 0.3456
0.0388 0.2703 0.5226
0.0344 0.3411 0.4079
0.0082 0.3755 0.5172
0.0277 0.2977 0.3149
0.0344 0.3411 0.4079
0.0079 0.2605 0.2639
0.0082 0.357 0.357
0.0082 0.2987 0.2987
0.0082 0.6061 0.8414
0.0067 0.3863 1
0.022 0.3608 0.3548
0.0074 0.398 1
0.0082 0.3688 0.3688
0.0082 0.5581 1
0.0071 0.391 0.5614
0.0082 0.3182 0.4218
0.0347 0.32 0.3607
0.0216 0.4059 0.4004
0.0076 0.6121 1
0.0076 0.4307 1
0.007 0.507 0.507
0.0074 0.2553 0.2574
0.0082 0.3618 0.352
0.0078 0.2767 1
0.0071 0.2969 0.5752
0.0082 0.2765 0.5774
0.0082 0.3203 0.3203
0.0073 0.6119 1
0.0082 0.3951 0.3857
0.0076 0.2723 0
0.0077 0.381 0.4061
0.0082 0.513 0.0885
0.0148 0.3707 0.3863
0.0075 0.3863 0.4671
0.0067 0.6039 1
0.0082 0.2534 0.2534
0.0082 0.2988 0.3471
0.0077 0.513 0.4921
0.0066 0.351 0.3337
0.0076 0.3036 0.2792
0.007 0.4589 0.4206
0.0229 0.2785 0.3046
0.0082 0.3869 1
0.0081 0.4322 1
0.0068 0.3344 0.6261
0.0082 0.3989 0
0.0082 0.5623 1
0.0082 0.6119 0.5
0.0082 0.2585 0.2657
0.008 0.3323 0.3323
0.0082 0.6119 0.5
0.0055 0.2547 0.2552
0.007 0.2686 0.438
0.0082 0.6119 1
0.0059 0.3076 0.3076
0.0082 0.3334 0.9737
0.0067 0.5919 1
0.0289 0.3225 0.3207
0.0441 0.5029 0.5026
0.0082 0.362 0.362
0.0067 0.3449 0.3449
0.0277 0.2977 0.3149
0.0078 0.3515 1
0.008 0.3143 0.3143
0.0082 0.5919 1
0.007 0.6121 0.784
0.0076 0.3863 0.5168
0.008 0.383 0.427
0.0078 0.398 1
0.0074 0.5919 1
0.0435 0.4776 0.4771
0.0079 0.3 0.48
0.0334 0.6481 0.6765
0.0344 0.4074 0.4071
0.0071 0.261 1
0.0278 0.2517 0.282
0.0378 0.4119 0.4119
0.0273 0.2591 0.5381
0.0082 0.5919 1
0.0082 0.3635 0.3635
0.0383 0.4857 0.5266
0.0146 0.3472 0.3618
0.008 0.2521 1
0.0079 0.6184 1
0.0276 0.3867 0.4009
0.0082 0.6162 0.7431
0.007 0.504 0.504
0.008 0.5911 0.6709
0.0146 0.3109 0.4502
0.0073 0.2743 0.2743
0.0066 0.2988 0.3129
0.0082 0.5545 0.7612
0.0082 0.6062 1
0.0082 0.654 1
0.0082 0.513 0.4576
0.0075 0.3431 1
0.0134 0.2594 0.2481
0.0082 0.2637 0.324
0.0082 0.6039 1
0.0079 0.6119 0.5
0.0079 0.2605 0.2639
0.0079 0.3 0.48
0.0081 0.6119 0.6455
0.0067 0.5993 1
0.0266 0.3195 0.3564
0.0082 0.2534 0.2897
0.0074 0.315 0.3087
0.0081 0.6119 0.5
0.0069 0.3451 0.3247
0.0277 0.2977 0.3149
0.0082 0.2968 0.2968
0.0082 0.2685 0.4071
0.0082 0.453 0.453
0.0082 0.2988 0.3129
0.0082 0.6299 1
0.0388 0.5179 0.5155
0.0082 0.3144 0.2536
0.0073 0.3886 0.3886
0.008 0.495 0.4855
0.007 0.2734 0.4056
0.0075 0.2646 0.4636
0.0082 0.5581 1
0.0075 0.3207 0.3296
0.0076 0.5919 1
0.0227 0.3013 0.3003
0.0082 0.2688 0.3071
0.0072 0.398 1
0.0067 0.3128 0.5598
0.0082 0.6304 1
0.0384 0.4139 0.4139
0.0082 0.3627 0.3627
0.0074 0.2608 0.2684
0.0066 0.3639 0.6636
0.0076 0.375 0.4399
0.0073 0.3472 0.6634
0.0082 0.6056 1
0.0082 0.3791 0.3791
0.0073 0.2743 0.2743
0.0082 0.4177 1
0.0072 0.29 0.3926
0.0082 0.3471 0.3471
0.0068 0.3204 0.1651
0.0074 0.274 0.274
0.0081 0.2709 0.3368
0.0082 0.6056 1
0.0076 0.4341 0.4341
0.0082 0.398 1
0.0078 0.4154 0
0.0082 0.6566 1
0.0082 0.513 0.4921
0.0066 0.3291 0.4544
0.0081 0.2582 0.2582
0.0082 0.398 1
0.0082 0.3278 0.5509
0.0069 0.3385 0.3719
0.0082 0.4474 0.2246
0.0075 0.4099 0.5532
0.0072 0.3735 1
0.0071 0.3823 0.3412
0.081 0.2911 0.3164
0.0075 0.4125 0.4071
0.0148 0.3057 1
0.0082 0.6039 1
0.0137 0.3656 0.3899
0.0079 0.3985 0.3985
0.0082 0.507 0.507
0.0068 0.5895 1
0.0279 0.2593 0.3058
0.0082 0.6119 1
0.008 0.251 0.1987
0.0069 0.5895 1
0.0071 0.6119 1
0.0082 0.6062 1
0.0082 0.4166 0.4166
0.0074 0.3379 0.5169
0.0077 0.6006 0.6624
0.0066 0.3211 0.2847
0.0077 0.288 0.3271
0.0082 0.315 0.3087
0.0082 0.3557 0.3557
0.0073 0.6121 1
0.0082 0.2938 0.2536
0.0074 0.3736 0
0.0077 0.2644 0.3824
0.0075 0.5186 1
0.0232 0.2789 0.2857
0.0082 0.3863 1
0.0066 0.3242 0.6565
0.0372 0.2501 0.558
0.0138 0.3202 0.8214
0.0082 0.277 0.3557
0.0069 0.6119 0.5
0.0076 0.2716 0.3095
0.0082 0.5919 1
0.0082 0.6426 1
0.0071 0.2555 0.2021
0.0065 0.3592 0.3844
0.0083 0.292 0.4076
0.0078 0.3515 1
0.0082 0.2627 0.2627
0.0418 0.371 0.371
0.0082 0.2668 0.3049
0.0068 0.5895 1
0.0071 0.4984 0.4984
0.0078 0.459 0.3811
0.0069 0.3724 0.3724
0.0082 0.2603 0.2386
0.0082 0.6062 1
0.0274 0.3942 0.3942
0.0082 0.5339 0.6752
0.007 0.3024 0.4442
0.0082 0.3472 1
0.0074 0.2526 0.3471
0.0073 0.2531 0.2531
0.0067 0.3344 0.5366
0.0082 0.6426 1
0.0082 0.3868 0.5243
0.0074 0.28 0.28
0.0082 0.5919 1
0.0082 0.613 1
0.0083 0.292 0.4076
0.0232 0.2789 0.2857
0.0433 0.6072 0.6067
0.0068 0.3168 0.3168
0.008 0.2594 0.2594
0.0071 0.6119 1
0.0082 0.3264 1
0.0069 0.4773 0
0.0075 0.3242 0.3242
0.0078 0.3515 1
0.0082 0.3791 0.3791
0.0076 0.5919 1
0.0137 0.3174 0.4473
0.0082 0.6119 0.5
0.0069 0.2604 0.2982
0.0067 0.4429 0.4429
0.0082 0.3791 0.3791
0.0082 0.3009 0.3371
0.007 0.519 0.519
0.0075 0.3863 0.5168
0.0071 0.3811 0.3811
0.0077 0.2929 0.6541
0.0151 0.3361 0.9053
0.0082 0.2758 0.4636
0.0082 0.4142 1
0.0074 0.3422 0.5165
0.007 0.6164 0.8282
0.0269 0.2974 0.2974
0.0071 0.2545 0.2342
0.0073 0.5594 1
0.0082 0.3376 0.3792
0.0082 0.6121 1
0.0069 0.2733 0.3193
0.0073 0.6121 1
0.0343 0.3957 0.3912
0.0081 0.6119 0.6634
0.0066 0.3277 1
0.0082 0.6119 1
0.0082 0.2848 0.2848
0.0071 0.254 0.4284
0.0082 0.2859 0.2803
0.0082 0.3863 1
0.007 0.2886 0.5172
0.0074 0.4035 0.4276
0.0071 0.5919 1
0.0068 0.3153 1
0.0077 0.2637 0.3044
0.0217 0.4129 0.4333
0.0072 0.3241 0.3192
0.0082 0.4363 0.4315
0.0082 0.3392 0.3527
0.0074 0.3863 1
0.0077 0.2536 0.2536
0.0066 0.3005 0.2848
0.0144 0.2996 0.3681
0.0077 0.5863 1
0.0082 0.6299 1
0.007 0.2681 0.2664
0.0071 0.2673 0.3848
0.0082 0.3939 0.3881
0.0082 0.2592 0.2949
0.0073 0.2835 0.2835
0.0079 0.6061 0.8414
0.0073 0.3042 1
0.0082 0.3462 0.3462
0.007 0.3121 0.3412
0.0138 0.638 0.9044
0.0082 0.398 0.695
0.0071 0.2536 0.2536
0.0078 0.4154 0
0.0071 0.5724 1
0.0082 0.6184 1
0.0082 0.5545 0.7612
0.0082 0.2919 0.2919
0.0079 0.4353 1
0.0266 0.3566 0.3566
0.0082 0.613 1
0.0082 0.3001 0.8417
0.0319 0.2739 0.2656
0.0082 0.2888 1
0.0067 0.5018 0.5018
0.0075 0.263 0.3009
0.0082 0.5919 1
0.0079 0.3 0.48
0.0082 0.6121 1
0.0074 0.3472 0.6634

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_00060 (Loa Loa (eye worm)), hypothetical protein
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