Detailed information for compound 584418

Basic information

Technical information
  • TDR Targets ID: 584418
  • Name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihy droxy-tetrahydrofuran-2-yl]methyl [(2R,3S,4R, 5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-di hydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
  • MW: 573.411 | Formula: C18H24N9O11P
  • H donors: 7 H acceptors: 12 LogP: -5.51 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 4
  • SMILES: O[C@@H]1[C@@H](COP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2cnc3c2ncnc3N)O)O[C@H]([C@@H]1O)n1cnc(n1)C(=O)N
  • InChi: 1S/C18H24N9O11P/c19-13-8-16(22-3-21-13)26(4-23-8)17-11(30)9(28)6(37-17)1-35-39(33,34)36-2-7-10(29)12(31)18(38-7)27-5-24-15(25-27)14(20)32/h3-7,9-12,17-18,28-31H,1-2H2,(H2,20,32)(H,33,34)(H2,19,21,22)/t6-,7-,9-,10-,11-,12-,17-,18-/m1/s1
  • InChiKey: SUOVLCOMNHUFTD-LCRFBQFRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl [(2R,3S,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(3-aminocarbonyl-1,2,4-triazol-1-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl hydrogen phosphate
  • [(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3S,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
  • adenylyl-(3'-5')-virazole
  • [(2R,3S,4R,5R)-5-(6-amino-9-purinyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl [(2R,3S,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl hydrogen phosphate
  • 80948-57-8
  • 3'-Adenylic acid, 3'-5'-ester with 1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
  • Adenylyl-(3'-5')ribavirin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0854 0.5945
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0091 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0854 0.1412
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0675 0.1081
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0262 0.1329
Mycobacterium tuberculosis Conserved protein 0.0036 0.1375 0.1334
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0675 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1375 0.2375
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0675 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0262 0.0216
Loa Loa (eye worm) hypothetical protein 0.0015 0.0443 0.0651
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0262 0.0216
Echinococcus granulosus cpg binding protein 0.0033 0.1228 0.2615
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0262 0.1904
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0675 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1375 0.4603
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0675 0.1081
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0854 0.5945
Schistosoma mansoni smad1 5 8 and 0.0009 0.0164 0.0167
Brugia malayi Cytochrome P450 family protein 0.0011 0.0262 0.0316
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0194 0.0191
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0262 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0537 0.0492
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0091 0.0044
Echinococcus multilocularis cpg binding protein 0.0033 0.1228 0.2615
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1375 0.2951
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0262 0.1329
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.444 1
Toxoplasma gondii melibiase subfamily protein 0.0105 0.444 1
Onchocerca volvulus 0.0015 0.0443 0.2741
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0537 0.0492
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0116 0.0057
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0434 0.0789
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0164 0.0167
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.115 0.196
Loa Loa (eye worm) beta-lactamase 0.0036 0.1375 0.2375
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0164 0.0134
Brugia malayi Smad1 0.0009 0.0164 0.0134
Loa Loa (eye worm) hypothetical protein 0.0018 0.0581 0.0907
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0581 0.3817
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0262 0.0316
Loa Loa (eye worm) hypothetical protein 0.0018 0.0581 0.0907
Loa Loa (eye worm) hypothetical protein 0.0036 0.1375 0.2375
Schistosoma mansoni cpg binding protein 0.0033 0.1228 0.2615
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1375 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0854 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0116 0.0057
Onchocerca volvulus 0.0024 0.0854 0.5945
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0262 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0537 0.0492
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0164 0.0167
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0854 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0854 0.5945
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.1375 0.1334
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0035 0.1346 0.2885
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0091 0.0663
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.1375 0.2375
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1375 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0262 0.1904
Brugia malayi Kringle domain containing protein 0.0015 0.0443 0.0651
Toxoplasma gondii exonuclease III APE 0.002 0.0675 0.1343
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0091 0.0044
Mycobacterium tuberculosis Conserved protein 0.0036 0.1375 0.1334
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0581 0.5
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0854 0.1412
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.1375 0.1334
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.2693 0.5982
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.444 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0262 0.1329
Echinococcus multilocularis Smad4 0.0009 0.0164 0.0167
Loa Loa (eye worm) hypothetical protein 0.0036 0.1375 0.2375
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0091 0.0663
Onchocerca volvulus 0.0036 0.1375 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0854 0.6213
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0164 0.0167
Mycobacterium ulcerans beta-lactamase 0.0036 0.1375 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0164 0.0167
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.1375 0.1334
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.444 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.2886 0.6426
Mycobacterium tuberculosis Conserved protein 0.0036 0.1375 0.1334
Echinococcus granulosus smad 0.0009 0.0164 0.0167
Mycobacterium ulcerans lipase LipD 0.0036 0.1375 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.1375 0.1334
Schistosoma mansoni smad1 5 8 and 0.0009 0.0164 0.0167
Schistosoma mansoni Smad4 0.0009 0.0164 0.0167
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0262 0.0216
Leishmania major hypothetical protein, conserved 0.0015 0.0443 0.3222
Brugia malayi MH2 domain containing protein 0.0009 0.0164 0.0134
Mycobacterium ulcerans hypothetical protein 0.0036 0.1375 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0091 0.0044
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0116 0.0057
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0091 0.0663
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0581 0.8389
Mycobacterium leprae putative cytochrome p450 0.0011 0.0262 0.1329
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.1375 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1375 0.2951
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0675 0.2105
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0262 0.0392
Toxoplasma gondii ABC1 family protein 0.0036 0.1375 0.2951
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0091 0.0663
Echinococcus granulosus tissue type plasminogen activator 0.0015 0.0443 0.0809
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0675 0.0631
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.02 0.025
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0091 0.0663
Schistosoma mansoni hypothetical protein 0.0011 0.0262 0.0392
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0854 0.0811
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0854 0.6213
Loa Loa (eye worm) hypothetical protein 0.0018 0.0581 0.0907
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.2015 0.356
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0434 0.0789
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0262 0.0392
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0091 0.0044
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0854 0.5945
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0262 0.0216
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0675 0.1343
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0262 0.1329
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.444 1
Brugia malayi cytochrome P450 0.0011 0.0262 0.0316
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0854 0.6213
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0164 0.0167
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0262 0.0316
Loa Loa (eye worm) hypothetical protein 0.0024 0.0854 0.1412
Loa Loa (eye worm) hypothetical protein 0.0036 0.1375 0.2375
Brugia malayi beta-lactamase family protein 0.0036 0.1375 0.2375
Loa Loa (eye worm) cytochrome P450 0.0011 0.0262 0.0316
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.1375 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0854 0.5945
Schistosoma mansoni smad 0.0009 0.0164 0.0167
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0262 0.1329
Brugia malayi Protein kinase domain containing protein 0.0015 0.0443 0.0651
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0262 0.1329
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0262 0.1329
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0581 0.3817
Echinococcus multilocularis smad 0.0009 0.0164 0.0167
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0262 0.1329
Plasmodium vivax hypothetical protein, conserved 0.0036 0.1375 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0262 0.0316
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.2381 0.5265
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0262 0.1329
Brugia malayi MH2 domain containing protein 0.0009 0.0164 0.0134
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0262 0.1329
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0262 0.0216
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0854 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.2886 0.6426
Leishmania major cytochrome p450-like protein 0.0011 0.0262 0.1904
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0854 0.5945
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.1375 0.2951
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0262 0.0216
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0262 0.1329
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0262 0.0216
Brugia malayi MH2 domain containing protein 0.0128 0.5494 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0262 0.0216
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0262 0.1329
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0262 0.0216
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.02 0.025
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.444 1
Toxoplasma gondii kringle domain-containing protein 0.0015 0.0443 0.0809
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0262 0.1329
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0854 0.5945
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0675 0.2105
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1375 0.4603
Leishmania major cytochrome p450-like protein 0.0011 0.0262 0.1904
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0091 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0537 0.0492
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0262 0.0216
Schistosoma mansoni hypothetical protein 0.0015 0.0443 0.0809
Leishmania major cytochrome p450-like protein 0.0011 0.0262 0.1904
Loa Loa (eye worm) hypothetical protein 0.007 0.2886 0.5172
Loa Loa (eye worm) hypothetical protein 0.0036 0.1375 0.2375
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0854 0.1412
Onchocerca volvulus 0.0036 0.1375 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0854 0.1412
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0675 0.1343
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0854 0.5945
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1375 0.4603
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0091 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0262 0.1904
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1375 0.4603
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0262 0.1329
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0262 0.1329
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.1375 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0116 0.0057
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0015 0.0443 0.2741
Echinococcus multilocularis 0.0011 0.0262 0.0392
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0091 0.0044
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0262 0.1329
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.2886 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0262 0.0316
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0675 0.455
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0675 0.5
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0262 0.0216
Brugia malayi MH1 domain containing protein 0.0009 0.0164 0.0134
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0262 0.1329
Loa Loa (eye worm) hypothetical protein 0.0036 0.1375 0.2375
Loa Loa (eye worm) hypothetical protein 0.0018 0.0581 0.0907
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0262 0.0216
Brugia malayi beta-lactamase family protein 0.0036 0.1375 0.2375
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0262 0.0216
Loa Loa (eye worm) TK/ROR protein kinase 0.0015 0.0443 0.0651
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0262 0.1329
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0262 0.0216
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.1375 0.1334
Schistosoma mansoni cytochrome P450 0.0011 0.0262 0.0392
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.5494 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.444 1
Leishmania major hypothetical protein, conserved 0.0036 0.1375 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0581 0.0907
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0675 0.455
Onchocerca volvulus 0.0036 0.1375 1
Brugia malayi MH1 domain containing protein 0.0009 0.0164 0.0134
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0262 0.1329
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0854 0.5945
Mycobacterium leprae conserved hypothetical protein 0.0036 0.1375 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0262 0.0216
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1375 0.4603
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.1375 0.1334
Loa Loa (eye worm) histone methyltransferase 0.001 0.02 0.0201
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0262 0.1904
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0262 0.1329
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0262 0.1329
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.444 1
Echinococcus granulosus Smad4 0.0009 0.0164 0.0167
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0091 0.0019
Brugia malayi CXXC zinc finger family protein 0.0031 0.115 0.196
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0091 0.0044
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0262 0.1329
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0091 0.0663
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0854 0.1412
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0675 0.4911
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.1375 0.1334
Brugia malayi beta-lactamase 0.0036 0.1375 0.2375
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0262 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0262 0.0216
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0091 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0675 0.4911
Schistosoma mansoni cpg binding protein 0.0031 0.115 0.2435
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0091 0.0663
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0262 0.0216
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0116 0.0057
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0675 0.7654
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0854 0.5945
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0262 0.1329
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0675 0.455
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.5494 1
Schistosoma mansoni ap endonuclease 0.002 0.0675 0.1343
Plasmodium falciparum cysteine repeat modular protein 1 0.0015 0.0443 0.6024
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0443 0.3222
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0675 0.4911
Schistosoma mansoni smad1 5 8 and 0.0009 0.0164 0.0167
Brugia malayi Cytochrome P450 family protein 0.005 0.2015 0.356
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0581 0.0537
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0091 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0854 0.0811
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.1375 0.2951
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0262 0.1329
Brugia malayi Melibiase family protein 0.007 0.2886 0.5172
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0262 0.1904
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0164 0.0134
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0262 0.1904
Schistosoma mansoni cpg binding protein 0.0033 0.1228 0.2615
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.1375 0.2375
Trichomonas vaginalis esterase, putative 0.0036 0.1375 0.4603
Loa Loa (eye worm) Smad1 0.0009 0.0164 0.0134
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0262 0.0316
Echinococcus multilocularis tissue type plasminogen activator 0.0015 0.0443 0.0809
Schistosoma mansoni ap endonuclease 0.002 0.0675 0.1343
Mycobacterium leprae Probable lipase LipE 0.0036 0.1375 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0091 0.0044
Onchocerca volvulus 0.0031 0.115 0.825

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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