Detailed information for compound 669602

Basic information

Technical information
  • TDR Targets ID: 669602
  • Name: ethyl 5-acetyl-4-methyl-2-[(2-methylfuran-3-c arbonyl)amino]thiophene-3-carboxylate
  • MW: 335.375 | Formula: C16H17NO5S
  • H donors: 1 H acceptors: 3 LogP: 3.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(sc(c1C)C(=O)C)NC(=O)c1ccoc1C
  • InChi: 1S/C16H17NO5S/c1-5-21-16(20)12-8(2)13(9(3)18)23-15(12)17-14(19)11-6-7-22-10(11)4/h6-7H,5H2,1-4H3,(H,17,19)
  • InChiKey: JSZBUKUHUBLISA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-acetyl-4-methyl-2-[[(2-methyl-3-furyl)-oxomethyl]amino]-3-thiophenecarboxylic acid ethyl ester
  • 5-acetyl-4-methyl-2-[(2-methylfuran-3-carbonyl)amino]thiophene-3-carboxylic acid ethyl ester
  • ethyl 5-ethanoyl-4-methyl-2-[(2-methylfuran-3-yl)carbonylamino]thiophene-3-carboxylate
  • ZINC00476612
  • IVK/9070032

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0089
Leishmania major importin beta-1 subunit, putative 0.0046 0.0437 0.1614
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0484
Brugia malayi Cathepsin L-like precursor 0.0016 0.0072 0.008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0398 0.0444
Trypanosoma cruzi metacaspase 5, putative 0.0146 0.1698 1
Brugia malayi Retinol dehydrogenase 12 0.0019 0.0102 0.0114
Loa Loa (eye worm) RecQ helicase 0.0019 0.0107 0.012
Loa Loa (eye worm) hypothetical protein 0.0042 0.0396 0.0441
Toxoplasma gondii cathepsin CPL 0.0016 0.0072 0.0148
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0226 0.2702 0.2702
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0089
Schistosoma mansoni ferritin light chain 0.0017 0.0074 0.0074
Echinococcus multilocularis caspase 8 0.0146 0.1698 0.1698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0305 0.0305
Echinococcus granulosus geminin 0.0659 0.8115 0.8115
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.0102 0.0089
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0019 0.0102 0.0089
Brugia malayi Muscleblind-like protein 0.0726 0.8965 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Trypanosoma cruzi metacaspase, putative 0.0146 0.1698 1
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0102 0.0102
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0072 0.0183
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0398 0.097
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0398 0.147
Leishmania major cathepsin L-like protease 0.0016 0.0072 0.0266
Loa Loa (eye worm) hypothetical protein 0.0042 0.0396 0.0441
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0107 0.0261
Trypanosoma brucei Metacaspase-4 0.0146 0.1698 1
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0463 0.0463
Brugia malayi hypoxia-induced factor 1 0.0146 0.1701 0.1897
Entamoeba histolytica hypothetical protein 0.0019 0.0102 0.0249
Onchocerca volvulus 0.0019 0.0102 0.0265
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0102 0.0089
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0019 0.0102 0.0465
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0096 0.0355
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0058 0.0599 0.0668
Brugia malayi hypothetical protein 0.0159 0.1854 0.2069
Trichomonas vaginalis set domain proteins, putative 0.0278 0.3345 1
Brugia malayi Pre-SET motif family protein 0.0035 0.0305 0.0341
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0102 0.0107
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0019 0.0102 0.0102
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0107 0.032
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0102 0.0102
Schistosoma mansoni alpha-glucosidase 0.0164 0.1926 0.1926
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0102 0.0602
Onchocerca volvulus 0.0016 0.0072 0.0183
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0146 0.1698 0.1698
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0396 0.2239
Echinococcus granulosus cathepsin l1 0.0011 0.0004 0.0004
Echinococcus multilocularis conserved hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) ctsf protein 0.0016 0.0072 0.008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Echinococcus granulosus apoptotic protease activating factor 1 0.016 0.1873 0.1873
Onchocerca volvulus 0.0026 0.0197 0.0521
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0021 0.0021
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0042 0.0387 0.0797
Toxoplasma gondii carbonyl reductase 1, putative 0.0019 0.0102 0.021
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0065 0.0194
Echinococcus granulosus JmjC domain containing protein 4 0.0042 0.0387 0.0387
Giardia lamblia Reductase, putative 0.0019 0.0102 0.0015
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0019 0.0102 0.0089
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0398 0.0398
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0177 0.2086 0.6345
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0318 0.1769
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0096 0.013
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0396 0.1183
Schistosoma mansoni apoferritin-2 0.0017 0.0074 0.0074
Giardia lamblia PHD finger protein 15 0.0034 0.0295 0.0497
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0227 0.2708 0.2708
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0177 0.2086 0.7703
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3012 0.9004
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0102 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0396 0.1183
Echinococcus multilocularis ferritin 0.0017 0.0074 0.0074
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0266 0.3195 0.3195
Onchocerca volvulus 0.0058 0.0593 0.1592
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0107 0.012
Schistosoma mansoni ran 0.0021 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0099
Trichomonas vaginalis ferritin, putative 0.0017 0.0074 0.0221
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0177 0.2086 0.2086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0396 0.0396
Onchocerca volvulus 0.0019 0.0102 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3012 0.9004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0227 0.2708 1
Plasmodium falciparum steroid dehydrogenase, putative 0.0019 0.0102 0.0578
Brugia malayi jmjC domain containing protein 0.0042 0.0387 0.0432
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Toxoplasma gondii oxidoreductase, putative 0.0019 0.0102 0.021
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0751 0.0838
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Echinococcus multilocularis oxidoreductase 0.0019 0.0102 0.0102
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0146 0.1698 0.3496
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0107 0.0221
Leishmania major dehydrogenase-like protein 0.0019 0.0102 0.0377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Schistosoma mansoni alpha glucosidase 0.0042 0.0398 0.0398
Brugia malayi Dehydrogenases, short chain protein 30 0.0019 0.0102 0.0114
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0396 0.0441
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0023
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0398 0.4857 0.4857
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0096 0.0566
Echinococcus granulosus ferritin 0.0017 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0102 0.0249
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0072 0.0183
Entamoeba histolytica hypothetical protein 0.0046 0.0437 0.1065
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0377
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0398 0.4857 0.4857
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0396 0.0441
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0305 0.0629
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0072 0.0072
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0102 0.0377
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0019 0.0102 0.0249
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Loa Loa (eye worm) hypothetical protein 0.0152 0.1768 0.1972
Brugia malayi Probable ClpP-like protease 0.0152 0.1768 0.1972
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0019 0.0102 0.0306
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0019 0.0102 0.0089
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0227 0.2708 0.3021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0318 0.095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0102 0.0102
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0126 0.0126
Leishmania major cathepsin L-like protease 0.0016 0.0072 0.0266
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0358 0.4353 0.4353
Onchocerca volvulus 0.016 0.1873 0.5052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.012
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0387 0.0432
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.014
Entamoeba histolytica cysteine protease, putative 0.0016 0.0072 0.0175
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0398 0.119
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0152 0.1768 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0102 0.0089
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.021
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0102 0.0377
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0058 0.0593 0.0662
Trypanosoma cruzi metacaspase 5, putative 0.0146 0.1698 1
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0102 0.0089
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0065 0.0194
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0396 0.1015
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0481 0.2741
Schistosoma mansoni carbonyl reductase 0.0019 0.0102 0.0102
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2749 0.2749
Echinococcus multilocularis muscleblind protein 1 0.0726 0.8965 0.8965
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0599 0.737 0.8222
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0099 0.0099
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0102 0.0306
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.3012 0.336
Leishmania major short chain dehydrogenase-like protein 0.0019 0.0102 0.0377
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0102 0.0377
Echinococcus multilocularis importin subunit beta 1 0.0056 0.057 0.057
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0305 0.0305
Onchocerca volvulus 0.0019 0.0102 0.0265
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0019 0.0102 0.0465
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0522 0.2952
Brugia malayi beta-lactamase 0.0042 0.0396 0.0441
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0107 0.0396
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0398 0.119
Onchocerca volvulus 0.0042 0.0396 0.1058
Onchocerca volvulus 0.0019 0.0102 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3012 0.9004
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.0013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0056 0.057 0.0636
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0306 0.0306
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0065 0.0382
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2042 0.6103
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Loa Loa (eye worm) hypothetical protein 0.0726 0.8965 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0367 0.041
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0019 0.0102 0.021
Brugia malayi Dehydrogenases, short chain protein 2 0.0019 0.0102 0.0114
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0102 0.0249
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0197 0.022
Echinococcus granulosus single minded 2 0.0035 0.0306 0.0306
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0072 0.0304
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0021 0.0078
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0019 0.0102 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0305 0.0305
Schistosoma mansoni lamin 0.0026 0.0197 0.0197
Schistosoma mansoni carbonyl reductase 0.0019 0.0102 0.0102
Brugia malayi intermediate filament protein 0.0026 0.0197 0.022
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.057 0.3357
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0318 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0465
Schistosoma mansoni survival motor neuron protein 0.0047 0.0455 0.0455
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0099 0.0099
Leishmania major short chain dehydrogenase, putative 0.0019 0.0102 0.0377
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0099 0.1113 0.3277
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.0102 0.0089
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0102 0.0102
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0295 0.0608
Loa Loa (eye worm) hypothetical protein 0.0042 0.0396 0.0441
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.0102 0.0265
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0107 0.0107
Trichomonas vaginalis ran, putative 0.0021 0.0126 0.0376
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0072 0.0072
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0096 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0019 0.0102 0.0249
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.004 0.0367 0.0367
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0102 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2042 0.6103
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0102 0.0377
Brugia malayi Cathepsin L-like precursor 0.0016 0.0072 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Echinococcus granulosus muscleblind protein 0.0726 0.8965 0.8965
Brugia malayi hypothetical protein 0.0019 0.0102 0.0114
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0072 0.0407
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0396 0.1015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0099 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Echinococcus multilocularis lysine specific demethylase 6a 0.0042 0.0387 0.0387
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0424 0.0473
Schistosoma mansoni ferritin light chain 0.0017 0.0074 0.0074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0177 0.2086 0.7638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Loa Loa (eye worm) STAT protein 0.0128 0.1469 0.1638
Schistosoma mansoni hypothetical protein 0.016 0.1873 0.1873
Onchocerca volvulus 0.0019 0.0102 0.0265
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0042 0.0387 0.0797
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0152 0.1768 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0102 0.0484
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0107 0.0606
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0072 0.0072
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0398 0.119
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0338 0.4103 1
Toxoplasma gondii Alpha-galactosidase 0.0056 0.0573 0.118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0396 0.0396
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0648 0.3738
Echinococcus multilocularis retinol dehydrogenase 13 0.0019 0.0102 0.0102
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0072 0.0407
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0377
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0191 0.2259 0.252
Brugia malayi Cathepsin L-like precursor 0.0016 0.0072 0.008
Leishmania major 3-keto-dihydrosphingosine reductase 0.0019 0.0102 0.0377
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0197 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0063
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0102 0.0107
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0102 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Loa Loa (eye worm) hypothetical protein 0.0726 0.8965 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0295 0.0329
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0019 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Trypanosoma cruzi metacaspase, putative 0.0146 0.1698 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0065 0.0194
Loa Loa (eye worm) cysteine protease 0.0016 0.0072 0.008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 0.2259 0.2259
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.0102 0.0089
Onchocerca volvulus 0.0019 0.0102 0.0265
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.0625
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0398 0.0819
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.008
Leishmania major cathepsin L-like protease 0.0016 0.0072 0.0266
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0387 0.0432
Echinococcus multilocularis cysteine protease 0.0016 0.0072 0.0072
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0367 0.041
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0099 0.1113 0.3277
Loa Loa (eye worm) hypothetical protein 0.0042 0.0387 0.0432
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0096 0.0448
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0019 0.0102 0.0089
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0102 0.0102
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0398 0.119
Schistosoma mansoni ferritin 0.0017 0.0074 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0065 0.0261
Echinococcus multilocularis muscleblind protein 0.0726 0.8965 0.8965
Echinococcus granulosus steroid dehydrogenase 0.0019 0.0102 0.0102
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Brugia malayi STAT protein, DNA binding domain containing protein 0.0128 0.1469 0.1638
Onchocerca volvulus 0.0035 0.0306 0.0814
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0019 0.0102 0.021
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0065 0.0194
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0102 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0102 0.0249
Brugia malayi jmjC domain containing protein 0.0042 0.0387 0.0432
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1931 0.5771
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0019 0.0102 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Plasmodium vivax JmjC domain containing protein 0.0042 0.0387 0.2191
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0044 0.0049
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0295 0.167
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0459 0.0459
Leishmania major protein kinase, putative 0.0012 0.0021 0.0078
Schistosoma mansoni lamin 0.0026 0.0197 0.0197
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0318 0.0318
Brugia malayi oxidoreductase 0.0019 0.0102 0.0114
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0005
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0107 0.0606
Echinococcus multilocularis peptidase Clp (S14 family) 0.0099 0.1113 0.1113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0072 0.008
Leishmania major cathepsin L-like protease 0.0062 0.0648 0.2392
Echinococcus granulosus oxidoreductase 0.0019 0.0102 0.0102
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0065 0.0261
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Mycobacterium ulcerans dehydrogenase/reductase 0.0019 0.0102 0.0107
Brugia malayi Melibiase family protein 0.0266 0.3195 0.3564
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0306 0.0879
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0026 0.0026
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0398 0.119
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0146 0.1698 0.1894
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0295 0.0295
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0096 0.013
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0007 0.004
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0096 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0396 0.2331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Onchocerca volvulus Cell death protein 3 homolog 0.0306 0.3704 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0396 0.0441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0107 0.0107
Brugia malayi hypothetical protein 0.016 0.1873 0.209
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.0625
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0107 0.0107
Brugia malayi Cathepsin L-like precursor 0.0016 0.0072 0.008
Schistosoma mansoni ferritin 0.0017 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1698 0.5075
Echinococcus multilocularis snurportin 1 0.0599 0.737 0.737
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0102 0.0102
Brugia malayi Cathepsin L-like precursor 0.0016 0.0072 0.008
Onchocerca volvulus 0.0012 0.0021 0.0045
Entamoeba histolytica Ran family GTPase 0.0021 0.0126 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1698 0.5075
Schistosoma mansoni ap endonuclease 0.0018 0.0096 0.0096
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0102 0.0306
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Trypanosoma brucei metacaspase MCA2 0.0146 0.1698 1
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3012 0.9004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0021 0.0063
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0102 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0424 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0484
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0593 0.0593
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0102 0.0602
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0019 0.0102 0.0102
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1931 0.5771
Echinococcus granulosus lamin 0.0026 0.0197 0.0197
Plasmodium vivax vivapain-2 0.0016 0.0072 0.0407
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Schistosoma mansoni caspase-7 (C14 family) 0.0306 0.3704 0.3704
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1931 0.5771
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.021
Schistosoma mansoni DNA helicase recq5 0.0019 0.0107 0.0107
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0096 0.0287
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0599 0.0668
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0065 0.0239
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0042 0.0387 0.0387
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0099 0.011
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0007 0.0041
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.0102 0.0265
Entamoeba histolytica hypothetical protein 0.0042 0.0395 0.0964
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Schistosoma mansoni ran 0.0021 0.0126 0.0126
Mycobacterium leprae Probable oxidoreductase 0.0019 0.0102 0.0465
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0019 0.0102 0.0102
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0395 0.0395
Schistosoma mansoni caspase-3 (C14 family) 0.0358 0.4353 0.4353
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0019 0.0102 0.0089
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0065 0.0194
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0026 0.0026
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Trichomonas vaginalis esterase, putative 0.0042 0.0396 0.1183
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Brugia malayi jmjC domain containing protein 0.0042 0.0387 0.0432
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0102 0.0306
Entamoeba histolytica hypothetical protein 0.0042 0.0395 0.0964
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0072 0.0215
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0021 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0387 0.0432
Onchocerca volvulus Alhambra homolog 0.0034 0.0295 0.0786
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0318 0.0354
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0065 0.0194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0424 0.0473
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0377
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Leishmania major cathepsin L-like protease 0.0016 0.0072 0.0266
Leishmania major protein kinase, putative 0.0012 0.0021 0.0078
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0019 0.0102 0.0166
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0102 0.0377
Plasmodium falciparum importin beta, putative 0.0056 0.057 0.3224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0424 0.0424
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0295 0.0295
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1698 0.5075
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Schistosoma mansoni aldehyde dehydrogenase 0.0177 0.2086 0.2086
Loa Loa (eye worm) hypothetical protein 0.0306 0.3704 0.4132
Schistosoma mansoni hypothetical protein 0.0034 0.0295 0.0295
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0065 0.0072
Brugia malayi Cell death protein 3 precursor 0.0306 0.3704 0.4132
Trypanosoma cruzi metacaspase, putative 0.0146 0.1698 1
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3012 0.9004
Echinococcus multilocularis lamin dm0 0.0026 0.0197 0.0197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0107 0.012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0072 0.0175
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Leishmania major cathepsin L-like protease 0.0062 0.0648 0.2392
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0019 0.0102 0.0107
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0227 0.2708 1
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0306 0.0341
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0463 0.0463
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0102 0.0102
Onchocerca volvulus 0.0016 0.0072 0.0183
Onchocerca volvulus Sepiapterin reductase homolog 0.0019 0.0102 0.0265
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0007 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0648 0.3738
Schistosoma mansoni phosphatidylserine receptor 0.0042 0.0387 0.0387
Schistosoma mansoni hypothetical protein 0.0659 0.8115 0.8115
Giardia lamblia Short-chain dehydrogenase, putative 0.0019 0.0102 0.0015
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.021
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0099 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0484
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0152 0.1768 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0305 0.0305
Onchocerca volvulus 0.0016 0.0072 0.0183
Echinococcus multilocularis caspase 3 0.0212 0.2522 0.2522
Loa Loa (eye worm) fibroinase 0.0016 0.0072 0.008
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0052 0.0522 0.2952
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0072
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0019 0.0102 0.0089
Mycobacterium tuberculosis Conserved protein 0.0042 0.0396 0.1015
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0099
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0318 0.0318
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0146 0.1698 0.3496
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0072 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0019 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0065 0.0164
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0102 0.0306
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0318 0.0553
Mycobacterium leprae Probable lipase LipE 0.0042 0.0396 0.2145
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0318 0.0318
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0396 0.1015
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0102 0.0102
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0021 0.0063
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.057 0.3357
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0004 0.001
Echinococcus granulosus intermediate filament protein 0.0026 0.0197 0.0197
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.1931 0.5206
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0266 0.3195 0.9549
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0042 0.0387 0.2185
Plasmodium falciparum metacaspase 1 0.0146 0.1698 0.9604
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0102 0.0377
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0023
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0065 0.0158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0023 0.0023
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0102 0.0306
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0387 0.0432
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0107 0.0221
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0102 0.0484
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0146 0.1698 0.3496
Trypanosoma cruzi metacaspase, putative 0.0146 0.1698 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0522 0.2644
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0019 0.0102 0.0114
Onchocerca volvulus 0.0016 0.0072 0.0183
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0099
Schistosoma mansoni jumonji domain containing protein 0.0203 0.2414 0.2414
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0398 0.119
Onchocerca volvulus 0.0035 0.0305 0.0814
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0398 0.119
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0396 0.1015
Onchocerca volvulus 0.0019 0.0102 0.0265
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.014
Schistosoma mansoni single-minded 0.0047 0.0459 0.0459
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0208 0.2473 0.2758
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0072 0.0407
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.2923 0.3261
Plasmodium falciparum phd finger protein, putative 0.0034 0.0295 0.167
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0102 0.0484
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0099
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0096 0.0069
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0398 0.0398
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0152 0.1768 1
Onchocerca volvulus 0.0019 0.0102 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0102 0.0377
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0395 0.0395
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0396 0.0396
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.021
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0065 0.0194
Loa Loa (eye worm) hypothetical protein 0.0035 0.0305 0.0341
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0089
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0074 0.0304
Brugia malayi PAS domain containing protein 0.0047 0.0459 0.0513
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0484
Plasmodium falciparum JmjC domain-containing protein, putative 0.0042 0.0387 0.2191
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0398 0.119
Entamoeba histolytica short chain dehydrogenase family protein 0.0019 0.0102 0.0249
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0226 0.2702 0.2702
Leishmania major cathepsin L-like protease 0.0062 0.0648 0.2392
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0021 0.0021
Echinococcus multilocularis lysine specific demethylase 5A 0.0156 0.1818 0.1818
Schistosoma mansoni aldehyde dehydrogenase 0.0177 0.2086 0.2086
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0107 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0396 0.2235
Brugia malayi cathepsin L-like precursor 0.0011 0.0004 0.0005
Echinococcus granulosus peptidase Clp S14 family 0.0099 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.023 0.2749 0.3066
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0019 0.0102 0.0602
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0358 0.4353 0.4353
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.1768 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0396 0.1015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Loa Loa (eye worm) dehydrogenase 0.0019 0.0102 0.0114
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0023 0.0026
Brugia malayi jmjC domain containing protein 0.0042 0.0387 0.0432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.0013
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0021 0.0023
Onchocerca volvulus 0.0019 0.0102 0.0265
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0005
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0042 0.0387 0.2281
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0019 0.0102 0.0107
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0072 0.0072
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0377
Echinococcus granulosus WW domain containing oxidoreductase 0.0019 0.0102 0.0102
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0096 0.0448
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0177 0.2086 0.2086
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0102 0.0306
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0107 0.032
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.1768 0.6431
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0396 0.0441
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0021 0.0063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Echinococcus multilocularis caspase 0.0358 0.4353 0.4353
Plasmodium vivax hypothetical protein, conserved 0.0146 0.1698 0.9604
Schistosoma mansoni jumonji/arid domain-containing protein 0.0156 0.1818 0.1818
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0396 0.1221
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0102 0.0484
Echinococcus multilocularis musashi 0.0026 0.0197 0.0197
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Leishmania major short chain dehydrogenase, putative 0.0019 0.0102 0.0377
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0074
Brugia malayi beta-lactamase family protein 0.0042 0.0396 0.0441
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0396 0.1183
Onchocerca volvulus 0.0016 0.0072 0.0183
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0042 0.0387 0.0387
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0102 0.0484
Brugia malayi Glycosyl hydrolases family 31 protein 0.0191 0.2259 0.252
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0102 0.0102
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0396 0.2145
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0096 0.0084
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0396 0.1221
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0295 0.0329
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0455 0.0507
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0107 0.0631
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1931 0.5771
Plasmodium vivax vivapain-2 0.0016 0.0072 0.0407
Mycobacterium tuberculosis Conserved protein 0.0042 0.0396 0.1015
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0227 0.2708 0.2708
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0065 0.0194
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Trypanosoma brucei glucosidase, putative 0.0042 0.0398 0.2344
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1931 0.5771
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0102 0.0484
Schistosoma mansoni DNA helicase recq1 0.0019 0.0107 0.0107
Toxoplasma gondii oxidoreductase, putative 0.0019 0.0102 0.021
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.1768 1
Echinococcus multilocularis lamin 0.0026 0.0197 0.0197
Onchocerca volvulus 0.0016 0.0072 0.0183
Brugia malayi AF-10 protein 0.0011 0.0007 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0126 0.0711
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0318 0.095
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0126 0.0126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0396 0.1015
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0019 0.0102 0.0602
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0396 0.1015
Plasmodium vivax SET domain protein, putative 0.0035 0.0305 0.1727
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0096 0.0234
Schistosoma mansoni protein phosphatase 2C 0.0042 0.0387 0.0387
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0396 0.0396
Echinococcus multilocularis JmjC domain containing protein 4 0.0042 0.0387 0.0387
Toxoplasma gondii exonuclease III APE 0.0018 0.0096 0.0198
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0398 0.4857 0.4857
Brugia malayi Importin beta-1 subunit 0.0056 0.057 0.0636
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0398 0.2248
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Schistosoma mansoni hypothetical protein 0.0047 0.0455 0.0455
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0019 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0072 0.0215
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0396 0.1015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0424 0.0424
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0437 0.2481
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0019 0.0102 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Echinococcus multilocularis peregrin 0.0034 0.0295 0.0295
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0019 0.0102 0.0265
Onchocerca volvulus 0.0047 0.0455 0.1218
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Mycobacterium ulcerans lipase LipD 0.0042 0.0396 0.1221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0102 0.0107
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0072 0.0072
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0019 0.0102 0.0465
Toxoplasma gondii hypothetical protein 0.0052 0.0522 0.1075
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0266 0.3195 0.3195
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0227 0.2708 0.2708
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0102 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0318 0.095
Brugia malayi Pre-SET motif family protein 0.0244 0.2923 0.3261
Plasmodium vivax importin-beta 2, putative 0.0056 0.057 0.3224
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0019 0.0102 0.0306
Plasmodium vivax steroid dehydrogenase, putative 0.0019 0.0102 0.0578
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0102 0.0484
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0318 0.0318
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0021 0.0063
Echinococcus multilocularis tumor protein p63 0.0396 0.4829 0.4829
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0021 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0424 0.0424
Mycobacterium ulcerans oxidoreductase 0.0019 0.0102 0.0107
Brugia malayi beta-lactamase family protein 0.0042 0.0396 0.0441
Schistosoma mansoni retinal dehydrogenase 0.0019 0.0102 0.0102
Brugia malayi hypothetical protein 0.023 0.2749 0.3066
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0295 0.0295
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0102 0.0306
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0096 0.0544
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0398 0.4857 0.4857
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0197 0.022
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Onchocerca volvulus 0.0042 0.0396 0.1058
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0102 0.0089
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0102 0.0102
Entamoeba histolytica short chain dehydrogenase family protein 0.0019 0.0102 0.0249
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Echinococcus granulosus lysine specific demethylase 6a 0.0042 0.0387 0.0387
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0398 0.097
Echinococcus granulosus cathepsin l1 0.0016 0.0072 0.0072
Brugia malayi dehydrogenases, short chain protein 9 0.0019 0.0102 0.0114
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1701 0.1897
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1698 0.5075
Echinococcus granulosus hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma brucei metacaspase 0.0146 0.1698 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0102 0.0484
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0072 0.008
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0019 0.0102 0.0107
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.1768 0.6431
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0023
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 0.2259 0.2259
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0227 0.2708 1
Brugia malayi PHD-finger family protein 0.0034 0.0295 0.0329
Brugia malayi PHD-finger family protein 0.0011 0.0007 0.0008
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0102 0.0249
Echinococcus granulosus expressed protein 0.0017 0.0074 0.0074
Echinococcus granulosus caspase 2 0.0306 0.3704 0.3704
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0019 0.0102 0.0089
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0102 0.0484
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.0102 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0305 0.0305
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0102 0.0484
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1931 0.5771
Schistosoma mansoni importin beta-1 0.0056 0.057 0.057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Echinococcus granulosus caspase 0.0358 0.4353 0.4353
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0305 0.0305
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0107 0.0107
Echinococcus multilocularis jumonji domain containing 1A 0.0042 0.0387 0.0387
Brugia malayi Cathepsin L-like precursor 0.0016 0.0072 0.008
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0295 0.0608
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0019 0.0102 0.0102
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0107 0.032
Echinococcus multilocularis GPCR, family 2 0.0018 0.0099 0.0099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0599 0.0668
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0107 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0648 0.3738
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.022
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Onchocerca volvulus 0.0016 0.0072 0.0183
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0398 0.119
Echinococcus multilocularis cysteine protease 0.0016 0.0072 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0177 0.2086 0.7638
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Toxoplasma gondii aldehyde dehydrogenase 0.0177 0.2086 0.4294
Echinococcus granulosus caspase 8 0.0146 0.1698 0.1698
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0398 0.4857 0.4857
Echinococcus granulosus phd:f box containing protein 0.0042 0.0387 0.0387
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0019 0.0102 0.0114
Echinococcus granulosus hypothetical protein 0.0019 0.0102 0.0102
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0102 0.0107
Echinococcus granulosus jumonji domain containing 1A 0.0042 0.0387 0.0387
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.0873 0.2129
Loa Loa (eye worm) jmjC domain-containing protein 0.0156 0.1818 0.2028
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1698 0.5075
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0102 0.0102
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0072 0.0175
Toxoplasma gondii ABC1 family protein 0.0042 0.0396 0.0815
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0396 0.1183
Schistosoma mansoni hypothetical protein 0.0659 0.8115 0.8115
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Schistosoma mansoni jumonji domain containing protein 0.0042 0.0387 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Echinococcus granulosus tumor protein p63 0.0396 0.4829 0.4829
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0318 0.0318
Brugia malayi hypothetical protein 0.0019 0.0102 0.0114
Schistosoma mansoni ferritin 0.0017 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0159 0.1854 0.2069
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.3245 1
Onchocerca volvulus 0.0019 0.0102 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Trypanosoma brucei metacaspase 5, putative 0.0146 0.1698 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.1768 0.364
Echinococcus multilocularis phd:f box containing protein 0.0042 0.0387 0.0387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0424 0.0424
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0395 0.0395
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0102 0.0089
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0019 0.0102 0.021
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0019 0.0102 0.0089
Plasmodium vivax metacaspase 1, putative 0.0146 0.1698 0.9604
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0213
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0004 0.0004
Echinococcus multilocularis expressed protein 0.0017 0.0074 0.0074
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0398 0.0444
Loa Loa (eye worm) hypothetical protein 0.0089 0.0983 0.1097
Echinococcus granulosus bloom syndrome protein 0.0019 0.0107 0.0107
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.057 0.1173
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0042 0.0387 0.0387
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0102 0.0484
Loa Loa (eye worm) hypothetical protein 0.008 0.0873 0.0974
Echinococcus granulosus lysosomal alpha glucosidase 0.0191 0.2259 0.2259
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3012 0.9004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0029
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.058 0.3334
Leishmania major metacaspase, putative 0.0146 0.1698 0.627
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0102 0.0114
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0102 0.0578
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0072 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0063
Schistosoma mansoni ferritin 0.0017 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0599 0.737 0.737
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1698 0.5075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0318 0.0318
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0099 0.011
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0072 0.0072
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0318 0.1769
Toxoplasma gondii melibiase subfamily protein 0.0398 0.4857 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0008
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0107 0.0028
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0398 0.4857 0.4857
Echinococcus granulosus importin subunit beta 1 0.0056 0.057 0.057
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0484
Schistosoma mansoni phd/f-box containing protein 0.0042 0.0387 0.0387
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Mycobacterium tuberculosis Probable dehydrogenase 0.0019 0.0102 0.0089
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0019 0.0102 0.0089
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0318 0.1871
Trypanosoma brucei oxidoreductase-like protein 0.0019 0.0102 0.0602
Echinococcus granulosus GPCR family 2 0.0018 0.0099 0.0099
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0099 0.1113 0.6251
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Schistosoma mansoni caspase-7 (C14 family) 0.0358 0.4353 0.4353
Plasmodium falciparum metacaspase-like protein 0.0146 0.1698 0.9604
Schistosoma mansoni peptidase Clp (S14 family) 0.0152 0.1768 0.1768
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0599 0.0668
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0377
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0089
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0021 0.0063
Leishmania major GTP-binding protein, putative 0.0021 0.0126 0.0464
Leishmania major hypothetical protein, conserved 0.0042 0.0387 0.143
Echinococcus granulosus peregrin 0.0034 0.0295 0.0295
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0072 0.0183
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0096 0.1072 0.2613
Schistosoma mansoni alpha-glucosidase 0.0164 0.1926 0.1926
Brugia malayi dehydrogenases, short chain protein 2 0.0019 0.0102 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0648 0.3815
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0437 0.1306
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0437 0.1306
Loa Loa (eye worm) hypothetical protein 0.0146 0.1698 0.1894
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0318 0.0318
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1698 0.5075
Mycobacterium ulcerans hypothetical protein 0.0042 0.0396 0.1221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0102 0.0602
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0102 0.0484
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0096 0.0287
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0102 0.0102
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Onchocerca volvulus 0.0278 0.3345 0.903
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0072 0.008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0305 0.0305
Schistosoma mansoni apoferritin-2 0.0017 0.0074 0.0074
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0019 0.0102 0.0102
Mycobacterium ulcerans beta-lactamase 0.0042 0.0396 0.1221
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0019 0.0102 0.0602
Onchocerca volvulus 0.0019 0.0102 0.0265
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0227 0.2708 0.8306
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Brugia malayi RNA, U transporter 1 0.016 0.1866 0.2081
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0102 0.0484
Loa Loa (eye worm) hypothetical protein 0.0036 0.0318 0.0354
Onchocerca volvulus 0.0026 0.0197 0.0521
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0711
Entamoeba histolytica hypothetical protein 0.0042 0.0395 0.0964
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0089
Giardia lamblia Hypothetical protein 0.0019 0.0102 0.0015
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.3012 0.336
Schistosoma mansoni jumonji/arid domain-containing protein 0.0156 0.1818 0.1818
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0102 0.0102
Entamoeba histolytica hypothetical protein 0.0042 0.0395 0.0964
Entamoeba histolytica hypothetical protein 0.0096 0.1072 0.2613
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0099 0.0099
Loa Loa (eye worm) beta-lactamase 0.0042 0.0396 0.0441
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0021 0.0063
Loa Loa (eye worm) hypothetical protein 0.0042 0.0396 0.0441
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1931 0.5771
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0318 0.1173
Mycobacterium ulcerans dehydrogenase 0.0019 0.0102 0.0107
Brugia malayi Bromodomain containing protein 0.0034 0.0295 0.0329
Onchocerca volvulus 0.0019 0.0102 0.0265
Echinococcus granulosus caspase 3 0.0212 0.2522 0.2522
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0102 0.0102
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0019 0.0102 0.0602
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0004 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Onchocerca volvulus 0.0019 0.0102 0.0265
Onchocerca volvulus 0.011 0.1251 0.3369
Echinococcus multilocularis geminin 0.0659 0.8115 0.8115
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0096 0.0544
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0465
Onchocerca volvulus 0.0042 0.0396 0.1058
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0056 0.0573 0.0573
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0396 0.2235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0072 0.0215
Schistosoma mansoni hypothetical protein 0.0042 0.0395 0.0395
Schistosoma mansoni microtubule-associated protein tau 0.0809 1 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0019 0.0102 0.0578
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2749 0.2749
Leishmania major oxidoreductase-like protein 0.0019 0.0102 0.0377
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0019 0.0102 0.0102
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0021 0.0021
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0126 0.0259
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0152 0.1768 0.1768
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0007 0.004
Loa Loa (eye worm) oxidoreductase 0.0019 0.0102 0.0114
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0102 0.0089
Schistosoma mansoni intermediate filament proteins 0.0026 0.0197 0.0197
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0318 0.0774
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0102 0.0107
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0107 0.012
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0019 0.0102 0.0484
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.016 0.1873 0.209
Echinococcus multilocularis caspase 2 0.0306 0.3704 0.3704
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0007 0.0041
Leishmania major cathepsin L-like protease 0.0016 0.0072 0.0266
Trypanosoma brucei metacaspase MCA3 0.0146 0.1698 1
Mycobacterium ulcerans oxidoreductase 0.0019 0.0102 0.0107
Brugia malayi jmjC domain containing protein 0.0226 0.2702 0.3014
Giardia lamblia DNA repair protein RAD52 0.0338 0.4103 1
Loa Loa (eye worm) hypothetical protein 0.0266 0.3195 0.3564
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Schistosoma mansoni carbonyl reductase 0.0019 0.0102 0.0102
Trichomonas vaginalis steroid dehydrogenase, putative 0.0019 0.0102 0.0306
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0102 0.0107
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0044 0.0049
Leishmania major pteridine reductase 1 0.0019 0.0102 0.0377
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.0741
Echinococcus granulosus snurportin 1 0.0599 0.737 0.737
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0072 0.0266
Schistosoma mansoni ap endonuclease 0.0018 0.0096 0.0096
Brugia malayi hypothetical protein 0.0042 0.0395 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0484
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0102 0.0602
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0052 0.0522 0.2868
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0019 0.0102 0.0102
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0042 0.0387 0.2185
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0019 0.0102 0.0602
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0019 0.0102 0.0114
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0102 0.0602
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0398 0.4857 0.4857
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0007 0.0014
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.1768 0.364
Leishmania major hypothetical protein, conserved 0.0042 0.0396 0.1462
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0102 0.0578
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0437 0.1306
Mycobacterium ulcerans aldehyde dehydrogenase 0.0177 0.2086 0.7638
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0102 0.0249
Echinococcus multilocularis apoptotic protease activating factor 1 0.016 0.1873 0.1873
Mycobacterium ulcerans carveol-like dehydrogenase 0.0019 0.0102 0.0107
Echinococcus multilocularis microtubule associated protein 2 0.0809 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0156 0.1818 0.1818
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0648 0.3738
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0102 0.0306
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0152 0.1768 0.1768
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0102 0.0377
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0096 0.0096
Echinococcus granulosus lamin dm0 0.0026 0.0197 0.0197
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0152 0.1768 1
Brugia malayi jmjC domain containing protein 0.0156 0.1818 0.2028
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0398 0.2248
Loa Loa (eye worm) dehydrogenase 0.0019 0.0102 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0396 0.1183
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0107 0.0514
Mycobacterium ulcerans short-chain type oxidoreductase 0.0019 0.0102 0.0107
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.0873 0.2129

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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