Detailed information for compound 18311

Basic information

Technical information
  • TDR Targets ID: 18311
  • Name: 2-chloroethyl 2,3,4,5,6-pentachlorobenzenesul fonate
  • MW: 392.899 | Formula: C8H4Cl6O3S
  • H donors: 0 H acceptors: 2 LogP: 4.94 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCOS(=O)(=O)c1c(Cl)c(Cl)c(c(c1Cl)Cl)Cl
  • InChi: 1S/C8H4Cl6O3S/c9-1-2-17-18(15,16)8-6(13)4(11)3(10)5(12)7(8)14/h1-2H2
  • InChiKey: JLLONYIVVFQZQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3,4,5,6-pentachlorobenzenesulfonic acid 2-chloroethyl ester
  • 85650-13-1
  • NSC345398

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0028 0.0179 0.0432
Leishmania major hypothetical protein, conserved 0.0023 0.0106 0.0243
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0598 0.8604 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.011 0.1385 0.1607
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0046 0.0107
Brugia malayi excitatory GABA receptor EXP-1A 0.0021 0.0076 0.0121
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0021 0.0076 0.0074
Brugia malayi Bromodomain containing protein 0.0075 0.0876 0.1442
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0069 0.011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0028 0.0179 0.0291
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0028 0.0179 0.0432
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0106 0.1329 0.31
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0553 0.0551
Schistosoma mansoni sulfide quinone reductase 0.0028 0.0179 0.0176
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0076 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0106 0.1329 0.31
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0046 0.0107
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0028 0.0179 0.0205
Leishmania major hypothetical protein, conserved 0.0028 0.0179 0.0412
Loa Loa (eye worm) hypothetical protein 0.0041 0.0367 0.0603
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0028 0.0179 0.0412
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0076 0.0121
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0076 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0046 0.0063
Echinococcus multilocularis glycine receptor subunit beta 0.0021 0.0076 0.0074
Echinococcus granulosus zinc finger protein 0.002 0.0053 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0106 0.0243
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0106 0.1329 0.1327
Trypanosoma brucei Silent information regulator 2 related protein 1 0.011 0.1385 0.3234
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0553 0.1288
Treponema pallidum fructose-bisphosphate aldolase 0.0598 0.8604 1
Loa Loa (eye worm) glutathione reductase 0.0305 0.4282 0.7066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0021 0.0031
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0296 0.0294
Plasmodium falciparum phd finger protein, putative 0.0029 0.0195 0.0452
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.035 0.0813
Trypanosoma brucei unspecified product 0.0033 0.0256 0.0597
Brugia malayi Thioredoxin reductase 0.0305 0.4282 0.7066
Loa Loa (eye worm) POT family protein 0.0202 0.2753 0.4541
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0311 0.0757
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0106 0.1329 0.3252
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0952 0.0949
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0021 0.0031
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0028 0.0179 0.0432
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0021 0.0076 0.0074
Echinococcus granulosus chromatin regulatory protein sir2 0.011 0.1385 0.1383
Onchocerca volvulus Huntingtin homolog 0.0128 0.1652 0.23
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0553 0.0551
Toxoplasma gondii selenide, water dikinase 0.0028 0.0179 0.0412
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1226 0.1423
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0046 0.0107
Echinococcus granulosus nAChR subunit 0.0021 0.0076 0.0074
Giardia lamblia Hypothetical protein 0.011 0.1385 0.1607
Schistosoma mansoni bromodomain containing protein 0.0063 0.0702 0.07
Schistosoma mansoni hypothetical protein 0.0021 0.0069 0.0067
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0097 0.0222
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.1179 0.1177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0021 0.0019
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0553 0.1288
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0553 0.0551
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.011 0.1385 0.323
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0021 0.0076 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0207 0.0484
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0031
Echinococcus granulosus peregrin 0.0032 0.0231 0.0228
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0699 0.1708
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0064 0.015
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0028 0.0179 0.0176
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0046 0.0063
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0106 0.1329 0.31
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.035 0.0813
Giardia lamblia DINP protein human, muc B family 0.002 0.0064 0.0072
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0046 0.0063
Mycobacterium ulcerans NADH dehydrogenase 0.0028 0.0179 0.0432
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0028 0.0179 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.8604 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0028 0.0179 0.0176
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0028 0.0179 0.0412
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0046 0.0063
Plasmodium vivax SET domain protein, putative 0.0061 0.0666 0.1551
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0106 0.1329 0.3252
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0553 0.1288
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0021 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0028 0.0179 0.0192
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0028 0.0179 0.0412
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0076 0.0074
Trichomonas vaginalis set domain proteins, putative 0.0484 0.6929 0.8052
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0021 0.0076 0.0121
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0028 0.0179 0.0253
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0578 0.0951
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0649 0.0647
Leishmania major hypothetical protein, conserved 0.0028 0.0179 0.0412
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0046 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Mycobacterium ulcerans DNA polymerase IV 0.004 0.035 0.0852
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0076 0.0074
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0076 0.0121
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0046 0.0072
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0028 0.0179 0.0176
Loa Loa (eye worm) ACC-1 protein 0.0021 0.0076 0.0121
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0666 0.1551
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0046 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0106 0.1329 0.3104
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0021 0.0031
Echinococcus granulosus dna polymerase kappa 0.004 0.035 0.0348
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0028 0.0179 0.0205
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0491 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0097 0.0233
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0553 0.1288
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0021 0.0076 0.0074
Brugia malayi Pre-SET motif family protein 0.0425 0.6059 1
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0179 0.0412
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0699 0.0697
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0078 0.0913 0.1504
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0076 0.0121
Schistosoma mansoni chromatin regulatory protein sir2 0.011 0.1385 0.1383
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0028 0.0179 0.0412
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0553 0.1292
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0106 0.1329 0.31
Onchocerca volvulus 0.0032 0.0235 0.0232
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0021 0.0076 0.0121
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0046 0.0107
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0028 0.0179 0.0432
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0076 0.0121
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0952 0.0949
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0319
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0021 0.0076 0.0074
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0106 0.1329 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0046 0.0063
Trichomonas vaginalis glutamate synthase, putative 0.0028 0.0179 0.0205
Plasmodium vivax thioredoxin reductase, putative 0.0305 0.4282 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0311 0.0726
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0021 0.0076 0.0121
Treponema pallidum oxidoreductase 0.0028 0.0179 0.0096
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0046 0.0063
Leishmania major cytochrome p450-like protein 0.0019 0.0046 0.0102
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0411 0.0475
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0046 0.0107
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0365 0.0422
Echinococcus granulosus chromobox protein 1 0.0073 0.0837 0.0835
Brugia malayi POT family protein 0.0202 0.2753 0.4541
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1226 0.1423
Echinococcus multilocularis zinc finger protein 0.002 0.0053 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0553 0.0641
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0028 0.0179 0.0205
Trypanosoma brucei polo-like protein kinase 0.0099 0.1226 0.2864
Brugia malayi jmjC domain containing protein 0.0037 0.0315 0.0516
Onchocerca volvulus 0.008 0.0952 0.1278
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0076 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0553 0.1288
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0046 0.0102
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0311 0.0721
Brugia malayi jmjC domain containing protein 0.0096 0.1179 0.1944
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0076 0.0074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0106 0.1329 0.3252
Trypanosoma brucei SIR2-like protein 4, putative 0.0016 0.0002 0.0005
Brugia malayi PHD-finger family protein 0.0025 0.0133 0.0215
Toxoplasma gondii NADPH-glutathione reductase 0.0106 0.1329 0.31
Schistosoma mansoni glutamate synthase 0.0028 0.0179 0.0176
Trypanosoma cruzi NADH dehydrogenase, putative 0.0028 0.0179 0.0412
Schistosoma mansoni glutamate synthase 0.0028 0.0179 0.0176
Echinococcus multilocularis glutamate synthase 0.0028 0.0179 0.0176
Entamoeba histolytica thioredoxin reductase, putative 0.0028 0.0179 0.0205
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0046 0.0107
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0699 0.0697
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0097 0.0136
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0046 0.0063
Loa Loa (eye worm) hypothetical protein 0.003 0.0207 0.0339
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0842 0.084
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0021 0.0019
Mycobacterium tuberculosis Probable dehydrogenase 0.0409 0.5815 0.8348
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0106 0.1329 0.3104
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0553 0.0641
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0097 0.0227
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0028 0.0179 0.0412
Mycobacterium ulcerans ferredoxin reductase 0.0028 0.0179 0.0432
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1226 0.2021
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0553 0.0551
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0666 0.0664
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0046 0.0063
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0028 0.0179 0.0412
Treponema pallidum thioredoxin reductase (trxB) 0.0028 0.0179 0.0096
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1226 0.1679
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0311 0.1735
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0046 0.0107
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0046 0.0102
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0028 0.0179 0.0205
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0028 0.0179 0.0176
Echinococcus multilocularis thioredoxin glutathione reductase 0.0306 0.4297 0.4296
Loa Loa (eye worm) hypothetical protein 0.0071 0.0812 0.1337
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0699 0.1628
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0021 0.0076 0.0121
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0195 0.0193
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0046 0.0107
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0553 0.1288
Echinococcus granulosus glutamate synthase 0.0028 0.0179 0.0176
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0028 0.0179 0.0432
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.035 0.0818
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0046 0.0107
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0028 0.0179 0.0412
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0195 0.0452
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0021 0.0076 0.0074
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0021 0.0076 0.0074
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0553 0.0641
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0097 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Onchocerca volvulus 0.0073 0.0842 0.1118
Giardia lamblia Glutamate synthase 0.0028 0.0179 0.0205
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0553 0.091
Brugia malayi Cation transporter family protein 0.0021 0.0076 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0179 0.0417
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0046 0.0107
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0097 0.0222
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0021 0.0076 0.0074
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0028 0.0179 0.0412
Brugia malayi Cytochrome P450 family protein 0.0039 0.0337 0.0553
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0028 0.0179 0.0176
Schistosoma mansoni inositol monophosphatase 0.0037 0.0311 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1226 0.1423
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1226 0.1423
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.035 0.0818
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0106 0.1329 0.1327
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0046 0.0072
Brugia malayi glutathione reductase 0.0305 0.4282 0.7066
Treponema pallidum NADH oxidase 0.0106 0.1329 0.1448
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0028 0.0179 0.0417
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1226 0.286
Leishmania major trypanothione reductase 0.0305 0.4282 1
Brugia malayi hypothetical protein 0.0128 0.1652 0.2723
Brugia malayi Inositol-1 0.0037 0.0311 0.051
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0076 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0046 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0337 0.0553
Loa Loa (eye worm) hypothetical protein 0.0128 0.1652 0.2723
Trypanosoma brucei NADH dehydrogenase 0.0028 0.0179 0.0417
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Entamoeba histolytica disulphide oxidoreductase, putative 0.0028 0.0179 0.0205
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0028 0.0179 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0189 0.0217
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0195 0.0193
Mycobacterium ulcerans DNA polymerase IV 0.004 0.035 0.0852
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0195 0.0319
Trichomonas vaginalis mercuric reductase, putative 0.0106 0.1329 0.1542
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0021 0.0076 0.0074
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0028 0.0179 0.0176
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0021 0.0076 0.0074
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0919 0.0917
Schistosoma mansoni zinc finger protein 0.002 0.0053 0.0051
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0028 0.0179 0.0291
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0292 0.4082 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0021 0.0076 0.0074
Leishmania major silent information regulator 2, putative 0.011 0.1385 0.323
Schistosoma mansoni chromobox protein 0.0073 0.0837 0.0835
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0315 0.0313
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0046 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0919 0.0917
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0311 0.0721
Brugia malayi transcriptional regulator, Sir2 family protein 0.011 0.1385 0.2283
Plasmodium falciparum ferrodoxin reductase-like protein 0.0028 0.0179 0.0412
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0411 0.0475
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0311 0.0359
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.032 0.0525
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0076 0.0074
Echinococcus multilocularis chromobox protein 1 0.0073 0.0837 0.0835
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0106 0.1329 0.219
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.011 0.1385 0.1383
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0021 0.0076 0.0074
Brugia malayi Cytochrome P450 family protein 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0952 0.0949
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0311 0.0721
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0409 0.5815 0.8348
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0553 0.0551
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0021 0.0019
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0106 0.1329 0.31
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0046 0.0107
Loa Loa (eye worm) hypothetical protein 0.008 0.0952 0.1567
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0553 0.0641
Echinococcus multilocularis glycine receptor subunit beta 0.0021 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0332 0.0545
Brugia malayi Cytochrome P450 family protein 0.0019 0.0046 0.0072
Onchocerca volvulus 0.0484 0.6929 1
Plasmodium vivax glutathione reductase, putative 0.0305 0.4282 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0028 0.0179 0.0412
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0046 0.0107
Leishmania major hypothetical protein, conserved 0.0028 0.0179 0.0412
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0046 0.0107
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0028 0.0179 0.0661
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0315 0.0313
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0656 0.1079
Echinococcus multilocularis chromobox protein 1 0.0073 0.0837 0.0835
Trichomonas vaginalis glutamate synthase, putative 0.0028 0.0179 0.0205
Schistosoma mansoni glutamate synthase 0.0028 0.0179 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0189 0.0217
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0028 0.0179 0.0192
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0365 0.0363
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0028 0.0179 0.0205
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0046 0.0107
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0097 0.0095
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0021 0.0076 0.0121
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0064 0.0145
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0028 0.0179 0.0205
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0028 0.0179 0.0205
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.1179 0.1177
Brugia malayi glutamate synthase 0.0028 0.0179 0.0291
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0046 0.0044
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0598 0.8604 1
Entamoeba histolytica hypothetical protein 0.0023 0.0097 0.011
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0021 0.0076 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0837 0.097
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0286 0.0284
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0046 0.0102
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0305 0.4282 0.6146
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0046 0.0107
Mycobacterium ulcerans monoxygenase 0.0028 0.0179 0.0432
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0028 0.0179 0.0417
Plasmodium falciparum thioredoxin reductase 0.0305 0.4282 1
Brugia malayi Cation transporter family protein 0.0021 0.0076 0.0121
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0021 0.0076 0.0121
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0019
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0365 0.0363
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1226 0.2021
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0106 0.1329 0.31
Trypanosoma cruzi trypanothione reductase, putative 0.0106 0.1329 0.31
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0106 0.1329 0.31
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0028 0.0179 0.0176
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.011 0.1385 0.1607
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0076 0.0121
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0046 0.0102
Schistosoma mansoni cytochrome P450 0.0019 0.0046 0.0044
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0028 0.0179 0.0253
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0016 0.0002 0.0005
Schistosoma mansoni sulfide quinone reductase 0.0028 0.0179 0.0176
Echinococcus multilocularis peregrin 0.0032 0.0231 0.0228
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0021 0.0076 0.0121
Schistosoma mansoni nAChR subunit 0.0021 0.0076 0.0074
Brugia malayi chromobox protein homolog 3 0.0041 0.0365 0.0599
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0046 0.0107
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0553 0.1288
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0046 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0046 0.0063
Loa Loa (eye worm) ACC-1 protein 0.0021 0.0076 0.0121
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0046 0.0063
Schistosoma mansoni nAChR subunit 0.0021 0.0076 0.0074
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0028 0.0179 0.0176
Loa Loa (eye worm) inositol-1 0.0037 0.0311 0.051
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0253 0.03
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0028 0.0179 0.0205
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0028 0.0179 0.0291
Onchocerca volvulus 0.0028 0.0179 0.015
Brugia malayi cytochrome P450 0.0019 0.0046 0.0072
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0028 0.0179 0.0253
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0292 0.4082 0.5833
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0315 0.0516
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Mycobacterium tuberculosis Probable oxidoreductase 0.0487 0.6965 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0021 0.0076 0.0121
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0311 0.0359
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0487 0.6965 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0106 0.1329 0.31
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0028 0.0179 0.0412
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0028 0.0179 0.0661
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0207 0.0484
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0014
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0028 0.0179 0.0205
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0106 0.1329 0.31
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0046 0.0063
Giardia lamblia Kinase, PLK 0.0099 0.1226 0.1423
Echinococcus multilocularis microtubule associated protein 2 0.0692 1 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1652 0.2723
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0028 0.0179 0.0176
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0076 0.0074
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0028 0.0179 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0106 0.1329 0.31
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0016 0.0014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0296 0.0294
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0311 0.0359
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.035 0.0404
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.8604 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0365 0.0422
Trichomonas vaginalis apoptosis inducing factor, putative 0.0028 0.0179 0.0205
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0649 0.0647
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0195 0.0193
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0028 0.0179 0.0192
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0028 0.0179 0.0176
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0046 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0106 0.1329 0.31
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0699 0.1628
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0106 0.1329 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.8604 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0487 0.6965 1
Plasmodium falciparum thioredoxin reductase 0.0106 0.1329 0.31
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0028 0.0179 0.0412
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0952 0.1567
Trypanosoma cruzi trypanothione reductase, putative 0.0305 0.4282 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0106 0.1329 0.1905
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0028 0.0179 0.0432
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0046 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1226 0.1423
Echinococcus granulosus glycine receptor subunit beta 0.0021 0.0076 0.0074
Brugia malayi polk-prov protein 0.003 0.0207 0.0339
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0578 0.0951
Toxoplasma gondii thioredoxin reductase 0.0305 0.4282 1
Giardia lamblia PHD finger protein 15 0.0029 0.0195 0.0225
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0411 0.0489
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Schistosoma mansoni nAChR subunit 0.0021 0.0076 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0666 0.0664
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1226 0.1423
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0699 0.0697
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0021 0.0076 0.0074
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0028 0.0179 0.0205
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0837 0.1378
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0195 0.0452
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0491 0.0568
Loa Loa (eye worm) hypothetical protein 0.0038 0.032 0.0525
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.011 0.1385 0.1383
Loa Loa (eye worm) thioredoxin reductase 0.0305 0.4282 0.7066
Echinococcus multilocularis chromatin regulatory protein sir2 0.011 0.1385 0.1383
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0311 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0553 0.0641
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0021 0.0076 0.0121
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1226 0.286
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0043 0.0396 0.065
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0046 0.0063
Loa Loa (eye worm) programmed cell death 8 0.0028 0.0179 0.0291
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0409 0.5815 0.8348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0365 0.0422
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.8604 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0046 0.0063
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0311 0.0309
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0292 0.4082 0.5859
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0028 0.0179 0.0205
Echinococcus granulosus GPCR family 2 0.0017 0.0021 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0046 0.0063
Schistosoma mansoni microtubule-associated protein tau 0.0692 1 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0046 0.0063
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0028 0.0179 0.0253
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0028 0.0179 0.0205
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0578 0.0951
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0021 0.0076 0.0121
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0106 0.1329 0.31
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.035 0.0818
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0028 0.0179 0.0253
Loa Loa (eye worm) hypothetical protein 0.0078 0.0919 0.1514
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0028 0.0179 0.0412
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0028 0.0179 0.0432
Brugia malayi Bromodomain containing protein 0.0038 0.0331 0.0543
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0106 0.1329 0.31
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0256 0.0597
Mycobacterium tuberculosis Probable reductase 0.0409 0.5815 0.8348
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0076 0.0121
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0046 0.0107
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0078 0.0913 0.1504
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.011 0.1385 0.1607
Schistosoma mansoni chromatin regulatory protein sir2 0.011 0.1385 0.1383
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0046 0.0107
Schistosoma mansoni nAChR subunit 0.0021 0.0076 0.0074
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0699 0.0697
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0699 0.1001
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0021 0.0076 0.0121
Plasmodium vivax ferrodoxin reductase, putative 0.0028 0.0179 0.0412
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0028 0.0179 0.0417
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0028 0.0179 0.0205
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Mycobacterium ulcerans dehydrogenase 0.0028 0.0179 0.0432
Echinococcus granulosus chromobox protein 1 0.0073 0.0837 0.0835
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0021 0.0076 0.0074
Schistosoma mansoni nAChR subunit 0.0021 0.0076 0.0074
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0315 0.0313
Giardia lamblia Fructose-bisphosphate aldolase 0.0598 0.8604 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0106 0.1329 0.31
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0097 0.0233
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0106 0.0243
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0046 0.0107
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0028 0.0179 0.0412
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.035 0.0404
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0028 0.0179 0.0417
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.8604 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0919 0.0917
Brugia malayi Cation transporter family protein 0.0021 0.0076 0.0121
Echinococcus multilocularis 0.0019 0.0046 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0076 0.0121
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.035 0.0813
Echinococcus multilocularis dna polymerase kappa 0.004 0.035 0.0348
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0633 0.0631
Schistosoma mansoni hypothetical protein 0.0029 0.0195 0.0193
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0837 0.097
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0046 0.0063
Loa Loa (eye worm) hypothetical protein 0.0055 0.0578 0.0951
Echinococcus multilocularis GPCR, family 2 0.0017 0.0021 0.0019
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0311 0.0309
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0046 0.0102
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0106 0.1329 0.3104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0699 0.1708
Trichomonas vaginalis glutathione reductase, putative 0.0106 0.1329 0.1542
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0028 0.0179 0.0205
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1226 0.286
Giardia lamblia Thioredoxin reductase 0.0028 0.0179 0.0205
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1226 0.1423
Leishmania major DNA polymerase kappa, putative 0.002 0.0064 0.0145
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0409 0.5815 0.8348
Plasmodium falciparum glutathione reductase 0.0106 0.1329 0.31
Onchocerca volvulus Alhambra homolog 0.0029 0.0195 0.0175
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0106 0.1329 0.1327
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0106 0.1329 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.0028 0.0179 0.0432
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0311 0.0721
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.8604 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0028 0.0179 0.0661
Brugia malayi Pre-SET motif family protein 0.0061 0.0666 0.1096
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0097 0.0095
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0888 0.0886
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0106 0.1329 0.31
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0195 0.0452
Schistosoma mansoni hypothetical protein 0.0038 0.032 0.0318
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1226 0.1224
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0028 0.0179 0.0432
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0028 0.0179 0.0412
Brugia malayi MAP kinase sur-1 0.0053 0.0553 0.091
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1226 0.1224
Plasmodium falciparum glutathione reductase 0.0305 0.4282 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0106 0.1329 0.1542
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0097 0.0095
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0046 0.0102
Schistosoma mansoni nAChR subunit 0.0021 0.0076 0.0074
Echinococcus granulosus thioredoxin glutathione reductase 0.0306 0.4297 0.4296
Loa Loa (eye worm) cytochrome P450 0.0019 0.0046 0.0072
Schistosoma mansoni inositol monophosphatase 0.0037 0.0311 0.0309
Schistosoma mansoni hypothetical protein 0.0028 0.0179 0.0176
Onchocerca volvulus Huntingtin homolog 0.0128 0.1652 0.23
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0106 0.1329 0.31
Echinococcus multilocularis nAChR subunit 0.0021 0.0076 0.0074
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0028 0.0179 0.0176
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0028 0.0179 0.0192
Schistosoma mansoni chromobox protein 0.0073 0.0837 0.0835
Schistosoma mansoni kinase 0.005 0.051 0.0508
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0179 0.0412
Schistosoma mansoni nAChR subunit 0.0021 0.0076 0.0074
Trypanosoma brucei protein kinase, putative 0.0053 0.0553 0.1292
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0919 0.0917
Leishmania major cytochrome p450-like protein 0.0019 0.0046 0.0102
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.035 0.0813
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0064 0.0089
Loa Loa (eye worm) hypothetical protein 0.005 0.0504 0.0829
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Echinococcus granulosus glycine receptor subunit beta 0.0021 0.0076 0.0074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0487 0.6965 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0028 0.0179 0.0291
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0076 0.0121
Loa Loa (eye worm) LGC-31 protein 0.0021 0.0076 0.0121
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0016 0.0014
Brugia malayi Heterochromatin protein 1 0.0073 0.0837 0.1378
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0409 0.5815 0.8348
Schistosoma mansoni chromatin regulatory protein sir2 0.011 0.1385 0.1383
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0253 0.0361
Brugia malayi Bromodomain containing protein 0.0032 0.0231 0.0377
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0106 0.1329 0.31
Loa Loa (eye worm) hypothetical protein 0.0032 0.0235 0.0384
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.6059 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.011 0.1385 0.323
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0021 0.0076 0.0121
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0409 0.5815 0.8338
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0699 0.1708
Brugia malayi Cytochrome P450 family protein 0.0019 0.0046 0.0072
Loa Loa (eye worm) transcriptional regulator 0.011 0.1385 0.2283
Trypanosoma cruzi NADH dehydrogenase, putative 0.0028 0.0179 0.0412
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0021 0.0076 0.0074
Schistosoma mansoni disulfide oxidoreductase 0.0028 0.0179 0.0176
Brugia malayi PHD-finger family protein 0.0029 0.0195 0.0319
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0106 0.1329 0.3104
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0028 0.0179 0.0205
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0097 0.0222
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0046 0.0107
Loa Loa (eye worm) hypothetical protein 0.0028 0.0179 0.0291
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0025 0.0038
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0028 0.0179 0.0412
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.8604 1
Leishmania major cytochrome p450-like protein 0.0019 0.0046 0.0102
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0021 0.0076 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0121
Loa Loa (eye worm) hypothetical protein 0.0041 0.0365 0.0599
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.8604 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1226 0.1224
Chlamydia trachomatis thioredoxin reductase 0.0028 0.0179 0.0661
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1226 0.1423
Leishmania major NADH dehydrogenase, putative 0.0028 0.0179 0.0412
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.011 0.1385 0.1607
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0021 0.0019
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0097 0.0222
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0046 0.0107
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0021 0.0076 0.0074
Trypanosoma brucei trypanothione reductase 0.0305 0.4282 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0097 0.0222
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0028 0.0179 0.0253

Activities

Activity type Activity value Assay description Source Reference
(functional) = 92 % T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.)) ChEMBL. 6876085
Curative Index (functional) = 92 % T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.)) ChEMBL. 6876085
Mortality (functional) = 0 Mortality of P388 leukemia in mice at a dose of 200 mg/kg, schedule (q.d.)); 5 mice dead out of 5 treated mice ChEMBL. 6876085
Mortality (functional) = 0 Mortality of P388 leukemia in mice at a dose of 100 mg/kg, schedule (q.d.)); 0 mice dead out of 5 treated mice ChEMBL. 6876085
Mortality (functional) = 0 Mortality of P388 leukemia in mice at a dose of 50 mg/kg, schedule (q.d.)); 0 mice dead out of 5 treated mice ChEMBL. 6876085
Mortality (functional) = 0 Mortality of P388 leukemia in mice at a dose of 25 mg/kg, schedule (q.d.)); 0 mice dead out of 6 treated mice ChEMBL. 6876085
Survival time (functional) = 0 day Survival time(T/C) of mice against P388 leukemia at a dose of 100 mg/kg, schedule (q.d.); 11.0 treated by 11.4 control ChEMBL. 6876085
Survival time (functional) = 0 day Survival time(T/C) of mice against P388 leukemia at a dose of 50 mg/kg, schedule (q.d.); 10.5 treated by 11.4 control ChEMBL. 6876085
Survival time (functional) = 0 day Survival time(T/C) of mice against P388 leukemia at a dose of 25 mg/kg, schedule (q.d.); 10.9 treated by 11.8 control ChEMBL. 6876085
T/C (functional) Toxic 0 % T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.). ChEMBL. 6876085
T/C (functional) = 92 % T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.)) ChEMBL. 6876085
T/C (functional) = 92 % T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.)) ChEMBL. 6876085
T/C (functional) = 96 % T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.)) ChEMBL. 6876085
T/C (functional) = 96 % T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.)) ChEMBL. 6876085
Weight change difference (functional) = -4.3 g Weight change in mice against P388 leukemia ChEMBL. 6876085
Weight change difference (functional) = -4.3 g Weight change in mice against P388 leukemia ChEMBL. 6876085
Weight change difference (functional) = -3.2 g Weight change in mice against P388 leukemia ChEMBL. 6876085
Weight change difference (functional) = -3.2 g Weight change in mice against P388 leukemia ChEMBL. 6876085
Weight change difference (functional) = -1.6 g Weight change in mice against P388 leukemia ChEMBL. 6876085
Weight change difference (functional) = -1.6 g Weight change in mice against P388 leukemia ChEMBL. 6876085

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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