TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 651.482 | Formula: C31H30Cl2F2N2O7
H donors: 1 H acceptors: 3 LogP: 5.98 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: [O-][n+]1cc(Cl)c(c(c1)Cl)C[C@@H](c1ccc(c(c1)OCC1CC1)OC(F)F)OC(=O)c1ccc(c(c1)OCC1CC1)NC(=O)C
InChi: 1S/C31H30Cl2F2N2O7/c1-17(38)36-25-8-6-21(11-28(25)41-15-18-2-3-18)30(39)43-27(12-22-23(32)13-37(40)14-24(22)33)20-7-9-26(44-31(34)35)29(10-20)42-16-19-4-5-19/h6-11,13-14,18-19,27,31H,2-5,12,15-16H2,1H3,(H,36,38)/t27-/m0/s1
InChiKey: XQQZUVVOBMJVNU-MHZLTWQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0031	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0146	0.0138
Onchocerca volvulus		0.0073	0.0083	0.2998
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0043	0.0033	0.0033
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0056	0.0055	0.0053
Loa Loa (eye worm)	indoleamine 2,3-dioxygenase	0.0474	0.0743	0.0735
Echinococcus granulosus	cpg binding protein	0.0026	0.0005	0.0005
Echinococcus granulosus	tar DNA binding protein	0.0049	0.0043	0.0043
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0048	0.0041	0.0039
Schistosoma mansoni	cpg binding protein	0.0026	0.0005	0.0003
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.2725	0.445	0.4446
Trichomonas vaginalis	set domain proteins, putative	0.0188	0.0272	0.0618
Trichomonas vaginalis	CMGC family protein kinase	0.2311	0.3768	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0151	0.0212	0.0212
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.2311	0.3768	0.3763
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0025	0.0017
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.2725	0.445	0.4449
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.2311	0.3768	0.3767
Schistosoma mansoni	hypothetical protein	0.0474	0.0743	0.0741
Echinococcus granulosus	carbonic anhydrase	0.2725	0.445	0.445
Brugia malayi	hypothetical protein	0.0359	0.0553	0.0551
Brugia malayi	thymidylate synthase	0.0101	0.0128	0.0126
Schistosoma mansoni	sex comb on midleg homolog	0.0038	0.0025	0.0023
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0042	0.0032	0.003
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0032	0.0024
Echinococcus granulosus	carbonic anhydrase	0.2725	0.445	0.445
Brugia malayi	mbt repeat family protein	0.0038	0.0025	0.0022
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0037	0.0023	0.002
Schistosoma mansoni	hypothetical protein	0.0229	0.034	0.0338
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.0124	0.0122
Echinococcus multilocularis	carbonic anhydrase	0.2725	0.445	0.4449
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0043	0.0033	0.0031
Schistosoma mansoni	integrin beta subunit	0.0122	0.0163	0.0161
Schistosoma mansoni	bromodomain containing protein	0.01	0.0128	0.0126
Echinococcus multilocularis	cpg binding protein	0.0026	0.0005	0.0003
Trichomonas vaginalis	CMGC family protein kinase	0.2311	0.3768	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0045	0.0037	0.0035
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0056	0.0055	0.0053
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0038	0.0025	0.0022
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0045	0.0037	0.0035
Echinococcus multilocularis	tar DNA binding protein	0.0049	0.0043	0.0041
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0027	0.0007	0.0005
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0151	0.0212	0.0209
Schistosoma mansoni	cpg binding protein	0.0026	0.0005	0.0003
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0101	0.0128	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0027	0.0007	0.0005
Echinococcus multilocularis	integrin beta 2	0.0153	0.0215	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0014	0.0006
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.2311	0.3768	0.3767
Onchocerca volvulus		0.0188	0.0272	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0038	0.0025	0.0834
Brugia malayi	indoleamine 2,3-dioxygenase	0.0474	0.0743	0.0741
Schistosoma mansoni	carbonic anhydrase-related	0.2725	0.445	0.4449
Loa Loa (eye worm)	hypothetical protein	0.0359	0.0553	0.0545
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.2311	0.3768	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0145	0.0137
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0101	0.0128	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0075	0.0066
Loa Loa (eye worm)	hypothetical protein	0.006	0.0061	0.0053
Loa Loa (eye worm)	MBCTL1	0.0043	0.0033	0.0025
Loa Loa (eye worm)	hypothetical protein	0.2725	0.445	0.4446
Brugia malayi	hypothetical protein	0.0031	0.0014	0.0012
Echinococcus granulosus	mitogen activated protein kinase	0.2311	0.3768	0.3768
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0043	0.0033	0.0031
Giardia lamblia	Kinase, CMGC MAPK	0.2311	0.3768	1
Schistosoma mansoni	hypothetical protein	0.2725	0.445	0.4449
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.2725	0.445	0.4449
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0056	0.0055	0.0047
Schistosoma mansoni	hypothetical protein	0.0474	0.0743	0.0741
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0165	0.0234	0.0226
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0056	0.0055	0.0053
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0056	0.0055	0.0055
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.2725	0.445	0.4449
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0045	0.0037	0.0078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.0212	0.021
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.0212	0.021
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0027	0.0007	0.0007
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0045	0.0037	0.0037
Echinococcus granulosus	carbonic anhydrase	0.2725	0.445	0.445
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0033	0.0025
Brugia malayi	latrophilin 2 splice variant baaae	0.0029	0.001	0.0008
Echinococcus granulosus	mitogen activated protein kinase 3	0.2311	0.3768	0.3768
Echinococcus multilocularis	thymidylate synthase	0.0101	0.0128	0.0126
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0049	0.0043	0.0035
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0051	0.0046	0.0044
Echinococcus multilocularis	carbonic anhydrase	0.2725	0.445	0.4449
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0112	0.0146	0.0324
Schistosoma mansoni	hypothetical protein	0.0032	0.0016	0.0014
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.0124	0.0116
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0151	0.0212	0.0209
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0146	0.0144
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0051	0.0046	0.0044
Echinococcus granulosus	survival motor neuron protein 1	0.0359	0.0553	0.0553
Echinococcus granulosus	SAM and MBT domain containing protein	0.0038	0.0025	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0049	0.0043	0.0041
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0151	0.0212	0.0212
Brugia malayi	Bromodomain containing protein	0.0119	0.0158	0.0156
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0043	0.0033	0.0031
Brugia malayi	Bromodomain containing protein	0.006	0.0061	0.0059
Schistosoma mansoni	tar DNA-binding protein	0.0049	0.0043	0.0041
Echinococcus granulosus	polycomb protein SCMH1	0.0038	0.0025	0.0025
Plasmodium falciparum	carbonic anhydrase	0.2725	0.445	1
Echinococcus multilocularis	polycomb protein SCMH1	0.0038	0.0025	0.0022
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0101	0.0128	1
Echinococcus granulosus	dnaJ subfamily B	0.0305	0.0465	0.0465
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.2725	0.445	0.4449
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0045	0.0037	0.0035
Echinococcus multilocularis	mitogen activated protein kinase	0.2311	0.3768	0.3767
Brugia malayi	RNA recognition motif domain containing protein	0.0049	0.0043	0.0041
Schistosoma mansoni	carbonic anhydrase	0.2725	0.445	0.4449
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0046	0.0038
Echinococcus granulosus	integrin beta 2	0.0153	0.0215	0.0215
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0101	0.0128	0.0126
Echinococcus multilocularis	survival motor neuron protein 1	0.0359	0.0553	0.0551
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0043	0.0033	0.0031
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.2311	0.3768	0.3767
Schistosoma mansoni	zinc finger protein	0.0032	0.0015	0.0013
Schistosoma mansoni	sex comb on midleg homolog	0.0038	0.0025	0.0023
Echinococcus multilocularis	carbonic anhydrase	0.2725	0.445	0.4449
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0095	0.0118	0.0118
Echinococcus multilocularis	zinc finger protein	0.0032	0.0015	0.0013
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0146	0.0146
Echinococcus granulosus	thymidylate synthase	0.0101	0.0128	0.0128
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0095	0.0118	0.0116
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.0124	0.0122
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0068	0.006
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0046	0.0039	0.0037
Echinococcus granulosus	histone lysine methyltransferase setb	0.0051	0.0046	0.0046
Trypanosoma brucei	protein kinase, putative	0.2311	0.3768	0.3767
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0149	0.0207	0.0207
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.2311	0.3768	0.8467
Loa Loa (eye worm)	hypothetical protein	0.2725	0.445	0.4446
Toxoplasma gondii	hypothetical protein	0.2725	0.445	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2311	0.3768	0.3767
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0042	0.0032	0.003
Schistosoma mansoni	aldehyde dehydrogenase	0.0045	0.0037	0.0035
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0073	0.0083	0.0081
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0056	0.0055	0.0053
Echinococcus granulosus	indoleamine 23 dioxygenase 2	0.0474	0.0743	0.0743
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0037	0.0023	0.0021
Echinococcus multilocularis	geminin	0.0144	0.02	0.0198
Brugia malayi	TAR-binding protein	0.0049	0.0043	0.0041
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0112	0.0146	0.0144
Trichomonas vaginalis	CMGC family protein kinase	0.2311	0.3768	1
Schistosoma mansoni	tar DNA-binding protein	0.0049	0.0043	0.0041
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0056	0.0055	0.0055
Echinococcus multilocularis	transcription factor Dp 1	0.0033	0.0016	0.0014
Brugia malayi	mbt repeat family protein	0.0038	0.0025	0.0022
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0038	0.0025	0.0023
Brugia malayi	hypothetical protein	0.0048	0.0041	0.0039
Loa Loa (eye worm)	mbt repeat family protein	0.0038	0.0025	0.0017
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0027	0.0007	0.0004
Onchocerca volvulus		0.0038	0.0025	0.0834
Schistosoma mansoni	hypothetical protein	0.0144	0.02	0.0198
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0016	0.0008
Mycobacterium ulcerans	thymidylate synthase	0.0101	0.0128	1
Schistosoma mansoni	serine/threonine protein kinase	0.2311	0.3768	0.3767
Loa Loa (eye worm)	hypothetical protein	0.2725	0.445	0.4446
Toxoplasma gondii	aldehyde dehydrogenase	0.0045	0.0037	0.0078
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.2725	0.445	0.4449
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.0212	0.021
Echinococcus multilocularis	indoleamine 2,3 dioxygenase 2	0.0474	0.0743	0.0741
Schistosoma mansoni	tar DNA-binding protein	0.0049	0.0043	0.0041
Echinococcus granulosus	fetal alzheimer antigen falz	0.0037	0.0023	0.0023
Schistosoma mansoni	tar DNA-binding protein	0.0049	0.0043	0.0041
Echinococcus granulosus	transcription factor Dp 1	0.0033	0.0016	0.0016
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0056	0.0055	0.0053
Brugia malayi	MAP kinase sur-1	0.2311	0.3768	0.3767
Onchocerca volvulus		0.0101	0.0128	0.4678
Loa Loa (eye worm)	thymidylate synthase	0.0101	0.0128	0.012
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0056	0.0055	0.0053
Loa Loa (eye worm)	integrin beta-2	0.0207	0.0303	0.0295
Loa Loa (eye worm)	RNA binding protein	0.0049	0.0043	0.0035
Brugia malayi	Integrin beta pat-3 precursor	0.0207	0.0303	0.0301
Brugia malayi	PHD-finger family protein	0.004	0.0029	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0029	0.001	0.0002
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0101	0.0128	0.0126
Brugia malayi	RNA binding protein	0.0049	0.0043	0.0041
Schistosoma mansoni	carbonic anhydrase-related	0.2725	0.445	0.4449
Loa Loa (eye worm)	TAR-binding protein	0.0049	0.0043	0.0035
Echinococcus multilocularis	mitogen activated protein kinase 3	0.2311	0.3768	0.3767
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0101	0.0128	0.0283
Schistosoma mansoni	hypothetical protein	0.0144	0.02	0.0198
Brugia malayi	Kelch motif family protein	0.0031	0.0014	0.0012
Schistosoma mansoni	hypothetical protein	0.0029	0.001	0.0008
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0151	0.0212	0.0209
Schistosoma mansoni	carbonic anhydrase-related	0.2725	0.445	0.4449
Echinococcus granulosus	geminin	0.0144	0.02	0.02
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0101	0.0128	0.0126
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0073	0.0083	0.0081
Schistosoma mansoni	hypothetical protein	0.0305	0.0465	0.0463
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0056	0.0055	0.0053
Brugia malayi	Pre-SET motif family protein	0.0165	0.0234	0.0232
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0056	0.0055	0.5
Echinococcus multilocularis	dnaJ subfamily B	0.0305	0.0465	0.0462
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0146	0.0144
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0101	0.0128	0.0126
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0149	0.0207	0.0205
Mycobacterium tuberculosis	Hypothetical protein	0.0048	0.0041	0.0473
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0056	0.0055	0.0053
Echinococcus granulosus	zinc finger protein	0.0032	0.0015	0.0015
Schistosoma mansoni	survival motor neuron protein	0.0073	0.0083	0.0081
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2311	0.3768	0.3767
Trichomonas vaginalis	CMGC family protein kinase	0.2311	0.3768	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0042	0.0032	0.0024
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0151	0.0212	0.0204
Echinococcus granulosus	histone acetyltransferase MYST2	0.0043	0.0033	0.0033
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.2311	0.3768	0.3767
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0051	0.0046	0.0044

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.21 nM	Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA	ChEMBL.	24400806
IC50 (binding)	= 0.24 nM	Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay	ChEMBL.	24400806

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3113960

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1831829