Detailed information for compound 1019646

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.211 | Formula: C17H14Cl2N2O3
  • H donors: 4 H acceptors: 3 LogP: 2.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(c1ccc(c(c1)Cl)NC(=O)c1cc2c([nH]1)ccc(c2)Cl)O
  • InChi: 1S/C17H14Cl2N2O3/c18-11-2-4-13-10(5-11)7-15(20-13)17(24)21-14-3-1-9(6-12(14)19)16(23)8-22/h1-7,16,20,22-23H,8H2,(H,21,24)
  • InChiKey: BUIYKRGIULRPHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphorylase, glycogen, liver Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum Glycogen phosphorylase, brain form, putative Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Chlamydia trachomatis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Giardia lamblia Glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium hominis glycogen phosphorylase 1 Get druggable targets OG5_126999 All targets in OG5_126999
Loa Loa (eye worm) glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium parvum glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus Glycosyl transferase family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis Glycosyl transferase, family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Neospora caninum hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Onchocerca volvulus Glycogen phosphorylase homolog Get druggable targets OG5_126999 All targets in OG5_126999
Brugia malayi carbohydrate phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0031 0.0054 0.0325
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0191 0.0452 0.2723
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0392 0.5678
Echinococcus granulosus neuropeptide s receptor 0.0463 0.1128 0.4503
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0038 0.2806
Echinococcus granulosus endothelin converting enzyme 1 0.0519 0.1267 0.506
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0414 0.6002
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.0153
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0099 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0066
Giardia lamblia Tyrosyl-tRNA synthetase 0.002 0.0026 0.0377
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0056 0.0116 0.1467
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.033 0.033
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0145 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.069 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0392 0.5678
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 0.0429
Echinococcus multilocularis inhibitor of apoptosis protein 0.0055 0.0112 0.0674
Echinococcus multilocularis musashi 0.0026 0.0042 0.0252
Schistosoma mansoni hypothetical protein 0.0099 0.0222 0.1339
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0074 0.1065
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0072 0.525
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0052
Onchocerca volvulus 0.0056 0.0116 0.1467
Onchocerca volvulus 0.0056 0.0116 0.1467
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0008 0.0031
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0137 0.0827
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0392 0.4948
Loa Loa (eye worm) calpain family protein 1 0.0056 0.0114 0.0114
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0004 0.0064
Loa Loa (eye worm) glycogen phosphorylase 0.013 0.0301 0.0301
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0066 0.0955
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0 0.0002
Loa Loa (eye worm) calpain 5 0.0015 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0099 0.0222 0.1339
Schistosoma mansoni dishevelled 0.001 0 0.0002
Schistosoma mansoni cpg binding protein 0.003 0.005 0.0304
Loa Loa (eye worm) hypothetical protein 0.0119 0.0273 0.0273
Schistosoma mansoni cpg binding protein 0.0028 0.0046 0.028
Echinococcus granulosus tyrosyl tRNA synthetase 0.0036 0.0065 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0392 0.5678
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Schistosoma mansoni hypothetical protein 0.0676 0.1659 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0023 0.0069
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.1071
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0074 0.0929
Echinococcus granulosus calpain 5 0.0021 0.0028 0.0112
Plasmodium falciparum tyrosine--tRNA ligase 0.002 0.0026 0.322
Mycobacterium ulcerans hypothetical protein 0.0023 0.0034 0.0153
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0004 0.0027
Trichomonas vaginalis methionyl-tRNA synthetase, putative 0.0016 0.0015 0.0213
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0519 0.1267 1
Schistosoma mansoni chromobox protein 0.007 0.015 0.0904
Leishmania major hypothetical protein 0.0016 0.0015 0.1071
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0011 0.0011
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0225 0.0536 0.323
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.061 0.8836
Trichomonas vaginalis chromobox protein, putative 0.007 0.015 0.2174
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.0064
Plasmodium vivax tyrosine--tRNA ligase, putative 0.002 0.0026 0.3245
Trypanosoma cruzi tyrosyl or methionyl-tRNA synthetase, putative 0.0016 0.0015 0.1071
Echinococcus multilocularis calpain A 0.0058 0.0121 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 0.0429
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0016 0.0015 0.0015
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0028 0.2049
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0121 0.0726
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0137 0.0137
Brugia malayi hypothetical protein 0.0016 0.0016 0.0016
Onchocerca volvulus 0.0028 0.0046 0.0586
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0338
Schistosoma mansoni hypothetical protein 0.0676 0.1659 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0081 0.1173
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0027 0.1933
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0004 0.0553
Echinococcus granulosus geminin 0.0676 0.1659 0.6624
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0206 0.124
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0 0.0002
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0027 0.1933
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0119 0.0273 0.0273
Brugia malayi intermediate filament protein 0.0026 0.0042 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.2467
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.061 0.8836
Echinococcus multilocularis dna polymerase kappa 0.002 0.0027 0.016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0019 0.0036
Leishmania major DNA polymerase eta, putative 0.002 0.0027 0.1933
Loa Loa (eye worm) peptidase family M13 containing protein 0.042 0.1021 0.1021
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0056 0.0116 0.0464
Loa Loa (eye worm) hypothetical protein 0.0426 0.1038 0.1038
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0004 0.0064
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.1128 0.6798
Brugia malayi beta-lactamase family protein 0.0036 0.0066 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0289 0.0289
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0198 0.047 0.047
Echinococcus granulosus Glycosyl transferase family 35 0.013 0.0301 0.12
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0019
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.061 0.061
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.2467
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0028 0.2049
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0004 0.0018
Schistosoma mansoni hypothetical protein 0.0031 0.0054 0.0325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Schistosoma mansoni DNA polymerase eta 0.002 0.0027 0.016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0038
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0004 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0034
Toxoplasma gondii peptidase family M13 protein 0.0519 0.1267 1
Trypanosoma brucei kinesin, putative 0.0015 0.0012 0.0905
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0088 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0015 0.0213
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0028 0.2049
Toxoplasma gondii tRNA binding domain-containing protein 0.0016 0.0015 0.0116
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0137 0.1937
Onchocerca volvulus 0.001 0 0.0003
Echinococcus granulosus chromobox protein 2 0.0011 0.0004 0.0018
Giardia lamblia Methionyl-tRNA synthetase 0.0016 0.0015 0.0213
Mycobacterium leprae Probable lipase LipE 0.0036 0.0066 0.026
Echinococcus granulosus regulator of G protein signaling 7 0.001 0 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0066 0.4803
Loa Loa (eye worm) hypothetical protein 0.0426 0.1038 0.1038
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0191 0.0452 0.2723
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0004 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.1699
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.069 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0064
Loa Loa (eye worm) hypothetical protein 0.0426 0.1038 0.1038
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0066 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0088 0.0531
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0061 0.0127 0.0127
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0028 0.2049
Loa Loa (eye worm) acetyltransferase 0.0142 0.033 0.033
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0027 0.0094
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0027 0.1933
Echinococcus multilocularis chromobox protein 1 0.007 0.015 0.0904
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0004 0.0553
Loa Loa (eye worm) calpain family protein 1 0.0041 0.0078 0.0078
Onchocerca volvulus 0.0055 0.0112 0.1413
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0296
Schistosoma mansoni intermediate filament proteins 0.0026 0.0042 0.0252
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.1699
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Schistosoma mansoni neprilysin-2 (M13 family) 0.0191 0.0452 0.2723
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0004 0.0027
Echinococcus granulosus Solute carrier family 22 5 0.1016 0.2505 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0034 0.0153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.069 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0066 0.0409
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0066 0.0409
Trypanosoma brucei tyrosyl-tRNA synthetase, putative 0.0016 0.0015 0.1071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0054 0.0325
Trypanosoma brucei unspecified product 0.002 0.0027 0.1933
Echinococcus multilocularis endothelin converting enzyme 1 0.0519 0.1267 0.764
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0072 0.525
Entamoeba histolytica glycogenphosphorylase, putative 0.0056 0.0116 0.1632
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.008 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0034 0.0153
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0027 0.0094
Trypanosoma brucei tyrosyl/methionyl-tRNA synthetase, putative 0.0016 0.0015 0.1071
Toxoplasma gondii tRNA synthetases class I family protein 0.002 0.0026 0.0205
Loa Loa (eye worm) hypothetical protein 0.0519 0.1267 0.1267
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.069 1
Onchocerca volvulus 0.0036 0.0066 0.0832
Echinococcus granulosus glycogen phosphorylase 0.013 0.0301 0.12
Loa Loa (eye worm) hypothetical protein 0.0519 0.1267 0.1267
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.282
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0066 0.4803
Echinococcus granulosus lamin dm0 0.0026 0.0042 0.0167
Loa Loa (eye worm) beta-lactamase 0.0036 0.0066 0.0066
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.0025 0.0038 0.2806
Schistosoma mansoni hypothetical protein 0.0099 0.0222 0.1339
Giardia lamblia Glycogen phosphorylase 0.013 0.0301 0.4356
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0008 0.0051
Schistosoma mansoni hypothetical protein 0.0052 0.0105 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0064
Brugia malayi beta-lactamase 0.0036 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0016 0.0015 0.015
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.008 0.116
Echinococcus granulosus aminoacyl tRNA synthase complex interacting 0.0016 0.0015 0.0059
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Leishmania major tyrosyl or methionyl-tRNA synthetase-like protein 0.0016 0.0015 0.1071
Brugia malayi CHD4 protein 0.0013 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0789
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0015 0.0213
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0038 0.2806
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.2467
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0028 0.2049
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0066 0.0066
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0028 0.2049
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0028 0.2049
Echinococcus granulosus Chromobox protein 3 0.0011 0.0004 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0296
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.008 0.0632
Schistosoma mansoni dishevelled 0.001 0 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0296
Echinococcus multilocularis lamin dm0 0.0026 0.0042 0.0252
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0008 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.069 1
Loa Loa (eye worm) hypothetical protein 0.042 0.1021 0.1021
Giardia lamblia DINP protein human, muc B family 0.002 0.0027 0.0384
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0325 0.2475
Brugia malayi MH2 domain containing protein 0.0126 0.0289 0.0289
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0325 0.2358
Schistosoma mansoni neprilysin 0.0099 0.0222 0.1339
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0004 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0004 0.0016
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0028 0.0169
Loa Loa (eye worm) hypothetical protein 0.0225 0.0536 0.0536
Echinococcus granulosus regulator of G protein signaling 7 0.001 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0028 0.2049
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0034 0.0153
Echinococcus multilocularis Chromo domain 0.0011 0.0004 0.0027
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0008 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.069 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0034 0.0153
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0114 0.0689
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0027 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0414 0.6002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.4026 1 1
Plasmodium vivax calpain, putative 0.0021 0.0028 0.3511
Echinococcus multilocularis cpg binding protein 0.003 0.005 0.0304
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0028 0.2049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0074
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0028 0.2049
Trichomonas vaginalis chromobox protein, putative 0.007 0.015 0.2174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0296
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.1128 0.6798
Loa Loa (eye worm) helicase 0.0011 0.0004 0.0004
Brugia malayi beta-lactamase family protein 0.0036 0.0066 0.0066
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0289 0.0289
Mycobacterium tuberculosis Conserved protein 0.0036 0.0066 0.0409
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0055 0.0112 0.0112
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0019 0.0158
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0069 0.0277
Mycobacterium ulcerans lipase LipD 0.0036 0.0066 0.0409
Brugia malayi SET domain containing protein 0.0012 0.0006 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.008 0.116
Loa Loa (eye worm) zinc metallopeptidase 4 0.0092 0.0206 0.0206
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0027 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0015 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0653
Schistosoma mansoni z-protein (S1r protein) 0.001 0 0.0002
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.0426 0.1038 0.1038
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0011 0.0011
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0066 0.0409
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0081 0.1022
Mycobacterium ulcerans zinc metalloprotease 0.0519 0.1267 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.0116 0.1632
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0016 0.0015 0.015
Schistosoma mansoni peptidylglycine monooxygenase 0.0119 0.0273 0.1647
Toxoplasma gondii exonuclease III APE 0.0019 0.0023 0.0184
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0034 0.0153
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0066 0.0066
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0121 0.0726
Echinococcus multilocularis tyrosyl tRNA synthetase 0.0036 0.0065 0.039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0088 0.0088
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0225 0.0536 0.0536
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0054 0.0216
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0137 0.0548
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0191 0.0452 0.2723
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.069 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0118 0.0932
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0392 0.5678
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0519 0.1267 0.1267
Loa Loa (eye worm) hypothetical protein 0.0519 0.1267 0.1267
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.033 0.1989
Echinococcus multilocularis glycogen phosphorylase 0.013 0.0301 0.1812
Entamoeba histolytica tyrosyl-tRNA synthetase, putative 0.002 0.0026 0.0314
Schistosoma mansoni lamin 0.0026 0.0042 0.0252
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0206 0.124
Trypanosoma brucei antigen, putative 0.0021 0.0028 0.2049
Echinococcus granulosus glycogen phosphorylase 0.013 0.0301 0.12
Brugia malayi POT family protein 0.0336 0.0813 0.0813
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0019 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0066 0.0397
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.0116 0.1632
Loa Loa (eye worm) hypothetical protein 0.0328 0.0792 0.0792
Onchocerca volvulus 0.0035 0.0062 0.0784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0088 0.0352
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0071 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0064
Schistosoma mansoni hypothetical protein 0.0099 0.0222 0.1339
Loa Loa (eye worm) hypothetical protein 0.0041 0.0078 0.0078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0223 0.0223
Loa Loa (eye worm) POT family protein 0.0336 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Schistosoma mansoni glycogen phosphorylase 0.013 0.0301 0.1812
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.042 0.1021 0.1021
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.061 0.061
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0099 0.0222 0.1339
Echinococcus multilocularis calpain 0.0021 0.0028 0.0169
Schistosoma mansoni tyrosyl-tRNA synthetase 0.0036 0.0065 0.039
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0392 0.5678
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.069 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0066 0.4803
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0071 0.1035
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0062
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0023 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0392 0.5678
Echinococcus multilocularis GPCR, family 2 0.0031 0.0054 0.0325
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0028 0.0169
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0028 0.2049
Onchocerca volvulus 0.0031 0.0052 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0034 0.0153
Brugia malayi methionyl-tRNA synthetase 0.0016 0.0015 0.0015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.1699
Echinococcus multilocularis hypothetical protein 0.0021 0.0028 0.0169
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0038 0.0304
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.002 0.0026 0.0377
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0066 0.0397
Trypanosoma brucei tyrosyl-tRNA synthetase, putative 0.002 0.0026 0.1894
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0064
Brugia malayi calpain family protein 1 0.0056 0.0114 0.0114
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0027 0.016
Echinococcus multilocularis lamin 0.0026 0.0042 0.0252
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0055 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0066
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0125 0.0756
Echinococcus granulosus dna polymerase eta 0.002 0.0027 0.0106
Echinococcus multilocularis dna polymerase eta 0.002 0.0027 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0066 0.0955
Schistosoma mansoni hypothetical protein 0.0099 0.0222 0.1339
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0066 0.0397
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0028 0.2049
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0056 0.0116 0.0811
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0038 0.2806
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0006 0.0036
Onchocerca volvulus 0.0011 0.0004 0.0056
Onchocerca volvulus 0.0026 0.0042 0.0528
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Echinococcus granulosus inhibitor of apoptosis protein 0.0055 0.0112 0.0447
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0121 0.0726
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0059 0.0122 0.0122
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0023 1
Loa Loa (eye worm) hypothetical protein 0.042 0.1021 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0064
Schistosoma mansoni hypothetical protein 0.0031 0.0054 0.0325
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0066 0.0263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0088 0.0531
Leishmania major tyrosyl-tRNA synthetase, putative 0.002 0.0026 0.1894
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0042 0.0042
Brugia malayi carbohydrate phosphorylase 0.013 0.0301 0.0301
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0027 0.0384
Echinococcus granulosus segment polarity protein dishevelled 0.001 0 0.0001
Schistosoma mansoni dep domain containing protein 0.001 0 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0034
Echinococcus granulosus calpain A 0.0021 0.0028 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0653
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0028 0.2049
Toxoplasma gondii hypothetical protein 0.001 0 0.0002
Schistosoma mansoni calpain (C02 family) 0.0021 0.0028 0.0169
Loa Loa (eye worm) hypothetical protein 0.0426 0.1038 0.1038
Trypanosoma brucei unspecified product 0.0014 0.0011 0.0789
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0137 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0066 0.0955
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0121 0.0481
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0004 0.0064
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0004 0.0027
Echinococcus granulosus intermediate filament protein 0.0026 0.0042 0.0167
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0027 0.1933
Schistosoma mansoni hypothetical protein 0.0099 0.0222 0.1339
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0027
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.0301 0.432
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0055 0.0112 0.0674
Plasmodium vivax methionine-tRNA ligase, putative 0.0016 0.0015 0.1836
Echinococcus granulosus dna polymerase kappa 0.002 0.0027 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.0153
Echinococcus multilocularis calpain family protein 1, d 0.0041 0.0078 0.0469
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0054 0.0216
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0028 0.0169
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Brugia malayi Peptidase family M13 containing protein 0.0519 0.1267 0.1267
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0004 0.0004
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0036 0.0219
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0041
Schistosoma mansoni endothelin-converting enzyme-related 0.0092 0.0206 0.124
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0027 0.1933
Trypanosoma cruzi kinesin, putative 0.0015 0.0012 0.0905
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0028 0.2049
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0137 0.0827
Leishmania major hypothetical protein, conserved 0.0036 0.0066 0.4803
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Onchocerca volvulus 0.0012 0.0006 0.0075
Echinococcus granulosus chromobox protein 1 0.007 0.015 0.0599
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0088 0.0531
Onchocerca volvulus Glycogen phosphorylase homolog 0.013 0.0301 0.3797
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0088 0.0531
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0004 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0015 0.0213
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0004 0.0027
Onchocerca volvulus 0.0011 0.0004 0.0056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0509 0.1244 0.7498
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0066 0.0409
Brugia malayi hypothetical protein 0.0011 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0789
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0054 0.0054
Onchocerca volvulus 0.0328 0.0792 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0038 0.5089
Echinococcus granulosus cpg binding protein 0.003 0.005 0.0201
Loa Loa (eye worm) calpain 0.0021 0.0028 0.0028
Mycobacterium ulcerans hypothetical protein 0.0036 0.0066 0.0409
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0038 0.4809
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0137 0.0137
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0056 0.0116 0.0811
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0019 0.2208
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0137 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0066 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0392 0.5678
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0027 0.1933
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0004 0.0064
Echinococcus multilocularis chromobox protein 1 0.007 0.015 0.0904
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0027 0.0094
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0225 0.0536 0.323
Loa Loa (eye worm) hypothetical protein 0.0426 0.1038 0.1038
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0066 0.0955
Mycobacterium tuberculosis Conserved protein 0.0036 0.0066 0.0409
Echinococcus multilocularis calpain 5 0.0021 0.0028 0.0169
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0027 0.1933
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.061 0.8836
Onchocerca volvulus 0.0036 0.0066 0.0832
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0137 1
Brugia malayi Heterochromatin protein 1 0.007 0.015 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0027 0.0322
Schistosoma mansoni cpg binding protein 0.003 0.005 0.0304
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.069 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0027 0.1933
Loa Loa (eye worm) hypothetical protein 0.0068 0.0145 0.0145
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.0064
Mycobacterium tuberculosis Conserved protein 0.0036 0.0066 0.0409
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0 0.0002
Mycobacterium ulcerans beta-lactamase 0.0036 0.0066 0.0409
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.008 0.032
Brugia malayi N-terminal motif family protein 0.0198 0.047 0.047
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.0153
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0055 0.0112 0.0447
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0055 0.0112 0.0674
Echinococcus granulosus Chromo domain 0.0011 0.0004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0019
Onchocerca volvulus 0.0036 0.0066 0.0832
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0191 0.0452 0.2723
Entamoeba histolytica calpain large subunit domain III containing protein 0.0015 0.0012 0.0117
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0027
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0004 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0066 0.0955
Loa Loa (eye worm) hypothetical protein 0.0056 0.0114 0.0114
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0042 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0171
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0036 0.0219
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0519 0.1267 0.764
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0027 0.0094
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0013 0.0188
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.032 0.1278
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0789
Brugia malayi chromobox protein homolog 3 0.0039 0.0074 0.0074
Echinococcus granulosus chromobox protein 1 0.007 0.015 0.0599
Schistosoma mansoni chromobox protein 0.0011 0.0004 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.002 0.0296
Echinococcus granulosus GPCR family 2 0.0031 0.0054 0.0216
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.0301 0.432
Brugia malayi Protein cec-1. 0.0011 0.0004 0.0004
Schistosoma mansoni dopamine-beta-monooxygenase 0.0119 0.0273 0.1647
Schistosoma mansoni inhibitor of apoptosis protein 0.0055 0.0112 0.0674
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.061 0.8836
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.061 0.8836
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0034
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0551 0.4278
Echinococcus granulosus calpain A 0.0058 0.0121 0.0481
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0206 0.124
Echinococcus multilocularis aminoacyl tRNA synthase complex interacting 0.0016 0.0015 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Brugia malayi CXXC zinc finger family protein 0.0028 0.0046 0.0046
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0034 0.0429
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.008 0.0632
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0325 0.2475
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0028 0.2049
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0004 0.0553
Entamoeba histolytica protein kinase, putative 0.0015 0.0012 0.0117
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.0301 0.4356
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0027 0.1933
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0008 0.0051
Trypanosoma brucei unspecified product 0.0014 0.0011 0.0789
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0023 0.0275
Toxoplasma gondii methionyl-tRNA synthetase 0.0016 0.0015 0.0116
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0093
Loa Loa (eye worm) hypothetical protein 0.042 0.1021 0.1021
Echinococcus multilocularis geminin 0.0676 0.1659 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0092 0.0092
Toxoplasma gondii ABC1 family protein 0.0036 0.0066 0.052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.061 0.8836
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.069 1
Loa Loa (eye worm) peptidase family M13 containing protein 0.042 0.1021 0.1021
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0066 0.026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0066 0.0409
Schistosoma mansoni hypothetical protein 0.0031 0.0054 0.0325
Leishmania major hypothetical protein, conserved 0.0039 0.0072 0.525
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0225 0.0536 0.2139
Leishmania major DNA polymerase kappa, putative 0.002 0.0027 0.1933
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0042
Mycobacterium leprae probable zinc metalloprotease 0.0519 0.1267 1
Schistosoma mansoni hypothetical protein 0.0068 0.0145 0.0871
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0019
Schistosoma mansoni methionyl-tRNA synthetase 0.0016 0.0015 0.0089
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0004 0.0004
Echinococcus granulosus lamin 0.0026 0.0042 0.0167
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0027 0.0384
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0023 0.0338
Brugia malayi calpain 7 0.0021 0.0028 0.0028
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.2912
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0028 0.2049
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.014
Loa Loa (eye worm) hypothetical protein 0.0049 0.0099 0.0099
Chlamydia trachomatis glycogen phosphorylase 0.013 0.0301 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0008 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0088 0.0531
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0028 0.2049
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0055 0.0112 0.0112
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0028 0.0112
Leishmania major kinesin, putative 0.0015 0.0012 0.0905
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0092 0.0206 0.124
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0081 0.1173
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0137 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.069 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0112 0.0112
Schistosoma mansoni chromobox protein 0.0011 0.0004 0.0027
Schistosoma mansoni chromobox protein 0.007 0.015 0.0904
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0296
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0066 0.0409
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0069 0.0418
Plasmodium falciparum tRNA import protein tRIP 0.0016 0.0015 0.1534
Trichomonas vaginalis esterase, putative 0.0036 0.0066 0.0955
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0092 0.0206 0.124
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.0301 0.4356
Schistosoma mansoni glycogen phosphorylase 0.013 0.0301 0.1812
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0066 0.0409
Schistosoma mansoni hypothetical protein 0.0055 0.0112 0.0674
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0046 0.0046
Schistosoma mansoni regulator of G protein signaling 0.001 0 0.0002
Echinococcus granulosus segment polarity protein dishevelled 0.001 0 0.0001
Brugia malayi hypothetical protein 0.0025 0.0038 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0015 0.1071
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0004 0.0027
Trypanosoma cruzi tyrosyl or methionyl-tRNA synthetase, putative 0.0016 0.0015 0.1071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0054 0.0325
Brugia malayi peptidase family M13 containing protein 0.0092 0.0206 0.0206
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0066 0.823
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0027 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0038 0.5089
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0013 0.0188
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.033 0.1989
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.069 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.002 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0074 0.1065
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0338
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0023 0.0128
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0027 0.1933
Trichomonas vaginalis hypothetical protein 0.0011 0.0004 0.0064
Brugia malayi calpain family protein 1 0.0056 0.0114 0.0114
Brugia malayi calpain 5 0.0015 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0016 0.0015 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.1933
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0056 0.0116 0.07
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0034
Schistosoma mansoni glycogen phosphorylase 0.0056 0.0116 0.0701
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.1128 0.4503
Echinococcus multilocularis Glycosyl transferase, family 35 0.013 0.0301 0.1812
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0066
Schistosoma mansoni lamin 0.0026 0.0042 0.0252
Echinococcus multilocularis chromobox protein 2 0.0011 0.0004 0.0027
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0071 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0066
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.015 0.015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0023 0.1699
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.047 0.5938
Echinococcus granulosus calpain 0.0021 0.0028 0.0112
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0028 0.2049
Trypanosoma cruzi kinesin, putative 0.0015 0.0012 0.0905
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0027 0.0106
Onchocerca volvulus Deterin homolog 0.0055 0.0112 0.1413
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0019 0.2399
Echinococcus multilocularis glycogen phosphorylase 0.013 0.0301 0.1812
Onchocerca volvulus 0.0056 0.0116 0.1467
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0027 0.0027
Onchocerca volvulus 0.0023 0.0034 0.0428
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0028 0.2049
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0015 0.1071
Echinococcus granulosus tm gpcr rhodopsin 0.0509 0.1244 0.4966
Trypanosoma cruzi tyrosyl-tRNA synthetase, putative 0.002 0.0026 0.1894
Onchocerca volvulus 0.0026 0.0042 0.0528
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Onchocerca volvulus 0.0056 0.0116 0.1467
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0056 0.0116 0.07

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.1 uM Inhibition of human liver glycogen phosphorylase a ChEMBL. 18434170

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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