Detailed information for compound 1023205

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 198.222 | Formula: C8H14N4O2
  • H donors: 4 H acceptors: 3 LogP: -2.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(CCCc1cnc([nH]1)N)N
  • InChi: 1S/C8H14N4O2/c9-6(7(13)14)3-1-2-5-4-11-8(10)12-5/h4,6H,1-3,9H2,(H,13,14)(H3,10,11,12)
  • InChiKey: KUOPJEUTHQURCW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0052 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Onchocerca volvulus 0.0033 0.0009 0.0007
Trypanosoma cruzi Kinesin-13 5, putative 0.0073 0.0171 1
Echinococcus multilocularis Sterile alpha motif type 0.0073 0.0171 0.0275
Schistosoma mansoni jumonji/arid domain-containing protein 0.0273 0.0985 0.0981
Echinococcus granulosus phd finger protein 10 0.0048 0.007 0.0107
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Brugia malayi Shank2E 0.0073 0.0171 0.0315
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0949 0.3737 0.6196
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0049 0.5
Trypanosoma brucei Ring finger domain/PHD-finger, putative 0.0048 0.007 0.2958
Echinococcus granulosus Sterile alpha motif type 0.0073 0.0171 0.0275
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0825 0.1557
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Echinococcus granulosus dnaJ subfamily B 0.0821 0.3215 0.5329
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0073 0.0171 0.0315
Echinococcus multilocularis PHD finger protein 14 0.0048 0.007 0.0107
Echinococcus multilocularis chromobox protein 1 0.0033 0.0009 0.0006
Plasmodium falciparum EELM2 domain-containing protein, putative 0.0048 0.007 0.2932
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0027 0.0037
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Loa Loa (eye worm) tnks protein 0.0073 0.0171 0.0315
Echinococcus granulosus chromobox protein 1 0.0033 0.0009 0.0006
Schistosoma mansoni chromobox protein 0.0033 0.0009 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0062 0.3283
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0106 0.0305 0.03
Onchocerca volvulus 0.0875 0.3436 0.6515
Echinococcus multilocularis phd finger protein 12 0.0048 0.007 0.0107
Brugia malayi PHD-finger family protein 0.0048 0.007 0.0123
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0073 0.0171 0.0315
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0821 0.3215 0.3212
Echinococcus granulosus sphingomyelin synthase protein 1 0.0073 0.0171 0.0275
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0033 0.0009 0.0004
Brugia malayi jmjC domain containing protein 0.0401 0.1504 0.2846
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0278 0.1005 0.1898
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0315
Onchocerca volvulus 0.0106 0.0305 0.0569
Onchocerca volvulus 0.0033 0.0009 0.0007
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0027 0.0037
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.007 0.0107
Onchocerca volvulus 0.0048 0.007 0.0123
Onchocerca volvulus 0.0048 0.007 0.0123
Schistosoma mansoni hypothetical protein 0.0048 0.007 0.0065
Schistosoma mansoni hypothetical protein 0.0033 0.0009 0.0004
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0048 0.007 0.0107
Echinococcus granulosus polyhomeotic protein 2 0.0073 0.0171 0.0275
Echinococcus granulosus Zinc finger DBF type 0.0048 0.007 0.0107
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0073 0.0171 0.0275
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0315
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0048 0.007 0.0107
Plasmodium vivax protein kinase, putative 0.0073 0.0171 0.7802
Brugia malayi Valyl-tRNA synthetase 0.0033 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0033 0.0009 0.0007
Loa Loa (eye worm) F/Y-rich family protein 0.0048 0.007 0.0123
Brugia malayi Cytochrome P450 family protein 0.0043 0.0049 0.0084
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0033 0.0009 0.0231
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0048 0.007 0.0107
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Echinococcus granulosus histone acetyltransferase MYST2 0.0278 0.1005 0.166
Echinococcus granulosus liprin alpha 2 0.0073 0.0171 0.0275
Echinococcus granulosus pdz domain containing protein 0.0073 0.0171 0.0275
Loa Loa (eye worm) hypothetical protein 0.0106 0.0305 0.0569
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0074 0.0173 0.0279
Loa Loa (eye worm) PHD-finger family protein 0.0048 0.007 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.007 0.3758
Onchocerca volvulus 0.0106 0.0305 0.0569
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0048 0.007 0.0107
Brugia malayi Bromodomain containing protein 0.0048 0.007 0.0123
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0318 0.8108
Brugia malayi SET domain containing protein 0.005 0.0075 0.0133
Echinococcus multilocularis polyhomeotic protein 2 0.0073 0.0171 0.0275
Schistosoma mansoni dpf3 0.0048 0.007 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.007 0.3758
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0033 0.0009 0.0004
Brugia malayi CXXC zinc finger family protein 0.0058 0.0108 0.0195
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0073 0.0171 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0049 0.0084
Echinococcus granulosus zinc finger protein 0.0048 0.007 0.0107
Giardia lamblia Kinesin-13 0.0073 0.0171 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Brugia malayi F/Y-rich N-terminus family protein 0.0063 0.0128 0.0234
Toxoplasma gondii hypothetical protein 0.0074 0.0175 0.4473
Brugia malayi PHD-finger family protein 0.0048 0.007 0.0123
Echinococcus granulosus chromobox protein 2 0.0572 0.22 0.3644
Loa Loa (eye worm) heterochromatin protein 1 0.0033 0.0009 0.0007
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.007 0.0065
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0049 0.0084
Brugia malayi Bromodomain associated family protein 0.0048 0.007 0.0123
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.1512 0.6028 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0062 0.3283
Echinococcus multilocularis chromobox protein 2 0.0572 0.22 0.3644
Echinococcus granulosus histone acetyltransferase myst3 0.0121 0.0368 0.0602
Loa Loa (eye worm) CHromoDomain protein family member 0.0082 0.0206 0.0381
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0027 0.0022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0048 0.007 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.007 0.3758
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0082 0.0206 0.0333
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0027 0.1137
Echinococcus multilocularis zinc finger protein 0.0048 0.007 0.0107
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0027 0.2449
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Brugia malayi Liprin-alpha 2 0.0073 0.0171 0.0315
Brugia malayi AIDA-1b 0.0073 0.0171 0.0315
Trypanosoma cruzi hypothetical protein 0.0073 0.0171 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0027 0.0037
Echinococcus granulosus PHD finger protein 14 0.0048 0.007 0.0107
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0048 0.007 0.0123
Trypanosoma cruzi Kinesin-13 5, putative 0.0073 0.0171 1
Brugia malayi cask-interacting protein 2 0.0073 0.0171 0.0315
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0082 0.0206 0.0333
Echinococcus multilocularis liprin alpha 2 0.0073 0.0171 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.007 0.3758
Trichomonas vaginalis inhibitor of growth, putative 0.0048 0.007 0.3758
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0315
Brugia malayi PHD-finger family protein 0.0048 0.007 0.0123
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0033 0.0009 0.0007
Toxoplasma gondii PLU-1 family protein 0.0127 0.0392 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0033 0.0009 0.0231
Echinococcus multilocularis pdz domain containing protein 0.0073 0.0171 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0171 1
Plasmodium vivax SNF2 family N-terminal domain containing protein 0.0048 0.007 0.2932
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0315
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0062 0.3283
Schistosoma mansoni Protein aveugle 0.0073 0.0171 0.0166
Brugia malayi PHD-finger family protein 0.0048 0.007 0.0123
Schistosoma mansoni spingomyelin synthetase-related 0.0073 0.0171 0.0166
Onchocerca volvulus 0.0106 0.0305 0.0569
Trichomonas vaginalis cgi-62, putative 0.0073 0.0171 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0084 0.0217 1
Plasmodium falciparum SNF2 helicase, putative 0.0048 0.007 0.2932
Brugia malayi SET domain containing protein 0.0035 0.0014 0.0017
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0027 0.0022
Schistosoma mansoni myst histone acetyltransferase 0.0048 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0315
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.007 0.1783
Echinococcus granulosus liprin alpha 2 0.0073 0.0171 0.0275
Onchocerca volvulus 0.0035 0.0014 0.0017
Loa Loa (eye worm) PHD-finger family protein 0.0048 0.007 0.0123
Brugia malayi Protein cec-1. 0.0033 0.0009 0.0007
Schistosoma mansoni fyve-containing 0.0048 0.007 0.0065
Onchocerca volvulus 0.0048 0.007 0.0123
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0048 0.007 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.007 0.3758
Onchocerca volvulus 0.0073 0.0171 0.0315
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0034 0.1521
Echinococcus multilocularis histone acetyltransferase myst4 0.0048 0.007 0.0107
Loa Loa (eye worm) helicase 0.0033 0.0009 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0401 0.1504 0.2846
Schistosoma mansoni bromodomain containing protein 0.0048 0.007 0.0065
Schistosoma mansoni cpg binding protein 0.0106 0.0305 0.03
Toxoplasma gondii AP2 domain transcription factor AP2VIIa-7 0.0048 0.007 0.1783
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Echinococcus multilocularis polycomb protein SCMH1 0.0771 0.3011 0.499
Echinococcus granulosus remodeling and spacing factor 1 0.0048 0.007 0.0107
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0949 0.3737 0.6196
Brugia malayi bicaudal-C 0.0073 0.0171 0.0315
Echinococcus multilocularis remodeling and spacing factor 1 0.0048 0.007 0.0107
Brugia malayi Cation transporter family protein 0.0106 0.0305 0.0569
Echinococcus granulosus Chromobox protein 3 0.0033 0.0009 0.0006
Brugia malayi Sphingomyelin synthase-related 1 0.0073 0.0171 0.0315
Brugia malayi hypothetical protein 0.0033 0.0009 0.0007
Leishmania major cytochrome p450-like protein 0.0043 0.0049 1
Echinococcus granulosus polycomb protein SCMH1 0.0771 0.3011 0.499
Echinococcus multilocularis liprin alpha 2 0.0073 0.0171 0.0275
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0334 0.1234 0.204
Onchocerca volvulus 0.0073 0.0171 0.0315
Schistosoma mansoni cpg binding protein 0.0106 0.0305 0.03
Schistosoma mansoni zinc finger protein 0.0048 0.007 0.0065
Schistosoma mansoni cpg binding protein 0.0058 0.0108 0.0103
Onchocerca volvulus 0.005 0.0075 0.0133
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0073 0.0171 1
Schistosoma mansoni chromobox protein 0.0033 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0315
Echinococcus multilocularis uro adherence factor A 0.0048 0.007 0.0107
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0073 0.0171 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.007 0.3758
Onchocerca volvulus Tankyrase homolog 0.0073 0.0171 0.0315
Echinococcus granulosus chromobox protein 1 0.0033 0.0009 0.0006
Schistosoma mansoni PHD zinc finger protein XAP135-related 0.0048 0.007 0.0065
Onchocerca volvulus 0.0073 0.0171 0.0315
Onchocerca volvulus 0.0073 0.0171 0.0315
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0073 0.0171 0.0275
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Brugia malayi coiled-coil like protein 1 0.0073 0.0171 0.0315
Schistosoma mansoni hepatitis B virus X associated protein hbxa 0.0048 0.007 0.0065
Plasmodium falciparum zinc finger protein, putative 0.0052 0.0084 0.3622
Brugia malayi jmjC domain containing protein 0.0074 0.0173 0.0319
Echinococcus multilocularis Chromobox protein 3 0.0033 0.0009 0.0006
Brugia malayi Heterochromatin protein 1 0.0033 0.0009 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0055 0.0094
Echinococcus granulosus lysine specific demethylase 5B 0.0048 0.007 0.0107
Trypanosoma cruzi Ring finger domain/PHD-finger, putative 0.0048 0.007 0.2958
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.007 0.1783
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0108 0.0195
Onchocerca volvulus 0.0048 0.007 0.0123
Brugia malayi hypothetical protein 0.0073 0.0171 0.0315
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0062 0.3283
Schistosoma mansoni hypothetical protein 0.0073 0.0171 0.0166
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0173 0.0168
Schistosoma mansoni jumonji/arid domain-containing protein 0.0273 0.0985 0.0981
Brugia malayi chromobox protein homolog 3 0.0033 0.0009 0.0007
Schistosoma mansoni DNAj-like protein 0.0073 0.0171 0.0166
Echinococcus multilocularis lysine specific demethylase 5B 0.0048 0.007 0.0107
Echinococcus multilocularis dnaJ subfamily B 0.0821 0.3215 0.5329
Brugia malayi hypothetical protein 0.0073 0.0171 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.1137
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0033 0.0009 0.0006
Schistosoma mansoni myst-related protein 0.0052 0.0084 0.0079
Brugia malayi Associated with TFs and helicases family protein 0.0033 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.007 0.3758
Echinococcus multilocularis cpg binding protein 0.0106 0.0305 0.0497
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0074 0.0173 0.0279
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0049 0.1524
Schistosoma mansoni Protein aveugle 0.0073 0.0171 0.0166
Loa Loa (eye worm) AIDA-1b 0.0073 0.0171 0.0315
Brugia malayi hypothetical protein 0.0048 0.007 0.0123
Loa Loa (eye worm) MBCTL1 0.0278 0.1005 0.1898
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0106 0.0305 0.03
Trypanosoma cruzi Ring finger domain/PHD-finger, putative 0.0048 0.007 0.2958
Schistosoma mansoni zinc finger protein 0.0048 0.007 0.0065
Schistosoma mansoni hypothetical protein 0.0048 0.007 0.0065
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.007 0.1783
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.1116 0.4417 0.4414
Brugia malayi mbt repeat family protein 0.0802 0.3138 0.595
Brugia malayi PHD-finger family protein 0.0048 0.007 0.0123
Onchocerca volvulus 0.0073 0.0171 0.0315
Schistosoma mansoni myst-related protein 0.0052 0.0084 0.0079
Brugia malayi M-phase phosphoprotein, mpp8 0.0033 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0315
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0073 0.0171 0.0275
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0027 0.1137
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0825 0.1557
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0049 0.1524
Echinococcus multilocularis lysine specific demethylase 5A 0.0225 0.0789 0.1301
Onchocerca volvulus 0.0058 0.0108 0.0195
Schistosoma mansoni bromodomain containing protein 0.0048 0.007 0.0065
Schistosoma mansoni sex comb on midleg homolog 0.0771 0.3011 0.3007
Echinococcus granulosus lysine specific demethylase 5A 0.0273 0.0985 0.1627
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0082 0.0206 0.0201
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0033 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0106 0.0305 0.0569
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0027 0.0037
Echinococcus multilocularis histone acetyltransferase myst3 0.0121 0.0368 0.0602
Brugia malayi hypothetical protein 0.0048 0.007 0.0123
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0049 0.1524
Schistosoma mansoni sex comb on midleg homolog 0.0771 0.3011 0.3007
Plasmodium vivax hypothetical protein, conserved 0.0048 0.007 0.2932
Schistosoma mansoni SET domain protein 0.005 0.0075 0.007
Brugia malayi CHD4 protein 0.0082 0.0206 0.0381
Echinococcus granulosus cpg binding protein 0.0106 0.0305 0.0497
Plasmodium vivax JmjC domain containing protein 0.0084 0.0217 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0094 0.0255 0.6515
Schistosoma mansoni lip-related protein (liprin) alpha 0.0073 0.0171 0.0166
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0073 0.0171 1
Echinococcus granulosus histone acetyltransferase myst4 0.0048 0.007 0.0107
Schistosoma mansoni requim req/dpf2 0.0048 0.007 0.0065
Echinococcus multilocularis SAM and MBT domain containing protein 0.1116 0.4417 0.7325
Echinococcus multilocularis Chromo domain 0.0033 0.0009 0.0006
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0027 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0062 0.3283
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0278 0.1005 0.166
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0027 0.0042
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0073 0.0171 1
Schistosoma mansoni zinc finger protein 0.0048 0.007 0.0065
Schistosoma mansoni hypothetical protein 0.0048 0.007 0.0065
Plasmodium falciparum histone-lysine N-methyltransferase, H3 lysine-4 specific 0.0048 0.007 0.2932
Echinococcus multilocularis Sterile alpha motif SAM 0.0073 0.0171 0.0275
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0278 0.1005 0.1898
Echinococcus multilocularis Zinc finger, DBF type 0.0048 0.007 0.0107
Schistosoma mansoni hypothetical protein 0.0048 0.007 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0371 0.0366
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0033 0.0009 0.0006
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.1326 0.5271 1
Schistosoma mansoni chromobox protein 0.0572 0.22 0.2196
Echinococcus multilocularis histone acetyltransferase MYST2 0.0278 0.1005 0.166
Schistosoma mansoni myelin transcription factor 1 myt1 0.0278 0.1005 0.1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.007 0.3758
Echinococcus granulosus uro adherence factor A 0.0048 0.007 0.0107
Onchocerca volvulus 0.0073 0.0171 0.0315
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0278 0.1005 0.166
Brugia malayi mbt repeat family protein 0.1326 0.5271 1
Schistosoma mansoni phd finger protein 0.0121 0.0368 0.0363
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Loa Loa (eye worm) mbt repeat family protein 0.0802 0.3138 0.595
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.007 0.1783
Schistosoma mansoni hypothetical protein 0.0949 0.3737 0.3734
Echinococcus granulosus phd finger protein 12 0.0048 0.007 0.0107
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0315
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0033 0.0009 0.0007
Schistosoma mansoni chromobox protein 0.0033 0.0009 0.0004
Schistosoma mansoni hypothetical protein 0.0073 0.0171 0.0166
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0038 0.1762
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Toxoplasma gondii SWI2/SNF2-containing PHD finger protein 0.0048 0.007 0.1783
Loa Loa (eye worm) hypothetical protein 0.0091 0.0244 0.0453
Loa Loa (eye worm) hypothetical protein 0.1326 0.5271 1
Loa Loa (eye worm) CYP4Cod1 0.0043 0.0049 0.0084
Echinococcus granulosus SAM and MBT domain containing protein 0.1116 0.4417 0.7325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0062 0.3283
Echinococcus granulosus endonuclease exonuclease phosphatase 0.1512 0.6028 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Echinococcus granulosus Chromo domain 0.0033 0.0009 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0048 0.007 0.0107
Echinococcus granulosus Sterile alpha motif SAM 0.0073 0.0171 0.0275
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0073 0.0171 0.0166
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0027 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.1762
Brugia malayi Cytochrome P450 family protein 0.0043 0.0049 0.0084
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0048 0.007 0.0107
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0062 0.3283
Echinococcus multilocularis phd finger protein 10 0.0048 0.007 0.0107
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.007 0.0107
Schistosoma mansoni hypothetical protein 0.0048 0.007 0.0065
Echinococcus multilocularis chromobox protein 1 0.0033 0.0009 0.0006
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0033 0.0009 0.0231
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0123
Schistosoma mansoni phd finger protein 0.0048 0.007 0.0065
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0334 0.1234 0.204
Brugia malayi Cytochrome P450 family protein 0.0045 0.0055 0.0094
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0073 0.0171 0.0275
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0062 0.3283
Brugia malayi PHD-finger family protein 0.0048 0.007 0.0123
Schistosoma mansoni polyhomeotic 0.0073 0.0171 0.0166

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 65 uM Inhibition rat recombinant nNOS ChEMBL. 20441173
IC50 (binding) = 65 uM Inhibition of mouse recombinant iNOS ChEMBL. 20441173
Ki (binding) > 80000 uM Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay ChEMBL. 20441173

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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