Detailed information for compound 1032596

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 425.65 | Formula: C27H43N3O
  • H donors: 1 H acceptors: 1 LogP: 6.48 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCN1CC[C@H]([C@H](C1)CCN)CCCc1ccnc2c1cc(OC)cc2
  • InChi: 1S/C27H43N3O/c1-3-4-5-6-7-18-30-19-15-22(24(21-30)13-16-28)9-8-10-23-14-17-29-27-12-11-25(31-2)20-26(23)27/h11-12,14,17,20,22,24H,3-10,13,15-16,18-19,21,28H2,1-2H3/t22-,24+/m1/s1
  • InChiKey: IFVNZFJEXZHFER-VWNXMTODSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0444 0.0759 0.1982
Echinococcus granulosus tumor protein p63 0.1378 0.2412 0.2411
Loa Loa (eye worm) hypothetical protein 0.0082 0.012 0.1398
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0088 0.0087
Mycobacterium ulcerans hypothetical protein 0.0035 0.0037 0.0088
Echinococcus granulosus tar DNA binding protein 0.0064 0.0088 0.0087
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0038 0.1292
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0054 0.0628
Loa Loa (eye worm) programmed cell death 8 0.0016 0.0003 0.0035
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0016 0.0003 0.0066
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0037 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0021 0.0519
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0005 0.0005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0037 0.0036
Plasmodium falciparum thioredoxin reductase 0.0175 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.003 0.035
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0037 0.0907
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0037 0.0088
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0061 0.0082 0.0206
Schistosoma mansoni ferritin 0.0017 0.0005 0.0004
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0016 0.0003 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0061 0.0082 0.2851
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0003 0.0048
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0016 0.0003 0.0066
Trypanosoma brucei NADH dehydrogenase 0.0016 0.0003 0.0066
Plasmodium falciparum thioredoxin reductase 0.0061 0.0082 0.2803
Mycobacterium tuberculosis Probable reductase 0.0399 0.0681 0.1775
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0175 0.0284 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0932
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0003 0.0066
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.0029
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0054 0.3003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0827
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0003 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0932
Trichomonas vaginalis mercuric reductase, putative 0.0061 0.0082 0.2061
Echinococcus granulosus GPCR family 2 0.0031 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0099 0.015 0.1749
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0061 0.0082 0.0206
Schistosoma mansoni survival motor neuron protein 0.0102 0.0155 0.0153
Trypanosoma brucei trypanothione reductase 0.0175 0.0284 1
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0037 0.0088
Brugia malayi beta-lactamase 0.0035 0.0037 0.0427
Trypanosoma cruzi NADH dehydrogenase, putative 0.0016 0.0003 0.0066
Entamoeba histolytica hypothetical protein 0.0112 0.0172 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0399 0.0681 0.1775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0932
Loa Loa (eye worm) RNA binding protein 0.0064 0.0088 0.1028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0017 0.0415
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0054 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0037 0.1196
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.003 0.0029
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0004
Leishmania major hypothetical protein, conserved 0.0035 0.0037 0.1255
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0082 0.2851
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0037 0.1255
Plasmodium falciparum glutathione reductase 0.0061 0.0082 0.2803
Echinococcus granulosus intermediate filament protein 0.0027 0.0022 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.003 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0037 0.0907
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0531
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0025 0.1847
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0025 0.0768
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0037 0.0427
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0005 0.0156
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 1
Echinococcus multilocularis tumor protein p63 0.1378 0.2412 0.2411
Brugia malayi Thioredoxin reductase 0.0175 0.0284 0.3314
Brugia malayi MH2 domain containing protein 0.0017 0.0005 0.0056
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0393 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.0658
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0061 0.0082 0.2851
Trichomonas vaginalis esterase, putative 0.0035 0.0037 0.0907
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0016 0.0003 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0061 0.0082 0.2851
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0037 0.0088
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0016 0.0003 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0061 0.0082 0.2851
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.012 0.0119
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0054 0.1863
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0427
Echinococcus multilocularis microtubule associated protein 2 0.5669 1 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0048
Trypanosoma cruzi trypanothione reductase, putative 0.0175 0.0284 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0037 0.0088
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0016 0.0003 0.0002
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0016 0.0003 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0175 0.0284 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0027 0.0026
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0399 0.0681 0.1775
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0061 0.0082 0.2851
Brugia malayi TAR-binding protein 0.0064 0.0088 0.1028
Brugia malayi intermediate filament protein 0.0027 0.0022 0.0258
Trichomonas vaginalis glutathione reductase, putative 0.0061 0.0082 0.2061
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0028 0.068
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0037 0.1255
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0005 0.0004
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0016 0.0003 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0082 0.2851
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0827
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0003 0.0066
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.003 0.035
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.007 0.0175
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0094 0.1102
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0061 0.0082 0.2803
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.007 0.0175
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.012 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0082 0.2851
Loa Loa (eye worm) beta-lactamase 0.0035 0.0037 0.0427
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0172 0.0171
Brugia malayi MH1 domain containing protein 0.0017 0.0005 0.0056
Toxoplasma gondii thioredoxin reductase 0.0175 0.0284 1
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0005 0.0005
Brugia malayi Pre-SET motif family protein 0.0208 0.0342 0.3988
Brugia malayi hypothetical protein 0.0499 0.0857 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0001 0.0013
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0016 0.0003 0.0066
Leishmania major hypothetical protein, conserved 0.0016 0.0003 0.0066
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0037 0.0088
Trichomonas vaginalis glutamate synthase, putative 0.0016 0.0003 0.0048
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0088 0.1028
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0005 0.0156
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0016 0.0003 0.0035
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0016 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0112 0.0172 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0427
Brugia malayi hypothetical protein 0.0017 0.0004 0.0043
Loa Loa (eye worm) Smad1 0.0017 0.0005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0427
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0022 0.0258
Loa Loa (eye worm) hypothetical protein 0.0068 0.0094 0.1102
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0003 0.0066
Brugia malayi beta-lactamase family protein 0.0035 0.0037 0.0427
Loa Loa (eye worm) glutathione reductase 0.0175 0.0284 0.3314
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0016 0.0003 0.0066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0176 0.0286 0.0285
Onchocerca volvulus 0.0027 0.0022 0.0491
Toxoplasma gondii hypothetical protein 0.0028 0.0025 0.0768
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0016 0.0003 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0017 0.0415
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0037 0.0427
Schistosoma mansoni cellular tumor antigen P53 0.0202 0.0331 0.033
Schistosoma mansoni ferritin light chain 0.0017 0.0005 0.0004
Mycobacterium ulcerans lipase LipD 0.0035 0.0037 0.0088
Mycobacterium ulcerans transcriptional regulator 0.2179 0.3828 1
Schistosoma mansoni ferritin light chain 0.0017 0.0005 0.0004
Echinococcus granulosus lamin 0.0027 0.0022 0.0021
Trichomonas vaginalis apoptosis inducing factor, putative 0.0016 0.0003 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0258
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0022 0.0258
Entamoeba histolytica hypothetical protein 0.0112 0.0172 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0061 0.0082 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0399 0.0681 0.1772
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0061 0.0082 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0037 0.0907
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.02 0.0199
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0172 0.0171
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0025 0.0024
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0016 0.0003 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0082 0.2851
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0444 0.0759 0.1982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0017 0.0413
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0088 0.1028
Plasmodium vivax SET domain protein, putative 0.003 0.0027 0.0861
Loa Loa (eye worm) thioredoxin reductase 0.0175 0.0284 0.3314
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0061 0.0082 0.2851
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0061 0.0082 0.2851
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0088 0.0087
Entamoeba histolytica hypothetical protein 0.0112 0.0172 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0054 0.1863
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0005 0.0005
Echinococcus multilocularis lamin 0.0027 0.0022 0.0021
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0003 0.0066
Echinococcus granulosus smad 0.0017 0.0005 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0531
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.015 0.1749
Echinococcus multilocularis lamin dm0 0.0027 0.0022 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0037 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0037 0.0907
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.015 0.1749
Schistosoma mansoni microtubule-associated protein tau 0.5669 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0016 0.0003 0.0002
Leishmania major trypanothione reductase 0.0175 0.0284 1
Brugia malayi Smad1 0.0017 0.0005 0.0056
Schistosoma mansoni ferritin 0.0017 0.0005 0.0004
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2175 0.382 1
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0003 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0827
Schistosoma mansoni hypothetical protein 0.0068 0.0094 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.0658
Schistosoma mansoni glutamate synthase 0.0016 0.0003 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0444 0.0759 0.1982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0827
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0038 0.1292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0021 0.0519
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0427
Echinococcus granulosus ferritin 0.0017 0.0005 0.0004
Onchocerca volvulus 0.0035 0.0037 0.0863
Leishmania major hypothetical protein, conserved 0.0016 0.0003 0.0066
Schistosoma mansoni hypothetical protein 0.0128 0.02 0.0199
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0054 0.1863
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0025 0.0768
Schistosoma mansoni thyroid hormone receptor 0.0138 0.0218 0.0217
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0061 0.0082 0.2803
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0371 0.0965
Plasmodium vivax glutathione reductase, putative 0.0175 0.0284 1
Brugia malayi Pre-SET motif family protein 0.003 0.0027 0.0317
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0005 0.0005
Schistosoma mansoni glutamate synthase 0.0016 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0427
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0061 0.0082 0.2803
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0027 0.0026
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0025 0.0056
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0037 0.0088
Mycobacterium ulcerans beta-lactamase 0.0035 0.0037 0.0088
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0016 0.0003 0.0048
Schistosoma mansoni hypothetical protein 0.0102 0.0155 0.0153
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0005 0.0004
Brugia malayi beta-lactamase family protein 0.0035 0.0037 0.0427
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0003 0.0048
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0054 0.0053
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 1
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.007 0.0069
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0016 0.0003 0.0002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.012 0.4156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0054 0.1347
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0444 0.0759 0.1978
Loa Loa (eye worm) hypothetical protein 0.003 0.0027 0.0317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0427
Schistosoma mansoni lamin 0.0027 0.0022 0.0021
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.0419 0.4888
Schistosoma mansoni intermediate filament proteins 0.0027 0.0022 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0531
Echinococcus multilocularis GPCR, family 2 0.0031 0.003 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.0419 0.4888
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.015 0.1749
Schistosoma mansoni sulfide quinone reductase 0.0016 0.0003 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.007 0.0175
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0061 0.0082 0.2851
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0155 0.1803
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0248
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0399 0.0681 0.1775
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0088 0.0087
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0016 0.0003 0.0066
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0172 0.0171
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.0029
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0003 0.0066
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0061 0.0082 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0932
Brugia malayi MH2 domain containing protein 0.0251 0.0419 0.4888
Toxoplasma gondii ABC1 family protein 0.0035 0.0037 0.1196
Echinococcus granulosus lamin dm0 0.0027 0.0022 0.0021
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0061 0.0082 0.2803
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0061 0.0082 0.0206
Mycobacterium tuberculosis Probable dehydrogenase 0.0399 0.0681 0.1775
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0037 0.1255
Onchocerca volvulus 0.0102 0.0155 0.389
Echinococcus granulosus expressed protein 0.0017 0.0005 0.0004
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0003 0.0066
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0012 0.0386
Schistosoma mansoni ferritin 0.0017 0.0005 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0027 0.0861
Trichomonas vaginalis ferritin, putative 0.0017 0.0005 0.0094
Giardia lamblia GTOR 0.0045 0.0054 0.6452
Mycobacterium tuberculosis Conserved protein 0.0035 0.0037 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0017 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0017 0.0415
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0005 0.0004
Brugia malayi glutathione reductase 0.0175 0.0284 0.3314
Echinococcus granulosus survival motor neuron protein 1 0.0499 0.0857 0.0856
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0061 0.0082 0.2851
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0004
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0005 0.0056
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0061 0.0082 0.6746
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0016 0.0003 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0037 0.0036
Mycobacterium ulcerans TetR family transcriptional regulator 0.2179 0.3828 1
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2179 0.3828 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0037 0.0088
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0005 0.0056
Brugia malayi hypothetical protein 0.0026 0.002 0.023
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0003 0.0048
Brugia malayi glutamate synthase 0.0016 0.0003 0.0035
Onchocerca volvulus 0.0202 0.0331 0.8426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0054 0.1347
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0022 0.0258
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0061 0.0082 0.2803
Echinococcus multilocularis smad 0.0017 0.0005 0.0004
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0016 0.0003 0.0002
Brugia malayi hypothetical protein 0.0112 0.0172 0.201
Leishmania major hypothetical protein, conserved 0.0016 0.0003 0.0066
Schistosoma mansoni Smad4 0.0017 0.0005 0.0004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0016 0.0003 0.0035
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0003 0.0048
Trichomonas vaginalis glutamate synthase, putative 0.0016 0.0003 0.0048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0054 0.0628
Brugia malayi RNA binding protein 0.0064 0.0088 0.1028
Entamoeba histolytica hypothetical protein 0.0112 0.0172 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0061 0.0082 0.0206
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.02 0.0199
Schistosoma mansoni apoferritin-2 0.0017 0.0005 0.0004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0054 0.1863
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0082 0.2851
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0016 0.0003 0.0002
Schistosoma mansoni ferritin 0.0017 0.0005 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0037 0.0907
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0088 0.1028
Onchocerca volvulus 0.0236 0.0393 1
Echinococcus multilocularis glutamate synthase 0.0016 0.0003 0.0002
Trypanosoma cruzi NADH dehydrogenase, putative 0.0016 0.0003 0.0066
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0054 0.0053
Echinococcus multilocularis musashi 0.0027 0.0022 0.0021
Leishmania major NADH dehydrogenase, putative 0.0016 0.0003 0.0066
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0045 0.0053 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0054 0.1347
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0045 0.0053 0.0622
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0054 0.3003
Schistosoma mansoni sulfide quinone reductase 0.0016 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0827
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0342 0.3988
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0003 0.0048
Toxoplasma gondii NADPH-glutathione reductase 0.0061 0.0082 0.2803
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0016 0.0003 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0026 0.0636
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0932
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0005 0.0004
Schistosoma mansoni smad 0.0017 0.0005 0.0004
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 0.0305
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2179 0.3828 1
Onchocerca volvulus 0.0035 0.0037 0.0863
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.0029
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0001 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0037 0.0036
Brugia malayi MH2 domain containing protein 0.0017 0.0005 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0017 0.0413
Loa Loa (eye worm) hypothetical protein 0.0499 0.0857 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0061 0.0082 0.0954
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.002 0.0658
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0037 0.0088
Mycobacterium tuberculosis Conserved protein 0.0035 0.0037 0.0088
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0054 0.1863
Leishmania major hypothetical protein, conserved 0.0026 0.002 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0827
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0016 0.0003 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0827
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0061 0.0082 0.6746
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0016 0.0003 0.0002
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0007 0.0224
Echinococcus multilocularis expressed protein 0.0017 0.0005 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0027 0.0026
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0061 0.0082 0.6746
Schistosoma mansoni glutamate synthase 0.0016 0.0003 0.0002
Echinococcus granulosus Smad4 0.0017 0.0005 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.003 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.105
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.012 0.4156
Mycobacterium tuberculosis Conserved protein 0.0035 0.0037 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0088 0.0087
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0054 0.1863
Echinococcus multilocularis Smad4 0.0017 0.0005 0.0004
Brugia malayi Latrophilin receptor protein 2 0.0031 0.003 0.035
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0027 0.0026
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0037 0.0088
Loa Loa (eye worm) hypothetical protein 0.0202 0.0331 0.3865
Echinococcus multilocularis survival motor neuron protein 1 0.0499 0.0857 0.0856
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.0218 0.0217
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0005 0.0004
Onchocerca volvulus 0.0027 0.0022 0.0491
Schistosoma mansoni disulfide oxidoreductase 0.0016 0.0003 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0061 0.0082 0.2851
Schistosoma mansoni lamin 0.0027 0.0022 0.0021
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 0.0305
Schistosoma mansoni apoferritin-2 0.0017 0.0005 0.0004
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 0.4156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0017 0.0415
Mycobacterium leprae Probable lipase LipE 0.0035 0.0037 0.0088
Treponema pallidum NADH oxidase 0.0061 0.0082 0.6746
Echinococcus granulosus thioredoxin glutathione reductase 0.0176 0.0286 0.0285
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0088 0.0087
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.012 0.4156
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0399 0.0681 0.1775
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0082 0.2851
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.002 0.0596
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0033 0.1086
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.002 0.0596
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.012 0.0305
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.002 0.0596
Brugia malayi Probable ClpP-like protease 0.0082 0.012 0.1398
Plasmodium falciparum glutathione reductase 0.0175 0.0284 1
Onchocerca volvulus 0.0035 0.0037 0.0863
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0016 0.0003 0.0066
Brugia malayi MH1 domain containing protein 0.0017 0.0005 0.0056
Echinococcus granulosus glutamate synthase 0.0016 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0061 0.0082 0.2851
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.002 0.0596
Schistosoma mansoni thyroid hormone receptor 0.0138 0.0218 0.0217
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0061 0.0082 0.0081
Onchocerca volvulus 0.003 0.0027 0.0621
Echinococcus multilocularis ferritin 0.0017 0.0005 0.0004
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0038 0.1292
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.003 0.0029
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.007 0.0069
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.012 0.0119

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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