Detailed information for compound 1033088

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.934 | Formula: C21H30ClN3O3
  • H donors: 3 H acceptors: 2 LogP: 3.65 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNCCCOc1ccc2c(c1)nc1c(c2)ccc(c1)OCCCNC.Cl.O
  • InChi: 1S/C21H27N3O2.ClH.H2O/c1-22-9-3-11-25-18-7-5-16-13-17-6-8-19(26-12-4-10-23-2)15-21(17)24-20(16)14-18;;/h5-8,13-15,22-23H,3-4,9-12H2,1-2H3;1H;1H2
  • InChiKey: BWRKKGQCCNPTJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Trypsin family protein 0.0019 0.0269 0.045
Plasmodium falciparum thioredoxin reductase 0.0042 0.0812 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0212 0.0957
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0212 0.0212
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0149 0.1713
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Echinococcus multilocularis slit 2 protein 0.004 0.0776 0.0776
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0194 0.0194
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0152 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0549 0.0701
Echinococcus granulosus glycoprotein Antigen 5 0.0019 0.0269 0.0269
Brugia malayi Calcitonin receptor-like protein seb-1 0.0211 0.4925 0.8248
Echinococcus granulosus neurogenic locus notch protein 4 0.004 0.0776 0.0776
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0152 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.079 0.1328
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0157 0.0157
Brugia malayi Trypsin family protein 0.0019 0.0269 0.045
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0549 0.0549
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0549 0.0701
Brugia malayi EGF-like domain containing protein 0.004 0.0776 0.1299
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0212 0.0356
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0269 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0212 0.09
Loa Loa (eye worm) hypothetical protein 0.0031 0.0549 0.0701
Brugia malayi EGF-like domain containing protein 0.004 0.0776 0.1299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.065 0.1093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0234 0.0384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0549 0.0701
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0234 0.0384
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0549 0.0549
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0212 0.0881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0595 0.1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0549 0.092
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0212 0.09
Echinococcus granulosus dna polymerase kappa 0.0021 0.0315 0.0315
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0315 0.6218
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0152 0.0194
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0416 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0315 0.0528
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0315 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0595 0.1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0376 0.0633
Onchocerca volvulus 0.0031 0.0549 0.0686
Brugia malayi nuclear receptor RXR 0.0015 0.0152 0.0254
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0351 0.4039
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.026 0.1669
Echinococcus multilocularis importin subunit beta 1 0.0031 0.055 0.055
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.2113 0.8837
Trypanosoma brucei trypanothione reductase 0.0042 0.0812 0.9342
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.142 0.142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0549 0.0701
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.214 0.214
Onchocerca volvulus Slit protein homolog 0.004 0.0776 0.1076
Loa Loa (eye worm) hypothetical protein 0.0116 0.2602 0.3321
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0315 0.053
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0269 0.0269
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.079 0.908
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0315 0.0402
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0056 0.0093
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0212 0.0212
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0212 0.0957
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0549 0.0686
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0826 0.0826
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0315 0.3623
Schistosoma mansoni nuclear receptor 0.0015 0.0152 0.0152
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0152 0.0152
Brugia malayi Cell death protein 3 precursor 0.0067 0.1411 0.2362
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0586 0.0586
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0351 0.0588
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0149 0.1713
Echinococcus granulosus neural cadherin 0.004 0.0776 0.0776
Onchocerca volvulus 0.004 0.0776 0.1076
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.087 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0019 0.0269 0.0269
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0157 0.1803
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0549 0.0549
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0152 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0375 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0157 0.0264
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0095 0.2113 0.8678
Schistosoma mansoni tar DNA-binding protein 0.02 0.465 0.465
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2646 0.3378
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0033 0.0586 0.0748
Brugia malayi Latrophilin receptor protein 2 0.0067 0.142 0.2377
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0549 0.092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0149 0.1713
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0408 0.0685
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0331 0.7835 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0416 0.1625
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0004 0.0004
Brugia malayi RNA binding protein 0.02 0.465 0.7786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0549 0.0701
Loa Loa (eye worm) hypothetical protein 0.0031 0.0549 0.0701
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.214 0.214
Trichomonas vaginalis set domain proteins, putative 0.0253 0.5947 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0376 0.0633
Loa Loa (eye worm) hypothetical protein 0.0067 0.1411 0.1801
Echinococcus multilocularis neurogenic locus protein delta 0.004 0.0776 0.0776
Brugia malayi Cadherin domain containing protein 0.004 0.0776 0.1299
Loa Loa (eye worm) hypothetical protein 0.0144 0.3303 0.4215
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0152 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0269 0.0343
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0004 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.142 0.2377
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0549 0.0549
Brugia malayi isocitrate dehydrogenase 0.0017 0.0212 0.0356
Echinococcus granulosus transmembrane protease serine 3 0.0019 0.0269 0.0269
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0416 0.0697
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0549 0.092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0549 0.0549
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Loa Loa (eye worm) hypothetical protein 0.0106 0.2362 0.3015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0085 0.0143
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0549 0.0549
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.087 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0549 0.0549
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0416 1
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0549 0.0549
Echinococcus multilocularis dna polymerase eta 0.0021 0.0315 0.0315
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.079 0.1328
Loa Loa (eye worm) trypsin family protein 0.0019 0.0269 0.0343
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0416 0.0697
Echinococcus multilocularis neurogenic locus notch protein 0.004 0.0776 0.0776
Giardia lamblia High cysteine protein 0.004 0.0776 0.8696
Plasmodium falciparum glutathione reductase 0.0042 0.0812 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.079 0.079
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0549 0.092
Brugia malayi glutathione reductase 0.0042 0.0812 0.1361
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0149 0.0631
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.087 0.087
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0351 0.0448
Schistosoma mansoni hypothetical protein 0.0052 0.1057 0.1057
Echinococcus granulosus protein jagged 2 0.004 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Entamoeba histolytica Ran family GTPase 0.0023 0.0351 0.1372
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0549 0.0549
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0315 0.0315
Toxoplasma gondii EGF family domain-containing protein 0.004 0.0776 0.3284
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0514 0.0655
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0586 0.0586
Brugia malayi conserved hypotetical protein 0.0015 0.0152 0.0254
Echinococcus granulosus transcription factor eb 0.0116 0.2616 0.2616
Echinococcus multilocularis protein jagged 1 0.004 0.0776 0.0776
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Echinococcus multilocularis GPCR, family 2 0.0067 0.142 0.142
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0152 0.0152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0149 0.1713
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.026 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0438 0.0737
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0044 0.0074
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0549 0.092
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0351 0.4039
Brugia malayi Calcium binding EGF domain containing protein 0.004 0.0776 0.1299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0157 0.0264
Onchocerca volvulus Neurogenic locus notch homolog 0.004 0.0776 0.1076
Brugia malayi notch-like transmembrane receptor 0.004 0.0776 0.1299
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0586 0.248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0152 0.0152
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0212 0.0286
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0304 0.35
Loa Loa (eye worm) hypothetical protein 0.0019 0.026 0.0331
Brugia malayi hypothetical protein 0.0016 0.0194 0.0326
Loa Loa (eye worm) hypothetical protein 0.0159 0.3666 0.4679
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0408 0.0685
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0149 0.1713
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0812 0.2985
Onchocerca volvulus 0.0026 0.0416 0.0456
Plasmodium falciparum importin beta, putative 0.0031 0.055 0.6045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0549 0.0701
Loa Loa (eye worm) hypothetical protein 0.0019 0.026 0.0331
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0269 0.0269
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0549 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0438 0.0737
Brugia malayi nuclear receptor RXR 0.0016 0.0194 0.0326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.214 0.214
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0812 0.9342
Echinococcus granulosus neurogenic locus notch protein 0.004 0.0776 0.0776
Treponema pallidum NADH oxidase 0.0015 0.0149 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.026 0.1669
Onchocerca volvulus 0.004 0.0776 0.1076
Brugia malayi EGF-like domain containing protein 0.004 0.0776 0.1299
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0031 0.0549 0.0701
Echinococcus granulosus protein jagged 1 0.004 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0416 0.3707
Echinococcus multilocularis apoptotic protease activating factor 1 0.0067 0.1411 0.1411
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.1057 0.1769
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0152 0.0194
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0315 0.0315
Loa Loa (eye worm) TAR-binding protein 0.02 0.465 0.5935
Brugia malayi follicle stimulating hormone receptor 0.0239 0.5607 0.939
Echinococcus multilocularis Mastin 0.0019 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0375 0.0631
Schistosoma mansoni hypothetical protein 0.0067 0.142 0.142
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0212 0.2443
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0549 0.0549
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.142 0.142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0269 0.0343
Onchocerca volvulus 0.0019 0.0269 0.0202
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Brugia malayi Muscle positioning protein 4 0.004 0.0776 0.1299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0549 0.0701
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0019 0.0269 0.0269
Schistosoma mansoni hypothetical protein 0.004 0.0776 0.0776
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0549 0.0549
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0106 0.2362 0.2362
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0586 0.0586
Schistosoma mansoni notch 0.004 0.0776 0.0776
Brugia malayi Delta serrate ligand family protein 0.004 0.0776 0.1299
Echinococcus multilocularis muscleblind protein 0.0159 0.3666 0.3666
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0152 0.0152
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0106 0.2362 0.3955
Onchocerca volvulus 0.0067 0.1411 0.2172
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0023 0.0098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0149 0.1713
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2646 0.3378
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0106 0.2372 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.2113 0.8837
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.087 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0234 0.0384
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0211 0.4925 0.6286
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0152 0.0194
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0149 0.1713
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0212 0.2443
Trypanosoma brucei unspecified product 0.0015 0.0154 0.1775
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0149 0.0251
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Onchocerca volvulus Cell death protein 3 homolog 0.0067 0.1411 0.2172
Loa Loa (eye worm) RNA binding protein 0.02 0.465 0.5935
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0315 0.3623
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Echinococcus granulosus slit 2 protein 0.004 0.0776 0.0776
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0212 0.2443
Echinococcus multilocularis dnaJ subfamily B 0.0421 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0212 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.065 0.1093
Schistosoma mansoni hypothetical protein 0.0421 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0549 0.092
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0269 0.0269
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0152 0.0254
Schistosoma mansoni notch 0.004 0.0776 0.0776
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0157 0.02
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0416 0.3707
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.079 0.079
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0149 0.1713
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0549 0.0549
Echinococcus multilocularis fat cadherin tumor suppressor 0.004 0.0776 0.0776
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.087 0.3396
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0549 0.0686
Loa Loa (eye worm) histone methyltransferase 0.001 0.0047 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.087 0.1462
Brugia malayi Calcium binding EGF domain containing protein 0.004 0.0776 0.1299
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0812 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0019 0.0269 0.045
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0315 0.6218
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0315 0.0315
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0067 0.1411 0.1411
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0651 0.7487
Onchocerca volvulus 0.004 0.0776 0.1076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0269 0.0343
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0549 0.0701
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Loa Loa (eye worm) hypothetical protein 0.0159 0.3666 0.4679
Echinococcus multilocularis glycoprotein Antigen 5 0.0019 0.0269 0.0269
Echinococcus multilocularis protein jagged 1 0.004 0.0776 0.0776
Loa Loa (eye worm) glutathione reductase 0.0042 0.0812 0.1037
Schistosoma mansoni tar DNA-binding protein 0.02 0.465 0.465
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0019 0.0269 0.0269
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0651 0.6967
Schistosoma mansoni ran 0.0023 0.0351 0.0351
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.079 0.079
Echinococcus multilocularis neurogenic locus protein delta 0.004 0.0776 0.0776
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.142 0.142
Schistosoma mansoni notch 0.004 0.0776 0.0776
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0549 0.0549
Onchocerca volvulus 0.0033 0.0586 0.0749
Onchocerca volvulus 0.0019 0.0269 0.0202
Entamoeba histolytica hypothetical protein 0.0025 0.0408 0.1592
Schistosoma mansoni hypothetical protein 0.004 0.0776 0.0776
Schistosoma mansoni notch 0.004 0.0776 0.0776
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0067 0.1411 0.1801
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.079 0.079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0549 0.0549
Onchocerca volvulus Neurogenic locus notch protein homolog 0.004 0.0776 0.1076
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0157 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0154 0.1775
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0116 0.2602 0.3321
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0152 0.0152
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0351 0.2807
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0549 0.0549
Leishmania major DNA polymerase kappa, putative 0.0021 0.0315 0.2305
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0549 0.0549
Brugia malayi Cadherin domain containing protein 0.004 0.0776 0.1299
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Toxoplasma gondii calcium binding egf domain-containing protein 0.0106 0.2362 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0194 0.0248
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0194 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.065 0.1093
Brugia malayi Importin beta-1 subunit 0.0031 0.055 0.0921
Schistosoma mansoni hypothetical protein 0.0331 0.7835 0.7835
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0194 0.0194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0149 0.1713
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0549 0.092
Echinococcus multilocularis Tolloid protein 1 0.0106 0.2362 0.2362
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0549 0.092
Brugia malayi TAR-binding protein 0.02 0.465 0.7786
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0157 0.1803
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.087 1
Brugia malayi Trypsin family protein 0.0019 0.0269 0.045
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0416 1
Brugia malayi nuclear hormone receptor 0.0015 0.0152 0.0254
Leishmania major importin beta-1 subunit, putative 0.0025 0.0408 0.3589
Echinococcus granulosus importin subunit beta 1 0.0031 0.055 0.055
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.026 0.0498
Onchocerca volvulus 0.0052 0.1057 0.1561
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Brugia malayi hypothetical protein 0.0254 0.5972 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0549 0.0701
Brugia malayi nuclear receptor NHR-67 0.0015 0.0152 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0595 0.1
Schistosoma mansoni hypothetical protein 0.0067 0.142 0.142
Schistosoma mansoni egf-like domain protein 0.0106 0.2362 0.2362
Schistosoma mansoni cpg binding protein 0.0031 0.0554 0.0554
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.087 1
Brugia malayi ecdysone receptor 0.0015 0.0152 0.0254
Brugia malayi ecdysteroid receptor 0.0031 0.0549 0.092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0248
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Brugia malayi hypothetical protein 0.0015 0.0152 0.0254
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.079 0.1322
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0549 0.092
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.079 0.908
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0212 0.0212
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0004 0.0004
Trypanosoma brucei unspecified product 0.0015 0.0154 0.1775
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0432 0.0726
Echinococcus granulosus survival motor neuron protein 1 0.0254 0.5972 0.5972
Toxoplasma gondii thioredoxin reductase 0.0042 0.0812 0.344
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0595 0.1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0549 0.0549
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.055 0.6324
Brugia malayi steroid hormone receptor 0.0031 0.0549 0.092
Brugia malayi EGF-like domain containing protein 0.004 0.0776 0.1299
Giardia lamblia DINP protein human, muc B family 0.0021 0.0315 0.2305
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0549 0.0549
Schistosoma mansoni ran 0.0023 0.0351 0.0351
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0149 0.0249
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0315 0.0528
Schistosoma mansoni fkbp-rapamycin associated protein 0.0008 0.000000032381 0.000000032381
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0194 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0157 0.0264
Schistosoma mansoni hypothetical protein 0.004 0.0776 0.0776
Echinococcus multilocularis caspase 2 0.0067 0.1411 0.1411
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0152 0.0254
Entamoeba histolytica hypothetical protein 0.0114 0.2561 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0586 0.0586
Brugia malayi hypothetical protein 0.0114 0.2561 0.4288
Schistosoma mansoni cpg binding protein 0.003 0.0514 0.0514
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0152 0.0152
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0351 0.0351
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0416 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.214 0.214
Brugia malayi RNA recognition motif domain containing protein 0.02 0.465 0.7786
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0154 0.1775
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0106 0.2372 1
Schistosoma mansoni tar DNA-binding protein 0.02 0.465 0.465
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0549 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0493 0.083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0149 0.1713
Echinococcus granulosus neurogenic locus protein delta 0.004 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Schistosoma mansoni DNA polymerase eta 0.0021 0.0315 0.0315
Loa Loa (eye worm) DR-78 0.0015 0.0152 0.0194
Echinococcus granulosus apoptotic protease activating factor 1 0.0067 0.1411 0.1411
Schistosoma mansoni tar DNA-binding protein 0.02 0.465 0.465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0549 0.0549
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0149 0.0149
Schistosoma mansoni laminin gamma-3 chain 0.004 0.0776 0.0776
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1183 0.5008
Plasmodium vivax glutathione reductase, putative 0.0042 0.0812 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0152 0.0152
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.214 0.2732
Loa Loa (eye worm) hypothetical protein 0.0031 0.0549 0.0701
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0315 0.3623
Brugia malayi nuclear receptor NHR-88 0.0015 0.0152 0.0254
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.055 0.6324
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0351 0.3049
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0106 0.2362 0.3015
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.079 0.079
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0416 0.3707
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0826 0.0826
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.079 0.889
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Brugia malayi Muscleblind-like protein 0.0159 0.3666 0.6138
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Echinococcus multilocularis neural cadherin 0.004 0.0776 0.0776
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0315 0.1231
Plasmodium vivax SET domain protein, putative 0.0033 0.0586 0.6585
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0157 0.0263
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0408 0.4687
Brugia malayi Calcium binding EGF domain containing protein 0.004 0.0776 0.1299
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.214 0.214
Echinococcus multilocularis tar DNA binding protein 0.02 0.465 0.465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0375 0.0631
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0149 0.0251
Schistosoma mansoni hypothetical protein 0.004 0.0776 0.0776
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.5203 0.664
Echinococcus granulosus protein jagged 1 0.004 0.0776 0.0776
Echinococcus granulosus caspase 2 0.0067 0.1411 0.1411
Echinococcus multilocularis protein jagged 2 0.004 0.0776 0.0776
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0157 0.1803
Echinococcus granulosus muscleblind protein 0.0159 0.3666 0.3666
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.079 0.079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.142 0.142
Loa Loa (eye worm) hypothetical protein 0.0211 0.4925 0.6286
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0351 0.0351
Brugia malayi nuclear hormone receptor 0.0031 0.0549 0.092
Brugia malayi EGF-like domain containing protein 0.004 0.0776 0.1299
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.087 0.1456
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0416 0.0697
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0154 0.1775
Brugia malayi nuclear receptor NHR-88 0.0031 0.0549 0.092
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0149 0.0631
Echinococcus granulosus snurportin 1 0.0331 0.7835 0.7835
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0269 0.0269
Brugia malayi hypothetical protein 0.0019 0.0269 0.045
Schistosoma mansoni coup transcription factor 0.0031 0.0549 0.0549
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0586 0.0586
Schistosoma mansoni cpg binding protein 0.0031 0.0554 0.0554
Brugia malayi CXXC zinc finger family protein 0.003 0.0514 0.086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0549 0.092
Brugia malayi GCC2 and GCC3 family protein 0.004 0.0776 0.1299
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.087 0.111
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0408 0.0685
Loa Loa (eye worm) hypothetical protein 0.0031 0.0549 0.0701
Onchocerca volvulus 0.003 0.0514 0.0624
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0152 0.0152
Schistosoma mansoni tar DNA-binding protein 0.02 0.465 0.465
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0243 0.279
Entamoeba histolytica hypothetical protein 0.0114 0.2561 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.214 0.214
Brugia malayi Trypsin family protein 0.0019 0.0269 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0039
Schistosoma mansoni notch 0.004 0.0776 0.0776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0416 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0157 0.0264
Schistosoma mansoni zinc finger protein 0.0015 0.0152 0.0152
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0212 0.0212
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0549 0.092
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.087 0.3396
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0149 0.1713
Echinococcus granulosus dna polymerase eta 0.0021 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0713 0.1199
Schistosoma mansoni caspase-7 (C14 family) 0.0067 0.1411 0.1411
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.5607 0.7157
Echinococcus multilocularis cpg binding protein 0.0031 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0106 0.2362 0.3015
Schistosoma mansoni hypothetical protein 0.0067 0.142 0.142
Leishmania major DNA polymerase eta, putative 0.0021 0.0315 0.2305
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0416 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0416 0.0531
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0549 0.0549
Brugia malayi Trypsin-like protease protein 5 0.0019 0.0269 0.045
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.079 0.1328
Echinococcus granulosus enteropeptidase 0.0019 0.0269 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0586 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Schistosoma mansoni notch 0.004 0.0776 0.0776
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.004 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0438 0.0737
Echinococcus multilocularis fibrillin 1 0.0106 0.2362 0.2362
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0416 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Echinococcus granulosus GPCR family 2 0.0067 0.142 0.142
Plasmodium vivax importin-beta 2, putative 0.0031 0.055 0.6045
Brugia malayi Pre-SET motif family protein 0.0033 0.0586 0.0981
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0549 0.092
Brugia malayi MH2 domain containing protein 0.0117 0.2646 0.4432
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0157 0.0109
Giardia lamblia GTOR 0.0044 0.087 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0019 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Brugia malayi tailless protein 0.0015 0.0152 0.0254
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0542 0.0542
Echinococcus granulosus cpg binding protein 0.0031 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0019 0.0269 0.0343
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.004 0.0776 0.1299
Loa Loa (eye worm) hypothetical protein 0.0019 0.026 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0517 0.0869
Brugia malayi RNA, U transporter 1 0.0088 0.1938 0.3246
Echinococcus multilocularis snurportin 1 0.0331 0.7835 0.7835
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0152 0.0152
Schistosoma mansoni importin beta-1 0.0031 0.055 0.055
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0269 0.0269
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0152 0.0254
Loa Loa (eye worm) hypothetical protein 0.0031 0.055 0.0702
Loa Loa (eye worm) hypothetical protein 0.0031 0.0549 0.0701
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0315 0.0748
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0549 0.092
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0152 0.0152
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.079 0.908
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0351 0.3049
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0212 0.2443
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0056 0.0093
Schistosoma mansoni hypothetical protein 0.0144 0.3303 0.3303
Schistosoma mansoni hypothetical protein 0.0067 0.142 0.142
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.079 0.079
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.065 0.1093
Onchocerca volvulus 0.0019 0.0269 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0234 0.0384
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Schistosoma mansoni hypothetical protein 0.0114 0.2561 0.2561
Trypanosoma brucei unspecified product 0.0021 0.0315 0.3623
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0315 0.3623
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0106 0.2362 0.3015
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0549 0.0686
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.2113 0.8837
Echinococcus granulosus protein jagged 2 0.004 0.0776 0.0776
Brugia malayi Fibulin-1 precursor 0.0106 0.2362 0.3955
Echinococcus multilocularis notch 0.004 0.0776 0.0776
Brugia malayi hypothetical protein 0.0067 0.1411 0.2362
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0651 0.7487
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0432 0.0726
Schistosoma mansoni hypothetical protein 0.004 0.0776 0.0776
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0549 0.092
Trichomonas vaginalis ran, putative 0.0023 0.0351 0.0591
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0595 0.2519
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.079 0.079
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.465 0.5935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0157 0.0264
Echinococcus multilocularis transmembrane protease serine 3 0.0019 0.0269 0.0269
Onchocerca volvulus 0.004 0.0776 0.1076
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.3303 0.5531
Schistosoma mansoni hypothetical protein 0.0019 0.0269 0.0269
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.2561 0.2561
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0212 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.214 0.214
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Echinococcus multilocularis fibropellin Ia 0.004 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Toxoplasma gondii calcium binding egf domain-containing protein 0.0106 0.2362 1
Schistosoma mansoni nuclear receptor 0.0015 0.0152 0.0152
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.087 0.1462
Loa Loa (eye worm) hypothetical protein 0.004 0.0776 0.099
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0315 0.0402
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0416 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0595 0.1
Schistosoma mansoni septate junction protein 0.004 0.0776 0.0776
Echinococcus multilocularis laminin 0.0106 0.2362 0.2362
Echinococcus granulosus Mastin 0.0019 0.0269 0.0269
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0416 0.1625
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.2561 0.2561
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0549 0.0549
Echinococcus granulosus Tolloid protein 1 0.0106 0.2362 0.2362
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0212 0.0212
Brugia malayi Calcium binding EGF domain containing protein 0.0106 0.2362 0.3955
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0212 0.0212
Brugia malayi hypothetical protein 0.0015 0.0152 0.0254
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0194 0.0194
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0549 0.0549
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0041 0.079 0.1008
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0149 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.087 0.1462
Schistosoma mansoni hypothetical protein 0.0053 0.1072 0.1072
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0416 0.1202
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Onchocerca volvulus Putative cubilin 0.004 0.0776 0.1076
Onchocerca volvulus 0.004 0.0776 0.1076
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0812 0.1037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0315 0.0748
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0549 0.0549
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0351 0.4039
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0315 0.2305
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.026 0.4143
Brugia malayi Pre-SET motif family protein 0.0223 0.5203 0.8712
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1345 0.1345
Loa Loa (eye worm) hypothetical protein 0.0106 0.2362 0.3015
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.055 0.2329
Echinococcus granulosus neurogenic locus notch protein 0.004 0.0776 0.0776
Echinococcus multilocularis enteropeptidase 0.0019 0.0269 0.0269
Brugia malayi Thioredoxin reductase 0.0042 0.0812 0.1361
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0106 0.2362 0.3015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0416 0.0531
Echinococcus multilocularis transcription factor eb 0.0116 0.2616 0.2616
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.2113 0.8837
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.079 0.889
Echinococcus multilocularis neurogenic locus notch protein 0.004 0.0776 0.0776
Onchocerca volvulus Arrow homolog 0.0106 0.2362 0.3813
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0315 0.3623
Echinococcus granulosus notch 0.004 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0067 0.142 0.1812
Echinococcus multilocularis muscleblind protein 1 0.0159 0.3666 0.3666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.065 0.1093
Onchocerca volvulus 0.0019 0.0269 0.0202
Loa Loa (eye worm) hypothetical protein 0.0026 0.0416 0.0531
Loa Loa (eye worm) hypothetical protein 0.0254 0.5972 0.7622
Mycobacterium ulcerans hypothetical protein 0.0026 0.0416 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0149 0.5
Onchocerca volvulus 0.0253 0.5947 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.214 0.3584
Loa Loa (eye worm) hypothetical protein 0.0106 0.2362 0.3015
Schistosoma mansoni hypothetical protein 0.004 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0019 0.0269 0.0343
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0116 0.2616 0.438
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0194
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0549 0.0549
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0152 0.0152
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0351 0.1487
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0157 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0315 0.3623
Schistosoma mansoni survival motor neuron protein 0.0052 0.1057 0.1057
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0194 0.0326
Loa Loa (eye worm) hypothetical protein 0.0106 0.2362 0.3015
Echinococcus granulosus delta-like protein 1 0.004 0.0776 0.0776
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0106 0.2372 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0549 0.0701
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0149 0.1713
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0586 0.0586
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.004 0.0776 0.0776
Echinococcus granulosus laminin 0.0106 0.2362 0.2362
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2372 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.026 0.0331
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0149 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Leishmania major trypanothione reductase 0.0042 0.0812 0.9206
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.003
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.087 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0595 0.1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0157 0.0109
Schistosoma mansoni cell polarity protein 0.004 0.0776 0.0776
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0211 0.4925 0.8248
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0416 0.1625
Loa Loa (eye worm) notch protein 0.004 0.0776 0.099
Schistosoma mansoni slit 0.004 0.0776 0.0776
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.2561 0.2561
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0549 0.092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0269 0.0343
Leishmania major GTP-binding protein, putative 0.0023 0.0351 0.2807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0376 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0376 0.0633
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.142 0.1812
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0157 0.1803
Loa Loa (eye worm) Notch2 0.004 0.0776 0.099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0269 0.0343
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.026 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0549 0.092
Mycobacterium tuberculosis Probable reductase 0.0095 0.2113 0.8837
Entamoeba histolytica hypothetical protein 0.0114 0.2561 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.087 0.087
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.079 0.3084
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0149 0.1713
Mycobacterium ulcerans hypothetical protein 0.0019 0.0269 0.4492
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Onchocerca volvulus 0.0019 0.0269 0.0202
Brugia malayi hypothetical protein 0.0016 0.0194 0.0326
Echinococcus granulosus fibropellin Ia 0.004 0.0776 0.0776
Brugia malayi EGF-like domain containing protein 0.004 0.0776 0.1299
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0248
Echinococcus granulosus tar DNA binding protein 0.02 0.465 0.465
Onchocerca volvulus 0.0019 0.0269 0.0202
Schistosoma mansoni hypothetical protein 0.0019 0.0269 0.0269
Entamoeba histolytica hypothetical protein 0.0114 0.2561 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0315 0.053
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0269 0.0269
Echinococcus multilocularis survival motor neuron protein 1 0.0254 0.5972 0.5972
Echinococcus multilocularis neurogenic locus notch protein 4 0.004 0.0776 0.0776
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0549 0.0549
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0595 0.1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.2113 0.8837
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.087 1
Brugia malayi EGF-like domain containing protein 0.004 0.0776 0.1299

Activities

Activity type Activity value Assay description Source Reference
Reduction (functional) = 18 % Percent reduction in spleen weight in mice as compared to infected untreated controls at 100 mg/kg ChEMBL. 6644739

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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