TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 416.921 | Formula: C21H21ClN2O3S
H donors: 1 H acceptors: 2 LogP: 4.46 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)Cc1scc(n1)c1ccc2c(c1)CCC(=O)N2.Cl
InChi: 1S/C21H20N2O3S.ClH/c1-25-18-7-3-13(9-19(18)26-2)10-21-23-17(12-27-21)15-4-6-16-14(11-15)5-8-20(24)22-16;/h3-4,6-7,9,11-12H,5,8,10H2,1-2H3,(H,22,24);1H
InChiKey: XFBGRNZFYHDDDO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0273	0.0377	0.037
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0027	0.002	0.0012
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.0009	0.0002
Schistosoma mansoni	sodium/chloride dependent transporter	0.0159	0.0211	0.0204
Brugia malayi	hypothetical protein	0.0261	0.0359	0.0359
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0009	0.0002
Leishmania major	trypanothione reductase	0.0053	0.0057	0.0059
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.5868	0.8495	0.8495
Brugia malayi	Thioredoxin reductase	0.0053	0.0057	0.0057
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.0009	0.0002
Brugia malayi	Melatonin receptor type 1A	0.0019	0.0009	0.0009
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	synaptic vesicular amine transporter	0.0192	0.0259	0.0252
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0007	0.0006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.0009	0.0002
Brugia malayi	follicle stimulating hormone receptor	0.0273	0.0377	0.0377
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0018	0.0007	0.0666
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0009	0.0002
Plasmodium vivax	glutathione reductase, putative	0.0053	0.0057	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.0009	0.0002
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.0009	0.0002
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0011	0.0011
Loa Loa (eye worm)	alpha-L-fucosidase	0.0251	0.0345	0.0337
Schistosoma mansoni	amine GPCR	0.0019	0.0009	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0009	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0009	0.0002
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.0009	0.0009
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0027	0.002	0.0012
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0222	0.5996
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0011	0.0011
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0159	0.0211	0.0204
Loa Loa (eye worm)	hypothetical protein	0.2999	0.4332	0.4328
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0222	0.5996
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0009	0.0002
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.0349	0.9528
Brugia malayi	RE15519p	0.0019	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0009	0.0002
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0011	0.0117
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.5868	0.8495	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0011	0.0004
Echinococcus granulosus	allatostatin A receptor	0.0019	0.0009	0.0002
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0011	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0009	0.0002
Leishmania major	C-8 sterol isomerase-like protein	0.5868	0.8495	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.0009	0.0002
Echinococcus granulosus	serotonin receptor	0.0019	0.0009	0.0002
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.0349	0.9528
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.0009	0.0001
Toxoplasma gondii	exonuclease III APE	0.0021	0.0011	0.1344
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0027	0.002	0.3011
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Brugia malayi	G-protein coupled receptor	0.0019	0.0009	0.0009
Brugia malayi	putative neuropeptide receptor	0.0019	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0009	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0009	0.0002
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0011	0.0003
Onchocerca volvulus		0.0034	0.0029	0.002
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0027	0.002	0.002
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Brugia malayi	larval opioid receptor	0.0019	0.0009	0.0009
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	amine GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	vesicular acetylcholine transporter	0.6906	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0011	0.0005
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0135	0.0176	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0029	0.0022
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.0009	0.0009
Brugia malayi	sulfakinin receptor protein	0.0019	0.0009	0.0009
Plasmodium falciparum	amino acid transporter, putative	0.0027	0.002	0.2474
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.011	0.014	0.3704
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0011	0.0003
Brugia malayi	neuropeptide F receptor	0.0019	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Mycobacterium ulcerans	alpha-L-fucosidase	0.0415	0.0583	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.0009	0.0001
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0009	0.0002
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0041	0.6877
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.0009	0.0002
Onchocerca volvulus		0.0027	0.002	0.0011
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0027	0.002	0.3011
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0027	0.002	0.0012
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Echinococcus granulosus	beta galactosidase	0.0136	0.0177	0.017
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0121	0.0156	0.8837
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0011	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0015	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0011	0.0005
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0011	0.0004
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	sex peptide receptor	0.0019	0.0009	0.0002
Brugia malayi	GnHR receptor homolog	0.0019	0.0009	0.0009
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0011	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0011	0.0004
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0011	0.0095
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0011	0.0203
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0254	0.0349	0.0342
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.0009	0.0001
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0015	0.0208
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.0057	0.2985
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0027	0.002	0.002
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0027	0.002	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.0057	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.0009	0.0002
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0009	0.0002
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0041	0.0041	0.6654
Schistosoma mansoni	opsin-like receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.0009	0.0002
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0011	0.0004
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0009	0.0002
Trypanosoma brucei	trypanothione reductase	0.0053	0.0057	0.0066
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0027	0.002	0.0012
Onchocerca volvulus		0.0027	0.002	0.0011
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.0009	0.0009
Leishmania major	C-14 sterol reductase, putative	0.0092	0.0113	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.0009	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Brugia malayi	Serotonin receptor	0.0019	0.0009	0.0009
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.0009	0.0002
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0009	0.0002
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0029	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0048	0.005	0.005
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	sex peptide receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.0009	0.0002
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.0349	0.9528
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0027	0.002	0.0012
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0018	0.0007	0.0666
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0027	0.002	0.002
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0009	0.0002
Mycobacterium tuberculosis	Probable dehydrogenase	0.0121	0.0156	0.8837
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0011	0.0679
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0011	0.0249
Echinococcus multilocularis	beta galactosidase	0.0136	0.0177	0.017
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Schistosoma mansoni	amine GPCR	0.0019	0.0009	0.0002
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0011	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0222	0.5996
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0012
Onchocerca volvulus	Glucosylceramidase homolog	0.0167	0.0222	0.0214
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	opsin-like receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0009	0.0001
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0009	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0261	0.0359	0.0352
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0011	0.0059
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.0009	0.0002
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0012
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.5868	0.8495	0.8494
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0009	0.0001
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0009	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0011	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0211	0.0204
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0007	0.0006
Leishmania major	DNA polymerase eta, putative	0.0021	0.0011	0.0005
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0058	0.0058
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0177	0.017
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0027	0.002	0.0012
Trypanosoma brucei	C-8 sterol isomerase, putative	0.5868	0.8495	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0011	0.0117
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.0415	0.0583	0.0576
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.0057	0.005
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.0349	0.9528
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0029	0.4761
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0027	0.002	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.0009	0.0002
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0011	0.001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0027	0.002	0.0012
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0058	0.0051
Schistosoma mansoni	hypothetical protein	0.0377	0.0528	0.0521
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0121	0.0156	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0011	0.0095
Echinococcus multilocularis	synaptic vesicular amine transporter	0.0192	0.0259	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0222	0.5996
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0009	0.0002
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0254	0.0349	0.0349
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0027	0.002	0.0012
Echinococcus granulosus	serotonin transporter	0.0159	0.0211	0.0204
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	hypothetical protein	0.0019	0.0009	0.0002
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0027	0.002	0.0012
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.0009	0.0002
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0011	0.0011
Echinococcus granulosus	vesicular acetylcholine transporter	0.6906	1	1
Brugia malayi	Dopamine receptor protein 1	0.0019	0.0009	0.0009
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0092	0.0113	0.0125
Brugia malayi	Dopamine receptor	0.0019	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Brugia malayi	glutathione reductase	0.0053	0.0057	0.0057
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0018	0.0007	0.0007
Loa Loa (eye worm)	abnormal catecholamine distribution protein 1	0.0192	0.0259	0.0252
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0011	0.0005
Echinococcus granulosus	tm gpcr rhodopsin	0.111	0.1592	0.1586
Brugia malayi	G-protein coupled receptor	0.0019	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0029	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Schistosoma mansoni	myosin xvIII	0.0019	0.0009	0.0002
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	lamin b receptor	0.0092	0.0113	0.0106
Echinococcus granulosus	dna polymerase eta	0.0021	0.0011	0.0004
Brugia malayi	hypothetical protein	0.0027	0.002	0.002
Echinococcus multilocularis	geminin	0.0377	0.0528	0.0521
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0011	0.0005
Echinococcus granulosus	geminin	0.0377	0.0528	0.0521
Brugia malayi	Serotonin receptor	0.0019	0.0009	0.0009
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	sodium/chloride dependent transporter	0.0027	0.002	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0012
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.0009	0.0009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0015	0.0015
Brugia malayi	Pre-SET motif family protein	0.0234	0.0319	0.0319
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0159	0.0211	0.0204
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.002	0.2976
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0234	0.0319	0.0312
Onchocerca volvulus		0.0027	0.002	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Brugia malayi	G protein-coupled receptor	0.0019	0.0009	0.0009
Loa Loa (eye worm)	serotonin transporter b	0.0159	0.0211	0.0204
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0027	0.002	0.0012
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0011	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0029	0.0022
Schistosoma mansoni	sodium/chloride dependent transporter	0.0027	0.002	0.0012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0009	0.0002
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0011	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	sodium and chloride dependent glycine	0.0027	0.002	0.0012
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0011	0.0004
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0222	0.5996
Brugia malayi	Pre-SET motif family protein	0.0034	0.0029	0.0029
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0009	0.0002
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.011	0.014	0.3704
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0009	0.0002
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	hypothetical protein	0.0053	0.0058	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0222	0.5996
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.0009	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0009	0.0002
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	sodium and chloride dependent glycine	0.0027	0.002	0.0012
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0135	0.0176	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.0009	0.0009
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0027	0.002	0.0012
Echinococcus multilocularis	serotonin receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0009	0.0001
Brugia malayi	Alpha-L-fucosidase family protein	0.0251	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0211	0.0204
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0018	0.0007	0.0714
Leishmania major	sterol C-24 reductase, putative	0.0048	0.005	0.005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0009	0.0002
Schistosoma mansoni	hypothetical protein	0.0019	0.0009	0.0002
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.0349	0.9528
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Schistosoma mansoni	Lamin B receptor (ERG24)	0.0092	0.0113	0.0106
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0029	0.0022
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0236	0.6359
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0011	0.0004
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0011	0.13
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	somatostatin receptor	0.0019	0.0009	0.0002
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0011	0.0011
Echinococcus multilocularis	somatostatin receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0027	0.002	0.0012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.6906	1	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0261	0.0359	0.0352
Schistosoma mansoni	hypothetical protein	0.0019	0.0009	0.0002
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.0057	0.005
Schistosoma mansoni	alpha-l-fucosidase	0.0251	0.0345	0.0338
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.111	0.1592	0.1586
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0029	0.0022
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0018	0.0007	0.0006
Toxoplasma gondii	hypothetical protein	0.0027	0.002	0.3011
Schistosoma mansoni	ap endonuclease	0.0021	0.0011	0.0003
Schistosoma mansoni	adenoreceptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Trichomonas vaginalis	set domain proteins, putative	0.0266	0.0366	1
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0092	0.0113	0.0125
Trypanosoma brucei	unspecified product	0.0021	0.0011	0.0011
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0159	0.0211	0.0211
Echinococcus granulosus	orexin receptor type 2	0.0019	0.0009	0.0002
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.0009	0.0002
Toxoplasma gondii	NADPH-glutathione reductase	0.0018	0.0007	0.0714
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.0009	0.0002
Plasmodium vivax	amine transporter, putative	0.0027	0.002	0.2976
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0011	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0027	0.002	0.0012
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.0415	0.0583	0.0576
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0011	0.8127
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0011	0.0004
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0011	0.0011
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0011	0.0004
Mycobacterium tuberculosis	Probable oxidoreductase	0.0135	0.0176	1
Trypanosoma brucei	C-14 sterol reductase, putative	0.0092	0.0113	0.0132
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0222	0.5996
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0029	0.0022
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0015	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Schistosoma mansoni	ap endonuclease	0.0021	0.0011	0.0003
Treponema pallidum	sodium- and chloride- dependent transporter	0.0159	0.0211	1
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.0009	0.0009
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0048	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0009	0.0002
Brugia malayi	Dopamine receptor protein 2	0.0019	0.0009	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Toxoplasma gondii	hypothetical protein	0.0027	0.002	0.3011
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0135	0.0176	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0018	0.0007	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0177	0.017
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0027	0.002
Echinococcus multilocularis	serotonin transporter	0.0159	0.0211	0.0204
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0011	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0027	0.002	0.3011
Plasmodium falciparum	thioredoxin reductase	0.0053	0.0057	1
Schistosoma mansoni	hypothetical protein	0.0377	0.0528	0.0521
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0027	0.002	0.0012
Echinococcus multilocularis	serotonin receptor	0.0019	0.0009	0.0002
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0011	1
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0048	0.005	0.0042
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0012
Schistosoma mansoni	vesicular amine transporter	0.0192	0.0259	0.0252
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Toxoplasma gondii	thioredoxin reductase	0.0053	0.0057	1
Loa Loa (eye worm)	norepinephrine transporter	0.0159	0.0211	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.0057	0.0059
Mycobacterium tuberculosis	Probable reductase	0.0121	0.0156	0.8837
Plasmodium falciparum	transporter, putative	0.0027	0.002	0.2474
Onchocerca volvulus		0.0053	0.0058	0.0049
Schistosoma mansoni	amine GPCR	0.0019	0.0009	0.0002
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0027	0.002	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Plasmodium falciparum	glutathione reductase	0.0053	0.0057	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0211	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0027	0.002	0.0012
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.0349	0.9528
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.0057	0.005
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0027	0.002	0.002
Echinococcus granulosus	fmrfamide receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.0009	0.0002
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0011	0.0003
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.0009	0.0002
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.6906	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0009	0.0002
Brugia malayi	AKH receptor	0.0019	0.0009	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0011	0.0249
Schistosoma mansoni	histamine h1 receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.0009	0.0002
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.0009	0.0002
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0011	0.0011
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0027	0.002	1
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0011	0.0005
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0009	0.0002
Plasmodium vivax	SET domain protein, putative	0.0034	0.0029	0.4734
Schistosoma mansoni	hypothetical protein	0.0019	0.0009	0.0002
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.0009	0.0002
Schistosoma mansoni	amine GPCR	0.0019	0.0009	0.0002
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.0009	0.0002
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0121	0.0156	0.8837
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.0009	0.0001
Brugia malayi	ORL1-like opioid receptor	0.0019	0.0009	0.0009
Schistosoma mansoni	beta-galactosidase	0.0136	0.0177	0.017
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.0009	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Echinococcus granulosus	lamin b receptor	0.0092	0.0113	0.0106
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0011	0.0004
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0121	0.0156	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0009	0.0002
Schistosoma mansoni	opsin-like receptor	0.0019	0.0009	0.0002
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0027	0.002	0.0012
Brugia malayi	Abnormal catecholamine distribution protein 1	0.0192	0.0259	0.0259
Onchocerca volvulus		0.0266	0.0366	0.0358
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0009	0.0002
Loa Loa (eye worm)	glutathione reductase	0.0053	0.0057	0.005
Brugia malayi	hypothetical protein	0.0019	0.0009	0.0009
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.0009	0.0001
Echinococcus granulosus	survival motor neuron protein 1	0.0261	0.0359	0.0352
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0015	0.0007
Brugia malayi	neuropeptide F receptor	0.0019	0.0009	0.0009
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0009	0.0002
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0015	0.0007
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0011	0.0005
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.001	0.066
Schistosoma mansoni	vesicular acetylcholine transporter	0.6906	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Echinococcus granulosus	hypothetical protein	0.0019	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0001
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.0009	0.0009
Onchocerca volvulus		0.0159	0.0211	0.0203
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0009	0.0002
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0236	0.6359
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0027	0.002	0.0012
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0011	0.0011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0009	0.0002
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.0009	0.0002
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0011	0.0005

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 10 uM	In vitro inhibitory activity against superoxide production from human neutrophils stimulated with f-MLP	ChEMBL.	7830278

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	7830278

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL543645

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1033095