Detailed information for compound 1033976

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 789.554 | Formula: C48H74ClN4OP
  • H donors: 3 H acceptors: 1 LogP: 12.92 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)N/C(=N/C1CCCCC1)/NC1CCCCC1)(CCCCC)CCCCC.[Cl-]
  • InChi: 1S/C48H73N4OP.ClH/c1-4-7-18-33-54(34-19-8-5-2,35-20-9-6-3)38-39-28-31-45(32-29-39)49-47(53)46(37-40-27-30-41-21-16-17-22-42(41)36-40)52-48(50-43-23-12-10-13-24-43)51-44-25-14-11-15-26-44;/h16-17,21-22,27-32,36,43-44,46H,4-15,18-20,23-26,33-35,37-38H2,1-3H3,(H2-,49,50,51,52,53);1H/t46-;/m0./s1
  • InChiKey: JGPDCPRNFNAICG-IDCINFOJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bradykinin receptor B2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor bradykinin receptor B2 391 aa 354 aa 19.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Brugia malayi neuropeptide F receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.006 0.006
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0007 0.0007
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.0716 1
Trichomonas vaginalis set domain proteins, putative 0.049 0.1229 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0129 0.0129
Loa Loa (eye worm) glutathione reductase 0.01 0.0227 0.0227
Echinococcus multilocularis sex peptide receptor 0.0015 0.0007 0.0007
Echinococcus granulosus synaptic vesicular amine transporter 0.0187 0.0451 0.045
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0159 0.1347
Loa Loa (eye worm) hypothetical protein 0.005 0.0097 0.0097
Onchocerca volvulus 0.0025 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0143 0.0338 0.2867
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0159 0.129
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.0556 0.8586
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0147 0.0346 0.0346
Onchocerca volvulus 0.0015 0.0007 0.0007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi hypothetical protein 0.0075 0.0162 0.0162
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0022 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0147 0.0346 0.0346
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0076 0.0614
Brugia malayi PHD-finger family protein 0.0029 0.0044 0.0044
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0044 0.0044
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0073 0.0073
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Schistosoma mansoni biogenic amine receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0159 0.1347
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.1474
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0034
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0157 0.0374 0.0374
Schistosoma mansoni survival motor neuron protein 0.0051 0.0101 0.0101
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0044 0.0044
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0059 0.0583
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0015 0.0007 0.0007
Schistosoma mansoni glycogen phosphorylase 0.0331 0.0821 0.0821
Onchocerca volvulus 0.0015 0.0007 0.0007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0159 0.217
Loa Loa (eye worm) TYRA-2 protein 0.0015 0.0007 0.0007
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Onchocerca volvulus Glycogen phosphorylase homolog 0.0331 0.0821 0.0821
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0034 0.0033
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0121 0.1469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Loa Loa (eye worm) hypothetical protein 0.025 0.0611 0.0611
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0059 0.2586
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0074
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.3906 1 1
Onchocerca volvulus 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0121 0.0153
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0044 0.194
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0121 0.1024
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0159 0.0159
Echinococcus granulosus dna polymerase eta 0.002 0.0022 0.0022
Onchocerca volvulus 0.0015 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0007 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0162 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Loa Loa (eye worm) glutaminase 0.0266 0.0652 0.0652
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0227 0.0227
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0123 0.0122
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Trichomonas vaginalis esterase, putative 0.0074 0.0159 0.129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0129 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0007 0.0007
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0227 0.1925
Brugia malayi G-protein coupled receptor 0.0015 0.0007 0.0007
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0227 1
Brugia malayi beta-lactamase 0.0074 0.0159 0.0159
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0015 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Echinococcus multilocularis synaptic vesicular amine transporter 0.0187 0.0451 0.045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0159 0.6997
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Brugia malayi AKH receptor 0.0015 0.0007 0.0007
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0034 0.0034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0121 0.0153
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0147 0.0346 0.0346
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0022 0.0028
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0001 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0007 0.0007
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus dna polymerase kappa 0.002 0.0022 0.0022
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0022 0.0178
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Brugia malayi RE15519p 0.0015 0.0007 0.0007
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.0611 0.0611
Brugia malayi carbohydrate phosphorylase 0.0331 0.0821 0.0821
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni vesicular acetylcholine transporter 0.3906 1 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0009 0.0382
Brugia malayi Serotonin receptor 0.0015 0.0007 0.0007
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0028 0.0028
Mycobacterium tuberculosis Conserved protein 0.0074 0.0159 0.1347
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0034 0.0033
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0034 0.0034
Mycobacterium tuberculosis Probable oxidoreductase 0.0254 0.0622 0.5278
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0001 0.0004
Plasmodium vivax SET domain protein, putative 0.0062 0.0129 0.5658
Brugia malayi Serotonin receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0034 0.0033
Echinococcus multilocularis Glycosyl transferase, family 35 0.0331 0.0821 0.0821
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Brugia malayi Pre-SET motif family protein 0.0062 0.0129 0.0129
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0345 0.0345
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0159 0.129
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0007 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0129 0.5658
Brugia malayi jmjC domain containing protein 0.0095 0.0214 0.0214
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0121 0.0153
Echinococcus granulosus geminin 0.0525 0.1319 0.1319
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0007 0.0007
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0034 0.0033
Trypanosoma brucei unspecified product 0.0014 0.0006 0.0007
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.033 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Brugia malayi Cytochrome P450 family protein 0.003 0.0046 0.0046
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0051 0.0101 0.01
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0159 0.0159
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0334 0.3794
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0015 0.0007 0.0007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.033 0.033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0034 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Onchocerca volvulus 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0075 0.0162 0.1973
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0159 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus multilocularis neuropeptide FF receptor 2 0.0015 0.0007 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0067 0.0812
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0059 0.0498
Brugia malayi GnHR receptor homolog 0.0015 0.0007 0.0007
Plasmodium falciparum thioredoxin reductase 0.0035 0.0059 0.2586
Mycobacterium tuberculosis Probable reductase 0.0228 0.0556 0.4722
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0067 0.294
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0159 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0159 0.0159
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0021 0.0899
Schistosoma mansoni opsin-like receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0007 0.0007
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.1474
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0034 0.0034
Loa Loa (eye worm) RecQ helicase 0.0023 0.0028 0.0027
Echinococcus granulosus G protein coupled receptor 139 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0159 0.1347
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.0716 0.8723
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0074
Schistosoma mansoni hypothetical protein 0.0525 0.1319 0.1319
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0121 0.1684
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus g protein coupled receptor 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0074 0.0159 0.0159
Loa Loa (eye worm) beta-lactamase 0.0074 0.0159 0.0159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0345 0.0345
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0007 0.0007
Echinococcus granulosus survival motor neuron protein 1 0.025 0.0611 0.0611
Mycobacterium ulcerans hypothetical protein 0.0074 0.0159 0.217
Brugia malayi hypothetical protein 0.0157 0.0374 0.0374
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0345 0.0345
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.1178 1
Schistosoma mansoni histamine h1 receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0007 0.0007
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0007 0.0007
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Echinococcus multilocularis dna polymerase eta 0.002 0.0022 0.0022
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Toxoplasma gondii thioredoxin reductase 0.01 0.0227 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0143 0.0338 0.5012
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0059 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0076 0.333
Onchocerca volvulus 0.0015 0.0007 0.0007
Plasmodium falciparum thioredoxin reductase 0.01 0.0227 1
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0015 0.0007 0.0007
Echinococcus granulosus tachykinin peptides receptor 99D 0.0015 0.0007 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0059 0.2586
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0059 0.2586
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0007 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0716 0.8723
Onchocerca volvulus 0.0015 0.0007 0.0007
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0034 0.0033
Echinococcus multilocularis serotonin transporter 0.0147 0.0346 0.0346
Brugia malayi neuropeptide F receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis vesicular acetylcholine transporter 0.3906 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0121 0.0981
Entamoeba histolytica glycogen phosphorylase, putative 0.0331 0.0821 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0254 0.0622 0.5278
Schistosoma mansoni hypothetical protein 0.0029 0.0044 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0162 0.0162
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0015 0.0007 0.0007
Giardia lamblia PHD finger protein 15 0.0029 0.0044 0.0536
Brugia malayi Pre-SET motif family protein 0.0431 0.1076 0.1076
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0076 0.0614
Echinococcus granulosus glycogen phosphorylase 0.0331 0.0821 0.0821
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0345 0.0345
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.006 0.006
Brugia malayi G-protein coupled receptor 0.0015 0.0007 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0007 0.0007
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0044 0.0044
Echinococcus multilocularis allatostatin A receptor 0.0015 0.0007 0.0007
Plasmodium falciparum phd finger protein, putative 0.0029 0.0044 0.194
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0007 0.0007
Brugia malayi putative neuropeptide receptor 0.0015 0.0007 0.0007
Echinococcus granulosus dro:myosuppressin receptor 0.0015 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0033
Trypanosoma brucei C-8 sterol isomerase, putative 0.3074 0.7865 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0015 0.0007 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0345 0.0345
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0059 0.0074
Schistosoma mansoni alpha-1 adrenergic receptor 0.0015 0.0007 0.0007
Brugia malayi glutaminase DH11.1 0.0266 0.0652 0.0652
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0076 0.333
Schistosoma mansoni glutaminase 0.0266 0.0652 0.0652
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0046 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0583
Brugia malayi Bromodomain containing protein 0.0032 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0059
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0044 0.194
Schistosoma mansoni biogenic amine receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0121 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus neuropeptide receptor 0.0015 0.0007 0.0007
Trypanosoma brucei unspecified product 0.0014 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0059 0.0714
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0015 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0007 0.0007
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0016 0.0016
Loa Loa (eye worm) melatonin receptor type 1A 0.0015 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0159 0.129
Echinococcus granulosus hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0159 0.129
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Loa Loa (eye worm) hypothetical protein 0.0147 0.0346 0.0346
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0059 0.2586
Schistosoma mansoni neuropeptide receptor 0.0015 0.0007 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0227 0.0288
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0121 0.0981
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0007 0.0007
Echinococcus granulosus alpha 1A adrenergic receptor 0.0015 0.0007 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.1474
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi Abnormal catecholamine distribution protein 1 0.0187 0.0451 0.0451
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0007 0.0007
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0034 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0159 0.0202
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0034 0.0033
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.032 0.032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis geminin 0.0525 0.1319 0.1319
Schistosoma mansoni neuropeptide receptor 0.0015 0.0007 0.0007
Echinococcus granulosus glycogen phosphorylase 0.0331 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Schistosoma mansoni biogenic amine receptor 0.0015 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Schistosoma mansoni ap endonuclease 0.0059 0.0121 0.0121
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0121 0.5321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus orexin receptor type 2 0.0015 0.0007 0.0007
Echinococcus granulosus allatostatin A receptor 0.0015 0.0007 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0101 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0007 0.0007
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0334 0.4958
Onchocerca volvulus 0.0015 0.0007 0.0007
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0059
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0254 0.0622 0.5278
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0034 0.0034
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0067 0.0812
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus neuropeptide receptor A26 0.0015 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0159 0.0202
Leishmania major trypanothione reductase 0.01 0.0227 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni sodium/chloride dependent transporter 0.0147 0.0346 0.0346
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0022
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0121 0.5321
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0214 0.0213
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0334 0.2838
Mycobacterium tuberculosis Conserved protein 0.0074 0.0159 0.1347
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.0556 0.4722
Echinococcus granulosus serotonin receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.0556 0.4722
Schistosoma mansoni neuropeptide receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Schistosoma mansoni growth hormone secretagogue receptor 0.0015 0.0007 0.0007
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0157 0.0374 0.0374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0716 0.8723
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0059 0.0074
Loa Loa (eye worm) acetyltransferase 0.014 0.033 0.033
Echinococcus granulosus serotonin transporter 0.0147 0.0346 0.0346
Trichomonas vaginalis glycogen phosphorylase, putative 0.0331 0.0821 0.6679
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0159 0.1347
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0022 0.0028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0254 0.0622 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.0338 0.4113
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0059 0.0477
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0028
Echinococcus granulosus bloom syndrome protein 0.0023 0.0028 0.0027
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0015 0.0007 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0121 0.0121
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0034 0.0033
Brugia malayi Thioredoxin reductase 0.01 0.0227 0.0227
Plasmodium vivax glutathione reductase, putative 0.01 0.0227 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0028 0.0223
Echinococcus granulosus jumonji domain containing protein 0.004 0.0073 0.0073
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0059 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Brugia malayi Dopamine receptor protein 1 0.0015 0.0007 0.0007
Brugia malayi G protein-coupled receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.3906 1 1
Mycobacterium ulcerans lipase LipD 0.0074 0.0159 0.217
Echinococcus multilocularis somatostatin receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0007 0.0007
Schistosoma mansoni myosin xvIII 0.0015 0.0007 0.0007
Loa Loa (eye worm) solute carrier family 6 member 4 0.0147 0.0346 0.0346
Plasmodium falciparum glutathione reductase 0.0035 0.0059 0.2586
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0007 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0044 0.194
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.0556 0.4722
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0022 0.0266
Schistosoma mansoni opsin-like receptor 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Brugia malayi Melatonin receptor type 1A 0.0015 0.0007 0.0007
Entamoeba histolytica glycogenphosphorylase, putative 0.0143 0.0338 0.4113
Onchocerca volvulus 0.0074 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0044
Onchocerca volvulus 0.0074 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis orexin receptor type 2 0.0015 0.0007 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0051 0.0101 0.0101
Toxoplasma gondii ABC1 family protein 0.0074 0.0159 0.6997
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0075 0.0162 0.0162
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0525 0.1319 0.1319
Onchocerca volvulus 0.049 0.1229 0.1229
Onchocerca volvulus 0.0062 0.0129 0.0128
Loa Loa (eye worm) norepinephrine transporter 0.0147 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0028 0.0027
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0022 0.0178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Plasmodium falciparum amino acid transporter, putative 0.0025 0.0034 0.1474
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0159 0.1347
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0059 0.2586
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0258 0.0632 0.0631
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0159 0.0159
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.006 0.006
Toxoplasma gondii hypothetical protein 0.0025 0.0034 0.1474
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0162 0.0162
Echinococcus multilocularis g-protein coupled receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) serotonin transporter b 0.0147 0.0346 0.0346
Echinococcus multilocularis neuropeptide s receptor 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0074 0.0159 0.0202
Brugia malayi follicle stimulating hormone receptor 0.0258 0.0632 0.0632
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0034 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.006 0.006
Echinococcus granulosus sex peptide receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.0186
Echinococcus granulosus peregrin 0.0032 0.0053 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0345 0.0345
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0059 0.032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0035 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Brugia malayi glutathione reductase 0.01 0.0227 0.0227
Giardia lamblia Glycogen phosphorylase 0.0331 0.0821 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0007 0.0007
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Echinococcus multilocularis peregrin 0.0032 0.0053 0.0053
Chlamydia trachomatis glycogen phosphorylase 0.0331 0.0821 1
Schistosoma mansoni adenoreceptor 0.0015 0.0007 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0059 0.2586
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0007 0.0007
Echinococcus granulosus neuropeptide FF receptor 2 0.0015 0.0007 0.0007
Echinococcus multilocularis G protein coupled receptor 139 0.0015 0.0007 0.0007
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Treponema pallidum sodium- and chloride- dependent transporter 0.0147 0.0346 0.4832
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0074 0.0159 0.1347
Trypanosoma brucei trypanothione reductase 0.01 0.0227 0.0288
Echinococcus granulosus g protein coupled receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.056 0.1408 0.1408
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0028
Echinococcus granulosus Glycosyl transferase family 35 0.0331 0.0821 0.0821
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0187 0.0451 0.045
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0007 0.0007
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0129 0.0128
Onchocerca volvulus Neuropeptide F receptor homolog 0.0015 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0129 0.0129
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0159 0.217
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Echinococcus granulosus 7tm_1 domain containing protein 0.0015 0.0007 0.0007
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0345 0.0345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0075 0.0162 0.1973
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0159 0.0159
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0022 0.0186
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.006 0.006
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Plasmodium falciparum glutathione reductase 0.01 0.0227 1
Onchocerca volvulus Alhambra homolog 0.0029 0.0044 0.0044
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0007 0.0007
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0147 0.0346 0.0346
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Schistosoma mansoni glycogen phosphorylase 0.0143 0.0338 0.0338
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0025 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0007 0.0007
Echinococcus granulosus somatostatin receptor 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0147 0.0346 0.0346
Brugia malayi ORL1-like opioid receptor 0.0015 0.0007 0.0007
Brugia malayi Dopamine receptor protein 2 0.0015 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0034 0.1474
Loa Loa (eye worm) glycogen phosphorylase 0.0331 0.0821 0.0821
Echinococcus granulosus 7TM GPCR rhodopsin 0.0015 0.0007 0.0007
Schistosoma mansoni DNA polymerase eta 0.002 0.0022 0.0022
Trypanosoma cruzi C-8 sterol isomerase, putative 0.3074 0.7865 1
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0007 0.0007
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0227 0.0227
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0159 0.1347
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0007 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0121 0.0121
Echinococcus multilocularis glycogen phosphorylase 0.0331 0.0821 0.0821
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0007 0.0007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) glutaminase 2 0.0266 0.0652 0.0652
Onchocerca volvulus 0.0015 0.0007 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0121 0.1469
Loa Loa (eye worm) hypothetical protein 0.3074 0.7865 0.7865
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0164 0.0164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Brugia malayi jmjC domain containing protein 0.0035 0.006 0.006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.0556 0.4722
Schistosoma mansoni ap endonuclease 0.0059 0.0121 0.0121
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0129 0.0128
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0059 0.0074
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0059 0.0583
Onchocerca volvulus 0.0015 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0075 0.0162 0.1973
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0015 0.0007 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0121 0.0121
Echinococcus multilocularis glycogen phosphorylase 0.0331 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0016
Brugia malayi hypothetical protein 0.025 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni opsin-like receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0214 0.0213
Entamoeba histolytica glycogen phosphorylase, putative 0.0331 0.0821 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Mycobacterium ulcerans glutaminase 0.0266 0.0652 1
Brugia malayi beta-lactamase family protein 0.0074 0.0159 0.0159
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0015 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.056 0.1408 0.1408
Toxoplasma gondii exonuclease III APE 0.0059 0.0121 0.5321
Echinococcus multilocularis dro:myosuppressin receptor 0.0015 0.0007 0.0007
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.0338 0.4113
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0007
Echinococcus multilocularis serotonin receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0015 0.0007 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0076 0.333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus multilocularis dna polymerase kappa 0.002 0.0022 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0009 0.0361
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0431 0.1076 0.1076
Echinococcus multilocularis neuropeptide receptor A26 0.0015 0.0007 0.0007
Echinococcus granulosus fmrfamide receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0345 0.0345
Trichomonas vaginalis glycogen phosphorylase, putative 0.0331 0.0821 0.6679
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0034 0.0034
Schistosoma mansoni neuropeptide receptor 0.0015 0.0007 0.0007
Trichomonas vaginalis glutaminase, putative 0.0266 0.0652 0.5303
Loa Loa (eye worm) hypothetical protein 0.1571 0.4005 0.4005
Brugia malayi sulfakinin receptor protein 0.0015 0.0007 0.0007
Plasmodium falciparum transporter, putative 0.0025 0.0034 0.1474
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0015 0.0007 0.0007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0059 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0028
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0034 0.0034
Schistosoma mansoni glycogen phosphorylase 0.0331 0.0821 0.0821
Brugia malayi hypothetical protein 0.0025 0.0034 0.0034
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0059 0.0074
Leishmania major DNA polymerase kappa, putative 0.002 0.0022 0.0028
Echinococcus multilocularis serotonin receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0124 0.0123
Leishmania major C-8 sterol isomerase-like protein 0.3074 0.7865 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.3074 0.7865 0.7865
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0129 0.0128
Plasmodium vivax amine transporter, putative 0.0025 0.0034 0.1474
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0059
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0007 0.0007
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0001 0.0001
Brugia malayi beta-lactamase family protein 0.0074 0.0159 0.0159
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0227 0.0227
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0121 0.1567
Trypanosoma brucei unspecified product 0.002 0.0022 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0121 1
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0059 0.0477
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0015 0.0007 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0076 0.0075
Schistosoma mansoni neuropeptide f receptor 76f 0.0015 0.0007 0.0007
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0015 0.0007 0.0007
Schistosoma mansoni vesicular amine transporter 0.0187 0.0451 0.0451
Echinococcus granulosus vesicular acetylcholine transporter 0.3906 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0015 0.0007 0.0007
Leishmania major DNA polymerase eta, putative 0.002 0.0022 0.0028
Onchocerca volvulus 0.0025 0.0034 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0034
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0007 0.0007
Echinococcus granulosus g-protein coupled receptor 0.0015 0.0007 0.0007
Brugia malayi Dopamine receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0007 0.0007
Mycobacterium ulcerans beta-lactamase 0.0074 0.0159 0.217
Echinococcus granulosus neuropeptide s receptor 0.0015 0.0007 0.0007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0121 0.0153
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0159 0.129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.0556 0.4722
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0059 0.0074
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0159 0.1347
Entamoeba histolytica hypothetical protein 0.0075 0.0162 0.1973
Echinococcus granulosus g protein coupled receptor 0.0015 0.0007 0.0007
Treponema pallidum NADH oxidase 0.0035 0.0059 0.0818
Brugia malayi larval opioid receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0129 0.0128
Toxoplasma gondii hypothetical protein 0.0025 0.0034 0.1474
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0022 0.0022
Giardia lamblia DINP protein human, muc B family 0.002 0.0022 0.0266
Echinococcus granulosus neuropeptide receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.06 uM Binding affinity against human IMR 90 fetal lung fibroblast bradykinin receptor B2 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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