Detailed information for compound 104570

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.227 | Formula: C12H13F2N4O4P
  • H donors: 3 H acceptors: 6 LogP: -0.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c(F)cccc1F)NC(CP(=O)(O)O)Cn1cncn1
  • InChi: 1S/C12H13F2N4O4P/c13-9-2-1-3-10(14)11(9)12(19)17-8(5-23(20,21)22)4-18-7-15-6-16-18/h1-3,6-8H,4-5H2,(H,17,19)(H2,20,21,22)
  • InChiKey: HAYUMHIMPPDLDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cryptococcus neoformans var. neoformans B-3501A Imidazoleglycerol-phosphate dehydratase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Nanchung homolog Imidazoleglycerol-phosphate dehydratase   202 aa 162 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dnaJ subfamily B 0.0401 0.1982 0.1982
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0037 0.0229
Echinococcus multilocularis glutamate receptor 2 0.0019 0.0044 0.0044
Schistosoma mansoni tyrosine protein kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0011 0.0005 0.0005
Echinococcus granulosus GPCR family 3 C terminal 0.0033 0.0114 0.0114
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.0534 0.152
Echinococcus multilocularis tyrosine protein kinase csk 0.0011 0.0005 0.0005
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0437 0.0437
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0112 0.0699
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0037 0.0108
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0037 0.0037
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0037 0.0229
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni vesicular amine transporter 0.0012 0.001 0.001
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.0534 0.152
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0062 0.0057
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0011 0.0005 0.0005
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0112 0.5476
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0599 0.1713
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0112 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0037 0.0229
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0011 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0033 0.0114 0.0114
Brugia malayi Metabotropic glutamate receptor precursor. 0.0202 0.0972 0.0968
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0018 0.0053
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0011 0.0005 0.0005
Echinococcus multilocularis activin receptor type 0.0011 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Echinococcus granulosus raf serine:threonine protein kinase 0.0011 0.0005 0.0005
Brugia malayi isocitrate dehydrogenase 0.0032 0.0112 0.0107
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0037 0.0229
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0011 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0018 0.0053
Schistosoma mansoni hypothetical protein 0.004 0.015 0.015
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0018 0.0053
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1065 0.5349 0.5349
Echinococcus multilocularis heat shock protein 70 0.0011 0.0005 0.0005
Plasmodium falciparum tyrosine kinase-like protein 0.0011 0.0005 0.0236
Echinococcus granulosus fibroblast growth factor receptor 4 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Echinococcus multilocularis protein tyrosine kinase 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0039
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0018 0.0053
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0033
Echinococcus granulosus neuroglian 0.0012 0.001 0.001
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0026 0.0021
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Schistosoma mansoni hypothetical protein 0.0014 0.0018 0.0018
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0037 0.1794
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0101 0.0096
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0112 0.0699
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0025
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Leishmania major cytochrome p450-like protein 0.0014 0.0018 0.0112
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0326 0.1604 0.1599
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.0633 0.316 0.316
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0037 0.2085
Schistosoma mansoni ephrin receptor 0.0011 0.0005 0.0005
Onchocerca volvulus Poor gastrulation protein homolog 0.0033 0.0114 0.1977
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0087 0.0082
Echinococcus multilocularis FL cytokine receptor 0.0011 0.0005 0.0005
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0011 0.0005 0.0005
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0027 0.0087 0.0082
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0205 0.02
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0011 0.0005 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0039
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0062 0.0384
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0018 0.0053
Entamoeba histolytica receptor protein kinase, putative 0.0011 0.0005 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Echinococcus granulosus roundabout 2 0.0016 0.003 0.003
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0112 0.0699
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0112 0.0112
Echinococcus multilocularis kinase suppressor of Ras 1 0.0011 0.0005 0.0005
Schistosoma mansoni serine/threonine RGC 0.0011 0.0005 0.0005
Leishmania major 0.0326 0.1604 1
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Brugia malayi Guanylyl cyclase protein 23 0.003 0.0101 0.0096
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0018 0.0053
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0037 0.0229
Plasmodium falciparum protein kinase, putative 0.0011 0.0005 0.0236
Brugia malayi Cytochrome P450 family protein 0.0051 0.0208 0.0203
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0018 0.0053
Entamoeba histolytica tyrosin kinase, putative 0.0011 0.0005 0.011
Echinococcus granulosus lamin 0.0029 0.0094 0.0094
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0011 0.0005 0.0005
Schistosoma mansoni cytochrome P450 0.0014 0.0018 0.0018
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0011 0.0005 0.003
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0158 0.0158
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni intermediate filament proteins 0.0029 0.0094 0.0094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0219 0.0214
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.0337 0.1657 1
Schistosoma mansoni protein kinase 0.003 0.0101 0.0101
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0112 0.0112
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0011 0.0005 0.0005
Echinococcus granulosus GPCR family 2 0.0017 0.0033 0.0033
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0005
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0011 0.0005 0.0005
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0011 0.0005 0.003
Loa Loa (eye worm) cytochrome P450 0.0014 0.0018 0.0013
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Toxoplasma gondii protein kinase domain-containing protein 0.0011 0.0005 0.003
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0052 0.021 0.0206
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus granulosus glutamate receptor 2 0.0019 0.0044 0.0044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0033
Echinococcus granulosus tyrosine protein kinase csk 0.0011 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0074 0.0322 0.7368
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0033
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0011 0.0005 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0005 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0599 0.1713
Brugia malayi cytochrome P450 0.0014 0.0018 0.0013
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0011 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis glutamate receptor 2 0.0019 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase HCK 0.0011 0.0005 0.0005
Schistosoma mansoni patched 1 0.0041 0.0158 0.0158
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0326 0.1604 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0599 0.3549
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0037 0.1794
Echinococcus granulosus activated cdc42 kinase 1 0.0011 0.0005 0.0005
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0437 0.0437
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0019 0.0044 0.0044
Plasmodium falciparum thioredoxin reductase 0.0051 0.0205 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0052 0.021 0.0206
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0326 0.1604 0.1604
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0158 1
Echinococcus multilocularis tyrosine protein kinase 0.0011 0.0005 0.0005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0037 0.0108
Echinococcus multilocularis protein KINase family member (kin 25) 0.0011 0.0005 0.0005
Leishmania major protein kinase, putative 0.0011 0.0005 0.003
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0018 0.0053
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0019 0.0044 0.0044
Echinococcus multilocularis natriuretic peptide receptor 1 0.0011 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0011 0.0005 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0094 0.0089
Onchocerca volvulus 0.0029 0.0094 0.162
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0014
Echinococcus multilocularis c src tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0019 0.0044 0.0044
Entamoeba histolytica ankyrin repeat protein 0.0011 0.0005 0.011
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0033 0.0029
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0005 0.011
Echinococcus multilocularis neuroglian 0.0012 0.001 0.001
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0019 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Probable reductase 0.0116 0.0534 0.152
Echinococcus multilocularis GPCR, family 3, C terminal 0.0033 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0089
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0011 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Brugia malayi Protein kinase domain containing protein 0.0633 0.316 0.3157
Brugia malayi Fibronectin type III domain containing protein 0.0012 0.001 0.0005
Echinococcus multilocularis integrin linked protein kinase 0.0011 0.0005 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0218 0.1361
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0018 0.0112
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0019 0.0044 0.0044
Brugia malayi hypothetical protein 0.0019 0.0044 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Brugia malayi Cytochrome P450 family protein 0.0022 0.0062 0.0057
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.0101 0.0101
Echinococcus granulosus tyrosine protein kinase csk 0.0011 0.0005 0.0005
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Trypanosoma cruzi protein kinase, putative 0.0011 0.0005 0.003
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0011 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0005 0.0005
Echinococcus granulosus nmda type glutamate receptor 0.0019 0.0044 0.0044
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Plasmodium falciparum tyrosine kinase-like protein 0.0011 0.0005 0.0236
Echinococcus multilocularis 0.0014 0.0018 0.0018
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis lamin 0.0029 0.0094 0.0094
Echinococcus multilocularis cpg binding protein 0.003 0.0099 0.0099
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0011 0.0005 0.003
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0012 0.001 0.001
Echinococcus multilocularis Immunoglobulin 0.0012 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0005 0.0005
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0633 0.316 0.316
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Echinococcus granulosus tyrosine protein kinase csk 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0053 0.0219 0.0214
Schistosoma mansoni tyrosine kinase 0.003 0.0101 0.0101
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0011 0.0005 0.0005
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Schistosoma mansoni lamin 0.0029 0.0094 0.0094
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0011 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0011 0.0005 0.0005
Leishmania major protein kinase, putative 0.0011 0.0005 0.003
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0037 0.5
Schistosoma mansoni hypothetical protein 0.004 0.015 0.015
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Loa Loa (eye worm) glutathione reductase 0.0051 0.0205 0.02
Onchocerca volvulus 0.0028 0.009 0.1551
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0011 0.0005 0.0005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0037 0.0133 0.0133
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0011 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0019 0.0044 0.1006
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0011 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.004 0.015 0.015
Plasmodium vivax tyrosine kinase-like protein, putative 0.0011 0.0005 0.0236
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0158 0.0158
Echinococcus multilocularis lamin dm0 0.0029 0.0094 0.0094
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0112 0.0699
Trypanosoma cruzi extracellular receptor, putative 0.0019 0.0044 0.0274
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0169 0.0806 0.0806
Echinococcus granulosus natriuretic peptide receptor 1 0.0011 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0062 0.018
Trypanosoma brucei Flagellum attachment zone protein 20 0.0011 0.0005 0.003
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0037 0.0229
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0011 0.0005 0.011
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0011 0.0005 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0322 0.0322
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0018 0.0112
Loa Loa (eye worm) hypothetical protein 0.0249 0.1209 0.1205
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0133 0.0128
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0029
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0018 0.0018
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0037 0.0229
Toxoplasma gondii thioredoxin reductase 0.0051 0.0205 0.1277
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0018 0.0053
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0094 0.0089
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0037 0.0055
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0326 0.1604 1
Schistosoma mansoni metabotropic glutamate receptor 0.0169 0.0806 0.0806
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0037 0.0229
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0025
Echinococcus granulosus glutamate receptor 2 0.0019 0.0044 0.0044
Schistosoma mansoni cpg binding protein 0.0028 0.009 0.009
Echinococcus granulosus epidermal growth factor receptor 0.1982 1 1
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0326 0.1604 0.1604
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0037 0.1794
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0121 0.0563 0.3514
Echinococcus granulosus tyrosine protein kinase Src42A 0.0011 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0005 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0219 0.0214
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0011 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis ephrin type A receptor 4 A 0.0011 0.0005 0.0005
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0018 0.0053
Echinococcus multilocularis nmda type glutamate receptor 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0011
Entamoeba histolytica hypothetical protein 0.0074 0.0322 0.7368
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Plasmodium falciparum protein kinase, putative 0.0011 0.0005 0.0236
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase pr2 0.0011 0.0005 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0219 0.0214
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.009 0.0086
Echinococcus multilocularis tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0011 0.0005 0.0005
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0018 0.0053
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0011 0.0005 0.003
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0112 0.0699
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0005 0.011
Loa Loa (eye worm) hypothetical protein 0.012 0.0557 0.0552
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0018 0.0053
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0011 0.0005 0.003
Schistosoma mansoni tyrosine kinase 0.1053 0.5292 0.5292
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0018 0.0112
Schistosoma mansoni tyrosine kinase 0.1065 0.5349 0.5349
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0018 0.0053
Echinococcus multilocularis tyrosine protein kinase Abl 0.0011 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0005
Onchocerca volvulus 0.0019 0.0044 0.071
Brugia malayi hypothetical protein 0.0074 0.0322 0.0317
Echinococcus granulosus activin receptor type 0.0011 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase shark 0.0011 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus granulosus cpg binding protein 0.003 0.0099 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0037 0.0229
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0033 0.0033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.0534 0.152
Echinococcus granulosus lamin dm0 0.0029 0.0094 0.0094
Brugia malayi CXXC zinc finger family protein 0.0028 0.009 0.0086
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni hypothetical protein 0.004 0.015 0.015
Echinococcus granulosus retinal guanylyl cyclase 2 0.0011 0.0005 0.0005
Echinococcus multilocularis activated cdc42 kinase 1 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.012 0.0557 0.0552
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0112 0.0112
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Entamoeba histolytica tyrosin kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0205 0.0205
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0599 0.1713
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0121 0.0563 0.3514
Echinococcus granulosus intermediate filament protein 0.0029 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0005
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0114 0.0109
Schistosoma mansoni cell adhesion molecule 0.0016 0.003 0.003
Echinococcus granulosus c src tyrosine kinase 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0052 0.021 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0037 0.0229
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0037 0.0229
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Schistosoma mansoni hypothetical protein 0.0401 0.1982 0.1982
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.0534 0.3149
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Trypanosoma brucei Pseudokinase, putative 0.0011 0.0005 0.003
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0112 0.0699
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Entamoeba histolytica tyrosin kinase, putative 0.0011 0.0005 0.011
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Echinococcus granulosus insulin receptor 0.0633 0.316 0.316
Echinococcus granulosus protein kinase 0.0011 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0062 0.0384
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0011 0.0005 0.011
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0112 0.0107
Leishmania major extracellular receptor, putative 0.0019 0.0044 0.0274
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0018 0.0018
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0011 0.0005 0.0005
Onchocerca volvulus 0.0029 0.0094 0.162
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0112 0.0112
Echinococcus granulosus Immunoglobulin 0.0012 0.001 0.001
Leishmania major cytochrome p450-like protein 0.0022 0.0062 0.0384
Entamoeba histolytica hypothetical protein 0.0074 0.0322 0.7368
Toxoplasma gondii STE kinase 0.0011 0.0005 0.003
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0011 0.0005 0.0005
Echinococcus multilocularis Immunoglobulin 0.0012 0.001 0.001
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0647 0.0647
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0326 0.1604 1
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0037 0.0037
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0011 0.0005 0.0005
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Trypanosoma cruzi protein kinase, putative 0.0011 0.0005 0.003
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Echinococcus multilocularis tyrosine protein kinase shark 0.0011 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.0005 0.0005
Toxoplasma gondii fructose-bisphospatase II 0.0326 0.1604 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Entamoeba histolytica tyrosin kinase, putative 0.0011 0.0005 0.011
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0011 0.0005 0.0005
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0005
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0018 0.0053
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0205 0.0205
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0121 0.0563 0.3514
Brugia malayi CHE-14 protein 0.0041 0.0158 0.0153
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Echinococcus multilocularis protein kinase 0.0011 0.0005 0.0005
Loa Loa (eye worm) TK/EGFR protein kinase 0.1982 1 1
Echinococcus granulosus atrial natriuretic peptide receptor 0.0019 0.0044 0.0044
Echinococcus multilocularis epidermal growth factor receptor 0.1065 0.5349 0.5349
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0018 0.0053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0011
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Entamoeba histolytica receptor protein kinase, putative 0.0011 0.0005 0.011
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0016 0.003 0.003
Echinococcus multilocularis transfer RNA-Thr 0.0011 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Src64B 0.0011 0.0005 0.0005
Echinococcus multilocularis GPCR, family 2 0.0017 0.0033 0.0033
Brugia malayi Receptor family ligand binding region containing protein 0.0052 0.021 0.0206
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0121 0.0563 0.3514
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.001 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0005 0.0005
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0445 0.2207 0.2207
Echinococcus multilocularis tyrosine kinase 0.003 0.0101 0.0101
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0037 0.0229
Schistosoma mansoni tyrosine kinase 0.0633 0.316 0.316
Leishmania major trypanothione reductase 0.0051 0.0205 0.1277
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.0534 0.152
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0011 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase HCK 0.0011 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0011 0.0005 0.0005
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.1053 0.5292 0.5292
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0033 0.0114 0.0109
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Echinococcus multilocularis tyrosine protein kinase Srms 0.0011 0.0005 0.0005
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0019 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase csk 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Echinococcus granulosus twitchin 0.0012 0.001 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0037 0.0108
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1664 0.8388 0.8388
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0437 0.0433
Echinococcus multilocularis raf serine:threonine protein kinase 0.0011 0.0005 0.0005
Entamoeba histolytica ankyrin repeat protein 0.0011 0.0005 0.011
Echinococcus multilocularis protein kinase 0.0011 0.0005 0.0005
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0112 0.0107
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0018 0.0053
Plasmodium falciparum protein kinase, putative 0.0011 0.0005 0.0236
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0005
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.003 0.0101 0.0101
Echinococcus granulosus ephrin type A receptor 4 A 0.0011 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase csk 0.0011 0.0005 0.0005
Onchocerca volvulus Huntingtin homolog 0.012 0.0557 1
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0033 0.0114 0.1977
Toxoplasma gondii fructose-bisphospatase I 0.0121 0.0563 0.3514
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.023 0.1113 0.1113
Loa Loa (eye worm) glutamate receptor 0.0079 0.0351 0.0346
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0018 0.0112
Schistosoma mansoni lamin 0.0029 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0005
Brugia malayi glutathione reductase 0.0051 0.0205 0.02
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0033 0.0033
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0037 0.2085
Plasmodium falciparum glutathione reductase 0.0051 0.0205 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.003 0.0101 0.1746
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0112 0.0277
Schistosoma mansoni hypothetical protein 0.0074 0.0322 0.0322
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0037 0.1794
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0018 0.0018
Schistosoma mansoni tyrosine kinase 0.1053 0.5292 0.5292
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0445 0.0445
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0018 0.0112
Echinococcus multilocularis roundabout 2 0.0016 0.003 0.003
Schistosoma mansoni metabotropic glutamate receptor 0.0098 0.0447 0.0447
Echinococcus multilocularis insulin receptor 0.0633 0.316 0.316
Echinococcus granulosus expressed conserved protein 0.0091 0.0408 0.0408
Echinococcus granulosus protein tyrosine kinase 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.0015 0.0025 0.0025
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0158 0.0158
Trypanosoma brucei trypanothione reductase 0.0051 0.0205 0.1277
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0018 0.0112
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0101 0.0096
Echinococcus multilocularis expressed conserved protein 0.0091 0.0408 0.0408
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0037 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Plasmodium vivax glutathione reductase, putative 0.0051 0.0205 1
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0005 0.011
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0101 0.0096
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0033 0.0029
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0112 0.0699
Echinococcus granulosus activated cdc42 kinase 1 0.0011 0.0005 0.0005
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0094 0.0089
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0019 0.0044 0.0044
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0039
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.0534 0.152
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0249 0.1209 0.1209
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0062 0.0384
Plasmodium falciparum glutathione reductase 0.0018 0.0037 0.1794
Brugia malayi hypothetical protein 0.012 0.0557 0.0552
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0112 0.5476
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0025
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0011 0.0005 0.0005
Brugia malayi hypothetical protein 0.0012 0.001 0.0005
Schistosoma mansoni glutamate receptor NMDA 0.0019 0.0044 0.0044
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.0101 0.0101
Echinococcus granulosus tyrosine protein kinase Srms 0.0011 0.0005 0.0005
Onchocerca volvulus 0.003 0.0101 0.1746
Brugia malayi Thioredoxin reductase 0.0051 0.0205 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0037 0.0229
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0101 0.0096
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0033 0.0029
Echinococcus granulosus metabotropic glutamate receptor 5 0.0249 0.1209 0.1209
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0019 0.0044 0.0044
Brugia malayi Cytochrome P450 family protein 0.0022 0.0062 0.0057
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis protein patched 0.0041 0.0158 0.0158
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0018 0.0053
Leishmania major hypothetical protein, conserved 0.0011 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0128
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0326 0.1604 0.1604
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0208 0.0203
Entamoeba histolytica hypothetical protein 0.0074 0.0322 0.7368
Echinococcus granulosus epidermal growth factor receptor 0.1065 0.5349 0.5349
Loa Loa (eye worm) TK/INSR protein kinase 0.0633 0.316 0.3157
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0251 0.0251
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0011 0.0005 0.003
Echinococcus granulosus tyrosine kinase 0.003 0.0101 0.0101
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Loa Loa (eye worm) hypothetical protein 0.0097 0.0437 0.0433
Echinococcus multilocularis 0.0613 0.3059 0.3059
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0037 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0205 0.055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0037 0.0229
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0039
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0012 0.001 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0112 0.0112
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis musashi 0.0029 0.0094 0.0094
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0437 1
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni tyrosine kinase 0.1982 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0011 0.0005 0.0005
Plasmodium vivax tyrosine kinase-like protein, putative 0.0011 0.0005 0.0236
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Echinococcus granulosus tyrosine protein kinase ABL1 0.0011 0.0005 0.0005
Echinococcus granulosus metabotropic glutamate receptor 2 0.0169 0.0806 0.0806
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0012 0.001 0.001
Echinococcus granulosus tyrosine protein kinase pr2 0.0011 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0037 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0039
Schistosoma mansoni tyrosine kinase 0.1065 0.5349 0.5349
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0018 0.0053
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.1982 0.1982
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0062 0.0057
Schistosoma mansoni ephrin receptor 0.0011 0.0005 0.0005
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0158 0.0153
Echinococcus multilocularis tyrosine protein kinase csk 0.0011 0.0005 0.0005
Brugia malayi intermediate filament protein 0.0029 0.0094 0.0089
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0019 0.0044 0.0044
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0037 0.0229
Toxoplasma gondii protein kinase 0.0011 0.0005 0.003
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0011 0.0005 0.011
Leishmania major cytochrome p450-like protein 0.0014 0.0018 0.0112
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0013 0.0008
Plasmodium vivax protein kinase, putative 0.0011 0.0005 0.0236
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0037 0.5
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0037 0.0229
Echinococcus granulosus tyrosine protein kinase Blk 0.0011 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0011 0.0005 0.011
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0011 0.0005 0.0005
Echinococcus granulosus retinal guanylyl cyclase 2 0.0011 0.0005 0.0005
Echinococcus granulosus tyrosine kinase 0.0011 0.0005 0.0005
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0092 0.0087
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0037 0.0229
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0019 0.0044 0.0039
Echinococcus granulosus kinase suppressor of Ras 1 0.0011 0.0005 0.0005
Entamoeba histolytica cysteine surface protein, putative 0.0011 0.0005 0.011
Schistosoma mansoni protein tyrosine kinase 0.0011 0.0005 0.0005
Echinococcus granulosus defective proboscis extension response 0.0012 0.001 0.001
Echinococcus granulosus tyrosine kinase 0.0011 0.0005 0.0005
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Echinococcus multilocularis tyrosine protein kinase Blk 0.0011 0.0005 0.0005
Onchocerca volvulus Huntingtin homolog 0.012 0.0557 1
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0205 0.1277
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0322 0.0322
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0041 0.0158 0.0153
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0005 0.0005
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0062 0.0057
Loa Loa (eye worm) glutamate receptor 0.0202 0.0972 0.0968
Echinococcus granulosus retinal guanylyl cyclase 2 0.0011 0.0005 0.0005
Brugia malayi Cytochrome P450 family protein 0.0014 0.0018 0.0013
Trypanosoma brucei protein kinase, putative 0.0011 0.0005 0.003
Brugia malayi fructose-1,6-bisphosphatase 0.0326 0.1604 0.1599
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0011 0.0005 0.0005
Schistosoma mansoni protein kinase 0.0011 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0033
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0011 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0039
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.0683 0.3413 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0101 0.0096
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0019 0.0044 0.0039
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0013 0.0008
Plasmodium falciparum thioredoxin reductase 0.0018 0.0037 0.1794
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0037 0.0229
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0005 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0005 0.0005
Brugia malayi metabotropic glutamate receptor type 2 0.0098 0.0447 0.0443
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Echinococcus multilocularis epidermal growth factor receptor 0.1982 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0005 0.011
Echinococcus multilocularis protein dispatched 1 0.0047 0.0187 0.0187
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0205 1
Echinococcus granulosus integrin linked protein kinase 0.0011 0.0005 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0033 0.0033
Schistosoma mansoni tyrosine kinase 0.0011 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0018 0.0053
Schistosoma mansoni nephrin 0.0012 0.001 0.001
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0018 0.0053
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0633 0.316 0.316
Loa Loa (eye worm) hypothetical protein 0.0051 0.0205 0.02
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0005 0.011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0037 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0011 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0011 0.0005 0.011
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.0683 0.3413 1
Treponema pallidum NADH oxidase 0.0018 0.0037 0.5
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0183 0.0876 0.0872

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.6 uM Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans ChEMBL. 10450980
IC50 (binding) = 4.6 uM Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans ChEMBL. 10450980
Ki (binding) = 1.15 uM Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans ChEMBL. 10450980
Ki (binding) = 1.15 uM Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans ChEMBL. 10450980
Kis (binding) = 5.8 uM Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) ChEMBL. 10450980
Kis (binding) = 5.8 uM Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) ChEMBL. 10450980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.