Detailed information for compound 1051915

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 330.378 | Formula: C18H22N2O4
  • H donors: 0 H acceptors: 1 LogP: 1.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1occ(n1)CN1CCC2(CC1)OCCO2
  • InChi: 1S/C18H22N2O4/c1-21-16-4-2-3-14(11-16)17-19-15(13-22-17)12-20-7-5-18(6-8-20)23-9-10-24-18/h2-4,11,13H,5-10,12H2,1H3
  • InChiKey: POQFACGXMASBND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.033 0.1805 0.6062
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0071 0.0471
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0282 0.0282
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0249 0.1346 0.4509
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0111 0.0564 0.6849
Brugia malayi Cytochrome P450 family protein 0.0111 0.0564 0.1896
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0111
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Brugia malayi Serotonin/octopamine receptor family protein 7 0.033 0.1805 0.6062
Echinococcus granulosus tm gpcr rhodopsin 0.033 0.1805 0.2582
Schistosoma mansoni cpg binding protein 0.0028 0.0092 0.0092
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0111 0.0564 0.5429
Echinococcus granulosus neuropeptide receptor A26 0.033 0.1805 0.2582
Schistosoma mansoni neuropeptide receptor 0.033 0.1805 0.1805
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0111
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0021 0.0053 0.0177
Leishmania major protein kinase, putative 0.0249 0.1346 0.4509
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0114 0.0579 0.0828
Brugia malayi putative neuropeptide receptor NPR1 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni cell adhesion molecule 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0068 0.032 0.1076
Entamoeba histolytica serine/threonine protein kinase, putative 0.0536 0.2977 1
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0213 0.1146 0.385
Brugia malayi Dopamine receptor protein 1 0.033 0.1805 0.6062
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.033 0.1805 0.2582
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0282 0.0947
Brugia malayi serine/threonine-protein kinase 6 0.0249 0.1346 0.4523
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0111 0.0564 0.6849
Schistosoma mansoni hypothetical protein 0.0111 0.0564 0.0564
Trypanosoma brucei cytochrome P450, putative 0.0189 0.1008 0.3369
Echinococcus granulosus neuropeptide Y receptor 0.033 0.1805 0.2582
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.0931
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0249 0.1346 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.033 0.1805 0.1805
Schistosoma mansoni hypothetical protein 0.033 0.1805 0.1805
Echinococcus multilocularis roundabout 2 0.0015 0.0022 0.0031
Onchocerca volvulus 0.0012 0.0004 0.0012
Echinococcus granulosus biogenic amine 5HT receptor 0.033 0.1805 0.2582
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0111 0.0564 0.5429
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.159 0.533
Onchocerca volvulus 0.033 0.1805 0.6062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0038 0.0102
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Onchocerca volvulus Slit protein homolog 0.0017 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Trichomonas vaginalis CAMK family protein kinase 0.0536 0.2977 1
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus granulosus contactin 0.0015 0.0022 0.0031
Echinococcus multilocularis titin 0.0018 0.0034 0.0049
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0012 0.0004 0.0012
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.033 0.1805 0.6062
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0249 0.1346 0.4509
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Onchocerca volvulus Neuropeptide F receptor homolog 0.033 0.1805 0.6062
Schistosoma mansoni protein kinase 0.0013 0.0008 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0282 0.0947
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0015 0.0022 0.0022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0092 0.031
Schistosoma mansoni protein kinase 0.0013 0.0008 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0022 0.0074
Onchocerca volvulus 0.033 0.1805 0.6062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.033 0.1805 0.2582
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0168 0.0539
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Brugia malayi TAR-binding protein 0.0061 0.0282 0.0947
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.033 0.1805 0.2582
Echinococcus multilocularis roundabout 2 0.0015 0.0022 0.0031
Schistosoma mansoni amine GPCR 0.033 0.1805 0.1805
Leishmania major cytochrome p450-like protein 0.0111 0.0564 0.1876
Schistosoma mansoni biogenic amine receptor 0.033 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni neuropeptide receptor 0.033 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Brugia malayi putative neuropeptide receptor 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Onchocerca volvulus 0.0018 0.0034 0.0116
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0249 0.1346 0.1927
Echinococcus multilocularis g-protein coupled receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0218 0.071
Echinococcus granulosus thyrotropin releasing hormone receptor 0.033 0.1805 0.2582
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0111
Echinococcus multilocularis neuropeptide FF receptor 2 0.033 0.1805 0.2582
Loa Loa (eye worm) neuropeptide F receptor 0.033 0.1805 0.6062
Brugia malayi ORL1-like opioid receptor 0.033 0.1805 0.6062
Echinococcus granulosus activin receptor type 0.0013 0.0008 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0186 0.0623
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0012 0.0004 0.0005
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0111 0.0564 0.5429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0277 0.0931
Brugia malayi cytochrome P450 0.0111 0.0564 0.1896
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0111 0.0564 0.6849
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Onchocerca volvulus 0.033 0.1805 0.6062
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.033 0.1805 0.2582
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0536 0.2977 0.4259
Schistosoma mansoni opsin-like receptor 0.033 0.1805 0.1805
Echinococcus granulosus sex peptide receptor 0.033 0.1805 0.2582
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.033 0.1805 0.2582
Echinococcus granulosus dro:myosuppressin receptor 0.033 0.1805 0.2582
Onchocerca volvulus 0.033 0.1805 0.6062
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0038 0.0054
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0068 0.032 0.1076
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0111 0.0564 0.5429
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0004 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0536 0.2977 1
Trichomonas vaginalis CAMK family protein kinase 0.0536 0.2977 1
Echinococcus granulosus titin 0.0018 0.0034 0.0049
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.0022 0.0031
Leishmania major cytochrome p450-like protein 0.0189 0.1008 0.3369
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0118 0.0606 0.2037
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.1805 0.2582
Echinococcus granulosus tachykinin peptides receptor 99D 0.033 0.1805 0.2582
Schistosoma mansoni nephrin 0.0015 0.0022 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0186 0.0265
Brugia malayi Dopamine receptor protein 2 0.033 0.1805 0.6062
Brugia malayi GnHR receptor homolog 0.033 0.1805 0.6062
Schistosoma mansoni myosin-binding protein-related 0.0012 0.0004 0.0004
Echinococcus multilocularis fmrfamide receptor 0.033 0.1805 0.2582
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0111 0.0564 0.6849
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.033 0.1805 0.1805
Echinococcus multilocularis neuroglian 0.0015 0.0022 0.0031
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0038 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0111 0.0564 0.6849
Schistosoma mansoni biogenic amine (5HT) receptor 0.033 0.1805 0.1805
Schistosoma mansoni biogenic amine (dopamine) receptor 0.033 0.1805 0.1805
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0038 0.0102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.033 0.1805 0.1805
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.033 0.1805 0.1805
Trichomonas vaginalis CAMK family protein kinase 0.0536 0.2977 1
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0111
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0111 0.0564 0.1876
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.1805 0.2582
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0186 0.0265
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.033 0.1805 0.2582
Brugia malayi hypothetical protein 0.0118 0.0606 0.2037
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.033 0.1805 0.6062
Echinococcus multilocularis alpha 1A adrenergic receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Loa Loa (eye worm) cytochrome P450 family protein 0.0189 0.1008 0.3386
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.033 0.1805 0.1805
Schistosoma mansoni neuropeptide receptor 0.033 0.1805 0.1805
Schistosoma mansoni cpg binding protein 0.0029 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0111 0.0564 0.6849
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.033 0.1805 0.1805
Echinococcus granulosus 7tm_1 domain containing protein 0.033 0.1805 0.2582
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0013 0.0008 0.0011
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.033 0.1805 0.2582
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.0931
Echinococcus granulosus neuropeptides capa receptor 0.033 0.1805 0.2582
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0114 0.0579 0.0828
Loa Loa (eye worm) projectin 0.0012 0.0004 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0111 0.0564 0.6849
Toxoplasma gondii cytochrome p450 superfamily protein 0.0111 0.0564 0.416
Schistosoma mansoni cpg binding protein 0.0029 0.0101 0.0101
Echinococcus granulosus tm gpcr rhodopsin 0.033 0.1805 0.2582
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0038 0.0102
Giardia lamblia Aurora kinase 0.0249 0.1346 0.4452
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.1805 0.2582
Echinococcus granulosus neuropeptide receptor 0.033 0.1805 0.2582
Onchocerca volvulus 0.0012 0.0004 0.0012
Echinococcus granulosus aurora kinase A 0.0249 0.1346 0.1927
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0111
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.033 0.1805 0.1805
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.159 0.533
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis neuropeptides capa receptor 0.033 0.1805 0.2582
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0111 0.0564 0.6849
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0012 0.0004 0.0012
Onchocerca volvulus 0.033 0.1805 0.6062
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0282 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0111 0.0564 0.6849
Schistosoma mansoni titin 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni growth hormone secretagogue receptor 0.033 0.1805 0.1805
Schistosoma mansoni neuropeptide F-like receptor 0.033 0.1805 0.1805
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0536 0.2977 0.4259
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.1346 0.1346
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.1805 0.2582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Echinococcus multilocularis orexin receptor type 2 0.033 0.1805 0.2582
Echinococcus multilocularis g protein coupled receptor 0.033 0.1805 0.2582
Echinococcus granulosus g-protein coupled receptor 0.033 0.1805 0.2582
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0015 0.0022 0.0031
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0111 0.0564 0.1876
Onchocerca volvulus 0.033 0.1805 0.6062
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0213 0.1146 0.385
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.033 0.1805 0.2582
Schistosoma mansoni cell adhesion molecule 0.0015 0.0022 0.0022
Echinococcus multilocularis aurora kinase A 0.0249 0.1346 0.1927
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0111 0.0564 0.6849
Plasmodium falciparum serine/threonine protein kinase, putative 0.0249 0.1346 1
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Brugia malayi hypothetical protein 0.0024 0.0071 0.0237
Echinococcus granulosus neuropeptide receptor 0.033 0.1805 0.2582
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0071 0.025
Entamoeba histolytica protein kinase , putative 0.0249 0.1346 0.4509
Schistosoma mansoni serine/threonine protein kinase 0.0536 0.2977 0.2977
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0111 0.0564 0.6849
Loa Loa (eye worm) TK/ROR protein kinase 0.0016 0.0024 0.008
Brugia malayi larval opioid receptor 0.033 0.1805 0.6062
Giardia lamblia Kinase, PLK 0.0536 0.2977 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Echinococcus granulosus peptide allatostatin:somatostatin 0.033 0.1805 0.2582
Echinococcus multilocularis peroxidasin 0.0012 0.0001 0.0002
Toxoplasma gondii aurora kinase 0.0249 0.1346 1
Trypanosoma cruzi cytochrome P450, putative 0.0189 0.1008 0.3369
Brugia malayi sulfakinin receptor protein 0.033 0.1805 0.6062
Schistosoma mansoni neuropeptide receptor 0.033 0.1805 0.1805
Brugia malayi Peroxidasin 0.0012 0.0001 0.0004
Onchocerca volvulus Huntingtin homolog 0.0118 0.0606 0.2037
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0111 0.0564 0.6849
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.033 0.1805 0.6062
Toxoplasma gondii hypothetical protein 0.0024 0.0071 0.0471
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0233 0.1684
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.1805 0.2582
Loa Loa (eye worm) TK protein kinase 0.0122 0.0626 0.2102
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0282 0.0282
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0038 0.0226
Echinococcus granulosus roundabout 2 0.0015 0.0022 0.0031
Brugia malayi Fibronectin type III domain containing protein 0.006 0.0277 0.0931
Echinococcus granulosus fmrfamide receptor 0.033 0.1805 0.2582
Echinococcus multilocularis serotonin receptor 0.033 0.1805 0.2582
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0038 0.0102
Toxoplasma gondii exonuclease III APE 0.0018 0.0038 0.0226
Loa Loa (eye worm) follicle stimulating hormone receptor 0.033 0.1805 0.6062
Trichomonas vaginalis AGC family protein kinase 0.0249 0.1346 0.4452
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0111 0.0564 0.1876
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Schistosoma mansoni alpha-1 adrenergic receptor 0.033 0.1805 0.1805
Brugia malayi serine/threonine-protein kinase plk-2 0.0536 0.2977 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0282 0.0282
Onchocerca volvulus 0.033 0.1805 0.6062
Echinococcus granulosus g protein coupled receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0022 0.0074
Echinococcus granulosus slit 2 protein 0.0017 0.003 0.0043
Echinococcus multilocularis neuropeptides capa receptor 0.033 0.1805 0.2582
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0536 0.2977 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0111 0.0564 0.5429
Brugia malayi serine/threonine protein kinase 6 0.0249 0.1346 0.4523
Echinococcus granulosus titin 0.0018 0.0034 0.0049
Schistosoma mansoni hypothetical protein 0.033 0.1805 0.1805
Onchocerca volvulus Serine\/threonine kinase homolog 0.0536 0.2977 1
Trichomonas vaginalis AGC family protein kinase 0.0249 0.1346 0.4452
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0111 0.0564 0.5429
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.1805 0.2582
Echinococcus multilocularis somatostatin receptor 0.033 0.1805 0.2582
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0111 0.0564 0.5429
Echinococcus granulosus fibroblast growth factor receptor 4 0.0114 0.0579 0.0828
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.033 0.1805 0.1805
Echinococcus granulosus tar DNA binding protein 0.0061 0.0282 0.0404
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0077 0.0258
Schistosoma mansoni biogenic amine receptor 0.033 0.1805 0.1805
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.033 0.1805 0.2582
Loa Loa (eye worm) AUR protein kinase 0.0249 0.1346 0.4523
Echinococcus granulosus allatostatin A receptor 0.033 0.1805 0.2582
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.033 0.1805 0.2582
Brugia malayi protein unc-22 0.0018 0.0034 0.0116
Onchocerca volvulus 0.0024 0.0071 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Echinococcus granulosus hypothetical protein 0.033 0.1805 0.2582
Schistosoma mansoni protein kinase 0.0249 0.1346 0.1346
Loa Loa (eye worm) AUR protein kinase 0.0249 0.1346 0.4523
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0111 0.0564 0.1876
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.1805 0.2582
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0114 0.0579 0.0828
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0718 0.2394
Loa Loa (eye worm) AUR protein kinase 0.0249 0.1346 0.4523
Schistosoma mansoni vesicular amine transporter 0.0056 0.0255 0.0255
Echinococcus multilocularis slit 2 protein 0.0017 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0038 0.0054
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0249 0.1346 0.1927
Brugia malayi G-protein coupled receptor 0.033 0.1805 0.6062
Loa Loa (eye worm) cytochrome P450 family protein 0.0451 0.2496 0.8385
Brugia malayi gonadotropin-releasing hormone receptor 2 0.033 0.1805 0.6062
Schistosoma mansoni neuropeptide f receptor 76f 0.033 0.1805 0.1805
Brugia malayi Serotonin receptor 0.033 0.1805 0.6062
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.033 0.1805 0.2582
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0807 1
Echinococcus granulosus defective proboscis extension response 0.0056 0.0255 0.0365
Trichomonas vaginalis CAMK family protein kinase 0.0536 0.2977 1
Loa Loa (eye worm) CAMK protein kinase 0.0018 0.0034 0.0116
Echinococcus granulosus neuroglian 0.0065 0.0302 0.0432
Echinococcus granulosus roundabout 2 0.0015 0.0022 0.0031
Loa Loa (eye worm) TYRA-2 protein 0.033 0.1805 0.6062
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0111 0.0564 0.5429
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0038 0.5
Schistosoma mansoni amine GPCR 0.033 0.1805 0.1805
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0038 0.0127
Brugia malayi Dopamine receptor 0.033 0.1805 0.6062
Echinococcus multilocularis G protein coupled receptor 139 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus granulosus cpg binding protein 0.0029 0.0101 0.0145
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0282 0.0404
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0718 0.2394
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0111 0.0564 0.6849
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0186 0.0186
Schistosoma mansoni opsin-like receptor 0.033 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis activin receptor type 0.0013 0.0008 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0186 0.0265
Echinococcus multilocularis biogenic amine (5HT) receptor 0.033 0.1805 0.2582
Brugia malayi Cytochrome P450 family protein 0.0451 0.2496 0.8385
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.1243 0.6989 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0168 0.0539
Loa Loa (eye worm) hypothetical protein 0.0078 0.0378 0.1271
Echinococcus granulosus orexin receptor type 2 0.033 0.1805 0.2582
Loa Loa (eye worm) neuropeptide F receptor 0.033 0.1805 0.6062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0186 0.0265
Echinococcus multilocularis neuropeptide Y receptor 0.033 0.1805 0.2582
Entamoeba histolytica protein kinase, putative 0.0249 0.1346 0.4509
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis serotonin receptor 0.033 0.1805 0.2582
Onchocerca volvulus Tyrosine kinase homolog 0.0162 0.0854 0.287
Brugia malayi serine/threonine kinase 12 0.0249 0.1346 0.4523
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.1805 0.2582
Onchocerca volvulus 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni peptide (allatostatin)-like receptor 0.033 0.1805 0.1805
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0038 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0186 0.0186
Echinococcus multilocularis neuropeptide Y receptor 0.033 0.1805 0.2582
Echinococcus granulosus tyrosine protein kinase Lyn 0.0013 0.0008 0.0011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.033 0.1805 0.2582
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Brugia malayi neuropeptide F receptor 0.033 0.1805 0.6062
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0111 0.0564 0.5429
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0022 0.0074
Onchocerca volvulus 0.0146 0.0765 0.2571
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.1805 0.2582
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0111 0.0564 0.5429
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.1805 0.2582
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0111 0.0564 0.6849
Loa Loa (eye worm) hypothetical protein 0.0056 0.0255 0.0857
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0056 0.0255 0.0365
Schistosoma mansoni biogenic amine (5HT) receptor 0.033 0.1805 0.1805
Leishmania major cytochrome p450-like protein 0.0111 0.0564 0.1876
Brugia malayi Cytochrome P450 family protein 0.0189 0.1008 0.3386
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.1243 0.6989 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0111
Echinococcus multilocularis cpg binding protein 0.0029 0.0101 0.0145
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0718 0.2394
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.033 0.1805 0.6062
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0111 0.0564 0.5429
Onchocerca volvulus 0.033 0.1805 0.6062
Schistosoma mansoni ap endonuclease 0.0018 0.0038 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0269 0.0269
Schistosoma mansoni tyrosine kinase 0.0019 0.0042 0.0042
Schistosoma mansoni titin 0.0018 0.0034 0.0034
Echinococcus multilocularis transfer RNA-Phe 0.0012 0.0004 0.0005
Schistosoma mansoni nephrin 0.0069 0.0324 0.0324
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0111 0.0564 0.6849
Brugia malayi G protein-coupled receptor F59B2.13 0.033 0.1805 0.6062
Schistosoma mansoni tyrosine kinase 0.0114 0.0579 0.0579
Echinococcus granulosus alpha 1A adrenergic receptor 0.033 0.1805 0.2582
Echinococcus granulosus cytochrome P450 2K1 0.0111 0.0564 0.0808
Schistosoma mansoni opsin-like receptor 0.033 0.1805 0.1805
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0111 0.0564 0.6849
Echinococcus multilocularis neuropeptide s receptor 0.033 0.1805 0.2582
Echinococcus granulosus roundabout 2 0.0072 0.0342 0.049
Loa Loa (eye worm) hypothetical protein 0.0057 0.0256 0.0861
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0111 0.0564 0.5429
Schistosoma mansoni hypothetical protein 0.033 0.1805 0.1805
Onchocerca volvulus 0.033 0.1805 0.6062
Echinococcus multilocularis neuropeptide receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0004 0.0012
Echinococcus multilocularis neuropeptide receptor A26 0.033 0.1805 0.2582
Echinococcus granulosus biogenic amine 5HT receptor 0.033 0.1805 0.2582
Brugia malayi Melatonin receptor type 1A 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus granulosus neuropeptide Y receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0013 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.033 0.1805 0.1805
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0111 0.0564 0.5429
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Brugia malayi Cytochrome P450 family protein 0.0189 0.1008 0.3386
Mycobacterium ulcerans hypothetical protein 0.0154 0.0807 0.7926
Schistosoma mansoni amine GPCR 0.033 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Echinococcus multilocularis neuropeptide receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0111 0.0564 0.5429
Loa Loa (eye worm) G-protein coupled receptor 0.033 0.1805 0.6062
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.033 0.1805 0.1805
Echinococcus multilocularis neuroglian 0.0065 0.0302 0.0432
Echinococcus granulosus neuropeptide s receptor 0.033 0.1805 0.2582
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0111 0.0564 0.1876
Brugia malayi RE15519p 0.033 0.1805 0.6062
Entamoeba histolytica protein kinase domain containing protein 0.0249 0.1346 0.4509
Echinococcus multilocularis G-protein coupled receptor, putative 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni cytochrome P450 0.0111 0.0564 0.0564
Trichomonas vaginalis CAMK family protein kinase 0.0536 0.2977 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0111 0.0564 0.5429
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.006 0.0273 0.0918
Echinococcus multilocularis fmrfamide receptor 0.033 0.1805 0.2582
Mycobacterium leprae Conserved hypothetical protein 0.0111 0.0564 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.033 0.1805 0.1805
Echinococcus granulosus g protein coupled receptor 0.033 0.1805 0.2582
Brugia malayi Serotonin receptor 0.033 0.1805 0.6062
Loa Loa (eye worm) CYP4Cod1 0.0189 0.1008 0.3386
Schistosoma mansoni biogenic amine (dopamine) receptor 0.033 0.1805 0.1805
Schistosoma mansoni hypothetical protein 0.033 0.1805 0.1805
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.006 0.0273 0.0391
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Loa Loa (eye worm) cytochrome P450 family protein 0.0189 0.1008 0.3386
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0111 0.0564 0.6849
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0077 0.0258
Onchocerca volvulus 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Onchocerca volvulus 0.033 0.1805 0.6062
Brugia malayi RNA binding protein 0.0061 0.0282 0.0947
Brugia malayi hypothetical protein 0.006 0.0277 0.0931
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0249 0.1346 0.4509
Trypanosoma cruzi polo-like protein kinase, putative 0.0536 0.2977 1
Echinococcus granulosus g protein coupled receptor 0.033 0.1805 0.2582
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.033 0.1805 0.6062
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.159 0.533
Trypanosoma cruzi aurora B kinase, putative 0.0249 0.1346 0.4509
Brugia malayi neuropeptide F receptor 0.033 0.1805 0.6062
Echinococcus granulosus 7TM GPCR rhodopsin 0.033 0.1805 0.2582
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0111 0.0564 0.5429
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.0931
Schistosoma mansoni cell adhesion molecule 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis Immunoglobulin 0.0056 0.0255 0.0365
Schistosoma mansoni cell adhesion molecule 0.0012 0.0004 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0022 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0111 0.0564 0.6849
Schistosoma mansoni hemicentin 0.0012 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0536 0.2977 1
Echinococcus multilocularis 0.0111 0.0564 0.0808
Echinococcus multilocularis tachykinin peptides receptor 99D 0.033 0.1805 0.2582
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0536 0.2977 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0341 0.1869 0.6277
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis twitchin 0.0014 0.0013 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0168 0.0539
Trypanosoma brucei polo-like protein kinase 0.0536 0.2977 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0189 0.1008 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus multilocularis roundabout 2 0.0072 0.0342 0.049
Echinococcus granulosus somatostatin receptor 0.033 0.1805 0.2582
Echinococcus granulosus neuroglian 0.0015 0.0022 0.0031
Schistosoma mansoni histamine h1 receptor 0.033 0.1805 0.1805
Echinococcus granulosus serotonin receptor 0.033 0.1805 0.2582
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0168 0.0539
Brugia malayi G protein-coupled receptor 0.033 0.1805 0.6062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.033 0.1805 0.2582
Loa Loa (eye worm) cytochrome P450 0.0111 0.0564 0.1896
Brugia malayi G-protein coupled receptor 0.033 0.1805 0.6062
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0038 0.0127
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0111 0.0564 0.6849
Brugia malayi Tachykinin-like peptides receptor 99D 0.033 0.1805 0.6062
Toxoplasma gondii hypothetical protein 0.0047 0.0202 0.1451
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0282 0.0282
Echinococcus multilocularis sex peptide receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0018 0.0034 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.1805 0.2582
Echinococcus granulosus tm gpcr rhodopsin 0.033 0.1805 0.2582
Loa Loa (eye worm) RNA binding protein 0.0061 0.0282 0.0947
Schistosoma mansoni protein kinase 0.0013 0.0008 0.0008
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.0022 0.0031
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Onchocerca volvulus Huntingtin homolog 0.0118 0.0606 0.2037
Brugia malayi follicle stimulating hormone receptor 0.033 0.1805 0.6062
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0056 0.0255 0.0255
Brugia malayi CXXC zinc finger family protein 0.0028 0.0092 0.031
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0034 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0186 0.0186
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0111 0.0564 0.5429
Brugia malayi AKH receptor 0.033 0.1805 0.6062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0004 0.0012
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0111 0.0564 0.5429
Schistosoma mansoni ap endonuclease 0.0018 0.0038 0.0038
Trypanosoma cruzi cytochrome P450, putative 0.0189 0.1008 0.3369
Schistosoma mansoni amine GPCR 0.033 0.1805 0.1805
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0186 0.0623
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0012 0.0004 0.0012
Onchocerca volvulus 0.033 0.1805 0.6062
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni adenoreceptor 0.033 0.1805 0.1805
Brugia malayi EGF-like domain containing protein 0.0017 0.003 0.0101
Brugia malayi hypothetical protein 0.0341 0.1869 0.6277
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.1805 0.1805
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0016 0.0024 0.0034
Echinococcus granulosus G protein coupled receptor 139 0.033 0.1805 0.2582
Echinococcus granulosus nephrin 0.0012 0.0004 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.033 0.1805 0.2582
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0016 0.0024 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.1805 0.2582
Schistosoma mansoni amine GPCR 0.033 0.1805 0.1805
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0015 0.0022 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0013 0.0013
Echinococcus multilocularis g protein coupled receptor 0.033 0.1805 0.2582
Trypanosoma brucei aurora B kinase 0.0249 0.1346 0.4509
Onchocerca volvulus 0.033 0.1805 0.6062
Brugia malayi hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni cell adhesion molecule 0.0064 0.0295 0.0295
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0111 0.0564 0.5429
Onchocerca volvulus 0.033 0.1805 0.6062
Schistosoma mansoni biogenic amine receptor 0.033 0.1805 0.1805
Entamoeba histolytica protein kinase, putative 0.0249 0.1346 0.4509
Onchocerca volvulus 0.033 0.1805 0.6062
Onchocerca volvulus 0.0017 0.0029 0.0096
Brugia malayi Immunoglobulin I-set domain containing protein 0.0122 0.0626 0.2102
Echinococcus granulosus peroxidasin 0.0012 0.0001 0.0002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) G-protein coupled receptor 0.033 0.1805 0.6062
Echinococcus multilocularis Immunoglobulin 0.0056 0.0255 0.0365
Trichomonas vaginalis AGC family protein kinase 0.0249 0.1346 0.4452
Echinococcus granulosus neuropeptides capa receptor 0.033 0.1805 0.2582
Onchocerca volvulus 0.0028 0.0092 0.031
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Schistosoma mansoni myosin xvIII 0.033 0.1805 0.1805
Schistosoma mansoni neuroglian 0.0015 0.0022 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0249 0.1346 0.4452
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.159 0.533
Echinococcus multilocularis allatostatin A receptor 0.033 0.1805 0.2582
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0056 0.0255 0.0255
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.033 0.1805 0.6062
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0015 0.0022 0.0031
Loa Loa (eye worm) hypothetical protein 0.0118 0.0606 0.2037
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0111 0.0564 0.6849
Loa Loa (eye worm) hypothetical protein 0.033 0.1805 0.6062
Loa Loa (eye worm) hypothetical protein 0.0056 0.0255 0.0857
Echinococcus multilocularis g protein coupled receptor 0.033 0.1805 0.2582
Loa Loa (eye worm) melatonin receptor type 1A 0.033 0.1805 0.6062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.033 0.1805 0.2582
Mycobacterium leprae putative cytochrome p450 0.0111 0.0564 0.5
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0111 0.0564 0.5429
Trypanosoma cruzi polo-like protein kinase, putative 0.0536 0.2977 1
Echinococcus granulosus Immunoglobulin 0.0056 0.0255 0.0365
Echinococcus granulosus twitchin 0.007 0.0333 0.0476
Echinococcus multilocularis dro:myosuppressin receptor 0.033 0.1805 0.2582

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -15 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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