Detailed information for compound 1055348

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 397.426 | Formula: C24H19N3O3
  • H donors: 3 H acceptors: 3 LogP: 2.01 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1Cn2c3ccccc3c3c2c2n(C[C@@H]1O)c1ccccc1c2c1c3CNC1=O
  • InChi: 1S/C24H19N3O3/c28-17-10-26-15-7-3-1-5-12(15)19-14-9-25-24(30)21(14)20-13-6-2-4-8-16(13)27(11-18(17)29)23(20)22(19)26/h1-8,17-18,28-29H,9-11H2,(H,25,30)/t17-,18+/m1/s1
  • InChiKey: BZSUCLDZAQTFQJ-MSOLQXFVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens spleen tyrosine kinase Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL References
Homo sapiens Janus kinase 3 Starlite/ChEMBL References
Homo sapiens signal transducer and activator of transcription 5A Starlite/ChEMBL References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Loa Loa (eye worm) STAT protein Get druggable targets OG5_131720 All targets in OG5_131720
Brugia malayi STAT protein, DNA binding domain containing protein Get druggable targets OG5_131720 All targets in OG5_131720
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RhoGAP domain containing protein 0.0079 0.0423 0.0461
Entamoeba histolytica PH domain containing protein kinase, putative 0.006 0.0224 0.1103
Schistosoma mansoni vav2 0.0085 0.048 0.0785
Giardia lamblia Kinase, CMGC CK2 0.0082 0.0447 0.2441
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0743 0.4207
Echinococcus granulosus tyrosine protein kinase shark 0.0593 0.5815 0.5815
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0053 0.0144 0.0158
Trichomonas vaginalis AGC family protein kinase 0.017 0.1372 0.7975
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0079 0.0423 0.0686
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0046 0.0069 0.0069
Giardia lamblia Kinase, CMGC CDK 0.01 0.0641 0.3597
Echinococcus multilocularis dual specificity 0.0103 0.0676 0.0826
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0061 0.0232 0.1153
Trypanosoma cruzi aurora B kinase, putative 0.0126 0.0917 0.5019
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0162 0.1294 0.1581
Plasmodium falciparum NIMA related kinase 1 0.0117 0.082 0.8899
Schistosoma mansoni protein kinase 0.0068 0.0301 0.0476
Onchocerca volvulus 0.008 0.0432 0.0788
Echinococcus multilocularis serine:threonine protein kinase 0.0056 0.0172 0.0211
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0162 0.1294 0.1581
Schistosoma mansoni serine/threonine-protein kinase 0.0089 0.052 0.0854
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0972 0.1634
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0167 0.0204
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Trypanosoma brucei rac serine-threonine kinase, putative 0.017 0.1372 0.7878
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0236 0.2068 0.2259
Schistosoma mansoni protein kinase 0.0068 0.0301 0.0476
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0108 0.072 0.0879
Leishmania major casein kinase II, putative 0.0082 0.0447 0.2441
Brugia malayi Immunoglobulin I-set domain containing protein 0.0606 0.5948 0.6498
Echinococcus multilocularis mitogen activated protein kinase 11 0.014 0.1058 0.1292
Echinococcus multilocularis Glutaredoxin protein 5 0.0068 0.03 0.0367
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0173 0.1405 0.1535
Entamoeba histolytica protein kinase domain containing protein 0.011 0.0743 0.4207
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0164 0.1316 0.1437
Giardia lamblia Kinase, AGC PKA 0.0083 0.0463 0.2537
Loa Loa (eye worm) CDC7 protein kinase 0.0071 0.034 0.0372
Echinococcus granulosus insulin receptor 0.0431 0.4115 0.4115
Echinococcus multilocularis casein kinase I alpha 0.0053 0.0144 0.0176
Echinococcus granulosus serine:threonine protein kinase 0.0056 0.0172 0.0172
Brugia malayi hypothetical protein 0.0077 0.0397 0.0433
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0167 0.0204
Schistosoma mansoni serine/threonine kinase 0.0097 0.0605 0.1
Onchocerca volvulus 0.008 0.0434 0.0791
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0069 0.0076
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.01 0.0641 0.3597
Onchocerca volvulus 0.011 0.0743 0.1394
Echinococcus granulosus casein kinase ii subunit alpha 0.0082 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.007 0.0324 0.0354
Echinococcus granulosus tyrosine protein kinase Src42A 0.0103 0.0676 0.0676
Leishmania major protein kinase, putative 0.0126 0.0917 0.5248
Trichomonas vaginalis STE family protein kinase 0.0068 0.0301 0.1569
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0173 0.1405 0.1535
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0066 0.0278 0.1428
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0066 0.0287 0.1485
Echinococcus granulosus tyrosine kinase 0.0138 0.1039 0.1039
Echinococcus multilocularis insulin receptor 0.0431 0.4115 0.5027
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.1039 0.1269
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0083 0.0463 0.2178
Plasmodium falciparum glycogen synthase kinase 3 0.011 0.0743 0.8018
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0307 0.0486
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0063 0.0255 0.0311
Onchocerca volvulus 0.012 0.0845 0.1593
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.011 0.0743 0.1238
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0046 0.0069 0.0069
Echinococcus multilocularis SH2 motif 0.0046 0.0069 0.0085
Echinococcus multilocularis casein kinase I delta 0.0053 0.0144 0.0176
Schistosoma mansoni tyrosine kinase 0.0162 0.1294 0.2191
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0075 0.0372 0.0598
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0255 0.1288
Onchocerca volvulus 0.0479 0.4613 0.8953
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0068 0.03 0.03
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0097 0.0605 0.0605
Echinococcus multilocularis casein kinase ii subunit alpha 0.0082 0.0447 0.0546
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0053 0.0145 0.0177
Trypanosoma cruzi casein kinase, putative 0.0053 0.0144 0.0178
Schistosoma mansoni tyrosine kinase 0.0352 0.3281 0.5622
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0447 0.2441
Echinococcus granulosus aurora kinase A 0.0126 0.0917 0.0917
Brugia malayi Protein kinase domain containing protein 0.0911 0.9153 1
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.0676 0.381
Loa Loa (eye worm) hypothetical protein 0.012 0.0845 0.0923
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0053 0.0144 0.0158
Brugia malayi Variant SH3 domain containing protein 0.007 0.0324 0.0354
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0173 0.1405 0.1405
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0055 0.0167 0.0319
Toxoplasma gondii casein kinase I 0.0053 0.0144 0.0823
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0097 0.0605 0.0661
Brugia malayi Protein kinase domain containing protein 0.0103 0.0676 0.0738
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0069 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0605 0.3384
Echinococcus granulosus casein kinase I delta 0.0053 0.0144 0.0144
Schistosoma mansoni tyrosine kinase 0.0591 0.5797 0.9969
Schistosoma mansoni protein kinase 0.005 0.0116 0.0155
Leishmania major protein kinase, putative 0.005 0.0116 0.0459
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0055 0.0167 0.0319
Brugia malayi Protein kinase domain containing protein 0.0176 0.1438 0.157
Schistosoma mansoni hypothetical protein 0.0046 0.0069 0.0075
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0917 0.1001
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.018 0.1475 0.1475
Entamoeba histolytica SH2-protein kinase domain containing protein 0.008 0.0432 0.2351
Giardia lamblia Kinase, STE STE20 0.0068 0.0301 0.1569
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0103 0.0676 0.3512
Loa Loa (eye worm) hypothetical protein 0.0137 0.1025 0.112
Echinococcus granulosus NCK adaptor protein 0.007 0.0324 0.0324
Echinococcus granulosus cyclin dependent kinase 5 0.01 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0077 0.0397 0.0434
Brugia malayi Sex muscle abnormal protein 5 0.007 0.0324 0.0354
Echinococcus multilocularis epidermal growth factor receptor 0.0386 0.3644 0.4451
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0046 0.0069 0.0075
Plasmodium vivax casein kinase 1, putative 0.0053 0.0144 0.1527
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0097 0.0605 0.0605
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0055 0.0167 0.1454
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1711 1
Brugia malayi Protein kinase c protein 2 0.009 0.053 0.0578
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0132 0.0972 0.1062
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.034 0.0543
Echinococcus granulosus defective proboscis extension response 0.0075 0.0372 0.0372
Echinococcus multilocularis tyrosine protein kinase HCK 0.0092 0.0559 0.0683
Trichomonas vaginalis STE family protein kinase 0.0068 0.0301 0.1569
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0097 0.0605 0.0739
Leishmania major protein kinase, putative 0.0066 0.0287 0.1485
Echinococcus granulosus Glutaredoxin protein 5 0.0068 0.03 0.03
Echinococcus multilocularis cyclin dependent kinase 0.01 0.0641 0.0783
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.0915 0.0999
Brugia malayi Protein kinase domain containing protein 0.0097 0.0605 0.066
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Trypanosoma cruzi casein kinase, putative 0.0053 0.0144 0.0178
Echinococcus granulosus mitogen activated protein kinase 11 0.014 0.1058 0.1058
Schistosoma mansoni hypothetical protein 0.0046 0.0069 0.0075
Giardia lamblia Kinase, CK1 Casein kinase 0.0053 0.0144 0.0628
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0133 0.0983 0.1074
Loa Loa (eye worm) hypothetical protein 0.008 0.0432 0.0472
Loa Loa (eye worm) hypothetical protein 0.0137 0.1025 0.112
Onchocerca volvulus 0.0303 0.2774 0.5362
Entamoeba histolytica protein kinase, putative 0.0103 0.0676 0.381
Onchocerca volvulus 0.0046 0.0069 0.0079
Entamoeba histolytica protein kinase, putative 0.0126 0.0917 0.5248
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0285 0.2577 0.3149
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0046 0.0069 0.0085
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0236 0.2067 0.2067
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.1711 1
Brugia malayi cell division control protein 2 homolog 0.01 0.0641 0.0699
Trichomonas vaginalis STE family protein kinase 0.0066 0.0287 0.1485
Brugia malayi Protein kinase domain containing protein 0.0181 0.1488 0.1625
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0066 0.0278 0.1428
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Schistosoma mansoni tyrosine kinase 0.0386 0.3644 0.625
Schistosoma mansoni shc transforming protein 0.0046 0.0069 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0533 0.0875
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0082 0.0447 0.4852
Trypanosoma cruzi cdc2-related kinase 3 0.01 0.0641 0.3289
Onchocerca volvulus 0.008 0.0432 0.0788
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0055 0.0167 0.1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.011 0.0743 0.0811
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0079 0.0423 0.0686
Schistosoma mansoni tyrosine kinase 0.0105 0.0687 0.1143
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0917 0.5248
Loa Loa (eye worm) hypothetical protein 0.0063 0.0252 0.0275
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0117 0.082 0.894
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0063 0.0255 0.0255
Giardia lamblia Kinase, STE STE20 0.0066 0.0287 0.1485
Onchocerca volvulus 0.0046 0.0069 0.0079
Echinococcus granulosus signal transduction protein lnk realted 0.0046 0.0069 0.0069
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0162 0.1294 0.1581
Onchocerca volvulus 0.0046 0.0069 0.0079
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0079 0.0423 0.0462
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0046 0.0069 0.0085
Brugia malayi Protein kinase domain containing protein 0.0056 0.0172 0.0188
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0083 0.0463 0.5028
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0055 0.0167 0.0319
Echinococcus granulosus protein kinase c iota type 0.0212 0.1816 0.1816
Echinococcus multilocularis potassium large conductance calcium activated 0.0045 0.0059 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0167 0.0243
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0917 0.1001
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0605 0.1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0039 0.0004 0.0004
Loa Loa (eye worm) AGC/PKN protein kinase 0.0097 0.0605 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0676 0.1123
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0046 0.0069 0.0085
Echinococcus multilocularis protein kinase c iota type 0.0212 0.1816 0.2219
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.072 0.1199
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0105 0.0687 0.1143
Trypanosoma cruzi casein kinase, putative 0.0053 0.0144 0.0178
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0641 0.3597
Echinococcus multilocularis calcium activated potassium channel 0.009 0.0538 0.0657
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0173 0.1405 0.1717
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0212 0.1812 0.198
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0181 0.1488 0.1626
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.034 0.1801
Loa Loa (eye worm) hypothetical protein 0.0114 0.0788 0.0861
Entamoeba histolytica protein kinase, putative 0.0063 0.0255 0.1288
Loa Loa (eye worm) hypothetical protein 0.008 0.0434 0.0474
Brugia malayi serine/threonine-protein kinase 6 0.0126 0.0917 0.1001
Loa Loa (eye worm) hypothetical protein 0.0109 0.0734 0.0802
Echinococcus granulosus SHC transforming protein 3 0.0046 0.0069 0.0069
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.013 0.0951 0.1038
Brugia malayi Protein kinase domain containing protein 0.0431 0.4115 0.4495
Schistosoma mansoni tyrosine kinase 0.0162 0.1294 0.2191
Loa Loa (eye worm) hypothetical protein 0.0093 0.0561 0.0613
Brugia malayi cytokine inducible SH2-containing protein 5 0.0046 0.0069 0.0075
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0181 0.1488 0.1488
Echinococcus multilocularis rho associated protein kinase 0.0303 0.2774 0.3389
Schistosoma mansoni serine/threonine protein kinase 0.041 0.3897 0.6688
Brugia malayi SH2 domain containing protein 0.0046 0.0069 0.0075
Brugia malayi serine/threonine-protein kinase PAK 7 0.0212 0.1812 0.1979
Trypanosoma cruzi casein kinase, putative 0.0053 0.0144 0.0178
Brugia malayi Protein kinase domain containing protein 0.0173 0.1405 0.1535
Echinococcus multilocularis tensin 0.0046 0.0069 0.0085
Plasmodium vivax protein kinase Crk2 0.01 0.0641 0.6973
Trypanosoma cruzi casein kinase, putative 0.0053 0.0144 0.0178
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.014 0.1058 0.5903
Echinococcus granulosus CDC7 cell division cycle 7 0.0071 0.034 0.034
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0162 0.1294 0.1581
Schistosoma mansoni signal transduction protein lnk-related 0.0046 0.0069 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.034 0.1801
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0434 0.414 0.414
Toxoplasma gondii AGC kinase 0.0055 0.0167 0.1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0162 0.1294 0.1581
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0917 0.5248
Echinococcus granulosus NDR protein kinase 0.0097 0.0605 0.0605
Plasmodium falciparum protein kinase, putative 0.005 0.0116 0.0874
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0083 0.0463 0.0566
Brugia malayi Protein kinase domain containing protein 0.0166 0.1337 0.146
Schistosoma mansoni vesicular amine transporter 0.0078 0.0405 0.0655
Schistosoma mansoni growth factor receptor-bound protein 0.007 0.0324 0.0516
Echinococcus granulosus cyclin dependent kinase 0.01 0.0641 0.0641
Schistosoma mansoni cell adhesion molecule 0.0095 0.0586 0.0968
Schistosoma mansoni tyrosine kinase 0.0352 0.3281 0.5622
Schistosoma mansoni tensin 0.0046 0.0069 0.0075
Entamoeba histolytica protein kinase, putative 0.0092 0.0559 0.3112
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Giardia lamblia Kinase, PLK 0.0202 0.1711 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0126 0.0917 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0173 0.1405 0.1535
Loa Loa (eye worm) variant SH3 domain-containing protein 0.007 0.0324 0.0354
Brugia malayi Protein kinase domain containing protein 0.017 0.1372 0.1499
Echinococcus granulosus suppressor of cytokine signaling 7 0.0046 0.0069 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0303 0.2774 0.4748
Entamoeba histolytica protein kinase domain containing protein 0.0126 0.0917 0.5248
Echinococcus granulosus mitogen activated protein kinase 14 0.014 0.1058 0.1058
Echinococcus granulosus raf serine:threonine protein kinase 0.0068 0.0307 0.0307
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0068 0.0301 0.0301
Brugia malayi SH2 domain containing protein 0.0046 0.0069 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0641 0.3597
Onchocerca volvulus Tyrosine kinase homolog 0.053 0.5149 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0103 0.0676 0.3512
Trichomonas vaginalis AGC family protein kinase 0.0117 0.082 0.467
Brugia malayi Temporarily assigned gene name protein 59 0.0127 0.0924 0.1009
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1711 0.2911
Echinococcus multilocularis casein kinase I delta 0.0053 0.0144 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.1488 0.2526
Onchocerca volvulus 0.0114 0.0788 0.1482
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0052 0.0139 0.0152
Toxoplasma gondii CMGC kinase, CK2 family 0.0082 0.0447 0.3197
Echinococcus granulosus tyrosine protein kinase Blk 0.0138 0.1039 0.1039
Onchocerca volvulus 0.008 0.0432 0.0788
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0046 0.0069 0.0085
Echinococcus multilocularis neuroglian 0.0091 0.0545 0.0666
Entamoeba histolytica hypothetical protein 0.0103 0.0676 0.381
Echinococcus multilocularis tyrosine protein kinase Srms 0.0138 0.1039 0.1269
Echinococcus granulosus twitchin 0.0107 0.0708 0.0708
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0243 0.2145 0.262
Trypanosoma brucei polo-like protein kinase 0.0202 0.1711 1
Brugia malayi Bm-MIF-1, identical 0.0043 0.0039 0.0042
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0043 0.0039 0.0375
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0606 0.5948 0.6498
Echinococcus multilocularis myosin iiia 0.0066 0.0287 0.0351
Loa Loa (eye worm) AGC/NDR protein kinase 0.0097 0.0605 0.0661
Brugia malayi MAP kinase sur-1 0.0066 0.0278 0.0303
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0203 0.1724 0.2106
Schistosoma mansoni protein kinase 0.0126 0.0917 0.1539
Entamoeba histolytica protein kinase 2, putative 0.0083 0.0463 0.2537
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0236 0.2067 0.2525
Brugia malayi Protein kinase domain 0.0068 0.0301 0.0329
Echinococcus granulosus tensin 0.0046 0.0069 0.0069
Echinococcus multilocularis cyclin dependent kinase 5 0.01 0.0641 0.0783
Echinococcus granulosus calcium activated potassium channel 0.009 0.0538 0.0538
Echinococcus multilocularis growth factor receptor bound protein 2 0.007 0.0324 0.0396
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0075 0.0372 0.0598
Schistosoma mansoni atypical protein kinase C 0.0218 0.1879 0.3202
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0053 0.0144 0.0176
Plasmodium vivax glycogen synthase kinase 3, putative 0.011 0.0743 0.8092
Echinococcus granulosus N chimaerin 0.0079 0.0423 0.0423
Trypanosoma brucei casein kinase I, isoform 2 0.0053 0.0144 0.0178
Loa Loa (eye worm) TK/EPH protein kinase 0.0115 0.0797 0.087
Giardia lamblia Kinase, NEK 0.0117 0.082 0.467
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0053 0.0144 0.0178
Brugia malayi SRC-1 0.0162 0.1294 0.1413
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.1382 0.2343
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0126 0.0917 0.112
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0489 0.0799
Echinococcus multilocularis Immunoglobulin 0.0075 0.0372 0.0455
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0117 0.082 0.6116
Trypanosoma cruzi cdc2-related kinase 3 0.01 0.0641 0.3289
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Brugia malayi Protein kinase domain containing protein 0.0046 0.0069 0.0074
Loa Loa (eye worm) AGC/PKA protein kinase 0.0055 0.0167 0.0182
Schistosoma mansoni protein kinase 0.0203 0.1724 0.2933
Schistosoma mansoni nck2/grb4 0.007 0.0324 0.0516
Schistosoma mansoni ste20-related kinase 0.0185 0.1533 0.2604
Schistosoma mansoni ephrin receptor 0.0098 0.0615 0.1018
Brugia malayi SH2 domain containing protein 0.008 0.0432 0.0471
Brugia malayi Protein kinase domain containing protein 0.008 0.0432 0.0471
Echinococcus multilocularis SH2 motif 0.0046 0.0069 0.0085
Loa Loa (eye worm) TK protein kinase 0.0246 0.2176 0.2378
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0053 0.0145 0.0145
Trichomonas vaginalis AGC family protein kinase 0.017 0.1372 0.7975
Loa Loa (eye worm) hypothetical protein 0.0052 0.0139 0.0151
Schistosoma mansoni tensin 0.0046 0.0069 0.0075
Entamoeba histolytica cell division protein kinase 2, putative 0.01 0.0641 0.3597
Schistosoma mansoni tyrosine kinase 0.0066 0.0277 0.0434
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0068 0.0301 0.0368
Brugia malayi STAT protein, DNA binding domain containing protein 0.0384 0.3623 0.3958
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0145 0.0205
Echinococcus granulosus tyrosine protein kinase ABL1 0.0285 0.2577 0.2577
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0278 0.1428
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.011 0.0743 0.0907
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.011 0.0743 0.4207
Echinococcus granulosus protein kinase C gamma type 0.0137 0.1028 0.1028
Echinococcus multilocularis casein kinase I alpha 0.0053 0.0144 0.0176
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0055 0.0167 0.0319
Trichomonas vaginalis CK1 family protein kinase 0.0053 0.0144 0.0628
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.041 0.3897 0.4258
Plasmodium falciparum casein kinase 2, alpha subunit 0.0082 0.0447 0.4651
Schistosoma mansoni adapter molecule crk 0.007 0.0324 0.0516
Brugia malayi SH2 domain containing protein 0.0046 0.0069 0.0075
Brugia malayi Protein kinase domain containing protein 0.008 0.0432 0.0471
Echinococcus granulosus epidermal growth factor receptor 0.0591 0.5797 0.5797
Entamoeba histolytica p21-activated kinase 0.0073 0.0358 0.1909
Echinococcus granulosus protein kinase shaggy 0.011 0.0743 0.0743
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Loa Loa (eye worm) hypothetical protein 0.008 0.0434 0.0474
Brugia malayi Protein kinase domain containing protein 0.01 0.0641 0.0699
Echinococcus granulosus neuroglian 0.0091 0.0545 0.0545
Onchocerca volvulus 0.008 0.0432 0.0788
Onchocerca volvulus 0.0071 0.034 0.0608
Echinococcus multilocularis ephrin type A receptor 4 A 0.0098 0.0615 0.0751
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0917 0.1539
Echinococcus multilocularis serine:threonine protein kinase 38 0.0097 0.0605 0.0739
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0046 0.0069 0.0069
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0046 0.0069 0.0085
Trichomonas vaginalis STE family protein kinase 0.0068 0.0301 0.1569
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0086 0.0489 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0605 0.1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.01 0.0641 0.07
Brugia malayi SH2 domain containing protein 0.0046 0.0069 0.0075
Schistosoma mansoni tyrosine kinase 0.0593 0.5815 1
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Echinococcus multilocularis mitogen activated protein kinase 11 0.014 0.1058 0.1292
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.072 0.1199
Brugia malayi casein kinase 1, delta 0.0053 0.0144 0.0157
Onchocerca volvulus 0.0071 0.034 0.0608
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0086 0.0489 0.0489
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0046 0.0069 0.0079
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0103 0.0676 0.0825
Schistosoma mansoni tensin-related 0.0046 0.0069 0.0075
Echinococcus multilocularis tensin 0.0046 0.0069 0.0085
Echinococcus granulosus suppressor of cytokine signaling 6 0.0046 0.0069 0.0069
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0066 0.0287 0.1485
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Echinococcus multilocularis aurora kinase A 0.0126 0.0917 0.112
Echinococcus granulosus cyclin dependent kinase 1 0.01 0.0641 0.0641
Giardia lamblia Kinase, AGC PKA 0.0055 0.0167 0.0763
Brugia malayi Fibronectin type III domain containing protein 0.0077 0.0397 0.0433
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0917 0.5248
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0167 0.0167
Echinococcus granulosus SH2 domain containing adapter protein F 0.0046 0.0069 0.0069
Loa Loa (eye worm) AGC/PKA protein kinase 0.0055 0.0167 0.0182
Echinococcus multilocularis serine:threonine protein kinase N2 0.0097 0.0605 0.0739
Echinococcus granulosus protein kinase c epsilon type 0.0132 0.0972 0.0972
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0104 0.068 0.383
Loa Loa (eye worm) hypothetical protein 0.0088 0.0513 0.0561
Entamoeba histolytica PH domain containing protein kinase, putative 0.006 0.0224 0.1103
Leishmania major casein kinase, putative 0.0053 0.0144 0.0628
Trypanosoma brucei Casein kinase II 0.0082 0.0447 0.2077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0397 0.0433
Echinococcus granulosus tyrosine protein kinase HCK 0.0092 0.0559 0.0559
Entamoeba histolytica cell division protein kinase 2, putative 0.01 0.0641 0.3597
Brugia malayi Furin-like cysteine rich region family protein 0.0591 0.5797 0.6332
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0255 0.0395
Loa Loa (eye worm) hypothetical protein 0.0233 0.204 0.2229
Entamoeba histolytica protein kinase, putative 0.017 0.1372 0.7975
Brugia malayi Tyrosine-protein kinase abl-1 0.0183 0.1508 0.1646
Echinococcus granulosus tyrosine kinase 0.008 0.0432 0.0432
Entamoeba histolytica protein kinase, putative 0.0053 0.0145 0.063
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0046 0.0069 0.0076
Entamoeba histolytica protein kinase, putative 0.017 0.1372 0.7975
Loa Loa (eye worm) hypothetical protein 0.0051 0.0126 0.0138
Echinococcus multilocularis tyrosine kinase 0.008 0.0432 0.0528
Schistosoma mansoni SH2A 0.0046 0.0069 0.0075
Brugia malayi intracellular kinase 0.011 0.0743 0.0811
Brugia malayi Immunoglobulin I-set domain containing protein 0.0246 0.2176 0.2377
Plasmodium vivax unspecified product 0.0082 0.0447 0.4852
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0093 0.0561 0.0561
Loa Loa (eye worm) SH2 domain-containing protein 0.0046 0.0069 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0605 0.3384
Echinococcus granulosus SH2 motif 0.0046 0.0069 0.0069
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0042 0.0026 0.0028
Echinococcus multilocularis death associated protein kinase 1 0.0819 0.8186 1
Brugia malayi phosphoinositide-dependent protein kinase I 0.0063 0.0255 0.0277
Schistosoma mansoni GTPase activating protein 0.0046 0.0069 0.0075
Giardia lamblia Kinase, CMGC GSK 0.011 0.0743 0.4207
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0278 0.1428
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0043 0.0039 0.0043
Schistosoma mansoni tyrosine kinase 0.0239 0.2098 0.358
Onchocerca volvulus 0.0053 0.0144 0.0225
Echinococcus granulosus tyrosine protein kinase Srms 0.008 0.0432 0.0432
Echinococcus granulosus hypothetical protein 0.0046 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0117 0.082 0.0896
Brugia malayi STE20-like kinase MST 0.0236 0.2068 0.2259
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.011 0.0743 0.3929
Brugia malayi Protein kinase domain containing protein 0.0071 0.034 0.0371
Loa Loa (eye worm) STAT protein 0.0384 0.3623 0.3959
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.014 0.1058 0.5903
Giardia lamblia Kinase, CDC7 0.0071 0.034 0.1801
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0069 0.0177
Echinococcus granulosus tyrosine protein kinase Fps85D 0.008 0.0432 0.0432
Schistosoma mansoni calcium-activated potassium channel 0.0045 0.0059 0.0057
Onchocerca volvulus 0.0288 0.2612 0.5044
Loa Loa (eye worm) CMGC/GSK protein kinase 0.011 0.0743 0.0811
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0983 0.1654
Entamoeba histolytica protein kinase, putative 0.0046 0.0077 0.0227
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0202 0.1711 0.1711
Echinococcus granulosus ephrin type A receptor 4 A 0.0098 0.0615 0.0615
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.014 0.1058 0.6091
Trichomonas vaginalis AGC family protein kinase 0.017 0.1372 0.7975
Entamoeba histolytica protein kinase, putative 0.0164 0.1316 0.7635
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Schistosoma mansoni protein kinase 0.0203 0.1724 0.2933
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0162 0.1294 0.1581
Echinococcus granulosus nervana 2 0.0068 0.03 0.03
Echinococcus multilocularis casein kinase I alpha 0.0053 0.0144 0.0176
Trichomonas vaginalis STE family protein kinase 0.0117 0.082 0.467
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0272 0.2441 0.2666
Schistosoma mansoni tensin 0.0046 0.0069 0.0075
Entamoeba histolytica protein kinase, putative 0.0061 0.0232 0.1153
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0447 0.2441
Giardia lamblia Kinase, CMGC GSK 0.011 0.0743 0.4207
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0605 0.3384
Schistosoma mansoni tyrosine kinase 0.0431 0.4115 0.7064
Schistosoma mansoni growth factor receptor-bound protein 0.007 0.0324 0.0516
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0055 0.0167 0.0181
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0162 0.1294 0.1581
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0066 0.0287 0.1075
Trypanosoma brucei protein kinase, putative 0.011 0.0743 0.3929
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0133 0.0983 0.1073
Brugia malayi p70 ribosomal S6 kinase beta 0.0164 0.1316 0.1437
Plasmodium falciparum casein kinase 1 0.0053 0.0144 0.1197
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0126 0.0917 0.5248
Schistosoma mansoni kinase 0.011 0.0745 0.1242
Echinococcus granulosus casein kinase I delta 0.0053 0.0144 0.0144
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0068 0.0301 0.0368
Brugia malayi protein kinase C II. 0.0132 0.0972 0.1061
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1711 1
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1711 1
Brugia malayi Stress-activated protein kinase jnk-1 0.0243 0.2145 0.2343
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0172 0.0797
Echinococcus multilocularis NCK adaptor protein 0.007 0.0324 0.0396
Echinococcus granulosus Protein kinase C brain isozyme 0.0171 0.1382 0.1382
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.2145 0.3661
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0162 0.1294 0.1294
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0075 0.0372 0.0455
Echinococcus granulosus fibroblast growth factor receptor 4 0.023 0.2003 0.2003
Brugia malayi Tensin 0.0046 0.0069 0.0075
Echinococcus granulosus MAP kinase activated protein kinase 2 0.041 0.3897 0.3897
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0278 0.0435
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0055 0.0167 0.0319
Trypanosoma brucei protein kinase, putative 0.0066 0.0278 0.1016
Loa Loa (eye worm) hypothetical protein 0.0073 0.0354 0.0387
Loa Loa (eye worm) AGC/AKT protein kinase 0.017 0.1372 0.1499
Echinococcus granulosus myotubularin protein 13 0.0039 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.017 0.1379 0.1507
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Loa Loa (eye worm) hypothetical protein 0.0088 0.0513 0.0561
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0055 0.0167 0.0319
Echinococcus granulosus casein kinase I alpha 0.0053 0.0144 0.0144
Brugia malayi serine/threonine protein kinase 6 0.0126 0.0917 0.1001
Brugia malayi Protein kinase domain containing protein 0.0097 0.0605 0.066
Echinococcus granulosus c-Jun N-terminal kinases 0.0243 0.2145 0.2145
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0255 0.1288
Loa Loa (eye worm) sex muscle abnormal protein 5 0.007 0.0324 0.0354
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0447 0.2441
Echinococcus multilocularis protein kinase shaggy 0.011 0.0743 0.0907
Echinococcus multilocularis 0.0046 0.0069 0.0085
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0126 0.0138
Brugia malayi ephrin receptor 1 precursor 0.0064 0.0265 0.0289
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.023 0.2003 0.2447
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0069 0.0074
Echinococcus multilocularis CDC7 cell division cycle 7 0.0071 0.034 0.0416
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.052 0.2877
Echinococcus granulosus SH2 motif 0.0046 0.0069 0.0069
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0053 0.0144 0.0158
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0051 0.0126 0.0154
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0052 0.014 0.0153
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0126 0.0917 0.5248
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0043 0.0039 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0489 0.0799
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0126 0.0917 0.5248
Echinococcus multilocularis protein kinase c epsilon type 0.0132 0.0972 0.1188
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0079 0.0423 0.0517
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0743 0.4207
Echinococcus multilocularis cyclin dependent kinase 1 0.01 0.0641 0.0783
Echinococcus granulosus roundabout 2 0.0111 0.0759 0.0759
Brugia malayi hypothetical protein 0.008 0.0432 0.0471
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0063 0.0255 0.0278
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.041 0.3897 0.4761
Echinococcus granulosus tyrosine protein kinase Fyn 0.0162 0.1294 0.1294
Echinococcus multilocularis N chimaerin 0.0079 0.0423 0.0517
Echinococcus granulosus tyrosine protein kinase Fyn 0.0162 0.1294 0.1294
Loa Loa (eye worm) hypothetical protein 0.0075 0.0374 0.0409
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0162 0.1294 0.1581
Loa Loa (eye worm) TK protein kinase 0.0092 0.0559 0.0611
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0138 0.1039 0.1039
Trichomonas vaginalis STE family protein kinase 0.0068 0.0301 0.1569
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0386 0.3644 0.3644
Loa Loa (eye worm) SH2 domain-containing protein 0.0046 0.0069 0.0076
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0046 0.0069 0.0085
Echinococcus granulosus glycogen synthase kinase 3 beta 0.011 0.0743 0.0743
Loa Loa (eye worm) CAMK/PKD protein kinase 0.013 0.0951 0.1039
Echinococcus granulosus epidermal growth factor receptor 0.0386 0.3644 0.3644
Schistosoma mansoni tyrosine kinase 0.0386 0.3644 0.625
Brugia malayi C1-like domain containing protein 0.013 0.0951 0.1038
Giardia lamblia Aurora kinase 0.0126 0.0917 0.5248
Echinococcus granulosus calcium activated potassium channel variant 0.0042 0.0026 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Onchocerca volvulus 0.0046 0.0069 0.0079
Loa Loa (eye worm) TK/EGFR protein kinase 0.0591 0.5797 0.6333
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0066 0.0278 0.1016
Onchocerca volvulus 0.008 0.0432 0.0788
Leishmania major protein kinase A catalytic subunit isoform 2 0.0055 0.0167 0.0763
Loa Loa (eye worm) TK protein kinase 0.0138 0.1039 0.1135
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.018 0.1475 0.1802
Entamoeba histolytica protein kinase, putative 0.0052 0.0134 0.0567
Brugia malayi Variant SH3 domain containing protein 0.007 0.0324 0.0354
Schistosoma mansoni tyrosine kinase 0.0212 0.1812 0.3085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0069 0.0075
Entamoeba histolytica SH2 domain containing protein 0.0046 0.0069 0.0179
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0068 0.03 0.0367
Schistosoma mansoni tyrosine kinase 0.023 0.2003 0.3416
Plasmodium falciparum protein kinase 5 0.01 0.0641 0.6855
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0719 0.4066
Onchocerca volvulus Serine\/threonine kinase homolog 0.0202 0.1711 0.3285
Echinococcus multilocularis nervana 2 0.0068 0.03 0.0367
Echinococcus multilocularis serine threonine protein kinase 0.0137 0.1028 0.1256
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0144 0.0204
Brugia malayi Protein kinase domain containing protein 0.0063 0.0255 0.0277
Schistosoma mansoni tyrosine kinase 0.0431 0.4115 0.7064
Echinococcus multilocularis signal transduction protein lnk realted 0.0046 0.0069 0.0085
Brugia malayi protein-tyrosine kinase 0.0138 0.1039 0.1134
Trypanosoma cruzi casein kinase II, putative 0.0082 0.0447 0.2077
Trypanosoma cruzi cdc2-related kinase 1 0.01 0.0641 0.3289
Schistosoma mansoni tensin-related 0.0046 0.0069 0.0075
Loa Loa (eye worm) hypothetical protein 0.0077 0.0397 0.0434
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0641 0.3597
Schistosoma mansoni suppressor of cytokine signaling 0.0046 0.0069 0.0075
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.01 0.0641 0.3597
Trypanosoma cruzi cdc2-related kinase 1 0.01 0.0641 0.3289
Leishmania major protein kinase A catalytic subunit 0.0055 0.0167 0.0763
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0046 0.0069 0.0079
Toxoplasma gondii AGC kinase 0.0164 0.1316 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0202 0.1711 1
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0917 0.1001
Echinococcus multilocularis 0.0171 0.1386 0.1693
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0066 0.0278 0.187
Giardia lamblia Kinase, NEK 0.0117 0.082 0.467
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0171 0.1382 0.1688
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0203 0.1724 0.1724
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Echinococcus granulosus nervana 2 0.0068 0.03 0.03
Echinococcus multilocularis mitogen activated protein kinase 0.0066 0.0278 0.0339
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0079 0.0423 0.0423
Entamoeba histolytica protein kinase, putative 0.0053 0.0145 0.063
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0046 0.0069 0.0085
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.014 0.1058 0.1155
Echinococcus multilocularis raf serine:threonine protein kinase 0.0068 0.0307 0.0375
Echinococcus multilocularis SH2 domain containing protein 7 0.0046 0.0069 0.0085
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0167 0.0167
Echinococcus multilocularis roundabout 2 0.0111 0.0759 0.0928
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0066 0.0278 0.1016
Entamoeba histolytica protein kinase, putative 0.0068 0.0301 0.1569
Entamoeba histolytica protein kinase, putative 0.0103 0.0676 0.381
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0167 0.0763
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0202 0.1711 0.209
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0605 0.1
Echinococcus multilocularis myotubularin protein 13 0.0039 0.0001 0.0001
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0086 0.0489 0.0489
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0278 0.1016
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0255 0.1288
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0641 0.1062
Echinococcus multilocularis rac serine:threonine kinase 0.0089 0.052 0.0636
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0173 0.1405 0.2688
Onchocerca volvulus 0.008 0.0432 0.0788
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0051 0.0126 0.0126
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.052 0.2877
Echinococcus granulosus serine:threonine protein kinase N2 0.0097 0.0605 0.0605
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0046 0.0069 0.0075
Schistosoma mansoni suppressor of cytokine signaling 0.0046 0.0069 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0167 0.0243
Trichomonas vaginalis AGC family protein kinase 0.017 0.1372 0.7975
Entamoeba histolytica protein kinase domain containing protein 0.0082 0.0447 0.2441
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0039 0.0004 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0432 0.0472
Loa Loa (eye worm) hypothetical protein 0.0075 0.0372 0.0406
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0167 0.0167
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0447 0.2441
Echinococcus multilocularis c src tyrosine kinase 0.0105 0.0687 0.084
Brugia malayi serine/threonine kinase 12 0.0126 0.0917 0.1001
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0202 0.1711 0.1869
Loa Loa (eye worm) hypothetical protein 0.0055 0.0167 0.0182
Loa Loa (eye worm) SH2 domain-containing protein 0.0046 0.0069 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0641 0.1062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0001 0.0001
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0068 0.0301 0.0301
Echinococcus granulosus c src tyrosine kinase 0.0105 0.0687 0.0687
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.023 0.2003 0.2003
Schistosoma mansoni nephrin 0.0093 0.057 0.094
Schistosoma mansoni protein kinase 0.0053 0.0144 0.0204
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0083 0.0463 0.4834
Schistosoma mansoni tyrosine kinase 0.0352 0.3281 0.5622
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0278 0.1428
Brugia malayi Hr1 repeat family protein 0.0097 0.0605 0.066
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1711 1
Echinococcus granulosus casein kinase I alpha 0.0053 0.0144 0.0144
Giardia lamblia Kinase, AGC AKT 0.0098 0.0623 0.349
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0139 0.0594
Echinococcus multilocularis nervana 2 0.0068 0.03 0.0367
Trichomonas vaginalis CK1 family protein kinase 0.0053 0.0144 0.0628
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0056 0.0172 0.0188
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0081 0.0442 0.241
Echinococcus granulosus serine:threonine protein kinase 0.0056 0.0172 0.0172
Echinococcus granulosus expressed conserved protein 0.0046 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0085 0.0478 0.0522
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0043 0.0039 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0102 0.0662 0.3725
Brugia malayi Variant SH3 domain containing protein 0.0052 0.0139 0.0151
Entamoeba histolytica casein kinase, putative 0.0082 0.0447 0.2441
Echinococcus granulosus SH2 domain containing protein 7 0.0046 0.0069 0.0069
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0068 0.0301 0.0301
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0167 0.0204
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0055 0.0167 0.0319
Echinococcus granulosus serine threonine protein kinase nrc 0.0083 0.0463 0.0463
Loa Loa (eye worm) SRC-1 0.0162 0.1294 0.1414
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0137 0.1027 0.1122
Onchocerca volvulus 0.0046 0.0069 0.0079
Trichomonas vaginalis CK1 family protein kinase 0.0053 0.0144 0.0628
Echinococcus multilocularis tyrosine protein kinase shark 0.0593 0.5815 0.7103
Trichomonas vaginalis AGC family protein kinase 0.017 0.1372 0.7975
Echinococcus multilocularis serine:threonine protein kinase 3 0.0236 0.2068 0.2526
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0103 0.0676 0.0739
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0046 0.0069 0.0069
Brugia malayi casein kinase I 0.0053 0.0144 0.0157
Echinococcus granulosus tyrosine protein kinase Lyn 0.0178 0.1457 0.1457
Entamoeba histolytica serine/threonine protein kinase, putative 0.0202 0.1711 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0046 0.0069 0.0075
Echinococcus granulosus serine/threonine protein kinase 0.0089 0.052 0.052
Echinococcus granulosus tyrosine protein kinase Src42A 0.0162 0.1294 0.1294
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0126 0.0917 0.0917
Loa Loa (eye worm) TK/ABL protein kinase 0.0285 0.2577 0.2816
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0181 0.1488 0.1818
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.007 0.0324 0.0516
Brugia malayi map kinase activated protein kinase protein 2 0.041 0.3897 0.4257
Echinococcus multilocularis SHC transforming protein 3 0.0046 0.0069 0.0085
Echinococcus granulosus activin receptor type 0.005 0.0116 0.0116
Echinococcus granulosus rho-associated protein kinase 1 0.0303 0.2774 0.2774
Schistosoma mansoni serine/threonine protein kinase 0.018 0.1475 0.2503
Trichomonas vaginalis AGC family protein kinase 0.017 0.1372 0.7975
Toxoplasma gondii aurora kinase 0.0126 0.0917 0.6873
Brugia malayi protein kinase C3,putative 0.0131 0.0964 0.1053
Entamoeba histolytica protein kinase domain containing protein 0.011 0.0743 0.4207
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0447 0.2441
Entamoeba histolytica casein kinase 1, putative 0.0053 0.0144 0.0628
Loa Loa (eye worm) hypothetical protein 0.0077 0.0397 0.0434
Brugia malayi serine/threonine-protein kinase plk-2 0.0202 0.1711 0.1869
Echinococcus granulosus potassium large conductance calcium activated 0.0045 0.0059 0.0059
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0055 0.0167 0.1775
Leishmania major protein kinase A catalytic subunit isoform 1 0.0055 0.0167 0.0763
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0089 0.052 0.2535
Schistosoma mansoni tyrosine kinase 0.0069 0.0315 0.05
Echinococcus granulosus casein kinase I alpha 0.0053 0.0144 0.0144
Onchocerca volvulus 0.0137 0.1025 0.1946
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0053 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0075 0.0372 0.0406
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.005 0.0116 0.0601
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0066 0.0287 0.1075
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.01 0.0641 0.07
Brugia malayi Variant SH3 domain containing protein 0.0079 0.0423 0.0461
Entamoeba histolytica casein kinase, putative 0.0053 0.0144 0.0628
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0069 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0917 0.5248
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.1711 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0773 0.0845
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0243 0.2145 0.2343
Echinococcus multilocularis activin receptor type 0.005 0.0116 0.0142
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0046 0.0069 0.0075
Giardia lamblia Kinase, CMGC MAPK 0.0066 0.0278 0.1428
Entamoeba histolytica protein kinase, putative 0.011 0.0743 0.4207
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0056 0.0176 0.0192
Echinococcus multilocularis serine:threonine protein kinase N2 0.0097 0.0605 0.0739
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Echinococcus multilocularis mitogen activated protein kinase 3 0.0066 0.0278 0.0339
Loa Loa (eye worm) TK/INSR protein kinase 0.0431 0.4115 0.4496
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0063 0.0255 0.0278
Echinococcus granulosus mitogen activated protein kinase 0.0066 0.0278 0.0278
Entamoeba histolytica protein kinase , putative 0.0126 0.0917 0.5248
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0082 0.0447 0.0489
Echinococcus multilocularis casein kinase i 0.0053 0.0144 0.0176
Echinococcus multilocularis tyrosine protein kinase Blk 0.0138 0.1039 0.1269
Brugia malayi Protein kinase domain containing protein 0.008 0.0432 0.0471
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0097 0.0605 0.0739
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.01 0.0641 0.4712
Schistosoma mansoni tyrosine kinase 0.0547 0.5335 0.9172
Trichomonas vaginalis AGC family protein kinase 0.017 0.1372 0.7975
Echinococcus multilocularis mitogen activated protein kinase 14 0.014 0.1058 0.1292
Echinococcus granulosus growth factor receptor bound protein 2 0.007 0.0324 0.0324
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0278 0.1016
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1711 1
Brugia malayi SH2 domain containing protein 0.0046 0.0069 0.0075
Echinococcus multilocularis cyclin dependent kinase 1 0.01 0.0641 0.0783
Loa Loa (eye worm) hypothetical protein 0.0141 0.1075 0.1174
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Echinococcus granulosus Immunoglobulin 0.0075 0.0372 0.0372
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0096 0.0597 0.0652
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0447 0.2441
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1711 1
Schistosoma mansoni protein kinase 0.0082 0.0447 0.0728
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0066 0.0287 0.1075
Giardia lamblia Kinase, CMGC CDK 0.01 0.0641 0.3597
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0434 0.414 0.5058
Entamoeba histolytica protein kinase, putative 0.0126 0.0917 0.5248
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0167 0.0204
Entamoeba histolytica protein kinase, putative 0.0097 0.0605 0.3384
Schistosoma mansoni protein kinase C mu 0.013 0.0951 0.1598
Trichomonas vaginalis STE family protein kinase 0.0046 0.0077 0.0227
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0086 0.0489 0.0597
Schistosoma mansoni tyrosine kinase 0.0105 0.0687 0.1143
Echinococcus multilocularis mitogen activated protein kinase 14 0.014 0.1058 0.1292
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0098 0.0623 0.0679
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.1405 0.2383
Echinococcus granulosus tyrosine protein kinase Src64B 0.0162 0.1294 0.1294
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.1382 0.2343
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0116 0.0459
Brugia malayi hypothetical protein 0.0046 0.0069 0.0075
Echinococcus multilocularis Immunoglobulin 0.0075 0.0372 0.0455
Brugia malayi SH2 domain containing protein 0.0046 0.0069 0.0075
Echinococcus multilocularis epidermal growth factor receptor 0.0591 0.5797 0.7081
Echinococcus multilocularis calcium activated potassium channel variant 0.0042 0.0026 0.0032
Echinococcus multilocularis serine:threonine protein kinase 0.0056 0.0172 0.0211
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.01 0.0641 0.0641
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0066 0.0278 0.1016
Loa Loa (eye worm) hypothetical protein 0.0109 0.0734 0.0802
Echinococcus multilocularis tyrosine protein kinase Abl 0.0183 0.1508 0.1842
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0278 0.1428
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0133 0.0983 0.0983
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0133 0.0983 0.1201
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1711 1
Onchocerca volvulus 0.0046 0.0069 0.0079
Echinococcus granulosus mitogen activated protein kinase 3 0.0066 0.0278 0.0278
Echinococcus multilocularis fibroblast growth factor receptor 4 0.023 0.2003 0.2447
Loa Loa (eye worm) hypothetical protein 0.0137 0.1025 0.112
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.008 0.0432 0.0528
Trypanosoma brucei cdc2-related kinase 1 0.01 0.0641 0.3289
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0068 0.0301 0.0368
Onchocerca volvulus 0.0063 0.0252 0.0436
Echinococcus granulosus tyrosine protein kinase Fyn 0.0162 0.1294 0.1294
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0167 0.0243
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0108 0.072 0.072
Brugia malayi Protein kinase domain containing protein 0.008 0.0432 0.0471
Echinococcus granulosus casein kinase i 0.0053 0.0144 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0447 0.2441
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.018 0.1475 0.1611
Brugia malayi SH2 domain containing protein 0.008 0.0432 0.0471
Trypanosoma brucei aurora B kinase 0.0126 0.0917 0.5019
Echinococcus multilocularis PAK box P21 Rho binding 0.0046 0.0077 0.0094
Trypanosoma cruzi Protein kinase B 0.0089 0.052 0.2535
Schistosoma mansoni protein kinase 0.0046 0.0077 0.0089
Echinococcus multilocularis SH2 motif 0.0046 0.0069 0.0085
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0126 0.0917 1
Brugia malayi Casein kinase II, alpha chain 0.0082 0.0447 0.0488
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.01 0.0641 0.07
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.014 0.1058 0.5903
Schistosoma mansoni serine/threonine kinase 0.0046 0.0069 0.0074
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0103 0.0676 0.381
Brugia malayi Protein kinase domain containing protein 0.008 0.0432 0.0471
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0103 0.0676 0.3512
Giardia lamblia Kinase, NEK 0.0117 0.082 0.467
Echinococcus granulosus dual specificity 0.0103 0.0676 0.0676
Entamoeba histolytica protein kinase, putative 0.0052 0.0134 0.0567
Trypanosoma brucei cdc2-related kinase 3 0.01 0.0641 0.3289
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0083 0.0463 0.0463
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0911 0.9153 1
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0719 0.4066
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.011 0.0743 0.5511
Toxoplasma gondii AGC kinase 0.0055 0.0167 0.1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0162 0.1294 0.1294
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0066 0.0278 0.0304
Schistosoma mansoni serine/threonine-protein kinase 0.0089 0.052 0.0854
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0162 0.1294 0.1581
Brugia malayi SH2 domain containing protein 0.0046 0.0069 0.0075
Echinococcus granulosus serine:threonine protein kinase 3 0.0236 0.2068 0.2068
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.034 0.1801
Loa Loa (eye worm) hypothetical protein 0.0056 0.0172 0.0188
Brugia malayi P38 map kinase family protein 2 0.014 0.1058 0.1155

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 15 % Inhibition of ovalbumin-induced IgE production in mouse at 10 mg/kg, ip administered on day 1, 3 and 5 after 1 hr of ovalbumin challenge followed by additional dosing on day 2 and 4 measured on day 8 by ELISA ChEMBL. 19427203
Activity (functional) = 54 % Antiinflammatory activity against ovalbumin-induced asthma in BALB/c mouse model assessed as reduction of eosinophil count in broncheovular lavage fluid at 30 mg/kg, ip measured on day 32 after ovalbumin challenge ChEMBL. 19427203
Activity (functional) = 54 % Antiinflammatory activity against ovalbumin-induced asthma in BALB/c mouse model assessed as reduction of neutrophil count in broncheovular lavage fluid at 30 mg/kg, ip measured on day 32 after ovalbumin challenge ChEMBL. 19427203
Activity (functional) = 70 % Inhibition of ovalbumin-induced IgE production in mouse at 30 mg/kg, ip administered on day 1, 3 and 5 after 1 hr of ovalbumin challenge followed by additional dosing on day 2 and 4 measured on day 8 by ELISA ChEMBL. 19427203
Activity (functional) = 90 % Antiinflammatory activity against ovalbumin-induced asthma in BALB/c mouse model assessed as reduction in methacoline-induced airway constriction at 30 mg/kg, ip measured on day 32 after ovalbumin challenge ChEMBL. 19427203
IC50 (binding) = 6 nM Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylation ChEMBL. 19427203
IC50 (functional) = 98 nM Antiproliferative activity against JAK3 expressing IL2-stimulated human Jurkat cells ChEMBL. 19427203
IC50 (binding) = 200 nM Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylation ChEMBL. 19427203
IC50 (binding) = 300 nM Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylation ChEMBL. 19427203
IC50 (binding) = 689 nM Inhibition of STAT5 phosphorylation in IL2-stimulated healthy human T cells by Western blotting ChEMBL. 19427203
IC50 (binding) > 1000 nM Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylation ChEMBL. 19427203
IC50 (binding) > 1000 nM Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylation ChEMBL. 19427203
IC50 (functional) = 10000 nM Antiproliferative activity against JAK3 expressing human resting Jurkat cells ChEMBL. 19427203

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19427203

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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