Detailed information for compound 1058726

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.377 | Formula: C23H15F4N3O3
  • H donors: 1 H acceptors: 3 LogP: 3.33 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2ccccc2C2=C1C(c1c(N2)n(C)c(=O)n(c1=O)C)c1cccc(c1F)C(F)(F)F
  • InChi: 1S/C23H15F4N3O3/c1-29-20-16(21(32)30(2)22(29)33)14(12-8-5-9-13(17(12)24)23(25,26)27)15-18(28-20)10-6-3-4-7-11(10)19(15)31/h3-9,14,28H,1-2H3
  • InChiKey: BXMWHKTTYHTCOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glucosidase, putative 0.004 0.002 0.0073
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0958
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0006 0.0023
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0077 0.0282
Echinococcus granulosus microtubule associated protein 2 0.0768 0.0652 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.004 0.1035
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.0142 0.3707
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0002 0.0039
Leishmania major hypothetical protein, conserved 0.0017 0 0.0001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0002 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0511
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0031 0.0476
Plasmodium vivax SET domain protein, putative 0.0033 0.0014 0.0048
Brugia malayi mbt repeat family protein 0.0053 0.0031 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0031 0.1153
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.0077 0.1985
Onchocerca volvulus 0.0135 0.0103 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0021 0.0075
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0141
Brugia malayi mbt repeat family protein 0.0053 0.0031 0.004
Schistosoma mansoni patched 1 0.0044 0.0023 0.0351
Echinococcus granulosus single minded 2 0.0047 0.0025 0.0364
Loa Loa (eye worm) MBCTL1 0.006 0.0038 0.0958
Onchocerca volvulus 0.0041 0.0021 0.0014
Onchocerca volvulus 0.0041 0.0021 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0021 0.0965
Brugia malayi PHD-finger family protein 0.0028 0.001 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0572
Loa Loa (eye worm) hypothetical protein 0.0458 0.0383 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0031 0.0451
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0021 0.0287
Schistosoma mansoni kinase 0.0054 0.0032 0.0487
Giardia lamblia Kinase, PLK 0.0106 0.0077 0.0273
Brugia malayi hypothetical protein 0.0064 0.004 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Brugia malayi hypothetical protein 0.0072 0.0048 0.0062
Loa Loa (eye worm) hypothetical protein 0.012 0.0089 0.2301
Brugia malayi hypothetical protein 0.0064 0.004 0.0052
Trichomonas vaginalis esterase, putative 0.0041 0.0021 0.0738
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0031 0.0444
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0142 0.2164
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0002 0.0009
Echinococcus multilocularis dna polymerase eta 0.002 0.0002 0.0009
Schistosoma mansoni alpha-glucosidase 0.0156 0.0121 0.1848
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0006 0.0479
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0005 0.0018
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0511
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0006 0.0162
Mycobacterium tuberculosis Conserved protein 0.0041 0.0021 0.0965
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0014 0.0186
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0002 0.0037
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0007 0.0083
Mycobacterium ulcerans hypothetical protein 0.0041 0.0021 0.1737
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.002 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Trichomonas vaginalis set domain proteins, putative 0.0264 0.0214 0.8632
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.002 0.0498
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.3153 0.2721 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0002 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.003 0.0756
Echinococcus granulosus expressed conserved protein 0.0096 0.0068 0.1019
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0002 0.0026
Brugia malayi Protein kinase domain containing protein 0.0428 0.0357 0.0488
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0021 0.0965
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0111 0.1685
Schistosoma mansoni tsg101-related 0.006 0.0037 0.0567
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0021 0.1321
Echinococcus granulosus dna polymerase eta 0.002 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0027 0.0682
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.002 0.0718
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0511
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0021 0.0965
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0014 0.0212
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.0077 0.0282
Leishmania major DNA polymerase kappa, putative 0.002 0.0002 0.0009
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0092 0.2391
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.0247 1
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0103 0.1586
Schistosoma mansoni zinc finger protein 0.0022 0.0004 0.0065
Brugia malayi CHE-14 protein 0.0044 0.0023 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0021 0.0738
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0002 0.0008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.002 0.0286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.0247 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0038 0.0574
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.002 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.0247 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.002 0.0718
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0006 0.0023
Schistosoma mansoni lozenge 0.0057 0.0035 0.0535
Mycobacterium tuberculosis Conserved protein 0.0041 0.0021 0.0965
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0073 0.1102
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0028 0.1026
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0002 0.0108
Trypanosoma cruzi ISWI complex protein 0.0017 0 0.0001
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.0142 0.2164
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0077 0.3034
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0006 0.0479
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0002 0.0127
Brugia malayi beta-lactamase 0.0041 0.0021 0.0025
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.0103 0.0331
Brugia malayi beta-lactamase family protein 0.0041 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0052 0.003 0.0756
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0077 0.0282
Schistosoma mansoni DNA polymerase eta 0.002 0.0002 0.0035
Schistosoma mansoni tsg101-related 0.006 0.0037 0.0567
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0044 0.0645
Trypanosoma brucei polo-like protein kinase 0.0106 0.0077 0.0282
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0385
Schistosoma mansoni hypothetical protein 0.0023 0.0005 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0023 0.0841
Echinococcus multilocularis protein dispatched 1 0.005 0.0028 0.0408
Trypanosoma brucei unspecified product 0.002 0.0002 0.0008
Echinococcus multilocularis transfer RNA-Lys 0.0047 0.0025 0.0364
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0006 0.0296
Brugia malayi Pre-SET motif family protein 0.0232 0.0186 0.0253
Loa Loa (eye worm) hypothetical protein 0.0458 0.0383 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0038 0.0549
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0021 0.0075
Onchocerca volvulus 0.0053 0.0031 0.0025
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0021 0.0965
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0006 0.0479
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0021 0.0738
Mycobacterium ulcerans lipase LipD 0.0041 0.0021 0.1737
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.0247 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.3153 0.2721 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0016 0.0018
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0031 0.0451
Toxoplasma gondii RNA-directed DNA polymerase 0.3153 0.2721 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0002 0.0008
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0002 0.0009
Brugia malayi PAS domain containing protein 0.0063 0.004 0.0051
Onchocerca volvulus 0.0041 0.0021 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.0186 0.4851
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.0142 0.0193
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0073 0.29
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0006 0.0296
Giardia lamblia Fructose-bisphosphate aldolase 0.0302 0.0247 0.0901
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Schistosoma mansoni bromodomain containing protein 0.0072 0.0047 0.0724
Echinococcus multilocularis protection of telomeres protein 1 0.0323 0.0266 0.406
Schistosoma mansoni hypothetical protein 0.0064 0.004 0.0619
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.003 0.0038
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.002 0.0024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0006 0.0479
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.0103 0.4894
Echinococcus multilocularis Protein lozenge 0.0057 0.0035 0.0509
Onchocerca volvulus 0.0458 0.0383 0.0376
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.003 0.0038
Mycobacterium ulcerans beta-lactamase 0.0041 0.0021 0.1737
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0006 0.0479
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0261 0.0211 1
Onchocerca volvulus 0.0264 0.0214 0.0208
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0006 0.0162
Leishmania major telomerase reverse transcriptase, putative 0.3153 0.2721 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0075 0.1146
Brugia malayi Pre-SET motif family protein 0.0033 0.0014 0.0016
Trypanosoma cruzi ISWI complex protein 0.0017 0 0.0001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.002 0.0718
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0023 0.0326
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.0103 0.038
Schistosoma mansoni alpha-glucosidase 0.0156 0.0121 0.1848
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0077 0.3034
Loa Loa (eye worm) hypothetical protein 0.008 0.0055 0.1405
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0021 0.0965
Trichomonas vaginalis hypothetical protein 0.0035 0.0016 0.0534
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.0113 0.5357
Brugia malayi Bromodomain containing protein 0.0043 0.0023 0.0028
Echinococcus multilocularis microtubule associated protein 2 0.0768 0.0652 1
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0077 0.3034
Loa Loa (eye worm) hypothetical protein 0.0046 0.0025 0.0633
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0141
Echinococcus granulosus protection of telomeres protein 1 0.0323 0.0266 0.406
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0077 0.3034
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0021 0.0075
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0023 0.0577
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0002 0.0009
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0044 0.0645
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.002 0.0074
Brugia malayi MH2 domain containing protein 0.0124 0.0092 0.0124
Toxoplasma gondii ABC1 family protein 0.0041 0.0021 0.0024
Schistosoma mansoni alpha glucosidase 0.004 0.002 0.0305
Echinococcus granulosus zinc finger protein 0.0022 0.0004 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0006 0.0023
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0031 0.0476
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0072 0.0048 0.0702
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0077 0.3034
Mycobacterium tuberculosis Conserved protein 0.0041 0.0021 0.0965
Leishmania major hypothetical protein, conserved 0.0023 0.0005 0.0019
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.0103 0.1563
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0002 0.0009
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.0239
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.002 0.0718
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0031 0.0451
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0021 0.0738
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0511
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0428 0.0357 0.9322
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0021 0.1737
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.002 0.0279
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0119 0.0088 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0077 0.1176
Onchocerca volvulus 0.0047 0.0026 0.002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.0113 1
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0031 0.0476
Treponema pallidum fructose-bisphosphate aldolase 0.0302 0.0247 0.5
Echinococcus multilocularis dna polymerase kappa 0.002 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0102 0.0073 0.1899
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0001 0.0041
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0021 0.0965
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0002 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0103 0.1586
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.0077 0.1152
Loa Loa (eye worm) hypothetical protein 0.0072 0.0048 0.1219
Leishmania major DNA polymerase eta, putative 0.002 0.0002 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0006 0.0479
Trypanosoma brucei telomerase reverse transcriptase 0.3153 0.2721 1
Schistosoma mansoni single-minded 0.0063 0.004 0.0607
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0005 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0021 0.0738
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.0247 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.002 0.0718
Loa Loa (eye worm) hypothetical protein 0.0053 0.0031 0.0778
Echinococcus granulosus aryl hydrocarbon receptor 0.0136 0.0103 0.1556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0031 0.0469
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0103 0.9128
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0031 0.0791
Plasmodium vivax telomerase reverse transcriptase, putative 0.3153 0.2721 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0021 0.0312
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0023 0.0326
Giardia lamblia Telomerase catalytic subunit 0.3153 0.2721 1
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0031 0.0451
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0073 0.1102
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0002 0.0127
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0002 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0006 0.0005
Schistosoma mansoni tsg101-related 0.0049 0.0028 0.0421
Leishmania major alpha glucosidase II subunit, putative 0.004 0.002 0.0074
Echinococcus multilocularis aryl hydrocarbon receptor 0.0136 0.0103 0.1556
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0001 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.002 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0021 0.0287
Echinococcus multilocularis protein patched 0.0044 0.0023 0.0326
Schistosoma mansoni hypothetical protein 0.0042 0.0022 0.033
Schistosoma mansoni microtubule-associated protein tau 0.0768 0.0652 1
Brugia malayi beta-lactamase family protein 0.0041 0.0021 0.0025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0021 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0021 0.0312
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0007 0.0109
Mycobacterium ulcerans putative regulatory protein 0.0047 0.0025 0.2182
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0023 0.0326
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0002 0.0035
Onchocerca volvulus 0.0105 0.0076 0.007
Brugia malayi hypothetical protein 0.0458 0.0383 0.0524
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 0.0247 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0103 0.9128
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0072 0.0048 0.0702
Loa Loa (eye worm) hypothetical protein 0.0135 0.0103 0.266
Schistosoma mansoni aryl hydrocarbon receptor 0.0182 0.0143 0.2198
Loa Loa (eye worm) hypothetical protein 0.0064 0.004 0.1035
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0511
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0013 0.0169
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0038 0.0549
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0801
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0006 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0021 0.0738
Schistosoma mansoni hypothetical protein 0.0042 0.0022 0.033
Schistosoma mansoni hypothetical protein 0.0042 0.0022 0.033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.0247 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0006 0.0162
Echinococcus granulosus dna polymerase kappa 0.002 0.0002 0.0009
Loa Loa (eye worm) beta-lactamase 0.0041 0.0021 0.0511
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0007 0.0083
Echinococcus multilocularis zinc finger protein 0.0022 0.0004 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0092 0.2391
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.002 0.0718
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.0077 0.007
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.002 0.0279
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.002 0.0718
Echinococcus multilocularis expressed conserved protein 0.0096 0.0068 0.1019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.002 0.0286
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0038 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0006 0.0005
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0038 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0077 0.3034
Brugia malayi Bromodomain containing protein 0.0085 0.0059 0.0078
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0021 0.0511
Mycobacterium ulcerans hypothetical protein 0.0025 0.0006 0.0479
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0103 0.9128
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0073 0.0098
Loa Loa (eye worm) hypothetical protein 0.0119 0.0088 0.2288
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0142 0.2164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0014 0.0212
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0511
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.0167 0.2536
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0111 0.1685
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.0167 0.2536
Leishmania major hypothetical protein, conserved 0.0041 0.0021 0.0075
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.0077 0.1152
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0038 0.0549
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0021 0.0965
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0031 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0031 0.0444
Schistosoma mansoni hypothetical protein 0.0323 0.0265 0.4068
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.0103 0.1563
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.0077 0.3034
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0021 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.0247 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0002 0.0108
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0002 0.0026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0021 0.1737
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.002 0.0718
Schistosoma mansoni hypothetical protein 0.0042 0.0022 0.033
Loa Loa (eye worm) hypothetical protein 0.0044 0.0023 0.0577
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.0077 0.0102
Brugia malayi Telomerase reverse transcriptase 0.8391 0.7265 1
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0077 0.3034
Mycobacterium leprae Probable lipase LipE 0.0041 0.0021 0.1321
Plasmodium falciparum telomerase reverse transcriptase 0.3153 0.2721 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0002 0.0008
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0005 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0008
Onchocerca volvulus 0.0033 0.0014 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0031 0.1153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0141
Loa Loa (eye worm) runx1 0.0057 0.0035 0.089
Loa Loa (eye worm) hypothetical protein 0.0053 0.0031 0.0791
Brugia malayi bHLH-PAS transcription factor 0.0047 0.0025 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0031 0.0469
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0006 0.0479
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.002 0.0718

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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