Detailed information for compound 1068926

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 532.503 | Formula: C22H27Cl2N3O4S2
  • H donors: 1 H acceptors: 3 LogP: 3.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C1CCN(CC1)S(=O)(=O)c1cc(Cl)ccc1Cl)NCC(c1cccs1)N1CCOCC1
  • InChi: 1S/C22H27Cl2N3O4S2/c23-17-3-4-18(24)21(14-17)33(29,30)27-7-5-16(6-8-27)22(28)25-15-19(20-2-1-13-32-20)26-9-11-31-12-10-26/h1-4,13-14,16,19H,5-12,15H2,(H,25,28)
  • InChiKey: HXXBBHLJCGHXGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cytochrome p450-like protein 0.0028 0.0313 0.6145
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.0313 1
Loa Loa (eye worm) sugar transporter 0.0103 0.2094 0.4199
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.0313 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Brugia malayi hypothetical protein 0.0019 0.0111 0.0223
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.0313 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0404 0.0809
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.0313 1
Trypanosoma brucei glucose transporter 2A 0.0032 0.0413 0.8107
Schistosoma mansoni protein kinase 0.0031 0.0404 0.1702
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2094 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1973
Brugia malayi follicle stimulating hormone receptor 0.0224 0.4987 1
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0201 0.0404
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.0313 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1473 0.6214
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0404 0.0404
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0313 0.6145
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.0313 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.0313 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0111 0.0468
Brugia malayi hypothetical protein 0.0019 0.0111 0.0223
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.8832
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0313 0.6145
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.0313 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.0313 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1473 0.2955
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.0313 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1473 0.6214
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.2371 1
Schistosoma mansoni lipoxygenase 0.0114 0.2371 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.8832
Schistosoma mansoni protein kinase 0.0031 0.0404 0.1702
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0849
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0201 0.0849
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Echinococcus granulosus General substrate transporter 0.0088 0.1752 0.7387
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3595 0.5495
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.0313 1
Trypanosoma cruzi hexose transporter 0.0032 0.0413 0.8107
Echinococcus granulosus tar DNA binding protein 0.0076 0.1473 0.6214
Toxoplasma gondii protein kinase, putative 0.029 0.6542 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.2371 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 1
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.8832
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0961
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.0313 1
Echinococcus granulosus RUN 0.0019 0.0111 0.0468
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.8832
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.1702
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.0313 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.0313 1
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0357 0.1507
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0468
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0404 0.0404
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0201 0.0201
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.0313 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1473 0.2955
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0849
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.1642 0.3293
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.1638
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0111 0.0468
Schistosoma mansoni lipoxygenase 0.008 0.1555 0.6556
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.0313 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Leishmania major cytochrome p450-like protein 0.0028 0.0313 0.6145
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.8832
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.0313 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0388 0.1855
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0388 0.9253
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0404 0.1702
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1473 0.6214
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.1702
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.1973
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.0313 1
Brugia malayi RNA binding protein 0.0076 0.1473 0.2955
Entamoeba histolytica protein kinase, putative 0.0031 0.0404 1
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0357 0.1507
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0404 0.0404
Brugia malayi Cytochrome P450 family protein 0.0084 0.1642 0.3293
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0404 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.1702
Brugia malayi Cytochrome P450 family protein 0.0028 0.0313 0.0628
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0119 0.381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0779
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3595 0.3595
Brugia malayi Sugar transporter family protein 0.0103 0.2094 0.4199
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1473 0.6214
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.0313 1
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.8832
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.4987 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2094 0.8832
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.051 0.0779
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.0313 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0388 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0404 0.0809
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1473 0.2955
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0404 0.0404
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.1702
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.0313 1
Schistosoma mansoni loxhd1 0.0019 0.0111 0.0468
Mycobacterium leprae putative cytochrome p450 0.0028 0.0313 0.7203
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.0313 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0201 0.5182
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0111 0.0468
Echinococcus multilocularis 0.0028 0.0313 0.1321
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2094 0.3201
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.0313 1
Schistosoma mansoni rab6-interacting 0.0019 0.0111 0.0468
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.1973
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.0313 1
Leishmania major cytochrome p450-like protein 0.0028 0.0313 0.6145
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.0313 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1973
Plasmodium vivax hexose transporter 0.0103 0.2094 0.2094
Loa Loa (eye worm) RNA binding protein 0.0076 0.1473 0.2955
Loa Loa (eye worm) hypothetical protein 0.0031 0.0404 0.0809
Leishmania major glucose transporter, lmgt1 0.0032 0.0413 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.1702
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Plasmodium falciparum proline--tRNA ligase 0.0036 0.051 0.051
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.0313 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0313 0.6145
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.0313 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Brugia malayi cytochrome P450 0.0028 0.0313 0.0628
Schistosoma mansoni rab6-interacting 0.0019 0.0111 0.0468
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0201 0.5
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3595 0.3595
Onchocerca volvulus 0.0019 0.0111 1
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0313 0.6145
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.6428
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.0313 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.0313 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0313 1
Echinococcus multilocularis RUN 0.0019 0.0111 0.0468
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Brugia malayi Doublecortin family protein 0.0019 0.0111 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0404 0.1702
Brugia malayi Cam kinase protein 1 0.0031 0.0404 0.0809
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0404 0.0617
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0404 0.0404
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.3046
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.8832
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0111 0.0468
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1473 0.6214
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0404 0.0404
Brugia malayi TAR-binding protein 0.0076 0.1473 0.2955
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0201 0.0201
Schistosoma mansoni cytochrome P450 0.0028 0.0313 0.1321
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.8832
Leishmania major glucose transporter, lmgt3 0.0032 0.0413 0.8107
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0111 0.0468
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0313 0.6145
Plasmodium falciparum protein kinase 7 0.029 0.6542 0.6542
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0404 0.0404
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0201 0.0308
Echinococcus multilocularis General substrate transporter 0.0088 0.1752 0.7387
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0111 0.0468
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0111 0.0111
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.1973
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.6428
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.8832
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0111 0.0223
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0413 0.8107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0119 0.381
Schistosoma mansoni hypothetical protein 0.0028 0.0313 0.1321
Brugia malayi Cytochrome P450 family protein 0.0028 0.0313 0.0628
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0779
Trypanosoma brucei glucose transporter 1E 0.0032 0.0413 0.8107
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0313 0.0628
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0313 0.0628
Onchocerca volvulus 0.0019 0.0111 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.0313 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0404 0.0617
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.1638
Schistosoma mansoni hypothetical protein 0.0103 0.2094 0.8832
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0404 0.0404
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0404 0.7919
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1973
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0223
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0313 0.0628
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.0313 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.0313 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.1973
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1473 0.6214
Leishmania major protein kinase, putative 0.0031 0.0404 0.7919
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.0313 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0313 0.6145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0223
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0251 0.0504
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0313 0.1321
Leishmania major glucose transporter, lmgt2 0.0032 0.0413 0.8107
Loa Loa (eye worm) cytochrome P450 0.0028 0.0313 0.0628
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0111 0.0468
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.051 0.051
Mycobacterium leprae Conserved hypothetical protein 0.0028 0.0313 0.7203
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0404 0.0617
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.0313 1
Plasmodium falciparum hexose transporter 0.0103 0.2094 0.2094
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0779
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.1702
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0313 0.6145
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0134 0.0641
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.8832
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.0313 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0404 0.0809
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0111 0.0111
Trypanosoma cruzi hexose transporter, putative 0.0017 0.007 0.1383
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0313 0.0479
Entamoeba histolytica protein kinase, putative 0.0031 0.0404 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.0313 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.1638
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.0313 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0313 0.6145
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0388 1
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0404 0.1927
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.1702
Brugia malayi Cytochrome P450 family protein 0.0028 0.0313 0.0628
Schistosoma mansoni protein kinase 0.0031 0.0404 0.1702
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.1638
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0201 0.0849
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0779

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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