Detailed information for compound 107606

Basic information

Technical information
  • TDR Targets ID: 107606
  • Name: ethyl 5-bromoimidazo[1,2-a]pyrazine-2-carboxy late
  • MW: 270.083 | Formula: C9H8BrN3O2
  • H donors: 0 H acceptors: 3 LogP: 2.27 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cn2c(n1)cncc2Br
  • InChi: 1S/C9H8BrN3O2/c1-2-15-9(14)6-5-13-7(10)3-11-4-8(13)12-6/h3-5H,2H2,1H3
  • InChiKey: SHEPHIOFWBYNCL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-bromo-2-imidazo[1,2-a]pyrazinecarboxylic acid ethyl ester
  • 5-bromoimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi major facilitator superfamily protein 0.0031 0.0254 0.0319
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0254 0.5639
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0656 0.8747
Schistosoma mansoni chromobox protein 0.0073 0.0711 0.0947
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0053 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0049 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.011 0.0289
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0189 0.0481
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0246
Schistosoma mansoni protein kinase 0.0067 0.0647 0.0862
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0009 0.0012
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0049 0.045 0.1552
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0048 0.0051
Schistosoma mansoni glucose transporter 0.0031 0.0254 0.0338
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0048 0.0064
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.2131 0.2763
Onchocerca volvulus 0.0031 0.0254 0.1183
Onchocerca volvulus 0.0012 0.0048 0.0064
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0048 0.0064
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0048 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0049 0.017
Brugia malayi Sugar transporter family protein 0.0031 0.0254 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0036 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1874 0.6466
Onchocerca volvulus 0.0031 0.0254 0.1183
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0049 0.045 0.5996
Leishmania major glucose transporter, lmgt3 0.0068 0.0656 0.8747
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Schistosoma mansoni sugar transporter 0.0031 0.0254 0.0338
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0171 1
Echinococcus granulosus somatostatin receptor 0.0012 0.0048 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0036 0.0036
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0036 0.0041
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0053 0.0062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0329 0.0427
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0189 0.0235
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0077 0.075 0.1132
Plasmodium vivax lysine--tRNA ligase, putative 0.0049 0.045 0.045
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0711 0.0925
Schistosoma mansoni hypothetical protein 0.0012 0.0048 0.0064
Schistosoma mansoni sugar transporter 0.0031 0.0254 0.0338
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0038 0.0504
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2555 0.3402
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0064
Plasmodium falciparum calcium-dependent protein kinase 1 0.0067 0.0647 0.0647
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0011 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.0243 0.2555 0.3323
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0048 0.0054
Brugia malayi ORL1-like opioid receptor 0.0012 0.0048 0.0051
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0122 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus multilocularis chromobox protein 1 0.0073 0.0711 0.0794
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.8747
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0254 0.0875
Echinococcus multilocularis chromobox protein 2 0.0012 0.0049 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0036 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0064
Brugia malayi major facilitator superfamily protein 0.0031 0.0254 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Echinococcus granulosus g protein coupled receptor 0.0012 0.0048 0.0064
Schistosoma mansoni opsin-like receptor 0.0012 0.0048 0.0064
Giardia lamblia Prolyl-tRNA synthetase 0.0066 0.0632 0.1493
Schistosoma mansoni sugar transporter 0.0031 0.0254 0.0338
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0254 0.033
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0329 0.0427
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.1874 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.017
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0012 0.0053 0.2103
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.075 1
Entamoeba histolytica hypothetical protein 0.0012 0.0049 0.0125
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0711 0.2453
Brugia malayi G-protein coupled receptor 0.0012 0.0048 0.0051
Onchocerca volvulus 0.0031 0.0254 0.1183
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0036 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0056 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0049 0.017
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0036 0.0048
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0254 0.0319
Onchocerca volvulus Putative transporter 0.0031 0.0254 0.1183
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Echinococcus granulosus chromobox protein 2 0.0012 0.0049 0.0066
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0038 0.0504
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0049 0.045 0.5996
Loa Loa (eye worm) hypothetical protein 0.0066 0.0632 0.0822
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0048 0.0054
Echinococcus granulosus geminin 0.0701 0.7509 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0048 0.0054
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.037 0.1331
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.0302
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0036 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Brugia malayi Doublecortin family protein 0.002 0.0136 0.0165
Echinococcus granulosus dnaJ subfamily B 0.0414 0.4404 0.5865
Plasmodium vivax sugar transporter, putative 0.0031 0.0254 0.0254
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0048 0.0051
Schistosoma mansoni smad1 5 8 and 0.0008 0.0009 0.0012
Mycobacterium tuberculosis Conserved protein 0.0038 0.0329 0.1166
Brugia malayi lysyl-tRNA synthetase 0.0049 0.045 0.0574
Schistosoma mansoni neuropeptide receptor 0.0012 0.0048 0.0064
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0048 0.0054
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0711
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0136 0.0136
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0254 0.0338
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0036 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0036 0.0041
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0121 0.0416
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0048 0.0064
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0048 0.0064
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0036 0.0048
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.8747
Trichomonas vaginalis esterase, putative 0.0038 0.0329 0.1134
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0048 0.0054
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0038 0.0504
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0157
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0048 0.0064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0412 0.0524
Chlamydia trachomatis lysine--tRNA ligase 0.0049 0.045 1
Brugia malayi hypothetical protein 0.0243 0.2555 0.3315
Schistosoma mansoni smad1 5 8 and 0.0008 0.0009 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0036 0.0047
Brugia malayi hypothetical protein 0.002 0.0136 0.0165
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0711
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Echinococcus multilocularis General substrate transporter 0.0189 0.1961 0.2189
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0254 0.0875
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0049 0.0055
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0048 0.0064
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0088 0.0302
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0049 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0048 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0412 0.046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0267 0.0348
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0049 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Echinococcus multilocularis solute carrier family 22 0.0031 0.0254 0.0283
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0048 0.0054
Echinococcus granulosus Chromobox protein 3 0.0012 0.0049 0.0066
Brugia malayi Heterochromatin protein 1 0.0073 0.0711 0.0914
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0036 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Leishmania major hypothetical protein, conserved 0.0011 0.0038 0.0504
Entamoeba histolytica protein kinase, putative 0.0067 0.0647 0.1646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0048 0.0064
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0254 0.0383
Schistosoma mansoni biogenic amine receptor 0.0012 0.0048 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0036 0.0048
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.0862
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0122 0.1626
Brugia malayi hypothetical protein 0.0031 0.0254 0.0319
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0122 0.0147
Schistosoma mansoni glucose transport protein 0.0219 0.2295 0.3056
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0067 0.0647 0.0976
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0036 0.0048
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0355 0.3758 0.5667
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0329 0.1166
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0121 0.0121
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0136 0.0181
Onchocerca volvulus 0.0012 0.0049 0.007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0036 0.0036
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0048 0.0051
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0049 0.0055
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0397 0.137
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0048 0.0054
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.075 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2295 0.3056
Leishmania major hypothetical protein, conserved 0.0031 0.0254 0.3381
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.0125
Echinococcus multilocularis serotonin receptor 0.0012 0.0048 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0254 0.0875
Echinococcus multilocularis sex peptide receptor 0.0012 0.0048 0.0054
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0049 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0122 0.0421
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0048 0.0054
Onchocerca volvulus 0.0013 0.0056 0.0108
Echinococcus granulosus solute carrier family 22 0.0031 0.0254 0.0338
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0053 0.0071
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0049 0.0066
Schistosoma mansoni biogenic amine receptor 0.0012 0.0048 0.0064
Onchocerca volvulus 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0121 0.0416
Brugia malayi G-protein coupled receptor 0.0012 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0329 0.0427
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0619 0.0795
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0049 0.0066
Schistosoma mansoni survival motor neuron protein 0.005 0.0457 0.0609
Brugia malayi steroid hormone receptor 0.0011 0.0036 0.0036
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0048 0.0054
Mycobacterium tuberculosis Conserved protein 0.0038 0.0329 0.1166
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0189 0.4202
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0048 0.0063
Schistosoma mansoni hypothetical protein 0.0219 0.2295 0.3056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.011 0.0289
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0189 0.2519
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.0053 0.3113
Brugia malayi RE15519p 0.0012 0.0048 0.0051
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0036 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Brugia malayi follicle stimulating hormone receptor 0.0718 0.7689 1
Onchocerca volvulus 0.0038 0.0329 0.1591
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni amine GPCR 0.0012 0.0048 0.0064
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0048 0.0064
Echinococcus multilocularis somatostatin receptor 0.0012 0.0048 0.0054
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2555 0.2853
Schistosoma mansoni lipoxygenase 0.0119 0.1213 0.1615
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0053 0.0069
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0619 0.0825
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0275 0.2899 0.377
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.0069
Brugia malayi Serotonin receptor 0.0012 0.0048 0.0051
Onchocerca volvulus 0.0031 0.0254 0.1183
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.0722
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0157
Brugia malayi CXXC zinc finger family protein 0.0029 0.0235 0.0294
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0048 0.0064
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0067 0.0647 0.0831
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Onchocerca volvulus 0.0012 0.0048 0.0064
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.0862
Onchocerca volvulus 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0177
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0036 0.0048
Echinococcus granulosus g protein coupled receptor 0.0012 0.0048 0.0064
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0397 0.1962
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0036 0.0048
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0048 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.2899 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0036 0.0036
Leishmania major protein kinase, putative 0.0067 0.0647 0.8623
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0254 0.0875
Echinococcus multilocularis solute carrier family 22 0.0031 0.0254 0.0283
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.017
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.075 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Plasmodium falciparum mitogen-activated protein kinase 2 0.0355 0.3758 0.3758
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0181
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0066 0.0632 0.0812
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0048 0.0051
Plasmodium falciparum lysine--tRNA ligase 0.0049 0.045 0.045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0122 0.0136
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0048 0.0064
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0122 0.2711
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0329 0.1166
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0656 0.2264
Echinococcus granulosus lysyl tRNA synthetase 0.0049 0.045 0.0599
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0412 0.0535
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0121 0.0121
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0048 0.0064
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0632 0.0842
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0329 0.0367
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0067 0.0647 0.0841
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0254 0.0254
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1874 0.6466
Leishmania major hypothetical protein, conserved 0.0038 0.0329 0.438
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0043 0.0385 0.1327
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0048 0.0064
Schistosoma mansoni smad 0.0008 0.0009 0.0012
Onchocerca volvulus 0.0038 0.0329 0.1591
Schistosoma mansoni hypothetical protein 0.0012 0.0048 0.0064
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0049 0.0053
Echinococcus multilocularis solute carrier family 22 0.0031 0.0254 0.0283
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0246
Schistosoma mansoni amine GPCR 0.0012 0.0048 0.0064
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0254 0.0865
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0012 0.0053 0.2103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0036 0.0047
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0656 0.8747
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0189 0.0606
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Schistosoma mansoni hypothetical protein 0.0012 0.0048 0.0064
Entamoeba histolytica hypothetical protein 0.0012 0.0049 0.0125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.011 0.0289
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0619 0.0825
Schistosoma mansoni ap endonuclease 0.0019 0.0122 0.0162
Loa Loa (eye worm) sugar transporter 0.0031 0.0254 0.033
Schistosoma mansoni amine GPCR 0.0012 0.0048 0.0064
Onchocerca volvulus 0.0012 0.0048 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0049 0.017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.2131 0.2772
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.2899 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0711
Onchocerca volvulus 0.0031 0.0254 0.1183
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0036 0.0047
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.075 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0363 0.0473
Toxoplasma gondii ABC1 family protein 0.0038 0.0329 0.0496
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0254 0.3381
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0066 0.0632 0.0812
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0066 0.0632 0.2181
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0048 0.0064
Schistosoma mansoni rab6-interacting 0.002 0.0136 0.0181
Schistosoma mansoni opsin-like receptor 0.0012 0.0048 0.0064
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0053 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.2131 0.2763
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0329 0.0427
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0048 0.0064
Echinococcus granulosus GPCR family 2 0.0065 0.0619 0.0825
Brugia malayi hypothetical protein 0.002 0.0136 0.0165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0329 0.0416
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0122 0.0177
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0049 0.0053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0121 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0036 0.0047
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0329 0.0427
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0048 0.0064
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0049 0.0053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0189 0.2544
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0329 0.1134
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0619 0.0806
Echinococcus granulosus General substrate transporter 0.0189 0.1961 0.2611
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2295 0.7917
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0064
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0053 0.0053
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Schistosoma mansoni protein kinase 0.0067 0.0647 0.0862
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0049 0.0049
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0048 0.0064
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0038 0.0504
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0067 0.0647 0.8623
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0122 0.0159
Schistosoma mansoni loxhd1 0.002 0.0136 0.0181
Echinococcus granulosus solute carrier family 22 0.0031 0.0254 0.0338
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1229 0.1598
Leishmania major glucose transporter, lmgt1 0.0068 0.0656 0.8747
Trichomonas vaginalis hypothetical protein 0.0012 0.0049 0.017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0329 0.0438
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0457 0.0584
Schistosoma mansoni glucose transport protein 0.0219 0.2295 0.3056
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0329 0.1166
Onchocerca volvulus 0.0031 0.0254 0.1183
Giardia lamblia Sugar-proton symporter 0.0031 0.0254 0.0517
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0711 0.2453
Onchocerca volvulus 0.0012 0.0048 0.0064
Echinococcus granulosus smad 0.0008 0.0009 0.0012
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0275 0.2899 0.3763
Onchocerca volvulus 0.0031 0.0254 0.1183
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1229 0.1598
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0329 0.1134
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0067 0.0647 0.0647
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0189 0.2519
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2295 0.2562
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0036 0.0048
Leishmania major hypothetical protein, conserved 0.0011 0.0038 0.0504
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0023
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0254 0.3381
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0246
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.2532 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0048 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1874 0.6466
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0656 0.2264
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0171 0.3811
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0053 0.006
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0053 0.0053
Onchocerca volvulus 0.0012 0.0048 0.0064
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0048 0.0064
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.8747
Brugia malayi Melatonin receptor type 1A 0.0012 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0656 0.2264
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0048 0.0064
Onchocerca volvulus 0.0012 0.0048 0.0064
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0122 0.1626
Schistosoma mansoni neuropeptide receptor 0.0012 0.0048 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0036 0.0036
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0048 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Onchocerca volvulus 0.0012 0.0048 0.0064
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0254 0.0319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0121 0.0416
Loa Loa (eye worm) sugar transporter 0.0219 0.2295 0.2985
Schistosoma mansoni hypothetical protein 0.0701 0.7509 1
Onchocerca volvulus 0.0012 0.0048 0.0064
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0048 0.0054
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0036 0.0048
Echinococcus granulosus sex peptide receptor 0.0012 0.0048 0.0064
Mycobacterium ulcerans beta-lactamase 0.0038 0.0329 0.7306
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0048 0.0054
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0048 0.0054
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0036 0.0048
Schistosoma mansoni cpg binding protein 0.0029 0.0235 0.0312
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0329 0.0438
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.0065 0.0619 0.0806
Brugia malayi beta-lactamase family protein 0.0038 0.0329 0.0416
Entamoeba histolytica hypothetical protein 0.0012 0.0049 0.0125
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0656 0.2264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2295 0.3056
Loa Loa (eye worm) hypothetical protein 0.0066 0.0632 0.0822
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0254 0.0338
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0048 0.0064
Onchocerca volvulus 0.0012 0.0048 0.0064
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0048 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0254 0.0338
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus granulosus cpg binding protein 0.0031 0.0253 0.0336
Schistosoma mansoni protein kinase 0.0067 0.0647 0.0862
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0049 0.017
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0189 0.4202
Schistosoma mansoni hypothetical protein 0.005 0.0457 0.0609
Brugia malayi chromobox protein homolog 3 0.0041 0.0363 0.0461
Brugia malayi MH2 domain containing protein 0.0121 0.1229 0.1588
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0067 0.0647 0.0647
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0121 0.0416
Loa Loa (eye worm) doublecortin family protein 0.002 0.0136 0.0177
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0121 0.0333
Onchocerca volvulus 0.0029 0.0235 0.1079
Brugia malayi Dopamine receptor 0.0012 0.0048 0.0051
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0136
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0048 0.0054
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0329 0.1134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni neuropeptide receptor 0.0012 0.0048 0.0064
Plasmodium vivax calcium-dependent protein kinase, putative 0.0067 0.0647 0.0647
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0122 0.031
Echinococcus granulosus hypothetical protein 0.0012 0.0048 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0412 0.046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0122 0.1626
Entamoeba histolytica hypothetical protein 0.0105 0.1061 0.2699
Brugia malayi hypothetical protein 0.0031 0.0254 0.0319
Brugia malayi hypothetical protein 0.0012 0.0049 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0189 0.0235
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.1213 0.1354
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2295 0.3056
Schistosoma mansoni rab6-interacting 0.002 0.0136 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1979 0.6829
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2295 0.3056
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0835 0.8956 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0048 0.0064
Echinococcus multilocularis geminin 0.0701 0.7509 0.8384
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0036 0.0048
Onchocerca volvulus 0.0031 0.0254 0.1183
Giardia lamblia Lysyl-tRNA synthetase 0.0049 0.045 0.1023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0009 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0036 0.0036
Schistosoma mansoni neuropeptide receptor 0.0012 0.0048 0.0064
Schistosoma mansoni Smad4 0.0008 0.0009 0.0012
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0329 0.4893
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.045 0.0599
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2295 0.2562
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0048 0.0064
Toxoplasma gondii sugar transporter ST3 0.0031 0.0254 0.0383
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0049 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0329 0.0427
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0064
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0067 0.0647 0.0647
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0036 0.0048
Onchocerca volvulus 0.0031 0.0254 0.1183
Echinococcus multilocularis smad 0.0008 0.0009 0.001
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0053 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0121 0.0416
Schistosoma mansoni polycystin 1-related 0.002 0.0136 0.0181
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.8747
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0048 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1874 0.6466
Echinococcus multilocularis Chromo domain 0.0012 0.0049 0.0055
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0048 0.0054
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0048 0.0054
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.1431 0.1852
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0053 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni hypothetical protein 0.0065 0.0619 0.0825
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0136 0.0152
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.037 0.5587
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0048 0.0064
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0048 0.0064
Mycobacterium ulcerans hypothetical protein 0.0011 0.0038 0.0841
Onchocerca volvulus 0.0012 0.0048 0.0064
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0619 0.0692
Brugia malayi Sugar transporter family protein 0.0219 0.2295 0.2976
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0049 0.045 0.6932
Onchocerca volvulus 0.005 0.0457 0.229
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0049 0.017
Entamoeba histolytica protein kinase, putative 0.0067 0.0647 0.1646
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni biogenic amine receptor 0.0012 0.0048 0.0064
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0329 0.1134
Onchocerca volvulus 0.0031 0.0254 0.1183
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0036 0.0036
Brugia malayi putative neuropeptide receptor 0.0012 0.0048 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0647 0.2232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0189 0.0606
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0053 0.0711
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0329 0.7306
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0048 0.0054
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0066 0.0632 1
Brugia malayi nuclear hormone receptor 0.0011 0.0036 0.0036
Echinococcus granulosus calcium dependent protein kinase 0.0063 0.0602 0.0802
Schistosoma mansoni cpg binding protein 0.0031 0.0253 0.0336
Onchocerca volvulus 0.0012 0.0049 0.007
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0048 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0412 0.0548
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0189 0.0481
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0235 0.0305
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0049 0.0049
Echinococcus granulosus neuropeptide receptor 0.0012 0.0048 0.0064
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0212 0.0276
Echinococcus multilocularis chromobox protein 1 0.0073 0.0711 0.0794
Schistosoma mansoni chromobox protein 0.0012 0.0049 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0412 0.0548
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0036 0.0036
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0053 0.0071
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0048 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus granulosus chromobox protein 1 0.0073 0.0711 0.0947
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0053 0.0136
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0254 0.3381
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0053 0.1186
Echinococcus multilocularis GPCR, family 2 0.0065 0.0619 0.0692
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0053 0.0071
Plasmodium vivax proline--tRNA ligase, putative 0.0077 0.075 0.075
Loa Loa (eye worm) Smad1 0.0008 0.0009 0.0012
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0048 0.0064
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0048 0.0054
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Mycobacterium ulcerans hypothetical protein 0.0038 0.0329 0.7306
Onchocerca volvulus 0.0031 0.0254 0.1183
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0355 0.3758 0.3758
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0048 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0619 0.0795
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0329 0.0438
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0157
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0067 0.009
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0048 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0412 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0363 0.1253
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0189 0.4202
Echinococcus granulosus allatostatin A receptor 0.0012 0.0048 0.0064
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0066 0.0632 0.0842
Echinococcus granulosus solute carrier family 22 0.0031 0.0254 0.0338
Loa Loa (eye worm) helicase 0.0012 0.0049 0.0064
Schistosoma mansoni smad1 5 8 and 0.0008 0.0009 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0049 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0036 0.0047
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0048 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0189 0.0235
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.0722
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0136 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0009 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0329 0.1166
Schistosoma mansoni hypothetical protein 0.0021 0.0145 0.0193
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0329 0.1166
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0329 0.1166
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0048 0.0054
Brugia malayi AKH receptor 0.0012 0.0048 0.0051
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0048 0.0064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0036 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0036 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0036 0.0041
Echinococcus granulosus fmrfamide receptor 0.0012 0.0048 0.0064
Onchocerca volvulus 0.002 0.0136 0.0542
Brugia malayi Cam kinase protein 1 0.0067 0.0647 0.0831
Schistosoma mansoni hypothetical protein 0.0414 0.4404 0.5865
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Brugia malayi beta-lactamase family protein 0.0038 0.0329 0.0416
Brugia malayi hypothetical protein 0.0031 0.0254 0.0319
Plasmodium vivax CDK-related protein kinase 6, putative 0.0931 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0065 0.0619 0.0825
Echinococcus granulosus g protein coupled receptor 0.0012 0.0048 0.0064
Brugia malayi Sugar transporter family protein 0.0031 0.0254 0.0319
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.2899 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.045 1
Schistosoma mansoni opsin-like receptor 0.0012 0.0048 0.0064
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0066 0.0632 0.1609
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0048 0.0064
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0036 0.0041
Onchocerca volvulus 0.0025 0.0189 0.0831
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0066 0.0632 0.0706
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Schistosoma mansoni amine GPCR 0.0012 0.0048 0.0064
Plasmodium vivax hexose transporter 0.0219 0.2295 0.2295
Loa Loa (eye worm) beta-lactamase 0.0038 0.0329 0.0427
Brugia malayi G protein-coupled receptor 0.0012 0.0048 0.0051
Onchocerca volvulus 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0157
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0656 0.8747
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0048 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0234 0.0807
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0036 0.0036
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0219 0.2295 0.2562
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1874 0.6466
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0048 0.0054
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0049 0.0049
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0048 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0048 0.0054
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Schistosoma mansoni lipoxygenase 0.0084 0.0824 0.1097
Echinococcus granulosus neuropeptide receptor 0.0012 0.0048 0.0064
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0048 0.0054
Onchocerca volvulus 0.0038 0.0329 0.1591
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0189 0.4202
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0322 0.4296
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0122 0.0337
Schistosoma mansoni hypothetical protein 0.0065 0.0619 0.0825
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0122 0.7115
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.1213 0.1615
Toxoplasma gondii sugar transporter ST1 0.0031 0.0254 0.0383
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0048 0.0064
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0009 0.0012
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Mycobacterium leprae Probable lipase LipE 0.0038 0.0329 0.4893
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Plasmodium falciparum calcium-dependent protein kinase 4 0.0067 0.0647 0.0647
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0048 0.0054
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0048 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0412 0.0548
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0053 0.008
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0204 0.2131 0.2772
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0718 0.7689 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0036 0.0036
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0067 0.0087
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0048 0.0054
Onchocerca volvulus 0.0031 0.0254 0.1183
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0105 0.1061 0.2699
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0136 0.0136
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0048 0.0064
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0036 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0048 0.0054
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0048 0.0054
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0064
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0048 0.0063
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0122 0.1626
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0067 0.0647 0.0841
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0017 0.0022
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0136 0.0181
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0036 0.0036
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0048 0.0054
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0189 0.2519
Onchocerca volvulus 0.0012 0.0048 0.0064
Onchocerca volvulus 0.002 0.0136 0.0542
Echinococcus multilocularis serotonin receptor 0.0012 0.0048 0.0054
Plasmodium falciparum proline--tRNA ligase 0.0077 0.075 0.075
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0254 0.3381
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0048 0.0064
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0254 0.3381
Schistosoma mansoni myosin xvIII 0.0012 0.0048 0.0064
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0516 0.0779
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0656 0.8747
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0048 0.0063
Echinococcus multilocularis cpg binding protein 0.0031 0.0253 0.0282
Schistosoma mansoni hypothetical protein 0.0701 0.7509 1
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0048 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0049 0.0049
Plasmodium falciparum protein kinase 7 0.062 0.663 0.663
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0632 0.0842
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0048 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Echinococcus multilocularis lysyl tRNA synthetase 0.0049 0.045 0.0502
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.0067 0.0647 0.0841
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0254 0.0283
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0254 0.0875
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.045 0.0599
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.011 0.0289
Toxoplasma gondii sugar transporter ST2 0.0031 0.0254 0.0383
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Brugia malayi Protein cec-1. 0.0012 0.0049 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0049 0.017
Schistosoma mansoni amine GPCR 0.0012 0.0048 0.0064
Schistosoma mansoni chromobox protein 0.0073 0.0711 0.0947
Toxoplasma gondii exonuclease III APE 0.0019 0.0122 0.0184
Brugia malayi neuropeptide F receptor 0.0012 0.0048 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0329 0.1134
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.037 0.1331
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.0862
Plasmodium falciparum calcium-dependent protein kinase 3 0.0067 0.0647 0.0647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0053 0.0499 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0234 0.0807
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0171 0.3811
Trypanosoma cruzi hexose transporter 0.0068 0.0656 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Schistosoma mansoni chromobox protein 0.0012 0.0049 0.0066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0036 0.0041
Echinococcus granulosus Chromo domain 0.0012 0.0049 0.0066
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0048 0.0051
Brugia malayi CHD4 protein 0.0014 0.0067 0.0076
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0189 0.0481
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0254 0.5639
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0121 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0122 0.0122
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0048 0.0063
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0254 0.0875
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0064
Toxoplasma gondii facilitative glucose transporter GT1 0.0219 0.2295 0.3461
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0036 0.0048
Onchocerca volvulus 0.0031 0.0254 0.1183
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0048 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0049 0.017
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.8747
Schistosoma mansoni adenoreceptor 0.0012 0.0048 0.0064
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.0722
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0189 0.4202
Plasmodium falciparum calcium-dependent protein kinase 2 0.0067 0.0647 0.0647
Trypanosoma brucei glucose transporter 2A 0.0068 0.0656 0.8747
Brugia malayi ecdysteroid receptor 0.0011 0.0036 0.0036
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0189 0.4202
Onchocerca volvulus 0.0031 0.0254 0.1183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0036 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0049 0.0053
Trypanosoma brucei sugar transporter, putative 0.0031 0.0254 0.3381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0036 0.0048
Brugia malayi nuclear receptor NHR-88 0.0011 0.0036 0.0036
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0048 0.0064
Leishmania major glucose transporter/membrane transporter D2, putative 0.0068 0.0656 0.8747
Brugia malayi hypothetical protein 0.0012 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0048 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0048 0.0064
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.8747
Plasmodium falciparum calcium-dependent protein kinase 5 0.0067 0.0647 0.0647
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0048 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1979 0.6829
Trypanosoma brucei glucose transporter 1E 0.0068 0.0656 0.8747
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0254 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0588 0.0783
Brugia malayi Dopamine receptor protein 2 0.0012 0.0048 0.0051
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0048 0.0064
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2295 0.2562
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.0722
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0067 0.0647 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0049 0.017
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0136 0.0152
Entamoeba histolytica hypothetical protein 0.0049 0.045 0.1145
Loa Loa (eye worm) hypothetical protein 0.0038 0.0329 0.0427
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0121 0.2689
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0009 0.0012
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0067 0.0647 0.0976
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0329 0.7306
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Leishmania major lysyl-tRNA synthetase, putative 0.0049 0.045 0.5996
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0254 0.0875
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0036 0.0048
Echinococcus granulosus RUN 0.002 0.0136 0.0181
Onchocerca volvulus 0.0012 0.0048 0.0064
Brugia malayi Dopamine receptor protein 1 0.0012 0.0048 0.0051
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0122 0.4808
Schistosoma mansoni histamine h1 receptor 0.0012 0.0048 0.0064
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0048 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0397 0.137
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0329 0.438
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0036 0.0048
Brugia malayi Serotonin receptor 0.0012 0.0048 0.0051
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0121 0.2689
Echinococcus granulosus Smad4 0.0008 0.0009 0.0012
Echinococcus multilocularis solute carrier family 22 0.0031 0.0254 0.0283
Onchocerca volvulus 0.0012 0.0048 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni sugar transporter 0.0031 0.0254 0.0338
Toxoplasma gondii lysine-tRNA ligase 0.0049 0.045 0.0679
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1874 0.6466
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0048 0.0063
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0048 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0189 0.2544
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0048 0.0063
Brugia malayi beta-lactamase 0.0038 0.0329 0.0416
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0048 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0121 0.0416
Loa Loa (eye worm) hypothetical protein 0.0049 0.045 0.0585
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0656 0.8747
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0053 0.1186
Echinococcus granulosus chromobox protein 1 0.0073 0.0711 0.0947
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0254 0.033
Brugia malayi sulfakinin receptor protein 0.0012 0.0048 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0053 0.006
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0038 0.0504
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0619 0.0692
Schistosoma mansoni ap endonuclease 0.0019 0.0122 0.0162
Giardia lamblia Hexose transporter 0.0031 0.0254 0.0517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0412 0.0548
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0254 0.0283
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0048 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0049 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0036 0.0036
Echinococcus granulosus orexin receptor type 2 0.0012 0.0048 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0082 0.0284
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0049 0.0066
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.075 1
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.8747
Onchocerca volvulus 0.0012 0.0048 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0048 0.0054
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0067 0.009
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0048 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0656 0.2264
Mycobacterium ulcerans lipase LipD 0.0038 0.0329 0.7306
Schistosoma mansoni hypothetical protein 0.0012 0.0048 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.013
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.8747
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0049 0.0074
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0184
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0016 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0048 0.0064
Chlamydia trachomatis threonine--tRNA ligase 0.0012 0.0053 0.1186
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0711
Onchocerca volvulus 0.0032 0.0267 0.1258
Schistosoma mansoni hypothetical protein 0.0065 0.0619 0.0825
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni cpg binding protein 0.0031 0.0253 0.0336
Onchocerca volvulus 0.0031 0.0254 0.1183
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.033
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0048 0.0054
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.0125
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0656 0.8747
Brugia malayi neuropeptide F receptor 0.0012 0.0048 0.0051
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0656 0.2264
Echinococcus multilocularis Smad4 0.0008 0.0009 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.2899 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.2899 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0254 0.0319
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0329 0.438
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Brugia malayi SET domain containing protein 0.0013 0.0056 0.0061
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0009 0.001
Schistosoma mansoni coup transcription factor 0.0011 0.0036 0.0048
Leishmania major glucose transporter, lmgt2 0.0068 0.0656 0.8747
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1874 0.6466
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0064
Brugia malayi larval opioid receptor 0.0012 0.0048 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Echinococcus granulosus serotonin receptor 0.0012 0.0048 0.0064
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0254 0.5639
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0067 0.0647 0.0862
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0036 0.0048
Giardia lamblia DNA repair protein RAD52 0.037 0.393 1
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0656 0.2264
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0363 0.1779
Brugia malayi GnHR receptor homolog 0.0012 0.0048 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0647 0.0862
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0036 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0048 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Onchocerca volvulus 0.0031 0.0254 0.1183
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0048 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0036 0.0047
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0048 0.0051
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.037 0.393 1
Schistosoma mansoni hypothetical protein 0.014 0.1431 0.1906
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0254 0.0875
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0048 0.0064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0189 0.4202
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0177
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0048 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0048 0.0064
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.045 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0254 0.0865
Echinococcus multilocularis RUN 0.002 0.0136 0.0152
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.2899 1
Toxoplasma gondii protein kinase, putative 0.062 0.663 1
Plasmodium falciparum hexose transporter 0.0219 0.2295 0.2295
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Loa Loa (eye worm) hypothetical protein 0.014 0.1431 0.1862
Echinococcus granulosus solute carrier family 22 0.0031 0.0254 0.0338
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0329 0.1166
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0048 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0363 0.1253
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Schistosoma mansoni glucose transport protein 0.0219 0.2295 0.3056
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0048 0.0063
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0136 0.0181
Mycobacterium ulcerans hypothetical protein 0.0025 0.0189 0.4202
Echinococcus multilocularis calcium dependent protein kinase 0.0063 0.0602 0.0672
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0329 0.438
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0049 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0122 0.0421
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.4404 0.4918
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0254 0.0875
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0048 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0036 0.0041
Schistosoma mansoni hypothetical protein 0.0012 0.0049 0.0066
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0048 0.0063
Mycobacterium tuberculosis Conserved protein 0.0038 0.0329 0.1166
Mycobacterium ulcerans sugar transporter 0.0031 0.0254 0.5639

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1.02 nM Inhibition of the uterine smooth muscle contraction induced by histamine on the isolated rat uterus. ChEMBL. 6319701
ED50 (functional) = 52 nM Inhibition of the bronchospasm induced by histamine in guinea pig ChEMBL. 6319701

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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