Detailed information for compound 1078616

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.382 | Formula: C19H13FN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.49 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1cc(=O)oc2c1cccc2C)Nc1sc2c(n1)ccc(c2)F
  • InChi: 1S/C19H13FN2O3S/c1-10-3-2-4-13-11(8-17(24)25-18(10)13)7-16(23)22-19-21-14-6-5-12(20)9-15(14)26-19/h2-6,8-9H,7H2,1H3,(H,21,22,23)
  • InChiKey: DTLWPXPRPOPWRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0498 0.0495
Loa Loa (eye worm) hypothetical protein 0.0465 0.5303 0.7268
Onchocerca volvulus 0.0009 0.0036 0.0044
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0047 0.0472 0.4441
Echinococcus multilocularis protein C ets 2 0.0011 0.0056 0.0053
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0056 0.0053
Loa Loa (eye worm) globin family protein 0.0009 0.0036 0.0047
Schistosoma mansoni myoglobin 1 0.0009 0.0036 0.0072
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0129 0.0126
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.059 0.6741 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0126 0.0172
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.059 0.6741 1
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 2, putative 0.0006 0.0003 0.5
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0006 0.0003 0.0004
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0006 0.0003 0.0004
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0006 0.0003 0.0051
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0147 0.1625 0.3061
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0003
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.106 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0659 0.1364
Schistosoma mansoni ets 0.0011 0.0056 0.0114
Onchocerca volvulus 0.0009 0.0036 0.0044
Schistosoma mansoni hypothetical protein 0.0037 0.036 0.0746
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0056 0.0072
Plasmodium vivax ubiquitin specific protease, putative 0.0006 0.0003 0.5
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0019 0.003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0047
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.106 0.9782
Mycobacterium ulcerans lipoprotein LpqF 0.0066 0.0692 0.0979
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0056 0.0072
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.284 0.3892
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.106 0.1449
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0056 0.0053
Loa Loa (eye worm) fli-1 protein 0.0228 0.2559 0.3506
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0665 0.1377
Brugia malayi TAR-binding protein 0.0064 0.0665 0.0907
Echinococcus granulosus GPCR family 2 0.0017 0.0126 0.0232
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0126 0.0172
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Loa Loa (eye worm) hypothetical protein 0.0037 0.0353 0.0483
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.2454 0.336
Schistosoma mansoni cpg binding protein 0.0033 0.0316 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0214 0.1994
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0053
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0056 0.01
Schistosoma mansoni hypothetical protein 0.0011 0.0056 0.0114
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0056 0.0114
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0056 0.0114
Schistosoma mansoni Smad4 0.0008 0.0019 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0033
Schistosoma mansoni tsg101-related 0.0122 0.1342 0.2782
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0056 0.01
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0056 0.0053
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0832 0.0829
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0126 0.0232
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0259 0.2921 0.6058
Echinococcus granulosus cpg binding protein 0.0033 0.0316 0.0591
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0832 0.1723
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0056 0.0099
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0056 0.0072
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0182 0.203 0.3825
Loa Loa (eye worm) hypothetical protein 0.0218 0.2454 0.3362
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0056 0.0053
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0056 0.0053
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.106 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.036 0.0357
Loa Loa (eye worm) hypothetical protein 0.004 0.0389 0.0532
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0003 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0008 0.0047
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0056 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.106 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0056 0.0099
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0006 0.0003 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.036 0.0746
Echinococcus granulosus geminin 0.0175 0.1956 0.3685
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0056 0.01
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0353 0.048
Trypanosoma brucei polo-like protein kinase 0.0098 0.106 1
Brugia malayi hypothetical protein 0.0009 0.0036 0.0044
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.106 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0006 0.0003 0.0004
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0006 0.0003 0.0051
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0006 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0142 0.0193
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0126 0.0169
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0056 0.0114
Echinococcus multilocularis Kelch repeat type 1 0.0098 0.1063 0.106
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0056 0.0072
Echinococcus multilocularis GPCR, family 2 0.0017 0.0126 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Entamoeba histolytica hypothetical protein 0.0037 0.036 0.3308
Schistosoma mansoni hypothetical protein 0.0037 0.0353 0.0731
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0008 0.0047
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0832 0.1563
Echinococcus granulosus smad 0.0017 0.0129 0.0237
Brugia malayi hypothetical protein 0.0009 0.0036 0.0044
Schistosoma mansoni cpg binding protein 0.003 0.0274 0.0566
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Onchocerca volvulus 0.0009 0.0036 0.0044
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0832 0.1723
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0832 0.0829
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0006 0.0003 0.0004
Brugia malayi nuclear hormone receptor 0.0011 0.0056 0.0072
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0056 0.0114
Echinococcus multilocularis muscleblind protein 1 0.0465 0.5303 0.5302
Echinococcus granulosus kelch ECH associated protein 1 like 0.0098 0.1059 0.1993
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0147 0.1625 0.1623
Schistosoma mansoni peptidase 0.0007 0.0007 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0056 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0498 0.1032
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0832 0.7671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0498 0.0934
Schistosoma mansoni ets-related 0.0228 0.2559 0.5307
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0137 0.1517 0.2209
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0665 0.091
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0832 0.7842
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0056 0.0072
Echinococcus multilocularis smad 0.0017 0.0129 0.0126
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0664 0.0661
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0549 0.0752
Brugia malayi Globin family protein 0.0009 0.0036 0.0044
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0134 0.0131
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0016 0.0013
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0056 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0019 0.0025
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0832 0.1563
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0056 0.0072
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0006 0.0003 0.0004
Echinococcus multilocularis kelch ECH associated protein 1 0.0098 0.1059 0.1057
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0832 0.7842
Echinococcus multilocularis Smad4 0.0017 0.0129 0.0126
Onchocerca volvulus 0.0011 0.0056 0.0072
Brugia malayi Ets-domain containing protein 0.0011 0.0056 0.0072
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0056 0.0075
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0832 0.1563
Entamoeba histolytica hypothetical protein 0.0037 0.036 0.3308
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Toxoplasma gondii hypothetical protein 0.0006 0.0003 0.0051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0549 0.0749
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0056 0.0075
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0056 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0056 0.0072
Echinococcus granulosus kelch ECH associated protein 1 0.0098 0.1059 0.1993
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Brugia malayi CXXC zinc finger family protein 0.003 0.0274 0.0371
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0056 0.0072
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0219 0.0216
Schistosoma mansoni smad 0.0017 0.0129 0.0265
Brugia malayi hypothetical protein 0.0009 0.0036 0.0044
Brugia malayi MH1 domain containing protein 0.0017 0.0129 0.0172
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0056 0.0072
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0056 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Brugia malayi RNA binding protein 0.0064 0.0665 0.0907
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0498 0.1032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 1, putative 0.0006 0.0003 0.5
Echinococcus granulosus tar DNA binding protein 0.0064 0.0665 0.1248
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0134 0.0247
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0056 0.0075
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0274 0.0374
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0056 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0056 0.0099
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0003 0.5
Echinococcus multilocularis zinc finger protein 0.0022 0.0184 0.0181
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Schistosoma mansoni elf1 0.0011 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0832 0.7842
Entamoeba histolytica hypothetical protein 0.0025 0.0214 0.1951
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0003 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0008 0.0047
Schistosoma mansoni calpain-7 (C02 family) 0.0006 0.0003 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0063
Schistosoma mansoni hypothetical protein 0.0175 0.1956 0.4057
Plasmodium vivax hypothetical protein, conserved 0.0006 0.0003 0.5
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Schistosoma mansoni smad1 5 8 and 0.0017 0.0129 0.0265
Schistosoma mansoni hypothetical protein 0.0006 0.0003 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0013
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Brugia malayi PHD-finger family protein 0.0027 0.0248 0.0335
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0142 0.0292
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0006 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0078 0.0832 0.1139
Echinococcus multilocularis ets variant gene 4 0.0011 0.0056 0.0053
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.059 0.6741 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0609 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0008 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0056 0.0075
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0056 0.0114
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0056 0.0099
Plasmodium falciparum ubiquitin specific protease, putative 0.0006 0.0003 0.5
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0129 0.0237
Trypanosoma cruzi ISWI complex protein 0.0016 0.0113 0.1042
Brugia malayi hypothetical protein 0.0037 0.036 0.049
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0056 0.0072
Schistosoma mansoni hypothetical protein 0.0423 0.4821 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0003
Schistosoma mansoni Smad4 0.0008 0.0019 0.0037
Entamoeba histolytica hypothetical protein 0.0025 0.0214 0.1951
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.0025
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0056 0.0053
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0047
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.106 0.1994
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 2, putative 0.0006 0.0003 0.5
Entamoeba histolytica hypothetical protein 0.0037 0.036 0.3308
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.106 1
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0066 0.0692 0.0979
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Schistosoma mansoni bromodomain containing protein 0.0067 0.0706 0.1464
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0134 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0498 0.1032
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0056 0.0114
Schistosoma mansoni cpg binding protein 0.0033 0.0316 0.0654
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0006 0.0003 0.5
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase family 2 protein 0.0006 0.0003 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0056 0.0072
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0019 0.0022
Echinococcus multilocularis cpg binding protein 0.0033 0.0316 0.0313
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0214 0.1994
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Brugia malayi MH1 domain containing protein 0.0009 0.004 0.0051
Schistosoma mansoni hypothetical protein 0.0175 0.1956 0.4057
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0016 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.106 0.2197
Schistosoma mansoni smad1 5 8 and 0.0017 0.0129 0.0265
Onchocerca volvulus 0.003 0.0274 0.0371
Loa Loa (eye worm) hypothetical protein 0.0638 0.7297 1
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0006 0.0003 0.0004
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0078 0.0832 0.7842
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0498 0.0679
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0024
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0142 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0489 0.4602
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0008 0.0047
Echinococcus granulosus kelch ECH associated protein 1 like 0.0098 0.1059 0.1993
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0008 0.0047
Schistosoma mansoni hypothetical protein 0.0017 0.0126 0.026
Loa Loa (eye worm) hypothetical protein 0.0064 0.0671 0.0918
Schistosoma mansoni hypothetical protein 0.0011 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0665 0.0907
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0489 0.4602
Brugia malayi Fli-1 protein 0.0228 0.2559 0.3504
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0075
Schistosoma mansoni hypothetical protein 0.0009 0.0036 0.0072
Leishmania major hypothetical protein, conserved 0.0016 0.0113 0.1042
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.036 0.0674
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0417 0.0571
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0006 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0056 0.0075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0126 0.0123
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0129 0.0237
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0498 0.0682
Brugia malayi MH2 domain containing protein 0.0017 0.0129 0.0172
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0006 0.0003 0.0004
Onchocerca volvulus 0.0009 0.0036 0.0044
Brugia malayi steroid hormone receptor 0.0011 0.0056 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0142 0.0292
Trypanosoma cruzi ISWI complex protein 0.0016 0.0113 0.1042
Schistosoma mansoni coup transcription factor 0.0011 0.0056 0.0114
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0006 0.0003 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0142 0.0262
Loa Loa (eye worm) RNA binding protein 0.0064 0.0665 0.091
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0056 0.0053
Echinococcus granulosus muscleblind protein 0.0465 0.5303 1
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.01 0.1083 1
Loa Loa (eye worm) Smad1 0.0017 0.0129 0.0175
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0056 0.0114
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0832 0.7842
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0006 0.0003 0.5
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0056 0.0075
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0056 0.0072
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0056 0.01
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0182 0.203 0.2028
Loa Loa (eye worm) hypothetical protein 0.0046 0.046 0.0629
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0056 0.0114
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Schistosoma mansoni zinc finger protein 0.0016 0.0113 0.0233
Loa Loa (eye worm) nuclear factor I 0.0009 0.004 0.0053
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0219 0.0408
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0665 0.1377
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0219 0.0453
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0008 0.0047
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0006 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0126 0.0169
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi Bromodomain containing protein 0.0079 0.0847 0.1156
Schistosoma mansoni tsg101-related 0.01 0.1083 0.2245
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.036 0.0357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0056 0.0075
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0832 0.7842
Schistosoma mansoni ets-related 0.0011 0.0056 0.0114
Schistosoma mansoni Smad4 0.0017 0.0129 0.0265
Schistosoma mansoni hypothetical protein 0.0016 0.0113 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0056 0.0075
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0796 0.109
Brugia malayi nuclear receptor NHR-88 0.0011 0.0056 0.0072
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.036 0.0673
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.106 0.1449
Entamoeba histolytica hypothetical protein 0.0025 0.0214 0.1951
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.284 0.3892
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0003 0.5
Leishmania major adenylate cyclase-like protein 0.0009 0.0036 0.0307
Echinococcus granulosus zinc finger protein 0.0022 0.0184 0.0341
Toxoplasma gondii ubiquitin-specific protease USP4 0.0006 0.0003 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0056 0.0075
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0129 0.0126
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0134 0.0276
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Trypanosoma brucei beta lactamase 0.0066 0.0692 0.6519
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Schistosoma mansoni gabp alpha 0.0075 0.0796 0.165
Brugia malayi Muscleblind-like protein 0.0465 0.5303 0.7267
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0259 0.2921 0.2919
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0832 0.7842
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0832 0.1136
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0019 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0008 0.0047
Entamoeba histolytica hypothetical protein 0.0025 0.0214 0.1951
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0498 0.0495
Schistosoma mansoni zinc finger protein 0.0022 0.0184 0.038
Schistosoma mansoni smad1 5 8 and 0.0017 0.0129 0.0265
Schistosoma mansoni tsg101-related 0.0122 0.1342 0.2782
Trypanosoma brucei ISWI complex protein 0.0016 0.0113 0.1042
Brugia malayi ecdysteroid receptor 0.0011 0.0056 0.0072
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Brugia malayi transcription factor E74 isoform 0.0011 0.0056 0.0072
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0056 0.0099
Brugia malayi MH2 domain containing protein 0.0252 0.284 0.389
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0665 0.1377
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0137 0.1517 0.2209
Leishmania major hypothetical protein, conserved 0.0047 0.0472 0.4441
Brugia malayi Hypothetical 22.2 kDa protein C28F5.2 in chromosome II, putative 0.0009 0.0036 0.0044
Brugia malayi MH1 domain containing protein 0.0009 0.004 0.0051
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0019 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0056 0.0053
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0832 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0056 0.0072
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0056 0.0072
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0056 0.01
Brugia malayi Globin family protein 0.0009 0.0036 0.0044
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.106 0.1451
Onchocerca volvulus 0.0638 0.7297 1
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0832 0.7842
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0142 0.0139
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0006 0.0003 0.0004
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 14 0.0006 0.0003 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0177 0.0241
Trichomonas vaginalis helicase, putative 0.0007 0.0008 0.0047
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0129 0.0175
Brugia malayi Ets-domain containing protein 0.0075 0.0796 0.1087
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047
Echinococcus multilocularis muscleblind protein 0.0465 0.5303 0.5302
Onchocerca volvulus Globin homolog 0.0009 0.0036 0.0044
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0056 0.0099
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0058 0.0075
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0214 0.1994
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0129 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0214 0.1994
Loa Loa (eye worm) globin family protein 0.0009 0.0036 0.0047
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.4821 0.4819
Schistosoma mansoni hypothetical protein 0.0017 0.0126 0.026
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase family 2, putative 0.0006 0.0003 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0056 0.0072
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0056 0.0053
Brugia malayi hypothetical protein 0.0009 0.0036 0.0044
Schistosoma mansoni hypothetical protein 0.0021 0.0177 0.0365
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0006 0.0003 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.106 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.106 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0664 0.1246
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0665 0.1377
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0259 0.2921 0.5505
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0665 0.1377
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.106 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0056 0.0075
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0006 0.0003 0.0004
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0006 0.0003 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0423 0.4821 0.909
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0056 0.0114
Brugia malayi Bromodomain containing protein 0.004 0.0388 0.0528
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0051
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0665 0.0662
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0047 0.0472 0.4441
Schistosoma mansoni kinase 0.005 0.0504 0.1044
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0056 0.0053
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0006 0.0003 0.0004
Brugia malayi Globin family protein 0.0009 0.0036 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0056 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0214 0.1994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0056 0.0072
Echinococcus multilocularis kelch ECH associated protein 1 0.0098 0.1059 0.1057
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Schistosoma mansoni calpain-7 (C02 family) 0.0006 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0073 0.0776 0.1062
Plasmodium falciparum ubiquitin specific protease, putative 0.0006 0.0003 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047
Brugia malayi MH2 domain containing protein 0.0017 0.0129 0.0172
Brugia malayi Ets-domain containing protein 0.0075 0.0796 0.1087
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0056 0.0053
Onchocerca volvulus 0.0009 0.0036 0.0044
Schistosoma mansoni hypothetical protein 0.0017 0.0126 0.026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0129 0.0265
Echinococcus granulosus protein C ets 2 0.0011 0.0056 0.01
Schistosoma mansoni hypothetical protein 0.0017 0.0126 0.026
Brugia malayi MH2 domain containing protein 0.0008 0.0019 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0056 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0056 0.0072
Giardia lamblia Kinase, PLK 0.0098 0.106 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0056 0.0053
Schistosoma mansoni globin X 0.0009 0.0036 0.0072
Loa Loa (eye worm) hypothetical protein 0.0147 0.1625 0.2226
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0056 0.0053
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0056 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.106 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0019 0.0025
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0056 0.0072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0047
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0056 0.0114
Brugia malayi hypothetical protein 0.0147 0.1625 0.2224
Brugia malayi Smad1 0.0017 0.0129 0.0172
Brugia malayi hypothetical protein 0.0638 0.7297 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0498 0.0934
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0006 0.0003 0.0004
Entamoeba histolytica hypothetical protein 0.0037 0.036 0.3308
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0796 0.1496
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0665 0.091
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0796 0.0793
Echinococcus multilocularis geminin 0.0175 0.1956 0.1954
Loa Loa (eye worm) hypothetical protein 0.0465 0.5303 0.7268
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0006 0.0003 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0056 0.0075
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0006 0.0003 0.5
Schistosoma mansoni hypothetical protein 0.0098 0.1063 0.2203
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0056 0.0114
Brugia malayi MH1 domain containing protein 0.0017 0.0129 0.0172
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.106 0.1057
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0006 0.0003 0.0004
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0006 0.0003 0.0004
Echinococcus granulosus Smad4 0.0017 0.0129 0.0237
Trichomonas vaginalis hypothetical protein 0.0071 0.0756 0.7125
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0037 0.0049
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Schistosoma mansoni smad 0.0008 0.0019 0.0037
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0019 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.106 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0016 0.003
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0008 0.0047

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 100 ug ml-1 Cytotoxicity against human mock-infected MT4 cells after 4 days by MTT assay ChEMBL. 21515046

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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