Detailed information for compound 1085081

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 381.511 | Formula: C23H31N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1C)CN1CCC[C@H](CC1)NC(=O)c1cncc(c1)C
  • InChi: 1S/C23H31N3O2/c1-4-28-22-13-19(8-7-18(22)3)16-26-10-5-6-21(9-11-26)25-23(27)20-12-17(2)14-24-15-20/h7-8,12-15,21H,4-6,9-11,16H2,1-3H3,(H,25,27)/t21-/m1/s1
  • InChiKey: IWMGBKBZSBHXDP-OAQYLSRUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens somatostatin receptor 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor somatostatin receptor 5 364 aa 392 aa 19.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0214 0.0522
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Onchocerca volvulus 0.0024 0.0036 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.004
Echinococcus multilocularis peregrin 0.012 0.0618 0.0618
Plasmodium vivax lactate dehydrogenase 0.0069 0.0309 0.4995
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0027 0.0052 0.0119
Echinococcus granulosus integrin alpha 3 0.0069 0.0309 0.0752
Loa Loa (eye worm) hypothetical protein 0.0054 0.0214 0.0675
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0036 0.0087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0332 0.1909 0.6014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0332 0.1909 0.1909
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.0678
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0101 0.0505 0.1192
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0127 0.0399
Echinococcus multilocularis tar DNA binding protein 0.0193 0.1062 0.1062
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0036 0.0113
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0036 0.0036
Toxoplasma gondii lactate dehydrogenase LDH2 0.0069 0.0309 0.4995
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0713 0.4228 1
Plasmodium falciparum phd finger protein, putative 0.012 0.0618 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0127 0.2053
Loa Loa (eye worm) hypothetical protein 0.0299 0.1709 0.5383
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0013 0.0031
Entamoeba histolytica hypothetical protein 0.0036 0.0105 0.3366
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0036
Giardia lamblia Malate dehydrogenase 0.0027 0.0052 0.0814
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0713 0.4228 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0127 0.0309
Schistosoma mansoni thyroid hormone receptor 0.002 0.0013 0.0031
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0088
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0013 0.0031
Echinococcus multilocularis integrin alpha 3 0.0069 0.0309 0.0309
Schistosoma mansoni tar DNA-binding protein 0.0193 0.1062 0.2585
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0002 0.0005
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0099 0.16
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0099 0.7978
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0013 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.2045 0.4834
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0105 0.0255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0332 0.1909 0.1909
Giardia lamblia PHD finger protein 15 0.012 0.0618 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0013 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0052 0.0837
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0013 0.0013
Echinococcus granulosus lactate dehydrogenase a 0.0069 0.0309 0.0751
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Echinococcus multilocularis L lactate dehydrogenase 0.0042 0.0145 0.0145
Schistosoma mansoni jumonji domain containing protein 0.0039 0.0124 0.0302
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.026 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0013 0.004
Onchocerca volvulus 0.002 0.0013 0.0047
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0068 0.0303 0.0956
Schistosoma mansoni integrin alpha 0.009 0.0437 0.1064
Loa Loa (eye worm) malate dehydrogenase 0.0027 0.0052 0.0163
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0013 0.0013
Echinococcus multilocularis malate dehydrogenase 0.0027 0.0052 0.0052
Toxoplasma gondii exonuclease III APE 0.0019 0.0002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0069 0.0309 0.0972
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0101 0.0505 1
Mycobacterium ulcerans L-lysine aminotransferase 0.0101 0.0505 0.1192
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Echinococcus granulosus ornithine aminotransferase 0.0101 0.0505 0.1231
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0069 0.0309 0.6092
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0099 0.16
Schistosoma mansoni hypothetical protein 0.0034 0.0095 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.054 0.3175 0.7508
Brugia malayi Pax transcription factor protein 2 0.0116 0.0595 0.1875
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0214 0.0214
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Loa Loa (eye worm) Smad1 0.0024 0.0036 0.0113
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Echinococcus multilocularis lysine specific demethylase 6a 0.0039 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0039 0.0124 0.039
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0027 0.0052 0.0052
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0013 0.0013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0002 0.0002
Plasmodium falciparum malate dehydrogenase 0.0069 0.0309 0.4995
Brugia malayi AF-10 protein 0.0039 0.0127 0.0399
Brugia malayi jmjC domain containing protein 0.0039 0.0124 0.039
Trypanosoma cruzi malate dehydrogenase, putative 0.0027 0.0052 0.418
Echinococcus multilocularis lactate dehydrogenase protein 0.0069 0.0309 0.0309
Toxoplasma gondii PHD-finger domain-containing protein 0.012 0.0618 1
Brugia malayi Kelch motif family protein 0.0028 0.0059 0.0186
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0088
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0127 1
Schistosoma mansoni jumonji domain containing protein 0.0312 0.1786 0.4348
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.2045 0.4834
Entamoeba histolytica hypothetical protein 0.0036 0.0105 0.3366
Schistosoma mansoni coup transcription factor 0.002 0.0013 0.0031
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0214 0.0794
Schistosoma mansoni integrin alpha-ps 0.0021 0.0017 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0013 0.0013
Mycobacterium ulcerans malate dehydrogenase 0.0027 0.0052 0.0119
Echinococcus granulosus jumonji domain containing protein 0.0167 0.0903 0.2199
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0013 0.004
Schistosoma mansoni transcription factor btf3 0.0035 0.0099 0.0241
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0114
Brugia malayi TAR-binding protein 0.0193 0.1062 0.3344
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0052 0.0837
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0713 0.4228 1
Brugia malayi MH1 domain containing protein 0.0024 0.0036 0.0113
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0013 0.0013
Echinococcus multilocularis transcription factor btf3 0.0035 0.0099 0.0099
Echinococcus multilocularis malate dehydrogenase 0.0027 0.0052 0.0052
Echinococcus multilocularis Smad4 0.0024 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0114
Echinococcus granulosus FTZ F1 alpha 0.002 0.0013 0.0031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0013 0.0031
Brugia malayi Integrin beta pat-3 precursor 0.0185 0.1012 0.3187
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0114
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0214 0.0522
Trichomonas vaginalis glucosylceramidase, putative 0.054 0.3175 0.7508
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0101 0.0505 0.1592
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0194 0.1068 0.3953
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0101 0.0505 0.1192
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.2161 0.5109
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Loa Loa (eye worm) hypothetical protein 0.0037 0.0112 0.0352
Echinococcus granulosus L lactate dehydrogenase B chain 0.0069 0.0309 0.0751
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0036 0.0113
Brugia malayi Trypsin family protein 0.0024 0.0036 0.0114
Echinococcus multilocularis glycoprotein Antigen 5 0.0024 0.0036 0.0036
Brugia malayi N-terminal motif family protein 0.0194 0.1068 0.3363
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0039 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.002
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.1196 0.1196
Onchocerca volvulus 0.0024 0.0036 0.0134
Schistosoma mansoni integrin beta subunit 0.0109 0.055 0.1339
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0002 0.0053
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0088
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0039 0.0124 0.9763
Schistosoma mansoni smad1 5 8 and 0.0024 0.0036 0.0087
Brugia malayi MH1 domain containing protein 0.0024 0.0036 0.0113
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0002 0.0026
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0027 0.0052 0.0119
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0004
Onchocerca volvulus 0.0024 0.0036 0.0134
Trypanosoma brucei malate dehydrogenase-related 0.0027 0.0052 0.4005
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0101 0.0505 0.1192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0332 0.1909 0.4649
Echinococcus multilocularis lactate dehydrogenase a 0.0069 0.0309 0.0309
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0027 0.0052 0.418
Mycobacterium ulcerans acetylornithine aminotransferase 0.0101 0.0505 0.1192
Loa Loa (eye worm) hypothetical protein 0.0061 0.026 0.0817
Echinococcus granulosus Smad4 0.0024 0.0036 0.0087
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0099 0.16
Brugia malayi steroid hormone receptor 0.002 0.0013 0.004
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0088
Echinococcus multilocularis lactate dehydrogenase a 0.0069 0.0309 0.0309
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.026 0.026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0013 0.0031
Loa Loa (eye worm) RNA binding protein 0.0193 0.1062 0.3344
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0332 0.1909 0.6014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0215 0.0678
Entamoeba histolytica hypothetical protein 0.0035 0.0099 0.3167
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0124 0.0124
Echinococcus multilocularis PHD finger protein rhinoceros 0.012 0.0618 0.0618
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0214 0.0522
Brugia malayi Smad1 0.0024 0.0036 0.0113
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0214 0.0522
Echinococcus granulosus phd:f box containing protein 0.0039 0.0124 0.0302
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0013 0.0031
Plasmodium falciparum L-lactate dehydrogenase 0.0069 0.0309 0.4995
Entamoeba histolytica hypothetical protein 0.0036 0.0105 0.3366
Leishmania major basic transcription factor 3a, putative 0.0035 0.0099 0.3203
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0101 0.0505 0.1192
Leishmania major malate dehydrogenase 0.0027 0.0052 0.1678
Brugia malayi Trypsin-like protease protein 5 0.0024 0.0036 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0112 0.0352
Echinococcus granulosus transcription factor btf3 0.0035 0.0099 0.0241
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0036 0.0087
Echinococcus multilocularis integrin alpha ps 0.0019 0.0006 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0013 0.004
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0101 0.0505 0.1086
Echinococcus granulosus glycoprotein Antigen 5 0.0024 0.0036 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0013 0.004
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0069 0.0309 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0013 0.004
Schistosoma mansoni phosphatidylserine receptor 0.0039 0.0124 0.0302
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Leishmania major hypothetical protein, conserved 0.0039 0.0124 0.4014
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.012 0.0618 0.1504
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.1196 0.2911
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0039 0.0124 0.2005
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0027 0.0052 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.2045 0.4834
Entamoeba histolytica malate dehydrogenase, putative 0.0069 0.0309 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.0901 0.2839
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0052 0.0837
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0002 0.0131
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0101 0.0505 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0618 0.1946
Brugia malayi mbt repeat family protein 0.0054 0.0214 0.0675
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0101 0.0505 0.1086
Echinococcus granulosus L lactate dehydrogenase 0.0042 0.0145 0.0354
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0013 0.0031
Onchocerca volvulus 0.0299 0.1709 0.6327
Onchocerca volvulus Glucosylceramidase homolog 0.0354 0.2045 0.757
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0099 0.3167
Schistosoma mansoni hypothetical protein 0.0037 0.0112 0.0272
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0027 0.0052 0.418
Trichomonas vaginalis glucosylceramidase, putative 0.054 0.3175 0.7508
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0052 0.0837
Echinococcus multilocularis phd:f box containing protein 0.0039 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.0039 0.0127 0.0309
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0332 0.1909 0.4649
Brugia malayi RNA recognition motif domain containing protein 0.0193 0.1062 0.3344
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0036 0.0087
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0027 0.0052 0.1634
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0027 0.0052 0.418
Echinococcus granulosus Mastin 0.0024 0.0036 0.0088
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0299 0.1709 0.4161
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0299 0.1709 0.4161
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0002 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0013 0.004
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0004
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0101 0.0505 0.1192
Schistosoma mansoni survival motor neuron protein 0.0034 0.0095 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0099 0.023
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0027 0.0052 0.0163
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0013 0.0031
Brugia malayi jmjC domain containing protein 0.0145 0.0771 0.2429
Brugia malayi PHD-finger family protein 0.012 0.0618 0.1946
Loa Loa (eye worm) hypothetical protein 0.0071 0.0319 0.1005
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0101 0.0505 0.1192
Echinococcus multilocularis lysine specific demethylase 5A 0.0145 0.0771 0.0771
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.026 0.0817
Schistosoma mansoni integrin alpha-ps 0.004 0.0134 0.0327
Echinococcus granulosus survival motor neuron protein 1 0.0166 0.0901 0.2194
Loa Loa (eye worm) malate dehydrogenase 0.0027 0.0052 0.0163
Loa Loa (eye worm) PHD-finger family protein 0.012 0.0618 0.1946
Toxoplasma gondii lactate dehydrogenase LDH1 0.0069 0.0309 0.4995
Schistosoma mansoni L-lactate dehydrogenase 0.0069 0.0309 0.0751
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0186
Echinococcus multilocularis enteropeptidase 0.0024 0.0036 0.0036
Schistosoma mansoni malate dehydrogenase 0.0027 0.0052 0.0126
Echinococcus granulosus integrin alpha ps 0.0019 0.0006 0.0015
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0099 0.7978
Schistosoma mansoni tar DNA-binding protein 0.0193 0.1062 0.2585
Schistosoma mansoni tar DNA-binding protein 0.0193 0.1062 0.2585
Echinococcus granulosus cytosolic malate dehydrogenase 0.0027 0.0052 0.0126
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0013 0.0047
Mycobacterium tuberculosis Probable aminotransferase 0.0713 0.4228 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0052 0.3998
Schistosoma mansoni smad1 5 8 and 0.0024 0.0036 0.0087
Schistosoma mansoni jumonji/arid domain-containing protein 0.0145 0.0771 0.1878
Echinococcus granulosus lysine specific demethylase 5A 0.0145 0.0771 0.1878
Brugia malayi hypothetical protein 0.0024 0.0036 0.0114
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0027 0.0052 0.418
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0013 0.004
Brugia malayi Integrin alpha pat-2 precursor 0.009 0.0437 0.1376
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0105 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0013 0.004
Echinococcus multilocularis geminin 0.0693 0.4107 0.4107
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0013 0.004
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0024 0.0036 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0193 0.1062 0.2585
Plasmodium vivax malate dehydrogenase, putative 0.0069 0.0309 0.4995
Toxoplasma gondii PHD-finger domain-containing protein 0.012 0.0618 1
Schistosoma mansoni hypothetical protein 0.0036 0.0105 0.0255
Schistosoma mansoni jumonji/arid domain-containing protein 0.0145 0.0771 0.1878
Schistosoma mansoni nuclear hormone receptor 0.002 0.0013 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0052 0.4172
Onchocerca volvulus 0.0054 0.0214 0.0794
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0114
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0101 0.0505 0.1192
Trichomonas vaginalis glucosylceramidase, putative 0.054 0.3175 0.7508
Onchocerca volvulus 0.0116 0.0595 0.2204
Schistosoma mansoni malate dehydrogenase 0.0027 0.0052 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0013 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0332 0.1909 0.4649
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0013 0.004
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0013 0.004
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0002 0.0005
Echinococcus granulosus malate dehydrogenase 0.0027 0.0052 0.0126
Leishmania major cytosolic malate dehydrogenase 0.0027 0.0052 0.1678
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Echinococcus granulosus malate dehydrogenase 0.0027 0.0052 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0124 0.039
Brugia malayi nuclear hormone receptor 0.002 0.0013 0.004
Schistosoma mansoni malate dehydrogenase 0.0027 0.0052 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0013 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0013 0.0031
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0392 0.2277 0.2277
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0127 0.2053
Trichomonas vaginalis glucosylceramidase, putative 0.054 0.3175 0.7508
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0052 0.4172
Loa Loa (eye worm) integrin beta-2 0.0185 0.1012 0.3187
Loa Loa (eye worm) jmjC domain-containing protein 0.0247 0.1394 0.4391
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.2045 0.4834
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0013 0.0031
Brugia malayi lactate dehydrogenase. 0.0069 0.0309 0.0972
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0013 0.0013
Echinococcus multilocularis survival motor neuron protein 1 0.0166 0.0901 0.0901
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0713 0.4228 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0013 0.004
Echinococcus granulosus lactate dehydrogenase a 0.0069 0.0309 0.0751
Loa Loa (eye worm) hypothetical protein 0.0039 0.0124 0.039
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.2045 0.4834
Plasmodium falciparum lactate dehydrogenase, putative 0.0027 0.0052 0.0838
Onchocerca volvulus 0.0034 0.0095 0.0352
Brugia malayi Trypsin family protein 0.0024 0.0036 0.0114
Entamoeba histolytica hypothetical protein 0.0036 0.0105 0.3366
Plasmodium falciparum JmjC domain-containing protein, putative 0.0039 0.0124 0.2005
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.2161 0.5109
Echinococcus granulosus peregrin 0.012 0.0618 0.1504
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0002 0.0026
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0099 0.7763
Schistosoma mansoni malate dehydrogenase 0.0069 0.0309 0.0751
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0027 0.0052 0.0119
Brugia malayi jmjC domain containing protein 0.0039 0.0124 0.039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0215 0.0678
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0183 0.1001 0.1001
Leishmania major malate dehydrogenase, putative 0.0027 0.0052 0.1678
Schistosoma mansoni Smad4 0.0024 0.0036 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0114
Trypanosoma brucei cytosolic malate dehydrogenase 0.0027 0.0052 0.4005
Loa Loa (eye worm) hypothetical protein 0.0194 0.1068 0.3363
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0002 0.0004
Brugia malayi Trypsin family protein 0.0299 0.1709 0.5383
Brugia malayi nuclear receptor NHR-88 0.002 0.0013 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0013 0.0047
Plasmodium vivax hypothetical protein, conserved 0.012 0.0618 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0013 0.0031
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0039 0.0127 0.2053
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.026 0.0632
Echinococcus multilocularis smad 0.0024 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0462 0.2701 0.8508
Echinococcus multilocularis JmjC domain containing protein 4 0.0039 0.0124 0.0124
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0027 0.0052 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0013 0.004
Schistosoma mansoni hypothetical protein 0.0693 0.4107 1
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.2051 0.6461
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0013 0.0047
Echinococcus granulosus integrin alpha ps 0.004 0.0134 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0013 0.004
Brugia malayi beta-NAC-like protein 0.0035 0.0099 0.0311
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0127 0.2053
Brugia malayi mbt repeat family protein 0.0054 0.0214 0.0675
Echinococcus granulosus Aminotransferase class III 0.0101 0.0505 0.1231
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.004
Schistosoma mansoni hypothetical protein 0.0693 0.4107 1
Leishmania major glycosomal malate dehydrogenase 0.0027 0.0052 0.1678
Leishmania major malate dehydrogenase, putative 0.0069 0.0309 1
Schistosoma mansoni hypothetical protein 0.0329 0.1893 0.4608
Schistosoma mansoni phd/f-box containing protein 0.0039 0.0124 0.0302
Schistosoma mansoni retinoic acid receptor RXR 0.0194 0.1067 0.2597
Loa Loa (eye worm) hypothetical protein 0.005 0.0191 0.0602
Loa Loa (eye worm) hypothetical protein 0.0299 0.1709 0.5383
Echinococcus multilocularis ornithine aminotransferase 0.0101 0.0505 0.0505
Schistosoma mansoni smad1 5 8 and 0.0024 0.0036 0.0087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0193 0.1062 0.3344
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0013 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0052
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0101 0.0505 0.1231
Entamoeba histolytica malate dehydrogenase, putative 0.0027 0.0052 0.1634
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0099 0.0311
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0105 0.0105
Trypanosoma brucei glycosomal malate dehydrogenase 0.0027 0.0052 0.4005
Brugia malayi MH2 domain containing protein 0.0355 0.2051 0.6461
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0013 0.0031
Echinococcus multilocularis fibrillin 1 0.002 0.0009 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0013 0.004
Brugia malayi MH2 domain containing protein 0.0024 0.0036 0.0113
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0024 0.0036 0.0036
Brugia malayi hypothetical protein 0.0166 0.0901 0.2839
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.004
Brugia malayi jmjC domain containing protein 0.0039 0.0124 0.039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0332 0.1909 0.4649
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.2045 0.4834
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0214 0.0675
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.2045 0.4834
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.004
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0039 0.0124 0.2005
Leishmania major mitochondrial malate dehydrogenase 0.0027 0.0052 0.1678
Toxoplasma gondii malate dehydrogenase MDH 0.0069 0.0309 0.4995
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.026 0.0632
Loa Loa (eye worm) hypothetical protein 0.0205 0.1139 0.3587
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0214 0.0214
Echinococcus granulosus lactate dehydrogenase protein 0.0069 0.0309 0.0751
Leishmania major hypothetical protein, conserved 0.0027 0.0052 0.1675
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0039 0.0124 1
Schistosoma mansoni tar DNA-binding protein 0.0193 0.1062 0.2585
Mycobacterium ulcerans hypothetical protein 0.0024 0.0036 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0013 0.004
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0088
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.026 0.0632
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0039 0.0124 0.0302
Echinococcus multilocularis jumonji domain containing protein 0.0167 0.0903 0.0903
Brugia malayi jmjC domain containing protein 0.0392 0.2277 0.7172
Brugia malayi hypothetical protein 0.0028 0.0059 0.0186
Loa Loa (eye worm) trypsin family protein 0.0024 0.0036 0.0114
Echinococcus multilocularis integrin alpha ps 0.004 0.0134 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0013 0.004
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0027 0.0052 0.418
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0013 0.004
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Echinococcus multilocularis jumonji domain containing 1A 0.0039 0.0124 0.0124
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0024 0.0036 0.0114
Brugia malayi PHD-finger family protein 0.0039 0.0127 0.0399
Brugia malayi jmjC domain containing protein 0.0039 0.0124 0.039
Brugia malayi MH2 domain containing protein 0.0024 0.0036 0.0113
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0027 0.0052 0.4005
Plasmodium falciparum ornithine aminotransferase 0.0101 0.0505 0.8182
Echinococcus multilocularis ornithine aminotransferase 0.0101 0.0505 0.0505
Brugia malayi RNA binding protein 0.0193 0.1062 0.3344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0332 0.1909 0.4649
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0024 0.0036 0.0088
Onchocerca volvulus 0.0024 0.0036 0.0134
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0101 0.0505 0.8182
Loa Loa (eye worm) MBCTL1 0.0061 0.026 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0099 0.023
Onchocerca volvulus 0.0462 0.2701 1
Schistosoma mansoni protein phosphatase 2C 0.0039 0.0124 0.0302
Echinococcus granulosus geminin 0.0693 0.4107 1
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0101 0.0505 0.1086
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0028 0.0059 0.0186
Loa Loa (eye worm) jmjC domain-containing protein 0.0145 0.0771 0.2429
Echinococcus granulosus tar DNA binding protein 0.0193 0.1062 0.2585
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0013 0.004
Onchocerca volvulus 0.0275 0.1561 0.578
Trichomonas vaginalis glucosylceramidase, putative 0.054 0.3175 0.7508
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0013 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0124 0.039
Mycobacterium ulcerans hypothetical protein 0.0713 0.4228 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0034 0.0095 0.0299
Onchocerca volvulus 0.0024 0.0036 0.0134
Loa Loa (eye worm) integrin alpha pat-2 0.0139 0.0734 0.2312
Echinococcus multilocularis Aminotransferase class III 0.0101 0.0505 0.0505
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.0036 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0013 0.0031
Echinococcus multilocularis lactate dehydrogenase a 0.0069 0.0309 0.0309
Schistosoma mansoni hypothetical protein 0.012 0.0618 0.1504
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0013 0.0031
Brugia malayi Bromodomain containing protein 0.012 0.0618 0.1946
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0215 0.0678
Echinococcus multilocularis transmembrane protease serine 3 0.0024 0.0036 0.0036
Echinococcus granulosus jumonji domain containing 1A 0.0039 0.0124 0.0302
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0036 0.0088
Loa Loa (eye worm) hypothetical protein 0.0068 0.0303 0.0956
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0002 0.0131
Echinococcus multilocularis integrin alpha ps 0.004 0.0134 0.0134
Echinococcus granulosus transmembrane protease serine 3 0.0024 0.0036 0.0088
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.054 0.3175 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0116 0.0595 0.1875
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0027 0.0052 0.0119
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0214 0.0522
Echinococcus granulosus JmjC domain containing protein 4 0.0039 0.0124 0.0302
Brugia malayi Trypsin family protein 0.0024 0.0036 0.0114
Echinococcus multilocularis integrin beta 2 0.0137 0.0721 0.0721
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0013 0.004
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0027 0.0052 0.0163
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0027 0.0052 0.0838
Echinococcus granulosus enteropeptidase 0.0024 0.0036 0.0088
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0088
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0127 0.0399
Onchocerca volvulus Alhambra homolog 0.012 0.0618 0.2287
Brugia malayi ecdysteroid receptor 0.002 0.0013 0.004
Echinococcus multilocularis Mastin 0.0024 0.0036 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0194 0.1067 0.2597
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0013 0.0031
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0036 0.0036
Echinococcus granulosus cytosolic malate dehydrogenase 0.0027 0.0052 0.0126
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0124 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.004
Brugia malayi hypothetical protein 0.0036 0.0105 0.033
Brugia malayi hypothetical protein 0.0462 0.2701 0.8508
Trypanosoma cruzi malate dehydrogenase, putative 0.0027 0.0052 0.418
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0101 0.0505 0.1192
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0124 0.039
Plasmodium vivax ornithine aminotransferase, putative 0.0101 0.0505 0.8182
Plasmodium vivax JmjC domain containing protein 0.0039 0.0124 0.2005
Schistosoma mansoni L-lactate dehydrogenase 0.0027 0.0052 0.0126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0392 0.2277 0.5543
Loa Loa (eye worm) TAR-binding protein 0.0193 0.1062 0.3344
Schistosoma mansoni smad 0.0024 0.0036 0.0087
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0036 0.0088
Echinococcus granulosus integrin beta 2 0.0137 0.0721 0.1755
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.2051 0.6461
Trichomonas vaginalis malate dehydrogenase, putative 0.0027 0.0052 0.0119
Brugia malayi hypothetical protein 0.0027 0.0052 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0099 0.023
Echinococcus granulosus smad 0.0024 0.0036 0.0087
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0163
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0127 1
Echinococcus granulosus lysine specific demethylase 6a 0.0039 0.0124 0.0302
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.054 0.3175 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0013 0.004
Echinococcus granulosus PHD finger protein rhinoceros 0.012 0.0618 0.1504
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0013 0.004

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 97 % Inhibition of human histamine H1 receptor ar 3 uM ChEMBL. 20580234
Ki (binding) = 22 nM Displacement of radio labeled 11 Tyr SST14 from human SST5 receptor expressed in CHO cells ChEMBL. 20580234

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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