Detailed information for compound 1098711

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 748.769 | Formula: C40H44O14
  • H donors: 3 H acceptors: 9 LogP: -0.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)/C(=C/1\C(=O)[C@H](O)[C@@]2(C3=C(C[C@@H]4[C@@]5([C@@H]13)OC(=O)C1=C5C[C@@H]3[C@]4(C)[C@@H]4C[C@@H]4[C@@]3(O)COC(=O)/C=C(\C)/COC(=O)[C@H](CC(=O)OC1)O)[C@@H]1[C@H]2C1)C)/C
  • InChi: 1S/C40H44O14/c1-15-6-27(42)53-14-39(49)23-9-22(23)37(3)25(39)10-21-19(13-51-28(43)11-24(41)36(48)52-12-15)35(47)54-40(21)26(37)8-18-17-7-20(17)38(4)30(18)31(40)29(32(44)33(38)45)16(2)34(46)50-5/h6,17,20,22-26,31,33,41,45,49H,7-14H2,1-5H3/b15-6+,29-16-/t17-,20-,22-,23+,24+,25-,26+,31+,33+,37+,38+,39+,40+/m1/s1
  • InChiKey: PHCXHKSHMYZRPK-WPCIVLODSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ets-related 0.0256 0.1233 0.1419
Loa Loa (eye worm) hypothetical protein 0.011 0.0488 0.2356
Brugia malayi Ets-domain containing protein 0.0084 0.036 0.1735
Schistosoma mansoni Smad4 0.0016 0.0013 0.0015
Schistosoma mansoni lamin 0.0026 0.0064 0.0073
Plasmodium falciparum kinesin-5 0.0257 0.1239 1
Echinococcus granulosus lamin 0.0026 0.0064 0.0064
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0041 0.0138 0.0158
Echinococcus multilocularis kinesin family 1 0.1978 1 1
Schistosoma mansoni hypothetical protein 0.0018 0.0024 0.0028
Loa Loa (eye worm) Smad1 0.0016 0.0013 0.0064
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0547
Brugia malayi MH2 domain containing protein 0.0016 0.0013 0.0064
Loa Loa (eye worm) GRP1 binding protein 0.0041 0.0138 0.0664
Echinococcus granulosus SPRY domain containing protein 0.0054 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0054 0.0207 0.0998
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0067 0.524
Echinococcus granulosus GA binding protein alpha chain 0.0084 0.036 0.036
Trypanosoma cruzi hypothetical protein 0.0032 0.0094 0.7964
Echinococcus multilocularis lamin dm0 0.0026 0.0064 0.0064
Echinococcus granulosus SPRY domain containing protein 0.0054 0.0207 0.0207
Echinococcus multilocularis Ezrin radixin moesin ERM 0.0054 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0039 0.0131 0.0631
Echinococcus multilocularis GPCR, family 2 0.008 0.034 0.034
Brugia malayi PHD-finger family protein 0.0026 0.0061 0.0293
Schistosoma mansoni hypothetical protein 0.008 0.034 0.0391
Onchocerca volvulus 0.0026 0.0064 0.027
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0054 0.0207 0.0207
Brugia malayi MH1 domain containing protein 0.0016 0.0013 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0327 0.0376
Onchocerca volvulus 0.0054 0.0207 0.0873
Onchocerca volvulus 0.0026 0.0064 0.027
Onchocerca volvulus Putative 4.1 G protein 0.0054 0.0207 0.0873
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.034 0.1638
Schistosoma mansoni hypothetical protein 0.0032 0.0094 0.0108
Echinococcus multilocularis radixin 0.0157 0.0732 0.0732
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0242 0.0242
Echinococcus multilocularis GA binding protein alpha chain 0.0084 0.036 0.036
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0036 0.0113 0.013
Schistosoma mansoni hypothetical protein 0.0018 0.0024 0.0028
Entamoeba histolytica hypothetical protein 0.0072 0.0295 0.2384
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0118 0.0118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0327 0.0327
Schistosoma mansoni gabp alpha 0.0084 0.036 0.0414
Echinococcus granulosus FERM domain containing protein 5 0.0054 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0042 0.0143 0.0691
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0002 0.001
Plasmodium vivax glutathione reductase, putative 0.0037 0.0117 0.0434
Onchocerca volvulus 0.0032 0.0094 0.0395
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.001
Echinococcus multilocularis smad 0.0016 0.0013 0.0013
Echinococcus granulosus intermediate filament protein 0.0026 0.0064 0.0064
Brugia malayi MH2 domain containing protein 0.0016 0.0013 0.0064
Echinococcus multilocularis SPRY domain containing protein 0.0054 0.0207 0.0207
Entamoeba histolytica hypothetical protein 0.0072 0.0295 0.2384
Brugia malayi MH1 domain containing protein 0.0016 0.0013 0.0064
Loa Loa (eye worm) neurofibromin 2 isoform 8 0.0032 0.0094 0.0451
Brugia malayi Fli-1 protein 0.0256 0.1233 0.5949
Echinococcus granulosus flap endonuclease 1 0.0027 0.0067 0.0067
Onchocerca volvulus 0.0104 0.046 0.194
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0117 1
Brugia malayi glutathione reductase 0.0037 0.0117 0.0567
Echinococcus granulosus protein tyrosine phosphatase non receptor type 0.0036 0.0113 0.0113
Echinococcus granulosus talin 2 0.0032 0.0094 0.0094
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.011 0.0488 0.2356
Echinococcus multilocularis FERM domain containing protein 5 0.0054 0.0207 0.0207
Schistosoma mansoni zinc finger protein 0.0016 0.0011 0.0012
Toxoplasma gondii kinesin motor domain-containing protein 0.0257 0.1239 1
Brugia malayi Kinesin motor domain containing protein 0.0257 0.1239 0.5976
Loa Loa (eye worm) moesin 0.0285 0.1383 0.6673
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0064 0.0308
Echinococcus multilocularis 0.0054 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0032 0.0094 0.0108
Echinococcus multilocularis FERM, C terminal PH domain 0.0022 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0041 0.0138 0.0158
Brugia malayi Moesin/ezrin/radixin homolog 1 0.0285 0.1383 0.6673
Echinococcus multilocularis SPRY domain containing protein 0.0054 0.0207 0.0207
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.002 0.0023
Brugia malayi protein-tyrosine-phosphatase 0.0036 0.0113 0.0547
Echinococcus multilocularis Pleckstrin y 0.0054 0.0207 0.0207
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0117 0.0567
Echinococcus granulosus SPRY domain containing protein 0.0054 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0054 0.0207 0.0998
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0238 0.0274
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0176 0.0826 0.095
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0012
Echinococcus granulosus Pleckstrin y 0.0054 0.0207 0.0207
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0814 0.3927
Brugia malayi Thioredoxin reductase 0.0037 0.0117 0.0567
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0054 0.0207 0.0207
Echinococcus multilocularis H17g protein, tegumental antigen 0.0285 0.1383 0.1383
Brugia malayi Ferm domain (protein4.1-ezrin-radixin-moesin) family protein 4-like 0.0036 0.0113 0.0547
Echinococcus granulosus FERM domain containing protein 5 0.0036 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0072 0.0298 0.1435
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0285 0.1383 0.1591
Brugia malayi hypothetical protein 0.0072 0.0295 0.1425
Loa Loa (eye worm) hypothetical protein 0.0254 0.1223 0.59
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0054 0.0207 0.0207
Brugia malayi MH2 domain containing protein 0.0238 0.1141 0.5503
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0023 0.011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0357 0.8342
Echinococcus granulosus H17g protein tegumental antigen 0.0285 0.1383 0.1383
Echinococcus multilocularis protein tyrosine phosphatase, non receptor type 0.0036 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0032 0.0094 0.0108
Echinococcus multilocularis FERM domain containing protein 5 0.0036 0.0113 0.0113
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0227 0.0227
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0013 0.0013
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0404 1
Schistosoma mansoni hypothetical protein 0.0032 0.0094 0.0108
Echinococcus multilocularis FERM domain containing protein 3 0.0036 0.0113 0.0113
Brugia malayi hypothetical protein 0.0036 0.0113 0.0547
Schistosoma mansoni hypothetical protein 0.0021 0.0038 0.0044
Leishmania major trypanothione reductase 0.0037 0.0117 1
Echinococcus granulosus Smad4 0.0016 0.0013 0.0013
Trypanosoma brucei trypanothione reductase 0.0037 0.0117 1
Echinococcus multilocularis zinc finger protein 0.002 0.0033 0.0033
Echinococcus granulosus GPCR family 2 0.008 0.034 0.034
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0238 0.1462
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0067 0.0537
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0054 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.008 0.034 0.0391
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0118 0.0118
Schistosoma mansoni zinc finger protein 0.002 0.0033 0.0038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0404 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0117 0.0434
Onchocerca volvulus 4.1 G protein, putative homolog 0.0032 0.0094 0.0395
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.1223 0.59
Plasmodium vivax SET domain protein, putative 0.006 0.0238 0.1462
Onchocerca volvulus 0.0054 0.0207 0.0873
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.046 0.0529
Brugia malayi GRP1 binding protein 0.0054 0.0207 0.0998
Schistosoma mansoni bromodomain containing protein 0.0065 0.0261 0.03
Schistosoma mansoni smad1 5 8 and 0.0016 0.0013 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0308
Echinococcus multilocularis talin 0.0032 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0032 0.0094 0.0108
Brugia malayi hypothetical protein 0.011 0.0488 0.2356
Brugia malayi FERM domain 0.0054 0.0207 0.0998
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0067 0.5666
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.034 0.034
Echinococcus multilocularis musashi 0.0026 0.0064 0.0064
Brugia malayi hypothetical protein 0.0054 0.0207 0.0998
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.034 0.034
Echinococcus multilocularis talin 2 0.0032 0.0094 0.0094
Loa Loa (eye worm) glutathione reductase 0.0037 0.0117 0.0567
Toxoplasma gondii thioredoxin reductase 0.0037 0.0117 0.0434
Schistosoma mansoni smad 0.0016 0.0013 0.0015
Echinococcus granulosus ezrin 0.0157 0.0732 0.0732
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0067 0.0281
Entamoeba histolytica kinesin, putative 0.0257 0.1239 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0153 0.0739
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0357 0.8342
Schistosoma mansoni Band 4.1-like protein 0.0054 0.0207 0.0238
Brugia malayi Flap endonuclease-1 0.0027 0.0067 0.0321
Brugia malayi neurofibromatosis homolog protein 1 0.0164 0.0765 0.3688
Loa Loa (eye worm) kinesin-like protein KLP2 0.0257 0.1239 0.5976
Schistosoma mansoni hypothetical protein 0.0174 0.0814 0.0937
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0084 0.036 0.1735
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0013 0.0013
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0357 0.8342
Echinococcus granulosus merlin:moesin:ezrin:radixin 0.0054 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0022 0.0044 0.0051
Schistosoma mansoni lamin 0.0026 0.0064 0.0073
Trichomonas vaginalis set domain proteins, putative 0.0479 0.2369 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0013 0.0064
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0357 0.8342
Brugia malayi Ets-domain containing protein 0.0084 0.036 0.1735
Mycobacterium tuberculosis Probable reductase 0.0084 0.0357 0.8342
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0054 0.0207 0.0207
Echinococcus granulosus zinc finger protein 0.002 0.0033 0.0033
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0064 0.0308
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.002 0.0023
Schistosoma mansoni hypothetical protein 0.0197 0.0935 0.1075
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0013 0.0064
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0036 0.0113 0.013
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0253 0.122 0.1404
Echinococcus multilocularis lamin 0.0026 0.0064 0.0064
Schistosoma mansoni Radixin 0.0036 0.0113 0.013
Loa Loa (eye worm) hypothetical protein 0.0072 0.03 0.1445
Brugia malayi intermediate filament protein 0.0026 0.0064 0.0308
Loa Loa (eye worm) hypothetical protein 0.0078 0.0327 0.1577
Echinococcus granulosus radixin 0.0157 0.0732 0.0732
Echinococcus granulosus tumor protein p63 0.071 0.3544 0.3544
Echinococcus granulosus geminin 0.0197 0.0935 0.0935
Echinococcus multilocularis ezrin 0.0157 0.0732 0.0732
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0837 0.4192 0.4192
Schistosoma mansoni hypothetical protein 0.0197 0.0935 0.1075
Loa Loa (eye worm) fli-1 protein 0.0256 0.1233 0.5949
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.1141 0.5503
Plasmodium falciparum glutathione reductase 0.0037 0.0117 0.0434
Schistosoma mansoni smad1 5 8 and 0.0016 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0094 0.0451
Trypanosoma cruzi ISWI complex protein 0.0016 0.0011 0.0896
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0357 0.8342
Echinococcus multilocularis tumor protein p63 0.071 0.3544 0.3544
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2073 1
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0018 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.1721 0.8692 1
Schistosoma mansoni kinesin eg-5 0.0257 0.1239 0.1425
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0022 0.0044 0.0051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0242 0.0242
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0038 0.0185
Brugia malayi Pre-SET motif family protein 0.0421 0.2073 1
Echinococcus multilocularis merlin:moesin:ezrin:radixin 0.0054 0.0207 0.0207
Brugia malayi hypothetical protein 0.0018 0.0024 0.0117
Entamoeba histolytica filopodin, putative 0.0032 0.0094 0.0755
Schistosoma mansoni talin 2 0.0032 0.0094 0.0108
Schistosoma mansoni intermediate filament proteins 0.0026 0.0064 0.0073
Schistosoma mansoni hypothetical protein 0.0022 0.0044 0.0051
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0067 0.0321
Echinococcus granulosus Ezrin radixin moesin ERM 0.0054 0.0207 0.0207
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0117 0.0434
Loa Loa (eye worm) hypothetical protein 0.0054 0.0207 0.0998
Brugia malayi Smad1 0.0016 0.0013 0.0064
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0013 0.0015
Echinococcus granulosus smad 0.0016 0.0013 0.0013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.034 0.034
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0018 0.0024 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0295 0.0295
Brugia malayi Bromodomain containing protein 0.0039 0.0131 0.063
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0048 0.0056
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.012 0.012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.1223 0.59
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.002 0.002
Onchocerca volvulus 0.0054 0.0207 0.0873
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0238 0.0274
Schistosoma mansoni talin 0.0032 0.0094 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.1223 0.59
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.034 0.034
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0067 0.524
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0404 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0054 0.0207 0.0238
Schistosoma mansoni hypothetical protein 0.0054 0.0207 0.0238
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0327 0.0376
Entamoeba histolytica hypothetical protein 0.0072 0.0295 0.2384
Echinococcus granulosus lamin dm0 0.0026 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0207 0.0998
Echinococcus granulosus talin 0.0032 0.0094 0.0094
Brugia malayi Bromodomain containing protein 0.0077 0.0322 0.1553
Echinococcus granulosus FERM C terminal PH domain 0.0022 0.0044 0.0044
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0295 0.034
Loa Loa (eye worm) hypothetical protein 0.008 0.034 0.1638
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0048 0.0048
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.002 0.002
Echinococcus granulosus FERM domain containing protein 3 0.0036 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0032 0.0094 0.0108
Brugia malayi Ferm domain 0.0054 0.0207 0.0998
Echinococcus granulosus FERM domain containing protein 3 0.0054 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.008 0.034 0.0391
Echinococcus multilocularis geminin 0.0197 0.0935 0.0935
Schistosoma mansoni hypothetical protein 0.0072 0.0295 0.034
Schistosoma mansoni hypothetical protein 0.0054 0.0207 0.0238
Echinococcus granulosus FERM central domain 0.0036 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0117
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0054 0.0207 0.0207
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.034 0.1638
Brugia malayi Ferm domain 0.0054 0.0207 0.0998
Brugia malayi Talin 1 0.0032 0.0094 0.0451
Echinococcus multilocularis FERM domain containing protein 3 0.0054 0.0207 0.0207
Giardia lamblia Kinesin-5 0.0257 0.1239 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0013 0.0015
Echinococcus multilocularis FERM central domain 0.0036 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0104 0.046 0.2217
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0064 0.0308
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0296
Trypanosoma cruzi ribonuclease inhibitor, putative 0.0032 0.0094 0.7964
Onchocerca volvulus 0.0479 0.2369 1
Plasmodium vivax kinesin-5 0.0257 0.1239 1
Trypanosoma cruzi ribonuclease inhibitor, putative 0.0032 0.0094 0.7964
Schistosoma mansoni flap endonuclease-1 0.0024 0.0054 0.0062
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0404 1
Schistosoma mansoni hypothetical protein 0.008 0.034 0.0391
Loa Loa (eye worm) hypothetical protein 0.0054 0.0207 0.0998
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0013 0.0013
Onchocerca volvulus 0.006 0.0238 0.1005
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0048 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.1141 0.5503
Echinococcus multilocularis Smad4 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0174 0.0814 0.3927
Trypanosoma cruzi ISWI complex protein 0.0016 0.0011 0.0896
Entamoeba histolytica hypothetical protein 0.0072 0.0295 0.2384
Echinococcus granulosus protein 4.1 0.0054 0.0207 0.0207
Brugia malayi Pre-SET motif family protein 0.006 0.0238 0.1148
Brugia malayi Latrophilin receptor protein 2 0.008 0.034 0.1638

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 0.022 uM Cytotoxicity against human C8166 cells by MTT assay ChEMBL. 21650224

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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