Detailed information for compound 1099854

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.477 | Formula: C21H32O3
  • H donors: 1 H acceptors: 2 LogP: 4.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@]1(C)CCC[C@@]2([C@@H]1CC[C@]13[C@H]2CC[C@H](C1)C(=C)[C@@H]3O)C
  • InChi: 1S/C21H32O3/c1-13-14-6-7-16-19(2)9-5-10-20(3,18(23)24-4)15(19)8-11-21(16,12-14)17(13)22/h14-17,22H,1,5-12H2,2-4H3/t14-,15+,16+,17+,19-,20-,21-/m1/s1
  • InChiKey: YTLCFXIFEIWKEL-WHCUZVCWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0029 0.0109
Schistosoma mansoni apoferritin-2 0.0008 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0176
Schistosoma mansoni thyroid hormone receptor 0.002 0.004 0.029
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0029 0.0109
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0 0.0008
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0193 0.0713
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0001 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0029 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.004 0.0054
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.1065 0.3928
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.004 0.029
Echinococcus granulosus importin subunit beta 1 0.0031 0.0078 0.0467
Echinococcus multilocularis survival motor neuron protein 1 0.0498 0.1662 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0187 0.1373
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0071
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0125 0.0462
Echinococcus granulosus FTZ F1 alpha 0.002 0.004 0.0238
Schistosoma mansoni ran 0.0023 0.005 0.0365
Trichomonas vaginalis ferritin, putative 0.0008 0 0.0043
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0489 0.1804
Brugia malayi glutathione reductase 0.0049 0.0138 0.0191
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0101 0.0609
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0007 0.0055
Brugia malayi CXXC zinc finger family protein 0.0029 0.0069 0.0095
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0105 0.0387
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0045
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0029 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0016 0.0026 0.0096
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0004 0.0022
Schistosoma mansoni inositol monophosphatase 0.0036 0.0094 0.0691
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0004 0.0022
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0012 0.0044
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.004 0.004
Entamoeba histolytica hypothetical protein 0.0036 0.0094 0.4858
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0101 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.004 0.0054
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0101 0.0609
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0004 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0024 0.0144
Brugia malayi hypothetical protein 0.0036 0.0094 0.0129
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0012 0.0044
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0177
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.005 0.0183
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.004 0.0238
Onchocerca volvulus 0.002 0.004 0.004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.004 0.0238
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.005 0.0183
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0038 0.0141
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0016 0.0026 0.1341
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0038 0.3771
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0395 0.7208
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0006 0.002
Toxoplasma gondii thioredoxin reductase 0.0049 0.0138 0.0511
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0004 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Giardia lamblia DNA damage repair protein 0.0012 0.0012 0.0044
Brugia malayi nuclear hormone receptor 0.002 0.004 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.004 0.0054
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0004 0.0005
Echinococcus granulosus Smad4 0.0009 0.0001 0.0006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0038 0.0141
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0024 0.0144
Brugia malayi hypothetical protein 0.0009 0.0004 0.0005
Schistosoma mansoni Smad4 0.0009 0.0001 0.0008
Echinococcus multilocularis geminin 0.0172 0.0555 0.3338
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0012 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0061 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Brugia malayi nuclear receptor NHR-88 0.0009 0.0004 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.004 0.029
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0038 0.0053
Echinococcus multilocularis ferritin 0.0008 0 0.0003
Onchocerca volvulus Bile acid receptor homolog 0.002 0.004 0.004
Echinococcus granulosus smad 0.0009 0.0001 0.0006
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0006 0.0348
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0101 0.0743
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0094 0.0347
Entamoeba histolytica hypothetical protein 0.0036 0.0094 0.4858
Schistosoma mansoni DNA helicase recq1 0.002 0.0038 0.028
Brugia malayi nuclear receptor NHR-67 0.0009 0.0004 0.0005
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.1103 0.664
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0014 0.0019
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0041
Onchocerca volvulus 0.0009 0.0004 0.0004
Echinococcus multilocularis bloom syndrome protein 0.002 0.0038 0.023
Leishmania major DNA damage repair protein, putative 0.0012 0.0012 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0045
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0004 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0179 0.1312
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0029 0.2907
Echinococcus granulosus expressed protein 0.0008 0 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.004 0.0054
Entamoeba histolytica Ran family GTPase 0.0023 0.005 0.2569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.004 0.0238
Schistosoma mansoni ferritin 0.0008 0 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.004 0.0054
Schistosoma mansoni ferritin 0.0008 0 0.0003
Brugia malayi DNA polymerase I family protein 0.0016 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0238
Plasmodium falciparum thioredoxin reductase 0.0017 0.0029 0.0109
Schistosoma mansoni ferritin light chain 0.0008 0 0.0003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0006 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0004 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.004 0.0054
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0101 0.5237
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0004 0.0022
Leishmania major trypanothione reductase 0.0049 0.0138 0.0511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.004 0.0238
Echinococcus granulosus twinkle protein mitochondrial 0.0012 0.0012 0.007
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Plasmodium falciparum glutathione reductase 0.0049 0.0138 0.0511
Brugia malayi steroid hormone receptor 0.002 0.004 0.0054
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.004 0.0238
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0187 0.1125
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0395 0.7208
Echinococcus multilocularis smad 0.0009 0.0001 0.0006
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0004 0.0027
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0004 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0094 0.9303
Entamoeba histolytica recQ family DNA helicase 0.001 0.0006 0.0287
Loa Loa (eye worm) RNA binding protein 0.0063 0.0187 0.1125
Brugia malayi MH2 domain containing protein 0.0127 0.0404 0.0556
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.0596 0.3588
Schistosoma mansoni ferritin light chain 0.0008 0 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.004 0.0238
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0157 0.0578
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0029 0.0109
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0012 0.0044
Toxoplasma gondii RNA-directed DNA polymerase 0.0807 0.2711 1
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0176
Onchocerca volvulus 0.0029 0.0069 0.0069
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0101 0.1849
Schistosoma mansoni hypothetical protein 0.0036 0.0094 0.069
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0238
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Brugia malayi nuclear receptor NHR-88 0.002 0.004 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0012 0.0044
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0011
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0058 0.5689
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.004 0.0054
Entamoeba histolytica recQ family helicase, putative 0.001 0.0004 0.022
Echinococcus granulosus geminin 0.0172 0.0555 0.3338
Schistosoma mansoni smad1 5 8 and 0.0009 0.0001 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.004 0.0238
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0101 0.0373
Brugia malayi tailless protein 0.0009 0.0004 0.0005
Brugia malayi Smad1 0.0009 0.0001 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0004 0.0031
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0138 0.0833
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0038 0.3771
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.005 0.0183
Plasmodium falciparum thioredoxin reductase 0.0049 0.0138 0.0511
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0038 0.3771
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0029 0.1827
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0238
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Brugia malayi polk-prov protein 0.0012 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0031 0.0078 0.0467
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0058 0.0212
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0138 0.0511
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0029 0.0109
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0101 0.0743
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.1065 0.3928
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.004 0.0238
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0045
Leishmania major DNA polymerase eta, putative 0.0037 0.0097 0.0359
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0038 0.023
Giardia lamblia Telomerase catalytic subunit 0.0807 0.2711 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0029 0.0109
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0238
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0038 0.0141
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0187 0.1373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.0596 0.4378
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0101 0.0139
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0024 0.0144
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Mycobacterium ulcerans hypothetical protein 0.0012 0.0012 0.0216
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0038 0.0141
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0016 0.0026 0.0096
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.005 0.0183
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0352 0.6433
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0012 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0109
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0001 0.0006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0058 0.5689
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.004 0.0238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0109
Brugia malayi hypothetical protein 0.0087 0.0268 0.0368
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.004 0.0054
Leishmania major importin beta-1 subunit, putative 0.0025 0.0058 0.0212
Schistosoma mansoni cpg binding protein 0.0029 0.0069 0.0508
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0097 0.0359
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0038 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Schistosoma mansoni inositol monophosphatase 0.0036 0.0094 0.0691
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0156
Plasmodium falciparum telomerase reverse transcriptase 0.0807 0.2711 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Brugia malayi Steroid receptor seven-up type 2 0.002 0.004 0.0054
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0038 0.023
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0039 0.0105 0.0387
Trypanosoma brucei telomerase reverse transcriptase 0.0807 0.2711 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0061 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0049 0.0137 0.0825
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.004 0.0238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0109
Loa Loa (eye worm) hypothetical protein 0.0087 0.0268 0.161
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Schistosoma mansoni DNA helicase recq5 0.002 0.0038 0.028
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0029 0.0538
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0078 0.0286
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0024 0.0144
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0138 0.0511
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0039 0.0105 0.1915
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0004 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.0596 0.3588
Echinococcus granulosus dnaJ subfamily B 0.041 0.1362 0.8195
Brugia malayi MH2 domain containing protein 0.0009 0.0001 0.0001
Toxoplasma gondii hypothetical protein 0.0052 0.0148 0.0546
Echinococcus multilocularis twinkle protein, mitochondrial 0.0012 0.0012 0.007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0187 0.1125
Leishmania major DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Schistosoma mansoni cpg binding protein 0.003 0.0075 0.0549
Echinococcus granulosus cpg binding protein 0.003 0.0075 0.045
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0 0.0008
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.004 0.0238
Schistosoma mansoni coup transcription factor 0.002 0.004 0.029
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0094 0.9303
Mycobacterium tuberculosis Conserved hypothetical protein 0.017 0.0547 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0268 0.161
Treponema pallidum DNA polymerase I (polA) 0.0055 0.0159 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0193 0.0266
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0404 0.243
Chlamydia trachomatis DNA polymerase I 0.0055 0.0159 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.0016
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0216
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0138 0.0833
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.004 0.0238
Plasmodium falciparum importin beta, putative 0.0031 0.0078 0.0286
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0019 0.0037 0.0136
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0004 0.0022
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.004 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.004 0.0054
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0193 0.0713
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0004 0.0022
Echinococcus granulosus bloom syndrome protein 0.002 0.0038 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.0596 0.3588
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0004 0.0022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.004 0.029
Echinococcus multilocularis cpg binding protein 0.003 0.0075 0.045
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.01 0.0601
Treponema pallidum bacterioferrin (TpF1) 0.0008 0 0.0027
Echinococcus multilocularis snurportin 1 0.0333 0.1103 0.664
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0004 0.0022
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0125 0.0462
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0016 0.0026 0.0096
Echinococcus multilocularis Smad4 0.0009 0.0001 0.0006
Leishmania major GTP-binding protein, putative 0.0023 0.005 0.0183
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0101 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.004 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0101 0.0373
Echinococcus multilocularis FTZ F1 alpha 0.002 0.004 0.0238
Schistosoma mansoni cpg binding protein 0.003 0.0075 0.0549
Brugia malayi Telomerase reverse transcriptase 0.2148 0.7261 1
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0004 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0238
Plasmodium vivax telomerase reverse transcriptase, putative 0.0807 0.2711 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.004 0.0054
Brugia malayi conserved hypotetical protein 0.0009 0.0004 0.0005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.005 0.0183
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0014 0.0019
Giardia lamblia DINP protein human, muc B family 0.0038 0.0101 0.0373
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0187 0.1373
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0085 0.051
Trichomonas vaginalis DNA polymerase I, putative 0.0016 0.0026 0.256
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0029 0.1827
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0101 0.1849
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0029 0.0109
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0038 0.023
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0029 0.0109
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0016 0.0026 0.0096
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0538
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.004 0.029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0101 0.1849
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0109
Plasmodium falciparum plastid replication-repair enzyme 0.0016 0.0026 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.0596 0.3588
Echinococcus granulosus ferritin 0.0008 0 0.0003
Mycobacterium tuberculosis Probable reductase 0.0112 0.0352 0.6433
Echinococcus granulosus survival motor neuron protein 1 0.0498 0.1662 1
Brugia malayi ecdysteroid receptor 0.002 0.004 0.0054
Plasmodium vivax glutathione reductase, putative 0.0049 0.0138 0.0511
Brugia malayi TAR-binding protein 0.0063 0.0187 0.0257
Loa Loa (eye worm) DR-78 0.0009 0.0004 0.0022
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0012 0.0044
Echinococcus multilocularis GPCR, family 2 0.0015 0.0024 0.0144
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0029 0.0109
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0097 0.0359
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0006 0.002
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0094 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.004 0.0238
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0137 0.0825
Schistosoma mansoni zinc finger protein 0.0009 0.0004 0.0027
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0001 0.0008
Loa Loa (eye worm) inositol-1 0.0036 0.0094 0.0567
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0038 0.023
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0045
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0038 0.023
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0094 0.172
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0094 0.0347
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0024 0.0144
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0193 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0024 0.0033
Loa Loa (eye worm) glutathione reductase 0.0049 0.0138 0.0833
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.004 0.0238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0109
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.004 0.029
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0105 0.0387
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0404 0.243
Schistosoma mansoni DNA polymerase I 0.0016 0.0026 0.019
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0055 0.0159 0.4033
Leishmania major telomerase reverse transcriptase, putative 0.0807 0.2711 1
Plasmodium falciparum glutathione reductase 0.0017 0.0029 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0004 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.004 0.0054
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.004 0.0054
Schistosoma mansoni smad1 5 8 and 0.0009 0.0001 0.0008
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.005 0.0183
Schistosoma mansoni smad 0.0009 0.0001 0.0008
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.004 0.0238
Onchocerca volvulus 0.0102 0.0316 0.0316
Plasmodium vivax plastid replication-repair enzyme, putative 0.0016 0.0026 0.0096
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0012 0.0044
Echinococcus granulosus dna polymerase eta 0.0063 0.0187 0.1124
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.0596 0.4378
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0193 0.1163
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0038 0.0141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0029 0.0109
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.005 0.0299
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0004 0.0022
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0029 0.1849
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0045
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0006 0.002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0137 0.0189
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0078 0.0286
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0352 0.8924
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0094 0.069
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0029 0.0109
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0094 0.0565
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0125 0.0462
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.0596 0.4378
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0029 0.0538
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0016 0.0026 0.0096
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0058 0.5689
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0094 0.0347
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0055
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0137 0.0189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.0596 0.3588
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0101 0.1849
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0012 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0001 0.0006
Schistosoma mansoni hypothetical protein 0.0172 0.0555 0.4073
Brugia malayi nuclear hormone receptor 0.0009 0.0004 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.004 0.0238
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0238
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0012 0.0044
Schistosoma mansoni ran 0.0023 0.005 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0187 0.1373
Leishmania major DNA polymerase eta, putative 0.0063 0.0187 0.0689
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0038 0.0141
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0001 0.0006
Schistosoma mansoni nuclear hormone receptor 0.002 0.004 0.029
Brugia malayi RNA, U transporter 1 0.0089 0.0273 0.0376
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0045
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0094 0.4872
Schistosoma mansoni thyroid hormone receptor 0.002 0.004 0.029
Mycobacterium ulcerans hypothetical protein 0.017 0.0547 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0094 0.0565
Trypanosoma brucei trypanothione reductase 0.0049 0.0138 0.0511
Schistosoma mansoni hypothetical protein 0.0333 0.1103 0.8102
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0038 0.0141
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0012 0.0087
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.005 0.0183
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0105 0.0387
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.004 0.029
Schistosoma mansoni ferritin 0.0008 0 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0001 0.0006
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0807 0.2711 1
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.1065 0.3928
Leishmania major DNA polymerase kappa, putative 0.0012 0.0012 0.0044
Schistosoma mansoni hypothetical protein 0.0033 0.0085 0.0622
Echinococcus multilocularis dnaJ subfamily B 0.041 0.1362 0.8195
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0138 0.0833
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0078 0.0467
Schistosoma mansoni DNA polymerase eta 0.0063 0.0187 0.1371
Loa Loa (eye worm) twinkle helicase 0.0012 0.0012 0.007
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0395 0.7208
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0316 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0187 0.0689
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.004 0.004
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0081 0.1486
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0004 0.0022
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0055 0.0159 1
Schistosoma mansoni hypothetical protein 0.0172 0.0555 0.4073
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0238
Brugia malayi MH1 domain containing protein 0.0009 0.0001 0.0001
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0807 0.2711 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0012 0.0044
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0016 0.0026 0.0096
Brugia malayi hypothetical protein 0.0009 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.041 0.1362 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0125 0.0462
Schistosoma mansoni eyes absent homolog 0.0087 0.0268 0.1964
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0029 0.0538
Plasmodium vivax importin-beta 2, putative 0.0031 0.0078 0.0286
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0004 0.0005
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0101 0.0373
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0029 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0044
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0004 0.0022
Mycobacterium ulcerans 5'-3' exonuclease 0.0039 0.0105 0.1915
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0193 0.1163
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0069 0.0417
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0193 0.0713
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.004 0.029
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.004 0.0238
Entamoeba histolytica hypothetical protein 0.0025 0.0058 0.2979
Brugia malayi hypothetical protein 0.0498 0.1662 0.2289
Echinococcus granulosus tar DNA binding protein 0.0063 0.0187 0.1125
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0078 0.0286
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.1124
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0004 0.0022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0395 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0352 0.6433
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0 0.0008
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0038 0.0053
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0012 0.0044
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0012 0.0012 0.0012
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0055 0.0159 0.2907
Schistosoma mansoni importin beta-1 0.0031 0.0078 0.057
Schistosoma mansoni apoferritin-2 0.0008 0 0.0003
Brugia malayi nuclear receptor RXR 0.0009 0.0004 0.0005
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0038 0.0141
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0187 0.0689
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0187 0.1373
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0193 0.1163
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0004 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0001 0.0006
Echinococcus granulosus transcription factor Dp 1 0.0038 0.01 0.0601
Echinococcus granulosus dna polymerase kappa 0.0038 0.0101 0.0609
Loa Loa (eye worm) steroid hormone receptor 0.002 0.004 0.0238
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0085 0.0117
Echinococcus granulosus snurportin 1 0.0333 0.1103 0.664
Entamoeba histolytica hypothetical protein 0.0036 0.0094 0.4858
Echinococcus granulosus GPCR family 2 0.0015 0.0024 0.0144
Trypanosoma brucei unspecified product 0.0026 0.0061 0.0225
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0001 0.0002
Schistosoma mansoni survival motor neuron protein 0.0102 0.0316 0.2323
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0498 0.1662 1
Brugia malayi MH1 domain containing protein 0.0009 0.0001 0.0001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.005 0.0299
Schistosoma mansoni smad1 5 8 and 0.0009 0.0001 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0029 0.0109
Entamoeba histolytica recQ family helicase, putative 0.002 0.0038 0.1975
Mycobacterium ulcerans DNA polymerase I 0.0055 0.0159 0.2907
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0105 0.0387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.004 0.0238
Schistosoma mansoni hypothetical protein 0.0102 0.0316 0.2323
Trypanosoma brucei unspecified product 0.0038 0.0101 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Brugia malayi MH2 domain containing protein 0.0009 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0004 0.0027
Trypanosoma brucei unspecified product 0.0026 0.0061 0.0225
Trichomonas vaginalis ran, putative 0.0023 0.005 0.4904
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.1065 0.3928
Toxoplasma gondii helicase, putative 0.0016 0.0026 0.0096
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0094 0.5906
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0138 0.2529
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0489 0.1804
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0094 0.9303
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0004 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0238
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0004 0.0027
Echinococcus multilocularis expressed protein 0.0008 0 0.0003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0352 0.6433
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0011
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0193 0.0713
Brugia malayi nuclear receptor RXR 0.0011 0.0007 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0109
Onchocerca volvulus 0.0009 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.004 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0101 0.0373
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Brugia malayi ecdysone receptor 0.0009 0.0004 0.0005
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0489 0.1804
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0352 0.6433
Brugia malayi RNA binding protein 0.0063 0.0187 0.0257
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0094 0.0567
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.004 0.0238
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0081 0.2061
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0193 0.1419
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.005 0.0068
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0029 0.0109
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0159 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0061 0.0225
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0187 0.0257
Schistosoma mansoni ferritin 0.0008 0 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.004 0.0238
Brugia malayi Thioredoxin reductase 0.0049 0.0138 0.0191
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0176
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0029 0.2907
Brugia malayi Importin beta-1 subunit 0.0031 0.0078 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.004 0.0238
Entamoeba histolytica hypothetical protein 0.0036 0.0094 0.4858
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.0596 0.0821
Schistosoma mansoni nuclear receptor 0.0009 0.0004 0.0027
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.005 0.0299
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.004 0.0238
Brugia malayi Inositol-1 0.0036 0.0094 0.013
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0187 0.1125
Schistosoma mansoni nuclear receptor 0.0009 0.0004 0.0027
Loa Loa (eye worm) Smad1 0.0009 0.0001 0.0006
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0012 0.0044
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0352 0.6433
Treponema pallidum NADH oxidase 0.0017 0.0029 0.1849
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0101 0.0609
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0094 0.0347
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0007 0.0045
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0176
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0101 0.0373
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0039 0.0105 0.0387
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0 0.0008
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0024 0.0033
Loa Loa (eye worm) RecQ helicase 0.002 0.0038 0.023
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.023
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0101 0.0609
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0011
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0 0.0011
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0187 0.0257
Echinococcus multilocularis dna polymerase eta 0.0063 0.0187 0.1124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0109
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0094 0.0347

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 97 % Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 1 to 25 uM pretreated for 15 mins before LPS challenge measured after 24 hrs by MTT assay ChEMBL. 21334121
IC50 (functional) = 5 uM Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release pretreated for 15 mins before LPS challenge measured after 24 hrs by Griess method ChEMBL. 21334121
IC50 (functional) > 100 uM Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay ChEMBL. 20116261

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 21334121

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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