Detailed information for compound 1117706

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 505.04 | Formula: C28H35ClF2N2O2
  • H donors: 1 H acceptors: 2 LogP: 5.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)[C@]1(O)[C@@H](C)CN(C[C@H]1C)C(=O)[C@@H]1CN(C[C@H]1c1ccc(cc1F)F)C(C)(C)C
  • InChi: 1S/C28H35ClF2N2O2/c1-17-13-32(14-18(2)28(17,35)19-6-8-20(29)9-7-19)26(34)24-16-33(27(3,4)5)15-23(24)22-11-10-21(30)12-25(22)31/h6-12,17-18,23-24,35H,13-16H2,1-5H3/t17-,18+,23-,24+,28-/m0/s1
  • InChiKey: GXEILWZMBSGTIK-XYLBCIRHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Starlite/ChEMBL References
Homo sapiens melanocortin 5 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 3 receptor Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melanocortin 5 receptor 325 aa 311 aa 20.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0006 0.0006
Brugia malayi neuropeptide F receptor 0.0011 0.0006 0.0022
Schistosoma mansoni alpha-glucosidase 0.0139 0.061 0.061
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0357 0.0981
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.051 0.1254
Echinococcus multilocularis sex peptide receptor 0.0011 0.0006 0.0006
Brugia malayi Thioredoxin reductase 0.0038 0.0129 0.0504
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable lipase LipD 0.0118 0.051 0.1417
Schistosoma mansoni myosin xvIII 0.0011 0.0006 0.0006
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0033 0.0109 0.0109
Onchocerca volvulus 0.0011 0.0006 0.0052
Brugia malayi G-protein coupled receptor 0.0011 0.0006 0.0022
Brugia malayi Pre-SET motif family protein 0.0032 0.0104 0.0407
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Schistosoma mansoni biogenic amine receptor 0.0011 0.0006 0.0006
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0131 0.0323
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0131 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0121 0.0294
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.032 0.032
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0065 0.0259 0.0259
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0013 0.0973
Echinococcus granulosus sex peptide receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0397 0.0397
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.2283
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Loa Loa (eye worm) hypothetical protein 0.0038 0.0131 0.0511
Brugia malayi Serotonin receptor 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable reductase 0.0086 0.0357 0.0981
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.007 0.1264
Onchocerca volvulus 0.0011 0.0006 0.0052
Onchocerca volvulus Huntingtin homolog 0.0121 0.0527 0.4772
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0403 0.111
Brugia malayi sulfakinin receptor protein 0.0011 0.0006 0.0022
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0006 0.0022
Brugia malayi hypothetical protein 0.0121 0.0527 0.2053
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Echinococcus granulosus nervana 2 0.0065 0.0259 0.0259
Echinococcus multilocularis beta tubulin 0.0027 0.0081 0.0081
Onchocerca volvulus 0.0032 0.0104 0.0946
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0118 0.051 0.199
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0121 0.0294
Echinococcus granulosus somatostatin receptor 0.0011 0.0006 0.0006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.0746 0.9112
Loa Loa (eye worm) hypothetical protein 0.0121 0.0527 0.2053
Brugia malayi glutaminase DH11.1 0.055 0.2564 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Treponema pallidum fructose-bisphosphate aldolase 0.0865 0.4057 1
Plasmodium falciparum importin beta, putative 0.0029 0.009 0.6979
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0129 0.2364
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0716 0.2793
Giardia lamblia Beta tubulin 0.0027 0.0081 0.0186
Echinococcus granulosus g protein coupled receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis beta tubulin 0.0027 0.0081 0.0081
Onchocerca volvulus 0.0011 0.0006 0.0052
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0006 0.0022
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0011 0.011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0368 0.1435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0005 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0397 0.0397
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0013 0.0011 0.0011
Echinococcus granulosus Na:K ATPase alpha subunit 0.0033 0.0109 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0818 0.3093
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.0502 0.0502
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.0818 0.0818
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0006 0.0006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0006 0.0006
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0223
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0013 0.0142
Onchocerca volvulus 0.0088 0.0368 0.3336
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0013 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Echinococcus granulosus hypothetical protein 0.0011 0.0006 0.0006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.0502 0.1879
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0006 0.0006
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0006 0.0006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0088
Schistosoma mansoni elf1 0.0011 0.0005 0.0005
Brugia malayi ORL1-like opioid receptor 0.0011 0.0006 0.0022
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0013 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0131 0.0319
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0271
Schistosoma mansoni alpha-glucosidase 0.0139 0.061 0.061
Schistosoma mansoni hypothetical protein 0.125 0.5888 0.5888
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0006 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.004 0.0154
Leishmania major P-type ATPase, putative 0.0013 0.0011 0.0068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0131 0.0309
Brugia malayi beta-tubulin, identical 0.0027 0.0081 0.0316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0006 0.0022
Leishmania major importin beta-1 subunit, putative 0.0024 0.0064 0.0717
Echinococcus multilocularis tubulin subunit beta 0.0027 0.0081 0.0081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Brugia malayi Dopamine receptor 0.0011 0.0006 0.0022
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0006 0.0006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0013
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0112 0.0283
Leishmania major calcium-transporting ATPase, putative 0.0013 0.0011 0.0068
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0064 0.0153
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0029 0.0088 0.0342
Trichomonas vaginalis tubulin gamma chain, putative 0.0027 0.0081 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0357 0.0981
Mycobacterium ulcerans glutaminase 0.055 0.2564 0.9785
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0014 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.051 1
Brugia malayi Augmenter of liver regeneration 0.0037 0.0126 0.049
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0562 0.262 0.7427
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.0297
Onchocerca volvulus 0.0118 0.051 0.4626
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0818 0.3093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0081 0.0195
Onchocerca volvulus 0.0011 0.0006 0.0052
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.007 0.1167
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.051 0.051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0104 0.0104
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Toxoplasma gondii aldehyde dehydrogenase 0.0183 0.0818 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trypanosoma brucei beta tubulin 0.0027 0.0081 0.1489
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0006 0.0006
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0006 0.0006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0011 0.0023
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0005 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.1264
Echinococcus granulosus snurportin 1 0.0313 0.1437 0.1437
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.004 0.0669
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0006 0.0006
Echinococcus granulosus dnaJ subfamily B 0.125 0.5888 0.5888
Plasmodium falciparum glutathione reductase 0.0038 0.0129 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.006 0.006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium ulcerans esterase/lipase LipP 0.0118 0.051 0.1913
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0198 0.0198
Echinococcus granulosus cpg binding protein 0.0093 0.0392 0.0392
Loa Loa (eye worm) tubulin beta-2A chain 0.0027 0.0081 0.0316
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.051 0.1254
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.0502 0.1879
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis nervana 2 0.0065 0.0259 0.0259
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.5367
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.004 0.3036
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0006 0.0006
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni opsin-like receptor 0.0011 0.0006 0.0006
Brugia malayi Pre-SET motif family protein 0.0213 0.0965 0.3762
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0422 0.1957 0.7386
Trypanosoma brucei calcium-translocating P-type ATPase 0.0013 0.0011 0.011
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0131 1
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0006 0.0006
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0013 0.0142
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0006 0.0052
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0403 0.111
Echinococcus multilocularis somatostatin receptor 0.0011 0.0006 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0013 0.0142
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0006 0.0006
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0126 0.1476
Onchocerca volvulus 0.0011 0.0006 0.0052
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0126 0.9722
Loa Loa (eye worm) glutaminase 2 0.055 0.2564 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Schistosoma mansoni neuropeptide receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0013 0.0973
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0006 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0104 0.0407
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0081 0.0195
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.009 0.1676
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.051 0.1254
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0013 0.0018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0014 0.0172
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0865 0.4057 1
Brugia malayi G-protein coupled receptor 0.0011 0.0006 0.0022
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1103 0.2716
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.2486
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.3864 0.3864
Schistosoma mansoni adenoreceptor 0.0011 0.0006 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.004 0.0093
Toxoplasma gondii thioredoxin reductase 0.0038 0.0129 0.152
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.0297
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0014 0.0172
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0006 0.0006
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0039 0.0135 0.0526
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.032 0.032
Brugia malayi Serotonin receptor 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0006 0.0022
Plasmodium falciparum tubulin beta chain 0.0027 0.0081 0.6248
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.004 0.0565
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0006 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Schistosoma mansoni microtubule-associated protein tau 0.2117 1 1
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0081 0.0316
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0006 0.0006
Brugia malayi Fli-1 protein 0.0236 0.107 0.4171
Plasmodium vivax glutathione reductase, putative 0.0038 0.0129 0.2364
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0126 0.1476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0088
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0792 0.1948
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus granulosus neuropeptide receptor 0.0011 0.0006 0.0006
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0081 0.0195
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.004 0.0096
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0163 0.0163
Onchocerca volvulus 0.0011 0.0006 0.0052
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.004 0.004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0104 0.0104
Plasmodium falciparum calcium-transporting ATPase 0.0013 0.0011 0.085
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.1167 0.4551
Echinococcus granulosus tumor protein p63 0.0355 0.1637 0.1637
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.051 0.1254
Mycobacterium tuberculosis Conserved protein 0.0118 0.051 0.1417
Brugia malayi G protein-coupled receptor 0.0011 0.0006 0.0022
Brugia malayi beta-lactamase 0.0118 0.051 0.199
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0118 0.051 0.1913
Echinococcus granulosus g protein coupled receptor 0.0011 0.0006 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.009 0.1676
Brugia malayi Dopamine receptor protein 2 0.0011 0.0006 0.0022
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0081 0.0316
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0005 0.0005
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Schistosoma mansoni ATPase 0.0011 0.0006 0.0006
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0126 0.2292
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0126 0.0126
Echinococcus granulosus tubulin beta 1 chain 0.0027 0.0081 0.0081
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0006 0.001
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0005 0.0018
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.0011 0.0044
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0004 0.0004
Schistosoma mansoni transmemberane protein 0.0065 0.0259 0.0259
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0013 0.0142
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0126 0.2377
Echinococcus granulosus calcium transporting atpase 0.0013 0.0011 0.0011
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0131 0.1542
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0013 0.0011 0.0011
Echinococcus multilocularis calcium transporting atpase 0.0013 0.0011 0.0011
Schistosoma mansoni opsin-like receptor 0.0011 0.0006 0.0006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.0011 0.0068
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.0013
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0013 0.0032
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0013 0.0088
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0006 0.0006
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0013 0.0011 0.0011
Brugia malayi Na,K-ATPase alpha subunit 0.0033 0.0109 0.0427
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis glutaminase, putative 0.055 0.2564 0.6319
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0005 0.0005
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0131 0.0319
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0149 0.0362
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0013 0.0013
Schistosoma mansoni inositol monophosphatase 0.0038 0.0131 0.0131
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0126 0.2377
Schistosoma mansoni ets 0.0011 0.0005 0.0005
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0013 0.0011 0.0027
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0163 0.0635
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0006 0.0006
Mycobacterium ulcerans lipase LipD 0.0118 0.051 0.1913
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0011 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0427
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) tubulin beta chain 0.0027 0.0081 0.0316
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0131 0.1544
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) tubulin beta-4 chain 0.0027 0.0081 0.0316
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0108 0.0465 0.1812
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.004 0.0066
Schistosoma mansoni glutaminase 0.055 0.2564 0.2564
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0006 0.0022
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0037 0.0126 0.1476
Mycobacterium tuberculosis Conserved protein 0.0118 0.051 0.1417
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0131 0.0319
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0006 0.0006
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0013 0.0011 0.0068
Echinococcus granulosus orexin receptor type 2 0.0011 0.0006 0.0006
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.0081 0.0195
Onchocerca volvulus 0.0243 0.1103 1
Echinococcus granulosus nervana 2 0.0065 0.0259 0.0259
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0006 0.0006
Echinococcus granulosus tubulin subunit beta 0.0027 0.0081 0.0081
Brugia malayi GnHR receptor homolog 0.0011 0.0006 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0716 0.2793
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.004 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0013 0.0013
Echinococcus multilocularis microtubule associated protein 2 0.2117 1 1
Brugia malayi RE15519p 0.0011 0.0006 0.0022
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Echinococcus granulosus importin subunit beta 1 0.0029 0.009 0.009
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0508 0.1982
Trypanosoma cruzi beta tubulin, putative 0.0027 0.0081 0.1489
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0118 0.051 0.1417
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0013 0.0011 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Loa Loa (eye worm) hypothetical protein 0.0066 0.0266 0.1038
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0006 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0182 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0131 0.2483
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0006 0.0006
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0011 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0118 0.051 0.051
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0357 0.0981
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0716 0.0716
Echinococcus granulosus serotonin receptor 0.0011 0.0006 0.0006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0865 0.4057 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Onchocerca volvulus Huntingtin homolog 0.0121 0.0527 0.4772
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0118 0.051 0.199
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis helicase, putative 0.002 0.0046 0.0108
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0131 0.0131
Brugia malayi Dopamine receptor protein 1 0.0011 0.0006 0.0022
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0052 0.0198 0.0772
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0183 0.0818 0.2294
Schistosoma mansoni neuropeptide receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0121 0.0294
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0397 0.1549
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Brugia malayi Ets-domain containing protein 0.0078 0.032 0.1246
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0013 0.0088
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.051 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0006 0.0006
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0131 0.0131
Schistosoma mansoni cpg binding protein 0.0088 0.0368 0.0368
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.004 0.2249
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0132 0.0132
Plasmodium vivax importin-beta 2, putative 0.0029 0.009 0.1583
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.006 0.006
Echinococcus multilocularis protein C ets 2 0.0011 0.0005 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.007 0.0785
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Schistosoma mansoni cpg binding protein 0.0093 0.0392 0.0392
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0104 0.1213
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0129 0.0504
Echinococcus granulosus nervana 2 0.0065 0.0259 0.0259
Brugia malayi hypothetical protein 0.0025 0.007 0.0271
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0006 0.0022
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Brugia malayi Inositol-1 0.0038 0.0131 0.0512
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0142
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0005 0.0018
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) tubulin beta-1 chain 0.0027 0.0081 0.0316
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0018
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.0011 0.0068
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0006 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0965 0.3762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0104 0.0104
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0014 0.0031
Plasmodium falciparum thioredoxin reductase 0.0038 0.0129 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0006 0.0022
Loa Loa (eye worm) glutathione reductase 0.0038 0.0129 0.0504
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0121 0.0472
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0121 0.0294
Toxoplasma gondii exonuclease III APE 0.0019 0.004 0.0415
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Loa Loa (eye worm) hypothetical protein 0.0121 0.0527 0.2053
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0006 0.0006
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0013 0.0088
Echinococcus multilocularis snurportin 1 0.0313 0.1437 0.1437
Mycobacterium ulcerans hypothetical protein 0.0118 0.051 0.1913
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0011 0.0006 0.001
Plasmodium vivax hypothetical protein, conserved 0.0118 0.051 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.1437 0.5603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0187 0.0841 0.0841
Mycobacterium ulcerans beta-lactamase 0.0118 0.051 0.1913
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0006 0.0006
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.1544
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.004 0.0108
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0006 0.0006
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0716 0.0716
Onchocerca volvulus 0.0011 0.0006 0.0052
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0422 0.1957 0.7457
Schistosoma mansoni neuropeptide receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0006 0.0022
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.1418
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0397 0.1549
Entamoeba histolytica hypothetical protein 0.0024 0.0064 0.0157
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0013 0.0088
Brugia malayi CXXC zinc finger family protein 0.0088 0.0368 0.1435
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis ets variant gene 4 0.0011 0.0005 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0006 0.0022
Brugia malayi Importin beta-1 subunit 0.0029 0.009 0.0352
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0289
Toxoplasma gondii ABC1 family protein 0.0118 0.051 0.621
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0006 0.001
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0006 0.0006
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0006 0.0006
Echinococcus multilocularis tubulin beta 1 chain 0.0027 0.0081 0.0081
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis nervana 2 0.0065 0.0259 0.0259
Brugia malayi beta-lactamase family protein 0.0118 0.051 0.199
Mycobacterium tuberculosis Probable esterase LipL 0.0118 0.051 0.1417
Trypanosoma brucei beta tubulin 0.0027 0.0081 0.1489
Onchocerca volvulus 0.0011 0.0006 0.0052
Schistosoma mansoni opsin-like receptor 0.0011 0.0006 0.0006
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0006 0.0006
Giardia lamblia Beta tubulin 0.0027 0.0081 0.0186
Onchocerca volvulus 0.0011 0.0006 0.0052
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0006 0.0006
Toxoplasma gondii beta-tubulin, putative 0.0027 0.0081 0.0925
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0033 0.0109 0.0427
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Echinococcus multilocularis serotonin receptor 0.0011 0.0006 0.0006
Brugia malayi Melatonin receptor type 1A 0.0011 0.0006 0.0022
Toxoplasma gondii beta-1 tubulin, putative 0.0027 0.0081 0.0925
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0006 0.0006
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0121 0.1418
Toxoplasma gondii P-type ATPase4, putative 0.0013 0.0011 0.0068
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0131 0.0131
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Onchocerca volvulus 0.0065 0.0259 0.2348
Plasmodium vivax SET domain protein, putative 0.0032 0.0104 0.1864
Leishmania major hypothetical protein, conserved 0.0118 0.051 0.621
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0129 0.2448
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Schistosoma mansoni importin beta-1 0.0029 0.009 0.009
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0013 0.0011 0.0011
Schistosoma mansoni gabp alpha 0.0078 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0352
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0142
Echinococcus multilocularis nervana 2 0.0065 0.0259 0.0259
Schistosoma mansoni cpg binding protein 0.0093 0.0392 0.0392
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis cpg binding protein 0.0093 0.0392 0.0392
Brugia malayi larval opioid receptor 0.0011 0.0006 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.004 0.0669
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0422 0.1957 0.5537
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0027 0.0081 0.0081
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0006 0.0006
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0006 0.0006
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.2283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0023
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0085 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0033 0.0109 0.0256
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0006 0.0006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0131 0.2483
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.009 0.009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0397 0.0397
Brugia malayi transcription factor E74 isoform 0.0011 0.0005 0.0018
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.032 0.1246
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0116 0.0502 0.0502
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0005 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0065 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0006 0.0006
Onchocerca volvulus 0.0065 0.0259 0.2348
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0006
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0005 0.0005
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0014 0.0172
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0752 0.3524 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0006 0.0052
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0131 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0126 0.2377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0397 0.0397
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Plasmodium falciparum thioredoxin reductase 0.0013 0.0013 0.0973
Leishmania major hypothetical protein, conserved 0.0025 0.007 0.0785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0121 0.0472
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0131 0.0131
Loa Loa (eye worm) beta-tubulin 0.0027 0.0081 0.0316
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0004
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.0011 0.011
Giardia lamblia Fructose-bisphosphate aldolase 0.0865 0.4057 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni histamine h1 receptor 0.0011 0.0006 0.0006
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0029 0.0088 0.0342
Echinococcus multilocularis beta LACTamase domain containing family member 0.0118 0.051 0.051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0085 0.0085
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus g protein coupled receptor 0.0011 0.0006 0.0006
Echinococcus granulosus beta tubulin 0.0027 0.0081 0.0081
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0013 0.0011 0.0011
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0064 0.1155
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0403 0.111
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni ATPase 0.0011 0.0006 0.0006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.2486
Onchocerca volvulus 0.0011 0.0006 0.0052
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0131 0.0319
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0163 0.0635
Trichomonas vaginalis tubulin, putative 0.0027 0.0081 0.0195
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0749 0.6788
Onchocerca volvulus 0.0011 0.0006 0.0052
Brugia malayi Tubulin beta-1 chain 0.0027 0.0081 0.0316
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0005 0.0005
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0818 0.3093
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0397 0.0397
Brugia malayi glutathione reductase 0.0038 0.0129 0.0504
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.0502 0.0502
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0046 0.0108
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0033 0.0109 0.0109
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.006 0.006
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0013 0.0011 0.0011
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0116 0.0502 0.1956
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0006 0.0022
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) glutaminase 0.055 0.2564 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0131 0.0319
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.2486
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0006 0.0006
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0006 0.0006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0397 0.0397
Trypanosoma brucei trypanothione reductase 0.0038 0.0129 0.2448
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0716 0.0716
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0183 0.0818 0.0818
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0006 0.0022
Onchocerca volvulus 0.0093 0.0394 0.3568
Schistosoma mansoni biogenic amine receptor 0.0011 0.0006 0.0006
Onchocerca volvulus 0.0011 0.0006 0.0052
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0013 0.0011 0.085
Onchocerca volvulus 0.0011 0.0006 0.0052
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0014 0.0107
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) beta-lactamase 0.0118 0.051 0.199
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0011 0.011
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.1264
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0116 0.0502 0.1392
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0006 0.0006
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0005 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0016 0.0016
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0112 0.012
Mycobacterium leprae Probable lipase LipE 0.0118 0.051 0.1688
Echinococcus granulosus protein C ets 2 0.0011 0.0005 0.0005
Schistosoma mansoni ets-related 0.0011 0.0005 0.0005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0004 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0065 0.0259 0.101
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.0818 0.0818
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0183 0.0818 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0013 0.0142
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0121 0.0121
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0357 0.0981
Onchocerca volvulus 0.0032 0.0104 0.0941
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0013 0.0032
Onchocerca volvulus 0.0011 0.0006 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0085 0.0333
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0006 0.0006
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0013 0.0011 0.0011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0014 0.0035
Trichomonas vaginalis esterase, putative 0.0118 0.051 0.1254
Loa Loa (eye worm) inositol-1 0.0038 0.0131 0.0512
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0065 0.0259 0.0259
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0065 0.0259 0.0259
Schistosoma mansoni biogenic amine receptor 0.0011 0.0006 0.0006
Echinococcus granulosus fmrfamide receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0006 0.0006
Trypanosoma brucei glucosidase, putative 0.0036 0.0121 0.2283
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0104 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Trypanosoma brucei beta tubulin 0.0027 0.0081 0.1489
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Brugia malayi AKH receptor 0.0011 0.0006 0.0022
Toxoplasma gondii beta tubulin 0.0027 0.0081 0.0925
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Onchocerca volvulus 0.0118 0.051 0.4626
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0792 0.1948
Trypanosoma brucei beta tubulin 0.0027 0.0081 0.1489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0104 0.0104
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0006 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0403 0.1264
Brugia malayi putative neuropeptide receptor 0.0011 0.0006 0.0022
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis tumor protein p63 0.0355 0.1637 0.1637
Echinococcus multilocularis dnaJ subfamily B 0.125 0.5888 0.5888
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0065 0.0259 0.0259
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0126 0.049
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0018
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0183 0.0818 0.0818
Loa Loa (eye worm) fli-1 protein 0.0236 0.107 0.4171
Schistosoma mansoni hypothetical protein 0.0313 0.1437 0.1437
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0126 0.2377
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0131 0.2483
Schistosoma mansoni alpha glucosidase 0.0036 0.0121 0.0121
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0131 0.0131
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0006 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0104 0.0104
Echinococcus granulosus beta tubulin 0.0027 0.0081 0.0081
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0149 0.0362
Onchocerca volvulus 0.0118 0.051 0.4626
Echinococcus granulosus tubulin beta 4A class IVa 0.0027 0.0081 0.0081
Echinococcus granulosus allatostatin A receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0006 0.0006
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0013 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.051 0.1254
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.5367
Plasmodium falciparum glutathione reductase 0.0013 0.0013 0.0973
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0014 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0006 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.004 0.0093
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0013 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0508 0.1982
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0121 0.0121
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0131 0.0511
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.006 0.006
Echinococcus multilocularis importin subunit beta 1 0.0029 0.009 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.051 1
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0013 0.0011 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0006 0.0006
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.1167 0.4551
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni neuropeptide receptor 0.0011 0.0006 0.0006
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0126 0.0126
Mycobacterium tuberculosis Conserved protein 0.0118 0.051 0.1417
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.0013
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0005 0.0005
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0259 0.101
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0033 0.0109 0.0109
Onchocerca volvulus 0.0011 0.0006 0.0052
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0006 0.0006
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0084 0.0327
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.004 0.0083
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0013 0.0011 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi MH2 domain containing protein 0.0117 0.0508 0.1982
Onchocerca volvulus 0.0011 0.0006 0.0052
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0006 0.0006
Brugia malayi hypothetical protein 0.0016 0.0028 0.0108
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0131 0.0459
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0131 0.0131
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0013 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0131 0.0319
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0118 0.051 0.1417
Brugia malayi beta-lactamase family protein 0.0118 0.051 0.199
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0182 0.0182
Plasmodium vivax tubulin beta chain, putative 0.0027 0.0081 0.1394
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.0013
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Onchocerca volvulus 0.0011 0.0006 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.0118 0.051 0.1417
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0065 0.0259 0.0259
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0118 0.051 0.1417
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0397 0.0397
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0163 0.0163
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0006 0.0022
Schistosoma mansoni ets-related 0.0236 0.107 0.107
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Entamoeba histolytica tubulin family protein 0.0027 0.0081 0.0199
Entamoeba histolytica tubulin family protein 0.0027 0.0081 0.0199
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0562 0.262 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0013 0.0049
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0046 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0006 0.0006
Echinococcus granulosus neuropeptide receptor 0.0011 0.0006 0.0006
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0032 0.0104 0.0355
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0006 0.0022
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Brugia malayi Ets-domain containing protein 0.0078 0.032 0.1246
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0005 0.0018
Echinococcus multilocularis serotonin receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0011 0.0023
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0014 0.0131
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.006 0.006
Echinococcus granulosus nervana 2 0.0065 0.0259 0.0259
Mycobacterium leprae conserved hypothetical protein 0.0118 0.051 0.1688
Brugia malayi RNA, U transporter 1 0.0083 0.0347 0.1353
Echinococcus multilocularis nervana 2 0.0065 0.0259 0.0259
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0064 0.0153
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.004 0.0669
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Giardia lamblia Beta tubulin 0.0027 0.0081 0.0186
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0562 0.262 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0357 0.1085
Mycobacterium tuberculosis Probable hydrolase 0.0118 0.051 0.1417
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0006 0.0022
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.009 0.1041
Schistosoma mansoni inositol monophosphatase 0.0038 0.0131 0.0131
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0006 0.0006
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0011 0.0006 0.0006
Onchocerca volvulus 0.0052 0.0198 0.1794
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0129 0.0331
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0132 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0116 0.0502 0.6102
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.004 0.0076
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.004 0.0415
Leishmania major trypanothione reductase 0.0038 0.0129 0.152
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.004 0.004
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Brugia malayi neuropeptide F receptor 0.0011 0.0006 0.0022
Brugia malayi Ets-domain containing protein 0.0011 0.0005 0.0018
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0357 0.0981
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0013 0.0013

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 30 nM Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay ChEMBL. 20329799
EC50 (functional) = 3.68 uM Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay ChEMBL. 20329799
EC50 (functional) = 5.19 uM Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay ChEMBL. 20329799
EC50 (functional) > 5.88 uM Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assay ChEMBL. 20329799
Emax (functional) = 75 % Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay relative to melanocortin 2 ChEMBL. 20329799
Emax (functional) = 95 % Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay relative to melanocortin 2 ChEMBL. 20329799
Emax (functional) = 107 % Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay relative to alpha melanocyte-stimulating hormone ChEMBL. 20329799
Ki (binding) > 10 nM Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp method ChEMBL. 20329799
Ki (binding) = 48 nM Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation counting ChEMBL. 20329799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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