Detailed information for compound 1119028

Basic information

Technical information
  • TDR Targets ID: 1119028
  • Name: [2-[2-(4-fluorophenoxy)ethyl]piperidin-1-yl]- (2-phenylphenyl)methanone
  • MW: 403.489 | Formula: C26H26FNO2
  • H donors: 0 H acceptors: 1 LogP: 6.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)OCCC1CCCCN1C(=O)c1ccccc1c1ccccc1
  • InChi: 1S/C26H26FNO2/c27-21-13-15-23(16-14-21)30-19-17-22-10-6-7-18-28(22)26(29)25-12-5-4-11-24(25)20-8-2-1-3-9-20/h1-5,8-9,11-16,22H,6-7,10,17-19H2
  • InChiKey: PZTKKGBQVCJMCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[2-(4-fluorophenoxy)ethyl]-1-piperidyl]-(2-phenylphenyl)methanone
  • [2-[2-(4-fluorophenoxy)ethyl]-1-piperidinyl]-(2-phenylphenyl)methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hypocretin (orexin) receptor 2 Starlite/ChEMBL References
Homo sapiens hypocretin (orexin) receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis G protein coupled receptor 139 Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma mansoni neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus sex peptide receptor hypocretin (orexin) receptor 1 425 aa 350 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0161
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.01 0.0312
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.002 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0071 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0293 0.1111
Trypanosoma brucei polo-like protein kinase 0.0112 0.0293 0.103
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0035 0.0069
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0019 0.0016 0.0022
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0082 0.0199
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.021 0.0582 0.2271
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.0391 0.0915
Brugia malayi intermediate filament protein 0.0027 0.0042 0.0052
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0078 0.4712
Schistosoma mansoni inositol monophosphatase 0.0037 0.0072 0.0135
Brugia malayi beta-lactamase 0.004 0.0078 0.0102
Onchocerca volvulus 0.0243 0.0678 0.0672
Schistosoma mansoni intermediate filament proteins 0.0027 0.0042 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0148 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0863 0.2509 0.9278
Schistosoma mansoni hypothetical protein 0.004 0.0078 0.015
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0072 0.0206
Loa Loa (eye worm) phosphatidylinositol kinase 0.0019 0.0016 0.0064
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.01 0.0336
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0078 0.0936
Onchocerca volvulus 0.0027 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0463
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0407 0.0555
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0144 0.035
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0078 0.0109
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0629 0.1818 0.6707
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.1379 0.1913
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0629 0.1818 0.6707
Brugia malayi hypothetical protein 0.0146 0.0391 0.0534
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0629 0.1818 0.4391
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0591 0.2354
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.021 0.0582 0.2271
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.0391 0.095
Echinococcus granulosus GPCR family 2 0.0048 0.0102 0.0248
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0304 0.0857 0.3131
Schistosoma mansoni hypothetical protein 0.004 0.0078 0.015
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0082 0.0203 0.075
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0082 0.0203 0.0274
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0086
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0019 0.0016 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0407 0.162
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0166
Schistosoma mansoni hypothetical protein 0.004 0.0078 0.015
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0019 0.0016 0.0000059668
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.01 0.0242
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0088 0.0269
Onchocerca volvulus Serine\/threonine kinase homolog 0.0112 0.0293 0.0287
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0293 0.1111
Onchocerca volvulus 0.004 0.0078 0.0072
Brugia malayi hypothetical protein 0.002 0.002 0.0021
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.01 0.0336
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0148 0.0322
Leishmania major hypothetical protein, conserved 0.0026 0.0039 0.0084
Loa Loa (eye worm) hypothetical protein 0.0128 0.0338 0.1348
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0629 0.1818 0.7229
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0078 0.0249
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0121 0.0482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0035 0.031
Echinococcus multilocularis neuropeptide receptor 0.0132 0.0352 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0015
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0678 0.2654
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0064
Entamoeba histolytica protein kinase domain containing protein 0.0863 0.2509 1
Giardia lamblia Kinase, CMGC GSK 0.0863 0.2509 0.9278
Loa Loa (eye worm) hypothetical protein 0.0462 0.1325 0.5281
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0016 0.0039
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2454 0.7208 1
Plasmodium vivax SET domain protein, putative 0.0031 0.0051 0.0132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0035 0.2988
Schistosoma mansoni inositol monophosphatase 0.0037 0.0072 0.0135
Brugia malayi Telomerase reverse transcriptase 0.2471 0.7258 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0192 0.0527 0.2102
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.021 0.0582 0.2271
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.01 0.0312
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0148 0.0491
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0016
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0203 0.0696
Echinococcus multilocularis nibrin 0.002 0.002 0.0027
Brugia malayi beta-lactamase family protein 0.004 0.0078 0.0102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0138
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0019 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0096 0.0243 0.0969
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0082 0.0203 0.0696
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0078 0.0231
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0078 0.0936
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0078 0.0936
Schistosoma mansoni topbp1 0.002 0.002 0.0009
Echinococcus multilocularis 0.0019 0.0016 0.0022
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.002 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0293 0.1111
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0243 0.0329
Mycobacterium ulcerans beta-lactamase 0.004 0.0078 0.4712
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0266 0.036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0016
Brugia malayi PHD-finger family protein 0.0031 0.0052 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.0863 0.2509 1
Schistosoma mansoni kinase 0.0061 0.0142 0.0306
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0243 0.059
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0243 0.0337
Brugia malayi serine/threonine-protein kinase plk-2 0.0112 0.0293 0.0398
Brugia malayi topoisomerase 0.002 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0064
Giardia lamblia PHD finger protein 15 0.0031 0.0052 0.0132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0102 0.0248
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0019 0.0016 0.0039
Brugia malayi intracellular kinase 0.0863 0.2509 0.3453
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0072 0.0223
Echinococcus multilocularis protein dispatched 1 0.0047 0.0099 0.0138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0035 0.0075
Loa Loa (eye worm) hypothetical protein 0.0462 0.1325 0.5281
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0079
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.021 0.0582 0.138
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0016 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0312
Trichomonas vaginalis CMGC family protein kinase 0.0863 0.2509 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0102 0.0248
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.021 0.0582 0.2271
Loa Loa (eye worm) hypothetical protein 0.0151 0.0407 0.162
Plasmodium falciparum telomerase reverse transcriptase 0.0929 0.2703 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0082 0.0203 0.075
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0078 0.4712
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.1439 0.5735
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0148 0.0589
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.002 0.0286
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.021 0.0582 0.2107
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.0209
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0072 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0039 0.0084
Schistosoma mansoni hypothetical protein 0.004 0.0078 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0293 0.1111
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0016
Echinococcus granulosus neuropeptide receptor 0.0132 0.0352 0.0853
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0138
Toxoplasma gondii ABC1 family protein 0.004 0.0078 0.0231
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0072 0.0099
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0148 0.1938
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0035 0.1409
Schistosoma mansoni neuropeptide receptor 0.0132 0.0352 0.0818
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0205
Schistosoma mansoni patched 1 0.0041 0.0082 0.0161
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.0675 0.269
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0087 0.0211
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0102 0.0142
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0016 0.0064
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0293 0.1111
Loa Loa (eye worm) hypothetical protein 0.0407 0.1164 0.4639
Giardia lamblia Kinase, CMGC GSK 0.0863 0.2509 0.9278
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0082 0.0203 0.0493
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0203 0.0696
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0078 0.0936
Trichomonas vaginalis esterase, putative 0.004 0.0078 0.0249
Onchocerca volvulus Huntingtin homolog 0.0128 0.0338 0.0333
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0016 0.0000059668
Schistosoma mansoni hypothetical protein 0.0146 0.0391 0.0915
Echinococcus multilocularis serine protein kinase ATM 0.0019 0.0016 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0102 0.0407
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0019 0.0016 0.0022
Loa Loa (eye worm) beta-lactamase 0.004 0.0078 0.0312
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0147 0.0395 0.1412
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0327
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0082 0.0203 0.0696
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0407 0.1164 0.1615
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0051 0.0071
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.1439 0.5707
Chlamydia trachomatis DNA ligase 0.002 0.002 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0192 0.0527 0.1903
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.002 0.0014
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0078 0.0936
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0079
Plasmodium vivax telomerase reverse transcriptase, putative 0.0929 0.2703 1
Onchocerca volvulus 0.004 0.0078 0.0072
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0629 0.1818 0.2523
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0863 0.2509 0.3481
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0082 0.0114
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0148 0.0205
Toxoplasma gondii RNA-directed DNA polymerase 0.0929 0.2703 1
Echinococcus multilocularis expressed conserved protein 0.009 0.0226 0.0313
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0432 0.1237 0.4896
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0293 0.103
Trypanosoma brucei protein kinase, putative 0.0863 0.2509 0.9278
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0312
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0257 0.0625
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0407 0.1164 0.2825
Onchocerca volvulus 0.0025 0.0035 0.0029
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0071 0.0171
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0331 0.1321
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0052 0.0132
Echinococcus multilocularis protein patched 0.0041 0.0082 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0035 0.1409
Echinococcus multilocularis Zinc finger, PHD finger 0.0082 0.0203 0.0282
Mycobacterium leprae conserved hypothetical protein 0.004 0.0078 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0051 0.0086
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0144 0.1884
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0148 0.0322
Trypanosoma brucei telomerase reverse transcriptase 0.0929 0.2703 1
Brugia malayi hypothetical protein 0.0017 0.0011 0.0009
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0088 0.0289
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0432 0.1237 0.4896
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0082 0.0199
Brugia malayi Pre-SET motif family protein 0.0031 0.0051 0.0065
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0052 0.0086
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0072 0.0206
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0078 0.0231
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0082 0.0203 0.0455
Leishmania major telomerase reverse transcriptase, putative 0.0929 0.2703 1
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0293 0.1111
Entamoeba histolytica hypothetical protein 0.0146 0.0391 0.1506
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.002 0.0014
Loa Loa (eye worm) inositol-1 0.0037 0.0072 0.0285
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0016 0.0000059668
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0203 0.0696
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0035 0.1409
Echinococcus granulosus neuropeptide receptor A26 0.048 0.1379 0.3347
Mycobacterium leprae Probable lipase LipE 0.004 0.0078 1
Brugia malayi Pre-SET motif family protein 0.0213 0.0591 0.0808
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0035 0.031
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.021 0.0582 0.2107
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0082 0.0265
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0144 0.9717
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.002 0.0014
Plasmodium vivax glycogen synthase kinase 3, putative 0.0863 0.2509 0.9278
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0102 0.0142
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0279 0.0785 0.3083
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0072 0.0206
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0039 0.0084
Brugia malayi jmjC domain containing protein 0.01 0.0257 0.0349
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0082 0.0327
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0078 0.0249
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.021 0.0582 0.0797
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0364 0.0505
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0035 0.0075
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0016 0.0043
Giardia lamblia Replication factor C, subunit 1 0.002 0.002 0.0014
Plasmodium falciparum phd finger protein, putative 0.0031 0.0052 0.0132
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0078 0.019
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0042 0.0052
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0929 0.2703 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0064
Onchocerca volvulus 0.0031 0.0051 0.0046
Onchocerca volvulus 0.0462 0.1325 0.132
Entamoeba histolytica hypothetical protein 0.0146 0.0391 0.1506
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0051 0.0086
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0051 0.0071
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.002 0.0015
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.0209
Onchocerca volvulus 0.002 0.002 0.0014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0243 0.0911
Onchocerca volvulus 0.0863 0.2509 0.2505
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0312
Schistosoma mansoni topbp1 0.002 0.002 0.0009
Echinococcus granulosus intermediate filament protein 0.0027 0.0042 0.0101
Leishmania major hypothetical protein, conserved 0.004 0.0078 0.0231
Echinococcus multilocularis replication factor c subunit 1 0.002 0.002 0.0027
Mycobacterium ulcerans hypothetical protein 0.004 0.0078 0.4712
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0035 0.2988
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0052 0.0132
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0863 0.2509 1
Echinococcus multilocularis protein kinase shaggy 0.0863 0.2509 0.3481
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0112 0.0293 0.103
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0019 0.0016 0.0039
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0019 0.0016 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0039 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0071 0.0133
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0102 0.0135
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0048 0.0117
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0035 0.0075
Entamoeba histolytica hypothetical protein 0.002 0.002 0.0015
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0071 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0016 0.0000059668
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0039 0.0084
Entamoeba histolytica hypothetical protein 0.0146 0.0391 0.1506
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0082 0.0203 0.0809
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0064
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0112 0.0293 0.0711
Echinococcus multilocularis GPCR, family 2 0.0048 0.0102 0.0142
Echinococcus granulosus serine protein kinase ATM 0.0019 0.0016 0.0039
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0144 0.02
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0138 0.0488
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0016 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0039 0.0084
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0082 0.0203 0.0493
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0312
Echinococcus granulosus lamin 0.0027 0.0042 0.0101
Mycobacterium ulcerans hypothetical protein 0.0025 0.0035 0.1409
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0863 0.2509 0.9278
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0144 0.0312
Echinococcus granulosus neuropeptide s receptor 0.048 0.1379 0.3347
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.01 0.0312
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0072 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0293 0.0675
Schistosoma mansoni lamin 0.0027 0.0042 0.0063
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0019 0.0016 0.0022
Echinococcus granulosus nibrin 0.002 0.002 0.0048
Brugia malayi hypothetical protein 0.0462 0.1325 0.1821
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0072 0.0174
Schistosoma mansoni jumonji domain containing protein 0.008 0.0196 0.044
Brugia malayi CHE-14 protein 0.0041 0.0082 0.0107
Brugia malayi follicle stimulating hormone receptor 0.0242 0.0675 0.0925
Schistosoma mansoni fkbp-rapamycin associated protein 0.0019 0.0016 0.0000000092168
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0863 0.2509 0.6089
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0015
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0419 0.1018
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0078 0.0231
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0052 0.0071
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0102 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0079
Echinococcus granulosus protein kinase shaggy 0.0863 0.2509 0.6089
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0078 0.0936
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0144 0.0477
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0247 0.0564
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0087 0.0121
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0293 0.103
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.0209
Onchocerca volvulus 0.0019 0.0016 0.001
Schistosoma mansoni lamin 0.0027 0.0042 0.0063
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0863 0.2509 0.6074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0016
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.006 0.7059
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0035 0.0069
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0364 0.0884
Entamoeba histolytica protein kinase, putative 0.0863 0.2509 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0072 0.0223
Brugia malayi MH2 domain containing protein 0.0125 0.0331 0.0451
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0148 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0629 0.1818 0.2501
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.0391 0.0543
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0078 0.0312
Plasmodium falciparum glycogen synthase kinase 3 0.0863 0.2509 0.9278
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0629 0.1818 0.7229
Schistosoma mansoni microtubule-associated protein tau 0.1409 0.412 1
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.002 0.0605
Echinococcus granulosus peregrin 0.0035 0.0063 0.0153
Brugia malayi hypothetical protein 0.002 0.002 0.0021
Mycobacterium ulcerans lipase LipD 0.004 0.0078 0.4712
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0112 0.0293 0.1167
Echinococcus granulosus microtubule associated protein 2 0.1409 0.412 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.002 0.0015
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0019 0.0016 0.0000059668
Brugia malayi Bromodomain containing protein 0.0035 0.0063 0.0081
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0052 0.0205
Giardia lamblia Kinase, PLK 0.0112 0.0293 0.103
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0082 0.0203 0.0282
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0433 0.06
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0019 0.0016 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0148 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0016 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0407 0.1164 0.1599
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0144 0.0193
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0064
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.061 0.1763 0.7008
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0312
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0407 0.0555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0051 0.0086
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0072 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0064
Leishmania major phosphatidylinositol 3-kinase, putative 0.0082 0.0203 0.0696
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0078 0.0152
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0042 0.0166
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0629 0.1818 0.7229
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.0203 0.075
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0015
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0203 0.0696
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0019 0.0016 0.0000059668
Onchocerca volvulus 0.0019 0.0016 0.001
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0433 0.1015
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0078 0.0936
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0072 0.0206
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0079
Brugia malayi hypothetical protein 0.0128 0.0338 0.046
Plasmodium vivax hypothetical protein 0.0019 0.0016 0.0000059668
Loa Loa (eye worm) runx1 0.0058 0.0132 0.0527
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0144 0.9717
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0016 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0078 0.0249
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.002 0.0015
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0148 0.0491
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0064
Treponema pallidum DNA ligase (lig) 0.002 0.002 0.5
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0035 0.1409
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0082 0.0203 0.0455
Entamoeba histolytica serine/threonine protein kinase, putative 0.0112 0.0293 0.1111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0051 0.0086
Plasmodium vivax hypothetical protein, conserved 0.004 0.0078 0.0231
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0203 0.0696
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0082 0.0203 0.075
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0088 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0293 0.1111
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0016 0.0064
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.021 0.0582 0.2271
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0331 0.1321
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0929 0.2703 1
Onchocerca volvulus 0.0027 0.0042 0.0036
Schistosoma mansoni hypothetical protein 0.0103 0.0266 0.0608
Echinococcus multilocularis peregrin 0.0035 0.0063 0.0087
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0016 0.0043
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0148 0.0359
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0035 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0016 0.0064
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0079
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0407
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0203 0.0696
Echinococcus granulosus lamin dm0 0.0027 0.0042 0.0101
Onchocerca volvulus 0.004 0.0078 0.0072
Schistosoma mansoni DNA ligase IV 0.002 0.002 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0035 0.0069
Brugia malayi Inositol-1 0.0037 0.0072 0.0093
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0042 0.0166
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0154
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0863 0.2509 0.9278
Onchocerca volvulus Alhambra homolog 0.0031 0.0052 0.0046
Echinococcus multilocularis neuropeptide s receptor 0.048 0.1379 0.1913
Onchocerca volvulus Huntingtin homolog 0.0128 0.0338 0.0333
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0629 0.1818 0.7229
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0312
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0863 0.2509 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0078 0.0936
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0112 0.0293 0.0406
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.002 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0015
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0039 0.0084
Loa Loa (eye worm) acetyltransferase 0.016 0.0433 0.1725
Giardia lamblia Telomerase catalytic subunit 0.0929 0.2703 1
Toxoplasma gondii ATPase, AAA family protein 0.002 0.002 0.0014
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.0209
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.071 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0039 0.0084
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0051 0.0125
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0433 0.0591
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.002 0.0014
Echinococcus multilocularis lamin 0.0027 0.0042 0.0058
Echinococcus granulosus expressed conserved protein 0.009 0.0226 0.0548
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0035 0.1409
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0257 0.0357
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0035 0.1409
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0035 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0035 0.0042
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.002 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0863 0.2509 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0078 0.0936
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.006 0.0673
Entamoeba histolytica hypothetical protein 0.0146 0.0391 0.1506
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0052 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0051 0.0131
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.002 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0015
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0082 0.0203 0.075
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0052 0.0132
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.002 0.0021
Echinococcus multilocularis lamin dm0 0.0027 0.0042 0.0058
Echinococcus multilocularis musashi 0.0027 0.0042 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.1409 0.412 0.5716
Echinococcus multilocularis Protein lozenge 0.0058 0.0132 0.0183
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0016 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0078 0.0152
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0016
Mycobacterium tuberculosis Conserved protein 0.004 0.0078 0.0936
Brugia malayi jmjC domain containing protein 0.0037 0.0071 0.0091
Entamoeba histolytica hypothetical protein 0.0501 0.1439 0.5707
Echinococcus granulosus replication factor c subunit 1 0.002 0.002 0.0048
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0071 0.0281
Brugia malayi beta-lactamase family protein 0.004 0.0078 0.0102
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0629 0.1818 0.4413
Loa Loa (eye worm) hypothetical protein 0.0103 0.0266 0.1059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0205
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0035 0.1409
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0072 0.4203
Echinococcus multilocularis G protein coupled receptor 139 0.0132 0.0352 0.0488
Loa Loa (eye worm) hypothetical protein 0.0222 0.0615 0.2453
Brugia malayi DKFZp564C0469 protein 0.002 0.002 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0128 0.0338 0.1348
Schistosoma mansoni lozenge 0.0058 0.0132 0.0283
Brugia malayi hypothetical protein 0.0026 0.0039 0.0047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0078 0.0102
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0436
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.002 0.0014
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0072 0.0223
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0078 0.0249
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0078 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0138 0.0488

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 7.7 Antagonist activity at recombinant human OX2R expressed in CHO cells by FLIPR calcium based functional assay ChEMBL. 21831639
Ki (functional) = 8.3 Antagonist activity at recombinant human OX1R expressed in CHO cells by FLIPR calcium based functional assay ChEMBL. 21831639

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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