Detailed information for compound 1120862

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 361.248 | Formula: C11H16N5O7P
  • H donors: 5 H acceptors: 8 LogP: -3.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]([C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N)OP(=O)(O)O
  • InChi: 1S/C11H16N5O7P/c1-4(23-24(19,20)21)8-6(17)7(18)11(22-8)16-3-15-5-9(12)13-2-14-10(5)16/h2-4,6-8,11,17-18H,1H3,(H2,12,13,14)(H2,19,20,21)/t4-,6+,7-,8-,11?/m1/s1
  • InChiKey: DYBVOLZBAYFUSE-OWBHPXMMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0021 0.0019
Brugia malayi intermediate filament protein 0.0027 0.006 0.0125
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.017 0.0394
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0325 0.0783
Leishmania major solanesyl-diphosphate synthase, putative 0.0257 0.1003 0.2415
Echinococcus multilocularis lamin 0.0027 0.006 0.0058
Echinococcus granulosus dna polymerase eta 0.0015 0.0008 0.0015
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0257 0.1003 0.1001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0008 0.0006
Trypanosoma cruzi polyprenyl synthase, putative 0.0257 0.1003 0.2415
Echinococcus multilocularis dna polymerase eta 0.0015 0.0008 0.0006
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0143 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.102 0.4126 1
Schistosoma mansoni lamin 0.0027 0.006 0.0125
Trypanosoma brucei farnesyl pyrophosphate synthase 0.102 0.4126 1
Echinococcus multilocularis musashi 0.0027 0.006 0.0058
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0035 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0021 0.0031
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0257 0.1003 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Brugia malayi Flap endonuclease-1 0.0026 0.0053 0.0109
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0118 0.0034
Loa Loa (eye worm) glutaminase 2 0.0275 0.1074 0.2603
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0104 0.0126
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0257 0.1003 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0093 0.0206
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0053 0.0109
Trypanosoma cruzi ISWI complex protein 0.0016 0.0013 0.0013
Trypanosoma cruzi polyprenyl synthase, putative 0.0257 0.1003 0.2415
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.0013
Echinococcus granulosus lamin 0.0027 0.006 0.0139
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0008 0.0015
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0257 0.1003 0.2426
Schistosoma mansoni zinc finger protein 0.0016 0.0013 0.0013
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.0313
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0044 0.0102
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.002
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0143 0.0328
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0257 0.1003 0.2415
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0602
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0118 0.0034
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.102 0.4126 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0021 0.0019
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.005
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0143 0.0343
Loa Loa (eye worm) hypothetical protein 0.0042 0.0121 0.0293
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0143 0.0347
Trypanosoma brucei unspecified product 0.0035 0.009 0.02
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.102 0.4126 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0118 0.0266
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.102 0.4126 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0044 0.0087
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.102 0.4126 1
Echinococcus multilocularis zinc finger protein 0.002 0.0031 0.0029
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0257 0.1003 0.2331
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0257 0.1003 0.2331
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0257 0.1003 0.2234
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.017 0.0394
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.017 0.0168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0325 0.0323
Schistosoma mansoni zinc finger protein 0.002 0.0031 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0144
Schistosoma mansoni hypothetical protein 0.0289 0.1133 0.2732
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0044 0.0042
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0257 0.1003 0.2415
Loa Loa (eye worm) glutaminase 0.0275 0.1074 0.2603
Loa Loa (eye worm) hypothetical protein 0.0054 0.017 0.0413
Entamoeba histolytica hypothetical protein 0.0035 0.0093 0.0853
Echinococcus granulosus geminin 0.0527 0.2105 0.51
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0053 0.0452
Schistosoma mansoni trans-prenyltransferase 0.0257 0.1003 0.2415
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0021 0.0031
Leishmania major DNA polymerase kappa, putative 0.0021 0.0035 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0017 0.0021
Brugia malayi PHD-finger family protein 0.0026 0.0054 0.0112
Mycobacterium ulcerans glutaminase 0.0275 0.1074 0.2411
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.102 0.4126 1
Leishmania major farnesyl pyrophosphate synthase 0.102 0.4126 1
Schistosoma mansoni glutaminase 0.0275 0.1074 0.2588
Leishmania major polyprenyl synthase, putative 0.0257 0.1003 0.2415
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0257 0.1003 0.2426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0325 0.0769
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0104 0.0233
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0257 0.1003 0.1001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0201 0.0199
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.0716 0.1732
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0036 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0166
Schistosoma mansoni glutathione synthetase 0.0257 0.1003 0.2415
Loa Loa (eye worm) polyprenyl synthetase 0.0257 0.1003 0.243
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0118 0.0159
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0118 0.0159
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0185
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0325 0.0323
Treponema pallidum octaprenyl-diphosphate synthase 0.0257 0.1003 0.5
Onchocerca volvulus 0.0048 0.0143 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0008 0.0019
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0257 0.1003 0.2426
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0104 0.0248
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0101 0.0239
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.017 0.0168
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0104 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0035 0.0066
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0008 0.002
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0053 0.0109
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0257 0.1003 0.243
Entamoeba histolytica hypothetical protein 0.0035 0.0093 0.0853
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.102 0.4126 0.4125
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0257 0.1003 0.2415
Echinococcus granulosus flap endonuclease 1 0.0026 0.0053 0.0124
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.102 0.4126 1
Trypanosoma brucei ISWI complex protein 0.0016 0.0013 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0027 0.006 0.0144
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.006 0.0125
Schistosoma mansoni flap endonuclease-1 0.0023 0.0043 0.0085
Echinococcus granulosus lamin dm0 0.0027 0.006 0.0139
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0201 0.0484
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0257 0.1003 0.2415
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0257 0.1003 1
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0143 0.0141
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0053 0.0043
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0257 0.1003 0.2234
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Echinococcus granulosus dna polymerase kappa 0.0041 0.0118 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0017 0.0021
Brugia malayi Bromodomain containing protein 0.0078 0.0266 0.0627
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0104 0.0102
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.017 0.0408
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0257 0.1003 1
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0257 0.1003 0.2415
Schistosoma mansoni inositol monophosphatase 0.0038 0.0104 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Loa Loa (eye worm) inositol-1 0.0038 0.0104 0.0252
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0257 0.1003 0.2415
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0257 0.1003 0.2415
Brugia malayi polk-prov protein 0.0031 0.0077 0.0167
Schistosoma mansoni hypothetical protein 0.0534 0.2138 0.5171
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0325 0.0769
Schistosoma mansoni bromodomain containing protein 0.0065 0.0217 0.0507
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0257 0.1003 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0325 0.077
Brugia malayi Bromodomain containing protein 0.004 0.0111 0.025
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.102 0.4126 1
Echinococcus granulosus intermediate filament protein 0.0027 0.006 0.0139
Schistosoma mansoni hypothetical protein 0.0035 0.0093 0.0206
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0534 0.2138 0.5178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0325 0.0769
Trypanosoma cruzi ISWI complex protein 0.0016 0.0013 0.0013
Schistosoma mansoni farnesyl pyrophosphate synthase 0.102 0.4126 1
Schistosoma mansoni hypothetical protein 0.0534 0.2138 0.5171
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0118 0.0266
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0104 0.0126
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0104 0.0126
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0104 0.0233
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0053 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0257 0.1003 0.2415
Brugia malayi indoleamine 2,3-dioxygenase 0.0534 0.2138 0.5171
Schistosoma mansoni hypothetical protein 0.0527 0.2105 0.5093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0093 0.022
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0104 0.0233
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0021 0.0045
Loa Loa (eye worm) polyprenyl synthetase 0.102 0.4126 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0053 0.0109
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0257 0.1003 0.2331
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.102 0.4126 1
Loa Loa (eye worm) MBCTL1 0.0054 0.017 0.0413
Schistosoma mansoni inositol monophosphatase 0.0038 0.0104 0.0233
Brugia malayi Inositol-1 0.0038 0.0104 0.0234
Loa Loa (eye worm) hypothetical protein 0.0048 0.0143 0.0347
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0257 0.1003 0.2415
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0257 0.1003 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0021 0.0045
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0118 0.0116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0093 0.0091
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0534 0.2138 0.518
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0166
Brugia malayi Polyprenyl synthetase family protein 0.102 0.4126 1
Brugia malayi hypothetical protein 0.0035 0.0093 0.0206
Brugia malayi Polyprenyl synthetase family protein 0.0257 0.1003 0.2415
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0143 0.0328
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0021 0.0031
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0053 0.0051
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0088 0.0194
Trichomonas vaginalis glutaminase, putative 0.0275 0.1074 0.2507
Schistosoma mansoni hypothetical protein 0.0527 0.2105 0.5093
Entamoeba histolytica hypothetical protein 0.0035 0.0093 0.0853
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0325 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0017 0.0021
Schistosoma mansoni lamin 0.0027 0.006 0.0125
Echinococcus granulosus farnesyl pyrophosphate synthase 0.102 0.4126 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0143 0.0141
Brugia malayi glutaminase DH11.1 0.0275 0.1074 0.2589
Brugia malayi mbt repeat family protein 0.0048 0.0143 0.0329
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0143 0.0343
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0257 0.1003 1
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0534 0.2138 0.2136
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0021 0.0031
Echinococcus multilocularis lamin dm0 0.0027 0.006 0.0058
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0101 0.0099
Schistosoma mansoni intermediate filament proteins 0.0027 0.006 0.0125
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0104 0.0233
Brugia malayi mbt repeat family protein 0.0048 0.0143 0.0329
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0104 0.0966
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0023 0.0056
Echinococcus granulosus zinc finger protein 0.002 0.0031 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.009 0.02
Echinococcus multilocularis geminin 0.0527 0.2105 0.2104
Giardia lamblia Farnesyl diphosphate synthase 0.102 0.4126 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0143 0.0328
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0325 0.0783
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.006 0.0144
Schistosoma mansoni hypothetical protein 0.0021 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0139
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0269
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0118 0.0266
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.102 0.4126 1
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0257 0.1003 1
Entamoeba histolytica hypothetical protein 0.0035 0.0093 0.0853
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.017 0.0408
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.102 0.4126 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.0716 0.0715

Activities

Activity type Activity value Assay description Source Reference
Inhibition index (functional) = 0.008 Inhibition index was the ratio between KM of AMP and Ki of AK III ChEMBL. 6286970
Inhibition index (functional) = 0.0082 Inhibition index was the ratio between KM of AMP and Ki of AK II ChEMBL. 6286970
Ki (binding) = 9.8 mM Competitive inhibitory constant with Rat adenylate kinase II isozyme ChEMBL. 6286970
Ki (binding) = 9.8 mM Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, non competitive inhibition ChEMBL. 6292418
Ki (binding) = 10 mM Competitive inhibitory constant with Rat adenylate kinase III ChEMBL. 6286970
Ki (binding) = 16 mM Non-competitive inhibitory constant of compound with Rat adenylate kinase M isozyme ChEMBL. 6286970
Ki (binding) = 16 mM Inhibitory activity against rat Adenylate kinase M isoenzyme was determined in the presence of ATP, non competitive inhibition ChEMBL. 6292418
Relative Vmax (binding) = 0 Relative Vmax value to Adenylate kinase M isoenzyme (adenylate kinase 1, AK1) ChEMBL. 6286970
Relative Vmax (binding) > 0 Relative Vmax value to rat adenylate kinase II. ChEMBL. 6286970
Relative Vmax (binding) > 0 Relative Vmax value to rat adenylate kinase III. ChEMBL. 6286970

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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